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MPAHTIVIGAGIAGLATAVALRRVGHDVTVIEQRTDLTSGAGISIWPNALAALDQIGLGDNVRQAGGRVT AGAIRWRDGTWLRRPSAQRIVHALGEPLVVVRRSALTEILLDALPPDTVQTGLSATALSIAAATARVTLS DGRTREADAVVGADGVNSMVARALNGPLPSRYVGYTAWRGVAAYRLDPALAGETMSAGTEVGHVPLGPDH TYWFATERTREGSRSAGGEHAYLTAKLAGWADPIPALLASTDPADVLRNDLYDRAQPRDWSRGPAVIVGD AAHPMRPHLGQGGCQGLEDAAILARFVGLSPDLPAAFDRFGAFRRRRVRPLVRESAAIGRIVNLRPAFLS GVASRASALIPEWAVASHLASIAAGSAFILPTAGDVGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3960 | - | - | 100% (388) | monooxygenase, FAD-binding |
| M. vanbaalenii PYR-1 | Mvan_5278 | - | 4e-40 | 30.86% (337) | monooxygenase, FAD-binding |
| M. vanbaalenii PYR-1 | Mvan_0442 | - | 7e-11 | 26.86% (376) | hypothetical protein Mvan_0442 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0590c | - | 4e-12 | 25.15% (342) | hypothetical protein Mb0590c |
| M. gilvum PYR-GCK | Mflv_2621 | - | 1e-165 | 73.06% (386) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv1260 | - | 7e-15 | 28.03% (314) | hypothetical protein Rv1260 |
| M. leprae Br4923 | MLBr_02276 | - | 6e-06 | 27.46% (193) | putative FAD-linked oxidoreductase |
| M. abscessus ATCC 19977 | MAB_1601c | - | 6e-98 | 47.66% (384) | putative monooxygenase |
| M. marinum M | MMAR_4944 | - | 2e-41 | 31.75% (337) | oxidoreductase |
| M. avium 104 | MAV_4556 | - | 5e-32 | 72.09% (86) | monooxygenase |
| M. smegmatis MC2 155 | MSMEG_4641 | - | 1e-145 | 68.78% (378) | salicylate hydroxylase |
| M. thermoresistible (build 8) | TH_1880 | - | 7e-08 | 26.77% (325) | flavin-type hydroxylase |
| M. ulcerans Agy99 | MUL_0460 | - | 1e-23 | 32.96% (179) | hypothetical protein MUL_0460 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3960|M.vanbaalenii_PYR-1 -----------MPAHTIVIGAGIAGLATAVALRRVGHDVTVIEQRTD-LT
Mflv_2621|M.gilvum_PYR-GCK -----------MSARISVIGAGISGLAAAVALERAGHHVSVIEQRTD-TG
MSMEG_4641|M.smegmatis_MC2_155 -----------MAASFLVVGAGITGLATAAALQRRGHDVCVAEARAD-TA
MAV_4556|M.avium_104 MPAPCGVRFDTMAQRILVIGAGIAGLATAVAMQRRGYAVTVVKERTD-TS
MAB_1601c|M.abscessus_ATCC_199 -----------MSDHIVVVGAGIAGLATAVAIQQSGRDVVVVDDRDG-TS
MMAR_4944|M.marinum_M -------------MKAVIIGAGIGGMSAAIALRQIGIDTEVYERVTENKP
MUL_0460|M.ulcerans_Agy99 -------------MKAVIIGAGIGGMSAAIALRQIGIDTEVYERVTENKP
Mb0590c|M.bovis_AF2122/97 ------------MK-VAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRT
Rv1260|M.tuberculosis_H37Rv ------------MKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLRP
MLBr_02276|M.leprae_Br4923 -------MRVETSADVVVVGAGPAGSAAATWAARAGNDVIVIDSVCFPRD
TH_1880|M.thermoresistible__bu ------------VYDVIVVGGGPTGMMLAGELRLHGVRVLVVEKNSEPPA
: *.. * * * : .
Mvan_3960|M.vanbaalenii_PYR-1 SGAGISIWPNALAALDQIGLGDNVRQAGGRVTAG----AIRWRDGTWLRR
Mflv_2621|M.gilvum_PYR-GCK AGSGISLWPNALAALDQIGLGDSVRDAGGRVTAG----AIRWRDGTWVRR
MSMEG_4641|M.smegmatis_MC2_155 SGAGISIWPNALAALDAIGLGDPVRAAGGRVTAG----ALRWHDGTWLRH
MAV_4556|M.avium_104 SGAGISIWPNALAALDRIGVGQAVRDAGGRITAG----ALRWRDGSWLRR
MAB_1601c|M.abscessus_ATCC_199 AGYAITLWPNALAACDALGIGEDVRAASARVEAG----TMRWYDGRILRE
MMAR_4944|M.marinum_M VGAAISVWSNGVKCLNYLGLEQQTARLGGIVETMS---YAEAHSGETMCR
MUL_0460|M.ulcerans_Agy99 VGAAISVWSNGVKCLNYLGLDQQTARLGGIVETMS---YAEAHSGETMCR
Mb0590c|M.bovis_AF2122/97 GGYMIDFWGVGYQVAKRMGITDQIAAAGYHMEHVRSVGPTGKVKADLGVD
Rv1260|M.tuberculosis_H37Rv GGQAIDVRGPALDVLERMGL---LAAAQEHKTRIRGASFVDRDGNELFRD
MLBr_02276|M.leprae_Br4923 KACGDGLTPRAVAELKRLGLDDWLNTRIRHRGLR-----MSGFGGEVEVD
TH_1880|M.thermoresistible__bu HVRSLGLHVRSIEMLDQRGLLDRFLAHGQRHPVG---------GFFAAIA
. . . *:
Mvan_3960|M.vanbaalenii_PYR-1 PSAQRIVHALGEPLVVVRRSALTEILLDALPPDTVQ-TGLSATALSIAAA
Mflv_2621|M.gilvum_PYR-GCK PSVRRIVDALGEPLVVVRRSRLTDILREALPAGTVR-TGLAATRVSVGAS
MSMEG_4641|M.smegmatis_MC2_155 PAAERITRALGEPLVVIRRRVLTEILSGALAPGTVV-HGLEAHTVETCAS
MAV_4556|M.avium_104 PAFT-------------------------LPKG-----------------
MAB_1601c|M.abscessus_ATCC_199 PPSGKFTEAVGEPVAVTDRNQLLAILANRLTPGTVR-YGARVSNVRDGLH
MMAR_4944|M.marinum_M ISMQPLIEQVGQRPYPIARAELQQMLMEAYGIDEIH-FGMKMVEVANRDG
MUL_0460|M.ulcerans_Agy99 ISMQPLIEQVGQRPYPIARAELQQMLMEAYGIDDIH-FGMKMVEVANQDG
Mb0590c|M.bovis_AF2122/97 VFRRMVGDDFTS----LPRGDLAAAIYTTIEDQVETIFDDSIATIDEHRD
Rv1260|M.tuberculosis_H37Rv TESTPTGGPVNSPDIELLRDDLVELLYGATQPSVEYLFDDSISTLQDDGD
MLBr_02276|M.leprae_Br4923 WPGPSFPSTSSAVPRLELDDRIRKVAENSGARMLLG-TKAVSVYHDSSRR
TH_1880|M.thermoresistible__bu KPPAELDTAHGYVLGIRQPVTDRLLAEWAAERGAVIRRGCAVVGLDQDAA
Mvan_3960|M.vanbaalenii_PYR-1 TARVTLSDGRTREADAVVGADGVNSMVARALNG---PLPSRYVGYTAWRG
Mflv_2621|M.gilvum_PYR-GCK SVRITLSDGEVRESDAVVGADGVNSVLARTLNG---PLRTRYVGYTAWRG
MSMEG_4641|M.smegmatis_MC2_155 GIRVTFSDGSVREASAVVGADGVDSVVARHLNG---PLRRRYAGYTAWRG
MAV_4556|M.avium_104 --------------------------------------------------
MAB_1601c|M.abscessus_ATCC_199 GTSVELADGQSLTAAAVIGADGIGSLVAQYLNG---PLAFRYSGYTAWRG
MMAR_4944|M.marinum_M AATATFADGTIASADILIGADGANSITREYVLGG--PVTRRYAGYVNYNG
MUL_0460|M.ulcerans_Agy99 AATATFTDGTIASADILIGADGANSITREYVLGG--PVTRRYAGYVNYNG
Mb0590c|M.bovis_AF2122/97 GVRLTFERTAPRDFDLVIGADGLHSNVRRLVFGPERDFEHYLGCKVAACV
Rv1260|M.tuberculosis_H37Rv SVRVTFERAAAREFDLVIGADGLHSNVRRLVFGPEEQFVKRLGTHAAIFT
MLBr_02276|M.leprae_Br4923 AASVTLADGTEVGCRQLIIADGARSPLGRKLGR---SWHQKTVYGVAARG
TH_1880|M.thermoresistible__bu GITVELADGSVQRARYLVGCDGGRSTVRKLAGIG---FPGEPARSETLLG
Mvan_3960|M.vanbaalenii_PYR-1 VAAYRLDPALA---GETMSAGTEVGHVPLGPDH--TYWFATERTREGSRS
Mflv_2621|M.gilvum_PYR-GCK IAAHPLDPELG---GETLGPGTQVGHVPLGPDH--TYWFATERTAEGGSA
MSMEG_4641|M.smegmatis_MC2_155 IAAHPLDPELS---GETMGAGVEVGHVPLGADH--TYWFATERASQGQRS
MAV_4556|M.avium_104 --------------------------------------------------
MAB_1601c|M.abscessus_ATCC_199 IADISIPDELA---GLTVGPGIEFGHLPLSLGR--TYWFAGERSLEAQRA
MMAR_4944|M.marinum_M LVEVDEAISPANEWTMYVGDGKRVSAMPVADDR-FYFFFDVVEPEGLPFE
MUL_0460|M.ulcerans_Agy99 LVEVDEAISPANEWTMYVGDGKRVSAMPPTTPRPASGRADARRWKTRWHC
Mb0590c|M.bovis_AF2122/97 VDGYRPRDERSYVLYNT-----VDRQLARFALRGDRTMFLFVFRAEHDNP
Rv1260|M.tuberculosis_H37Rv VPNFLELDYWQTWHYGDSTMAGVYSARNNTEARAALAFMDTELRIDYRDT
MLBr_02276|M.leprae_Br4923 YLTTPRSDDLWLTSHLELRSPDGAVLPGYGWIFPLGNGEVNIGVGALSTS
TH_1880|M.thermoresistible__bu EMSLSADPATVAAVVAEVRKTQLRFGAMPLGDG--VYRVIVPAEGVAGDR
Mvan_3960|M.vanbaalenii_PYR-1 AGGEHAYLTAKLAGWADPIPALLASTDPADVLRNDLYDRA-QPRDWSRGP
Mflv_2621|M.gilvum_PYR-GCK PGGEHAYLTAKVADWADPIPRLVATTDPGDLLRNDLYDRA-RAARWSDGR
MSMEG_4641|M.smegmatis_MC2_155 PDGELTHLRRLFGSWAEPIPQLLAATDPADVLRNDLYDRE-PARCWARGP
MAV_4556|M.avium_104 --------------------------------------------------
MAB_1601c|M.abscessus_ATCC_199 PDGEIEYLARKFGNWADPIPRLLRQSRESSVLRGDVYDRG-RLRRVAGGR
MMAR_4944|M.marinum_M KGTAREVLREQFAGWAPGVQALIDKLDPTTTNRVEILDLD-PFHTWVKGR
MUL_0460|M.ulcerans_Agy99 NGRSRTTPPTLRPRWPP--------IRPAAPNGPAIWYCG-PVS------
Mb0590c|M.bovis_AF2122/97 GVAPKDELRDQFGDVGWESRDILAALDDVEDLYFDVVSQI-RMDRWSRGR
Rv1260|M.tuberculosis_H37Rv -EAQFAELQRRMAEDGWVRAQLLHYMRSAPDFYFDEMSQI-LMDRWSRGR
MLBr_02276|M.leprae_Br4923 KRPADLALRSLISYYTDLRRHEWGFSGQPRAVSSALLPMGGAVSGVAGPN
TH_1880|M.thermoresistible__bu AEPTLDEFRRRLKAFAG-----TDFGAHTPRWLSRFGDATRLAERYRAGR
Mvan_3960|M.vanbaalenii_PYR-1 AVIVGDAAHPMRPHLGQGGCQGLEDAAILARFVGLS-PDLPAA--FDRFG
Mflv_2621|M.gilvum_PYR-GCK AVLIGDAAHPMRPHLGQGGCQGIEDAAILARFLELA-DDVPTA--FERFE
MSMEG_4641|M.smegmatis_MC2_155 VVLAGDAAHPMRPHLGQGGCQGLEDAATLAALVARE-PDLPTA--FARFA
MAV_4556|M.avium_104 --------------------------------------------------
MAB_1601c|M.abscessus_ATCC_199 VVLVGDAAHPMRPHLGQGGCQSLEDAAVLSVAISER-SSLPSA--FREYA
MMAR_4944|M.marinum_M VAVLGDAAHNTTPDIGQGGCSAMEDAVALQWALKDNPTDVAAA--LAAYQ
MUL_0460|M.ulcerans_Agy99 ------AATSSTPRTPIPPQPGMR-----SCETNTAPTSFAGS--SPTSW
Mb0590c|M.bovis_AF2122/97 VLLIGDAAGCISLLGGEGTGLAITEAYVLAGELARAGGDHRRA--FDAYE
Rv1260|M.tuberculosis_H37Rv VALVGDAGYCCSPLSGQGTSVALLGAYILAGELKAAGDDYQLG--FANYH
MLBr_02276|M.leprae_Br4923 WMLIGDAAACVNPLNGEGIDYGLETGRLAAELLDLR--DLSYV--WPSLL
TH_1880|M.thermoresistible__bu VFLAGDAAHVHPPAGGQGLNLGIQDAFNLGWKLAAAVGGWAPDGLLDTYH
Mvan_3960|M.vanbaalenii_PYR-1 AFRRRRVRPLVRESAAIGRIVNLRPAFLSGVASRASALIPEWAVASHLAS
Mflv_2621|M.gilvum_PYR-GCK AFRKPRVGMLVREAQTLGRIVNVRPAVLSGLAGRATALIPERMVTAHLAW
MSMEG_4641|M.smegmatis_MC2_155 TLRRRRVTRMVRTSRMIGRIVNLRPAVLSAAASRATVLVPEAVLTRQLAS
MAV_4556|M.avium_104 --------------------------------------------------
MAB_1601c|M.abscessus_ATCC_199 RRRRSRTRAVVSRSRHIGNVTFARPAVVGGLLTRASARIPASVFWRQLSS
MMAR_4944|M.marinum_M ASRTERAGDLVLRARKRCDVIHAKDPDTTAAWYEELRNEDGTNIIRGLVA
MUL_0460|M.ulcerans_Agy99 VGRSLR--------------------------------------------
Mb0590c|M.bovis_AF2122/97 KRLRPFIEGKQASAAKFIWFFRHPNPIRPVVSQRCDAHDELRPAGDAVRR
Rv1260|M.tuberculosis_H37Rv AEFHGFVERNQ-------WLVSDNIPGGAPIPQ-----EEFERIVHSITI
MLBr_02276|M.leprae_Br4923 QQHYGRGFSVARRLALLLTFKRCLPAIGPSAMRSTSLITIAVRVMANLVT
TH_1880|M.thermoresistible__bu AERHPVAADVLNNTRAQMELMSPEPGPRAVRWLLAELMDFEEVNRYLTEK
Mvan_3960|M.vanbaalenii_PYR-1 IAAGSAFILPTAGDVGG---------------------------------
Mflv_2621|M.gilvum_PYR-GCK IAAGSAFVLPTAADLAR---------------------------------
MSMEG_4641|M.smegmatis_MC2_155 IAARSAFTPVD---------------------------------------
MAV_4556|M.avium_104 --------------------------------------------------
MAB_1601c|M.abscessus_ATCC_199 IAGYEAGNLAVRP-------------------------------------
MMAR_4944|M.marinum_M NIMGGPLTPLS---------------------------------------
MUL_0460|M.ulcerans_Agy99 --------------------------------------------------
Mb0590c|M.bovis_AF2122/97 QRA-----------------------------------------------
Rv1260|M.tuberculosis_H37Rv KDY-----------------------------------------------
MLBr_02276|M.leprae_Br4923 DDDADWVARVWRSGGWASWLVDRRPPFS----------------------
TH_1880|M.thermoresistible__bu ITAIGVRYHTMGDGHGLLGRRMRDIPLTGGRLYARMHAGRGVLLDRTGTL
Mvan_3960|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4641|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4556|M.avium_104 --------------------------------------------------
MAB_1601c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4944|M.marinum_M --------------------------------------------------
MUL_0460|M.ulcerans_Agy99 --------------------------------------------------
Mb0590c|M.bovis_AF2122/97 --------------------------------------------------
Rv1260|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02276|M.leprae_Br4923 --------------------------------------------------
TH_1880|M.thermoresistible__bu SVSGWADRVDHIVDPGAALDVPAVLLRPDGHVAWVGADHPGQQDLTARLS
Mvan_3960|M.vanbaalenii_PYR-1 -------
Mflv_2621|M.gilvum_PYR-GCK -------
MSMEG_4641|M.smegmatis_MC2_155 -------
MAV_4556|M.avium_104 -------
MAB_1601c|M.abscessus_ATCC_199 -------
MMAR_4944|M.marinum_M -------
MUL_0460|M.ulcerans_Agy99 -------
Mb0590c|M.bovis_AF2122/97 -------
Rv1260|M.tuberculosis_H37Rv -------
MLBr_02276|M.leprae_Br4923 -------
TH_1880|M.thermoresistible__bu RWFGAPA