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VNDQHRATYTHGHHESVLRSHRRRTAEDSAGYLLAHLTPGLSVLDVGCGPGTITADLAARVAPGQVTAVD QAADVLEVARAEAEQRNLSNVSFGTADVHRLDFADDTFDVVHAHQVLQHLSDPVAALREMRRVCRPGGIV AVRDADYAGFIWYPELPALDLWRDLYRRVARANRGEPDAGRRLLSWARQAGFDDITPTGSLWCYATPETR DWWGGMWADRILHSTVARDLVSLGLAAREQLEEISAAWREWAAAPDGWIAIPHGEIICRA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0854 | - | - | 100% (270) | methyltransferase-UbiE family protein |
| M. avium 104 | MAV_3903 | - | 4e-12 | 26.74% (258) | methyltransferase, UbiE/COQ5 family protein |
| M. avium 104 | MAV_5229 | - | 3e-11 | 43.00% (100) | methyltransferase type 11 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0862 | - | 1e-123 | 75.19% (270) | hypothetical protein Mb0862 |
| M. gilvum PYR-GCK | Mflv_1845 | - | 3e-11 | 28.28% (198) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv0839 | - | 1e-123 | 75.19% (270) | hypothetical protein Rv0839 |
| M. leprae Br4923 | MLBr_01723 | - | 6e-10 | 28.15% (135) | hypothetical protein MLBr_01723 |
| M. abscessus ATCC 19977 | MAB_4742c | - | 4e-12 | 35.19% (108) | hypothetical protein MAB_4742c |
| M. marinum M | MMAR_4799 | - | 1e-116 | 71.00% (269) | hypothetical protein MMAR_4799 |
| M. smegmatis MC2 155 | MSMEG_0098 | - | 4e-15 | 41.46% (123) | methyltransferase |
| M. thermoresistible (build 8) | TH_3050 | - | 4e-11 | 29.59% (196) | PUTATIVE Methyltransferase type 12 |
| M. ulcerans Agy99 | MUL_0368 | - | 1e-116 | 71.38% (269) | hypothetical protein MUL_0368 |
| M. vanbaalenii PYR-1 | Mvan_4690 | - | 2e-13 | 36.03% (136) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1845|M.gilvum_PYR-GCK --------MATYDVPDAFDAGADAYDGLVGANPGYHKH------------
TH_3050|M.thermoresistible__bu -VTGRRRHLDRAAVPAAFDAGAASYDRLVAANPGYHEH------------
Mb0862|M.bovis_AF2122/97 ----------------MNDKRRAIYTHGYHESVLRSHR------------
Rv0839|M.tuberculosis_H37Rv ----------------MNDKRRAIYTHGYHESVLRSHR------------
MMAR_4799|M.marinum_M ----------------MNDERRAVYTHGHHESVLRGHR------------
MUL_0368|M.ulcerans_Agy99 ----------------MNDERRAVYTHGHHESVLRGHR------------
MAV_0854|M.avium_104 ----------------MNDQHRATYTHGHHESVLRSHR------------
MSMEG_0098|M.smegmatis_MC2_155 MDTALRRAMDLLIDPPAEPDFSKGYLDLLGRGDSTAPKNTGLIQKAWASP
Mvan_4690|M.vanbaalenii_PYR-1 ----MVDRANVAQVQAWNGDSGRAWVTLQHVLDRTLKP------------
MLBr_01723|M.leprae_Br4923 ----MTRSTEISANAVPNPHATAEQVAAARKDSKLAQVLYHDWEAENYDE
MAB_4742c|M.abscessus_ATCC_199 MTAPSANPVPETTEEFSERLTAAIDNAALVLLMSIGHQTGLLDTLAASAG
Mflv_1845|M.gilvum_PYR-GCK -------------LRLSARRMGLP---DGGRGLVLLDIGCGTGASTAALL
TH_3050|M.thermoresistible__bu -------------LRLSAHRMGLPGCAARXRGLRILDAGCGTGASTAALL
Mb0862|M.bovis_AF2122/97 -------------RRTAENSAGYLLP-YLVPGLSVLDVGCGPGTITVDLA
Rv0839|M.tuberculosis_H37Rv -------------RRTAENSAGYLLP-YLVPGLSVLDVGCGPGTITVDLA
MMAR_4799|M.marinum_M -------------QRTVANSAGYLSP-HLRAGLSVLDIGCGPGTITVDLA
MUL_0368|M.ulcerans_Agy99 -------------QRTVANSAGYLSP-HLRAGLSVLDIGCGPGTITVDLA
MAV_0854|M.avium_104 -------------RRTAEDSAGYLLA-HLTPGLSVLDVGCGPGTITADLA
MSMEG_0098|M.smegmatis_MC2_155 LGSKLYDRAQLLNRRLVASTRPPVEWLRIPPGGTVLDIGCGPGNITAQLA
Mvan_4690|M.vanbaalenii_PYR-1 ------------FEDLIVDSVAAAAG----PREQILDLGCGTGATTLALA
MLBr_01723|M.leprae_Br4923 KWSISYDQRCVDYVRHCFDAIVPDELFTELPYDCALELGCGTGFFLLNLI
MAB_4742c|M.abscessus_ATCC_199 STSEQLADAAGLEERYVREWLAGMTVAHVVDYEPVSAIYTLPSHRAATLT
.. *
Mflv_1845|M.gilvum_PYR-GCK RAA-PHAEIVAVDGSAGMLAQAR----AKRWPPNVRFVHSRVEDLAVNGV
TH_3050|M.thermoresistible__bu TYA-PDAEIVAVDASAGMLAAAA----AKPWPATVRFVHSRVEDLAGAGV
Mb0862|M.bovis_AF2122/97 ARV-VPGSVTGVEPTDDALSLAR----AEAQLHRLSNISFTTSDVHKLDF
Rv0839|M.tuberculosis_H37Rv ARV-VPGSVTGVEPTDDALSLAR----AEAQLHRLSNISFTTSDVHKLDF
MMAR_4799|M.marinum_M ARV-APATVTAVEPTDAALNLAR----AEVQRCDVSNVAFVTSDVHALDF
MUL_0368|M.ulcerans_Agy99 ARV-APGTVTAVEPTDAALNLGR----AEAQRCDVSNVAFVTSDVHALDF
MAV_0854|M.avium_104 ARV-APGQVTAVDQAADVLEVAR----AEAEQRNLSNVSFGTADVHRLDF
MSMEG_0098|M.smegmatis_MC2_155 RAAGLDGLALGVDISEPMLARAV----AAEAG---RQVGFVRADAQQLPF
Mvan_4690|M.vanbaalenii_PYR-1 ERLGAHGGCTGIDISEPMIHAAR----TRARDRN-LPVEFVVGDAQSFPF
MLBr_01723|M.leprae_Br4923 QSG-VARRGSVTDLSPGMVKIAT----RNGQSLG-LDINGRVADAEGIPY
MAB_4742c|M.abscessus_ATCC_199 REAGLNNLARLAQYLPLLSEVEQKILGCFRRGGGLQYQDYPRFHAVMGER
: .
Mflv_1845|M.gilvum_PYR-GCK TG-PFDGILAAYLIRNVADRDGVLQ----------------ELRALLRPG
TH_3050|M.thermoresistible__bu GG-PFDAVFAAYLLRNLPDPDTQLT----------------AFRDLLRPG
Mb0862|M.bovis_AF2122/97 PDDAFDVVHAHQVLQHVADPVRALQ----------------EMRRVCTPG
Rv0839|M.tuberculosis_H37Rv PDDAFDVVHAHQVLQHVADPVRALQ----------------EMRRVCTPG
MMAR_4799|M.marinum_M PDDVFDVVHAHQVLQHVADPVQALR----------------EMKRVCAPG
MUL_0368|M.ulcerans_Agy99 PDDVFDVVHAHQVLQHVADPVQALR----------------EMKRVGAPG
MAV_0854|M.avium_104 ADDTFDVVHAHQVLQHLSDPVAALR----------------EMRRVCRPG
MSMEG_0098|M.smegmatis_MC2_155 RDEVFDAATSLAVFQLIPDPVAAVS----------------EIVRVLKPG
Mvan_4690|M.vanbaalenii_PYR-1 QPNTFDVMVSRFGVMFFDDPTTAFR----------------NLRRATRPG
MLBr_01723|M.leprae_Br4923 DDNTFDLVVGHAVLHHIPDVELSLR----------------EVLRVLKPG
MAB_4742c|M.abscessus_ATCC_199 SREVFDKALIRTVLPLVEGLPEGLEGGLDVADFGCGSGYAINLMAQAFPA
** . . . . . *.
Mflv_1845|M.gilvum_PYR-GCK G---VFAAHEYSVR-----DSRTATALWNLVSSAVIIPAG-------RLR
TH_3050|M.thermoresistible__bu G---ILAVHEYSVR-----DSAVATAVWNVVCGAVVIPLG-------RLR
Mb0862|M.bovis_AF2122/97 G---IVAARDADYSGFIWFPKLPALDRWLDLYERAARANGGEPDAGRRLL
Rv0839|M.tuberculosis_H37Rv G---IVAARDADYSGFIWFPKLPALDRWLDLYERAARANGGEPDAGRRLL
MMAR_4799|M.marinum_M G---LVAARDADYAGFIWYPQLPALDHWLKLYQRAARANGGEPDAGRRLL
MUL_0368|M.ulcerans_Agy99 G---LVAARDADYAGFIWYPQLPALDHWLQLYQRAARANGGEPDAGRRLL
MAV_0854|M.avium_104 G---IVAVRDADYAGFIWYPELPALDLWRDLYRRVARANRGEPDAGRRLL
MSMEG_0098|M.smegmatis_MC2_155 G---RVAIMVPTAG------------------------------------
Mvan_4690|M.vanbaalenii_PYR-1 GRLTFVCWRDPTDNPFMSTAERAAAQLLSDLKPGIAGSPGPFAFADAHRT
MLBr_01723|M.leprae_Br4923 GR--FVFAGEPTDVGNRYARVFADLTWKVTIRVVQLPGLSAWRRTQVEID
MAB_4742c|M.abscessus_ATCC_199 SRFTGVDFSDEAIATAAADAERLGLRNASFLSADVATLNAPATYDLITAF
. .
Mflv_1845|M.gilvum_PYR-GCK -----------SGDAELYRYLKRSVNEFDG--------AAEFRNRLQR--
TH_3050|M.thermoresistible__bu -----------TGDAALYRYLRRSVNTFDG--------AERFRNRLRA--
Mb0862|M.bovis_AF2122/97 SWARAAGFDDVTPTASVWCFATASAREWWGLVWADRILQSDLAHQLVD--
Rv0839|M.tuberculosis_H37Rv SWARAAGFDDVTPTASVWCFATASAREWWGLVWADRILQSDLAHQLVD--
MMAR_4799|M.marinum_M SWARQAGFADITPTGSMWCYATDEMRAWWGGMWAERILRSDLSAQLLG--
MUL_0368|M.ulcerans_Agy99 SWARQAGFADITPTGSMWCYATDEMRAWWGGMWADRILRSDLSAQLLG--
MAV_0854|M.avium_104 SWARQAGFDDITPTGSLWCYATPETRDWWGGMWADRILHSTVARDLVS--
MSMEG_0098|M.smegmatis_MC2_155 -------------AVKPVTFLARGGARIFG--------DDELGDIFEN--
Mvan_4690|M.vanbaalenii_PYR-1 HSILRAGGWTAVDIRPVDVTCTMQESDLLPYLTQMGPVGRTLRAVDAR--
MLBr_01723|M.leprae_Br4923 ENSRAAALEWVVDLHTFEPKVLETMATNAGAVQVKTVTEEFTAAMLGWP-
MAB_4742c|M.abscessus_ATCC_199 DTIHDQAHP-AAVLANIHRALRPGGVLLMADIKASSRLEDNIGVAMSTYR
Mflv_1845|M.gilvum_PYR-GCK ------------NGFVDVT------------SHTMSGWQHDIVHTFLGRT
TH_3050|M.thermoresistible__bu ------------CGFTDVR------------SATMPGWQRDIVHTFLARR
Mb0862|M.bovis_AF2122/97 ------------SGLATAAQLEEISTAWREWAAAPDGWLAIPHGEILCRA
Rv0839|M.tuberculosis_H37Rv ------------SGLATAAQLEEISTAWREWAAAPDGWLAIPHGEILCRA
MMAR_4799|M.marinum_M ------------SGMASAADLEAISQAWRDWAAAPDGWLGIPNGEILCRV
MUL_0368|M.ulcerans_Agy99 ------------SGMASAADLEAISQAWRDWAAAPDGWLGIPNGEILCRV
MAV_0854|M.avium_104 ------------LGLAAREQLEEISAAWREWAAAPDGWIAIPHGEIICRA
MSMEG_0098|M.smegmatis_MC2_155 ------------VGLVGVR-------------VKTHGFIQWVRGTKL---
Mvan_4690|M.vanbaalenii_PYR-1 ------------TRAQVITSLREAYT-----EFIVDGEVRYPAACWMVDA
MLBr_01723|M.leprae_Br4923 -----------LRTFESTMPPSKLGWGWARFAFTSWKTLSWVDANVWRRV
MAB_4742c|M.abscessus_ATCC_199 YTVSLTHCMPVSLGLEGAGLGTMWGRQLAESMLAEAGFSDVTVREIEQDT
Mflv_1845|M.gilvum_PYR-GCK PQ---------------
TH_3050|M.thermoresistible__bu PG---------------
Mb0862|M.bovis_AF2122/97 -----------------
Rv0839|M.tuberculosis_H37Rv -----------------
MMAR_4799|M.marinum_M -----------------
MUL_0368|M.ulcerans_Agy99 -----------------
MAV_0854|M.avium_104 -----------------
MSMEG_0098|M.smegmatis_MC2_155 -----------------
Mvan_4690|M.vanbaalenii_PYR-1 RG---------------
MLBr_01723|M.leprae_Br4923 IPKSWFYNIIITGVKPS
MAB_4742c|M.abscessus_ATCC_199 SNYFYIARR--------