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M. thermoresistible (build 8) TH_3395 (-)

annotation: putative ubiquinone/menaquinone biosynthesis methyltransferases
coordinates: 1936281 - 1936943
length: 221

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_3395--100% (221)putative ubiquinone/menaquinone biosynthesis methyltransferases
M. thermoresistible (build 8)TH_2189-4e-1036.28% (113) CONSERVED HYPOTHETICAL PROTEIN
M. thermoresistible (build 8)TH_0087-1e-0835.59% (118) methyltransferase type 11

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1440c-1e-1033.66% (101) putative methyltransferase
M. gilvum PYR-GCKMflv_4269-1e-0936.73% (98) methyltransferase type 11
M. tuberculosis H37RvRv1405c-1e-1033.66% (101) putative methyltransferase
M. leprae Br4923MLBr_00551-5e-1235.64% (101) putative methyltransferase
M. abscessus ATCC 19977MAB_4018-3e-1130.19% (159) similarity with UbiE/COQ5 methyltransferase
M. marinum MMMAR_1062-5e-1334.62% (156) methyltransferase
M. avium 104MAV_2988-1e-4947.27% (220) ubiquinone/menaquinone biosynthesis methyltransferases
M. smegmatis MC2 155MSMEG_0098-3e-1445.71% (105) methyltransferase
M. ulcerans Agy99MUL_0820-1e-1334.62% (156) methyltransferase
M. vanbaalenii PYR-1Mvan_2948-5e-1241.84% (98) methyltransferase type 11

CLUSTAL 2.0.9 multiple sequence alignment


TH_3395|M.thermoresistible__bu      --------------------MADVAANWAGRGGRFAG-GLYDFGVEREVL
MAV_2988|M.avium_104                --------------------MGQVTDHWR--AARLAS-ALYDTAAMHDRV
MMAR_1062|M.marinum_M               -----------------------MTNHHPRFGLQHSG-ESRDYLPAAGHD
MUL_0820|M.ulcerans_Agy99           -----------------------MTNHHPRFGLQHSG-ESRDYLPAAGHD
Mb1440c|M.bovis_AF2122/97           -----------------------MTIDTPAREDQTLA-ATHRAMWALGDY
Rv1405c|M.tuberculosis_H37Rv        -----------------------MTIDTPAREDQTLA-ATHRAMWALGDY
MLBr_00551|M.leprae_Br4923          -----------------------MNLYTPIHEDQSLA-AIHRAMWALGDY
MSMEG_0098|M.smegmatis_MC2_155      --MDTALRRAMDLLIDPPAEPDFSKGYLDLLGRGDST-APKNTGLIQKAW
MAB_4018|M.abscessus_ATCC_1997      MLHHPTLADSLIDPARIDHPPRRDHGYLDVLGPESDEPVSVANRFMQSPL
Mvan_2948|M.vanbaalenii_PYR-1       ---------------------MAPTNDQAARWNRYWD----KKSRTYDRE
Mflv_4269|M.gilvum_PYR-GCK          ------MTETKEPGAYPDVAVPAPTPHATKEQVEAALHDTKLAQVLYHDW
                                                                                      

TH_3395|M.thermoresistible__bu      ARPAGLLMWG--TDTRLLFDSIRRIG-------DLPDGT--AVLDIPCG-
MAV_2988|M.avium_104                AAVGAKALWG--LALRDLLAEVRHVG-------AAPPGA--YVLDIPCG-
MMAR_1062|M.marinum_M               ALLPAYDLLSRLLGMNKIHRTLITQA-------ELADCG--RILEIGCGT
MUL_0820|M.ulcerans_Agy99           ALLPAYDLLSRLLGMNKIHRTLITQA-------ELADCG--RILEIGCGT
Mb1440c|M.bovis_AF2122/97           ALMAEEVMAP-------LGPILVAAA-------GIGPGV--RVLDVAAGS
Rv1405c|M.tuberculosis_H37Rv        ALMAEEVMAP-------LGPILVAAA-------GIGPGV--RVLDVAAGS
MLBr_00551|M.leprae_Br4923          ALMAEEVMAP-------LGPILVTAT-------GIRPGM--QVLDVAAGS
MSMEG_0098|M.smegmatis_MC2_155      ASPLGSKLYDR---AQLLNRRLVASTRPPVEWLRIPPGG--TVLDIGCGP
MAB_4018|M.abscessus_ATCC_1997      LAAIYERAWRPMFTRGFSYGGKSTLKAHTALMDEIAGRGDHKILDVACGP
Mvan_2948|M.vanbaalenii_PYR-1       IGFFDRHLFGD-------SRQWVCS---------QATG---DVLEVAVG-
Mflv_4269|M.gilvum_PYR-GCK          EAETYDDKWSISYDQRCVDYARGRFDAAVP-EEVQRELPYDRALELGCGT
                                                                               *::  * 

TH_3395|M.thermoresistible__bu      GGLALR-GLRHGRRLRYVAADISADMLARAQRRAATLGRTD-VRFVVADI
MAV_2988|M.avium_104                GGFAFR-GLRAGQDCRYVAADISSDMLRRARSRATRFGVANLMEFTEADI
MMAR_1062|M.marinum_M               GNLAIK-AKRAQPRAEVIGSDPDPRALQRAQ--RKTGNV-EGVRFDQGYA
MUL_0820|M.ulcerans_Agy99           GNLAIK-AKRAQPRAEVIGSDPDPRALQRAQ--RKTGNV-EEVRFDQGYA
Mb1440c|M.bovis_AF2122/97           GNISLP-AAKTG--ATVISTDLTPELLQRSQ--ARAAQQGLTLQYQEANA
Rv1405c|M.tuberculosis_H37Rv        GNISLP-AAKTG--ATVISTDLTPELLQRSQ--ARAAQQGLTLQYQEANA
MLBr_00551|M.leprae_Br4923          GNISLP-AAKTG--ATIVSTDLTPELLQRSQ--ARATELGLTLEYREADA
MSMEG_0098|M.smegmatis_MC2_155      GNITAQLARAAGLDGLALGVDISEPMLARAV----AAEAGRQVGFVRADA
MAB_4018|M.abscessus_ATCC_1997      GLYTRELAAQLGTAGVCIGLDLSGPMLRRAVR----DNSAERVDYIRGSA
Mvan_2948|M.vanbaalenii_PYR-1       TGLNLN---FYPDDVALTGIDWSEQMLERAR--RRAAEIGRTATLQQADA
Mflv_4269|M.gilvum_PYR-GCK          GFFLLN-LIQAGVARRGSVTDLSPGMVKVATR--NGQSLGLDIDGRVADA
                                                        *     :  :                 .  

TH_3395|M.thermoresistible__bu      ERMPFGDGEFDCCVTFNGLHCVPDPAA--AVAEIARCVKPGGRLIGD---
MAV_2988|M.avium_104                TCLPFPDNTFDLALTFNGLHCLPDPRA--AVFELARVLKPGGILRGT---
MMAR_1062|M.marinum_M               QRLPYADGEFDRVLSSMMLHHLDEDAKSAAAAEAFRVLRPGGRLHLV---
MUL_0820|M.ulcerans_Agy99           QRLPYADGEFDRVLSSMMLHHLDEDAKSAAAAEAFRVLRPGGRLHLV---
Mb1440c|M.bovis_AF2122/97           QALPFADDEFDTVISAIGVMFAPDHQA--AADELVRVCRPGGTIGVI---
Rv1405c|M.tuberculosis_H37Rv        QALPFADDEFDTVISAIGVMFAPDHQA--AADELVRVCRPGGTIGVI---
MLBr_00551|M.leprae_Br4923          QALPFGDGEFDVVMSAIGVMFAPDHRR--AASELVRVCRPNGTIGVI---
MSMEG_0098|M.smegmatis_MC2_155      QQLPFRDEVFDAATSLAVFQLIPDPVA--AVSEIVRVLKPGGRVAIM---
MAB_4018|M.abscessus_ATCC_1997      HSLPFADATFDTVVCLAALYLIPDPEQ--AVRELCRVAGPDGQIVVF---
Mvan_2948|M.vanbaalenii_PYR-1       HHLPFEDASFDTVVCTFGLCAIPDHAQ--ALTEMARVLRPGGKLVLV---
Mflv_4269|M.gilvum_PYR-GCK          EGIPYEDNTFDLVVGHAVLHHIPDVEL--SLREVVRVLKPGGRFVFAGEP
                                      :*: *  **       .    :     :  *  *   *.* .      

TH_3395|M.thermoresistible__bu      AVVRGA--------------GRRQDALIAVFRRAGVFGPGGTTDELQ---
MAV_2988|M.avium_104                TCVRGR--------------GWRQDRFVTALQAAGFFGNTPGAGDVS---
MMAR_1062|M.marinum_M               DVGGD---------------MSAHDGLASRFIRHNLHVAGNLGDGIR---
MUL_0820|M.ulcerans_Agy99           DVGGD---------------MSAHDGLASRFIRHNLHVAGNLGDGIR---
Mb1440c|M.bovis_AF2122/97           SWTCEGFFGRMLATIRPYRPSVSADLPPSALWGREAYVTGLLGDGVTGLK
Rv1405c|M.tuberculosis_H37Rv        SWTCEGFFGRMLATIRPYRPSVSADLPPSALWGREAYVTGLLGDGVTGLK
MLBr_00551|M.leprae_Br4923          SWTQEGFFGRMLATIRPYRPSLSAALPPAALWGREAYIRGLLDDTVTNVK
MSMEG_0098|M.smegmatis_MC2_155      VPTAG----------------AVKPVTFLARGGARIFGDDELGDIFEN--
MAB_4018|M.abscessus_ATCC_1997      TSLRTR------------AASLPGVTTAMRIGGFRAFGRDEVTGWLR---
Mvan_2948|M.vanbaalenii_PYR-1       DHVQST------------AAPVRAVQRLLEVFTVPLAGEHFLRRPLS---
Mflv_4269|M.gilvum_PYR-GCK          TTVGNRYARELSTLTWHAATNIMKLPMLSDWRRPQAELDESSRAAALEAV
                                                                                      

TH_3395|M.thermoresistible__bu      ---GWLTRAGFEVEDFR-------RSGAVAHFTAVRS-------------
MAV_2988|M.avium_104                ---RWLGEAGLEIVAAR-------HSGSVELFEAVRPSA-----------
MMAR_1062|M.marinum_M               ---RLLDTAGFDVAEVG-----AQRHPLLGRLVYYRATRPCA--------
MUL_0820|M.ulcerans_Agy99           ---RLLDTAGFDVAEVG-----AQRHPLLGRLVYYRATRPCA--------
Mb1440c|M.bovis_AF2122/97           TARGLLEVKRFDTAQAVHDYFKNNYGPTIEAYAHIGDNAVLAAELDRQLV
Rv1405c|M.tuberculosis_H37Rv        TARGLLEVKRFDTAQAVHDYFKNNYGPTIEAYAHIGDNAVLAAELDRQLV
MLBr_00551|M.leprae_Br4923          TERRQLEVKRFNSAEGVHNYFKNHYGPTIEAYTNIGDNSVLAAELDAQLT
MSMEG_0098|M.smegmatis_MC2_155      -----VGLVGVRVKTHG-------------FIQWVRGTKL----------
MAB_4018|M.abscessus_ATCC_1997      ----AQGWTDIDQTVTG----------QGQFIRARRAVALRVAT------
Mvan_2948|M.vanbaalenii_PYR-1       ---HIRSATGLEIDRVER-----FKLGLVERLVAHKPVAP----------
Mflv_4269|M.gilvum_PYR-GCK          VDLHTFDPADLERMAANAG-AVEVRTASEEFTAAMLGWPVRTFEAAVPPG
                                              .                                       

TH_3395|M.thermoresistible__bu      ---------------------------------------------
MAV_2988|M.avium_104                ---------------------------------------------
MMAR_1062|M.marinum_M               ---------------------------------------------
MUL_0820|M.ulcerans_Agy99           ---------------------------------------------
Mb1440c|M.bovis_AF2122/97           ELAAQYLSDGVMEWEYLLLTAEKR---------------------
Rv1405c|M.tuberculosis_H37Rv        ELAAQYLSDGVMEWEYLLLTAEKR---------------------
MLBr_00551|M.leprae_Br4923          ELAQKYLTNSTMGWEYLLLTAQKH---------------------
MSMEG_0098|M.smegmatis_MC2_155      ---------------------------------------------
MAB_4018|M.abscessus_ATCC_1997      ---------------------------------------------
Mvan_2948|M.vanbaalenii_PYR-1       ---------------------------------------------
Mflv_4269|M.gilvum_PYR-GCK          RLGWGWAKFAFGSWTTLSWVDANVWRRIVPKGWFYNVMVTGVKPS