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MAASFLVVGAGITGLATAAALQRRGHDVCVAEARADTASGAGISIWPNALAALDAIGLGDPVRAAGGRVT AGALRWHDGTWLRHPAAERITRALGEPLVVIRRRVLTEILSGALAPGTVVHGLEAHTVETCASGIRVTFS DGSVREASAVVGADGVDSVVARHLNGPLRRRYAGYTAWRGIAAHPLDPELSGETMGAGVEVGHVPLGADH TYWFATERASQGQRSPDGELTHLRRLFGSWAEPIPQLLAATDPADVLRNDLYDREPARCWARGPVVLAGD AAHPMRPHLGQGGCQGLEDAATLAALVAREPDLPTAFARFATLRRRRVTRMVRTSRMIGRIVNLRPAVLS AAASRATVLVPEAVLTRQLASIAARSAFTPVD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4641 | - | - | 100% (382) | salicylate hydroxylase |
| M. smegmatis MC2 155 | MSMEG_3841 | - | 2e-25 | 33.85% (322) | hypothetical protein MSMEG_3841 |
| M. smegmatis MC2 155 | MSMEG_1699 | - | 7e-15 | 28.73% (362) | pentachlorophenol 4-monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0590c | - | 5e-13 | 25.88% (313) | hypothetical protein Mb0590c |
| M. gilvum PYR-GCK | Mflv_2621 | - | 1e-140 | 64.81% (378) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv1260 | - | 1e-13 | 27.19% (331) | hypothetical protein Rv1260 |
| M. leprae Br4923 | MLBr_02276 | - | 4e-05 | 24.61% (382) | putative FAD-linked oxidoreductase |
| M. abscessus ATCC 19977 | MAB_1601c | - | 1e-107 | 51.46% (377) | putative monooxygenase |
| M. marinum M | MMAR_4944 | - | 4e-38 | 29.69% (357) | oxidoreductase |
| M. avium 104 | MAV_4429 | - | 3e-35 | 30.89% (369) | FAD binding domain-containing protein |
| M. thermoresistible (build 8) | TH_1880 | - | 2e-09 | 28.71% (310) | flavin-type hydroxylase |
| M. ulcerans Agy99 | MUL_0460 | - | 1e-18 | 30.73% (179) | hypothetical protein MUL_0460 |
| M. vanbaalenii PYR-1 | Mvan_3960 | - | 1e-145 | 68.78% (378) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2621|M.gilvum_PYR-GCK -----MSARISVIGAGISGLAAAVALERAGHHVSVIEQRTD-TGAGSGIS
Mvan_3960|M.vanbaalenii_PYR-1 -----MPAHTIVIGAGIAGLATAVALRRVGHDVTVIEQRTD-LTSGAGIS
MSMEG_4641|M.smegmatis_MC2_155 -----MAASFLVVGAGITGLATAAALQRRGHDVCVAEARAD-TASGAGIS
MAB_1601c|M.abscessus_ATCC_199 -----MSDHIVVVGAGIAGLATAVAIQQSGRDVVVVDDRDG-TSAGYAIT
MMAR_4944|M.marinum_M ------MKAVIIG-AGIGGMSAAIALRQIGIDTEVYERVTENKPVGAAIS
MUL_0460|M.ulcerans_Agy99 ------MKAVIIG-AGIGGMSAAIALRQIGIDTEVYERVTENKPVGAAIS
Mb0590c|M.bovis_AF2122/97 ------MK-VAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYMID
Rv1260|M.tuberculosis_H37Rv ------MKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLRPGGQAID
MAV_4429|M.avium_104 MVGDARPLRVLVVGAGVAGISVARGLLRDGHDVTVFERRPRLAAAGGAVT
TH_1880|M.thermoresistible__bu ------VYDVIVVGGGPTGMMLAGELRLHGVRVLVVEKNSEPPAHVRSLG
MLBr_02276|M.leprae_Br4923 -MRVETSADVVVVGAGPAGSAAATWAARAGNDVIVIDSVCFPRDKACGDG
: .. * * * : :
Mflv_2621|M.gilvum_PYR-GCK LWPNALAALDQIGLGDSVRDAGGR----VTAGAIRWRDGTWVRRPSVRRI
Mvan_3960|M.vanbaalenii_PYR-1 IWPNALAALDQIGLGDNVRQAGGR----VTAGAIRWRDGTWLRRPSAQRI
MSMEG_4641|M.smegmatis_MC2_155 IWPNALAALDAIGLGDPVRAAGGR----VTAGALRWHDGTWLRHPAAERI
MAB_1601c|M.abscessus_ATCC_199 LWPNALAACDALGIGEDVRAASAR----VEAGTMRWYDGRILREPPSGKF
MMAR_4944|M.marinum_M VWSNGVKCLNYLGLEQQTARLGG---IVETMSYAEAHSGETMCRISMQPL
MUL_0460|M.ulcerans_Agy99 VWSNGVKCLNYLGLDQQTARLGG---IVETMSYAEAHSGETMCRISMQPL
Mb0590c|M.bovis_AF2122/97 FWGVGYQVAKRMGITDQIAAAGYHMEHVRSVGPTGKVKADLGVDVFRRMV
Rv1260|M.tuberculosis_H37Rv VRGPALDVLERMGL---LAAAQEHKTRIRGASFVDRDGNELFRDTESTPT
MAV_4429|M.avium_104 VWSNGETVLRQLGVEMDGAGRQLS-----SVGAVTS-TGRPLATLDVTAM
TH_1880|M.thermoresistible__bu LHVRSIEMLDQRGLLDRFLAHGQR-------HPVGGFFAAIAKPPAELDT
MLBr_02276|M.leprae_Br4923 LTPRAVAELKRLGLDDWLNTRIRHR------GLRMSGFGGEVEVDWPGPS
. . *:
Mflv_2621|M.gilvum_PYR-GCK VDALGEPLVVVRRSRLTDILREALP-AGTVRTGLAATRVSVGASSVRITL
Mvan_3960|M.vanbaalenii_PYR-1 VHALGEPLVVVRRSALTEILLDALP-PDTVQTGLSATALSIAAATARVTL
MSMEG_4641|M.smegmatis_MC2_155 TRALGEPLVVIRRRVLTEILSGALA-PGTVVHGLEAHTVETCASGIRVTF
MAB_1601c|M.abscessus_ATCC_199 TEAVGEPVAVTDRNQLLAILANRLT-PGTVRYGARVSNVRDGLHGTSVEL
MMAR_4944|M.marinum_M IEQVGQRPYPIARAELQQMLMEAYG-IDEIHFGMKMVEVANRDGAATATF
MUL_0460|M.ulcerans_Agy99 IEQVGQRPYPIARAELQQMLMEAYG-IDDIHFGMKMVEVANQDGAATATF
Mb0590c|M.bovis_AF2122/97 GDDFTS----LPRGDLAAAIYTTIEDQVETIFDDSIATIDEHRDGVRLTF
Rv1260|M.tuberculosis_H37Rv GGPVNSPDIELLRDDLVELLYGATQPSVEYLFDDSISTLQDDGDSVRVTF
MAV_4429|M.avium_104 ARRLGAPVRMVPRRVLLERLLDGFP-TGRIHCDRRAVALATSRDGVSVEF
TH_1880|M.thermoresistible__bu AHGYVLGIRQPVTDRLLAEWAAERG--AVIRRGCAVVGLDQDAAGITVEL
MLBr_02276|M.leprae_Br4923 FPSTSSAVPRLELDDRIRKVAENSGARMLLGTKAVSVYHDSSRRAASVTL
:
Mflv_2621|M.gilvum_PYR-GCK SDGEVRESDAVVGADGVNSVLARTLNG-PLRTRYVGYTAWRGIAAHPLDP
Mvan_3960|M.vanbaalenii_PYR-1 SDGRTREADAVVGADGVNSMVARALNG-PLPSRYVGYTAWRGVAAYRLDP
MSMEG_4641|M.smegmatis_MC2_155 SDGSVREASAVVGADGVDSVVARHLNG-PLRRRYAGYTAWRGIAAHPLDP
MAB_1601c|M.abscessus_ATCC_199 ADGQSLTAAAVIGADGIGSLVAQYLNG-PLAFRYSGYTAWRGIADISIPD
MMAR_4944|M.marinum_M ADGTIASADILIGADGANSITREYVLGGPVTRRYAGYVNYNGLVEVDEAI
MUL_0460|M.ulcerans_Agy99 TDGTIASADILIGADGANSITREYVLGGPVTRRYAGYVNYNGLVEVDEAI
Mb0590c|M.bovis_AF2122/97 ERTAPRDFDLVIGADGLHSNVRRLVFG--PERDFEHYLGCKVAACVVDGY
Rv1260|M.tuberculosis_H37Rv ERAAAREFDLVIGADGLHSNVRRLVFG--PEEQFVKRLGTHAAIFTVPNF
MAV_4429|M.avium_104 TDGTVAEGDVLIGADGLHSMVREWVGA--RHAKATGWCSWQGLVSLPEIA
TH_1880|M.thermoresistible__bu ADGSVQRARYLVGCDGGRSTVR-KLAGIGFPGEPARSETLLGEMSLSADP
MLBr_02276|M.leprae_Br4923 ADGTEVGCRQLIIADGARSPLGRKLGR-SWHQKTVYGVAARGYLTTPRSD
:: .** * :
Mflv_2621|M.gilvum_PYR-GCK ELGGETLGPGTQVG---------HVPLGPDHTYWFATERTAEGGSAPGGE
Mvan_3960|M.vanbaalenii_PYR-1 ALAGETMSAGTEVG---------HVPLGPDHTYWFATERTREGSRSAGGE
MSMEG_4641|M.smegmatis_MC2_155 ELSGETMGAGVEVG---------HVPLGADHTYWFATERASQGQRSPDGE
MAB_1601c|M.abscessus_ATCC_199 ELAGLTVGPGIEFG---------HLPLSLGRTYWFAGERSLEAQRAPDGE
MMAR_4944|M.marinum_M SPANEWTMYVGDGK----RVSAMPVADDR-FYFFFDVVEPEGLPFEKGTA
MUL_0460|M.ulcerans_Agy99 SPANEWTMYVGDGK----RVSAMPPTTPRPASGRADARRWKTRWHCNGRS
Mb0590c|M.bovis_AF2122/97 RPRDERSYVLYNT-----VDRQLARFALRGDRTMFLFVFRAEHDNPGVAP
Rv1260|M.tuberculosis_H37Rv LELDYWQTWHYGDSTMAGVYSARNNTEARAALAFMDTELRIDYRDT-EAQ
MAV_4429|M.avium_104 ESDAALMMIGGSGN-------LGLWPAGGAEVQWWFDLPWSTGFVRPQHP
TH_1880|M.thermoresistible__bu ATVAAVVAEVRKTQLR------FGAMPLGDGVYRVIVPAEGVAGDRAEPT
MLBr_02276|M.leprae_Br4923 DLWLTSHLELRSPD--------GAVLPGYGWIFPLGNGEVNIGVGALSTS
Mflv_2621|M.gilvum_PYR-GCK HA----YLTAKVADWADPIPRLVATTDPGDLLRNDLYDR-ARAARWSDGR
Mvan_3960|M.vanbaalenii_PYR-1 HA----YLTAKLAGWADPIPALLASTDPADVLRNDLYDR-AQPRDWSRGP
MSMEG_4641|M.smegmatis_MC2_155 LT----HLRRLFGSWAEPIPQLLAATDPADVLRNDLYDR-EPARCWARGP
MAB_1601c|M.abscessus_ATCC_199 IE----YLARKFGNWADPIPRLLRQSRESSVLRGDVYDR-GRLRRVAGGR
MMAR_4944|M.marinum_M RE----VLREQFAGWAPGVQALIDKLDPTTTNRVEILDL-DPFHTWVKGR
MUL_0460|M.ulcerans_Agy99 RT----TPPTLRPRWPP--------IRPAAPNGPAIWYC-GPVS------
Mb0590c|M.bovis_AF2122/97 KD----ELRDQFGDVGWESRDILAALDDVEDLYFDVVSQ-IRMDRWSRGR
Rv1260|M.tuberculosis_H37Rv FA----ELQRRMAEDGWVRAQLLHYMRSAPDFYFDEMSQ-ILMDRWSRGR
MAV_4429|M.avium_104 IE----TIRSHFAGWSEPVDRVLAILTDEDLAASPFPHFRHPIPPPGRGR
TH_1880|M.thermoresistible__bu LD----EFRRRLKAFAG-----TDFGAHTPRWLSRFGDATRLAERYRAGR
MLBr_02276|M.leprae_Br4923 KRPADLALRSLISYYTDLRRHEWGFSGQPRAVSSALLPMGGAVSGVAGPN
Mflv_2621|M.gilvum_PYR-GCK AVLIGDAAHPMRPHLGQGGCQGIEDAAILARFLELA-DDVPTA--FERFE
Mvan_3960|M.vanbaalenii_PYR-1 AVIVGDAAHPMRPHLGQGGCQGLEDAAILARFVGLS-PDLPAA--FDRFG
MSMEG_4641|M.smegmatis_MC2_155 VVLAGDAAHPMRPHLGQGGCQGLEDAATLAALVARE-PDLPTA--FARFA
MAB_1601c|M.abscessus_ATCC_199 VVLVGDAAHPMRPHLGQGGCQSLEDAAVLSVAISER-SSLPSA--FREYA
MMAR_4944|M.marinum_M VAVLGDAAHNTTPDIGQGGCSAMEDAVALQWALKDNPTDVAAA--LAAYQ
MUL_0460|M.ulcerans_Agy99 ------AATSSTPRTPIPPQPGMR-----SCETNTAPTSFAGS--SPTSW
Mb0590c|M.bovis_AF2122/97 VLLIGDAAGCISLLGGEGTGLAITEAYVLAGELARAGGDHRRA--FDAYE
Rv1260|M.tuberculosis_H37Rv VALVGDAGYCCSPLSGQGTSVALLGAYILAGELKAAGDDYQLG--FANYH
MAV_4429|M.avium_104 VTLLGDAAHTMPPTLAQGTNQALLDTMVLCQALADFGRGTPGG--QADVA
TH_1880|M.thermoresistible__bu VFLAGDAAHVHPPAGGQGLNLGIQDAFNLGWKLAAAVGGWAPDGLLDTYH
MLBr_02276|M.leprae_Br4923 WMLIGDAAACVNPLNGEGIDYGLETGRLAAELLDLRDLSYVWP----SLL
*. .: .
Mflv_2621|M.gilvum_PYR-GCK AFRKPRVGMLVREAQTLGRIVNVRPAVLSGLAGRATALIPERMVTAHLAW
Mvan_3960|M.vanbaalenii_PYR-1 AFRRRRVRPLVRESAAIGRIVNLRPAFLSGVASRASALIPEWAVASHLAS
MSMEG_4641|M.smegmatis_MC2_155 TLRRRRVTRMVRTSRMIGRIVNLRPAVLSAAASRATVLVPEAVLTRQLAS
MAB_1601c|M.abscessus_ATCC_199 RRRRSRTRAVVSRSRHIGNVTFARPAVVGGLLTRASARIPASVFWRQLSS
MMAR_4944|M.marinum_M ASRTERAGDLVLRARKRCDVIHAKDPDTTAAWYEELRNEDGTNIIRGLVA
MUL_0460|M.ulcerans_Agy99 VGRSLR--------------------------------------------
Mb0590c|M.bovis_AF2122/97 KRLRPFIEGKQASAAKFIWFFRHPNPIRPVVSQRCDAHDELRPAGDAVRR
Rv1260|M.tuberculosis_H37Rv AEFHGFVERNQ-------WLVSDNIPGGAPIPQ-----EEFERIVHSITI
MAV_4429|M.avium_104 NALRWYEKTRRRRVRAVSWVASLPVSHGEAVLRPAALVSDRLQAAALTMF
TH_1880|M.thermoresistible__bu AERHPVAADVLNNTRAQMELMSPEPGPRAVRWLLAELMDFEEVNRYLTEK
MLBr_02276|M.leprae_Br4923 QQHYGRGFSVARRLALLLTFKRCLPAIGPSAMRSTSLITIAVRVMANLVT
Mflv_2621|M.gilvum_PYR-GCK IAAGSAFVLPTAADLAR---------------------------------
Mvan_3960|M.vanbaalenii_PYR-1 IAAGSAFILPTAGDVGG---------------------------------
MSMEG_4641|M.smegmatis_MC2_155 IAARSAFTPVD---------------------------------------
MAB_1601c|M.abscessus_ATCC_199 IAGYEAGNLAVRP-------------------------------------
MMAR_4944|M.marinum_M NIMGGPLTPLS---------------------------------------
MUL_0460|M.ulcerans_Agy99 --------------------------------------------------
Mb0590c|M.bovis_AF2122/97 QRA-----------------------------------------------
Rv1260|M.tuberculosis_H37Rv KDY-----------------------------------------------
MAV_4429|M.avium_104 LRWTSHRRMSDHINRSVGEAINRSLGEAPKIPSRR---------------
TH_1880|M.thermoresistible__bu ITAIGVRYHTMGDGHGLLGRRMRDIPLTGGRLYARMHAGRGVLLDRTGTL
MLBr_02276|M.leprae_Br4923 DDDADWVARVWRSGGWASWLVDRRPPFS----------------------
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3960|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4641|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1601c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4944|M.marinum_M --------------------------------------------------
MUL_0460|M.ulcerans_Agy99 --------------------------------------------------
Mb0590c|M.bovis_AF2122/97 --------------------------------------------------
Rv1260|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4429|M.avium_104 --------------------------------------------------
TH_1880|M.thermoresistible__bu SVSGWADRVDHIVDPGAALDVPAVLLRPDGHVAWVGADHPGQQDLTARLS
MLBr_02276|M.leprae_Br4923 --------------------------------------------------
Mflv_2621|M.gilvum_PYR-GCK -------
Mvan_3960|M.vanbaalenii_PYR-1 -------
MSMEG_4641|M.smegmatis_MC2_155 -------
MAB_1601c|M.abscessus_ATCC_199 -------
MMAR_4944|M.marinum_M -------
MUL_0460|M.ulcerans_Agy99 -------
Mb0590c|M.bovis_AF2122/97 -------
Rv1260|M.tuberculosis_H37Rv -------
MAV_4429|M.avium_104 -------
TH_1880|M.thermoresistible__bu RWFGAPA
MLBr_02276|M.leprae_Br4923 -------