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VGDARPLRVLVVGAGVAGISVARGLLRDGHDVTVFERRPRLAAAGGAVTVWSNGETVLRQLGVEMDGAGR QLSSVGAVTSTGRPLATLDVTAMARRLGAPVRMVPRRVLLERLLDGFPTGRIHCDRRAVALATSRDGVSV EFTDGTVAEGDVLIGADGLHSMVREWVGARHAKATGWCSWQGLVSLPEIAESDAALMMIGGSGNLGLWPA GGAEVQWWFDLPWSTGFVRPQHPIETIRSHFAGWSEPVDRVLAILTDEDLAASPFPHFRHPIPPPGRGRV TLLGDAAHTMPPTLAQGTNQALLDTMVLCQALADFGRGTPGGQADVANALRWYEKTRRRRVRAVSWVASL PVSHGEAVLRPAALVSDRLQAAALTMFLRWTSHRRMSDHINRSVGEAINRSLGEAPKIPSRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4429 | - | - | 100% (413) | FAD binding domain-containing protein |
| M. avium 104 | MAV_1408 | - | 5e-13 | 28.31% (332) | hypothetical protein MAV_1408 |
| M. avium 104 | MAV_0984 | - | 2e-11 | 26.97% (419) | hypothetical protein MAV_0984 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0590c | - | 2e-18 | 28.03% (346) | hypothetical protein Mb0590c |
| M. gilvum PYR-GCK | Mflv_2621 | - | 7e-30 | 27.75% (382) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv0575c | - | 2e-18 | 28.03% (346) | hypothetical protein Rv0575c |
| M. leprae Br4923 | MLBr_02276 | - | 5e-05 | 27.27% (231) | putative FAD-linked oxidoreductase |
| M. abscessus ATCC 19977 | MAB_1601c | - | 2e-29 | 28.45% (341) | putative monooxygenase |
| M. marinum M | MMAR_4944 | - | 1e-34 | 29.41% (357) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_4641 | - | 5e-35 | 30.89% (369) | salicylate hydroxylase |
| M. thermoresistible (build 8) | TH_4641 | - | 2e-10 | 24.48% (335) | PUTATIVE oxygenase |
| M. ulcerans Agy99 | MUL_0460 | - | 8e-23 | 27.34% (289) | hypothetical protein MUL_0460 |
| M. vanbaalenii PYR-1 | Mvan_3960 | - | 6e-32 | 30.03% (373) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0590c|M.bovis_AF2122/97 -------MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYMID
Rv0575c|M.tuberculosis_H37Rv -------MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYMID
Mflv_2621|M.gilvum_PYR-GCK -----MSARISVIGAGISGLAAAVALERAGHHVSVIEQRTDTGAG-SGIS
Mvan_3960|M.vanbaalenii_PYR-1 -----MPAHTIVIGAGIAGLATAVALRRVGHDVTVIEQRTDLTSG-AGIS
MSMEG_4641|M.smegmatis_MC2_155 -----MAASFLVVGAGITGLATAAALQRRGHDVCVAEARADTASG-AGIS
MAB_1601c|M.abscessus_ATCC_199 -----MSDHIVVVGAGIAGLATAVAIQQSGRDVVVVDDRDGTSAG-YAIT
MMAR_4944|M.marinum_M -------MKAVIIGAGIGGMSAAIALRQIGIDTEVYERVTENKPVGAAIS
MUL_0460|M.ulcerans_Agy99 -------MKAVIIGAGIGGMSAAIALRQIGIDTEVYERVTENKPVGAAIS
MAV_4429|M.avium_104 MVGDARPLRVLVVGAGVAGISVARGLLRDGHDVTVFERRPRLAAAGGAVT
TH_4641|M.thermoresistible__bu -MARETTTDVVVVGAGPVGLAVACGLLAHGLDVRVIDKAPAPATTSRANF
MLBr_02276|M.leprae_Br4923 -MRVETSADVVVVGAGPAGSAAATWAARAGNDVIVIDSVCFPRDKACGDG
: *** * : * * * :
Mb0590c|M.bovis_AF2122/97 FWGVGYQVAKRMGITDQIAAAGYHMEHV-RSVGPTGKVKADLGVDVFRRM
Rv0575c|M.tuberculosis_H37Rv FWGVGYQVAKRMGITDQIAAAGYHMEHV-RSVGPTGKVKADLGVDVFRRM
Mflv_2621|M.gilvum_PYR-GCK LWPNALAALDQIGLGDSVRDAGGRVTAG-AIRWRDGTWVRRPSVRRIVDA
Mvan_3960|M.vanbaalenii_PYR-1 IWPNALAALDQIGLGDNVRQAGGRVTAG-AIRWRDGTWLRRPSAQRIVHA
MSMEG_4641|M.smegmatis_MC2_155 IWPNALAALDAIGLGDPVRAAGGRVTAG-ALRWHDGTWLRHPAAERITRA
MAB_1601c|M.abscessus_ATCC_199 LWPNALAACDALGIGEDVRAASARVEAG-TMRWYDGRILREPPSGKFTEA
MMAR_4944|M.marinum_M VWSNGVKCLNYLGLEQQTARLGGIVETMSYAEAHSGETMCRISMQPLIEQ
MUL_0460|M.ulcerans_Agy99 VWSNGVKCLNYLGLDQQTARLGGIVETMSYAEAHSGETMCRISMQPLIEQ
MAV_4429|M.avium_104 VWSNGETVLRQLGVEMDG---AGRQLSSVGAVTSTGRPLATLDVTAMARR
TH_4641|M.thermoresistible__bu LHARGSEVLDRLGALGGLPERSVRAMQI--TTHLGGEPVMRMQFGDPGMR
MLBr_02276|M.leprae_Br4923 LTPRAVAELKRLGLDDWLNTRIRHRGLR--MSGFGG----EVEVDWPGPS
. . :* *
Mb0590c|M.bovis_AF2122/97 VGDDFTSLPRGDLAAAIYTTIEDQV-ETIFDDSIATIDEHRD--GVRLTF
Rv0575c|M.tuberculosis_H37Rv VGDDFTSLPRGDLAAAIYTTIEDQV-ETIFDDSIATIDEHRD--GVRLTF
Mflv_2621|M.gilvum_PYR-GCK LGEPLVVVRRSRLTDILREALPAG--TVRTGLAATRVSVGAS--SVRITL
Mvan_3960|M.vanbaalenii_PYR-1 LGEPLVVVRRSALTEILLDALPPD--TVQTGLSATALSIAAA--TARVTL
MSMEG_4641|M.smegmatis_MC2_155 LGEPLVVIRRRVLTEILSGALAPG--TVVHGLEAHTVETCAS--GIRVTF
MAB_1601c|M.abscessus_ATCC_199 VGEPVAVTDRNQLLAILANRLTPG--TVRYGARVSNVRDGLH--GTSVEL
MMAR_4944|M.marinum_M VGQRPYPIARAELQQMLMEAYGID--EIHFGMKMVEVANRDG--AATATF
MUL_0460|M.ulcerans_Agy99 VGQRPYPIARAELQQMLMEAYGID--DIHFGMKMVEVANQDG--AATATF
MAV_4429|M.avium_104 LGAPVRMVPRRVLLERLLDGFPTG--RIHCDRRAVALATSRD--GVSVEF
TH_4641|M.thermoresistible__bu TAAPPMVISQAEVEAALRNRLAELGGRVELDCPLTGLRQDAS--TVTAGI
MLBr_02276|M.leprae_Br4923 FPSTSSAVPRLELDDRIRKVAENSGARMLLGTKAVSVYHDSSRRAASVTL
: : : . : :
Mb0590c|M.bovis_AF2122/97 ERTAPRDFDLVIGADGLHSNVRRLVFG-PERDFEHYLGCKVAACVVDGYR
Rv0575c|M.tuberculosis_H37Rv ERTAPRDFDLVIGADGLHSNVRRLVFG-PERDFEHYLGCKVAACVVDGYR
Mflv_2621|M.gilvum_PYR-GCK SDGEVRESDAVVGADGVNSVLARTLNG-PLR--TRYVGYTAWRGIAAHPL
Mvan_3960|M.vanbaalenii_PYR-1 SDGRTREADAVVGADGVNSMVARALNG-PLP--SRYVGYTAWRGVAAYRL
MSMEG_4641|M.smegmatis_MC2_155 SDGSVREASAVVGADGVDSVVARHLNG-PLR--RRYAGYTAWRGIAAHPL
MAB_1601c|M.abscessus_ATCC_199 ADGQSLTAAAVIGADGIGSLVAQYLNG-PLA--FRYSGYTAWRGIADISI
MMAR_4944|M.marinum_M ADGTIASADILIGADGANSITREYVLGGPVT--RRYAGYVNYNGLVEVDE
MUL_0460|M.ulcerans_Agy99 TDGTIASADILIGADGANSITREYVLGGPVT--RRYAGYVNYNGLVEVDE
MAV_4429|M.avium_104 TDGTVAEGDVLIGADGLHSMVREWVGARHAK----ATGWCSWQGLVSLPE
TH_4641|M.thermoresistible__bu GGGGELRGRWLVGCDGTGSSTRKSVGIGYPG-----ARLSERFLLADVYL
MLBr_02276|M.leprae_Br4923 ADGTEVGCRQLIIADGARSPLGRKLGRSWHQ--KTVYGVAARGYLTTPRS
:: .** * . : :.
Mb0590c|M.bovis_AF2122/97 PRDER--SYVLYNTVDRQLA----RFALRGDR--TMFLFVFR-AEHDNPG
Rv0575c|M.tuberculosis_H37Rv PRDER--SYVLYNTVDRQLA----RFALRGDR--TMFLFVFR-AEHDNPG
Mflv_2621|M.gilvum_PYR-GCK DPELG--GETLG--PGTQVG----HVPLGPDH--TYWFATERTAEGGSAP
Mvan_3960|M.vanbaalenii_PYR-1 DPALA--GETMS--AGTEVG----HVPLGPDH--TYWFATERTREGSRSA
MSMEG_4641|M.smegmatis_MC2_155 DPELS--GETMG--AGVEVG----HVPLGADH--TYWFATERASQGQRSP
MAB_1601c|M.abscessus_ATCC_199 PDELA--GLTVG--PGIEFG----HLPLSLGR--TYWFAGERSLEAQRAP
MMAR_4944|M.marinum_M AISPAN-EWTMYVGDGKRVS----AMPVADDR-FYFFFDVVEPEGLPFEK
MUL_0460|M.ulcerans_Agy99 AISPAN-EWTMYVGDGKRVS----AMPPTTPRPASGRADARRWKTRWHCN
MAV_4429|M.avium_104 IAESD--AALMMIGGSGNLG----LWPAGGAE--VQWWFDLPWSTGFVRP
TH_4641|M.thermoresistible__bu DWRLDRSGTTGWIHPDGMVG----AMPMPDGL---WRIIAYDPGPGDLDQ
MLBr_02276|M.leprae_Br4923 DDLWLTSHLELRSPDGAVLPGYGWIFPLGNGE------VNIGVGALSTSK
. . .
Mb0590c|M.bovis_AF2122/97 VAPKDELRDQFGDVGWESRDILAALDDVEDLYFDVVSQ-IRMDRWSRGRV
Rv0575c|M.tuberculosis_H37Rv VAPKDELRDQFGDVGWESRDILAALDDVEDLYFDVVSQ-IRMDRWSRGRV
Mflv_2621|M.gilvum_PYR-GCK GGEHAYLTAKVADWADPIPRLVATTDPGDLLRNDLYDR-ARAARWSDGRA
Mvan_3960|M.vanbaalenii_PYR-1 GGEHAYLTAKLAGWADPIPALLASTDPADVLRNDLYDR-AQPRDWSRGPA
MSMEG_4641|M.smegmatis_MC2_155 DGELTHLRRLFGSWAEPIPQLLAATDPADVLRNDLYDR-EPARCWARGPV
MAB_1601c|M.abscessus_ATCC_199 DGEIEYLARKFGNWADPIPRLLRQSRESSVLRGDVYDR-GRLRRVAGGRV
MMAR_4944|M.marinum_M GTAREVLREQFAGWAPGVQALIDKLDPTTTNRVEILDL-DPFHTWVKGRV
MUL_0460|M.ulcerans_Agy99 GRSRTTPPTLRPRWPP--------IRPAAPNGPAIWYC-GPVS-------
MAV_4429|M.avium_104 QHPIETIRSHFAGWSEPVDRVLAILTDEDLAASPFPHFRHPIPPPGRGRV
TH_4641|M.thermoresistible__bu GALERLLYERTGHRVKVTGTVWQSEFRVHRRLADTYRR---------GRV
MLBr_02276|M.leprae_Br4923 RPADLALRSLISYYTDLRRHEWGFSGQPRAVSSALLPMGGAVSGVAGPNW
Mb0590c|M.bovis_AF2122/97 LLIGDAAGCISLLGGEGTGLAITEAYVLAGELARAGG-------DHRRAF
Rv0575c|M.tuberculosis_H37Rv LLIGDAAGCISLLGGEGTGLAITEAYVLAGELARAGG-------DHRRAF
Mflv_2621|M.gilvum_PYR-GCK VLIGDAAHPMRPHLGQGGCQGIEDAAILARFLELAD--------DVPTAF
Mvan_3960|M.vanbaalenii_PYR-1 VIVGDAAHPMRPHLGQGGCQGLEDAAILARFVGLSP--------DLPAAF
MSMEG_4641|M.smegmatis_MC2_155 VLAGDAAHPMRPHLGQGGCQGLEDAATLAALVAREP--------DLPTAF
MAB_1601c|M.abscessus_ATCC_199 VLVGDAAHPMRPHLGQGGCQSLEDAAVLSVAISERS--------SLPSAF
MMAR_4944|M.marinum_M AVLGDAAHNTTPDIGQGGCSAMEDAVALQWALKDNPT-------DVAAAL
MUL_0460|M.ulcerans_Agy99 -----AATSSTPRTPIPPQPGMR-----SCETNTAPT-------SFAGSS
MAV_4429|M.avium_104 TLLGDAAHTMPPTLAQGTNQALLDTMVLCQALADFGRGTPGGQADVANAL
TH_4641|M.thermoresistible__bu FIAGDAAHAHAPFGGQGMLTGLGDAENLAFKLALVIRG-----YAGPALL
MLBr_02276|M.leprae_Br4923 MLIGDAAACVNPLNGEGIDYGLETGRLAAELLDLRDLSYVWPSLLQQHYG
** .:
Mb0590c|M.bovis_AF2122/97 DAYEKRLRPFIEGKQASA--------------AKFIWFFRHPN----PIR
Rv0575c|M.tuberculosis_H37Rv DAYEKRLRPFIEGKQASA--------------AKFIWFFATRTRFGLWFR
Mflv_2621|M.gilvum_PYR-GCK ERFEAFRKPRVGMLVREA--------------QTLGRIVNVRPAVLSGLA
Mvan_3960|M.vanbaalenii_PYR-1 DRFGAFRRRRVRPLVRES--------------AAIGRIVNLRPAFLSGVA
MSMEG_4641|M.smegmatis_MC2_155 ARFATLRRRRVTRMVRTS--------------RMIGRIVNLRPAVLSAAA
MAB_1601c|M.abscessus_ATCC_199 REYARRRRSRTRAVVSRS--------------RHIGNVTFARPAVVGGLL
MMAR_4944|M.marinum_M AAYQASRTERAGDLVLRA--------------RKRCDVIHAKDPDTTAAW
MUL_0460|M.ulcerans_Agy99 PTSWVGRSLR----------------------------------------
MAV_4429|M.avium_104 RWYEKTRRRRVRAVSWVASLP----------VSHGEAVLRPAALVSDRLQ
TH_4641|M.thermoresistible__bu DTYEAERRPLATEVLRNTSAATKLNIADRGVGRFLRDRVVLPLLALPSVQ
MLBr_02276|M.leprae_Br4923 RGFSVARRLALLLTFKRCLP------------AIGPSAMRSTSLITIAVR
Mb0590c|M.bovis_AF2122/97 PVVSQRCDAHDELRPAGDAVRRQRA-------------------------
Rv0575c|M.tuberculosis_H37Rv NVAMRTMNFGPLATLFAGSVRDDFELPDYTW-------------------
Mflv_2621|M.gilvum_PYR-GCK GRATALIPERMVTAHLAWIAAGSAFVLPTAADLAR---------------
Mvan_3960|M.vanbaalenii_PYR-1 SRASALIPEWAVASHLASIAAGSAFILPTAGDVGG---------------
MSMEG_4641|M.smegmatis_MC2_155 SRATVLVPEAVLTRQLASIAARSAFTPVD---------------------
MAB_1601c|M.abscessus_ATCC_199 TRASARIPASVFWRQLSSIAGYEAGNLAVRP-------------------
MMAR_4944|M.marinum_M YEELRNEDGTNIIRGLVANIMGGPLTPLS---------------------
MUL_0460|M.ulcerans_Agy99 --------------------------------------------------
MAV_4429|M.avium_104 AAALTMFLRWTSHRRMSDHINRSVGEAINRSLGEAPKIPSRR--------
TH_4641|M.thermoresistible__bu RRLTYQTSQLWVTYRGGPLAPRTVSMTTPRPGDRVPDQRCVRDDGHISRL
MLBr_02276|M.leprae_Br4923 VMANLVTDDDADWVARVWRSGGWASWLVDRRPPFS---------------
Mb0590c|M.bovis_AF2122/97 --------------------------------------------------
Rv0575c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3960|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4641|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1601c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4944|M.marinum_M --------------------------------------------------
MUL_0460|M.ulcerans_Agy99 --------------------------------------------------
MAV_4429|M.avium_104 --------------------------------------------------
TH_4641|M.thermoresistible__bu YEQLGGRWAVLEPGSGRHHREGPGLLGTAHTFLGEYVVGLRGAEMRGCDA
MLBr_02276|M.leprae_Br4923 --------------------------------------------------
Mb0590c|M.bovis_AF2122/97 ---------------------------------
Rv0575c|M.tuberculosis_H37Rv ---------------------------------
Mflv_2621|M.gilvum_PYR-GCK ---------------------------------
Mvan_3960|M.vanbaalenii_PYR-1 ---------------------------------
MSMEG_4641|M.smegmatis_MC2_155 ---------------------------------
MAB_1601c|M.abscessus_ATCC_199 ---------------------------------
MMAR_4944|M.marinum_M ---------------------------------
MUL_0460|M.ulcerans_Agy99 ---------------------------------
MAV_4429|M.avium_104 ---------------------------------
TH_4641|M.thermoresistible__bu FLVRPDGHLAWRGRDATDLADWLKSALTVGRVR
MLBr_02276|M.leprae_Br4923 ---------------------------------