For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MSITTTVAIAGAGIGGLTAALALQQRGFEVVVLESAHELRPLGVGINLLPHAVRELDHLGLGDAVGDASV APTAIRFYSADGTLLFTEPRGLAAGDTHPQLSIHRGRLQMLLLAAVRERLGADAVRTGARVSGFHDDGSR VVVRTDAGDVRADVLVGADGIGSVVRAALHPGPDPLRFSGITMFRGAGRMAAFLDGHTMAIVKGDRGDQG VDLVTYPIAPDLVNWVVQVPQSAPTSAGWNTPASAADVLPHVAGWRLDWLDVDSLIGSTPQIFTYPMVDK DPVRQWGRGGRVTLLGDAAHPMYPVGANGGSQAVVDARVLADHLAEAGVRGLRTYEAERADETAAVIVAN REMHRAANTRSATELDRVTRKYRTDTARSTRA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3841 | - | - | 100% (382) | hypothetical protein MSMEG_3841 |
| M. smegmatis MC2 155 | MSMEG_4641 | - | 2e-25 | 33.85% (322) | salicylate hydroxylase |
| M. smegmatis MC2 155 | MSMEG_6489 | - | 2e-12 | 28.00% (350) | hypothetical protein MSMEG_6489 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1290 | - | 8e-11 | 30.29% (175) | hypothetical protein Mb1290 |
| M. gilvum PYR-GCK | Mflv_2621 | - | 5e-32 | 31.44% (369) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv1260 | - | 2e-13 | 27.09% (347) | hypothetical protein Rv1260 |
| M. leprae Br4923 | MLBr_02276 | - | 7e-07 | 30.00% (160) | putative FAD-linked oxidoreductase |
| M. abscessus ATCC 19977 | MAB_2237c | - | 1e-102 | 52.45% (387) | hypothetical protein MAB_2237c |
| M. marinum M | MMAR_4944 | - | 5e-23 | 28.37% (356) | oxidoreductase |
| M. avium 104 | MAV_4429 | - | 3e-16 | 27.79% (367) | FAD binding domain-containing protein |
| M. thermoresistible (build 8) | TH_4641 | - | 6e-09 | 25.33% (375) | PUTATIVE oxygenase |
| M. ulcerans Agy99 | MUL_1770 | - | 3e-17 | 29.23% (349) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_3960 | - | 7e-30 | 33.75% (320) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_3841|M.smegmatis_MC2_155 --MSIT-TTVAIAGAGIGGLTAALALQQRGFEVVVLESAHELRPLGVGIN
MAB_2237c|M.abscessus_ATCC_199 --MSTDKTSIVVAGAGIGGLASALTLHAAGFEVVVLESAREVKPLGVGIN
Mflv_2621|M.gilvum_PYR-GCK -----MSARISVIGAGISGLAAAVALERAGHHVSVIEQRTDTG-AGSGIS
Mvan_3960|M.vanbaalenii_PYR-1 -----MPAHTIVIGAGIAGLATAVALRRVGHDVTVIEQRTDLT-SGAGIS
Mb1290|M.bovis_AF2122/97 ------MKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLRPGGQAID
Rv1260|M.tuberculosis_H37Rv ------MKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLRPGGQAID
MUL_1770|M.ulcerans_Agy99 ----MAKPIVLISGAGIAGPALAFWLTHSGYQVVVTELADDIRPGGQTVD
MMAR_4944|M.marinum_M -------MKAVIIGAGIGGMSAAIALRQIGIDTEVYERVTENKPVGAAIS
MAV_4429|M.avium_104 MVGDARPLRVLVVGAGVAGISVARGLLRDGHDVTVFERRPRLAAAGGAVT
TH_4641|M.thermoresistible__bu -MARETTTDVVVVGAGPVGLAVACGLLAHGLDVRVIDKAPAPATTSRANF
MLBr_02276|M.leprae_Br4923 -MRVETSADVVVVGAGPAGSAAATWAARAGNDVIVIDSVCFPRDKACGDG
: **. * : * * . : : .
MSMEG_3841|M.smegmatis_MC2_155 LLPHAVRELDHLGLGDAVGDASVAPTAIRFYSAD-GTLLFTE-PRGLAAG
MAB_2237c|M.abscessus_ATCC_199 MLPHAVGVLTELGLGERLTRMGIATTEIRFCDKH-GTVLFTE-PRGLAGD
Mflv_2621|M.gilvum_PYR-GCK LWPNALAALDQIGLGDSVRDAGGRVTAGAIRWRD-GTWVRRPSVRRIVDA
Mvan_3960|M.vanbaalenii_PYR-1 IWPNALAALDQIGLGDNVRQAGGRVTAGAIRWRD-GTWLRRPSAQRIVHA
Mb1290|M.bovis_AF2122/97 VRGPALDVLERMGLLAAAQEHKTRIRGASFVDRD-GNE-LFRDTESTPTG
Rv1260|M.tuberculosis_H37Rv VRGPALDVLERMGLLAAAQEHKTRIRGASFVDRD-GNE-LFRDTESTPTG
MUL_1770|M.ulcerans_Agy99 LRGAGRLVIERMGLLEQMRQRSLRQRGIAWIRAD-GRRRAEMPVEAFHGN
MMAR_4944|M.marinum_M VWSNGVKCLNYLGLEQQTARLGGIVETMSYAEAHSGETMCRISMQPLIEQ
MAV_4429|M.avium_104 VWSNGETVLRQLGVEMDG--AGRQLSSVGAVTST-GRPLATLDVTAMARR
TH_4641|M.thermoresistible__bu LHARGSEVLDRLGALGGLPERSVR--AMQITTHLGGEPVMRMQFGDPGMR
MLBr_02276|M.leprae_Br4923 LTPRAVAELKRLGLDDWLN-TRIRHRGLRMSGFG-GEVEVDWPGPSFPST
: . : :* *
MSMEG_3841|M.smegmatis_MC2_155 --DTHPQLSIHRGRLQMLLLAAVRERLGADAVRTGARVSGFHDDGS--RV
MAB_2237c|M.abscessus_ATCC_199 --YPHPQISVHRGRLQLMLLDAVRKRIGPQAVRTASRVLGFESDEA--GV
Mflv_2621|M.gilvum_PYR-GCK --LGEPLVVVRRSRLTDILREALP----AGTVRTGLAATRVSVGAS--SV
Mvan_3960|M.vanbaalenii_PYR-1 --LGEPLVVVRRSALTEILLDALP----PDTVQTGLSATALSIAAA--TA
Mb1290|M.bovis_AF2122/97 GPVNSPDIELLRDDLVELLYGATQP---SVEYLFDDSISTLQDDGD--SV
Rv1260|M.tuberculosis_H37Rv GPVNSPDIELLRDDLVELLYGATQP---SVEYLFDDSISTLQDDGD--SV
MUL_1770|M.ulcerans_Agy99 GPVS--ELEILRGDLAAVLYRATAA---GTDYRFGTRITDLAPSGD--AV
MMAR_4944|M.marinum_M --VGQRPYPIARAELQQMLMEAYG----IDEIHFGMKMVEVANRDG--AA
MAV_4429|M.avium_104 --LGAPVRMVPRRVLLERLLDGFP----TGRIHCDRRAVALATSRD--GV
TH_4641|M.thermoresistible__bu --TAAPPMVISQAEVEAALRNRLAELG--GRVELDCPLTGLRQDAS--TV
MLBr_02276|M.leprae_Br4923 ------SSAVPRLELDDRIRKVAENS--GARMLLGTKAVSVYHDSSRRAA
: : : : . .
MSMEG_3841|M.smegmatis_MC2_155 VVRTDAGDVR-ADVLVGADGIGSVVRAALHPG-PDPLRFSGITMFR--GA
MAB_2237c|M.abscessus_ATCC_199 RVRTATGDIE-AAVLVGADGVNSAIRAQLHP--ADRLHWSGVRMWR--GA
Mflv_2621|M.gilvum_PYR-GCK RITLSDGEVRESDAVVGADGVNSVLARTLNG--PLRTRYVGYTAWRGIAA
Mvan_3960|M.vanbaalenii_PYR-1 RVTLSDGRTREADAVVGADGVNSMVARALNG--PLPSRYVGYTAWRGVAA
Mb1290|M.bovis_AF2122/97 RVTFERAAAREFDLVIGADGLHSNVRRLVFG--PEEQFVKRLGTHAAIFT
Rv1260|M.tuberculosis_H37Rv RVTFERAAAREFDLVIGADGLHSNVRRLVFG--PEEQFVKRLGTHAAIFT
MUL_1770|M.ulcerans_Agy99 QARLSDGTTVRADLVVGADGPHSGVRRLAFG--PEEQFARPLGGYNAWFS
MMAR_4944|M.marinum_M TATFADGTIASADILIGADGANSITREYVLGG-PVTRRYAGYVNYNGLVE
MAV_4429|M.avium_104 SVEFTDGTVAEGDVLIGADGLHSMVREWVGA---RHAKATGWCSWQGLVS
TH_4641|M.thermoresistible__bu TAGIGGGGELRGRWLVGCDGTGSSTRKSVGIGYPGARLSERFLLADVYLD
MLBr_02276|M.leprae_Br4923 SVTLADGTEVGCRQLIIADGARSPLGRKLGRS-WHQKTVYGVAARGYLTT
. :: .** *
MSMEG_3841|M.smegmatis_MC2_155 GRMAAFLDGHTMAIVKGDRGDQGVDLVTYPIAPDLVNWVVQVPQS----A
MAB_2237c|M.abscessus_ATCC_199 SDVGPFLTGKTMVVAHDDTDH---ELIAYPISDRTVNWVALARTNPAGEL
Mflv_2621|M.gilvum_PYR-GCK HPLDPELGGETLGPGT--------QVGHVPLGPDHTYWFATERTA-----
Mvan_3960|M.vanbaalenii_PYR-1 YRLDPALAGETMSAGT--------EVGHVPLGPDHTYWFATERTR-----
Mb1290|M.bovis_AF2122/97 VPNFLELDYWQTWHYG-DSTMAGVYSARNNTEARAALAFMDTELR-----
Rv1260|M.tuberculosis_H37Rv VPNFLELDYWQTWHYG-DSTMAGVYSARNNTEARAALAFMDTELR-----
MUL_1770|M.ulcerans_Agy99 APDTVGLNGWYLMYQAPGGLNASMRPSHDPATAKAGLAFRSAPIR-----
MMAR_4944|M.marinum_M VDEAISPANEWTMYVG-----DGKRVSAMPVADDRFYFFFDVVEP-----
MAV_4429|M.avium_104 LPEIAESDAALMMIGG------SGNLGLWPAGGAEVQWWFDLPWS-----
TH_4641|M.thermoresistible__bu WRLDRSGTTGWIHPDG--------MVGAMPMPDGLWRIIAYDPGP-----
MLBr_02276|M.leprae_Br4923 PRSDDLWLTSHLELRSPDGAVLPGYGWIFPLGNGEVNIGVGALST-----
MSMEG_3841|M.smegmatis_MC2_155 PTSAGWNTPASAADVLPHVAGWRLDWLDVDSLIGSTPQIFTYPMVDKDPV
MAB_2237c|M.abscessus_ATCC_199 PAGARWNDPATADEVLDHFPGWDFGWLDLDKMIRGAEYVVEYPMVDRDPL
Mflv_2621|M.gilvum_PYR-GCK --EGGSAPGGEHAYLTAKVADWADPIPRLVATTD-PGDLLRNDLYDRARA
Mvan_3960|M.vanbaalenii_PYR-1 --EGSRSAGGEHAYLTAKLAGWADPIPALLASTD-PADVLRNDLYDRAQP
Mb1290|M.bovis_AF2122/97 --IDYRDTEAQFAELQRRMAEDGWVRAQLLHYIAAH----------RISI
Rv1260|M.tuberculosis_H37Rv --IDYRDTEAQFAELQRRMAEDGWVRAQLLHYMRSAPDFYFDEMS-QILM
MUL_1770|M.ulcerans_Agy99 --YDRGDLDAQRDLLAACFAGAGWQSDALIAAAREADDFYLDAIV-QIHL
MMAR_4944|M.marinum_M -EGLPFEKGTAREVLREQFAGWAPGVQALIDKLD-PTTTNRVEILDLDPF
MAV_4429|M.avium_104 --TGFVRPQHPIETIRSHFAGWSEPVDRVLAILTDEDLAASPFPHFRHPI
TH_4641|M.thermoresistible__bu ---GDLDQGALERLLYERTG----------HRVKVTGTVWQSEFRVHRRL
MLBr_02276|M.leprae_Br4923 -------SKRPADLALRSLISYYTDLRRHEWGFSGQPRAVSSALLPMGGA
MSMEG_3841|M.smegmatis_MC2_155 RQWGRGGRVTLLGDAAHPMYPVGANGGSQAVVDARVLADHLAEAG-----
MAB_2237c|M.abscessus_ATCC_199 PHWGRD-RVTLLGDAAHPMYPLGANGGSQSVVDARALAVALAGHPG----
Mflv_2621|M.gilvum_PYR-GCK ARWSDG-RAVLIGDAAHPMRPHLGQGGCQGIEDAAILARFLELAD-----
Mvan_3960|M.vanbaalenii_PYR-1 RDWSRG-PAVIVGDAAHPMRPHLGQGGCQGLEDAAILARFVGLSP-----
Mb1290|M.bovis_AF2122/97 STKCRR-S------------------------------------------
Rv1260|M.tuberculosis_H37Rv DRWSRG-RVALVGDAGYCCSPLSGQGTSVALLGAYILAGELKAAGD----
MUL_1770|M.ulcerans_Agy99 DAWSRG-RVTLVGDAGYCASPLSGMGTSLALVGAYVLAGELGPAHG----
MMAR_4944|M.marinum_M HTWVKG-RVAVLGDAAHNTTPDIGQGGCSAMEDAVALQWALKDNPT----
MAV_4429|M.avium_104 PPPGRG-RVTLLGDAAHTMPPTLAQGTNQALLDTMVLCQALADFGRGTP-
TH_4641|M.thermoresistible__bu ADTYRRGRVFIAGDAAHAHAPFGGQGMLTGLGDAENLAFKLALVIRGYAG
MLBr_02276|M.leprae_Br4923 VSGVAGPNWMLIGDAAACVNPLNGEGIDYGLETGRLAAELLDLRDLS---
MSMEG_3841|M.smegmatis_MC2_155 ------VRGLRTYEAER--ADETAAVIVANREMHRAANTRSATELDRVTR
MAB_2237c|M.abscessus_ATCC_199 ----DPAGGLSAYESQR--IAATHEVVLANRAMLRSWGDQSPEGLRKTAQ
Mflv_2621|M.gilvum_PYR-GCK ----DVPTAFERFEAFR--KPRVGMLVREAQTLGRIVNVRPAVLSGLAGR
Mvan_3960|M.vanbaalenii_PYR-1 ----DLPAAFDRFGAFR--RRRVRPLVRESAAIGRIVNLRPAFLSGVASR
Mb1290|M.bovis_AF2122/97 --------------------------------------------------
Rv1260|M.tuberculosis_H37Rv ----D------YQLGFANYHAEFHGFVERNQWLVSDNIPGGAPIPQEEFE
MUL_1770|M.ulcerans_Agy99 ----DGIDEAALAAALARYETVLRPYVANCQDLP-NSIDRFLPMSESEIR
MMAR_4944|M.marinum_M ----DVAAALAAYQASR--TERAGDLVLRARKRCDVIHAKDPDTTAAWYE
MAV_4429|M.avium_104 GGQADVANALRWYEKTRRRRVRAVSWVASLPVSHGEAVLRPAALVSDRLQ
TH_4641|M.thermoresistible__bu PALLDTYEAERRPLATEVLRNTSAATKLNIADRGVGRFLRDRVVLPLLAL
MLBr_02276|M.leprae_Br4923 ---YVWPSLLQQHYGRGFSVARRLALLLTFKRCLPAIGPSAMRSTSLITI
MSMEG_3841|M.smegmatis_MC2_155 KYRTDTARSTRA--------------------------------------
MAB_2237c|M.abscessus_ATCC_199 SYR----RRTRA--------------------------------------
Mflv_2621|M.gilvum_PYR-GCK ATALIPERMVTAHLAWIAAGSAFVLPTAADLAR-----------------
Mvan_3960|M.vanbaalenii_PYR-1 ASALIPEWAVASHLASIAAGSAFILPTAGDVGG-----------------
Mb1290|M.bovis_AF2122/97 --------------------------------------------------
Rv1260|M.tuberculosis_H37Rv R-----------------------IVHSITIKDY----------------
MUL_1770|M.ulcerans_Agy99 SNAAAMKYMQRWPFRFFAERKWFTIAESIELPRYPRLP------------
MMAR_4944|M.marinum_M ELRNEDGTNIIRGLVANIMGGPLTPLS-----------------------
MAV_4429|M.avium_104 AAALTMFLRWTSHRRMSDHINRSVGEAINRSLGEAPKIPSRR--------
TH_4641|M.thermoresistible__bu PSVQRRLTYQTSQLWVTYRGGPLAPRTVSMTTPRPGDRVPDQRCVRDDGH
MLBr_02276|M.leprae_Br4923 AVRVMANLVTDDDADWVARVWRSGGWASWLVDRRPPFS------------
MSMEG_3841|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2237c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3960|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1290|M.bovis_AF2122/97 --------------------------------------------------
Rv1260|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1770|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4944|M.marinum_M --------------------------------------------------
MAV_4429|M.avium_104 --------------------------------------------------
TH_4641|M.thermoresistible__bu ISRLYEQLGGRWAVLEPGSGRHHREGPGLLGTAHTFLGEYVVGLRGAEMR
MLBr_02276|M.leprae_Br4923 --------------------------------------------------
MSMEG_3841|M.smegmatis_MC2_155 -------------------------------------
MAB_2237c|M.abscessus_ATCC_199 -------------------------------------
Mflv_2621|M.gilvum_PYR-GCK -------------------------------------
Mvan_3960|M.vanbaalenii_PYR-1 -------------------------------------
Mb1290|M.bovis_AF2122/97 -------------------------------------
Rv1260|M.tuberculosis_H37Rv -------------------------------------
MUL_1770|M.ulcerans_Agy99 -------------------------------------
MMAR_4944|M.marinum_M -------------------------------------
MAV_4429|M.avium_104 -------------------------------------
TH_4641|M.thermoresistible__bu GCDAFLVRPDGHLAWRGRDATDLADWLKSALTVGRVR
MLBr_02276|M.leprae_Br4923 -------------------------------------