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VGRSEELAAVTDVLADISTGGAALVIDGDPGIGKSTLLAAASDWAVANGYARLGCSGLQSQMEIGYAGLH ELLHPLLAQVDALPPRQRAALMTAFGLEDGPPPDRMLIGLSVLGLLEEAAGNRRLFLVIDDAQWLDPSSV DVLNFVARRLSNAPLMMLCSTRTTLDGFSVQFDGLPRLTMGPLEPADAAELLALTLRDPERSDRVDEVAR QRILEQANGNPMAVIELTIALIESGDGAPIFAGEPLPTTRRVERAFLTQLGPLSDESRLLLLLIATGNGL LSEIDWAADHLGFSLTEHLGSLEESGLITVAGGRIQIRHPLIRSTVYGAAALASRAAVHRALAAAATDPA RAAWHRAEAAFGPNEEVAADLERVADRARVRGAGAEAAAALRRAAALTDDPQERLRRMTVAAEVARSSGL IAESVRILREAEPLIREHESETPLAITRFVLNATAATPGQSADELLALSRKIADDDPGRRQLLWAAAIEC RMHGLPEHSRRDVVAEIGRLDDDPHDPLTAIALALADDTGKGAGLRARLPQLVDTVGDSPLLMLSLAFAA EAVTDRAGALKCWTHVQNQARNCGSLAEECEGLRGAANILLTEGHVEAAAMSAQTALHMAESMNIAMTAG SAAAILARALVWQGQGERARHVLDRARHHLSPAPTILWNDDVHWAAGLAALCEADHTQALGHLTQMTLHR TSRRWAIADLAEAAAGAEKADIARPLLAEAEEQAERLGIDSFLVHRAHALLADSVAESEDRFRAALGAAE RTGAELESARTHLLYGVWLRRRRRIVDARVHLSAALTAFDRAGAVPFAERAAAELRAAGVTSAPRPGTHS GADAGALTPQELQIAQMAAAGMTNREIADRIYLSHRTVAAHLYKVFPKLGITRRNQLHAALGAPTGIA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6828 | - | - | 100% (909) | transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_0321 | - | e-102 | 35.16% (950) | transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_3290 | - | 1e-99 | 33.91% (929) | regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2515c | - | 1e-16 | 23.04% (959) | LuxR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4504 | - | 9e-65 | 28.86% (946) | regulatory protein, LuxR |
| M. tuberculosis H37Rv | Rv2488c | - | 1e-16 | 23.04% (959) | LuxR family transcriptional regulator |
| M. leprae Br4923 | MLBr_02341 | - | 2e-12 | 24.33% (485) | putative regulatory protein |
| M. abscessus ATCC 19977 | MAB_3361 | - | 3e-95 | 32.72% (920) | LuxR family transcriptional regulator |
| M. marinum M | MMAR_0085 | - | 2e-87 | 30.77% (949) | transcriptional regulatory protein |
| M. avium 104 | MAV_2362 | - | 3e-19 | 24.26% (977) | TPR repeat-containing protein |
| M. thermoresistible (build 8) | TH_3225 | - | 2e-93 | 32.95% (950) | PUTATIVE regulatory protein, LuxR |
| M. ulcerans Agy99 | MUL_2555 | - | 2e-31 | 28.98% (559) | hypothetical protein MUL_2555 |
| M. vanbaalenii PYR-1 | Mvan_5449 | - | 1e-105 | 34.01% (935) | regulatory protein, LuxR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2515c|M.bovis_AF2122/97 ---MDRRPRDFEQSRRRCRCNALRAGSMLASMSKIHPGVDVVPVDWSADG
Rv2488c|M.tuberculosis_H37Rv ---MDRRPRDFEQSRRRCRCNALRAGSMLASMSKIHPGVDVVPVDWSADG
MAB_3361|M.abscessus_ATCC_1997 -------------------------------------------------M
TH_3225|M.thermoresistible__bu --------MSSRDGDVVLHGRAAEIATLRDVMSTARAGSS------RVLV
MMAR_0085|M.marinum_M ------------MPTVTLVGRHREQQQLQQLLDAARRGES------GVLV
Mvan_5449|M.vanbaalenii_PYR-1 MTSSAQPIRPSQESQVELVGRRAERRALDGVLSAVSAGRSGVLVLSGVLV
MSMEG_6828|M.smegmatis_MC2_155 -----------------MVGRSEELAAVTDVLADISTGGA-------ALV
Mflv_4504|M.gilvum_PYR-GCK --MRAALPAAMMNAMSDASPQAADDPQVAGFLCTATSAPTG-------LI
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
MAV_2362|M.avium_104 ---------------------MGREAELRRSLAALSNAEFHG------VA
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
Mb2515c|M.bovis_AF2122/97 VSELVPTGTVTLLLADIEGATHLPGSQLDTTAIAKLDRTLTELVREHRGV
Rv2488c|M.tuberculosis_H37Rv VSELVPTGTVTLLLADIEGATHLPGSQLDTTAIAKLDRTLTELVREHRGV
MAB_3361|M.abscessus_ATCC_1997 LRGQAGVGKTALLRYVLGKASG--------QLIAQASGIQSEMELAFAGL
TH_3225|M.thermoresistible__bu LHGEAGVGKTALLGQLLGDAAG--------MRCVQVAGVESDMELAYAGL
MMAR_0085|M.marinum_M LRGDAGIGKTTLLTDLVDNAPD--------LRVLRVRGAEMEMELTYSGV
Mvan_5449|M.vanbaalenii_PYR-1 LSGEAGIGKTALLDEVAGQIAE--------GLLVRVAGVESETEFAYAAL
MSMEG_6828|M.smegmatis_MC2_155 IDGDPGIGKSTLLAAASDWAVAN------GYARLGCSGLQSQMEIGYAGL
Mflv_4504|M.gilvum_PYR-GCK IEGDAGIGKTTLWLSLLQTARMRG------FQVLTARVGQAESVMAFAAL
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
MAV_2362|M.avium_104 LVGDAGVGKSTLARMLAKTVESAG------RTVRFALGTQTGSAVPLGAF
MLBr_02341|M.leprae_Br4923 ---------------------------------MTTALVCVACGAELRSI
Mb2515c|M.bovis_AF2122/97 CPVEQGE-GDSFLVAFARASDAVACALGLQRAPL-APIRLRIGMHTGEVS
Rv2488c|M.tuberculosis_H37Rv CPVEQGE-GDSFLVAFARASDAVACALGLQRAPL-APIRLRIGMHTGEVS
MAB_3361|M.abscessus_ATCC_1997 QQFCAPL-TKYSGAIPDPQREALTIAFGTRSGP--PPDRFLIGLAVLSLL
TH_3225|M.thermoresistible__bu HQLCAPL-LDRLDDLPSPQRDVLNVAFGRGAGP--APGRFLVGLAVLNLL
MMAR_0085|M.marinum_M QQLCGPL-MSLIGQLPEPQLDALEIALGRKRGR--APDRLLLGLAVLTLV
Mvan_5449|M.vanbaalenii_PYR-1 HQLCIPL-FERIEQIPGPQRAALLTAFGQRRSP--TPDPFLVGLAVLSLV
MSMEG_6828|M.smegmatis_MC2_155 HELLHPL-LAQVDALPPRQRAALMTAFGLEDGP--PPDRMLIGLSVLGLL
Mflv_4504|M.gilvum_PYR-GCK ADLLGAVSDEHFAALPPLQRLALDRVLLRAGADGPATDQRVVAAGFVSLL
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
MAV_2362|M.avium_104 SHAVSLMAVNEPAVMLAAAHNTLSQDKN----------------------
MLBr_02341|M.leprae_Br4923 AKFCDECGSPVVEAETPAEYKQVT--------------------------
Mb2515c|M.bovis_AF2122/97 SPDEGNCVGPTIDRTARLRELAHGGQTVLSGTTSDLVADLLPKDAWLNDL
Rv2488c|M.tuberculosis_H37Rv SPDEGNCVGPTIDRTARLRELAHGGQTVLSGTTSDLVADLLPKDAWLNDL
MAB_3361|M.abscessus_ATCC_1997 AAAAEHQP----------------------------VLCVIDDAQWLDRV
TH_3225|M.thermoresistible__bu AAAGADQP----------------------------LLCVIDDAQWLDRV
MMAR_0085|M.marinum_M GEASRASP----------------------------ILCVVDDAQWVDSA
Mvan_5449|M.vanbaalenii_PYR-1 SEFVHQCP----------------------------VFLIIDDQQWLDRA
MSMEG_6828|M.smegmatis_MC2_155 EEAAGNRR----------------------------LFLVIDDAQWLDPS
Mflv_4504|M.gilvum_PYR-GCK HILAADAP----------------------------VLIAIDDVQWLDAS
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
MAV_2362|M.avium_104 ------------------------------------LVVVVDDAQLLDPL
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
Mb2515c|M.bovis_AF2122/97 GTYRLDDLPRPERVVQLCHPDLHNAFPPLRTRKVVGAHCLPAQLTRLVGR
Rv2488c|M.tuberculosis_H37Rv GTYRLDDLPRPERVVQLCHPDLHNAFPPLRTRKVVGAHCLPAQLTRLVGR
MAB_3361|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3225|M.thermoresistible__bu --------------------------------------------------
MMAR_0085|M.marinum_M --------------------------------------------------
Mvan_5449|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6828|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4504|M.gilvum_PYR-GCK --------------------------------------------------
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
MAV_2362|M.avium_104 --------------------------------------------------
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
Mb2515c|M.bovis_AF2122/97 VDEVAQVRGLLDVKRWVTLTGVGGVGKTRLATQVASAVADGYPDG--VWY
Rv2488c|M.tuberculosis_H37Rv VDEVAQVRGLLDVKRWVTLTGVGGVGKTRLATQVASAVADGYPDG--VWY
MAB_3361|M.abscessus_ATCC_1997 -----SLQTLAFVTRRLGSEPVAMLFAVR---DGTDSELAGLPE------
TH_3225|M.thermoresistible__bu -----SLQTLGFVARRLMAEPVAMVFALR---DDIHEALVGVPA------
MMAR_0085|M.marinum_M -----SVQALAFVARRIHVDPVAMVFATR---DRGPDALTGHCE------
Mvan_5449|M.vanbaalenii_PYR-1 -----SSIAIAFVARRLSAEPVGVVFATR---TVG-EELRGLPE------
MSMEG_6828|M.smegmatis_MC2_155 -----SVDVLNFVARRLSNAPLMMLCSTRTTLDGFSVQFDGLPR------
Mflv_4504|M.gilvum_PYR-GCK -----SRTAIEFAVRRLKGAFGVVVTERCVPGDGTTAGWLTLERPDGLIR
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
MAV_2362|M.avium_104 -----SATLVNQLAAWRSARLIVTIRSGEPVLDAVTALLKERLLLT----
MLBr_02341|M.leprae_Br4923 -------VLFADVVGSMDIAAAVGLERLREIMTELVSRAAG---------
Mb2515c|M.bovis_AF2122/97 VNLAPITDPALVPIAAARVLGLPDQPGRSTVDTIVRRIGDRRMLVVLDNC
Rv2488c|M.tuberculosis_H37Rv VNLAPITDPALVPIAAARVLGLPDQPGRSTVDTIVRRIGDRRMLVVLDNC
MAB_3361|M.abscessus_ATCC_1997 LTVHGLRA------ADAGTLLDSVIPG-----LLDERVRDRIVAETQGNP
TH_3225|M.thermoresistible__bu LAVPGLAD------ADARTLLEHMFPG-----AIDANVRDRLVAESRGNP
MMAR_0085|M.marinum_M LSLQGLED------HDARLVLSTAIPG-----RLNDSVAETVLAEANGNP
Mvan_5449|M.vanbaalenii_PYR-1 LVVGGLTD------DDSRELLALNLDG-----PLDTSVRDRIIVEARGNP
MSMEG_6828|M.smegmatis_MC2_155 LTMGPLEP------ADAAELLALTLRDPERSDRVDEVARQRILEQANGNP
Mflv_4504|M.gilvum_PYR-GCK VSVPPMDAG------RLHALISHRLGR-----TLTRPVVLRIAEMSGGNP
MUL_2555|M.ulcerans_Agy99 ------------------------------------------------MP
MAV_2362|M.avium_104 VHVDPFTR------EQTELLAGTVLGG-----PVDPWVVDELLQRSSGNP
MLBr_02341|M.leprae_Br4923 ---------------------------------VIERYGGTVDKFTGDGI
Mb2515c|M.bovis_AF2122/97 EHLLDGCAA----LIVALLGACPALRVLATSREPIAVAGEQIWRVPPLGH
Rv2488c|M.tuberculosis_H37Rv EHLLDGCAA----LIVALLGACPALRVLATSREPIAVAGEQIWRVPPLGH
MAB_3361|M.abscessus_ATCC_1997 LALLELPRD----MTAEELAGGFGWPDGGRLAGQIEQTFLRRVQQLPA-H
TH_3225|M.thermoresistible__bu LALLEVPRT----YAVGELAGGFVSPGAGSAPSRIEENYVHRIRALPA-Q
MMAR_0085|M.marinum_M LALLELHNA----LIRGELAGGYGLANATRTETQIERTFVSRLRALPS-E
Mvan_5449|M.vanbaalenii_PYR-1 LALLEIPRA----LGRTGLAGGFGAPG-VPLTHSLEGAFRHQLHGLPL-P
MSMEG_6828|M.smegmatis_MC2_155 MAVIELTIA----LIESGDGAPIFAGEPLPTTRRVERAFLTQLGPLSD-E
Mflv_4504|M.gilvum_PYR-GCK FYALELAHT----HVNS---GDSPPAAEPPLPATLADVVRRRVGLLDDAT
MUL_2555|M.ulcerans_Agy99 ALSANLVAS----IDRHPERITLRCDDLQSVFAELGAGPGDRVAALPGDR
MAV_2362|M.avium_104 LLLRGFLTAGRDTGALFRTAEGWQLRGPLRGDRELHDALEYRLQSLSSEE
MLBr_02341|M.leprae_Br4923 MAIFGAPTA----LEDHALRACLAALGVQEKARRLAAEVGDRDGVDLQLR
:
Mb2515c|M.bovis_AF2122/97 GEAIELFTDRAREARPELEITADNLALVTEICHRLDGIPLAIELAASRVR
Rv2488c|M.tuberculosis_H37Rv GEAIELFTDRAREARPELEITADNLALVTEICHRLDGIPLAIELAASRVR
MAB_3361|M.abscessus_ATCC_1997 TQTLLLAAATDPLGDVTLLARAAQQLGIPMHAIAPAEAADLVELST-RVR
TH_3225|M.thermoresistible__bu TRRLLLIAAAEPIGDSALFLRAAALMGIAVDALAPAEAARVIQFGP-RMR
MMAR_0085|M.marinum_M TKTFLLVAAAESTARPEWLWAAAHRLGIGPEAAAPAEAAGLIAAQG-SVR
Mvan_5449|M.vanbaalenii_PYR-1 TRRLLALAAAEPAGDASTLWRAAEVLGIETNAAVPAVEAGLAEIGS-RVR
MSMEG_6828|M.smegmatis_MC2_155 SRLLLLLIATGNGLLSEIDWAADHLGFSLTEHLGSLEESGLITVAGGRIQ
Mflv_4504|M.gilvum_PYR-GCK RTLLLGVACVADPTVELLARAHGASTDEITAGLERAEAAGIVVLEGNRVR
MUL_2555|M.ulcerans_Agy99 TRRRVCGPACELSGGRFRPSARPQSCPGLTEAASPGRSRGPLHLAR----
MAV_2362|M.avium_104 REVVEILATAGLLN---WDILRDICDAEAVAALERRGLIRLVTDGSHAVA
MLBr_02341|M.leprae_Br4923 VGLNSGQVIVGEIGSSALGYTAVGVQVGMAQRMESVAPPGVVMLSESTAR
Mb2515c|M.bovis_AF2122/97 ALALTEIVDSLHDRFRLLTGGSRIAVRRQQTMRASVDWSHALL---TGPE
Rv2488c|M.tuberculosis_H37Rv ALALTEIVDSLHDRFRLLTGGSRIAVRRQQTMRASVDWSHALL---TGPE
MAB_3361|M.abscessus_ATCC_1997 FR---------HPLVRSAVYISANPLERRRIHGVLAGATDPGA---DPDR
TH_3225|M.thermoresistible__bu FF---------HPLMRSAAYRAADPRDRRAVHRALAEATDPGA---DPDR
MMAR_0085|M.marinum_M FR---------HPLIRAAVYHSSSAAERRRVHAALAASIAGPD---DDDH
Mvan_5449|M.vanbaalenii_PYR-1 FR---------HPLIRSTAYRSVALSDRQLIHSALAAVIDREL---DPDR
MSMEG_6828|M.smegmatis_MC2_155 IR---------HPLIRSTVYGAAALASRAAVHRALAAAAT------DPAR
Mflv_4504|M.gilvum_PYR-GCK FT---------HPLLAGGVYTDAGPTARRAMHRAIASVES------HPEL
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
MAV_2362|M.avium_104 QLT--------HPMLGEAATRHAGMVRTRQLNGKLARALQKHERTGSRHL
MLBr_02341|M.leprae_Br4923 ------------------------LVEQTAVLGAPQTVRIKGAEDAVPAR
Mb2515c|M.bovis_AF2122/97 QVLFRRLAVFPSGFDLDGAQAAAAGGDVQRYEVVDLLSLLADKSLVVTDD
Rv2488c|M.tuberculosis_H37Rv QVLFRRLAVFPSGFDLDGAQAAAAGGDVQRYEVVDLLSLLADKSLVVTDD
MAB_3361|M.abscessus_ATCC_1997 RAWHRAHAAAGTDEAIAWELEQSAGRAQAKGGVLAAAAFLQRATELTADP
TH_3225|M.thermoresistible__bu RAWHAANGVTGTDDAVAAELEKSAARAQQRGGIAATATFLERAVVLTADP
MMAR_0085|M.marinum_M RVWHRAHAAEAPDAQTADDLERSAERARARGGLSAAASFLEHATKLTPDP
Mvan_5449|M.vanbaalenii_PYR-1 RAWHLGHAAIGPDDEVAAELERCATRVRARGGVAAAAAFLERASALTLDP
MSMEG_6828|M.smegmatis_MC2_155 AAWHRAEAAFGPNEEVAADLERVADRARVRGAGAEAAAALRRAAALTDDP
Mflv_4504|M.gilvum_PYR-GCK RARHLALAASSGDDEIFAALDQAADSARARGAPAAAAELMDLALGLGAHD
MUL_2555|M.ulcerans_Agy99 ---------------------CAAELTIRRGDACQAIELLRRAGELSDRP
MAV_2362|M.avium_104 RLPHLQSRIRLAEFMLHSDMEPDLDVITEAARDALAMSNVQLGEELARFA
MLBr_02341|M.leprae_Br4923 RLLRVAEPRQPTWFSESTLVGREWELATLAAMLDRSIGGRGSVVGLVGPA
:
Mb2515c|M.bovis_AF2122/97 SDGRTRYRLLETVRQYALEKLRESGDADAVRARHRDHYAAVAAGLDAPSV
Rv2488c|M.tuberculosis_H37Rv SDGRTRYRLLETVRQYALEKLRESGDADAVRARHRDHYAAVAAGLDAPSV
MAB_3361|M.abscessus_ATCC_1997 AARGRRALAAAQSKY------------DAAAFDAARELLGVADMTPLDPL
TH_3225|M.thermoresistible__bu GLRGRRALAAAQAKR------------DAADSAAAHDLLAIAERAPLSAL
MMAR_0085|M.marinum_M FVRASRALDAAMTSL------------EAGMPDSATRLVASAAAAADDEL
Mvan_5449|M.vanbaalenii_PYR-1 SNRCDRTIAAASAKA------------QAGALDVAKDLLKVADAAPMTEL
MSMEG_6828|M.smegmatis_MC2_155 QERLRRMTVAAEVAR------------SSGLIAESVRILREAEPLIREHE
Mflv_4504|M.gilvum_PYR-GCK PMRRLKAAENHFLAG---------------DTAKAAAALGEVGSIEPPIL
MUL_2555|M.ulcerans_Agy99 RRREQLLASAAFVAL------------QAAQLDEAERLLADAGLGGGASA
MAV_2362|M.avium_104 LDRGGGLPAALVLAEAVS---------WQGRGEEAGFVLAHAEPDGDDDW
MLBr_02341|M.leprae_Br4923 GIGKTRLVAEAVQLA---------------KGLEVEVFSVFCESHATDVA
Mb2515c|M.bovis_AF2122/97 AGHERRLNQAELEIDNLRAAFAFSRENGDTGHALLLASCLQPLWRARGRL
Rv2488c|M.tuberculosis_H37Rv AGHERRLNQAELEIDNLRAAFAFSRENGDTGHALLLASCLQPLWRARGRL
MAB_3361|M.abscessus_ATCC_1997 ARARATRLRAKIAFAESRVGAFGSVTVSEAAIGLVEAARCLENLDDNLAR
TH_3225|M.thermoresistible__bu EWARAVHLRAQLEFARSRAGDAGGPPVGQTAAALLTAAQLLQDVDAPAAR
MMAR_0085|M.marinum_M IAARCELIRAKIAFAASRG--------SDAPPLLLAAAQRMQRLDPSESR
Mvan_5449|M.vanbaalenii_PYR-1 QRAQADLVRAQLAFISNHG--------NDAAPLLLGAARRLESIDPTLAR
MSMEG_6828|M.smegmatis_MC2_155 SETPLAITRFVLNATAATP--------GQSADELLALSRKIADDDPGRRQ
Mflv_4504|M.gilvum_PYR-GCK RAMATSLLATVRMYDNEHR----------QAVDLLRSALDDAADNVPVQV
MUL_2555|M.ulcerans_Agy99 SALLISSFISLYRYGDVTA----------THRRLVERLQSADDLDGETLT
MAV_2362|M.avium_104 LIARWGCLRAANLFWGCGD--------AEAARREADTVKKRVSSEAGLHL
MLBr_02341|M.leprae_Br4923 FDVVAQLVRAVAQISGLDD---------RSARARVREQIPDADTQDLLLL
Mb2515c|M.bovis_AF2122/97 QEGLAWFAAALADHDAHP--AGADPGLYARALADRALIDAVAGITDRLDD
Rv2488c|M.tuberculosis_H37Rv QEGLAWFAAALADHDAHP--AGADPGLYARALADRALIDAVAGITDRLDD
MAB_3361|M.abscessus_ATCC_1997 ETYLDAVGAAMYGGRLCP--RGGAVEVAEPARLAPAGAQP-ARPSDLLLD
TH_3225|M.thermoresistible__bu ESYLEAFAALMYAGRLAP--SGALLEAADAVQAAFARAPEGSRAVDAFCQ
MMAR_0085|M.marinum_M KAYLGAVLASILVGRMATDQHNSSPSVAKAASNAPAAPHP-PRALDVLLD
Mvan_5449|M.vanbaalenii_PYR-1 ETYLDTLSAAIFAGRLAV--DGGVLEVSEAASAATRSLNT-PGAADLLLD
MSMEG_6828|M.smegmatis_MC2_155 LLWAAAIECRMHG------------LPEHSRRDVVAEIGRLDDDPHDPLT
Mflv_4504|M.gilvum_PYR-GCK QVLLRLSFALNSIGELDD-----ARRYARDAVKLAEELGFPGATSAALAW
MUL_2555|M.ulcerans_Agy99 RMVNLLLAVSMFAADPAL---------WQITDGLVDSLADRLGELSVIYR
MAV_2362|M.avium_104 IDALELSMAFFRGDVETT---------TELGPGLCESDAVPMATTWAAVP
MLBr_02341|M.leprae_Br4923 DDLLGIADPAVELPRLDP---------DARRRRLTALINVAQLALSRPAV
Mb2515c|M.bovis_AF2122/97 AQKALAIARDIEDPALLARALTACGGVAAYNADLARPWLAEAVGLARAVG
Rv2488c|M.tuberculosis_H37Rv AQKALAIARDIEDPALLARALTACGGVAAYNADLARPWLAEAVGLARAVG
MAB_3361|M.abscessus_ATCC_1997 GLARRITHGAAASAQTLGEALTLIRCEAD-RPANTS-WMEQAFPIALES-
TH_3225|M.thermoresistible__bu GMTQRIVGGISAAAAPLRVALTAMCELARSRPAEVVHWLVPAFPVLQES-
MMAR_0085|M.marinum_M GLVIRLTEGYVAAAPRLRSAIREYLRERDIGVAEPG-WHDLTARVCLD--
Mvan_5449|M.vanbaalenii_PYR-1 GMTTQHSAGFEKGLPNVREALRIYG--PGMTTEQELRWMFLACVAAAH--
MSMEG_6828|M.smegmatis_MC2_155 AIALALADDTGKGAG-LRARLPQLVDTVGDSPLLMLSLAFAAEAVTDR--
Mflv_4504|M.gilvum_PYR-GCK AVHVDFQCGRGLDETALARAMKLYDSTFDVPIIFRAPFVHALAMSWTGR-
MUL_2555|M.ulcerans_Agy99 DAWADAARRGRTVTQRLKEQLDRLAELEPWDVMRVALAGYYVDLIDDFR-
MAV_2362|M.avium_104 TCAALAATGRYSEVGRIADIGVRAAMSCGMGLHRFNIGISEIIAATDAG-
MLBr_02341|M.leprae_Br4923 FVVEDVHWIDEVSDSMLADFLAVIPQTRSMALVTYRPEYHGALRHVVG--
:
Mb2515c|M.bovis_AF2122/97 DKWRLAEVLAWQAYVGFAGEGDPGATRAAGEEARSLADEIGDAFLSRSCR
Rv2488c|M.tuberculosis_H37Rv DKWRLAEVLAWQAYVGFAGEGDPGATRAAGEEARSLADEIGDAFLSRSCR
MAB_3361|M.abscessus_ATCC_1997 ---------------ATHEVWDDDMWHHLATRAVHIAREVGALSLLPAAL
TH_3225|M.thermoresistible__bu ---------------AGHELWDENLVDALSEAVVRQARDAGALAGLPQAL
MMAR_0085|M.marinum_M -------------------LFDQDAYNFLAARQVEDLRAAGALTMLPVAL
Mvan_5449|M.vanbaalenii_PYR-1 -------------------VWDLDRLMSLAVRHVQLSRDTGAVSELPLAL
MSMEG_6828|M.smegmatis_MC2_155 -----------------------AGALKCWTHVQNQARNCGSLAEECEGL
Mflv_4504|M.gilvum_PYR-GCK ----------------------LEQAHQELTAVRGVCLERGAESDMMAIA
MUL_2555|M.ulcerans_Agy99 ---------------------------SVLVPLADREIEGGAATIALATL
MAV_2362|M.avium_104 -----------------------DDRAAERIYKRYAAMAEGLPGAEAMVD
MLBr_02341|M.leprae_Br4923 -------------------------AQIIAVAPLSDVETSTLVAELLGLD
Mb2515c|M.bovis_AF2122/97 WALAAANLWQGNLEAAVGLSREVIGESDAAHDMVSSCAGQACLAHALAHR
Rv2488c|M.tuberculosis_H37Rv WALAAANLWQGNLEAAVGLSREVIGESDAAHDMVSSCAGQACLAHALAHR
MAB_3361|M.abscessus_ATCC_1997 IYRAGMHVHAGELDAAAELVQEADAISAATGH-APIRYHSLILA---AWR
TH_3225|M.thermoresistible__bu VYRAGVHLLFGEFGLADTLLTEAESITAATDHRGPVRYHRLIIA---AWR
MMAR_0085|M.marinum_M VTFAGVCVSAGNFGQADALLDESAAIIAATGA-PPRPAIKTYLA---AYR
Mvan_5449|M.vanbaalenii_PYR-1 SCLITPLLFTGRFGEAARAIDELTAAIDAMGN-NLTPYGALSLA---AMS
MSMEG_6828|M.smegmatis_MC2_155 RGAANILLTEGHVEAAAMSAQTALHMAESMNIAMTAGSAAAILARALVWQ
Mflv_4504|M.gilvum_PYR-GCK GFLAINHLWRGQITDAEAEAAEAVERAEQLGGDDVLIIPMTVRGAIAAYA
MUL_2555|M.ulcerans_Agy99 ALVAAYQLASGQWAEAVDTSQRGVALCSQHHYELFGYQLRGYLGVISACR
MAV_2362|M.avium_104 AMLGVVRLARGEFPAACAAFTRSISLFAKGFPSPWLVVVGAFQAQAEGAR
MLBr_02341|M.leprae_Br4923 QSVTQIGELITERAAGNPFFAQEITRELAERGVLTGERGRYACSTDVAEV
. . .
Mb2515c|M.bovis_AF2122/97 G--DTEAAAAAQASIDTAVGLSPVLSGSACSALVFATLAAGDVAAAEHAR
Rv2488c|M.tuberculosis_H37Rv G--DTEAAAAAQASIDTAVGLSPVLSGSACSALVFATLAAGDVAAAEHAR
MAB_3361|M.abscessus_ATCC_1997 GSEPTAIRLIDEAMRDGAARGEGRLLGAMGYAAGVLNNSLGRYELAFMAA
TH_3225|M.thermoresistible__bu GDAVEAARLIEAAAADGEARGEGRLMGLTGYAAALLYNGIGRYREALAAA
MMAR_0085|M.marinum_M GQEQICREGVQQTVDSAASRGEGYDVSVAMYAAAILHNGLGQYQEAFNAA
Mvan_5449|M.vanbaalenii_PYR-1 GRRDHLQRLGSTAIHNAEHRGEGIGLTVNAWATALLENGHGRYHAAAEAA
MSMEG_6828|M.smegmatis_MC2_155 GQGERARHVLDRARHHLSPAPTILWNDDVHWAAGLAALCEADHTQALGHL
Mflv_4504|M.gilvum_PYR-GCK GRVDDARADARWVLAAVRNRKASHIADWPGMTLCFLEESLGNHREALAAL
MUL_2555|M.ulcerans_Agy99 GDVVRARELAAQVRVWAEPRRVGFLTGAVAQIAILCSFAEGDYESAYLQA
MAV_2362|M.avium_104 GDSTAAAAALWRADRAYGP-HAAVFLPELELARAWERAAAGDTQAATTHA
MLBr_02341|M.leprae_Br4923 CVPATLQATIAARIDRLSPPAKQLLVAAAVIGFRFGSDLLASLGIDLSVD
.
Mb2515c|M.bovis_AF2122/97 ESATRFFG--ASAAAIINDPTSSAQISCARGDLNAAHRLADGAASITRGV
Rv2488c|M.tuberculosis_H37Rv ESATRFFG--ASAAAIINDPTSSAQISCARGDLNAAHRLADGAASITRGV
MAB_3361|M.abscessus_ATCC_1997 RRACEH----EDLGLYSWCLIELIEAAVRCGEHDTAVKAFGQLEERALAA
TH_3225|M.thermoresistible__bu RTTCEY----EDLGFYSWCLHELVEAAARVGETDTAHRALGDIEERAGAS
MMAR_0085|M.marinum_M ASGARY----DDVGMCGYLLGELIEAAVRCKEHNAATEALGRLLKRTKAS
Mvan_5449|M.vanbaalenii_PYR-1 VYATSYP---GDCTSAGWALIELVEAGSRTGDDAVASAALERLTEMTTPS
MSMEG_6828|M.smegmatis_MC2_155 TQMTLH------RTSRRWAIADLAEAAAGAEKADIARPLLAEAEEQAERL
Mflv_4504|M.gilvum_PYR-GCK DDSFIAAGPPTTELMYAWHLPDAIEAMVGVGRLDDAEILTAALERNGVEH
MUL_2555|M.ulcerans_Agy99 TAITAPGEFPPLALHATRTLFDLVEAAVHTDRLNEARRHVRAAKRLQFAD
MAV_2362|M.avium_104 TQAAEIAR----AAGMHAAEMRTRHAAVRFGDR----SQTARLERLARIL
MLBr_02341|M.leprae_Br4923 ELIDAN-------------LVDQVRFTAPVEYAFRHPLIRTVAYESQLKS
.
Mb2515c|M.bovis_AF2122/97 HRARALTTRCRIEIAQ----GDRHRAERDAHDALGVAASIGAYLWVPDIL
Rv2488c|M.tuberculosis_H37Rv HRARALTTRCRIEIAQ----GDRHRAERDAHDALGVAASIGAYLWVPDIL
MAB_3361|M.abscessus_ATCC_1997 QSDWSQGMVARSRALI----TVGHDAEPHYREAIQRLTNTRISAHLARAH
TH_3225|M.thermoresistible__bu GTPWGLGALAGARALL----ADGDEADRLFREALDHLSRSRVVVHRARVH
MMAR_0085|M.marinum_M GTPTALGIGASATALV----SDGSIADAAYREAITHLRRSPVAVHLARTH
Mvan_5449|M.vanbaalenii_PYR-1 GTDWGLGVEARSRALT----TEGDAAEALYLEAIERLGRAGMGPDQGRAH
MSMEG_6828|M.smegmatis_MC2_155 GIDSFLVHRAHALLAD----SVAE-SEDRFRAALGAAERTGAELESARTH
Mflv_4504|M.gilvum_PYR-GCK DRRWMRAVGARCRAMLLAAHGDVAAAEQMAHRAISEHDHLPMPFERARTR
MUL_2555|M.ulcerans_Agy99 APPRLAIATGAAEALC----ASDERAPALFEKVLGHPAVASFPFEHARIR
MAV_2362|M.avium_104 DTPLAEAAADHARGLT------QRDGDLLDAAAQQFADLGALACAADAAA
MLBr_02341|M.leprae_Br4923 DRARLHRRLAAAIEAR-----------APHSVDQHAVLIAEHLEAAGDLH
Mb2515c|M.bovis_AF2122/97 ECLASVMADAGSNREAVRLFGAADAARGRMGAVRFGIYQAGCNSSLATLR
Rv2488c|M.tuberculosis_H37Rv ECLASVMADAGSNREAVRLFGAADAARGRMGAVRFGIYQAGCNSSLATLR
MAB_3361|M.abscessus_ATCC_1997 LIYGEWLRRCNRRSDARTELTAAHGSFVNMGTAAFAERAE----------
TH_3225|M.thermoresistible__bu LTYGEWLRREHRRGEARRELNEAHGMFTRMGAQGFAERSR----------
MMAR_0085|M.marinum_M LTYGEWLRRERRRSEARSQLRIAYDMFAQMGAAGFAERAR----------
Mvan_5449|M.vanbaalenii_PYR-1 LLYGEWLRRRRRRVDARAQLRSAHHLFDSIGMDAFAERAR----------
MSMEG_6828|M.smegmatis_MC2_155 LLYGVWLRRRRRIVDARVHLSAALTAFDRAGAVPFAERAA----------
Mflv_4504|M.gilvum_PYR-GCK LLLGQLQRRLRQKATAAKNLTDALHTFEQLGTPLWAQRAR----------
MUL_2555|M.ulcerans_Agy99 LAYGMRLRRLRRYRNARVVLRAAAEIFAGLGAEPWTQRAR----------
MAV_2362|M.avium_104 QAAGEHARRGDRGK------KFESSAWAHALASRYELHTP----------
MLBr_02341|M.leprae_Br4923 AAYGWHMRAAAWATNQDVRAARVSWEHATKIADALTAEDP----------
.
Mb2515c|M.bovis_AF2122/97 KSMGDSEFDDAWAEGTALSIDEAIAYAQRGRGARKRPTSGWG----ALTP
Rv2488c|M.tuberculosis_H37Rv KSMGDSEFDDAWAEGTALSIDEAIAYAQRGRGARKRPTSGWG----ALTP
MAB_3361|M.abscessus_ATCC_1997 -----------------------RELRATGAKVRKRSASSE----KALTA
TH_3225|M.thermoresistible__bu -----------------------RELIAVGEKVRRQPLTSG----DELTA
MMAR_0085|M.marinum_M -----------------------RELSATGEAVYVQPTGIT----VDLTT
Mvan_5449|M.vanbaalenii_PYR-1 -----------------------VELLATGETAQKRTNSRV----AALTA
MSMEG_6828|M.smegmatis_MC2_155 -----------------------AELRAAGVTSAPRPGTHSGADAGALTP
Mflv_4504|M.gilvum_PYR-GCK -----------------------SELARAVVAPAEG-----------LTP
MUL_2555|M.ulcerans_Agy99 -----------------------NELRAAGTAVRHSAAVGP----APLTA
MAV_2362|M.avium_104 ---------------------------AVEAAARPLP----------FSG
MLBr_02341|M.leprae_Br4923 --------------------------HRAAMCIAPRTRLCG----IAWRG
Mb2515c|M.bovis_AF2122/97 TELEVALLVGEGLSNKEIGVRLFISPRTVHSHLTHVYTKLGLSSRLQLAQ
Rv2488c|M.tuberculosis_H37Rv TELEVALLVGEGLSNKEIGVRLFISPRTVHSHLTHVYTKLGLSSRLQLAQ
MAB_3361|M.abscessus_ATCC_1997 QEAQIARMAGQGLTNQEIAAQLFISSHTVEWHLRKVFAKRGITSRRQLRS
TH_3225|M.thermoresistible__bu QEAQIAGLAADGLTNQEIGAQLFLSVHTVEWHLRKVFVKLGITSRRQLRA
MMAR_0085|M.marinum_M QESHIARLARDGYTNAEIAGLLFISARTVEWHLSKIFAKLGVTSRRELRA
Mvan_5449|M.vanbaalenii_PYR-1 QEAQIARLARDGLSNPEIGARLFISARTVQYHLSKVFAKLGIRSRSQLEH
MSMEG_6828|M.smegmatis_MC2_155 QELQIAQMAAAGMTNREIADRIYLSHRTVAAHLYKVFPKLGITRRNQLHA
Mflv_4504|M.gilvum_PYR-GCK SEQKVAEMAAAGATNKDIAAAMFISSKTVEHNLTRIYRKLGISSRAELGR
MUL_2555|M.ulcerans_Agy99 QERLVAELAAKGLSNKEIAARLCLSPRTVGAHLYRLFPKLGVTNRAGLHD
MAV_2362|M.avium_104 RERQIVNLVAAGLSNREIADRLVISVRTVEGHLYRLFTKLGINSREQLTL
MLBr_02341|M.leprae_Br4923 RFNSSSGFDEVRQLCNATGDKAPLAVATVGPAIDHVYQDRLH--------
: . :: ** : ::: .
Mb2515c|M.bovis_AF2122/97 QAARRGESERGPSRP----------------
Rv2488c|M.tuberculosis_H37Rv QAARRGESERGPSRP----------------
MAB_3361|M.abscessus_ATCC_1997 GR-----------------------------
TH_3225|M.thermoresistible__bu APRVTATW-----------------------
MMAR_0085|M.marinum_M ILMESP-------------------------
Mvan_5449|M.vanbaalenii_PYR-1 SLPELAT------------------------
MSMEG_6828|M.smegmatis_MC2_155 ALGAPTGIA----------------------
Mflv_4504|M.gilvum_PYR-GCK RMDQPGL------------------------
MUL_2555|M.ulcerans_Agy99 ALDAIHAAPDQI-------------------
MAV_2362|M.avium_104 LVAREPRGRRELLGHSNPSLGDQDDVHPHAG
MLBr_02341|M.leprae_Br4923 -------------------------------