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VKAVIIGAGIGGMSAAIALRQIGIDTEVYERVTENKPVGAAISVWSNGVKCLNYLGLEQQTARLGGIVET MSYAEAHSGETMCRISMQPLIEQVGQRPYPIARAELQQMLMEAYGIDEIHFGMKMVEVANRDGAATATFA DGTIASADILIGADGANSITREYVLGGPVTRRYAGYVNYNGLVEVDEAISPANEWTMYVGDGKRVSAMPV ADDRFYFFFDVVEPEGLPFEKGTAREVLREQFAGWAPGVQALIDKLDPTTTNRVEILDLDPFHTWVKGRV AVLGDAAHNTTPDIGQGGCSAMEDAVALQWALKDNPTDVAAALAAYQASRTERAGDLVLRARKRCDVIHA KDPDTTAAWYEELRNEDGTNIIRGLVANIMGGPLTPLS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4944 | - | - | 100% (388) | oxidoreductase |
| M. marinum M | MMAR_4675 | - | 2e-20 | 25.75% (334) | membrane-associated oxidoreductase |
| M. marinum M | MMAR_0939 | - | 1e-16 | 26.57% (335) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0590c | - | 2e-13 | 24.55% (334) | hypothetical protein Mb0590c |
| M. gilvum PYR-GCK | Mflv_2621 | - | 3e-38 | 29.80% (349) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv0575c | - | 2e-13 | 24.55% (334) | hypothetical protein Rv0575c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3330 | - | 4e-38 | 31.78% (365) | putative salicylate hydroxylase |
| M. avium 104 | MAV_4429 | - | 8e-35 | 29.41% (357) | FAD binding domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4641 | - | 4e-38 | 29.69% (357) | salicylate hydroxylase |
| M. thermoresistible (build 8) | TH_4641 | - | 2e-09 | 24.57% (346) | PUTATIVE oxygenase |
| M. ulcerans Agy99 | MUL_0460 | - | 1e-115 | 96.26% (214) | hypothetical protein MUL_0460 |
| M. vanbaalenii PYR-1 | Mvan_5278 | - | 0.0 | 81.03% (390) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2621|M.gilvum_PYR-GCK -----MSARISVIGAGISGLAAAVALERAGHHVSVIEQRTDT-GAGSGIS
MSMEG_4641|M.smegmatis_MC2_155 -----MAASFLVVGAGITGLATAAALQRRGHDVCVAEARADT-ASGAGIS
MAB_3330|M.abscessus_ATCC_1997 -------MRVAIIGAGIGGLTAAAALRANDIDVIVYEKAHELREVGAGVV
MMAR_4944|M.marinum_M -------MKAVIIGAGIGGMSAAIALRQIGIDTEVYERVTENKPVGAAIS
Mvan_5278|M.vanbaalenii_PYR-1 -------MKVVIVGAGMGGMSAAIALRQIGIDTVVYERVTENKPVGAAIS
MUL_0460|M.ulcerans_Agy99 -------MKAVIIGAGIGGMSAAIALRQIGIDTEVYERVTENKPVGAAIS
Mb0590c|M.bovis_AF2122/97 -------MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYMID
Rv0575c|M.tuberculosis_H37Rv -------MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYMID
MAV_4429|M.avium_104 MVGDARPLRVLVVGAGVAGISVARGLLRDGHDVTVFERRPRLAAAGGAVT
TH_4641|M.thermoresistible__bu -MARETTTDVVVVGAGPVGLAVACGLLAHGLDVRVIDKAPAPATTSRANF
: *** * : * * . * : .
Mflv_2621|M.gilvum_PYR-GCK LWPNALAALDQIGLGDSVRDAGGRVTAGAIR-WRDGTWVRRPSVRRIVDA
MSMEG_4641|M.smegmatis_MC2_155 IWPNALAALDAIGLGDPVRAAGGRVTAGALR-WHDGTWLRHPAAERITRA
MAB_3330|M.abscessus_ATCC_1997 IANNGLRALDEVGLGDRVRAVGTQIRRTLWHTWQGESVPVPPAWPAVSPD
MMAR_4944|M.marinum_M VWSNGVKCLNYLGLEQQTARLGGIVETMSYAEAHSGETMCRISMQPLIEQ
Mvan_5278|M.vanbaalenii_PYR-1 VWSNGVKCLNYLGLQEETAELGGKVETMSYVDGHTGDTMCRFSMHPLIEQ
MUL_0460|M.ulcerans_Agy99 VWSNGVKCLNYLGLDQQTARLGGIVETMSYAEAHSGETMCRISMQPLIEQ
Mb0590c|M.bovis_AF2122/97 FWGVGYQVAKRMGITDQIAAAGYHMEHVRSVG-PTGKVKADLGVDVFRRM
Rv0575c|M.tuberculosis_H37Rv FWGVGYQVAKRMGITDQIAAAGYHMEHVRSVG-PTGKVKADLGVDVFRRM
MAV_4429|M.avium_104 VWSNGETVLRQLGVEMDG---AGRQLSSVGAVTSTGRPLATLDVTAMARR
TH_4641|M.thermoresistible__bu LHARGSEVLDRLGALGGLPE--RSVRAMQITTHLGGEPVMRMQFGDPGMR
. . :*
Mflv_2621|M.gilvum_PYR-GCK LGEPLVVVRRSRLTDILREALP--AGTVRTGLAATRVSVGAS--SVRITL
MSMEG_4641|M.smegmatis_MC2_155 LGEPLVVIRRRVLTEILSGALA--PGTVVHGLEAHTVETCAS--GIRVTF
MAB_3330|M.abscessus_ATCC_1997 RPVTSLPVHRGELQHALLGALP--AGTVQLGRPCQDIVETAD--EVRIIF
MMAR_4944|M.marinum_M VGQRPYPIARAELQQMLMEAYG--IDEIHFGMKMVEVANRDG--AATATF
Mvan_5278|M.vanbaalenii_PYR-1 VGQRPYPIARAELQLMLMKAYG--IDDINFGMKMVGVENDTAGSAAKATF
MUL_0460|M.ulcerans_Agy99 VGQRPYPIARAELQQMLMEAYG--IDDIHFGMKMVEVANQDG--AATATF
Mb0590c|M.bovis_AF2122/97 VGDDFTSLPRGDLAAAIYTTIED-QVETIFDDSIATIDEHRD--GVRLTF
Rv0575c|M.tuberculosis_H37Rv VGDDFTSLPRGDLAAAIYTTIED-QVETIFDDSIATIDEHRD--GVRLTF
MAV_4429|M.avium_104 LGAPVRMVPRRVLLERLLDGFP--TGRIHCDRRAVALATSRD--GVSVEF
TH_4641|M.thermoresistible__bu TAAPPMVISQAEVEAALRNRLAELGGRVELDCPLTGLRQDAS--TVTAGI
: : : : . : :
Mflv_2621|M.gilvum_PYR-GCK SDGEVRESDAVVGADGVNSVLARTLNG-PLRTRYVGYTAWRGIAAHP---
MSMEG_4641|M.smegmatis_MC2_155 SDGSVREASAVVGADGVDSVVARHLNG-PLRRRYAGYTAWRGIAAHP---
MAB_3330|M.abscessus_ATCC_1997 ADGSEERADVAVGADGIHSAVQRVVAD-PVELSSDGIMAYRGLIPVERLD
MMAR_4944|M.marinum_M ADGTIASADILIGADGANSITREYVLGGPVTRRYAGYVNYNGLVEVDEAI
Mvan_5278|M.vanbaalenii_PYR-1 ADGTTVSADVIIGADGAGSITREYVLGGPVSRRYAGYVNYNGLVSTDDAI
MUL_0460|M.ulcerans_Agy99 TDGTIASADILIGADGANSITREYVLGGPVTRRYAGYVNYNGLVEVDEAI
Mb0590c|M.bovis_AF2122/97 ERTAPRDFDLVIGADGLHSNVRRLVFG--PERDFEHYLGCKVAACVVDGY
Rv0575c|M.tuberculosis_H37Rv ERTAPRDFDLVIGADGLHSNVRRLVFG--PERDFEHYLGCKVAACVVDGY
MAV_4429|M.avium_104 TDGTVAEGDVLIGADGLHSMVREWVGA--RHAKATGWCSWQGLVSLP---
TH_4641|M.thermoresistible__bu GGGGELRGRWLVGCDGTGSSTRKSVGIGYPGAR----LSERFLLADVYLD
:*.** * . : .
Mflv_2621|M.gilvum_PYR-GCK --LDPELGGETLGPGTQVGHVPLG----PDHTYWFATERTAEGGSAPGGE
MSMEG_4641|M.smegmatis_MC2_155 --LDPELSGETMGAGVEVGHVPLG----ADHTYWFATERASQGQRSPDGE
MAB_3330|M.abscessus_ATCC_1997 GVIDLNSMQMWLGPGRSFLIYPVSRGRLLNVVAFTPSNLDAEESWTAPGD
MMAR_4944|M.marinum_M SPAN--EWTMYVGDGKRVSAMPVA--DDR-FYFFFDVVEPEGLPFEKGTA
Mvan_5278|M.vanbaalenii_PYR-1 GPAT--EWTTYVGDGKRVSVMPVS--DDR-FYFFFDVVEPQGSPYEEGRV
MUL_0460|M.ulcerans_Agy99 SPAN--EWTMYVGDGKRVSAMPPT--TPRPASGRADARRWKTRWHCNGRS
Mb0590c|M.bovis_AF2122/97 RPRDERSYVLYNTVDRQLARFALR--GDRTMFLFVFRAEHDNPGVAP---
Rv0575c|M.tuberculosis_H37Rv RPRDERSYVLYNTVDRQLARFALR--GDRTMFLFVFRAEHDNPGVAP---
MAV_4429|M.avium_104 EIAESDAALMMIGGSGNLGLWPAG----GAEVQWWFDLPWSTGFVRPQHP
TH_4641|M.thermoresistible__bu WRLDRSGTTGWIHPDGMVGAMPMP------DGLWRIIAYDPGPGDLDQGA
. . .
Mflv_2621|M.gilvum_PYR-GCK HAYLTAKVADWADPIPRLVATTDPGDLLRNDLYDR-ARAARWSDGRAVLI
MSMEG_4641|M.smegmatis_MC2_155 LTHLRRLFGSWAEPIPQLLAATDPADVLRNDLYDR-EPARCWARGPVVLA
MAB_3330|M.abscessus_ATCC_1997 VAELSAEFAGWDQPVQRVAGAMT--ETFRWGLYDR-KPLNRWTTDRIALL
MMAR_4944|M.marinum_M REVLREQFAGWAPGVQALIDKLDPTTTNRVEILDL-DPFHTWVKGRVAVL
Mvan_5278|M.vanbaalenii_PYR-1 REVLRAHFAGWTPGVQTLIDTLDPLATNRVEILDL-DPFHTWVKGRVAVL
MUL_0460|M.ulcerans_Agy99 RTTPPTLRPRWPP--------IRPAAPNGPAIWYC-GPVS----------
Mb0590c|M.bovis_AF2122/97 KDELRDQFGDVGWESRDILAALDDVEDLYFDVVSQ-IRMDRWSRGRVLLI
Rv0575c|M.tuberculosis_H37Rv KDELRDQFGDVGWESRDILAALDDVEDLYFDVVSQ-IRMDRWSRGRVLLI
MAV_4429|M.avium_104 IETIRSHFAGWSEPVDRVLAILTDEDLAASPFPHFRHPIPPPGRGRVTLL
TH_4641|M.thermoresistible__bu LERLLYERTGHRVKVTG--------TVWQSEFRVHRRLADTYRRGRVFIA
.
Mflv_2621|M.gilvum_PYR-GCK GDAAHPMRPHLGQGGCQGIEDAAILARFLELA--------DDVPTAFERF
MSMEG_4641|M.smegmatis_MC2_155 GDAAHPMRPHLGQGGCQGLEDAATLAALVARE--------PDLPTAFARF
MAB_3330|M.abscessus_ATCC_1997 GDAAHPMTPHLGQGANMSIEDAVVLATVLAGAS------ATEVPRRLSLY
MMAR_4944|M.marinum_M GDAAHNTTPDIGQGGCSAMEDAVALQWALKDN-------PTDVAAALAAY
Mvan_5278|M.vanbaalenii_PYR-1 GDAAHNTTPDIGQGGCSAMEDAIALQWAFKDH-------PDDVHAALAAY
MUL_0460|M.ulcerans_Agy99 --AATSSTP-----------------------------------------
Mb0590c|M.bovis_AF2122/97 GDAAGCISLLGGEGTGLAITEAYVLAGELARA-------GGDHRRAFDAY
Rv0575c|M.tuberculosis_H37Rv GDAAGCISLLGGEGTGLAITEAYVLAGELARA-------GGDHRRAFDAY
MAV_4429|M.avium_104 GDAAHTMPPTLAQGTNQALLDTMVLCQALADFGRGTPGGQADVANALRWY
TH_4641|M.thermoresistible__bu GDAAHAHAPFGGQGMLTGLGDAENLAFKLALVIR-----GYAGPALLDTY
**
Mflv_2621|M.gilvum_PYR-GCK EAFRKPRVGML--------VREAQTLGRIVNVRPAVLSGLAGRATALIPE
MSMEG_4641|M.smegmatis_MC2_155 ATLRRRRVTRM--------VRTSRMIGRIVNLRPAVLSAAASRATVLVPE
MAB_3330|M.abscessus_ATCC_1997 ESLRRDRTSRV--------QRNARQSGRVYRSVDLTAQQQAAQLTEILAD
MMAR_4944|M.marinum_M QASRTERAGDL--------VLRARKRCDVIHAKDPDTTAAWYEELRNEDG
Mvan_5278|M.vanbaalenii_PYR-1 QSARTERAADL--------VLRARKRCDVTHAKDPQVTSRWYDELRNEDG
MUL_0460|M.ulcerans_Agy99 ---RTPIPPQP--------GMRS---CETNTAP-----------------
Mb0590c|M.bovis_AF2122/97 EKRLRPFIEGK--------QASAAKFIWFFRHPN----PIRPVVSQRCDA
Rv0575c|M.tuberculosis_H37Rv EKRLRPFIEGK--------QASAAKFIWFFATRTRFGLWFRNVAMRTMNF
MAV_4429|M.avium_104 EKTRRRRVRAVSW-VASLPVSHGEAVLRPAALVSDRLQAAALTMFLRWTS
TH_4641|M.thermoresistible__bu EAERRPLATEVLRNTSAATKLNIADRGVGRFLRDRVVLPLLALPSVQRRL
Mflv_2621|M.gilvum_PYR-GCK RMVTAHLAWIAAGSAFVLPTAADLAR------------------------
MSMEG_4641|M.smegmatis_MC2_155 AVLTRQLASIAARSAFTPVD------------------------------
MAB_3330|M.abscessus_ATCC_1997 NWIPDYDAAATAGTALATL-------------------------------
MMAR_4944|M.marinum_M TNIIRGLVANIMGGPLTPLS------------------------------
Mvan_5278|M.vanbaalenii_PYR-1 TNIIRGIVGNIVGGPLTPVTAATEG-------------------------
MUL_0460|M.ulcerans_Agy99 TSFAGSSPTSWVGRSLR---------------------------------
Mb0590c|M.bovis_AF2122/97 HDELRPAGDAVRRQRA----------------------------------
Rv0575c|M.tuberculosis_H37Rv GPLATLFAGSVRDDFELPDYTW----------------------------
MAV_4429|M.avium_104 HRRMSDHINRSVGEAINRSLGEAPKIPSRR--------------------
TH_4641|M.thermoresistible__bu TYQTSQLWVTYRGGPLAPRTVSMTTPRPGDRVPDQRCVRDDGHISRLYEQ
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4641|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3330|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_4944|M.marinum_M --------------------------------------------------
Mvan_5278|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_0460|M.ulcerans_Agy99 --------------------------------------------------
Mb0590c|M.bovis_AF2122/97 --------------------------------------------------
Rv0575c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4429|M.avium_104 --------------------------------------------------
TH_4641|M.thermoresistible__bu LGGRWAVLEPGSGRHHREGPGLLGTAHTFLGEYVVGLRGAEMRGCDAFLV
Mflv_2621|M.gilvum_PYR-GCK ------------------------------
MSMEG_4641|M.smegmatis_MC2_155 ------------------------------
MAB_3330|M.abscessus_ATCC_1997 ------------------------------
MMAR_4944|M.marinum_M ------------------------------
Mvan_5278|M.vanbaalenii_PYR-1 ------------------------------
MUL_0460|M.ulcerans_Agy99 ------------------------------
Mb0590c|M.bovis_AF2122/97 ------------------------------
Rv0575c|M.tuberculosis_H37Rv ------------------------------
MAV_4429|M.avium_104 ------------------------------
TH_4641|M.thermoresistible__bu RPDGHLAWRGRDATDLADWLKSALTVGRVR