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MVQVSGVSRDDGPVAGLIGRRDECAVLDQLVDAVAGGASRALMIRGEAGVGKTALLDYAAARAAELQIAR IVGIQSEMELAFAGIHQLCLPLLPRLGHLPVPQRDALEVALGMATGSSPDRFLVGLAVLNLLADAAADRP LLCLVDDEQWLDRSSAQVLAFVARRLGSESVGMIFAAREPSDAAAGVPALVVRGLRGADARALLDSALSA PLDPRVRDQILAETDGNPLALLELPRTLTRDALAGVFGLPGGSGVAADIEHAFGVRIGELPEPTRDLLLI AAAEPTGDAPLVWRAAARLGIGSDAAAPAVEAELASFDTRVTFQHPLVRSVVYRAAALDDRRRAHRALAA ATDAEVDPDRRAWHLAHAAAGPDAAAAAELESSAARARSRGGACAAAAFLERATALTVDPVLRNDRALAA AAAKAEAGAFESAQDLLAMVEATSLSDLQQAQVDVLRARLAFVTSHGSDAPPLLLKAARRLGGIDPDRAR AVYLDAMLAAMFAGRLATGANLVEVAAAARSAPERSGAAEVSDLLLDWLTAHYGRGYVAARSALGDVLSA FDGEADDLPLNRMLLASTAAHYAWDDVRLDVFTAHHVERARATGALSEVPIALNSRAIALLFFGDLDGAA DAVDEIQAADDATGALLAPYAEVGLAAMRGDLARTASLVDATVAAVTARGEGNGLTVAWWAEAVLHNGFG SARKALEAASRAAAFPPELASANWALIELVEAATRCGAVETAAEAAADLAELTTSSGTDWALGLAARARA LVSGPAESERWYLESIERLENTRARAELARSRLVYGEWLRRERRRTAARSELRTAHEMFSAMGMSAFAAR AQRELAAAGDRIRETVIAAVDHRLTAQEAHIARLARDGLSNPEIGARLFISARTVQYHLGKVFTKLGITS RSQLDGVLGHVTDR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3290 | - | - | 100% (924) | regulatory protein |
| M. smegmatis MC2 155 | MSMEG_0321 | - | 0.0 | 48.91% (916) | transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_4053 | - | 0.0 | 43.97% (912) | transcriptional regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2515c | - | 1e-15 | 26.18% (974) | LuxR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1156 | - | 3e-64 | 30.85% (927) | regulatory protein, LuxR |
| M. tuberculosis H37Rv | Rv2488c | - | 1e-15 | 26.18% (974) | LuxR family transcriptional regulator |
| M. leprae Br4923 | MLBr_02341 | - | 7e-19 | 26.34% (429) | putative regulatory protein |
| M. abscessus ATCC 19977 | MAB_3361 | - | 0.0 | 50.00% (888) | LuxR family transcriptional regulator |
| M. marinum M | MMAR_0085 | - | 0.0 | 44.99% (918) | transcriptional regulatory protein |
| M. avium 104 | MAV_0578 | - | 8e-23 | 25.16% (950) | transcriptional regulator, LuxR family protein |
| M. thermoresistible (build 8) | TH_3225 | - | 0.0 | 48.55% (933) | PUTATIVE regulatory protein, LuxR |
| M. ulcerans Agy99 | MUL_2555 | - | 2e-25 | 28.83% (555) | hypothetical protein MUL_2555 |
| M. vanbaalenii PYR-1 | Mvan_5449 | - | 0.0 | 51.55% (906) | regulatory protein, LuxR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2515c|M.bovis_AF2122/97 MDRRPRDFEQSRRRCRCNALRAGSMLASMSKIHPGVDVVPVDWSADGVSE
Rv2488c|M.tuberculosis_H37Rv MDRRPRDFEQSRRRCRCNALRAGSMLASMSKIHPGVDVVPVDWSADGVSE
MSMEG_3290|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5449|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3225|M.thermoresistible__bu --------------------------------------------------
MMAR_0085|M.marinum_M --------------------------------------------------
Mflv_1156|M.gilvum_PYR-GCK --------------------------------------------------
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
MAV_0578|M.avium_104 --------------------------------------------------
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
Mb2515c|M.bovis_AF2122/97 LVPTGTVTLLLADIEGATHLPGSQLDTTAIAKLDRTLTELVREHRGVCPV
Rv2488c|M.tuberculosis_H37Rv LVPTGTVTLLLADIEGATHLPGSQLDTTAIAKLDRTLTELVREHRGVCPV
MSMEG_3290|M.smegmatis_MC2_155 ---MVQVSGVSRDDGPVAGLIGRRDECAVLDQLVDAVAGGASRALMIR--
Mvan_5449|M.vanbaalenii_PYR-1 --MTSSAQPIRPSQESQVELVGRRAERRALDGVLSAVSAGRSGVLVLSGV
MAB_3361|M.abscessus_ATCC_1997 ---------------------------------------------MLR--
TH_3225|M.thermoresistible__bu ----------MSSRDGDVVLHGRAAEIATLRDVMSTARAGSSRVLVLH--
MMAR_0085|M.marinum_M --------------MPTVTLVGRHREQQQLQQLLDAARRGESGVLVLR--
Mflv_1156|M.gilvum_PYR-GCK --------------------------MKAVDDFLAGLQQLQPAGLLIE--
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
MAV_0578|M.avium_104 -------------MIGGELLIGRDSELAAIRRALNGADHHRG--VVIA--
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
Mb2515c|M.bovis_AF2122/97 EQGEGDSFLVAFARASDAVACALGLQRAPLAPIRLRIGMHTGEVSSPDEG
Rv2488c|M.tuberculosis_H37Rv EQGEGDSFLVAFARASDAVACALGLQRAPLAPIRLRIGMHTGEVSSPDEG
MSMEG_3290|M.smegmatis_MC2_155 ----GEAGVGKTALLDYAAARAAELQIARIVGIQSEM-------------
Mvan_5449|M.vanbaalenii_PYR-1 LVLSGEAGIGKTALLDEVAGQIAEGLLVRVAGVESET-------------
MAB_3361|M.abscessus_ATCC_1997 ----GQAGVGKTALLRYVLGKASGQLIAQASGIQSEM-------------
TH_3225|M.thermoresistible__bu ----GEAGVGKTALLGQLLGDAAGMRCVQVAGVESDM-------------
MMAR_0085|M.marinum_M ----GDAGIGKTTLLTDLVDNAPDLRVLRVRGAEMEM-------------
Mflv_1156|M.gilvum_PYR-GCK ----GEAGIGKTTMLAGVVDAARQAGFRVLSAHGDQSG------------
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
MAV_0578|M.avium_104 ----GAAGVGKTWLARAALRRAGASGEQ----------------------
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
Mb2515c|M.bovis_AF2122/97 NCVGPTIDRTARLRELAHGGQTVLSGTTSDLVADLLPKDAWLNDLGTYRL
Rv2488c|M.tuberculosis_H37Rv NCVGPTIDRTARLRELAHGGQTVLSGTTSDLVADLLPKDAWLNDLGTYRL
MSMEG_3290|M.smegmatis_MC2_155 --------------ELAFAGIHQLCLP------------------LLPRL
Mvan_5449|M.vanbaalenii_PYR-1 --------------EFAYAALHQLCIP------------------LFERI
MAB_3361|M.abscessus_ATCC_1997 --------------ELAFAGLQQFCAP------------------LTKYS
TH_3225|M.thermoresistible__bu --------------ELAYAGLHQLCAP------------------LLDRL
MMAR_0085|M.marinum_M --------------ELTYSGVQQLCGP------------------LMSLI
Mflv_1156|M.gilvum_PYR-GCK -------------SGLAHAAIADLFAG-----------------VQTDIL
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
MAV_0578|M.avium_104 ----------------------------------------------IKWI
MLBr_02341|M.leprae_Br4923 --------------------------------------------------
Mb2515c|M.bovis_AF2122/97 DDLPRPERVVQLCHPDLHNAFPPLRTRKVVGAHCLPAQLTRLVGRVDEVA
Rv2488c|M.tuberculosis_H37Rv DDLPRPERVVQLCHPDLHNAFPPLRTRKVVGAHCLPAQLTRLVGRVDEVA
MSMEG_3290|M.smegmatis_MC2_155 GHLPVPQRDALEVALGMATGSSPDR-------FLVGLAVLNLLADAAADR
Mvan_5449|M.vanbaalenii_PYR-1 EQIPGPQRAALLTAFGQRRSPTPDP-------FLVGLAVLSLVSEFVHQC
MAB_3361|M.abscessus_ATCC_1997 GAIPDPQREALTIAFGTRSGPPPDR-------FLIGLAVLSLLAAAAEHQ
TH_3225|M.thermoresistible__bu DDLPSPQRDVLNVAFGRGAGPAPGR-------FLVGLAVLNLLAAAGADQ
MMAR_0085|M.marinum_M GQLPEPQLDALEIALGRKRGRAPDR-------LLLGLAVLTLVGEASRAS
Mflv_1156|M.gilvum_PYR-GCK DGLPELQRRAADGVLRRGDGTGGPT-----DERVIAAALLGAVHGSATRT
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
MAV_0578|M.avium_104 VGTQSAQALPLGAFIGLLGDAMSEP-------LTSVRRVIETFVARQRRG
MLBr_02341|M.leprae_Br4923 ----------------------------------MTTALVCVACGAELRS
Mb2515c|M.bovis_AF2122/97 QVRGLLDVKRWVTLTGVGGVGKTRLATQVASAVADGYPDGVWYVNLAP--
Rv2488c|M.tuberculosis_H37Rv QVRGLLDVKRWVTLTGVGGVGKTRLATQVASAVADGYPDGVWYVNLAP--
MSMEG_3290|M.smegmatis_MC2_155 PLLCLVDDEQWLDRSSAQVLAFVARRLGSESVGMIFAARE-PSDAAAG--
Mvan_5449|M.vanbaalenii_PYR-1 PVFLIIDDQQWLDRASSIAIAFVARRLSAEPVGVVFATRT-VGEELRG--
MAB_3361|M.abscessus_ATCC_1997 PVLCVIDDAQWLDRVSLQTLAFVTRRLGSEPVAMLFAVRDGTDSELAG--
TH_3225|M.thermoresistible__bu PLLCVIDDAQWLDRVSLQTLGFVARRLMAEPVAMVFALRDDIHEALVG--
MMAR_0085|M.marinum_M PILCVVDDAQWVDSASVQALAFVARRIHVDPVAMVFATRDRGPDALTG--
Mflv_1156|M.gilvum_PYR-GCK PVLVAVDDVQWLDPSSVAVLAFVARRVKG-RVGFVVAERPGVGPGLPA--
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
MAV_0578|M.avium_104 RVVVGVDDAHLLDGLSALVVHQLAQSGGVRLVVTVRTGSHQPDAVTALWK
MLBr_02341|M.leprae_Br4923 -------IAKFCDECGSPVVEAETPAEYKQVTVLFADVVGSMDIAAAVG-
Mb2515c|M.bovis_AF2122/97 ---ITDPALVPIAAARVLGLPDQPGRSTVDTIVRRIGDRRMLVVLDNCEH
Rv2488c|M.tuberculosis_H37Rv ---ITDPALVPIAAARVLGLPDQPGRSTVDTIVRRIGDRRMLVVLDNCEH
MSMEG_3290|M.smegmatis_MC2_155 ---VPALVVRGLRGADARALLDSALSAPLDPRVR---DQILAETDGNPLA
Mvan_5449|M.vanbaalenii_PYR-1 ---LPELVVGGLTDDDSRELLALNLDGPLDTSVR---DRIIVEARGNPLA
MAB_3361|M.abscessus_ATCC_1997 ---LPELTVHGLRAADAGTLLDSVIPGLLDERVR---DRIVAETQGNPLA
TH_3225|M.thermoresistible__bu ---VPALAVPGLADADARTLLEHMFPGAIDANVR---DRLVAESRGNPLA
MMAR_0085|M.marinum_M ---HCELSLQGLEDHDARLVLSTAIPGRLNDSVA---ETVLAEANGNPLA
Mflv_1156|M.gilvum_PYR-GCK ---ATWLQVG--TGALTRLPVAPMSLGALHTMLSSRLGRRFSRPQIVRIA
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
MAV_0578|M.avium_104 DDLLTRLDLEPLSAAATREVIESTLGGPVDARCAARFRRLTGGNTLFLRQ
MLBr_02341|M.leprae_Br4923 ---LERLREIMTELVSRAAGVIERYGGTVDKFTG-----------DGIMA
Mb2515c|M.bovis_AF2122/97 LLDGCAALIVALLGACPA-LRVLATSREPIAVAGEQIWRVPPLGHGEAIE
Rv2488c|M.tuberculosis_H37Rv LLDGCAALIVALLGACPA-LRVLATSREPIAVAGEQIWRVPPLGHGEAIE
MSMEG_3290|M.smegmatis_MC2_155 LLELPRTLTRDALAGV---FGLPGGSGVAADIEHAFGVRIGELPEPTRDL
Mvan_5449|M.vanbaalenii_PYR-1 LLEIPRALGRTGLAGG---FGAPG-VPLTHSLEGAFRHQLHGLPLPTRRL
MAB_3361|M.abscessus_ATCC_1997 LLELPRDMTAEELAGG---FGWPDGGRLAGQIEQTFLRRVQQLPAHTQTL
TH_3225|M.thermoresistible__bu LLEVPRTYAVGELAGG---FVSPGAGSAPSRIEENYVHRIRALPAQTRRL
MMAR_0085|M.marinum_M LLELHNALIRGELAGG---YGLANATRTETQIERTFVSRLRALPSETKTF
Mflv_1156|M.gilvum_PYR-GCK EVSGGNPLYALELARVADGAGSRPGQRLPESLSELVRLRVDGLAEDVRDV
MUL_2555|M.ulcerans_Agy99 ------------------------------------------MPALSANL
MAV_0578|M.avium_104 LLSDQMAAGRMRRVAG--VWMWDGDVAVSASLSDTVGRQLGRLTPPLALV
MLBr_02341|M.leprae_Br4923 IFGAPTALEDHALRAC----------LAALGVQEKARRLAAEVGDRDGVD
:
Mb2515c|M.bovis_AF2122/97 LFTDRAREARPELEITADNLALVTEICHRLDGIPLAIELAASRVRALALT
Rv2488c|M.tuberculosis_H37Rv LFTDRAREARPELEITADNLALVTEICHRLDGIPLAIELAASRVRALALT
MSMEG_3290|M.smegmatis_MC2_155 LLIAAAEPTG--------DAPLVWRAAARLG-IGSDAAAPAVEAELASFD
Mvan_5449|M.vanbaalenii_PYR-1 LALAAAEPAG--------DASTLWRAAEVLG-IETNAAVPAVEAGLAEIG
MAB_3361|M.abscessus_ATCC_1997 LLAAATDPLG--------DVTLLARAAQQLG-IPMHAIAPAEAADLVELS
TH_3225|M.thermoresistible__bu LLIAAAEPIG--------DSALFLRAAALMG-IAVDALAPAEAARVIQFG
MMAR_0085|M.marinum_M LLVAAAESTA--------RPEWLWAAAHRLG-IGPEAAAPAEAAGLIAAQ
Mflv_1156|M.gilvum_PYR-GCK LLVAASATSP--------TVDLLAKAVGVTPAAVTGLVEAAEVEGIVVID
MUL_2555|M.ulcerans_Agy99 VASIDRHPER-----------ITLRCDDLQSVFAELGAGPGDRVAALPGD
MAV_0578|M.avium_104 VDTLSQCEPLP--------VDLLCDLASREDLVAAEAMGLVTVERTPRAL
MLBr_02341|M.leprae_Br4923 LQLRVGLNSG----------------QVIVGEIGSSALGYTAVGVQVGMA
:
Mb2515c|M.bovis_AF2122/97 -EIVDSLHDRFRLLTGGSRIAVRRQQTMRASVDWSHALLTGPEQVLFR-R
Rv2488c|M.tuberculosis_H37Rv -EIVDSLHDRFRLLTGGSRIAVRRQQTMRASVDWSHALLTGPEQVLFR-R
MSMEG_3290|M.smegmatis_MC2_155 -TRVTFQHPLVRSVVYRAAALDDRRRAHRALAAATDAEVDPDRRAWHL-A
Mvan_5449|M.vanbaalenii_PYR-1 -SRVRFRHPLIRSTAYRSVALSDRQLIHSALAAVIDRELDPDRRAWHL-G
MAB_3361|M.abscessus_ATCC_1997 -TRVRFRHPLVRSAVYISANPLERRRIHGVLAGATDPGADPDRRAWHR-A
TH_3225|M.thermoresistible__bu -PRMRFFHPLMRSAAYRAADPRDRRAVHRALAEATDPGADPDRRAWHA-A
MMAR_0085|M.marinum_M -GSVRFRHPLIRAAVYHSSSAAERRRVHAALAASIAGPDDDDHRVWHR-A
Mflv_1156|M.gilvum_PYR-GCK GNRIRFTHPVLANGIYAGADPQRRREVHRRLADLKT---DPELRARHL-A
MUL_2555|M.ulcerans_Agy99 RTRRRVCGPACELSGGRFRPSAR-----------------PQSCPGLT-E
MAV_0578|M.avium_104 --MARLAHPLFGELRRAGAGEMYLSTIRGRLATRLAQDQDADMQATVRRA
MLBr_02341|M.leprae_Br4923 QRMESVAPPGVVMLSESTARLVEQTAVLGAPQTVRIKGAEDAVPARRLLR
Mb2515c|M.bovis_AF2122/97 LAVFPSGFDLDGAQAAAAGGDVQRYEVVDLLSLLADKSLVVTDDSDGRTR
Rv2488c|M.tuberculosis_H37Rv LAVFPSGFDLDGAQAAAAGGDVQRYEVVDLLSLLADKSLVVTDDSDGRTR
MSMEG_3290|M.smegmatis_MC2_155 HAAAGPDAAAAAELESSAARARSRGGACAAAAFLERATALTVDPV-----
Mvan_5449|M.vanbaalenii_PYR-1 HAAIGPDDEVAAELERCATRVRARGGVAAAAAFLERASALTLDPS-----
MAB_3361|M.abscessus_ATCC_1997 HAAAGTDEAIAWELEQSAGRAQAKGGVLAAAAFLQRATELTADPA-----
TH_3225|M.thermoresistible__bu NGVTGTDDAVAAELEKSAARAQQRGGIAATATFLERAVVLTADPG-----
MMAR_0085|M.marinum_M HAAEAPDAQTADDLERSAERARARGGLSAAASFLEHATKLTPDPF-----
Mflv_1156|M.gilvum_PYR-GCK LASTVADETTLTTLDAAADAARARGAPAAAAELLEWAMQLGGDSVS----
MUL_2555|M.ulcerans_Agy99 AASPGRSRGPLHLARCAAELTIRRGDACQAIELLRRAGELSDRPR-----
MAV_0578|M.avium_104 LLTLESDLDPQPELYLESARHAMTLLDLDLADRLANAAARAGAPG-----
MLBr_02341|M.leprae_Br4923 VAEPRQPTWFSESTLVGREWELATLAAMLDRSIGGRGSVVGLVGPAG---
Mb2515c|M.bovis_AF2122/97 YRLLETVRQYALEKLRESGDADAVRARHRDHYAAVAAGLDAPSVAGHERR
Rv2488c|M.tuberculosis_H37Rv YRLLETVRQYALEKLRESGDADAVRARHRDHYAAVAAGLDAPSVAGHERR
MSMEG_3290|M.smegmatis_MC2_155 ----------------LRNDRALAAAAAKAEAGAFESAQDLLAMVEATSL
Mvan_5449|M.vanbaalenii_PYR-1 ----------------NRCDRTIAAASAKAQAGALDVAKDLLKVADAAPM
MAB_3361|M.abscessus_ATCC_1997 ----------------ARGRRALAAAQSKYDAAAFDAARELLGVADMTPL
TH_3225|M.thermoresistible__bu ----------------LRGRRALAAAQAKRDAADSAAAHDLLAIAERAPL
MMAR_0085|M.marinum_M ----------------VRASRALDAAMTSLEAGMPDSATRLVASAAAAAD
Mflv_1156|M.gilvum_PYR-GCK --------------------RRIRAAEHHVVAGDMRRAATLLEQALVDLR
MUL_2555|M.ulcerans_Agy99 ----------------RREQLLASAAFVALQAAQLDEAERLLADAGLGGG
MAV_0578|M.avium_104 ----------------AAGVRAMNLVLLGRGEQAEEALRAITDGADGDAS
MLBr_02341|M.leprae_Br4923 -----------------IGKTRLVAEAVQLAKGLEVEVFSVFCESHATDV
Mb2515c|M.bovis_AF2122/97 LNQAELEIDNLRAAFAFSRENGDTGHALLLASCLQPLWRARGRLQEGLAW
Rv2488c|M.tuberculosis_H37Rv LNQAELEIDNLRAAFAFSRENGDTGHALLLASCLQPLWRARGRLQEGLAW
MSMEG_3290|M.smegmatis_MC2_155 SDLQQAQVDVLRARLAFVTSHG--------SDAPPLLLKAARRLGG----
Mvan_5449|M.vanbaalenii_PYR-1 TELQRAQADLVRAQLAFISNHG--------NDAAPLLLGAARRLES----
MAB_3361|M.abscessus_ATCC_1997 DPLARARATRLRAKIAFAESRVGAFGSVTVSEAAIGLVEAARCLEN----
TH_3225|M.thermoresistible__bu SALEWARAVHLRAQLEFARSRAGDAGGPPVGQTAAALLTAAQLLQD----
MMAR_0085|M.marinum_M DELIAARCELIRAKIAFAASRG--------SDAPPLLLAAAQRMQR----
Mflv_1156|M.gilvum_PYR-GCK PGVLCAIALNLLAGVRMVEDDY---------------IRAVELLER----
MUL_2555|M.ulcerans_Agy99 ASASALLISSFISLYRYG-------------DVTATHRRLVERLQS----
MAV_0578|M.avium_104 DRHYWATVRAANLVWMLGRPAD-----------------AALVLDG----
MLBr_02341|M.leprae_Br4923 AFDVVAQLVRAVAQISGLDDRS----------------ARARVREQIPDA
Mb2515c|M.bovis_AF2122/97 FAAALADHDAHPAGADPGLYARALADRALIDAVAGITDRLDDAQKALAIA
Rv2488c|M.tuberculosis_H37Rv FAAALADHDAHPAGADPGLYARALADRALIDAVAGITDRLDDAQKALAIA
MSMEG_3290|M.smegmatis_MC2_155 -IDPDRARAVYLDAMLAAMFAGRLATGAN---LVEVAAAARSAPERSGA-
Mvan_5449|M.vanbaalenii_PYR-1 -IDPTLARETYLDTLSAAIFAGRLAVDGG---VLEVSEAASAATRSLNT-
MAB_3361|M.abscessus_ATCC_1997 -LDDNLARETYLDAVGAAMYGGRLCPRGG---AVEVAEPARLAPAGAQP-
TH_3225|M.thermoresistible__bu -VDAPAARESYLEAFAALMYAGRLAPSGA---LLEAADAVQAAFARAPEG
MMAR_0085|M.marinum_M -LDPSESRKAYLGAVLASILVGRMATDQHN-SSPSVAKAASNAPAAPHP-
Mflv_1156|M.gilvum_PYR-GCK -ARADADNDAVLVTTLLSLGFCLGMTGSFTAQLATVREAVAVAERAGVP-
MUL_2555|M.ulcerans_Agy99 --ADDLDGETLTRMVNLLLAVSMFAADPA---LWQITDGLVDSLADRLG-
MAV_0578|M.avium_104 ---LAARPETPAQAAARCAVQACLDAVAARCQLAAERARAALDSESLPDF
MLBr_02341|M.leprae_Br4923 DTQDLLLLDDLLGIADPAVELPRLDPDARRRRLTALINVAQLALSRPAVF
Mb2515c|M.bovis_AF2122/97 RDIEDPALLARALTACGGVAAYNADLARPWLAEAVGLARAVGDKWR--LA
Rv2488c|M.tuberculosis_H37Rv RDIEDPALLARALTACGGVAAYNADLARPWLAEAVGLARAVGDKWR--LA
MSMEG_3290|M.smegmatis_MC2_155 AEVSDLLLDWLTAHYGRGYVAARSALGDVLSAFD-GEADDLPLNRM----
Mvan_5449|M.vanbaalenii_PYR-1 PGAADLLLDGMTTQHSAGFEKGLPNVREALRIYGPGMTTEQELRWM----
MAB_3361|M.abscessus_ATCC_1997 ARPSDLLLDGLARRITHGAAASAQTLGEALTLIR-CEAD-RPANTS-WME
TH_3225|M.thermoresistible__bu SRAVDAFCQGMTQRIVGGISAAAAPLRVALTAMC-ELARSRPAEVVHWLV
MMAR_0085|M.marinum_M PRALDVLLDGLVIRLTEGYVAAAPRLRSAIREYLRERDIGVAEP-G----
Mflv_1156|M.gilvum_PYR-GCK ALTSRALAMWVHVSFQAGNGLDSAALLRAVDLEDPEDNTPIPFRAS----
MUL_2555|M.ulcerans_Agy99 ------ELSVIYRDAWADAARRGRTVTQRLKEQLDRLAELEPWDVMR---
MAV_0578|M.avium_104 HAMMASLALIMAMGALGQVDDLTAVAEQALRRATTSFEASHMRFWFG---
MLBr_02341|M.leprae_Br4923 VVEDVHWIDEVSDSMLADFLAVIPQTRSMALVTYRPEYHGALRHVVG---
Mb2515c|M.bovis_AF2122/97 EVLAWQAYVGFAGEGDPGATRAAGEEARSLADEIGDAFLSRSCRWALAAA
Rv2488c|M.tuberculosis_H37Rv EVLAWQAYVGFAGEGDPGATRAAGEEARSLADEIGDAFLSRSCRWALAAA
MSMEG_3290|M.smegmatis_MC2_155 ----LLASTAAHYAWDDVRLDVFTAHHVERARATGALSEVPIALNSRAIA
Mvan_5449|M.vanbaalenii_PYR-1 ----FLACVAAAHVWDLDRLMSLAVRHVQLSRDTGAVSELPLALSCLITP
MAB_3361|M.abscessus_ATCC_1997 QAFPIALESATHEVWDDDMWHHLATRAVHIAREVGALSLLPAALIYRAGM
TH_3225|M.thermoresistible__bu PAFPVLQESAGHELWDENLVDALSEAVVRQARDAGALAGLPQALVYRAGV
MMAR_0085|M.marinum_M --WHDLTARVCLDLFDQDAYNFLAARQVEDLRAAGALTMLPVALVTFAGV
Mflv_1156|M.gilvum_PYR-GCK ----AARGLSLALTGRLAEADGQLAAVAQRSAQRGAEQDVMAVLGYRTLV
MUL_2555|M.ulcerans_Agy99 ------VALAGYYVDLIDDFRSVLVPLADREIEGGAATIALATLALVAAY
MAV_0578|M.avium_104 ----AVYGRACRLTGRIDEFVSTARRLADSARDVPGLAYANLALLLGNAE
MLBr_02341|M.leprae_Br4923 ---AQIIAVAPLSDVETSTLVAELLGLDQSVTQIGELITERAAGNPFFAQ
Mb2515c|M.bovis_AF2122/97 NLWQGNLEAAVGLSREVIGESDAAHDMVSSCAGQACLAHALAHRGDTEAA
Rv2488c|M.tuberculosis_H37Rv NLWQGNLEAAVGLSREVIGESDAAHDMVSSCAGQACLAHALAHRGDTEAA
MSMEG_3290|M.smegmatis_MC2_155 LLFFGDLDGAADAVDEIQAADDATGA-LLAPYAEVGLAAMRGDLARTASL
Mvan_5449|M.vanbaalenii_PYR-1 LLFTGRFGEAARAIDELTAAIDAMGN-NLTPYGALSLAAMSGRRDHLQRL
MAB_3361|M.abscessus_ATCC_1997 HVHAGELDAAAELVQEADAISAATGH-APIRYHSLILAAWRGSEPTAIRL
TH_3225|M.thermoresistible__bu HLLFGEFGLADTLLTEAESITAATDHRGPVRYHRLIIAAWRGDAVEAARL
MMAR_0085|M.marinum_M CVSAGNFGQADALLDESAAIIAATGA-PPRPAIKTYLAAYRGQEQICREG
Mflv_1156|M.gilvum_PYR-GCK AIWRGRYAEADAYAADTMERAEQLGG--SMVIAFSICAAVAAYRGREDQA
MUL_2555|M.ulcerans_Agy99 QLASGQWAEAVDTSQRGVALCSQHHYELFGYQLRGYLGVISACRGDVVRA
MAV_0578|M.avium_104 LARGAAAEAARLVQEALAGAQIHEVTSGLRPASYFALAEAHGRLGHPAQA
MLBr_02341|M.leprae_Br4923 EITRELAERGVLTGER--GRYACSTDVAEVCVPATLQATIAARIDRLSPP
. . .
Mb2515c|M.bovis_AF2122/97 AAAQASIDTAVGLSPV--LSGSACSALVFATL-AAGDVAAAEHARESATR
Rv2488c|M.tuberculosis_H37Rv AAAQASIDTAVGLSPV--LSGSACSALVFATL-AAGDVAAAEHARESATR
MSMEG_3290|M.smegmatis_MC2_155 VDATVAAVTARGEGNG--LTVAWWAEAVLHNG-FGSARKALEAASRAAAF
Mvan_5449|M.vanbaalenii_PYR-1 GSTAIHNAEHRGEGIG--LTVNAWATALLENG-HGRYHAAAEAAVYATSY
MAB_3361|M.abscessus_ATCC_1997 IDEAMRDGAARGEGRL--LGAMGYAAGVLNNS-LGRYELAFMAARRACEH
TH_3225|M.thermoresistible__bu IEAAAADGEARGEGRL--MGLTGYAAALLYNG-IGRYREALAAARTTCEY
MMAR_0085|M.marinum_M VQQTVDSAASRGEGYD--VSVAMYAAAILHNG-LGQYQEAFNAAASGARY
Mflv_1156|M.gilvum_PYR-GCK RDQAAGALAQGGDYVA--LTVWASATLAFLEVSRGNYEQALEAAEPLVDL
MUL_2555|M.ulcerans_Agy99 RELAAQVRVWAEPRRVGFLTGAVAQIAILCSFAEGDYESAYLQATAITAP
MAV_0578|M.avium_104 NEAIAGARSCVPPDFLFMHTGLALATGWALAA-GGQLREAVATAQAAARL
MLBr_02341|M.leprae_Br4923 AKQLLVAAAVIGFRFG---SDLLASLGIDLSVDELIDANLVDQVRFTAPV
.
Mb2515c|M.bovis_AF2122/97 FFGAS----AAAIINDPTSSAQISCARGDLNAAHRLADGAASITRGVHRA
Rv2488c|M.tuberculosis_H37Rv FFGAS----AAAIINDPTSSAQISCARGDLNAAHRLADGAASITRGVHRA
MSMEG_3290|M.smegmatis_MC2_155 PPELA----SANWALIELVEAATRCGAVETAAEAAADLAELTTSSGTDWA
Mvan_5449|M.vanbaalenii_PYR-1 PGDCT----SAGWALIELVEAGSRTGDDAVASAALERLTEMTTPSGTDWG
MAB_3361|M.abscessus_ATCC_1997 -EDLG----LYSWCLIELIEAAVRCGEHDTAVKAFGQLEERALAAQSDWS
TH_3225|M.thermoresistible__bu -EDLG----FYSWCLHELVEAAARVGETDTAHRALGDIEERAGASGTPWG
MMAR_0085|M.marinum_M -DDVG----MCGYLLGELIEAAVRCKEHNAATEALGRLLKRTKASGTPTA
Mflv_1156|M.gilvum_PYR-GCK YRDFPGTELMSACFMPDAIESLIAVGRLDEAEPLIAAFERNGAELDRPWQ
MUL_2555|M.ulcerans_Agy99 -GEFPPLALHATRTLFDLVEAAVHTDRLNEARRHVRAAKRLQFADAPPRL
MAV_0578|M.avium_104 ARDRG---------QPTHELACIQAAAQWGDAAGAVRARALADALSLPLA
MLBr_02341|M.leprae_Br4923 EYAFR----------HPLIRTVAYESQLKSDRARLHRRLAAAIEARAPHS
:
Mb2515c|M.bovis_AF2122/97 RALTTRCRIEIA--QGDRHRAERDAHDALGVAASIGAYLWVPDILECLAS
Rv2488c|M.tuberculosis_H37Rv RALTTRCRIEIA--QGDRHRAERDAHDALGVAASIGAYLWVPDILECLAS
MSMEG_3290|M.smegmatis_MC2_155 LGLAARARALVS--GPA--ESERWYLESIERLENTRARAELARSRLVYGE
Mvan_5449|M.vanbaalenii_PYR-1 LGVEARSRALTT--EGD--AAEALYLEAIERLGRAGMGPDQGRAHLLYGE
MAB_3361|M.abscessus_ATCC_1997 QGMVARSRALIT--VGH--DAEPHYREAIQRLTNTRISAHLARAHLIYGE
TH_3225|M.thermoresistible__bu LGALAGARALLA--DGD--EADRLFREALDHLSRSRVVVHRARVHLTYGE
MMAR_0085|M.marinum_M LGIGASATALVS--DGS--IADAAYREAITHLRRSPVAVHLARTHLTYGE
Mflv_1156|M.gilvum_PYR-GCK LAIGNRCRAMLLSATGDLDGALAAAERAMAEHARLPMPFERARSALTLGE
MUL_2555|M.ulcerans_Agy99 AIATGAAEALCA----SDERAPALFEKVLGHPAVASFPFEHARIRLAYGM
MAV_0578|M.avium_104 DAIACHAEALRAG-NGEALLTVAAAYRAIGDAAAAADAAAQASAAFVEGQ
MLBr_02341|M.leprae_Br4923 VDQHAVLIAEHLEAAGDLHAAYGWHMRAAAWATN-----QDVRAARVSWE
:
Mb2515c|M.bovis_AF2122/97 VMADAGSNREAVRLFGAADAARGRMGAVRFGIYQAGCNSSLATLRKSMGD
Rv2488c|M.tuberculosis_H37Rv VMADAGSNREAVRLFGAADAARGRMGAVRFGIYQAGCNSSLATLRKSMGD
MSMEG_3290|M.smegmatis_MC2_155 WLRRERRRTAARSELRTAHEMFSAMGMSAFAARAQ---------------
Mvan_5449|M.vanbaalenii_PYR-1 WLRRRRRRVDARAQLRSAHHLFDSIGMDAFAERAR---------------
MAB_3361|M.abscessus_ATCC_1997 WLRRCNRRSDARTELTAAHGSFVNMGTAAFAERAE---------------
TH_3225|M.thermoresistible__bu WLRREHRRGEARRELNEAHGMFTRMGAQGFAERSR---------------
MMAR_0085|M.marinum_M WLRRERRRSEARSQLRIAYDMFAQMGAAGFAERAR---------------
Mflv_1156|M.gilvum_PYR-GCK VLRRLRRR-DAAAAVRDALAQFEELGVPLWVARAR---------------
MUL_2555|M.ulcerans_Agy99 RLRRLRRYRNARVVLRAAAEIFAGLGAEPWTQRAR---------------
MAV_0578|M.avium_104 QHQRGRYAAALAGELAEECGGLCTPALR----------------------
MLBr_02341|M.leprae_Br4923 HATKIADALTAEDPHRAAMCIAPRTRLCGIAWRGR---------------
Mb2515c|M.bovis_AF2122/97 SEFDDAWAEGTALSIDEAIAYAQRGRGARKRPTSGWGA-LTPTELEVALL
Rv2488c|M.tuberculosis_H37Rv SEFDDAWAEGTALSIDEAIAYAQRGRGARKRPTSGWGA-LTPTELEVALL
MSMEG_3290|M.smegmatis_MC2_155 ------------------RELAAAGDRIRETVIAAVDHRLTAQEAHIARL
Mvan_5449|M.vanbaalenii_PYR-1 ------------------VELLATGETAQKRTNSRVAA-LTAQEAQIARL
MAB_3361|M.abscessus_ATCC_1997 ------------------RELRATGAKVRKRSASSEKA-LTAQEAQIARM
TH_3225|M.thermoresistible__bu ------------------RELIAVGEKVRRQPLTSGDE-LTAQEAQIAGL
MMAR_0085|M.marinum_M ------------------RELSATGEAVYVQPTGITVD-LTTQESHIARL
Mflv_1156|M.gilvum_PYR-GCK --------------------IALSGLAVSG---SAVGSELTDSERRIAEL
MUL_2555|M.ulcerans_Agy99 ------------------NELRAAGTAVRHSAAVGPAP-LTAQERLVAEL
MAV_0578|M.avium_104 ---------------------------------TPAGLKLSGRQRDVIEL
MLBr_02341|M.leprae_Br4923 -------------------------------------------FNSSSGF
:
Mb2515c|M.bovis_AF2122/97 VGEGLSNKEIGVRLFISPRTVHSHLTHVYTKLGLSSRLQLAQQAARRGES
Rv2488c|M.tuberculosis_H37Rv VGEGLSNKEIGVRLFISPRTVHSHLTHVYTKLGLSSRLQLAQQAARRGES
MSMEG_3290|M.smegmatis_MC2_155 ARDGLSNPEIGARLFISARTVQYHLGKVFTKLGITSRSQLDGVLGHVTDR
Mvan_5449|M.vanbaalenii_PYR-1 ARDGLSNPEIGARLFISARTVQYHLSKVFAKLGIRSRSQLEHSLPELAT-
MAB_3361|M.abscessus_ATCC_1997 AGQGLTNQEIAAQLFISSHTVEWHLRKVFAKRGITSRRQLRSGR------
TH_3225|M.thermoresistible__bu AADGLTNQEIGAQLFLSVHTVEWHLRKVFVKLGITSRRQLRAAPRVTATW
MMAR_0085|M.marinum_M ARDGYTNAEIAGLLFISARTVEWHLSKIFAKLGVTSRRELRAILMESP--
Mflv_1156|M.gilvum_PYR-GCK AASGMSNRDVAETLFVSVKTIETNLSRVYRKLGIRSRAQLGRMLR-----
MUL_2555|M.ulcerans_Agy99 AAKGLSNKEIAARLCLSPRTVGAHLYRLFPKLGVTNRAGLHDALDAIHAA
MAV_0578|M.avium_104 AVAGLSNRQIAERLVMSVRTVEGHIYRACQRVGAQSRDELATIIRSRPAG
MLBr_02341|M.leprae_Br4923 DEVRQLCNATGDKAPLAVATVGPAIDHVYQDRLH----------------
. :: *: : :
Mb2515c|M.bovis_AF2122/97 ERGPSRP
Rv2488c|M.tuberculosis_H37Rv ERGPSRP
MSMEG_3290|M.smegmatis_MC2_155 -------
Mvan_5449|M.vanbaalenii_PYR-1 -------
MAB_3361|M.abscessus_ATCC_1997 -------
TH_3225|M.thermoresistible__bu -------
MMAR_0085|M.marinum_M -------
Mflv_1156|M.gilvum_PYR-GCK -------
MUL_2555|M.ulcerans_Agy99 PDQI---
MAV_0578|M.avium_104 RES----
MLBr_02341|M.leprae_Br4923 -------