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M. bovis AF2122 / 97 Mb2515c (-)

annotation: LuxR family transcriptional regulator
coordinates: 2764268 - 2767681
length: 1137

MDRRPRDFEQSRRRCRCNALRAGSMLASMSKIHPGVDVVPVDWSADGVSELVPTGTVTLLLADIEGATHL
PGSQLDTTAIAKLDRTLTELVREHRGVCPVEQGEGDSFLVAFARASDAVACALGLQRAPLAPIRLRIGMH
TGEVSSPDEGNCVGPTIDRTARLRELAHGGQTVLSGTTSDLVADLLPKDAWLNDLGTYRLDDLPRPERVV
QLCHPDLHNAFPPLRTRKVVGAHCLPAQLTRLVGRVDEVAQVRGLLDVKRWVTLTGVGGVGKTRLATQVA
SAVADGYPDGVWYVNLAPITDPALVPIAAARVLGLPDQPGRSTVDTIVRRIGDRRMLVVLDNCEHLLDGC
AALIVALLGACPALRVLATSREPIAVAGEQIWRVPPLGHGEAIELFTDRAREARPELEITADNLALVTEI
CHRLDGIPLAIELAASRVRALALTEIVDSLHDRFRLLTGGSRIAVRRQQTMRASVDWSHALLTGPEQVLF
RRLAVFPSGFDLDGAQAAAAGGDVQRYEVVDLLSLLADKSLVVTDDSDGRTRYRLLETVRQYALEKLRES
GDADAVRARHRDHYAAVAAGLDAPSVAGHERRLNQAELEIDNLRAAFAFSRENGDTGHALLLASCLQPLW
RARGRLQEGLAWFAAALADHDAHPAGADPGLYARALADRALIDAVAGITDRLDDAQKALAIARDIEDPAL
LARALTACGGVAAYNADLARPWLAEAVGLARAVGDKWRLAEVLAWQAYVGFAGEGDPGATRAAGEEARSL
ADEIGDAFLSRSCRWALAAANLWQGNLEAAVGLSREVIGESDAAHDMVSSCAGQACLAHALAHRGDTEAA
AAAQASIDTAVGLSPVLSGSACSALVFATLAAGDVAAAEHARESATRFFGASAAAIINDPTSSAQISCAR
GDLNAAHRLADGAASITRGVHRARALTTRCRIEIAQGDRHRAERDAHDALGVAASIGAYLWVPDILECLA
SVMADAGSNREAVRLFGAADAARGRMGAVRFGIYQAGCNSSLATLRKSMGDSEFDDAWAEGTALSIDEAI
AYAQRGRGARKRPTSGWGALTPTELEVALLVGEGLSNKEIGVRLFISPRTVHSHLTHVYTKLGLSSRLQL
AQQAARRGESERGPSRP
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2515c--100% (1137)LuxR family transcriptional regulator
M. bovis AF2122 / 97Mb0393-0.056.43% (1088) LuxR/UHPA family transcriptional regulator
M. bovis AF2122 / 97Mb1393-0.052.06% (1093) transcriptional regulatory protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_4504-4e-1225.30% (502) regulatory protein, LuxR
M. tuberculosis H37RvRv2488c-0.0100.00% (1137) LuxR family transcriptional regulator
M. leprae Br4923MLBr_01753-0.050.73% (1092) putative transcriptional regulator
M. abscessus ATCC 19977MAB_3361-8e-1226.05% (453) LuxR family transcriptional regulator
M. marinum MMMAR_0123-0.054.16% (1117) LuxR family transcriptional regulator
M. avium 104MAV_2362-8e-1724.57% (981) TPR repeat-containing protein
M. smegmatis MC2 155MSMEG_0545-5e-2140.70% (172) transcriptional regulator, LuxR family protein
M. thermoresistible (build 8)TH_3225-2e-1326.01% (546) PUTATIVE regulatory protein, LuxR
M. ulcerans Agy99MUL_2743-1e-10942.09% (613) LuxR family transcriptional regulator
M. vanbaalenii PYR-1Mvan_5928-0.072.67% (1083) regulatory protein, LuxR

CLUSTAL 2.0.9 multiple sequence alignment


Mb2515c|M.bovis_AF2122/97           MDRRPRDFEQSRRRCRCNALRAGSMLASMSKIHPGVDVVPVDWSADGVSE
Rv2488c|M.tuberculosis_H37Rv        MDRRPRDFEQSRRRCRCNALRAGSMLASMSKIHPGVDVVPVDWSADGVSE
Mvan_5928|M.vanbaalenii_PYR-1       -----------------------------------------------MSE
MMAR_0123|M.marinum_M               ------------------------MLASMSEIDPRAEAPLVDWSDVDMGE
MLBr_01753|M.leprae_Br4923          ----------------MYSLGEMQKPVPVGADYLASCLVARLRSTDVPTD
MUL_2743|M.ulcerans_Agy99           --------------------------------------------------
MSMEG_0545|M.smegmatis_MC2_155      -----------------------------------------------MTE
MAB_3361|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3225|M.thermoresistible__bu      ---------------------------------------MSSRDGDVVLH
Mflv_4504|M.gilvum_PYR-GCK          ----------------------------------MRAALPAAMMNAMSDA
MAV_2362|M.avium_104                --------------------------------------------------
                                                                                      

Mb2515c|M.bovis_AF2122/97           LVPTGTVTLLLADIEGATHLPGSQLD--TTAIAKLDRTLTELVREHRG--
Rv2488c|M.tuberculosis_H37Rv        LVPTGTVTLLLADIEGATHLPGSQLD--TTAIAKLDRTLTELVREHRG--
Mvan_5928|M.vanbaalenii_PYR-1       LVPTGTVTLLLADVQGSTQLWETQPETMTAAVAQLDRTLTDLVSDHDG--
MMAR_0123|M.marinum_M               LLPTGTVTLLLADVEGSTRLWQNQPEPMTAAVAHLDSVLATTVATHHG--
MLBr_01753|M.leprae_Br4923          LHRGCTVTLFLGDVEGLAELSETQPDEAADAIARLDCVVSEAVAAHGG--
MUL_2743|M.ulcerans_Agy99           ------MTFLFTDVEGSTRLWESDPDRMRAALAAHDAVLTRTIQTHRG--
MSMEG_0545|M.smegmatis_MC2_155      KLSTGTKTLLMARVDRAEELWQTELDQTIAAIPWLRASMAHLIALNDG--
MAB_3361|M.abscessus_ATCC_1997      ------------------------MLRGQAGVGKTALLRYVLGKASGQ--
TH_3225|M.thermoresistible__bu      GRAAEIATLRDVMSTARAGSSRVLVLHGEAGVGKTALLGQLLGDAAGM--
Mflv_4504|M.gilvum_PYR-GCK          SPQAADDPQVAGFLCTATSAPTGLIIEGDAGIGKTTLWLSLLQTARMRGF
MAV_2362|M.avium_104                --MGREAELRRSLAALSNAEFHGVALVGDAGVGKSTLARMLAKTVESA--
                                                                  .:                  

Mb2515c|M.bovis_AF2122/97           VCPVEQGEGDSFLVAFARASDAVACALGLQRAPLAPIRLRIGMHTGEVSS
Rv2488c|M.tuberculosis_H37Rv        VCPVEQGEGDSFLVAFARASDAVACALGLQRAPLAPIRLRIGMHTGEVSS
Mvan_5928|M.vanbaalenii_PYR-1       VRPVEQGEGDSFVVAFTRASDAVACALALQRAPLAPIRLRIGVHTGEVRL
MMAR_0123|M.marinum_M               VRPVEQGEGDSFVVAFASAREAIACALDLQRSPLGPIRLRIGVHTGDIQL
MLBr_01753|M.leprae_Br4923          VQQVVQGVRGNFLATFARASDATACALDLQLAPIVPVRFRIALHTGEVQI
MUL_2743|M.ulcerans_Agy99           WLFKHTGDG--VCAAFASPRSAVDAAVDAQRALELPVR--MGLATGEAEP
MSMEG_0545|M.smegmatis_MC2_155      TLQR--DASDSFVAAFDRASDAVMCALDLQLAPLEPFALCIGVHAVEHTD
MAB_3361|M.abscessus_ATCC_1997      LIAQASGIQSEMELAFAGLQQFCAPLTKYSGAIPDPQREALTIAFGTRSG
TH_3225|M.thermoresistible__bu      RCVQVAGVESDMELAYAGLHQLCAPLLDRLDDLPSPQRDVLNVAFGRGAG
Mflv_4504|M.gilvum_PYR-GCK          QVLTARVGQAESVMAFAALADLLGAVSDEHFAALPPLQRLALDRVLLRAG
MAV_2362|M.avium_104                ------GRTVRFALGTQTGSAVPLGAFSHAVSLMAVNEPAVMLAAAHNTL
                                                                                      

Mb2515c|M.bovis_AF2122/97           PDEG---NCVGPTIDRTARLRELAHGGQTVLSGTTSDLVADLLPKDAWLN
Rv2488c|M.tuberculosis_H37Rv        PDEG---NCVGPTIDRTARLRELAHGGQTVLSGTTSDLVADLLPKDAWLN
Mvan_5928|M.vanbaalenii_PYR-1       RDEG---NYVGPTINRTARLRELAHGGQTVLSGTTSDLVADLLPDGGWLS
MMAR_0123|M.marinum_M               RDPNDPTNYIGPTINRTARIRELAHGGQTVISGATQLLVVDQLPDGAWLA
MLBr_01753|M.leprae_Br4923          SNDD--VNNVVFMMVQAAGLLDLACGGQTVLSSITGDLVVDGLPADTWLV
MUL_2743|M.ulcerans_Agy99           HDAD----YFGAVLNRAARVMATGHGGQILLTDSTANLIS-----GVDLL
MSMEG_0545|M.smegmatis_MC2_155      SADS----------DGAARLRDIARGGQTLISAAAAALVSARMPAHAALT
MAB_3361|M.abscessus_ATCC_1997      PPPD-----RFLIGLAVLSLLAAAAEHQPVLCVIDDAQWLDR----VSLQ
TH_3225|M.thermoresistible__bu      PAPG-----RFLVGLAVLNLLAAAGADQPLLCVIDDAQWLDR----VSLQ
Mflv_4504|M.gilvum_PYR-GCK          ADGP--ATDQRVVAAGFVSLLHILAADAPVLIAIDDVQWLDAS--SRTAI
MAV_2362|M.avium_104                SQDK----NLVVVVDDAQLLDPLSATLVNQLAAWRSARLIVTIRSGEPVL
                                                       :          :                   

Mb2515c|M.bovis_AF2122/97           DLGTYRLDDLPRPERVVQLCHPDLHNAFPPLRTRKVVGAHCLPAQLTRLV
Rv2488c|M.tuberculosis_H37Rv        DLGTYRLDDLPRPERVVQLCHPDLHNAFPPLRTRKVVGAHCLPAQLTRLV
Mvan_5928|M.vanbaalenii_PYR-1       DLGTHRLRDLPRPERVVQLCHADLSNEFPPLRAREEIGVQRLPAQLTSFV
MMAR_0123|M.marinum_M               DLGLHPLRDLPRPERVMQLCHSGLQNDFPPLRTTKSIAVHRMPARLTRFV
MLBr_01753|M.leprae_Br4923          DLGSHLLRDLARPVRVMQLCHRNLRRNLHELGIRTVPGGPSLPVPLTTFV
MUL_2743|M.ulcerans_Agy99           DLGSRRLRDLPAPVRVFQVRAPGLRTDFPALRAPDTSPGN-LRPALTSFV
MSMEG_0545|M.smegmatis_MC2_155      -----PLRDRVRHEPVYQLNHPGLR-------------------------
MAB_3361|M.abscessus_ATCC_1997      TLAFVTRRLGSEPVAMLFAVRDGTDSELAGLPELTVHG-------LRAAD
TH_3225|M.thermoresistible__bu      TLGFVARRLMAEPVAMVFALRDDIHEALVGVPALAVPG-------LADAD
Mflv_4504|M.gilvum_PYR-GCK          EFAVRRLKGAFGVVVTERCVPGDGTTAGWLTLERPDGLIRVSVPPMDAGR
MAV_2362|M.avium_104                DAVTALLKERLLLTVHVDPFTREQTELLAG-------------TVLGGPV
                                                                                      

Mb2515c|M.bovis_AF2122/97           GRVDEVAQVRGLLDVKRWVTLTGVGGVGKTRLATQVASAVADGYPDGVWY
Rv2488c|M.tuberculosis_H37Rv        GRVDEVAQVRGLLDVKRWVTLTGVGGVGKTRLATQVASAVADGYPDGVWY
Mvan_5928|M.vanbaalenii_PYR-1       GRVDDMAQVRGLMDANRLVTLTGAGGVGKTRLATQVAVAVVEGYPGGVWY
MMAR_0123|M.marinum_M               GRIAQMADVRSLLADNRLVTLTGAGGAGKTRLAVEIAASAVDEFGDGLWY
MLBr_01753|M.leprae_Br4923          GRAAQIKELQELLTEKRLLTLVGPGGVGKTRLALQVVARVADEFSGELSY
MUL_2743|M.ulcerans_Agy99           ARAAEIGQVQTALQVHRLVTLTGVGGVGKTRLALEVATRVADEFPDGVWL
MSMEG_0545|M.smegmatis_MC2_155      ---TEADEVP-HLPYGRVVR------------------------------
MAB_3361|M.abscessus_ATCC_1997      AGTLLDSVIPGLLDERVRDRIVAETQGNPLALLELPRDMTAEELAGGFGW
TH_3225|M.thermoresistible__bu      ARTLLEHMFPGAIDANVRDRLVAESRGNPLALLEVPRTYAVGELAGGFVS
Mflv_4504|M.gilvum_PYR-GCK          LHALISHRLGRTLTRPVVLRIAEMSGGNPFYALELAHTHVNSGDSPPAAE
MAV_2362|M.avium_104                DPWVVDELLQRSSGNPLLLRGFLTAGRDTGALFRTAEGWQLRGPLRGDRE
                                            .                                         

Mb2515c|M.bovis_AF2122/97           VNLAPITDPALVPIAAARVLGLPDQPGRSTVDTIVRRIGDRRMLVVLDNC
Rv2488c|M.tuberculosis_H37Rv        VNLAPITDPALVPIAAARVLGLPDQPGRSTVDTIVRRIGDRRMLVVLDNC
Mvan_5928|M.vanbaalenii_PYR-1       VDLAPITDPALVAITVARALGLPDQPGRSTVDTIVRFIADRRMLVVLDNC
MMAR_0123|M.marinum_M               VDLAPVSHAEAVPVTVARALGLSDQPGRSTVDALARFIGEHQVLVVLDNC
MLBr_01753|M.leprae_Br4923          FDLAPDTDHDIFPITVL--------------DNLRRCIGDRRMLMVLDNC
MUL_2743|M.ulcerans_Agy99           FELAAVSDPAAVPDAVAAVLGITQQAGKTVTQSVATALERRVRLLVFDNC
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      PDGGRLAG----------------QIEQTFLRRVQQLPAHTQTLLLAAAT
TH_3225|M.thermoresistible__bu      PGAGSAPS----------------RIEENYVHRIRALPAQTRRLLLIAAA
Mflv_4504|M.gilvum_PYR-GCK          PPLPATLADVVR-----------------RRVGLLDDATRTLLLGVACVA
MAV_2362|M.avium_104                LHDALEYR-------------------LQSLSSEEREVVEILATAGLLNW
                                                                                      

Mb2515c|M.bovis_AF2122/97           EHLLDGCAALIVALLGACPALRVLATSREPIAVAGEQIWRVPPLGHG---
Rv2488c|M.tuberculosis_H37Rv        EHLLDGCAALIVALLGACPALRVLATSREPIAVAGEQIWRVPPLGHG---
Mvan_5928|M.vanbaalenii_PYR-1       EHLLDACATLIDALLGACPALAMLATSREPIAVAGEQTWRVPPLALDD--
MMAR_0123|M.marinum_M               EHLLDATAALLLELTGRCPAVRLLATSREPLGVPGEVTFLVPSLSVT---
MLBr_01753|M.leprae_Br4923          EYLLDVCANVMTTLLGACPSLTILATSREPIGVAGEVIWRVSMLSPAD--
MUL_2743|M.ulcerans_Agy99           EHVRDAAADLIEAILAGSTTVRILATSRERLEVPDEQLWSVPSLDVGGGV
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      DPLGDVTLLARAAQQLGIPMHAIAPAEAADLVELSTRVRFRHPLVRS---
TH_3225|M.thermoresistible__bu      EPIGDSALFLRAAALMGIAVDALAPAEAARVIQFGPRMRFFHPLMRS---
Mflv_4504|M.gilvum_PYR-GCK          DPTVELLARAHGASTDEITAGLERAEAAGIVVLEGNRVRFTHPLLAGG--
MAV_2362|M.avium_104                DILRDICDAEAVAALERRGLIRLVTDGSHAVAQLTHPMLGEAATRHAG--
                                                                                      

Mb2515c|M.bovis_AF2122/97           --EAIELFTDRAREARPELEITAD-NLALVTEICHRLDGIP-LAIELAAS
Rv2488c|M.tuberculosis_H37Rv        --EAIELFTDRAREARPELEITAD-NLALVTEICHRLDGIP-LAIELAAS
Mvan_5928|M.vanbaalenii_PYR-1       --DAIELFTDRARRARPDFIISAD-DAAAVSEICHRLDGMP-LAIELAAA
MMAR_0123|M.marinum_M               --EATELFTDRARRVRPDFAVTDD-NTTAVTEICNRLDCMP-LAIELAAA
MLBr_01753|M.leprae_Br4923          --EAVELFTERAALVQPGFSVTDG-NRQIVTEICQRLDGMP-LAIELAAA
MUL_2743|M.ulcerans_Agy99           VSAAGTLFVERAQSVAPGFAPTDAQDAAAIGEICRRLDGIP-LAIELAAS
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      -AVYISANPLERRRIHGVLAGATDPGADPDRRAWHRAHAAAGTDEAIAWE
TH_3225|M.thermoresistible__bu      -AAYRAADPRDRRAVHRALAEATDPGADPDRRAWHAANGVTGTDDAVAAE
Mflv_4504|M.gilvum_PYR-GCK          --VYTDAGPTARRAMHRAIASVES---HPELRARHLALAASSGDDEIFAA
MAV_2362|M.avium_104                --------MVRTRQLNGKLARALQKHERTGSRHLRLPHLQS--RIRLAEF
                                                                                      

Mb2515c|M.bovis_AF2122/97           RVRALALTEIVDSLHDRFRLLTGGSRIAVRRQQTMRASVDWSHALLTGPE
Rv2488c|M.tuberculosis_H37Rv        RVRALALTEIVDSLHDRFRLLTGGSRIAVRRQQTMRASVDWSHALLTGPE
Mvan_5928|M.vanbaalenii_PYR-1       RVRALSLTEIVDGLHDRFRLLTGGSRTAVRRQQTLRASVDWSHGLLTDPE
MMAR_0123|M.marinum_M               RVRALSIDEIRTGLHDRFRLLTGGARTVVRRQQTLRASVDWSHALLTEPE
MLBr_01753|M.leprae_Br4923          RIRTLSLTEIADGLDDRFRLLTGGARTAVRRQQTLRASMDWSYALLTESE
MUL_2743|M.ulcerans_Agy99           RMASMTPIEVRDRLDHRFRLLVG-SRRGLGRHQTLRHAVAWSYDHLSDAE
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      LEQSAGRAQAKGGVLAAAAFLQRATELTADPAARGRRALAAAQSKYDAAA
TH_3225|M.thermoresistible__bu      LEKSAARAQQRGGIAATATFLERAVVLTADPGLRGRRALAAAQAKRDAAD
Mflv_4504|M.gilvum_PYR-GCK          LDQAADSARARGAPAAAAELMDLALGLGAHDPMRRLKAAENHFLAGDTAK
MAV_2362|M.avium_104                MLHSDMEPDLDVITEAARDALAMSNVQLGEELARFALDRGGGLPAALVLA
                                                                                      

Mb2515c|M.bovis_AF2122/97           QVLFRRLAVFPSGFDLDGAQAAAAGGDVQR-YEVVDLLSLLADKSLVVTD
Rv2488c|M.tuberculosis_H37Rv        QVLFRRLAVFPSGFDLDGAQAAAAGGDVQR-YEVVDLLSLLADKSLVVTD
Mvan_5928|M.vanbaalenii_PYR-1       RVLFRRLAVFAGGFDLDGAQAITVDGEVHR-YEVVDLLTLLVDKSLLIAE
MMAR_0123|M.marinum_M               RVLFRRIAVFLGGFDLDAAQAVAGDSQVQR-YQVVDELALLVDKSLVIAE
MLBr_01753|M.leprae_Br4923          RALFRRLSAISGTFDLKVAYAVGHDDLEEP-DQVFDRLTMLIDKSLVIVE
MUL_2743|M.ulcerans_Agy99           KVLLERCSVFAGGFDLQSACAVAGSADTHDDYEVLDLLDALVGKSLLIVD
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      FDAARELLGVADMTPLDPLARARATRLRAK----IAFAESRVGAFGSVTV
TH_3225|M.thermoresistible__bu      SAAAHDLLAIAERAPLSALEWARAVHLRAQ----LEFARSRAGDAGGPPV
Mflv_4504|M.gilvum_PYR-GCK          AAAALGEVGSIEPPILRAMATSLLATVRMY-----DNEHRQAVDLLRSAL
MAV_2362|M.avium_104                EAVSWQGRGEEAGFVLAHAEPDGDDDWLIARWGCLRAANLFWGCGDAEAA
                                                                                      

Mb2515c|M.bovis_AF2122/97           DSDGRTRYRLLETVRQYALEKLRESGDADAVRARHRDHYAAVAAGLDAPS
Rv2488c|M.tuberculosis_H37Rv        DSDGRTRYRLLETVRQYALEKLRESGDADAVRARHRDHYAAVAAGLDAPS
Mvan_5928|M.vanbaalenii_PYR-1       NTAGRTRYRLLETVRQYAQEKLGESGEADTLRARHRDHYTARAAELDAPS
MMAR_0123|M.marinum_M               SGGGPTRYRLLETVRQYAQEKLAESGEVEAVRSRHVTYYKSVAKLLDAPT
MLBr_01753|M.leprae_Br4923          GRQGGSRYRLLETVRQYAMKKLEESNEVDLVLARHRDHYMALGALLDTPG
MUL_2743|M.ulcerans_Agy99           RLSGRSRFSMLETIREFAEEQLVTRGQALAARTAHARHFAQRLPDVAAVW
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      SEAAIGLVEAARCLENLDDNLARETYLDAVGAAMYGGRLCPRGGAVEVAE
TH_3225|M.thermoresistible__bu      GQTAAALLTAAQLLQDVDAPAARESYLEAFAALMYAGRLAPSGALLEAAD
Mflv_4504|M.gilvum_PYR-GCK          DDAADNVPVQVQVLLRLSFALNSIGELDDAR--RYARDAVKLAEELGFPG
MAV_2362|M.avium_104                RREADTVKKRVSSEAGLHLIDALELSMAFFRGDVETTTELGPGLCESDAV
                                                                                      

Mb2515c|M.bovis_AF2122/97           VAG-HERRLNQAELEIDNLRAAFAFSRENGDTGHALLLASCLQPLWRARG
Rv2488c|M.tuberculosis_H37Rv        VAG-HERRLNQAELEIDNLRAAFAFSRENGDTGHALLLASCLQPLWRARG
Mvan_5928|M.vanbaalenii_PYR-1       VAG-HERRLNQTDIEMDNLRAAFAWSRENANTDHSLLLASSLHPLWRARG
MMAR_0123|M.marinum_M               GTD-HERRLAQAEDELDNLRSAFGWSLETRDFDSALELATSLHPVWMTRG
MLBr_01753|M.leprae_Br4923          DID-HEQLVEQVETELDNLRSAFAWSRETGDIAGALQLASSLQPIWFGRG
MUL_2743|M.ulcerans_Agy99           DSPRQPEAYTWLTAELANLRLAFRWTADNNDLDDAASIATWVGFLGFLVN
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      PARLAPAGAQP-ARPSDLLLDGLARRITHGAAASAQTLGEALTLIRCEAD
TH_3225|M.thermoresistible__bu      AVQAAFARAPEGSRAVDAFCQGMTQRIVGGISAAAAPLRVALTAMCELAR
Mflv_4504|M.gilvum_PYR-GCK          ATSAALAWAVHVDFQCGRGLDETALARAMKLYDSTFDVPIIFR-------
MAV_2362|M.avium_104                PMATTWAAVPTCAALAATGRYSEVGRIADIGVRAAMSCGMGLHRFN----
                                                                                      

Mb2515c|M.bovis_AF2122/97           RLQEGLAWFAAALADHDAHPAGA---------DPGLYARALADRALIDAV
Rv2488c|M.tuberculosis_H37Rv        RLQEGLAWFAAALADHDAHPAGA---------DPGLYARALADRALIDAV
Mvan_5928|M.vanbaalenii_PYR-1       RLQEGQAWFDAALTDYEARPGEA---------DPAVYARALADRAFMDGH
MMAR_0123|M.marinum_M               QGREGLAWLEAGLGNEAGLGNEAGLGNEDVQVSPSTLARALADKVTLLAW
MLBr_01753|M.leprae_Br4923          HMYEGLAWFDSIFEHKNIEHLVA---------PKEVLARAVANKVMLHAI
MUL_2743|M.ulcerans_Agy99           R-FEPLTWVEEAIER-----------------------------------
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      -RPANTS-------------------------------------------
TH_3225|M.thermoresistible__bu      SRPAEVVH------------------------------------------
Mflv_4504|M.gilvum_PYR-GCK          --------------------------------------------------
MAV_2362|M.avium_104                --------------------------------------------------
                                                                                      

Mb2515c|M.bovis_AF2122/97           AG-----ITDRLDDAQKALAIARDIEDPALLARALTACGGVAAYNADLAR
Rv2488c|M.tuberculosis_H37Rv        AG-----ITDRLDDAQKALAIARDIEDPALLARALTACGGVAAYNADLAR
Mvan_5928|M.vanbaalenii_PYR-1       VG-----ITDRLDQAQKALAMARDIDDPALLVRALTACGGLAAYNADVAR
MMAR_0123|M.marinum_M               TG-----SMAGFDDAERALTIARELADPALLIRALVARGVITAYDADVAR
MLBr_01753|M.leprae_Br4923          LASSPPDGSDLVTQAQQALTMAREIGDSAVLARALTACGFSSGYDTEVAR
MUL_2743|M.ulcerans_Agy99           -----------------------AVDHPKLAFLHVLASQCYTTGRVQEAI
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      --------------------------WMEQAFPIALESATHEVWDDDMWH
TH_3225|M.thermoresistible__bu      --------------------------WLVPAFPVLQESAGHELWDENLVD
Mflv_4504|M.gilvum_PYR-GCK          -------------------------------APFVHALAMSWTGRLEQAH
MAV_2362|M.avium_104                -------------------------------IGISEIIAATDAGDDRAAE
                                                                                      

Mb2515c|M.bovis_AF2122/97           PWLAEAVGLARAVGDKWRLAEVLAWQAYVGFAGEGDPGATRAAGEEARSL
Rv2488c|M.tuberculosis_H37Rv        PWLAEAVGLARAVGDKWRLAEVLAWQAYVGFAGEGDPGATRAAGEEARSL
Mvan_5928|M.vanbaalenii_PYR-1       PLLAEAVDLARSMGDKWMLAETLAWQAYAALMGGGDPVAARTAGEEAREL
MMAR_0123|M.marinum_M               PYFDEAAQLARELGDSWRLSQILSLQTRAAMAAG-DPIALEAAGEEGLRI
MLBr_01753|M.leprae_Br4923          PYFAEAVELARTQGDKWTLSQIRLWG-VVGFCVSGDPVALRAAAEAADDL
MUL_2743|M.ulcerans_Agy99           RYADEAARLLAT--DRYEVPFGIEGWPSGACTSSGHPEQSVELCRTQLAL
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      HLATRAVHIAREVGALSLLPAALIYRAGMHVHAGELDAAAELVQEADAIS
TH_3225|M.thermoresistible__bu      ALSEAVVRQARDAGALAGLPQALVYRAGVHLLFGEFGLADTLLTEAESIT
Mflv_4504|M.gilvum_PYR-GCK          QELTAVRGVCLERGAESDMMAIAGFLAINHLWRGQITDAEAEAAEAVERA
MAV_2362|M.avium_104                RIYKRYAAMAEGLPGAEAMVD--AMLGVVRLARGEFPAACAAFTRSISLF
                                                                                      

Mb2515c|M.bovis_AF2122/97           ADEIGDAFLSRSCRWALAAANLWQGNLEAAVGLSREVIGESDAAHDMVSS
Rv2488c|M.tuberculosis_H37Rv        ADEIGDAFLSRSCRWALAAANLWQGNLEAAVGLSREVIGESDAAHDMVSS
Mvan_5928|M.vanbaalenii_PYR-1       ADEMGDGFVSRICGWLLGIAHHFQGDLDAALALADGVVSESDVAHDTLNG
MMAR_0123|M.marinum_M               AEAIGDRTTSRECRGALGWVRAWRGDPIGALHQLGEAIAEASAAHDLLLL
MLBr_01753|M.leprae_Br4923          AQEIGDRFVSLQCRLLLSIAQLWQGDMDGAIVRSGEVVAGAEAAHDTVTR
MUL_2743|M.ulcerans_Agy99           GHDTHTLTLG-----CLVLALTIKGQCDEAEQLADALIESAEATRNPAAL
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      AATGH-----APIRYHSLILAAWRGSEPTAIRLIDEAMRDGAARGEGRLL
TH_3225|M.thermoresistible__bu      AATDHR----GPVRYHRLIIAAWRGDAVEAARLIEAAAADGEARGEGRLM
Mflv_4504|M.gilvum_PYR-GCK          EQLGGDDVLIIPMT-VRGAIAAYAGRVDDARADARWVLAAVRNRKASHIA
MAV_2362|M.avium_104                AKGFPSP--------WLVVVGAFQAQAEGARGDSTAAAAALWRADRAYGP
                                                                                      

Mb2515c|M.bovis_AF2122/97           CAGQACLAHALAHRGDTEAA-AAAQASIDTAVGLSPVLSGSACSALVFAT
Rv2488c|M.tuberculosis_H37Rv        CAGQACLAHALAHRGDTEAA-AAAQASIDTAVGLSPVLSGSACSALVFAT
Mvan_5928|M.vanbaalenii_PYR-1       CCGELVLAHSLAQRGDTDAARAAAQVSLNVAVEVSPVHAGLAHAALAVAN
MMAR_0123|M.marinum_M               MISQVVQGFTYAYVGDADGACACADAVFTSSAELVGANEGLGYATAAIAC
MLBr_01753|M.leprae_Br4923          TFGLYVQTRALVHR-DVSAALVTAGLVVEAAAELSGVYQGIGYAAMVFAA
MUL_2743|M.ulcerans_Agy99           CYALLAYGFTFRDTNPASALAAMRRG------------------------
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      GAMGYAAGVLNNSLGRYELAFMAARR------------------------
TH_3225|M.thermoresistible__bu      GLTGYAAALLYNGIGRYREALAAART------------------------
Mflv_4504|M.gilvum_PYR-GCK          DWPGMTLCFLEESLGNHREALAALDDS-----------------------
MAV_2362|M.avium_104                HAAVFLPELELARAWERAAA------------------------------
                                                                                      

Mb2515c|M.bovis_AF2122/97           LAAGDVAAAEHARESATRFFGASAAAIINDPTSSAQISCARGDLNAAHRL
Rv2488c|M.tuberculosis_H37Rv        LAAGDVAAAEHARESATRFFGASAAAIINDPTSSAQISCARGDLNAAHRL
Mvan_5928|M.vanbaalenii_PYR-1       LAAGDVTAAEAASDSATRSFGPSEVAGIQDPNVAAQIACTRGDLDTARSL
MMAR_0123|M.marinum_M               QAAGDATAAWKAYQKARELVGMDPQMAGVFP-FGALAPLVSGDLSAARRW
MLBr_01753|M.leprae_Br4923          LAMGDVAAAVEASEACRPHLGADHGLVAIHLELMAAVALARGDVIVARRL
MUL_2743|M.ulcerans_Agy99           -----------------------------------------------LRI
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      --------------------------------------------------
TH_3225|M.thermoresistible__bu      --------------------------------------------------
Mflv_4504|M.gilvum_PYR-GCK          -----------------------------------------------FIA
MAV_2362|M.avium_104                --------------------------------------------------
                                                                                      

Mb2515c|M.bovis_AF2122/97           ADGAASITRGVHRARALTTRCRIEIAQGDRHRAERDAHDALGVAASIGAY
Rv2488c|M.tuberculosis_H37Rv        ADGAASITRGVHRARALTTRCRIEIAQGDRHRAERDAHDALGVAASIGAY
Mvan_5928|M.vanbaalenii_PYR-1       VDGAVSITRGVHRASALTTRARIAIAQGDPEQAERNAHDALSLAAGVGAR
MMAR_0123|M.marinum_M               ADDVVSTSYGCYLSVALTARARVALAQGELGQADRDSHAALSCSAANGTT
MLBr_01753|M.leprae_Br4923          ADNSVSATTGWHQMAALTTRARIAMAQGEPELARADIHAALACGADIQAS
MUL_2743|M.ulcerans_Agy99           AQDTGNRNSETHLAAVLCR---VEAKYGDPLSALDHFTLAIHNHHEAGNT
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      ACEHEDLGLYSWCLIELIEAAVRCGEHDTAVKAFGQLEERALAAQSDWSQ
TH_3225|M.thermoresistible__bu      TCEYEDLGFYSWCLHELVEAAARVGETDTAHRALGDIEERAGASGTPWGL
Mflv_4504|M.gilvum_PYR-GCK          AGPPTTELMYAWHLPDAIEAMVGVGRLDDAEILTAALERNGVEHDRRWMR
MAV_2362|M.avium_104                -GDTQAATTHATQAAEIARAAGMHAAEMRTRHAAVRFGDRSQTARLERLA
                                                                                      

Mb2515c|M.bovis_AF2122/97           LWVPDILECLASVM----ADAGSNREAVRLFGAADAARGRMGAVRFGIYQ
Rv2488c|M.tuberculosis_H37Rv        LWVPDILECLASVM----ADAGSNREAVRLFGAADAARGRMGAVRFGIYQ
Mvan_5928|M.vanbaalenii_PYR-1       LEVPDTLECLARVV----GDGGSHHEAARLCGAAEAIRGRTGAVRFRIYD
MMAR_0123|M.marinum_M               LGVADTLECLAELA----ATEGDRREAARLLASAEAIRHRTGEVRLKILD
MLBr_01753|M.leprae_Br4923          LGISDSMELLAELI----SQGDNHRQAGRLFGAASAQREKTGEVRFKVWD
MUL_2743|M.ulcerans_Agy99           TLISTPLAVLAAFF----DRLGRYEAAATIAGFAFHPITEASFP------
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      GMVARSRALITVGH----DAEPHYREAIQRLTNTRISAHLARAHLIYGEW
TH_3225|M.thermoresistible__bu      GALAGARALLADGD----EADRLFREALDHLSRSRVVVHRARVHLTYGEW
Mflv_4504|M.gilvum_PYR-GCK          AVGARCRAMLLAAHGDVAAAEQMAHRAISEHDHLPMPFERARTRLLLGQL
MAV_2362|M.avium_104                RILDTPLAEAAADH-----ARGLTQRDGDLLDAAAQQFADLGALACAADA
                                                                                      

Mb2515c|M.bovis_AF2122/97           AGCNSSLATLRKSMGDSEFDDAWAEGTALSIDEAIAYAQRGRGARKRPTS
Rv2488c|M.tuberculosis_H37Rv        AGCNSSLATLRKSMGDSEFDDAWAEGTALSIDEAIAYAQRGRGARKRPTS
Mvan_5928|M.vanbaalenii_PYR-1       ADHETTVTTLRDALGDKAFEAAWTEGSATSITEAIAYAQRGRGERKRPSS
MMAR_0123|M.marinum_M               AHCEVVLAELRNELGEQDFAAVWGQGAVISTDEVISYVRRGRGTRRRPSS
MLBr_01753|M.leprae_Br4923          AGYESAVAVLRGAMGCKDFDSAWAEGAAMPIDDAITYAQRGRGNRKRPTT
MUL_2743|M.ulcerans_Agy99           -ELRTTISHLRDALGDHAYESFSQSGAAMTTAAMATYAYHQIDHARTEFQ
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      LRRCNRRSDARTELTAAHGSFVNMGTAAFAERAERELRATGAKVRKRSAS
TH_3225|M.thermoresistible__bu      LRREHRRGEARRELNEAHGMFTRMGAQGFAERSRRELIAVGEKVRRQPLT
Mflv_4504|M.gilvum_PYR-GCK          QRRLRQKATAAKNLTDALHTFEQLGTPLWAQRARSELAR-------AVVA
MAV_2362|M.avium_104                AAQAAGEHARRGDRGKKFESSAWAH--ALASRYELHTPAVEAAARPLPFS
                                                                                      

Mb2515c|M.bovis_AF2122/97           GWGALTPTELEVALLVGEGLSNKEIGVRLFISPRTVHSHLTHVYTKLGLS
Rv2488c|M.tuberculosis_H37Rv        GWGALTPTELEVALLVGEGLSNKEIGVRLFISPRTVHSHLTHVYTKLGLS
Mvan_5928|M.vanbaalenii_PYR-1       GWASLTPTELDVVGLVSEGLSNKDIAARLFVSPRTVQTHLTHVYTKLCLA
MMAR_0123|M.marinum_M               GWGSLTPTEHDVVRLVQEGLSNKDIAARMFISPRTVQTHLTHVYTKLGLT
MLBr_01753|M.leprae_Br4923          GWESLTPAEHNVIRLVSEGLDTKDIAARLFVSVRTVHTHLTRIYSKLGLT
MUL_2743|M.ulcerans_Agy99           AR------------------------------------------------
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------------------
MAB_3361|M.abscessus_ATCC_1997      SEKALTAQEAQIARMAGQGLTNQEIAAQLFISSHTVEWHLRKVFAKRGIT
TH_3225|M.thermoresistible__bu      SGDELTAQEAQIAGLAADGLTNQEIGAQLFLSVHTVEWHLRKVFVKLGIT
Mflv_4504|M.gilvum_PYR-GCK          PAEGLTPSEQKVAEMAAAGATNKDIAAAMFISSKTVEHNLTRIYRKLGIS
MAV_2362|M.avium_104                G------RERQIVNLVAAGLSNREIADRLVISVRTVEGHLYRLFTKLGIN
                                                                                      

Mb2515c|M.bovis_AF2122/97           SRLQLAQQAARRGESERGPSRP----------------
Rv2488c|M.tuberculosis_H37Rv        SRLQLAQQAARRGESERGPSRP----------------
Mvan_5928|M.vanbaalenii_PYR-1       SRVQLAQEAARHT-------------------------
MMAR_0123|M.marinum_M               SRIQLVHEVARHA-------------------------
MLBr_01753|M.leprae_Br4923          SRVQLVQEAARHN-------------------------
MUL_2743|M.ulcerans_Agy99           --------------------------------------
MSMEG_0545|M.smegmatis_MC2_155      --------------------------------------
MAB_3361|M.abscessus_ATCC_1997      SRRQLRSGR-----------------------------
TH_3225|M.thermoresistible__bu      SRRQLRAAPRVTATW-----------------------
Mflv_4504|M.gilvum_PYR-GCK          SRAELGRRMDQPGL------------------------
MAV_2362|M.avium_104                SREQLTLLVAREPRGRRELLGHSNPSLGDQDDVHPHAG