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MDRRPRDFEQSRRRCRCNALRAGSMLASMSKIHPGVDVVPVDWSADGVSELVPTGTVTLLLADIEGATHL PGSQLDTTAIAKLDRTLTELVREHRGVCPVEQGEGDSFLVAFARASDAVACALGLQRAPLAPIRLRIGMH TGEVSSPDEGNCVGPTIDRTARLRELAHGGQTVLSGTTSDLVADLLPKDAWLNDLGTYRLDDLPRPERVV QLCHPDLHNAFPPLRTRKVVGAHCLPAQLTRLVGRVDEVAQVRGLLDVKRWVTLTGVGGVGKTRLATQVA SAVADGYPDGVWYVNLAPITDPALVPIAAARVLGLPDQPGRSTVDTIVRRIGDRRMLVVLDNCEHLLDGC AALIVALLGACPALRVLATSREPIAVAGEQIWRVPPLGHGEAIELFTDRAREARPELEITADNLALVTEI CHRLDGIPLAIELAASRVRALALTEIVDSLHDRFRLLTGGSRIAVRRQQTMRASVDWSHALLTGPEQVLF RRLAVFPSGFDLDGAQAAAAGGDVQRYEVVDLLSLLADKSLVVTDDSDGRTRYRLLETVRQYALEKLRES GDADAVRARHRDHYAAVAAGLDAPSVAGHERRLNQAELEIDNLRAAFAFSRENGDTGHALLLASCLQPLW RARGRLQEGLAWFAAALADHDAHPAGADPGLYARALADRALIDAVAGITDRLDDAQKALAIARDIEDPAL LARALTACGGVAAYNADLARPWLAEAVGLARAVGDKWRLAEVLAWQAYVGFAGEGDPGATRAAGEEARSL ADEIGDAFLSRSCRWALAAANLWQGNLEAAVGLSREVIGESDAAHDMVSSCAGQACLAHALAHRGDTEAA AAAQASIDTAVGLSPVLSGSACSALVFATLAAGDVAAAEHARESATRFFGASAAAIINDPTSSAQISCAR GDLNAAHRLADGAASITRGVHRARALTTRCRIEIAQGDRHRAERDAHDALGVAASIGAYLWVPDILECLA SVMADAGSNREAVRLFGAADAARGRMGAVRFGIYQAGCNSSLATLRKSMGDSEFDDAWAEGTALSIDEAI AYAQRGRGARKRPTSGWGALTPTELEVALLVGEGLSNKEIGVRLFISPRTVHSHLTHVYTKLGLSSRLQL AQQAARRGESERGPSRP
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2515c | - | - | 100% (1137) | LuxR family transcriptional regulator |
M. bovis AF2122 / 97 | Mb0393 | - | 0.0 | 56.43% (1088) | LuxR/UHPA family transcriptional regulator |
M. bovis AF2122 / 97 | Mb1393 | - | 0.0 | 52.06% (1093) | transcriptional regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_4504 | - | 4e-12 | 25.30% (502) | regulatory protein, LuxR |
M. tuberculosis H37Rv | Rv2488c | - | 0.0 | 100.00% (1137) | LuxR family transcriptional regulator |
M. leprae Br4923 | MLBr_01753 | - | 0.0 | 50.73% (1092) | putative transcriptional regulator |
M. abscessus ATCC 19977 | MAB_3361 | - | 8e-12 | 26.05% (453) | LuxR family transcriptional regulator |
M. marinum M | MMAR_0123 | - | 0.0 | 54.16% (1117) | LuxR family transcriptional regulator |
M. avium 104 | MAV_2362 | - | 8e-17 | 24.57% (981) | TPR repeat-containing protein |
M. smegmatis MC2 155 | MSMEG_0545 | - | 5e-21 | 40.70% (172) | transcriptional regulator, LuxR family protein |
M. thermoresistible (build 8) | TH_3225 | - | 2e-13 | 26.01% (546) | PUTATIVE regulatory protein, LuxR |
M. ulcerans Agy99 | MUL_2743 | - | 1e-109 | 42.09% (613) | LuxR family transcriptional regulator |
M. vanbaalenii PYR-1 | Mvan_5928 | - | 0.0 | 72.67% (1083) | regulatory protein, LuxR |
CLUSTAL 2.0.9 multiple sequence alignment Mb2515c|M.bovis_AF2122/97 MDRRPRDFEQSRRRCRCNALRAGSMLASMSKIHPGVDVVPVDWSADGVSE Rv2488c|M.tuberculosis_H37Rv MDRRPRDFEQSRRRCRCNALRAGSMLASMSKIHPGVDVVPVDWSADGVSE Mvan_5928|M.vanbaalenii_PYR-1 -----------------------------------------------MSE MMAR_0123|M.marinum_M ------------------------MLASMSEIDPRAEAPLVDWSDVDMGE MLBr_01753|M.leprae_Br4923 ----------------MYSLGEMQKPVPVGADYLASCLVARLRSTDVPTD MUL_2743|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_0545|M.smegmatis_MC2_155 -----------------------------------------------MTE MAB_3361|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3225|M.thermoresistible__bu ---------------------------------------MSSRDGDVVLH Mflv_4504|M.gilvum_PYR-GCK ----------------------------------MRAALPAAMMNAMSDA MAV_2362|M.avium_104 -------------------------------------------------- Mb2515c|M.bovis_AF2122/97 LVPTGTVTLLLADIEGATHLPGSQLD--TTAIAKLDRTLTELVREHRG-- Rv2488c|M.tuberculosis_H37Rv LVPTGTVTLLLADIEGATHLPGSQLD--TTAIAKLDRTLTELVREHRG-- Mvan_5928|M.vanbaalenii_PYR-1 LVPTGTVTLLLADVQGSTQLWETQPETMTAAVAQLDRTLTDLVSDHDG-- MMAR_0123|M.marinum_M LLPTGTVTLLLADVEGSTRLWQNQPEPMTAAVAHLDSVLATTVATHHG-- MLBr_01753|M.leprae_Br4923 LHRGCTVTLFLGDVEGLAELSETQPDEAADAIARLDCVVSEAVAAHGG-- MUL_2743|M.ulcerans_Agy99 ------MTFLFTDVEGSTRLWESDPDRMRAALAAHDAVLTRTIQTHRG-- MSMEG_0545|M.smegmatis_MC2_155 KLSTGTKTLLMARVDRAEELWQTELDQTIAAIPWLRASMAHLIALNDG-- MAB_3361|M.abscessus_ATCC_1997 ------------------------MLRGQAGVGKTALLRYVLGKASGQ-- TH_3225|M.thermoresistible__bu GRAAEIATLRDVMSTARAGSSRVLVLHGEAGVGKTALLGQLLGDAAGM-- Mflv_4504|M.gilvum_PYR-GCK SPQAADDPQVAGFLCTATSAPTGLIIEGDAGIGKTTLWLSLLQTARMRGF MAV_2362|M.avium_104 --MGREAELRRSLAALSNAEFHGVALVGDAGVGKSTLARMLAKTVESA-- .: Mb2515c|M.bovis_AF2122/97 VCPVEQGEGDSFLVAFARASDAVACALGLQRAPLAPIRLRIGMHTGEVSS Rv2488c|M.tuberculosis_H37Rv VCPVEQGEGDSFLVAFARASDAVACALGLQRAPLAPIRLRIGMHTGEVSS Mvan_5928|M.vanbaalenii_PYR-1 VRPVEQGEGDSFVVAFTRASDAVACALALQRAPLAPIRLRIGVHTGEVRL MMAR_0123|M.marinum_M VRPVEQGEGDSFVVAFASAREAIACALDLQRSPLGPIRLRIGVHTGDIQL MLBr_01753|M.leprae_Br4923 VQQVVQGVRGNFLATFARASDATACALDLQLAPIVPVRFRIALHTGEVQI MUL_2743|M.ulcerans_Agy99 WLFKHTGDG--VCAAFASPRSAVDAAVDAQRALELPVR--MGLATGEAEP MSMEG_0545|M.smegmatis_MC2_155 TLQR--DASDSFVAAFDRASDAVMCALDLQLAPLEPFALCIGVHAVEHTD MAB_3361|M.abscessus_ATCC_1997 LIAQASGIQSEMELAFAGLQQFCAPLTKYSGAIPDPQREALTIAFGTRSG TH_3225|M.thermoresistible__bu RCVQVAGVESDMELAYAGLHQLCAPLLDRLDDLPSPQRDVLNVAFGRGAG Mflv_4504|M.gilvum_PYR-GCK QVLTARVGQAESVMAFAALADLLGAVSDEHFAALPPLQRLALDRVLLRAG MAV_2362|M.avium_104 ------GRTVRFALGTQTGSAVPLGAFSHAVSLMAVNEPAVMLAAAHNTL Mb2515c|M.bovis_AF2122/97 PDEG---NCVGPTIDRTARLRELAHGGQTVLSGTTSDLVADLLPKDAWLN Rv2488c|M.tuberculosis_H37Rv PDEG---NCVGPTIDRTARLRELAHGGQTVLSGTTSDLVADLLPKDAWLN Mvan_5928|M.vanbaalenii_PYR-1 RDEG---NYVGPTINRTARLRELAHGGQTVLSGTTSDLVADLLPDGGWLS MMAR_0123|M.marinum_M RDPNDPTNYIGPTINRTARIRELAHGGQTVISGATQLLVVDQLPDGAWLA MLBr_01753|M.leprae_Br4923 SNDD--VNNVVFMMVQAAGLLDLACGGQTVLSSITGDLVVDGLPADTWLV MUL_2743|M.ulcerans_Agy99 HDAD----YFGAVLNRAARVMATGHGGQILLTDSTANLIS-----GVDLL MSMEG_0545|M.smegmatis_MC2_155 SADS----------DGAARLRDIARGGQTLISAAAAALVSARMPAHAALT MAB_3361|M.abscessus_ATCC_1997 PPPD-----RFLIGLAVLSLLAAAAEHQPVLCVIDDAQWLDR----VSLQ TH_3225|M.thermoresistible__bu PAPG-----RFLVGLAVLNLLAAAGADQPLLCVIDDAQWLDR----VSLQ Mflv_4504|M.gilvum_PYR-GCK ADGP--ATDQRVVAAGFVSLLHILAADAPVLIAIDDVQWLDAS--SRTAI MAV_2362|M.avium_104 SQDK----NLVVVVDDAQLLDPLSATLVNQLAAWRSARLIVTIRSGEPVL : : Mb2515c|M.bovis_AF2122/97 DLGTYRLDDLPRPERVVQLCHPDLHNAFPPLRTRKVVGAHCLPAQLTRLV Rv2488c|M.tuberculosis_H37Rv DLGTYRLDDLPRPERVVQLCHPDLHNAFPPLRTRKVVGAHCLPAQLTRLV Mvan_5928|M.vanbaalenii_PYR-1 DLGTHRLRDLPRPERVVQLCHADLSNEFPPLRAREEIGVQRLPAQLTSFV MMAR_0123|M.marinum_M DLGLHPLRDLPRPERVMQLCHSGLQNDFPPLRTTKSIAVHRMPARLTRFV MLBr_01753|M.leprae_Br4923 DLGSHLLRDLARPVRVMQLCHRNLRRNLHELGIRTVPGGPSLPVPLTTFV MUL_2743|M.ulcerans_Agy99 DLGSRRLRDLPAPVRVFQVRAPGLRTDFPALRAPDTSPGN-LRPALTSFV MSMEG_0545|M.smegmatis_MC2_155 -----PLRDRVRHEPVYQLNHPGLR------------------------- MAB_3361|M.abscessus_ATCC_1997 TLAFVTRRLGSEPVAMLFAVRDGTDSELAGLPELTVHG-------LRAAD TH_3225|M.thermoresistible__bu TLGFVARRLMAEPVAMVFALRDDIHEALVGVPALAVPG-------LADAD Mflv_4504|M.gilvum_PYR-GCK EFAVRRLKGAFGVVVTERCVPGDGTTAGWLTLERPDGLIRVSVPPMDAGR MAV_2362|M.avium_104 DAVTALLKERLLLTVHVDPFTREQTELLAG-------------TVLGGPV Mb2515c|M.bovis_AF2122/97 GRVDEVAQVRGLLDVKRWVTLTGVGGVGKTRLATQVASAVADGYPDGVWY Rv2488c|M.tuberculosis_H37Rv GRVDEVAQVRGLLDVKRWVTLTGVGGVGKTRLATQVASAVADGYPDGVWY Mvan_5928|M.vanbaalenii_PYR-1 GRVDDMAQVRGLMDANRLVTLTGAGGVGKTRLATQVAVAVVEGYPGGVWY MMAR_0123|M.marinum_M GRIAQMADVRSLLADNRLVTLTGAGGAGKTRLAVEIAASAVDEFGDGLWY MLBr_01753|M.leprae_Br4923 GRAAQIKELQELLTEKRLLTLVGPGGVGKTRLALQVVARVADEFSGELSY MUL_2743|M.ulcerans_Agy99 ARAAEIGQVQTALQVHRLVTLTGVGGVGKTRLALEVATRVADEFPDGVWL MSMEG_0545|M.smegmatis_MC2_155 ---TEADEVP-HLPYGRVVR------------------------------ MAB_3361|M.abscessus_ATCC_1997 AGTLLDSVIPGLLDERVRDRIVAETQGNPLALLELPRDMTAEELAGGFGW TH_3225|M.thermoresistible__bu ARTLLEHMFPGAIDANVRDRLVAESRGNPLALLEVPRTYAVGELAGGFVS Mflv_4504|M.gilvum_PYR-GCK LHALISHRLGRTLTRPVVLRIAEMSGGNPFYALELAHTHVNSGDSPPAAE MAV_2362|M.avium_104 DPWVVDELLQRSSGNPLLLRGFLTAGRDTGALFRTAEGWQLRGPLRGDRE . Mb2515c|M.bovis_AF2122/97 VNLAPITDPALVPIAAARVLGLPDQPGRSTVDTIVRRIGDRRMLVVLDNC Rv2488c|M.tuberculosis_H37Rv VNLAPITDPALVPIAAARVLGLPDQPGRSTVDTIVRRIGDRRMLVVLDNC Mvan_5928|M.vanbaalenii_PYR-1 VDLAPITDPALVAITVARALGLPDQPGRSTVDTIVRFIADRRMLVVLDNC MMAR_0123|M.marinum_M VDLAPVSHAEAVPVTVARALGLSDQPGRSTVDALARFIGEHQVLVVLDNC MLBr_01753|M.leprae_Br4923 FDLAPDTDHDIFPITVL--------------DNLRRCIGDRRMLMVLDNC MUL_2743|M.ulcerans_Agy99 FELAAVSDPAAVPDAVAAVLGITQQAGKTVTQSVATALERRVRLLVFDNC MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 PDGGRLAG----------------QIEQTFLRRVQQLPAHTQTLLLAAAT TH_3225|M.thermoresistible__bu PGAGSAPS----------------RIEENYVHRIRALPAQTRRLLLIAAA Mflv_4504|M.gilvum_PYR-GCK PPLPATLADVVR-----------------RRVGLLDDATRTLLLGVACVA MAV_2362|M.avium_104 LHDALEYR-------------------LQSLSSEEREVVEILATAGLLNW Mb2515c|M.bovis_AF2122/97 EHLLDGCAALIVALLGACPALRVLATSREPIAVAGEQIWRVPPLGHG--- Rv2488c|M.tuberculosis_H37Rv EHLLDGCAALIVALLGACPALRVLATSREPIAVAGEQIWRVPPLGHG--- Mvan_5928|M.vanbaalenii_PYR-1 EHLLDACATLIDALLGACPALAMLATSREPIAVAGEQTWRVPPLALDD-- MMAR_0123|M.marinum_M EHLLDATAALLLELTGRCPAVRLLATSREPLGVPGEVTFLVPSLSVT--- MLBr_01753|M.leprae_Br4923 EYLLDVCANVMTTLLGACPSLTILATSREPIGVAGEVIWRVSMLSPAD-- MUL_2743|M.ulcerans_Agy99 EHVRDAAADLIEAILAGSTTVRILATSRERLEVPDEQLWSVPSLDVGGGV MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 DPLGDVTLLARAAQQLGIPMHAIAPAEAADLVELSTRVRFRHPLVRS--- TH_3225|M.thermoresistible__bu EPIGDSALFLRAAALMGIAVDALAPAEAARVIQFGPRMRFFHPLMRS--- Mflv_4504|M.gilvum_PYR-GCK DPTVELLARAHGASTDEITAGLERAEAAGIVVLEGNRVRFTHPLLAGG-- MAV_2362|M.avium_104 DILRDICDAEAVAALERRGLIRLVTDGSHAVAQLTHPMLGEAATRHAG-- Mb2515c|M.bovis_AF2122/97 --EAIELFTDRAREARPELEITAD-NLALVTEICHRLDGIP-LAIELAAS Rv2488c|M.tuberculosis_H37Rv --EAIELFTDRAREARPELEITAD-NLALVTEICHRLDGIP-LAIELAAS Mvan_5928|M.vanbaalenii_PYR-1 --DAIELFTDRARRARPDFIISAD-DAAAVSEICHRLDGMP-LAIELAAA MMAR_0123|M.marinum_M --EATELFTDRARRVRPDFAVTDD-NTTAVTEICNRLDCMP-LAIELAAA MLBr_01753|M.leprae_Br4923 --EAVELFTERAALVQPGFSVTDG-NRQIVTEICQRLDGMP-LAIELAAA MUL_2743|M.ulcerans_Agy99 VSAAGTLFVERAQSVAPGFAPTDAQDAAAIGEICRRLDGIP-LAIELAAS MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 -AVYISANPLERRRIHGVLAGATDPGADPDRRAWHRAHAAAGTDEAIAWE TH_3225|M.thermoresistible__bu -AAYRAADPRDRRAVHRALAEATDPGADPDRRAWHAANGVTGTDDAVAAE Mflv_4504|M.gilvum_PYR-GCK --VYTDAGPTARRAMHRAIASVES---HPELRARHLALAASSGDDEIFAA MAV_2362|M.avium_104 --------MVRTRQLNGKLARALQKHERTGSRHLRLPHLQS--RIRLAEF Mb2515c|M.bovis_AF2122/97 RVRALALTEIVDSLHDRFRLLTGGSRIAVRRQQTMRASVDWSHALLTGPE Rv2488c|M.tuberculosis_H37Rv RVRALALTEIVDSLHDRFRLLTGGSRIAVRRQQTMRASVDWSHALLTGPE Mvan_5928|M.vanbaalenii_PYR-1 RVRALSLTEIVDGLHDRFRLLTGGSRTAVRRQQTLRASVDWSHGLLTDPE MMAR_0123|M.marinum_M RVRALSIDEIRTGLHDRFRLLTGGARTVVRRQQTLRASVDWSHALLTEPE MLBr_01753|M.leprae_Br4923 RIRTLSLTEIADGLDDRFRLLTGGARTAVRRQQTLRASMDWSYALLTESE MUL_2743|M.ulcerans_Agy99 RMASMTPIEVRDRLDHRFRLLVG-SRRGLGRHQTLRHAVAWSYDHLSDAE MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 LEQSAGRAQAKGGVLAAAAFLQRATELTADPAARGRRALAAAQSKYDAAA TH_3225|M.thermoresistible__bu LEKSAARAQQRGGIAATATFLERAVVLTADPGLRGRRALAAAQAKRDAAD Mflv_4504|M.gilvum_PYR-GCK LDQAADSARARGAPAAAAELMDLALGLGAHDPMRRLKAAENHFLAGDTAK MAV_2362|M.avium_104 MLHSDMEPDLDVITEAARDALAMSNVQLGEELARFALDRGGGLPAALVLA Mb2515c|M.bovis_AF2122/97 QVLFRRLAVFPSGFDLDGAQAAAAGGDVQR-YEVVDLLSLLADKSLVVTD Rv2488c|M.tuberculosis_H37Rv QVLFRRLAVFPSGFDLDGAQAAAAGGDVQR-YEVVDLLSLLADKSLVVTD Mvan_5928|M.vanbaalenii_PYR-1 RVLFRRLAVFAGGFDLDGAQAITVDGEVHR-YEVVDLLTLLVDKSLLIAE MMAR_0123|M.marinum_M RVLFRRIAVFLGGFDLDAAQAVAGDSQVQR-YQVVDELALLVDKSLVIAE MLBr_01753|M.leprae_Br4923 RALFRRLSAISGTFDLKVAYAVGHDDLEEP-DQVFDRLTMLIDKSLVIVE MUL_2743|M.ulcerans_Agy99 KVLLERCSVFAGGFDLQSACAVAGSADTHDDYEVLDLLDALVGKSLLIVD MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 FDAARELLGVADMTPLDPLARARATRLRAK----IAFAESRVGAFGSVTV TH_3225|M.thermoresistible__bu SAAAHDLLAIAERAPLSALEWARAVHLRAQ----LEFARSRAGDAGGPPV Mflv_4504|M.gilvum_PYR-GCK AAAALGEVGSIEPPILRAMATSLLATVRMY-----DNEHRQAVDLLRSAL MAV_2362|M.avium_104 EAVSWQGRGEEAGFVLAHAEPDGDDDWLIARWGCLRAANLFWGCGDAEAA Mb2515c|M.bovis_AF2122/97 DSDGRTRYRLLETVRQYALEKLRESGDADAVRARHRDHYAAVAAGLDAPS Rv2488c|M.tuberculosis_H37Rv DSDGRTRYRLLETVRQYALEKLRESGDADAVRARHRDHYAAVAAGLDAPS Mvan_5928|M.vanbaalenii_PYR-1 NTAGRTRYRLLETVRQYAQEKLGESGEADTLRARHRDHYTARAAELDAPS MMAR_0123|M.marinum_M SGGGPTRYRLLETVRQYAQEKLAESGEVEAVRSRHVTYYKSVAKLLDAPT MLBr_01753|M.leprae_Br4923 GRQGGSRYRLLETVRQYAMKKLEESNEVDLVLARHRDHYMALGALLDTPG MUL_2743|M.ulcerans_Agy99 RLSGRSRFSMLETIREFAEEQLVTRGQALAARTAHARHFAQRLPDVAAVW MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 SEAAIGLVEAARCLENLDDNLARETYLDAVGAAMYGGRLCPRGGAVEVAE TH_3225|M.thermoresistible__bu GQTAAALLTAAQLLQDVDAPAARESYLEAFAALMYAGRLAPSGALLEAAD Mflv_4504|M.gilvum_PYR-GCK DDAADNVPVQVQVLLRLSFALNSIGELDDAR--RYARDAVKLAEELGFPG MAV_2362|M.avium_104 RREADTVKKRVSSEAGLHLIDALELSMAFFRGDVETTTELGPGLCESDAV Mb2515c|M.bovis_AF2122/97 VAG-HERRLNQAELEIDNLRAAFAFSRENGDTGHALLLASCLQPLWRARG Rv2488c|M.tuberculosis_H37Rv VAG-HERRLNQAELEIDNLRAAFAFSRENGDTGHALLLASCLQPLWRARG Mvan_5928|M.vanbaalenii_PYR-1 VAG-HERRLNQTDIEMDNLRAAFAWSRENANTDHSLLLASSLHPLWRARG MMAR_0123|M.marinum_M GTD-HERRLAQAEDELDNLRSAFGWSLETRDFDSALELATSLHPVWMTRG MLBr_01753|M.leprae_Br4923 DID-HEQLVEQVETELDNLRSAFAWSRETGDIAGALQLASSLQPIWFGRG MUL_2743|M.ulcerans_Agy99 DSPRQPEAYTWLTAELANLRLAFRWTADNNDLDDAASIATWVGFLGFLVN MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 PARLAPAGAQP-ARPSDLLLDGLARRITHGAAASAQTLGEALTLIRCEAD TH_3225|M.thermoresistible__bu AVQAAFARAPEGSRAVDAFCQGMTQRIVGGISAAAAPLRVALTAMCELAR Mflv_4504|M.gilvum_PYR-GCK ATSAALAWAVHVDFQCGRGLDETALARAMKLYDSTFDVPIIFR------- MAV_2362|M.avium_104 PMATTWAAVPTCAALAATGRYSEVGRIADIGVRAAMSCGMGLHRFN---- Mb2515c|M.bovis_AF2122/97 RLQEGLAWFAAALADHDAHPAGA---------DPGLYARALADRALIDAV Rv2488c|M.tuberculosis_H37Rv RLQEGLAWFAAALADHDAHPAGA---------DPGLYARALADRALIDAV Mvan_5928|M.vanbaalenii_PYR-1 RLQEGQAWFDAALTDYEARPGEA---------DPAVYARALADRAFMDGH MMAR_0123|M.marinum_M QGREGLAWLEAGLGNEAGLGNEAGLGNEDVQVSPSTLARALADKVTLLAW MLBr_01753|M.leprae_Br4923 HMYEGLAWFDSIFEHKNIEHLVA---------PKEVLARAVANKVMLHAI MUL_2743|M.ulcerans_Agy99 R-FEPLTWVEEAIER----------------------------------- MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 -RPANTS------------------------------------------- TH_3225|M.thermoresistible__bu SRPAEVVH------------------------------------------ Mflv_4504|M.gilvum_PYR-GCK -------------------------------------------------- MAV_2362|M.avium_104 -------------------------------------------------- Mb2515c|M.bovis_AF2122/97 AG-----ITDRLDDAQKALAIARDIEDPALLARALTACGGVAAYNADLAR Rv2488c|M.tuberculosis_H37Rv AG-----ITDRLDDAQKALAIARDIEDPALLARALTACGGVAAYNADLAR Mvan_5928|M.vanbaalenii_PYR-1 VG-----ITDRLDQAQKALAMARDIDDPALLVRALTACGGLAAYNADVAR MMAR_0123|M.marinum_M TG-----SMAGFDDAERALTIARELADPALLIRALVARGVITAYDADVAR MLBr_01753|M.leprae_Br4923 LASSPPDGSDLVTQAQQALTMAREIGDSAVLARALTACGFSSGYDTEVAR MUL_2743|M.ulcerans_Agy99 -----------------------AVDHPKLAFLHVLASQCYTTGRVQEAI MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 --------------------------WMEQAFPIALESATHEVWDDDMWH TH_3225|M.thermoresistible__bu --------------------------WLVPAFPVLQESAGHELWDENLVD Mflv_4504|M.gilvum_PYR-GCK -------------------------------APFVHALAMSWTGRLEQAH MAV_2362|M.avium_104 -------------------------------IGISEIIAATDAGDDRAAE Mb2515c|M.bovis_AF2122/97 PWLAEAVGLARAVGDKWRLAEVLAWQAYVGFAGEGDPGATRAAGEEARSL Rv2488c|M.tuberculosis_H37Rv PWLAEAVGLARAVGDKWRLAEVLAWQAYVGFAGEGDPGATRAAGEEARSL Mvan_5928|M.vanbaalenii_PYR-1 PLLAEAVDLARSMGDKWMLAETLAWQAYAALMGGGDPVAARTAGEEAREL MMAR_0123|M.marinum_M PYFDEAAQLARELGDSWRLSQILSLQTRAAMAAG-DPIALEAAGEEGLRI MLBr_01753|M.leprae_Br4923 PYFAEAVELARTQGDKWTLSQIRLWG-VVGFCVSGDPVALRAAAEAADDL MUL_2743|M.ulcerans_Agy99 RYADEAARLLAT--DRYEVPFGIEGWPSGACTSSGHPEQSVELCRTQLAL MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 HLATRAVHIAREVGALSLLPAALIYRAGMHVHAGELDAAAELVQEADAIS TH_3225|M.thermoresistible__bu ALSEAVVRQARDAGALAGLPQALVYRAGVHLLFGEFGLADTLLTEAESIT Mflv_4504|M.gilvum_PYR-GCK QELTAVRGVCLERGAESDMMAIAGFLAINHLWRGQITDAEAEAAEAVERA MAV_2362|M.avium_104 RIYKRYAAMAEGLPGAEAMVD--AMLGVVRLARGEFPAACAAFTRSISLF Mb2515c|M.bovis_AF2122/97 ADEIGDAFLSRSCRWALAAANLWQGNLEAAVGLSREVIGESDAAHDMVSS Rv2488c|M.tuberculosis_H37Rv ADEIGDAFLSRSCRWALAAANLWQGNLEAAVGLSREVIGESDAAHDMVSS Mvan_5928|M.vanbaalenii_PYR-1 ADEMGDGFVSRICGWLLGIAHHFQGDLDAALALADGVVSESDVAHDTLNG MMAR_0123|M.marinum_M AEAIGDRTTSRECRGALGWVRAWRGDPIGALHQLGEAIAEASAAHDLLLL MLBr_01753|M.leprae_Br4923 AQEIGDRFVSLQCRLLLSIAQLWQGDMDGAIVRSGEVVAGAEAAHDTVTR MUL_2743|M.ulcerans_Agy99 GHDTHTLTLG-----CLVLALTIKGQCDEAEQLADALIESAEATRNPAAL MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 AATGH-----APIRYHSLILAAWRGSEPTAIRLIDEAMRDGAARGEGRLL TH_3225|M.thermoresistible__bu AATDHR----GPVRYHRLIIAAWRGDAVEAARLIEAAAADGEARGEGRLM Mflv_4504|M.gilvum_PYR-GCK EQLGGDDVLIIPMT-VRGAIAAYAGRVDDARADARWVLAAVRNRKASHIA MAV_2362|M.avium_104 AKGFPSP--------WLVVVGAFQAQAEGARGDSTAAAAALWRADRAYGP Mb2515c|M.bovis_AF2122/97 CAGQACLAHALAHRGDTEAA-AAAQASIDTAVGLSPVLSGSACSALVFAT Rv2488c|M.tuberculosis_H37Rv CAGQACLAHALAHRGDTEAA-AAAQASIDTAVGLSPVLSGSACSALVFAT Mvan_5928|M.vanbaalenii_PYR-1 CCGELVLAHSLAQRGDTDAARAAAQVSLNVAVEVSPVHAGLAHAALAVAN MMAR_0123|M.marinum_M MISQVVQGFTYAYVGDADGACACADAVFTSSAELVGANEGLGYATAAIAC MLBr_01753|M.leprae_Br4923 TFGLYVQTRALVHR-DVSAALVTAGLVVEAAAELSGVYQGIGYAAMVFAA MUL_2743|M.ulcerans_Agy99 CYALLAYGFTFRDTNPASALAAMRRG------------------------ MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 GAMGYAAGVLNNSLGRYELAFMAARR------------------------ TH_3225|M.thermoresistible__bu GLTGYAAALLYNGIGRYREALAAART------------------------ Mflv_4504|M.gilvum_PYR-GCK DWPGMTLCFLEESLGNHREALAALDDS----------------------- MAV_2362|M.avium_104 HAAVFLPELELARAWERAAA------------------------------ Mb2515c|M.bovis_AF2122/97 LAAGDVAAAEHARESATRFFGASAAAIINDPTSSAQISCARGDLNAAHRL Rv2488c|M.tuberculosis_H37Rv LAAGDVAAAEHARESATRFFGASAAAIINDPTSSAQISCARGDLNAAHRL Mvan_5928|M.vanbaalenii_PYR-1 LAAGDVTAAEAASDSATRSFGPSEVAGIQDPNVAAQIACTRGDLDTARSL MMAR_0123|M.marinum_M QAAGDATAAWKAYQKARELVGMDPQMAGVFP-FGALAPLVSGDLSAARRW MLBr_01753|M.leprae_Br4923 LAMGDVAAAVEASEACRPHLGADHGLVAIHLELMAAVALARGDVIVARRL MUL_2743|M.ulcerans_Agy99 -----------------------------------------------LRI MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 -------------------------------------------------- TH_3225|M.thermoresistible__bu -------------------------------------------------- Mflv_4504|M.gilvum_PYR-GCK -----------------------------------------------FIA MAV_2362|M.avium_104 -------------------------------------------------- Mb2515c|M.bovis_AF2122/97 ADGAASITRGVHRARALTTRCRIEIAQGDRHRAERDAHDALGVAASIGAY Rv2488c|M.tuberculosis_H37Rv ADGAASITRGVHRARALTTRCRIEIAQGDRHRAERDAHDALGVAASIGAY Mvan_5928|M.vanbaalenii_PYR-1 VDGAVSITRGVHRASALTTRARIAIAQGDPEQAERNAHDALSLAAGVGAR MMAR_0123|M.marinum_M ADDVVSTSYGCYLSVALTARARVALAQGELGQADRDSHAALSCSAANGTT MLBr_01753|M.leprae_Br4923 ADNSVSATTGWHQMAALTTRARIAMAQGEPELARADIHAALACGADIQAS MUL_2743|M.ulcerans_Agy99 AQDTGNRNSETHLAAVLCR---VEAKYGDPLSALDHFTLAIHNHHEAGNT MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 ACEHEDLGLYSWCLIELIEAAVRCGEHDTAVKAFGQLEERALAAQSDWSQ TH_3225|M.thermoresistible__bu TCEYEDLGFYSWCLHELVEAAARVGETDTAHRALGDIEERAGASGTPWGL Mflv_4504|M.gilvum_PYR-GCK AGPPTTELMYAWHLPDAIEAMVGVGRLDDAEILTAALERNGVEHDRRWMR MAV_2362|M.avium_104 -GDTQAATTHATQAAEIARAAGMHAAEMRTRHAAVRFGDRSQTARLERLA Mb2515c|M.bovis_AF2122/97 LWVPDILECLASVM----ADAGSNREAVRLFGAADAARGRMGAVRFGIYQ Rv2488c|M.tuberculosis_H37Rv LWVPDILECLASVM----ADAGSNREAVRLFGAADAARGRMGAVRFGIYQ Mvan_5928|M.vanbaalenii_PYR-1 LEVPDTLECLARVV----GDGGSHHEAARLCGAAEAIRGRTGAVRFRIYD MMAR_0123|M.marinum_M LGVADTLECLAELA----ATEGDRREAARLLASAEAIRHRTGEVRLKILD MLBr_01753|M.leprae_Br4923 LGISDSMELLAELI----SQGDNHRQAGRLFGAASAQREKTGEVRFKVWD MUL_2743|M.ulcerans_Agy99 TLISTPLAVLAAFF----DRLGRYEAAATIAGFAFHPITEASFP------ MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 GMVARSRALITVGH----DAEPHYREAIQRLTNTRISAHLARAHLIYGEW TH_3225|M.thermoresistible__bu GALAGARALLADGD----EADRLFREALDHLSRSRVVVHRARVHLTYGEW Mflv_4504|M.gilvum_PYR-GCK AVGARCRAMLLAAHGDVAAAEQMAHRAISEHDHLPMPFERARTRLLLGQL MAV_2362|M.avium_104 RILDTPLAEAAADH-----ARGLTQRDGDLLDAAAQQFADLGALACAADA Mb2515c|M.bovis_AF2122/97 AGCNSSLATLRKSMGDSEFDDAWAEGTALSIDEAIAYAQRGRGARKRPTS Rv2488c|M.tuberculosis_H37Rv AGCNSSLATLRKSMGDSEFDDAWAEGTALSIDEAIAYAQRGRGARKRPTS Mvan_5928|M.vanbaalenii_PYR-1 ADHETTVTTLRDALGDKAFEAAWTEGSATSITEAIAYAQRGRGERKRPSS MMAR_0123|M.marinum_M AHCEVVLAELRNELGEQDFAAVWGQGAVISTDEVISYVRRGRGTRRRPSS MLBr_01753|M.leprae_Br4923 AGYESAVAVLRGAMGCKDFDSAWAEGAAMPIDDAITYAQRGRGNRKRPTT MUL_2743|M.ulcerans_Agy99 -ELRTTISHLRDALGDHAYESFSQSGAAMTTAAMATYAYHQIDHARTEFQ MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 LRRCNRRSDARTELTAAHGSFVNMGTAAFAERAERELRATGAKVRKRSAS TH_3225|M.thermoresistible__bu LRREHRRGEARRELNEAHGMFTRMGAQGFAERSRRELIAVGEKVRRQPLT Mflv_4504|M.gilvum_PYR-GCK QRRLRQKATAAKNLTDALHTFEQLGTPLWAQRARSELAR-------AVVA MAV_2362|M.avium_104 AAQAAGEHARRGDRGKKFESSAWAH--ALASRYELHTPAVEAAARPLPFS Mb2515c|M.bovis_AF2122/97 GWGALTPTELEVALLVGEGLSNKEIGVRLFISPRTVHSHLTHVYTKLGLS Rv2488c|M.tuberculosis_H37Rv GWGALTPTELEVALLVGEGLSNKEIGVRLFISPRTVHSHLTHVYTKLGLS Mvan_5928|M.vanbaalenii_PYR-1 GWASLTPTELDVVGLVSEGLSNKDIAARLFVSPRTVQTHLTHVYTKLCLA MMAR_0123|M.marinum_M GWGSLTPTEHDVVRLVQEGLSNKDIAARMFISPRTVQTHLTHVYTKLGLT MLBr_01753|M.leprae_Br4923 GWESLTPAEHNVIRLVSEGLDTKDIAARLFVSVRTVHTHLTRIYSKLGLT MUL_2743|M.ulcerans_Agy99 AR------------------------------------------------ MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3361|M.abscessus_ATCC_1997 SEKALTAQEAQIARMAGQGLTNQEIAAQLFISSHTVEWHLRKVFAKRGIT TH_3225|M.thermoresistible__bu SGDELTAQEAQIAGLAADGLTNQEIGAQLFLSVHTVEWHLRKVFVKLGIT Mflv_4504|M.gilvum_PYR-GCK PAEGLTPSEQKVAEMAAAGATNKDIAAAMFISSKTVEHNLTRIYRKLGIS MAV_2362|M.avium_104 G------RERQIVNLVAAGLSNREIADRLVISVRTVEGHLYRLFTKLGIN Mb2515c|M.bovis_AF2122/97 SRLQLAQQAARRGESERGPSRP---------------- Rv2488c|M.tuberculosis_H37Rv SRLQLAQQAARRGESERGPSRP---------------- Mvan_5928|M.vanbaalenii_PYR-1 SRVQLAQEAARHT------------------------- MMAR_0123|M.marinum_M SRIQLVHEVARHA------------------------- MLBr_01753|M.leprae_Br4923 SRVQLVQEAARHN------------------------- MUL_2743|M.ulcerans_Agy99 -------------------------------------- MSMEG_0545|M.smegmatis_MC2_155 -------------------------------------- MAB_3361|M.abscessus_ATCC_1997 SRRQLRSGR----------------------------- TH_3225|M.thermoresistible__bu SRRQLRAAPRVTATW----------------------- Mflv_4504|M.gilvum_PYR-GCK SRAELGRRMDQPGL------------------------ MAV_2362|M.avium_104 SREQLTLLVAREPRGRRELLGHSNPSLGDQDDVHPHAG