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VDQPWNANIHYDALLDAMVPLGTQCVLDVGCGDGLLAARLARRIPYVTAVDIDAPVLRRAQTRFANAPIR WLHADIMTAELPNAGFDAVVSNAALHHIEDTRTALSRLGGLVTPGGTLAVVTFVTPSLRNGLWHLTSWVA CGMANRVKGKWEHSAPIKWPPPQTLHELRSHVRALLPGACIRRLLYGRVLVTWRAPV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0089 | - | - | 100% (197) | POSSIBLE METHYLTRANSFERASE/METHYLASE |
| M. tuberculosis H37Rv | Rv0839 | - | 3e-08 | 35.35% (99) | hypothetical protein Rv0839 |
| M. tuberculosis H37Rv | Rv0294 | tam | 3e-06 | 35.14% (111) | trans-aconitate methyltransferase tam |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0092 | - | 1e-116 | 100.00% (197) | methyltransferase/methylase |
| M. gilvum PYR-GCK | Mflv_4692 | - | 7e-11 | 35.78% (109) | methyltransferase type 11 |
| M. leprae Br4923 | MLBr_00130 | - | 2e-06 | 25.74% (136) | hypothetical protein MLBr_00130 |
| M. abscessus ATCC 19977 | MAB_1294c | - | 7e-24 | 33.51% (191) | hypothetical protein MAB_1294c |
| M. marinum M | MMAR_0244 | - | 1e-80 | 71.65% (194) | methyltransferase/methylase |
| M. avium 104 | MAV_0854 | - | 8e-09 | 38.00% (100) | methyltransferase-UbiE family protein |
| M. smegmatis MC2 155 | MSMEG_4708 | - | 2e-21 | 36.98% (192) | putative methyltransferase |
| M. thermoresistible (build 8) | TH_3395 | - | 2e-09 | 39.05% (105) | PUTATIVE putative ubiquinone/menaquinone biosynthesis |
| M. ulcerans Agy99 | MUL_4869 | - | 2e-76 | 68.56% (194) | methyltransferase/methylase |
| M. vanbaalenii PYR-1 | Mvan_4082 | - | 7e-20 | 33.50% (200) | methyltransferase type 12 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0089|M.tuberculosis_H37Rv -----------------------------MDQPWN------ANIHYDALL
Mb0092|M.bovis_AF2122/97 -----------------------------MDQPWN------ANIHYDALL
MMAR_0244|M.marinum_M ---------------------------MPAGQPWN------INIHYDALL
MUL_4869|M.ulcerans_Agy99 ---------------------------MPAGQPWN------INIHYDALL
MSMEG_4708|M.smegmatis_MC2_155 ---------------------------MPSPAYWN------HNTAYHPWL
Mvan_4082|M.vanbaalenii_PYR-1 -----------------------------MQDYWN------HNTAYHPWL
MAB_1294c|M.abscessus_ATCC_199 ---------------------------MPDHGRWN------HNIHYQREV
MAV_0854|M.avium_104 ---------------------------MNDQHRAT------YTHGHHESV
TH_3395|M.thermoresistible__bu --------------------------MADVAANWAGRGGRFAGGLYDFGV
Mflv_4692|M.gilvum_PYR-GCK ---------------------------MTSSTFWSAGRYDAVGDRIAPIA
MLBr_00130|M.leprae_Br4923 MAFTRIHSFLASAGNTSMYKRVWRFWYPLMTHKLGTDEIMFINWAYEEDP
Rv0089|M.tuberculosis_H37Rv DAMVPLGTQC--------------------------VLDVGCGDGLLAAR
Mb0092|M.bovis_AF2122/97 DAMVPLGTQC--------------------------VLDVGCGDGLLAAR
MMAR_0244|M.marinum_M AATVAPGTQT--------------------------ALDVGCGDGFLSAR
MUL_4869|M.ulcerans_Agy99 AATVAPGTQT--------------------------ALDVGCGDGFLSAR
MSMEG_4708|M.smegmatis_MC2_155 RRIAAQHRGD--------------------------VLDVGCGDGLLAQR
Mvan_4082|M.vanbaalenii_PYR-1 VGIAGEHRGD--------------------------VLDIGCGDGLLAQR
MAB_1294c|M.abscessus_ATCC_199 LRRVPAHATD--------------------------VLDVGCGIGMLTRE
MAV_0854|M.avium_104 LRSHRRRTAEDSAG-----------YLLAHLTPGLSVLDVGCGPGTITAD
TH_3395|M.thermoresistible__bu EREVLARPAGLLMWGTDTRLLFDSIRRIGDLPDGTAVLDIPCGGGLALRG
Mflv_4692|M.gilvum_PYR-GCK REVVDAADARRPLR-------------------DAAVVDLACGTGSAALD
MLBr_00130|M.leprae_Br4923 PMALPLEASDEPNRAHIN---LYHRTATQVNLSGKRILEVSCGHGGGASY
::: ** *
Rv0089|M.tuberculosis_H37Rv LARRIP--YVTAVDIDAPVLRRAQTRFA---NAPIRWLHADIMTAELPNA
Mb0092|M.bovis_AF2122/97 LARRIP--YVTAVDIDAPVLRRAQTRFA---NAPIRWLHADIMTAELPNA
MMAR_0244|M.marinum_M LADRVP--DVTALDVDADVLRRAERRFA---DTSIRWVHGDVMTGELPHR
MUL_4869|M.ulcerans_Agy99 LVDRVP--DVTALDVDADVLRRAEHRFA---DTSIWWVHGDVMTGELPHR
MSMEG_4708|M.smegmatis_MC2_155 LAPVSR--SVTAIEPDPQTLQRAWVRLAH--LPNVTVAQNDFDTFDPGTH
Mvan_4082|M.vanbaalenii_PYR-1 LLPVSR--SVTLIDPDPDSVARAQARLAG--HADVSISQQSFHDYRPGTA
MAB_1294c|M.abscessus_ATCC_199 LAPLAQ--RVVGIDPHEPSLRIARAETS---ASNVEYVRGSFLEHPFPAE
MAV_0854|M.avium_104 LAARVAPGQVTAVDQAADVLEVARAEAEQRNLSNVSFGTADVHRLDFADD
TH_3395|M.thermoresistible__bu LRHGRR-LRYVAADISADMLARAQRRAATLGRTDVRFVVADIERMPFGDG
Mflv_4692|M.gilvum_PYR-GCK AAARGA--RVTGVDITPELIAIAAERDG---AAAVRWRTGDASDTGLPAT
MLBr_00130|M.leprae_Br4923 LTRALHPASYTGLDLNPAGIKLCQKRHQ---LPGLEFVRGDAENLPFDNE
. : : . . . : .
Rv0089|M.tuberculosis_H37Rv GFDAVVSNAALHHIEDTRTALSRLGGLVTPGGTLAVVTFV--T-PSLRNG
Mb0092|M.bovis_AF2122/97 GFDAVVSNAALHHIEDTRTALSRLGGLVTPGGTLAVVTFV--T-PSLRNG
MMAR_0244|M.marinum_M GFDAVLANASLHHIEDTRGALIRLAELVLPAGTLAVVTFV--R-PSLRNG
MUL_4869|M.ulcerans_Agy99 GFDAVLASASLHHIEGTRGALIRLAELVLPGGTLAVVTFV--R-PSPRNV
MSMEG_4708|M.smegmatis_MC2_155 RFDVVTMVATLHHMD-LRAALSKARELLTPTGEIAVVGLS--ANKTLRDW
Mvan_4082|M.vanbaalenii_PYR-1 LFDVITFVASLHHMA-LRESLRKARALLRPGGELAVVGLS--ANRSASDW
MAB_1294c|M.abscessus_ATCC_199 SFDLIAAVAALHHMD-IEQGLRRMSDLLKPGGRIVIVGFA--ANRSVTDL
MAV_0854|M.avium_104 TFDVVHAHQVLQHLSDPVAALREMRRVCRPGGIVAVRDAD--YAGFIWYP
TH_3395|M.thermoresistible__bu EFDCCVTFNGLHCVPDPAAAVAEIARCVKPGG------------RLIGDA
Mflv_4692|M.gilvum_PYR-GCK SFDAAVSNMGIIFVE-PARQVAEVVRLLKPGGVFAFSSWVRSVSNPLFDP
MLBr_00130|M.leprae_Br4923 SFDVVINIEASHCYPHFPRFLAEVVRVLRPGGHLAYADLRPSNKVGEWEV
** : . * *
Rv0089|M.tuberculosis_H37Rv LWHLTSWVAC------------GMANRVKGKWEHSAP----IKWPPPQTL
Mb0092|M.bovis_AF2122/97 LWHLTSWVAC------------GMANRVKGKWEHSAP----IKWPPPQTL
MMAR_0244|M.marinum_M LWHLTAWLAT------------GVANRVRRKWEHTAA----IKWPPPVTF
MUL_4869|M.ulcerans_Agy99 LWHLTAWLAT------------GVANRVRRKWDHTAA----IKWPPPVTF
MSMEG_4708|M.smegmatis_MC2_155 AWSGLCLPAV------------RLGSFCHRETRDIGV----PVAEPAENL
Mvan_4082|M.vanbaalenii_PYR-1 IWSGLCLPAV------------RIGSRLHRETRDIGV----VVAQPRESL
MAB_1294c|M.abscessus_ATCC_199 WYDGLGFWLH------------RYYRLRYGWWEHPSP----VSCEGLDSH
MAV_0854|M.avium_104 ELPALDLWRD------------LYRRVARANRGEPDAGRRLLSWARQAGF
TH_3395|M.thermoresistible__bu VVRGAGRRQD------------ALIAVFRRAG----------VFGPGGTT
Mflv_4692|M.gilvum_PYR-GCK VLAVLGPPATSTFSPDQWGDEAVLTERLGSQFDGVDVRRGDHRWEFESMP
MLBr_00130|M.leprae_Br4923 DFANSRLQQLS---------QREINAEVLRGIASNSQKSRDLVDRHLPAF
Rv0089|M.tuberculosis_H37Rv HELR----------------------------SHVRALLPGACIRRLLYG
Mb0092|M.bovis_AF2122/97 HELR----------------------------SHVRALLPGACIRRLLYG
MMAR_0244|M.marinum_M SQLR----------------------------ELVRELLPGARVRRLLYG
MUL_4869|M.ulcerans_Agy99 SQLR----------------------------ELVRELLPGARVRRLLYG
MSMEG_4708|M.smegmatis_MC2_155 DEIR----------------------------RVAADVLPGAMIRRALYY
Mvan_4082|M.vanbaalenii_PYR-1 REIR----------------------------LVSDDVIPGAVVRRALYY
MAB_1294c|M.abscessus_ATCC_199 DEVR----------------------------RIAQRVLPGARLQRLVLW
MAV_0854|M.avium_104 DDITPTGSLWCYATPETRDWWGGMWADRILHSTVARDLVSLGLAAREQLE
TH_3395|M.thermoresistible__bu DELQG---------------------------WLTRAGFEVEDFRRSGAV
Mflv_4692|M.gilvum_PYR-GCK AAMRFLTSE---------------------SPMHVETFRRAETSQRARLA
MLBr_00130|M.leprae_Br4923 LRFAG----------------------------REFIGVQGTQLSRYLEG
. *
Rv0089|M.tuberculosis_H37Rv RVLVTWRAPV----------------------
Mb0092|M.bovis_AF2122/97 RVLVTWRAPV----------------------
MMAR_0244|M.marinum_M RVLITWQAPG----------------------
MUL_4869|M.ulcerans_Agy99 RVLITWQAPG----------------------
MSMEG_4708|M.smegmatis_MC2_155 RYLLRWQPAN----------------------
Mvan_4082|M.vanbaalenii_PYR-1 RYLLRWRKPA----------------------
MAB_1294c|M.abscessus_ATCC_199 RHLLTWEKS-----------------------
MAV_0854|M.avium_104 EISAAWREWAAAPDGWIAIPHGEIICRA----
TH_3395|M.thermoresistible__bu AHFTAVRS------------------------
Mflv_4692|M.gilvum_PYR-GCK AEFEDALRPHLEPSGSVAFLSPYVVVTATLRG
MLBr_00130|M.leprae_Br4923 GELSYRMYSFAKD-------------------