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MWDPDVYLAFSGHRNRPFYELVSRVGLERARRVVDLGCGPGHLTRYLARRWPGAVIEALDSSPEMVAAAA ERGIDATTGDLRDWKPKPDTDVVVSNAALHWVPEHSDLLVRWVDELAPGSWIAVQIPGNFETPSHAAVRA LARREPYAKLMRDIPFRVGAVVQSPAYYAELLMDTGCKVDVWETTYLHQLTGEHPVLDWITGSALVPVRE RLSDESWQQFRQELIPLLNDAYPPRADGSTIFPFRRLFMVAEVGGARRSGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0294 | tam | - | 100% (261) | PROBABLE TRANS-ACONITATE METHYLTRANSFERASE TAM |
| M. tuberculosis H37Rv | Rv0089 | - | 5e-06 | 35.14% (111) | methyltransferase/methylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0302 | tam | 1e-155 | 100.00% (261) | trans-aconitate methyltransferase tam |
| M. gilvum PYR-GCK | Mflv_0316 | - | 8e-99 | 65.22% (253) | trans-aconitate 2-methyltransferase |
| M. leprae Br4923 | MLBr_00130 | - | 7e-05 | 25.31% (162) | hypothetical protein MLBr_00130 |
| M. abscessus ATCC 19977 | MAB_2845 | - | 7e-52 | 42.69% (260) | trans-aconitate methyltransferase |
| M. marinum M | MMAR_0553 | tam | 1e-131 | 83.78% (259) | trans-aconitate methyltransferase Tam |
| M. avium 104 | MAV_4859 | - | 1e-132 | 83.66% (257) | trans-aconitate 2-methyltransferase |
| M. smegmatis MC2 155 | MSMEG_0629 | - | 2e-96 | 61.26% (253) | trans-aconitate 2-methyltransferase |
| M. thermoresistible (build 8) | TH_3050 | - | 3e-05 | 33.98% (103) | PUTATIVE Methyltransferase type 12 |
| M. ulcerans Agy99 | MUL_1216 | tam | 1e-128 | 81.47% (259) | trans-aconitate methyltransferase Tam |
| M. vanbaalenii PYR-1 | Mvan_0425 | - | 1e-100 | 63.64% (253) | trans-aconitate 2-methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0294|M.tuberculosis_H37Rv --------MWDPDVYLAFSGHRNRPFYELVSRVGLERARRVVDLGCG---
Mb0302|M.bovis_AF2122/97 --------MWDPDVYLAFSGHRNRPFYELVSRVGLERARRVVDLGCG---
MMAR_0553|M.marinum_M --------MWDPDVYLAFADHRGRPFYDLVSRIGAKRARRVVDLGCG---
MUL_1216|M.ulcerans_Agy99 --------MWDPAVYLAFADHRGRPFYDLVSRIGAKRARRVVDLGCG---
MAV_4859|M.avium_104 --------MWDPDVYLAFADHRARPFYDLLSRVGAERARRVVDLGCG---
Mflv_0316|M.gilvum_PYR-GCK --------MWNPAVYLTYADHRGRPYYDLLSRVDAREPRRIVDLGCG---
MSMEG_0629|M.smegmatis_MC2_155 --------MWNPETYLNFADHRGRPFFELLARIGARTPRRVVDLGCG---
Mvan_0425|M.vanbaalenii_PYR-1 --------MWDPDVYLNFADHRGRPFFDLLARVGADRPHRVVDLGCG---
MAB_2845|M.abscessus_ATCC_1997 -MTRTPKTQWSPQEYSRFGDERSRPFFELLARVQAVDPRTVVDLGCA---
TH_3050|M.thermoresistible__bu --------------VTGRRRHLDRAAVPAAFDAGAASYDRLVAANPG---
MLBr_00130|M.leprae_Br4923 MAFTRIHSFLASAGNTSMYKRVWRFWYPLMTHKLGTDEIMFINWAYEEDP
. * .:
Rv0294|M.tuberculosis_H37Rv PGHLTRYLARRWPGAVIEALDSSPEMVAAAAE---RGIDATTGDLRDWKP
Mb0302|M.bovis_AF2122/97 PGHLTRYLARRWPGAVIEALDSSPEMVAAAAE---RGIDATTGDLRDWKP
MMAR_0553|M.marinum_M PGNLTRYLARRWPEAIIEAWDSSPQMVAAARE---RGIDATTGDLRTWKP
MUL_1216|M.ulcerans_Agy99 PGNLTRYLARRWPEAIIEAWDSSPQMVAAARE---RGIDATTGDLRTWKP
MAV_4859|M.avium_104 PGHLTKYLGRRWPDAVIEAMDSSPEMVAAAKE---RGIDAVTGDLRNWKP
Mflv_0316|M.gilvum_PYR-GCK PGNLTRTLTQRWPGAVVEAWDSSEEMVTAARE---RGVDARVGDVRDWAP
MSMEG_0629|M.smegmatis_MC2_155 PGNLTETLTQRWPGAQVEALDSSPEMVAAARE---RGVDARVGAIEDWQP
Mvan_0425|M.vanbaalenii_PYR-1 PGNLTEVLGRRWPDAQVQGWDSSPEMVAAARG---RGVDARLGDIADWVP
MAB_2845|M.abscessus_ATCC_1997 SGVLTLELARRWPNASVLGLDSSAELLATAPADLPANVRLEQGDIADFRA
TH_3050|M.thermoresistible__bu YHEHLRLSAHRMGLPGCAARXRGLRILDAGCG-----TGASTAALLTYAP
MLBr_00130|M.leprae_Br4923 PMALPLEASDEPNRAHINLYHRTATQVNLSGKR-ILEVSCGHGGGASYLT
. . : . . : .
Rv0294|M.tuberculosis_H37Rv KPDTDVVVSNAALHWVPEHS--DLLVRWVDELAPGSWIAVQIPG-NFETP
Mb0302|M.bovis_AF2122/97 KPDTDVVVSNAALHWVPEHS--DLLVRWVDELAPGSWIAVQIPG-NFETP
MMAR_0553|M.marinum_M KPDTDVVISSAALHWVPEHA--DLMVQWATELPHGSWIAVQVPG-NFETP
MUL_1216|M.ulcerans_Agy99 KPDTDVVISSAALHWVPEHA--DLMVQWATVLPHGSWIAVQVPG-NFETP
MAV_4859|M.avium_104 KPDTDVVVSNAALHWVPEHS--DLLLRWAGQLAPGSWIGVQMPG-NFESP
Mflv_0316|M.gilvum_PYR-GCK LPDTDVVVSNATLHWVPEHP--DLLLRWAGQLRAGSWIAFQVPG-NFDAP
MSMEG_0629|M.smegmatis_MC2_155 TPDTDVVISNAALQWVPSHR--ELIVAWVQSLPAGAWLAFQVPG-NFDSP
Mvan_0425|M.vanbaalenii_PYR-1 EPDTDVVIANAALQWVPEHR--DLLVRWAGQLEPGSWIAFQVAG-NFDAP
MAB_2845|M.abscessus_ATCC_1997 DG-VDVVFTNAALQWLPQHR--DLISAWAHQLNPGGWLALQVPG-NFGAP
TH_3050|M.thermoresistible__bu DAEIVAVDASAGMLAAAAAKPWPATVRFVHSR-VEDLAGAGVGG-PFDAV
MLBr_00130|M.leprae_Br4923 RALHPASYTGLDLNPAGIKLCQKRHQLPGLEFVRGDAENLPFDNESFDVV
. :. : . . *
Rv0294|M.tuberculosis_H37Rv -SHAAVRALARREPYAKLMRDIPFRVGAVVQSPAYYAELLMDTGCKVDVW
Mb0302|M.bovis_AF2122/97 -SHAAVRALARREPYAKLMRDIPFRVGAVVQSPAYYAELLMDTGCKVDVW
MMAR_0553|M.marinum_M -SHAVVRALARREPYAKLMRDIPFRVGAVVGSPASYAGLLMDAGCKVDAW
MUL_1216|M.ulcerans_Agy99 -SHAVVRALARREPYAKLVRDIPFRVGAVVGSPASYAGLLMDAGCKVDAW
MAV_4859|M.avium_104 -SYAAVRALARREPYAKLLRDIPFRVGAVVQPPTHYANMLLDAGCKVDVW
Mflv_0316|M.gilvum_PYR-GCK -SHRAVRDLVSSARWAHLLRDFPFEKSEVVRPAAGYAELLTDAGCTVDAW
MSMEG_0629|M.smegmatis_MC2_155 -SHRAVRTVARSEAFADALRDMPWRDAHQVDDPLDYAGLLTDAGCTVDAW
Mvan_0425|M.vanbaalenii_PYR-1 -SHAAIREVARREPFTAALADMPWRDADVVGAPVEYAGLLTDAGCTVDAW
MAB_2845|M.abscessus_ATCC_1997 -SHALMRQVAESPRWAARLAGV-LRGTDSTDGAEDYARLAISSGLVPDAW
TH_3050|M.thermoresistible__bu FAAYLLRNLPDPDTQLTAFRDLLRPGG--ILAVHEYS--VRDSAVATAVW
MLBr_00130|M.leprae_Br4923 INIEASHCYPHFPRFLAEVVRVLRPGGHLAYADLRPSNKVGEWEVDFANS
: . . : .
Rv0294|M.tuberculosis_H37Rv ETTYLHQLTGEHPVLDWITGSALVP-VRERLSDESWQQFRQELIPLLNDA
Mb0302|M.bovis_AF2122/97 ETTYLHQLTGEHPVLDWITGSALVP-VRERLSDESWQQFRQELIPLLNDA
MMAR_0553|M.marinum_M ETTYLHQLTGKNPVLEWITGTALVP-VRERLDDVSWEQFRQELIPLLDDA
MUL_1216|M.ulcerans_Agy99 DPTYLHQLTGKNPVLEWITGTALVP-VRERFDDVSWEQFRQELIPLLDDA
MAV_4859|M.avium_104 ETTYLHQLTGEHPVLEWITGTALVP-VRERLDDDAWEQFREELIPLLRDA
Mflv_0316|M.gilvum_PYR-GCK ETTYVHELTGEKPVLEWIGGTALRP-VRAALPDHDWQEFRAELIPLLDAA
MSMEG_0629|M.smegmatis_MC2_155 ETTYVHELTGETPVLDWITGTALTQ-VRSRLDDTAWQRYREAIIPLLAEA
Mvan_0425|M.vanbaalenii_PYR-1 ETTYVHELVGETPVLDWITGTALTQ-VRQRLSDDAWERYRQAIIPLLAQA
MAB_2845|M.abscessus_ATCC_1997 ETTYVHLLGGDDPVLRWVHGTGLRP-VISALTADEFAEFESEYGALLRRA
TH_3050|M.thermoresistible__bu NVVCGAVVI---PLGRLRTGDAALY-RYLRRSVNTFDG-AERFRNRLRAC
MLBr_00130|M.leprae_Br4923 RLQQLSQREINAEVLRGIASNSQKSRDLVDRHLPAFLRFAGREFIGVQGT
: . . : :
Rv0294|M.tuberculosis_H37Rv YPPRADGSTIFPFRRLFMVAEVGGARRSGG--
Mb0302|M.bovis_AF2122/97 YPPRADGSTIFPFRRLFMVAEVGGARRSGG--
MMAR_0553|M.marinum_M YPPRSDGTTMFPFRRLFIVAEVGGARRSADVS
MUL_1216|M.ulcerans_Agy99 YPPRSDGTTMFPFRRLFIVAEVGGARRSADVS
MAV_4859|M.avium_104 YPPRADGTTIFPFRRVFIVAEVGSGRPAA---
Mflv_0316|M.gilvum_PYR-GCK YPRRADGITFFPFRRIFVVARVKN--------
MSMEG_0629|M.smegmatis_MC2_155 YPRRPDGITFFPFRRVFVVAQIR---------
Mvan_0425|M.vanbaalenii_PYR-1 YPVRSDGRTFFSFRRVFVVAQVT---------
MAB_2845|M.abscessus_ATCC_1997 YP-RSGDITPFGFRRIFCVASKPDGAR-----
TH_3050|M.thermoresistible__bu GFTDVRSATMPGWQRDIVHTFLARRPG-----
MLBr_00130|M.leprae_Br4923 QLSRYLEGGELSYRMYSFAKD-----------
::