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VKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLRPGGQAIDVRGPALDVLERMGLLAAAQEHKTRIR GASFVDRDGNELFRDTESTPTGGPVNSPDIELLRDDLVELLYGATQPSVEYLFDDSISTLQDDGDSVRVT FERAAAREFDLVIGADGLHSNVRRLVFGPEEQFVKRLGTHAAIFTVPNFLELDYWQTWHYGDSTMAGVYS ARNNTEARAALAFMDTELRIDYRDTEAQFAELQRRMAEDGWVRAQLLHYMRSAPDFYFDEMSQILMDRWS RGRVALVGDAGYCCSPLSGQGTSVALLGAYILAGELKAAGDDYQLGFANYHAEFHGFVERNQWLVSDNIP GGAPIPQEEFERIVHSITIKDY
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1260 | - | - | 100% (372) | hypothetical protein Rv1260 |
| M. tuberculosis H37Rv | Rv0575c | - | 1e-59 | 40.63% (347) | hypothetical protein Rv0575c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1290 | - | 1e-149 | 99.62% (260) | hypothetical protein Mb1290 |
| M. gilvum PYR-GCK | Mflv_2621 | - | 2e-12 | 24.36% (349) | monooxygenase, FAD-binding |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2678 | - | 1e-73 | 43.82% (340) | hypothetical protein MAB_2678 |
| M. marinum M | MMAR_4180 | - | 1e-179 | 80.11% (372) | oxidoreductase |
| M. avium 104 | MAV_1408 | - | 1e-178 | 81.72% (372) | hypothetical protein MAV_1408 |
| M. smegmatis MC2 155 | MSMEG_5719 | - | 1e-63 | 43.20% (331) | oxidoreductase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_4482 | - | 1e-178 | 79.57% (372) | hypothetical protein MUL_4482 |
| M. vanbaalenii PYR-1 | Mvan_3960 | - | 1e-14 | 28.03% (314) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1260|M.tuberculosis_H37Rv ---MKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLR-PGGQAIDVR
Mb1290|M.bovis_AF2122/97 ---MKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLR-PGGQAIDVR
MAV_1408|M.avium_104 ---MSDVLVSGASVAGTAAAFWLGRHGHSVTVVERHRGPR-PGGQAIDVR
MMAR_4180|M.marinum_M MVGVQKVLISGASVAGLTTAYWLEQQGYSVTIVERHPGLR-PGGQAIDVR
MUL_4482|M.ulcerans_Agy99 MVGVQKVLISGASVAGLTTAYWLEQQGYSVTIVERHPGLR-PGGQAIDVR
MAB_2678|M.abscessus_ATCC_1997 ----MRVLISGASIAGPVLAFWLAHYGFEVTVIERSPAPRKSGGHAVDLF
MSMEG_5719|M.smegmatis_MC2_155 ----MKVLISGASIAGPVLAYWLSRHGFEVTVVERSPVLRKTGGHAVDLF
Mflv_2621|M.gilvum_PYR-GCK --MSARISVIGAGISGLAAAVALERAGHHVSVIEQRTDTG--AGSGISLW
Mvan_3960|M.vanbaalenii_PYR-1 --MPAHTIVIGAGIAGLATAVALRRVGHDVTVIEQRTDLT--SGAGISIW
: **.::* . * * : *. *:::*: .* .:.:
Rv1260|M.tuberculosis_H37Rv GPALDVLERMGLLAAAQEHKTRIRGASFVDRDGNELFRDTES---TPTGG
Mb1290|M.bovis_AF2122/97 GPALDVLERMGLLAAAQEHKTRIRGASFVDRDGNELFRDTES---TPTGG
MAV_1408|M.avium_104 GPALGVLERMGLLAAAAKRRTQIRGSSVVDRDGNELSRDTEAAISGPTGG
MMAR_4180|M.marinum_M GPALTVLDRMGILDAARDRKTGIRGASVVDRDGNELSQDTES---TPTGG
MUL_4482|M.ulcerans_Agy99 GPALTVLDRMGILDAARDRKTGIRGASVVDRDGNELSRDTES---TPTGG
MAB_2678|M.abscessus_ATCC_1997 KPAMDIIEMMGILDHVEAQSAGT-EVLSIHREGK-RLIDLPE---VLIFS
MSMEG_5719|M.smegmatis_MC2_155 RPAMEISERMGVLPEIEAHATGT-TSMVVHRPGTSRPARLDY---LKVVG
Mflv_2621|M.gilvum_PYR-GCK PNALAALDQIGLGDSVRDAGGRVTAGAIRWRDGTWVRRPSVR----RIVD
Mvan_3960|M.vanbaalenii_PYR-1 PNALAALDQIGLGDNVRQAGGRVTAGAIRWRDGTWLRRPSAQ----RIVH
*: : :*: * *.
Rv1260|M.tuberculosis_H37Rv PVNSPDIELLRDDLVELLYGATQPSVEYLFDDSISTLQDDGDSVRVTFER
Mb1290|M.bovis_AF2122/97 PVNSPDIELLRDDLVELLYGATQPSVEYLFDDSISTLQDDGDSVRVTFER
MAV_1408|M.avium_104 PIEGPDIELLRDDLVELLYGASQWTAEYLFDDTITALDDRGAAVRVSFER
MMAR_4180|M.marinum_M PIDSPNIELLRDDLIELLYGTIQSTTEFIFDDSIATLQDDGAAVEVTFVR
MUL_4482|M.ulcerans_Agy99 PIDSPNIELLRDDLIELLDGTIQSTTEFIFDDSIATLQDDGAAVEVTFVR
MAB_2678|M.abscessus_ATCC_1997 AVSERHVEIMRDDLSEILYGASAPSAEYIFGDSITALTDDGAGVRVAFDR
MSMEG_5719|M.smegmatis_MC2_155 VISDRHIEIMRDDLSEIYFRAGRDDVEYLFGDTITSISPDGD---VTFEH
Mflv_2621|M.gilvum_PYR-GCK ALGEPLVVVRRSRLTDILREALP-AGTVRTGLAATRVSVGASSVRITLSD
Mvan_3960|M.vanbaalenii_PYR-1 ALGEPLVVVRRSALTEILLDALP-PDTVQTGLSATALSIAAATARVTLSD
: : : *. * :: : . : : : . :::
Rv1260|M.tuberculosis_H37Rv AAAREFDLVIGADGLHSNVRRLVFGPEEQFVKRLGTHAAIFTVPNFLELD
Mb1290|M.bovis_AF2122/97 AAAREFDLVIGADGLHSNVRRLVFGPEEQFVKRLGTHAAIFTVPNFLELD
MAV_1408|M.avium_104 AAPRDFDLVIGADGLHSNVRRLVFGPEDEFIERLGTHAAIFTVPNFLGLD
MMAR_4180|M.marinum_M SGTRTFDFLIGADGLHSNVRRKVFGPEEQFIKRLGTYAAIFTVPNFLELD
MUL_4482|M.ulcerans_Agy99 SGTRTFDFLIGADGLHSNVRRKVFGPEEQFIKRLGTYAAIFTVPNFLELD
MAB_2678|M.abscessus_ATCC_1997 ASDRRFDLVIGADGLHSHVRGLVFGPESGYSHWLGQYLAVASIPNYLDLS
MSMEG_5719|M.smegmatis_MC2_155 HPPRRFDVVVGADGLHSGVRRLVFG-DNVSENFLAGYLSVVSVPKSLARD
Mflv_2621|M.gilvum_PYR-GCK GEVRESDAVVGADGVNSVLARTLNGPLRTRYVGYTAWRGIAAHPLDPELG
Mvan_3960|M.vanbaalenii_PYR-1 GRTREADAVVGADGVNSMVARALNGPLPSRYVGYTAWRGVAAYRLDPALA
* * ::****::* : : * .: :
Rv1260|M.tuberculosis_H37Rv YWQTWHYGDSTMAGVYSARNNTEARAALAFMDT-ELRIDYRDTEAQFAEL
Mb1290|M.bovis_AF2122/97 YWQTWHYGDSTMAGVYSARNNTEARAALAFMDT-ELRIDYRDTEAQFAEL
MAV_1408|M.avium_104 YWQMWHYGDSTMAGVYSARDNAEARAMLGFMDA-ELRLDYRDTEAQFAEL
MMAR_4180|M.marinum_M YWQKWHYGDNTMAGVYSARDNSEARAALGFMDT-ELQIDYRDTEAQFAEL
MUL_4482|M.ulcerans_Agy99 YWQKWHYGDNTMAGVYSARDNSEARAALGFMDT-ELQIDYRDTEAQFAEL
MAB_2678|M.abscessus_ATCC_1997 DRALMYPQVDKIAGMYSAAQLSDARAFFLFRTPEPLDYHHRDVGRQKALL
MSMEG_5719|M.smegmatis_MC2_155 GEMTSFLKPGHMAAVYTADHLEDARAVFIFRPSRPLDYDHRDVERQKAQL
Mflv_2621|M.gilvum_PYR-GCK G--------ETLGPGTQVGHVPLGPDHTYWFATERTAEGGSAPGGEHAYL
Mvan_3960|M.vanbaalenii_PYR-1 G--------ETMSAGTEVGHVPLGPDHTYWFATERTREGSRSAGGEHAYL
:. . . . : . : * *
Rv1260|M.tuberculosis_H37Rv QRRMAEDGWVRAQLLHYMRSAPDFYFDEMSQILMDRWSRGRVALVGDAGY
Mb1290|M.bovis_AF2122/97 QRRMAEDGWVRAQLLHYIAAH---------RISISTKCRRS---------
MAV_1408|M.avium_104 ERRMAGEGWVRPQLLEYMRTAPDFYFDEMSQIKMDRWSRGRVALVGDAGY
MMAR_4180|M.marinum_M ERRMIEDGWVRAQLLHYMRSAPDFYFDEMAQIVMDSWSKGRVALVGDAAY
MUL_4482|M.ulcerans_Agy99 ERRMIEDGWVRAQLLHYMRSAPDFYFDEMAQIVMDSWAKGRVALVGDAAY
MAB_2678|M.abscessus_ATCC_1997 GEVYADVGWELPRMLAEVDATDTFYMDSITQLRMDTWSKGRITLVGDAGY
MSMEG_5719|M.smegmatis_MC2_155 RAAFEHIAPEVDRWLDEVPRTPAFYFDAITQLEMTTWSRGRVTLVGDAGY
Mflv_2621|M.gilvum_PYR-GCK TAKVADWADPIPRLVATTDPGDLLRNDLYDRARAARWSDGRAVLIGDAAH
Mvan_3960|M.vanbaalenii_PYR-1 TAKLAGWADPIPALLASTDPADVLRNDLYDRAQPRDWSRGPAVIVGDAAH
. : : .
Rv1260|M.tuberculosis_H37Rv CCSPLSGQGTSVALLGAYILAGELKAAGDDYQLGFANYHAEFHGFV--ER
Mb1290|M.bovis_AF2122/97 --------------------------------------------------
MAV_1408|M.avium_104 CCSPLSGQGTSVALLGAYILAGELKAAGEDHEAGFANYHREFADYV--QR
MMAR_4180|M.marinum_M CCSPLSGQGTSVAVLGAYILAGELAAAGNDYQRGFANYHAEFSGFV--ER
MUL_4482|M.ulcerans_Agy99 CCSPLSGQGTSVAVLGAYILAGELAAAGNDYQRGFANYHAEFSGFG--ER
MAB_2678|M.abscessus_ATCC_1997 CPGPAVGGSTSLAVVGAYVLAGEIAAAAGDHARAYPAYEAALREYV--EV
MSMEG_5719|M.smegmatis_MC2_155 CPGPAVGGSTSLAVYGAYVLAAEMVRAGEDYPAAFDAYERTMLAPV--VG
Mflv_2621|M.gilvum_PYR-GCK PMRPHLGQGGCQGIEDAAILA-RFLELADDVPTAFERFEAFRKPRVGMLV
Mvan_3960|M.vanbaalenii_PYR-1 PMRPHLGQGGCQGLEDAAILA-RFVGLSPDLPAAFDRFGAFRRRRVRPLV
Rv1260|M.tuberculosis_H37Rv NQWLVSDNIPGGAP-----------------------------IPQEEFE
Mb1290|M.bovis_AF2122/97 --------------------------------------------------
MAV_1408|M.avium_104 NQWLVVDNIPGGAP-----------------------------IPQEVFE
MMAR_4180|M.marinum_M NQWLVTDNIPGGEP-----------------------------IPEEAFE
MUL_4482|M.ulcerans_Agy99 NQWLVTDNIPGGEP-----------------------------IPEEAFE
MAB_2678|M.abscessus_ATCC_1997 SRKLALTASGTLVPKSRLGLCTLVHGARILGHLPSSLTRSLSRLVAARRI
MSMEG_5719|M.smegmatis_MC2_155 SRKLARFNAKTVVPASGLGIRALVGVGQLISVLPVGLTRSLARLNDKG-V
Mflv_2621|M.gilvum_PYR-GCK REAQTLGRIVNVRPAVLSG----------LAGRATALIPERMVTAHLAWI
Mvan_3960|M.vanbaalenii_PYR-1 RESAAIGRIVNLRPAFLSG----------VASRASALIPEWAVASHLASI
Rv1260|M.tuberculosis_H37Rv RIVHSITIKDY------
Mb1290|M.bovis_AF2122/97 -----------------
MAV_1408|M.avium_104 RIVASITLKDY------
MMAR_4180|M.marinum_M RIVNSLELEDYRQG---
MUL_4482|M.ulcerans_Agy99 RIVNSLELEDYRQG---
MAB_2678|M.abscessus_ATCC_1997 NIHDTFALRDYQGLISR
MSMEG_5719|M.smegmatis_MC2_155 RLYDTMPLPQWPARLNG
Mflv_2621|M.gilvum_PYR-GCK AAGSAFVLPTAADLAR-
Mvan_3960|M.vanbaalenii_PYR-1 AAGSAFILPTAGDVGG-