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AFTRIHSFLASAGNTSMYKRVWRFWYPLMTHKLGTDEIMFINWAYEEDPPMALPLEASDEPNRAHINLYH RTATQVNLSGKRILEVSCGHGGGASYLTRALHPASYTGLDLNPAGIKLCQKRHQLPGLEFVRGDAENLPF DNESFDVVINIEASHCYPHFPRFLAEVVRVLRPGGHLAYADLRPSNKVGEWEVDFANSRLQQLSQREINA EVLRGIASNSQKSRDLVDRHLPAFLRFAGREFIGVQGTQLSRYLEGGELSYRMYSFAKD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_00130 | - | - | 100% (270) | hypothetical protein MLBr_00130 |
| M. leprae Br4923 | MLBr_01723 | - | 1e-09 | 34.00% (100) | hypothetical protein MLBr_01723 |
| M. leprae Br4923 | MLBr_00551 | - | 4e-07 | 34.91% (106) | putative methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2976 | - | 1e-136 | 83.70% (270) | methyltransferase (methylase) |
| M. gilvum PYR-GCK | Mflv_4060 | - | 2e-11 | 36.52% (115) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv2952 | - | 1e-136 | 83.70% (270) | methyltransferase (methylase) |
| M. abscessus ATCC 19977 | MAB_4103c | - | 4e-79 | 56.47% (255) | methyltransferase |
| M. marinum M | MMAR_3170 | - | 1e-121 | 76.67% (270) | methyltransferase |
| M. avium 104 | MAV_2111 | - | 5e-10 | 33.96% (106) | methyltransferase, UbiE/COQ5 family protein |
| M. smegmatis MC2 155 | MSMEG_0393 | - | 5e-70 | 50.19% (257) | Fmt protein |
| M. thermoresistible (build 8) | TH_1636 | - | 2e-76 | 54.90% (255) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. ulcerans Agy99 | MUL_2377 | - | 1e-121 | 76.30% (270) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_0109 | - | 6e-11 | 37.00% (100) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2976|M.bovis_AF2122/97 MAFSRTHSLLARAGSTSTYKRVWRYWYPLMTRGLGNDEIVFINWAYEEDP
Rv2952|M.tuberculosis_H37Rv MAFSRTHSLLARAGSTSTYKRVWRYWYPLMTRGLGNDEIVFINWAYEEDP
MLBr_00130|M.leprae_Br4923 MAFTRIHSFLASAGNTSMYKRVWRFWYPLMTHKLGTDEIMFINWAYEEDP
MMAR_3170|M.marinum_M MAFSPAHRLLARMGSTSIYKRVWRYWYPLMTRGLGADKIAFLNWAYEEDP
MUL_2377|M.ulcerans_Agy99 MAFSPAHRLLARLGSTSIYKRVWRYWYPLMTRGLGADKIAFLNWAYEEDP
MSMEG_0393|M.smegmatis_MC2_155 ---MEARDRVAWRLNIKVAQQAQKLVYRYATRRLKDDDVVFLNYGYEEDP
TH_1636|M.thermoresistible__bu --VRESRDQVFRKLNEKLTQHGQKFIYSYASRRLDDDDVVFLNYGYEEDP
MAB_4103c|M.abscessus_ATCC_199 --MQRSRDWVMFKLNAVFTQRVQKFIYRHATRKLETEDVVFLNYGYEEEP
MAV_2111|M.avium_104 ---------------------------MTAPQRRGLNDVVTRMWSFLA-P
Mvan_0109|M.vanbaalenii_PYR-1 -MTHTVLRMTERLLIDPPEHPDTSKGYLDLLGDEPDSNRGAIQALWASRL
Mflv_4060|M.gilvum_PYR-GCK -----------------------------MATVDNEDDRALKAKHRALWA
..
Mb2976|M.bovis_AF2122/97 PMDLPLEASDEPNRAHINLYHRTATQVDLGGKQVLEVSCGHGGGASYLTR
Rv2952|M.tuberculosis_H37Rv PMDLPLEASDEPNRAHINLYHRTATQVDLGGKQVLEVSCGHGGGASYLTR
MLBr_00130|M.leprae_Br4923 PMALPLEASDEPNRAHINLYHRTATQVNLSGKRILEVSCGHGGGASYLTR
MMAR_3170|M.marinum_M PIDLTLEVSDEPNRDHINMYHRTATHVELSGKRVLEVSCGHGGGASYLTR
MUL_2377|M.ulcerans_Agy99 PIDLTLEVSDEPNRDHINMYHRTATHVELSGKRVLEVSCGHGGGASYLTR
MSMEG_0393|M.smegmatis_MC2_155 PMGIPLSESDELNRYSIQLYHSTAAQADVEGKRVLEVGCGHGGGASYLAR
TH_1636|M.thermoresistible__bu PMGLPLSETDEPNRYSIQLYHRTAGQADLTGKRVLEVGCGHGGGASYLMR
MAB_4103c|M.abscessus_ATCC_199 AMGVPLSASDEPDRYSIQLYHSTATQADLGGQRVLEVGCGHGGGASYLVR
MAV_2111|M.avium_104 AYDLPFLQQWVYRPPHN---EVIAQLRNHGSRRIADIACGTGILSERIQR
Mvan_0109|M.vanbaalenii_PYR-1 GSMFYDNAQTLARRLMTAWQQPTEWLNVPVGGTALDVGSGPGNVTGALGR
Mflv_4060|M.gilvum_PYR-GCK SGDYPAVAAELIPSLGPELVRACG---VRSGDRVLDVAAGSGN-ASIPAA
. . ::..* * :
Mb2976|M.bovis_AF2122/97 TLHPA-SYTGLDLNQAGIKLCKKRHRLPGLDFVRGDAENLPFDDESFDVV
Rv2952|M.tuberculosis_H37Rv TLHPA-SYTGLDLNQAGIKLCKKRHRLPGLDFVRGDAENLPFDDESFDVV
MLBr_00130|M.leprae_Br4923 ALHPA-SYTGLDLNPAGIKLCQKRHQLPGLEFVRGDAENLPFDNESFDVV
MMAR_3170|M.marinum_M TLHPA-SYTGLDLNRAGIKLCQRRHNLPGLDFVRGDAENLPFEDESFDVV
MUL_2377|M.ulcerans_Agy99 TLHPA-SYTGLDLNRAGIKLCQRRHNLPGLDFVRGDAENLPFEDESFDVV
MSMEG_0393|M.smegmatis_MC2_155 TFRPA-TYTGLDLNSDGINFCRRRHNIAGLEFVQGDAQDLPFPDKNFDAV
TH_1636|M.thermoresistible__bu TLGPM-SYVGLDLNPAGIEFCRKKHRLPGLEFVVGDAQDLPFGAESFDAV
MAB_4103c|M.abscessus_ATCC_199 ALQPA-SYTGLDLNPDGISFCRRRHDLPGLEFVQGDAEDLPFPDESFDAV
MAV_2111|M.avium_104 ELNPD-EIYGVDMSDG--MLNQARAKSDRVQWLRAPAEQLPFDDGALDAV
Mvan_0109|M.vanbaalenii_PYR-1 AVGPGGLALGVDISEPMLARAVRAEAGPNVGFIRADAQHLPFRDESFDAV
Mflv_4060|M.gilvum_PYR-GCK AAGAVVTASDLTPELFDAGRRIAAERGVAVEWVEADAEALPFPDDSFDVV
. .: . : :: . *: *** :*.*
Mb2976|M.bovis_AF2122/97 LNVEASHCYPHFRRFLAEVVRVLRPGGYFPYADLRPNNEIAAWEADLA--
Rv2952|M.tuberculosis_H37Rv LNVEASHCYPHFRRFLAEVVRVLRPGGYFPYADLRPNNEIAAWEADLA--
MLBr_00130|M.leprae_Br4923 INIEASHCYPHFPRFLAEVVRVLRPGGHLAYADLRPSNKVGEWEVDFA--
MMAR_3170|M.marinum_M LNVEASHCYPHFSRFLAEVVRVLRPGGYLLYTDLRPSNEIAEWEADLA--
MUL_2377|M.ulcerans_Agy99 LKVEASHCYPHFSRFLAEVVRVLRPGGYLLYTDLRPSNEIAEWEADLA--
MSMEG_0393|M.smegmatis_MC2_155 LNVESSHLYPRFDVFLTEVARVLRPGGYFLYTDARPRYDIPEWERALA--
TH_1636|M.thermoresistible__bu INIESSHLYPRFSRFLSEVARVLRPGGHFLYADARQPHEFAEWEAALA--
MAB_4103c|M.abscessus_ATCC_199 INVESSHLYPHFPVFLTEVARVLRPGGNFLYTDARSVQDVAGWKVALA--
MAV_2111|M.avium_104 VTTSAFHFFDQP-AALREFHRVLAPGGLVAVSALSTRRPLLQASADSR--
Mvan_0109|M.vanbaalenii_PYR-1 VSIAMLQLIPDPAVALAEMVRVLRPGRRMAVMVPTAG-PAAGLLRYLP--
Mflv_4060|M.gilvum_PYR-GCK MSCVGAMFAPHHQATADEIVRVTRPGGTLGLISWTPEGFIGHLFATMKPY
:. *. ** ** .
Mb2976|M.bovis_AF2122/97 -------ATPLRQLSQRQINAEVLRGIGNNSQKSRDLVDRHLPAFLRFAG
Rv2952|M.tuberculosis_H37Rv -------ATPLRQLSQRQINAEVLRGIGNNSQKSRDLVDRHLPAFLRFAG
MLBr_00130|M.leprae_Br4923 -------NSRLQQLSQREINAEVLRGIASNSQKSRDLVDRHLPAFLRFAG
MMAR_3170|M.marinum_M -------GSPLRQLSQREINAEVVRGIEKNSHTSRVLVDRNLPAFLRFAD
MUL_2377|M.ulcerans_Agy99 -------GSPLRQLSQREINAEVVRGIEKNSHTSRVLVDRNLPAFLRFAD
MSMEG_0393|M.smegmatis_MC2_155 -------DAPLQMLSQRAINFEVVRGMEKNLDALESVVDRVAPALLRDWI
TH_1636|M.thermoresistible__bu -------AAPLDMVSARVINAEVVRGMEQILPVWEDVIERVAPAFLRRRV
MAB_4103c|M.abscessus_ATCC_199 -------NAPLRMVSERGINAEVRRGMEKNLARWRYVIDRATPAPLRGIV
MAV_2111|M.avium_104 -------WKPQHNASAP----EMRKLFEDAGFVIGDQYRIPRPAWTRLVS
Mvan_0109|M.vanbaalenii_PYR-1 -------NAGAHAFGDD----ELGDTFESLGLAGVRINTVGTIQWVRGRK
Mflv_4060|M.gilvum_PYR-GCK APPPPPGASPPPMWGSENHVEALFGDRVRDLTMRRQTVRFDHCASPLDFR
. :
Mb2976|M.bovis_AF2122/97 REFIGVQGTQLSRYLEGGELSYRMYCFTKD--------------------
Rv2952|M.tuberculosis_H37Rv REFIGVQGTQLSRYLEGGELSYRMYCFTKD--------------------
MLBr_00130|M.leprae_Br4923 REFIGVQGTQLSRYLEGGELSYRMYSFAKD--------------------
MMAR_3170|M.marinum_M R----AVGRQLSRYLEGGELSYRMYCFTKDFAASR---------------
MUL_2377|M.ulcerans_Agy99 R----AVGRQLSRYLEGGELSYRMYCFTKDFAASR---------------
MSMEG_0393|M.smegmatis_MC2_155 QKY-GPARRAYEELR-ENTTEYRMYCFVKPAE------------------
TH_1636|M.thermoresistible__bu REF-APARRAWEELRTEGSTEYRMYCFTKPPEHADIP-------------
MAB_4103c|M.abscessus_ATCC_199 RRF-APAQRAYDDLRAGGSVEYRMYRFVKA--------------------
MAV_2111|M.avium_104 DLLTVGTKRD----------------------------------------
Mvan_0109|M.vanbaalenii_PYR-1 S-------------------------------------------------
Mflv_4060|M.gilvum_PYR-GCK EYWKRNYGPTLAAYRFNEDRPERLAELDAAFLDFLTTWNQADGTDGTAYD
Mb2976|M.bovis_AF2122/97 -----------
Rv2952|M.tuberculosis_H37Rv -----------
MLBr_00130|M.leprae_Br4923 -----------
MMAR_3170|M.marinum_M -----------
MUL_2377|M.ulcerans_Agy99 -----------
MSMEG_0393|M.smegmatis_MC2_155 -----------
TH_1636|M.thermoresistible__bu -----------
MAB_4103c|M.abscessus_ATCC_199 -----------
MAV_2111|M.avium_104 -----------
Mvan_0109|M.vanbaalenii_PYR-1 -----------
Mflv_4060|M.gilvum_PYR-GCK AEYLLVTATKR