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STDKTSIVVAGAGIGGLASALTLHAAGFEVVVLESAREVKPLGVGINMLPHAVGVLTELGLGERLTRMGI ATTEIRFCDKHGTVLFTEPRGLAGDYPHPQISVHRGRLQLMLLDAVRKRIGPQAVRTASRVLGFESDEAG VRVRTATGDIEAAVLVGADGVNSAIRAQLHPADRLHWSGVRMWRGASDVGPFLTGKTMVVAHDDTDHELI AYPISDRTVNWVALARTNPAGELPAGARWNDPATADEVLDHFPGWDFGWLDLDKMIRGAEYVVEYPMVDR DPLPHWGRDRVTLLGDAAHPMYPLGANGGSQSVVDARALAVALAGHPGDPAGGLSAYESQRIAATHEVVL ANRAMLRSWGDQSPEGLRKTAQSYRRRTRA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2237c | - | - | 100% (381) | hypothetical protein MAB_2237c |
| M. abscessus ATCC 19977 | MAB_0288 | - | 5e-41 | 34.16% (363) | putative monooxygenase (salicylate/ hydroxybenzoate hydroxylase |
| M. abscessus ATCC 19977 | MAB_3330 | - | 7e-33 | 31.82% (352) | putative salicylate hydroxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0590c | - | 1e-12 | 25.86% (348) | hypothetical protein Mb0590c |
| M. gilvum PYR-GCK | Mflv_2621 | - | 2e-26 | 30.82% (318) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv0575c | - | 2e-12 | 25.86% (348) | hypothetical protein Rv0575c |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_4944 | - | 2e-26 | 29.78% (356) | oxidoreductase |
| M. avium 104 | MAV_4429 | - | 1e-16 | 28.00% (350) | FAD binding domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_3841 | - | 1e-102 | 52.45% (387) | hypothetical protein MSMEG_3841 |
| M. thermoresistible (build 8) | TH_0968 | - | 7e-05 | 25.57% (176) | 3-(3-hydroxy-phenyl)propionate hydroxylase |
| M. ulcerans Agy99 | MUL_1770 | - | 4e-13 | 26.29% (350) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_5278 | - | 1e-28 | 29.25% (359) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0590c|M.bovis_AF2122/97 -------MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYMID
Rv0575c|M.tuberculosis_H37Rv -------MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYMID
MUL_1770|M.ulcerans_Agy99 ----MAKPIVLISGAGIAGPALAFWLTHSGYQVVVTELADDIRPGGQTVD
MAB_2237c|M.abscessus_ATCC_199 --MSTDKTSIVVAGAGIGGLASALTLHAAGFEVVVLESAREVKPLGVGIN
MSMEG_3841|M.smegmatis_MC2_155 --MSIT-TTVAIAGAGIGGLTAALALQQRGFEVVVLESAHELRPLGVGIN
MMAR_4944|M.marinum_M -------MKAVIIGAGIGGMSAAIALRQIGIDTEVYERVTENKPVGAAIS
Mvan_5278|M.vanbaalenii_PYR-1 -------MKVVIVGAGMGGMSAAIALRQIGIDTVVYERVTENKPVGAAIS
Mflv_2621|M.gilvum_PYR-GCK -----MSARISVIGAGISGLAAAVALERAGHHVSVIEQRTDTG-AGSGIS
MAV_4429|M.avium_104 MVGDARPLRVLVVGAGVAGISVARGLLRDGHDVTVFERRPRLAAAGGAVT
TH_0968|M.thermoresistible__bu ---MTERVDVVIVGAGPSGLTLANILGLQGVRTLVVEERDTLIDYPRGVG
: *** .* : * * * * * :
Mb0590c|M.bovis_AF2122/97 FWGVGYQVAKRMGITDQIAAAGYHMEHVRSVGPTG-KVKADLGVDVFRRM
Rv0575c|M.tuberculosis_H37Rv FWGVGYQVAKRMGITDQIAAAGYHMEHVRSVGPTG-KVKADLGVDVFRRM
MUL_1770|M.ulcerans_Agy99 LRGAGRLVIERMGLLEQMRQRSLRQRGIAWIRADG-RRRAEMPVEAFHGN
MAB_2237c|M.abscessus_ATCC_199 MLPHAVGVLTELGLGERLTRMGIATTEIRFCDKHG--TVLFTEPRGLAGD
MSMEG_3841|M.smegmatis_MC2_155 LLPHAVRELDHLGLGDAVGDASVAPTAIRFYSADG--TLLFTEPRGLAAG
MMAR_4944|M.marinum_M VWSNGVKCLNYLGLEQQTARLGGIVETMSYAEAHSGETMCRISMQPLIEQ
Mvan_5278|M.vanbaalenii_PYR-1 VWSNGVKCLNYLGLQEETAELGGKVETMSYVDGHTGDTMCRFSMHPLIEQ
Mflv_2621|M.gilvum_PYR-GCK LWPNALAALDQIGLGDSVRDAGGRVTAGAIRWRDG-TWVRRPSVRRIVDA
MAV_4429|M.avium_104 VWSNGETVLRQLGVEMDG--AGRQLSSVGAVTSTG-RPLATLDVTAMARR
TH_0968|M.thermoresistible__bu LDDEALRTFQSIGLVDRILPHTVPNQILRFFDAKR---RLLAEMAPPDAR
. . :*:
Mb0590c|M.bovis_AF2122/97 VGDDFTSLPRGDLAAAIYTTI---EDQVETIFDDSIA----TIDEHRDGV
Rv0575c|M.tuberculosis_H37Rv VGDDFTSLPRGDLAAAIYTTI---EDQVETIFDDSIA----TIDEHRDGV
MUL_1770|M.ulcerans_Agy99 GPVSELEILRGDLAAVLYRAT---AAGTDYRFGTRIT----DLAPSGDAV
MAB_2237c|M.abscessus_ATCC_199 YPHPQISVHRGRLQLMLLDAVRKRIGPQAVRTASRVL----GFESDEAGV
MSMEG_3841|M.smegmatis_MC2_155 DTHPQLSIHRGRLQMLLLAAVRERLGADAVRTGARVS----GFHDDGSRV
MMAR_4944|M.marinum_M VGQRPYPIARAELQQMLMEAY----GIDEIHFGMKMV----EVANRDG--
Mvan_5278|M.vanbaalenii_PYR-1 VGQRPYPIARAELQLMLMKAY----GIDDINFGMKMV----GVENDTAGS
Mflv_2621|M.gilvum_PYR-GCK LGEPLVVVRRSRLTDILREALP----AGTVRTGLAAT----RVSVGASSV
MAV_4429|M.avium_104 LGAPVRMVPRRVLLERLLDGFP----TGRIHCDRRAV----ALATSRDGV
TH_0968|M.thermoresistible__bu FGWPKRNGFVQPMVDAELYAGLDRFDHVEVRFGHRMQNCVEASDAGEDGV
:
Mb0590c|M.bovis_AF2122/97 RLTFERTAP--RDFDLVIGADGLHSNVRRLVFGPERDFEHYLG------C
Rv0575c|M.tuberculosis_H37Rv RLTFERTAP--RDFDLVIGADGLHSNVRRLVFGPERDFEHYLG------C
MUL_1770|M.ulcerans_Agy99 QARLSDGTT--VRADLVVGADGPHSGVRRLAFGPEEQFARPLGGYNAWFS
MAB_2237c|M.abscessus_ATCC_199 RVRTATGD---IEAAVLVGADGVNS-AIRAQLHP-ADRLHWSG-----VR
MSMEG_3841|M.smegmatis_MC2_155 VVRTDAGD---VRADVLVGADGIGS-VVRAALHPGPDPLRFSG-----IT
MMAR_4944|M.marinum_M AATATFADGTIASADILIGADGANS-ITREYVLGGPVTRRYAG-----YV
Mvan_5278|M.vanbaalenii_PYR-1 AAKATFADGTTVSADVIIGADGAGS-ITREYVLGGPVSRRYAG-----YV
Mflv_2621|M.gilvum_PYR-GCK RITLSDGEVR--ESDAVVGADGVNS--VLARTLNGPLRTRYVG-------
MAV_4429|M.avium_104 SVEFTDGTV--AEGDVLIGADGLHSMVREWVGARHAKATGWCS-------
TH_0968|M.thermoresistible__bu TVEFADGHPP-VRASYVVGCDGGRSTTRRLMGVSFDGTTSSTR-------
::*.** *
Mb0590c|M.bovis_AF2122/97 KVAACVVDGYRPRDERSYVLYNTVDR---QLARFALRGDRTMFLFVFRAE
Rv0575c|M.tuberculosis_H37Rv KVAACVVDGYRPRDERSYVLYNTVDR---QLARFALRGDRTMFLFVFRAE
MUL_1770|M.ulcerans_Agy99 APDTVGLNGWYLMYQAPGGLNASMRP---SHDPATAKAGLAFRSAPIRYD
MAB_2237c|M.abscessus_ATCC_199 MWRGASDVGPFLTGKTMVVAHDDTDH---ELIAYPISDRTVNWVALARTN
MSMEG_3841|M.smegmatis_MC2_155 MFRGAGRMAAFLDGHTMAIVKGDRGDQGVDLVTYPIAPDLVNWVVQVPQS
MMAR_4944|M.marinum_M NYNGLVEVDEAISPANEWTMYVGDGK---RVSAMPVADDRFYFFFDVVEP
Mvan_5278|M.vanbaalenii_PYR-1 NYNGLVSTDDAIGPATEWTTYVGDGK---RVSVMPVSDDRFYFFFDVVEP
Mflv_2621|M.gilvum_PYR-GCK -YTAWRGIAAHPLDPELGGETLGPGT---QVGHVPLGPDHTYWFATERTA
MAV_4429|M.avium_104 -WQGLVSLPEIAESDAALMMIGGSGN----LGLWPAGGAEVQWWFDLPWS
TH_0968|M.thermoresistible__bu --WLVVDVANDPLGHPNSEVGADPAR---PYVSISIAHGIRRFEFMIHPH
.
Mb0590c|M.bovis_AF2122/97 --------HDNPGVAPKDELRDQFGDVGWESRDILAALD-DVEDLYFDVV
Rv0575c|M.tuberculosis_H37Rv --------HDNPGVAPKDELRDQFGDVGWESRDILAALD-DVEDLYFDVV
MUL_1770|M.ulcerans_Agy99 --------RGD-LDAQRDLLAACFAGAGWQSDALIAAAR-EADDFYLDAI
MAB_2237c|M.abscessus_ATCC_199 PAGELPAGARWNDPATADEVLDHFPGWDFGWLDLDKMIRGAEYVVEYPMV
MSMEG_3841|M.smegmatis_MC2_155 ----APTSAGWNTPASAADVLPHVAGWRLDWLDVDSLIGSTPQIFTYPMV
MMAR_4944|M.marinum_M ------EGLPFEKGTAREVLREQFAGWAPGVQALIDKLD-PTTTNRVEIL
Mvan_5278|M.vanbaalenii_PYR-1 ------QGSPYEEGRVREVLRAHFAGWTPGVQTLIDTLD-PLATNRVEIL
Mflv_2621|M.gilvum_PYR-GCK E-------GGSAPGGEHAYLTAKVADWADPIPRLVATTD-PGDLLRNDLY
MAV_4429|M.avium_104 -------TGFVRPQHPIETIRSHFAGWSEPVDRVLAILTDEDLAASPFPH
TH_0968|M.thermoresistible__bu ---------ETDAEVDDPAFVRRMLGRRIPYPERVDMIR-----YRVYTH
. . .
Mb0590c|M.bovis_AF2122/97 SQIRMDRWSRG-RVLLIGDAAGCISLLGGEGTGLAITEAYVLAGELARAG
Rv0575c|M.tuberculosis_H37Rv SQIRMDRWSRG-RVLLIGDAAGCISLLGGEGTGLAITEAYVLAGELARAG
MUL_1770|M.ulcerans_Agy99 VQIHLDAWSRG-RVTLVGDAGYCASPLSGMGTSLALVGAYVLAGELGPAH
MAB_2237c|M.abscessus_ATCC_199 DRDPLPHWGRD-RVTLLGDAAHPMYPLGANGGSQSVVDARALAVALAGHP
MSMEG_3841|M.smegmatis_MC2_155 DKDPVRQWGRGGRVTLLGDAAHPMYPVGANGGSQAVVDARVLADHLAEAG
MMAR_4944|M.marinum_M DLDPFHTWVKG-RVAVLGDAAHNTTPDIGQGGCSAMEDAVALQWALKDNP
Mvan_5278|M.vanbaalenii_PYR-1 DLDPFHTWVKG-RVAVLGDAAHNTTPDIGQGGCSAMEDAIALQWAFKDHP
Mflv_2621|M.gilvum_PYR-GCK DRARAARWSDG-RAVLIGDAAHPMRPHLGQGGCQGIEDAAILARFLELAD
MAV_4429|M.avium_104 FRHPIPPPGRG-RVTLLGDAAHTMPPTLAQGTNQALLDTMVLCQALADFG
TH_0968|M.thermoresistible__bu HSRIAGSFRKG-RLLLAGDAAHLMPVWQGQGYNSGIRDAANLGWKLAAVV
. * : ***. . * .: : * :
Mb0590c|M.bovis_AF2122/97 GD-------HRRAFDAYEKRLRPFIEGK---QASAAKFIWFFRHPN----
Rv0575c|M.tuberculosis_H37Rv GD-------HRRAFDAYEKRLRPFIEGK---QASAAKFIWFFATRTR--F
MUL_1770|M.ulcerans_Agy99 GDGID-EAALAAALARYETVLRPYVANC---QDLPNSIDRFLPMSESEIR
MAB_2237c|M.abscessus_ATCC_199 GD-------PAGGLSAYESQRIAATHEV---VLANRAMLRSWGDQSP---
MSMEG_3841|M.smegmatis_MC2_155 ----------VRGLRTYEAERADETAAV---IVANREMHRAANTRSA---
MMAR_4944|M.marinum_M TD-------VAAALAAYQASRTERAGDL---VLRARKRCDVIHAKDP---
Mvan_5278|M.vanbaalenii_PYR-1 DD-------VHAALAAYQSARTERAADL---VLRARKRCDVTHAKDP---
Mflv_2621|M.gilvum_PYR-GCK DVP--------TAFERFEAFRKPRVGML---VREAQTLGRIVNVRPAVLS
MAV_4429|M.avium_104 RGTPGGQADVANALRWYEKTRRRRVRAVS-WVASLPVSHGEAVLRPAALV
TH_0968|M.thermoresistible__bu NG-----HAHDALLDTYDLERREHARAMIDLSTMVGRVISPTNRRVAALR
: ::
Mb0590c|M.bovis_AF2122/97 --PIRPVVSQRCDAHDELRPAGDAVRRQRA--------------------
Rv0575c|M.tuberculosis_H37Rv GLWFRNVAMRTMNFGPLATLFAGSVRDDFELPDYTW--------------
MUL_1770|M.ulcerans_Agy99 SNAAAMKYMQRWPFRFFAERKWFTIAESIELPRYPRLP------------
MAB_2237c|M.abscessus_ATCC_199 --EGLRKTAQSYR----RRTRA----------------------------
MSMEG_3841|M.smegmatis_MC2_155 --TELDRVTRKYRTDTARSTRA----------------------------
MMAR_4944|M.marinum_M --DTTAAWYEELRNEDGTNIIRGLVANIMGGPLTPLS-------------
Mvan_5278|M.vanbaalenii_PYR-1 --QVTSRWYDELRNEDGTNIIRGIVGNIVGGPLTPVTAATEG--------
Mflv_2621|M.gilvum_PYR-GCK GLAGRATALIPERMVTAHLAWIAAGSAFVLPTAADLAR------------
MAV_4429|M.avium_104 SDRLQAAALTMFLRWTSHRRMSDHINRSVGEAINRSLGEAPKIPSRR---
TH_0968|M.thermoresistible__bu DRLIHAASVVPTLKRYVLEMRFKPMPRYLQGAVYHGGPRSKSSPTGTLFI
Mb0590c|M.bovis_AF2122/97 --------------------------------------------------
Rv0575c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1770|M.ulcerans_Agy99 --------------------------------------------------
MAB_2237c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3841|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4944|M.marinum_M --------------------------------------------------
Mvan_5278|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
MAV_4429|M.avium_104 --------------------------------------------------
TH_0968|M.thermoresistible__bu QPRVDTRDAENVLLDDVLGPGFAVLCWSNNLRAVLGEDAFSHWKSLGATF
Mb0590c|M.bovis_AF2122/97 --------------------------------------------------
Rv0575c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1770|M.ulcerans_Agy99 --------------------------------------------------
MAB_2237c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3841|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4944|M.marinum_M --------------------------------------------------
Mvan_5278|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
MAV_4429|M.avium_104 --------------------------------------------------
TH_0968|M.thermoresistible__bu VEARPITQLHWPGHDDPDVVVVGDRTGALKGWFDVHTDSVLFLRPDRCIA
Mb0590c|M.bovis_AF2122/97 --------------------------------------------------
Rv0575c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1770|M.ulcerans_Agy99 --------------------------------------------------
MAB_2237c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3841|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4944|M.marinum_M --------------------------------------------------
Mvan_5278|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
MAV_4429|M.avium_104 --------------------------------------------------
TH_0968|M.thermoresistible__bu AACIAQRAPETSAALSEVMCLTQGGGNGAASPVLHVAQSAAEPSGTATRS
Mb0590c|M.bovis_AF2122/97 -
Rv0575c|M.tuberculosis_H37Rv -
MUL_1770|M.ulcerans_Agy99 -
MAB_2237c|M.abscessus_ATCC_199 -
MSMEG_3841|M.smegmatis_MC2_155 -
MMAR_4944|M.marinum_M -
Mvan_5278|M.vanbaalenii_PYR-1 -
Mflv_2621|M.gilvum_PYR-GCK -
MAV_4429|M.avium_104 -
TH_0968|M.thermoresistible__bu T