For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
AKPIVLISGAGIAGPALAFWLTHSGYQVVVTELADDIRPGGQTVDLRGAGRLVIERMGLLEQMRQRSLRQ RGIAWIRADGRRRAEMPVEAFHGNGPVSELEILRGDLAAVLYRATAAGTDYRFGTRITDLAPSGDAVQAR LSDGTTVRADLVVGADGPHSGVRRLAFGPEEQFARPLGGYNAWFSAPDTVGLNGWYLMYQAPGGLNASMR PSHDPATAKAGLAFRSAPIRYDRGDLDAQRDLLAACFAGAGWQSDALIAAAREADDFYLDAIVQIHLDAW SRGRVTLVGDAGYCASPLSGMGTSLALVGAYVLAGELGPAHGDGIDEAALAAALARYETVLRPYVANCQD LPNSIDRFLPMSESEIRSNAAAMKYMQRWPFRFFAERKWFTIAESIELPRYPRLP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1770 | - | - | 100% (406) | oxidoreductase |
| M. ulcerans Agy99 | MUL_4482 | - | 6e-61 | 40.19% (321) | hypothetical protein MUL_4482 |
| M. ulcerans Agy99 | MUL_0294 | - | 1e-50 | 37.57% (338) | membrane-associated oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0590c | - | 7e-45 | 34.94% (352) | hypothetical protein Mb0590c |
| M. gilvum PYR-GCK | Mflv_2621 | - | 3e-13 | 27.53% (356) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv1260 | - | 4e-67 | 43.61% (321) | hypothetical protein Rv1260 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0649c | - | 9e-71 | 38.06% (402) | putative monooxygenase |
| M. marinum M | MMAR_2185 | - | 0.0 | 99.75% (406) | oxidoreductase |
| M. avium 104 | MAV_1408 | - | 6e-67 | 42.98% (349) | hypothetical protein MAV_1408 |
| M. smegmatis MC2 155 | MSMEG_3039 | - | 1e-152 | 67.25% (403) | monooxygenase |
| M. thermoresistible (build 8) | TH_4641 | - | 5e-08 | 24.78% (339) | PUTATIVE oxygenase |
| M. vanbaalenii PYR-1 | Mvan_5278 | - | 5e-16 | 26.59% (346) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_1770|M.ulcerans_Agy99 ---MAKPIVLISGAGIAGPALAFWLTHSGYQVVVTELADDIRPGGQTVDL
MMAR_2185|M.marinum_M ---MAKPIVLISGAGIAGPALAFWLTHSGYQVVVTELADDIRPGGQTVDL
MSMEG_3039|M.smegmatis_MC2_155 ---MGQPTVLISGAGVAGTSLAHWLTEYGYRAVVVETAPTLRLGGQTVDL
MAB_0649c|M.abscessus_ATCC_199 ---MSR-EILISGGGIAGPALAYWLVQEGHSVTIVERAATVRNGGQAVDF
Rv1260|M.tuberculosis_H37Rv -----MKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLRPGGQAIDV
MAV_1408|M.avium_104 -----MSDVLVSGASVAGTAAAFWLGRHGHSVTVVERHRGPRPGGQAIDV
Mb0590c|M.bovis_AF2122/97 ------MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYMIDF
Mflv_2621|M.gilvum_PYR-GCK ----MSARISVIGAGISGLAAAVALERAGHHVSVIEQRTDTG-AGSGISL
Mvan_5278|M.vanbaalenii_PYR-1 ------MKVVIVGAGMGGMSAAIALRQIGIDTVVYERVTENKPVGAAISV
TH_4641|M.thermoresistible__bu MARETTTDVVVVGAGPVGLAVACGLLAHGLDVRVIDKAPAPATTSRANFL
: : *.. * : * * * : : . .
MUL_1770|M.ulcerans_Agy99 RGAGRLVIERMGLLEQMRQRSLRQRGIAWIR-ADGRRRAEMPVEA----F
MMAR_2185|M.marinum_M RGAGRLVIERMGLLEQMRQRSLRQRGIAWIR-ADGRRRAEMPVEA----F
MSMEG_3039|M.smegmatis_MC2_155 RGAGRDVVTRMGLLDEMRARSLDQRGIAWVR-GNGRRRAEMPVDA----F
MAB_0649c|M.abscessus_ATCC_199 RGPSIDVLDKMGVLDAVRAQATHMGSLVMVD-ADGKEIARFPSEV----I
Rv1260|M.tuberculosis_H37Rv RGPALDVLERMGLLAAAQEHKTRIRGASFVD-RDGNELFRDTES---TPT
MAV_1408|M.avium_104 RGPALGVLERMGLLAAAAKRRTQIRGSSVVD-RDGNELSRDTEAAISGPT
Mb0590c|M.bovis_AF2122/97 WGVGYQVAKRMGITDQIAAAGYHMEHVRSVG-PTGKVKADLGVDV----F
Mflv_2621|M.gilvum_PYR-GCK WPNALAALDQIGLGDSVRDAGGRVTAGAIRW-RDGTWVRRPSVRR----I
Mvan_5278|M.vanbaalenii_PYR-1 WSNGVKCLNYLGLQEETAELGGKVETMSYVDGHTGDTMCRFSMHP----L
TH_4641|M.thermoresistible__bu HARGSEVLDRLGALGGLPER--SVRAMQITTHLGGEPVMRMQFGD----P
. :* *
MUL_1770|M.ulcerans_Agy99 HGNGPVSELEILRGDLAAVLYRAT-AAGTDYRFGTRITDLAPSGDAVQAR
MMAR_2185|M.marinum_M HGNGPVSELEILRGDLAAVLYRAT-AAGTDYRFGTRITDLAPSGDAVQAR
MSMEG_3039|M.smegmatis_MC2_155 DGNGMVSALEILRGDLVEVLYNAT-SARAEYRFGTRITEIDSSG----AT
MAB_0649c|M.abscessus_ATCC_199 SG-----ELEILWGDLARILHEAV-REHVVFRFADSITGVRDDGAKVTVS
Rv1260|M.tuberculosis_H37Rv GGPVNSPDIELLRDDLVELLYGAT-QPSVEYLFDDSISTLQDDGDSVRVT
MAV_1408|M.avium_104 GGPIEGPDIELLRDDLVELLYGAS-QWTAEYLFDDTITALDDRGAAVRVS
Mb0590c|M.bovis_AF2122/97 RRMVGDDFTSLPRGDLAAAIYTTI-EDQVETIFDDSIATIDEHRDGVRLT
Mflv_2621|M.gilvum_PYR-GCK VDALGEPLVVVRRSRLTDILREAL-PAG-TVRTGLAATRVSVGASSVRIT
Mvan_5278|M.vanbaalenii_PYR-1 IEQVGQRPYPIARAELQLMLMKAYGIDDINFGMKMVGVENDTAGSAAKAT
TH_4641|M.thermoresistible__bu GMRTAAPPMVISQAEVEAALRNRLAELGGRVELDCPLTGLRQDASTVTAG
: : :
MUL_1770|M.ulcerans_Agy99 LSDGTTVRADLVVGADGPHSGVRR-LAFG-PEEQFARPLGGYNAWFSAPD
MMAR_2185|M.marinum_M LSDGTTVRADLVVGADGPHSGVRR-LAFG-PEEQFARPLGGYNAWFSAPD
MSMEG_3039|M.smegmatis_MC2_155 LSDGTRVDADLIVGADGPHSSVRR-MVFG-PEEQYVTLLGGYNAWFTAPD
MAB_0649c|M.abscessus_ATCC_199 FSRSAPESYDLLIGADGVHSGVRA-LTFG-PEHEFVTQLGQYFTFFAMDN
Rv1260|M.tuberculosis_H37Rv FERAAAREFDLVIGADGLHSNVRR-LVFG-PEEQFVKRLGTHAAIFTVPN
MAV_1408|M.avium_104 FERAAPRDFDLVIGADGLHSNVRR-LVFG-PEDEFIERLGTHAAIFTVPN
Mb0590c|M.bovis_AF2122/97 FERTAPRDFDLVIGADGLHSNVRR-LVFG-PERDFEHYLGCKVAACVVDG
Mflv_2621|M.gilvum_PYR-GCK LSDGEVRESDAVVGADGVNSVLAR-TLNG-PLRTRYVGYTAWRGIAAHPL
Mvan_5278|M.vanbaalenii_PYR-1 FADGTTVSADVIIGADGAGSITRE-YVLGGPVSRRYAGYVNYNGLVSTDD
TH_4641|M.thermoresistible__bu IGGGGELRGRWLVGCDGTGSSTRKSVGIGYPGARLSERFLLADVYLDWRL
: ::*.** * * *
MUL_1770|M.ulcerans_Agy99 TVGLNGWYLMYQAPGGLNASMRPSHDPATAKAGLAFRSAPIRYDRGDLDA
MMAR_2185|M.marinum_M TVGLNGWYLMYQAPGGLNASMRPSHDPATAKAGLAFRSAPIRYDRGDLDA
MSMEG_3039|M.smegmatis_MC2_155 TAGLDGWYLMYQVPG-LNASMRPSHDPALCKAGLAFRSGPVDYDRRDPAT
MAB_0649c|M.abscessus_ATCC_199 HLGLDHQTVGFREGT-RGVGIQATAPDAPARGSLSFSDDHLEFDYRDVEG
Rv1260|M.tuberculosis_H37Rv FLELDYWQTWHYGDS-TMAGVYSARNNTEARAALAFMDTELRIDYRDTEA
MAV_1408|M.avium_104 FLGLDYWQMWHYGDS-TMAGVYSARDNAEARAMLGFMDAELRLDYRDTEA
Mb0590c|M.bovis_AF2122/97 YRPRDERSYVLYNTVDRQLARFALRG----DRTMFLFVFRAEHDNPGVAP
Mflv_2621|M.gilvum_PYR-GCK DPELG--------GETLGPGTQVGHVPLGPDHTYWFATERTAEGGSAPGG
Mvan_5278|M.vanbaalenii_PYR-1 AIGPATEWTTYVGDGKRVSVMPVSDD----RFYFFFDVVEPQGSPYEEGR
TH_4641|M.thermoresistible__bu D---------RSGTTGWIHPDGMVGAMPMPDGLWRIIAYDPGPGDLDQGA
: .
MUL_1770|M.ulcerans_Agy99 QRDLLAACFAGAGWQSDALIAAAREADDFYLDAIVQIHLDAWSRGRVTLV
MMAR_2185|M.marinum_M QRDLLAARFAGAGWQSDALIAAAREADDFYLDAIVQIHLDAWSRGRVTLV
MSMEG_3039|M.smegmatis_MC2_155 QLALLNTHFAGAGWHCADLLAAAAVADDFYFDAFLQVHMPTLSRGPVTLV
MAB_0649c|M.abscessus_ATCC_199 NKKLFSERFTGFGWETPAVLRALSVTAEPYFDSLCQVHLDTYSRGRVCLL
Rv1260|M.tuberculosis_H37Rv QFAELQRRMAEDGWVRAQLLHYMRSAPDFYFDEMSQILMDRWSRGRVALV
MAV_1408|M.avium_104 QFAELERRMAGEGWVRPQLLEYMRTAPDFYFDEMSQIKMDRWSRGRVALV
Mb0590c|M.bovis_AF2122/97 K-DELRDQFGDVGWESRDILAALDDVEDLYFDVVSQIRMDRWSRGRVLLI
Mflv_2621|M.gilvum_PYR-GCK EHAYLTAKVADWADPIPRLVATTDPGDLLRNDLYDRARAARWSDGRAVLI
Mvan_5278|M.vanbaalenii_PYR-1 VREVLRAHFAGWTPGVQTLIDTLDPLATNRVEILDLDPFHTWVKGRVAVL
TH_4641|M.thermoresistible__bu LERLLYERTGHRVKVTGTVWQSEFR--------VHRRLADTYRRGRVFIA
: : * . :
MUL_1770|M.ulcerans_Agy99 GDAGYCASPLSGMGTSLALVGAYVLAGELGPAHGDGIDEAALAAALARYE
MMAR_2185|M.marinum_M GDAGYCASPLSGMGTSLALVGAYVLAGELGPAHGDGIDEAALAAALARYE
MSMEG_3039|M.smegmatis_MC2_155 GDAGYCASPLSGMGTSLALVGAYVLAGELGPA--DMFAHAKLGLALSRYE
MAB_0649c|M.abscessus_ATCC_199 GDAAWCASPRSGMGTSLAIVGAYVLAHELRSA------QGDFSIAFARFH
Rv1260|M.tuberculosis_H37Rv GDAGYCCSPLSGQGTSVALLGAYILAGELKAAG------DDYQLGFANYH
MAV_1408|M.avium_104 GDAGYCCSPLSGQGTSVALLGAYILAGELKAAG------EDHEAGFANYH
Mb0590c|M.bovis_AF2122/97 GDAAGCISLLGGEGTGLAITEAYVLAGELARAG------GDHRRAFDAYE
Mflv_2621|M.gilvum_PYR-GCK GDAAHPMRPHLGQGGCQGIEDAAILARFLELAD-------DVPTAFERFE
Mvan_5278|M.vanbaalenii_PYR-1 GDAAHNTTPDIGQGGCSAMEDAIALQWAFKDHP------DDVHAALAAYQ
TH_4641|M.thermoresistible__bu GDAAHAHAPFGGQGMLTGLGDAENLAFKLALVIRG----YAGPALLDTYE
***. * * .: * * : : :.
MUL_1770|M.ulcerans_Agy99 TVLRPYVANCQDLPNSIDRFLPMSESEIRSNAAAMKYMQRWP------FR
MMAR_2185|M.marinum_M TVLRPYVANCQDLPNSIDRFLPMSESEIRSNAAAMKYMQRWP------FR
MSMEG_3039|M.smegmatis_MC2_155 STMRPYIERCQDLPTGIDGYLPKSALDITIYTQVMKWMQRWP------IR
MAB_0649c|M.abscessus_ATCC_199 TLMAPYAARCQRLALDALKIGEADSPWATGLRRLGLWSLRLPG-----IR
Rv1260|M.tuberculosis_H37Rv AEFHGFVERNQWLVSDN---IPGGAP------------------------
MAV_1408|M.avium_104 REFADYVQRNQWLVVDN---IPGGAP------------------------
Mb0590c|M.bovis_AF2122/97 KRLRPFIEGKQASAAKFIWFFRHPNPIRPVVS----------------QR
Mflv_2621|M.gilvum_PYR-GCK AFRKPRVGMLVREAQTLGRIVNVRPAVLSGLAGRATALIPER-------M
Mvan_5278|M.vanbaalenii_PYR-1 SARTERAADLVLRARKRCDVTHAKDPQVTSRWYDELRNEDGT-------N
TH_4641|M.thermoresistible__bu AERRPLATEVLRNTSAATKLNIADRGVGRFLRDRVVLPLLALPSVQRRLT
MUL_1770|M.ulcerans_Agy99 FFAERKWFTIAESIELPRYPRLP---------------------------
MMAR_2185|M.marinum_M FFAERKWFTIAESIELPRYPRLP---------------------------
MSMEG_3039|M.smegmatis_MC2_155 SYAARKWFTTADAIQLPSYPAAQNKR------------------------
MAB_0649c|M.abscessus_ATCC_199 QLVARQALKVGRSFALPAYD------------------------------
Rv1260|M.tuberculosis_H37Rv -IPQEEFERIVHSITIKDY-------------------------------
MAV_1408|M.avium_104 -IPQEVFERIVASITLKDY-------------------------------
Mb0590c|M.bovis_AF2122/97 CDAHDELRPAGDAVRRQRA-------------------------------
Mflv_2621|M.gilvum_PYR-GCK VTAHLAWIAAGSAFVLPTAADLAR--------------------------
Mvan_5278|M.vanbaalenii_PYR-1 IIRGIVGNIVGGPLTPVTAATEG---------------------------
TH_4641|M.thermoresistible__bu YQTSQLWVTYRGGPLAPRTVSMTTPRPGDRVPDQRCVRDDGHISRLYEQL
MUL_1770|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2185|M.marinum_M --------------------------------------------------
MSMEG_3039|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0649c|M.abscessus_ATCC_199 --------------------------------------------------
Rv1260|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1408|M.avium_104 --------------------------------------------------
Mb0590c|M.bovis_AF2122/97 --------------------------------------------------
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5278|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4641|M.thermoresistible__bu GGRWAVLEPGSGRHHREGPGLLGTAHTFLGEYVVGLRGAEMRGCDAFLVR
MUL_1770|M.ulcerans_Agy99 -----------------------------
MMAR_2185|M.marinum_M -----------------------------
MSMEG_3039|M.smegmatis_MC2_155 -----------------------------
MAB_0649c|M.abscessus_ATCC_199 -----------------------------
Rv1260|M.tuberculosis_H37Rv -----------------------------
MAV_1408|M.avium_104 -----------------------------
Mb0590c|M.bovis_AF2122/97 -----------------------------
Mflv_2621|M.gilvum_PYR-GCK -----------------------------
Mvan_5278|M.vanbaalenii_PYR-1 -----------------------------
TH_4641|M.thermoresistible__bu PDGHLAWRGRDATDLADWLKSALTVGRVR