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RVMTMNGRRRRAHDKLAALPGVRPVRRPVRPGVGDADEKFDVYYVRTGRKSAHPLVIIPGGPGAASIALY RAFRRRAAVAGLDVIMVEHRGVGLSRHDDSGADLPPEALTVDAAVDDIAAVLDDAQVERASVYGTSYGSY LAAGVGVRHPGRVQSMVLDSPLLSADDIDAVRAQTRRVLWDGADLAPRMRRLAADGVLRSEDVLLAIGLY ELAGPEGLGRQLDLLLARRDWLWRVAESVTKLVTERKTAYRHEPDLVERIAYRELNYGAVPDGGPLDPSV ALRQMATGDVDFVAEPYDLTSEMPGFAWPTVVVSGGRDLTTPPEVARRIADLIPDAALLELPTAGHSILD TREHAALRICEAVQAGQSHDLPSRSTELDALPANLTVRLLVRAITVAARAESAVPGAIPRVVRQLATS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4434 | - | - | 100% (419) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_1240 | - | 8e-08 | 30.07% (143) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_0113 | - | 5e-07 | 23.67% (169) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1935c | lipJ | 6e-05 | 32.46% (114) | lignin peroxidase LIPJ |
| M. gilvum PYR-GCK | Mflv_2257 | - | 0.0 | 79.51% (410) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv1900c | lipJ | 3e-05 | 30.77% (182) | lignin peroxidase LIPJ |
| M. leprae Br4923 | MLBr_01899 | lipG | 1e-08 | 28.38% (148) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_0139c | - | 1e-05 | 30.58% (121) | alpha/beta fold family hydrolase |
| M. marinum M | MMAR_4140 | - | 1e-131 | 59.38% (421) | hydrolase |
| M. avium 104 | MAV_1430 | - | 1e-121 | 55.88% (417) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_4998 | - | 1e-123 | 58.72% (407) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_1861 | lipG | 2e-09 | 32.19% (146) | PROBABLE LIPASE/ESTERASE LIPG |
| M. ulcerans Agy99 | MUL_4838 | lipJ | 2e-06 | 32.74% (113) | lignin peroxidase LipJ |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1935c|M.bovis_AF2122/97 ----------------MAQAPHIHRTRYAKCG-------DMDIAYQVLGD
Rv1900c|M.tuberculosis_H37Rv ----------------MAQAPHIHRTRYAKCG-------DMDIAYQVLGD
MUL_4838|M.ulcerans_Agy99 ----------------MSQAPRTPRTRYARCG-------DLDIAYQVIGD
MLBr_01899|M.leprae_Br4923 ---------------------MEVRSGYATSG-------DLKLYYEDMGN
TH_1861|M.thermoresistible__bu ---------------------MQIRTGFANVDG---SPEPVDLYYEDLGD
Mvan_4434|M.vanbaalenii_PYR-1 MRVMTMNGRRRRAHDKLAALPGVRPVRRPVRPGVGDADEKFDVYYVRTGR
Mflv_2257|M.gilvum_PYR-GCK MSVMTMNARRRRVHDRLAALPGVRPVRRPVHPG---ADGHFDVFYVRTGR
MMAR_4140|M.marinum_M ---MTMSDKRRRAHEKLAGMPGVRPVRRPVSPG---NDSEFDLYYVRAGR
MAV_1430|M.avium_104 ---MTMNAKRRRMQQRLAKLPGVRAVRRPISPD---TADEFDLYYVRAGR
MSMEG_4998|M.smegmatis_MC2_155 ------MANHGRKHATLAALPGVRAVRRPVAPG---ADEQFDVFYVRAGR
MAB_0139c|M.abscessus_ATCC_199 ----------------------MTSARFTFRGD--------TLAYSRTGT
. : * *
Mb1935c|M.bovis_AF2122/97 GPTDLLVLPGPFVPIDSIDDEPSLYR---FHRRLASFSRVIRLDHRGVGL
Rv1900c|M.tuberculosis_H37Rv GPTDLLVLPGPFVPIDSIDDEPSLYR---FHRRLASFSRVIRLDHRGVGL
MUL_4838|M.ulcerans_Agy99 HPIDLLVIPGASIPVDTIDSEPSMYR---FHRRLASFSRLIRFDHRGVGL
MLBr_01899|M.leprae_Br4923 ------VDDPPVLLIMGLGAQLVLWRTAFCEKLVAQGLRVVRYDNRDVGL
TH_1861|M.thermoresistible__bu ------PADPPVLLIMGLGAQLILWRDGFCRKLVERGLRVIRFDNRDVGL
Mvan_4434|M.vanbaalenii_PYR-1 K-----SAHPLVIIPGGPGAASIALYRAFRRRAAVAGLDVIMVEHRGVGL
Mflv_2257|M.gilvum_PYR-GCK K-----SAHPLVVIPGGPGAASIALYRSFRRHAAVAGLDVIMVEHRGVGL
MMAR_4140|M.marinum_M K-----SAHPLVIIPGGPGVASMLVYKGLRRRAAAAGLDVIMIEHRGVGM
MAV_1430|M.avium_104 K-----SRHPVVIIPGGPGVASVQMYKGLRRRAAAAGLDVIMIEHRGVGM
MSMEG_4998|M.smegmatis_MC2_155 K-----SRHPVVLIPGGPGVASIQQYRGLRRRLATSGLDVIMVEHRGIGM
MAB_0139c|M.abscessus_ATCC_199 G--------PPILFLHNGGSAKEIWTR--QVEVLRQRYEVICLDHLGYGE
: . . :: :: . *
Mb1935c|M.bovis_AF2122/97 SSRLAA-----ITTLGPKFWAQDAIAVMDAVGCEQATIFAPSFHAMNGLV
Rv1900c|M.tuberculosis_H37Rv SSRLAA-----ITTLGPKFWAQDAIAVMDAVGCEQATIFAPSFHAMNGLV
MUL_4838|M.ulcerans_Agy99 SSRVSS-----PDALGPRFWAEDAIAVMDAAGCQQATILASGFTATTALV
MLBr_01899|M.leprae_Br4923 SSRTDS-----TEQP-----------------CPSQPLTARLIRFWLGQR
TH_1861|M.thermoresistible__bu SSKLDG-----RRE--------------------RTPLPWRMLRSFAGLP
Mvan_4434|M.vanbaalenii_PYR-1 SRHDDSGADLPPEALTVDAAVDDIAAVLDDAQVERASVYGTSYGSYLAAG
Mflv_2257|M.gilvum_PYR-GCK SRHDDDGADLPPEALTVDAAVGDIAAVLDDAGVERAVVYGASYGSYLAAG
MMAR_4140|M.marinum_M SRHDDSGADLPPEAFTIDQVVDDIAAVLDDAHVDSAVIYGTSYGTYIAAG
MAV_1430|M.avium_104 SRHDDAGADLPPEAMTVNQVVDDVAAVLDDARVDSAVVYGASYGTYIASG
MSMEG_4998|M.smegmatis_MC2_155 SRRTDAGADLPAEAITVEQVLDDIAAVLDDAGVGTAVVYGTSYGSYLASG
MAB_0139c|M.abscessus_ATCC_199 SDMPERG-------------------------------------------
*
Mb1935c|M.bovis_AF2122/97 LAADYPERVRSLIVVNGSARPLWAPDYPVGAQVRRADPFLTVALEPDAVE
Rv1900c|M.tuberculosis_H37Rv LAADYPERVRSLIVVNGSARPLWAPDYPVGAQVRRADPFLTVALEPDAVE
MUL_4838|M.ulcerans_Agy99 LAADYPERVRSLVLINASARTLHAPDYELGIRSNTAEPFLTLGTDPDAVE
MLBr_01899|M.leprae_Br4923 NACAY-----------------------------------TLEDMTDDAV
TH_1861|M.thermoresistible__bu SPAVY-----------------------------------TLEDMADDAA
Mvan_4434|M.vanbaalenii_PYR-1 VGVRHPGRVQSMVLDSP----------------------LLSADDIDAVR
Mflv_2257|M.gilvum_PYR-GCK VGVRHPGRIHAMVLDSP----------------------LLSAHDIDAVR
MMAR_4140|M.marinum_M VGVRHPARVRSMILDSP----------------------LLSRDDIALAR
MAV_1430|M.avium_104 VGVRHPARVHGMVLDSP----------------------LLSRHDIVIVR
MSMEG_4998|M.smegmatis_MC2_155 VGVRHPGRVAAMVLDSP----------------------VLSAHDLDEMR
MAB_0139c|M.abscessus_ATCC_199 ---------------------------------------YTIDQHVERLS
Mb1935c|M.bovis_AF2122/97 QGFDVLSIVAPTVAGDDVFRAWWDLAGNRAGPPSMARAVSKVIAEADVR-
Rv1900c|M.tuberculosis_H37Rv RGFDVLSIVAPTVAGDDVFRAWWDLAGNRAGPPSIARAVSKVIAEADVR-
MUL_4838|M.ulcerans_Agy99 QGFDVLRIMAPSVAHDDAFRHWWDLAGNRAASPSTARAFINAVQASDAR-
MLBr_01899|M.leprae_Br4923 ALLDHLSIERAHIVGASMGGMIAQIFAARFPTRTRS---LAVFFSSNNR-
TH_1861|M.thermoresistible__bu GLLDHLQIDAAHIVGASMGGMVAQVFAGRHAHRTRS---LGVIFSSNNR-
Mvan_4434|M.vanbaalenii_PYR-1 AQTRRVLWDG-----ADLAPRMRRLAADGVLRSEDVLLAIGLYELAGPEG
Mflv_2257|M.gilvum_PYR-GCK AQTRRVLWED-----TDLAPRVRTLADEGALTPQDVLLMIGLYELAGPQV
MMAR_4140|M.marinum_M ETIRRRLLDGDSPETAALAAKVRQLVDAGVMTARASQVAAAVYGYGGARL
MAV_1430|M.avium_104 RAIRRLLLRGDSPETASLAPKMRKLVDAGLMTATATQVVATIYGYGGARL
MSMEG_4998|M.smegmatis_MC2_155 TAIRNLLWEGTGPDTAALAPKVRKLVETGRLTG--GQLAGLLYGYGGARL
MAB_0139c|M.abscessus_ATCC_199 AFIEHLGHERISVVGNCMGSAMALLLADRRPELFDSLVLINPLSKNTAR-
: .
Mb1935c|M.bovis_AF2122/97 --DVLGHIEAPTLILHRVGSTYIPVGHGRYLAEHIAGSRLVELPGTDTLY
Rv1900c|M.tuberculosis_H37Rv --DVLGHIEAPTLILHRVGSTYIPVGHGRYLAEHIAGSRLVELPGTDTLY
MUL_4838|M.ulcerans_Agy99 --DSLPHITAPTLILHRVGTKFVPVEHGRYLAEHIAGSRLVELPGSDSLY
MLBr_01899|M.leprae_Br4923 --PFLPPPAPRALLALLTG----PPTGSRRDVVVDNVVRVTKITGS-PLY
TH_1861|M.thermoresistible__bu --PFLPPPGPRQLLSIITG----PAPDAPRDEVIENAVKVGRLNGS-PAY
Mvan_4434|M.vanbaalenii_PYR-1 LGRQLDLLLARRDWLWRVAESVTKLVTERKTAYRHEPDLVERIAYRELNY
Mflv_2257|M.gilvum_PYR-GCK LRRQLDLRVADRNRLWKIAERVTRLVTERKTPYHHEPDLVERIAYQELNY
MMAR_4140|M.marinum_M LERQLDLLLCGRMILWHVLFRFSAMY-ARKVPYRYEMDLVGRIAFRELDY
MAV_1430|M.avium_104 LERQLDLLLDGRKLLWWTLSRFTTL---RNLPFRYEEDLVSRIALRELDY
MSMEG_4998|M.smegmatis_MC2_155 LDRQLDLLLDGHTLLWRTLGRLGRVS-TRKAPYRNEIDLVGRIAFRELNY
MAB_0139c|M.abscessus_ATCC_199 -----RGVLGWLLPLVSRFPTLSMAISRRVRIPQALTNIVITVQFGPRNW
: : :
Mb1935c|M.bovis_AF2122/97 WVGDTGPMLDEIEEFITGVRGGADAERMLATIMFTDIVGSTQHAAALGDD
Rv1900c|M.tuberculosis_H37Rv WVGDTGPMLDEIEEFITGVRGGADAERMLATIMFTDIVGSTQHAAALGDD
MUL_4838|M.ulcerans_Agy99 WVGDTAALLDEVEEFITGVRGGFVTERVLTAVMFTGIVGSTQRAATVGDL
MLBr_01899|M.leprae_Br4923 RMPEEQVRTNAAEIYDR---------------SFYPLGVSRQFSAILGS-
TH_1861|M.thermoresistible__bu PVPDEQLRADAATAFDR---------------SYHPVGVARQFDAILGS-
Mvan_4434|M.vanbaalenii_PYR-1 GAVPDGGPLDPSVALRQMATGD---VDFVAEPYDLTSEMPGFAWPTVVVS
Mflv_2257|M.gilvum_PYR-GCK GAVPDGGPVDPAVALREMASGT---VEFVGEPYDLPAAMPGFGWPTAVLS
MMAR_4140|M.marinum_M AAEPDGLPLDPAQAIRETIAAT---DQFESEPYDLVAEMPRFGWPTVVVS
MAV_1430|M.avium_104 AAEPDGLPLDPAVAEREVRTQT---ATFEDEPYDLPAEMPSFDWPTAVVS
MSMEG_4998|M.smegmatis_MC2_155 AGVPDGLPLDPALEMAEMARATKFHEPFEAEPYDLTAEMPKFTWPTVVVS
MAB_0139c|M.abscessus_ATCC_199 LRGIRAPRPGTAQAGKGWSVRG-------------RLAALAEMFCDQTSL
.
Mb1935c|M.bovis_AF2122/97 RWRDLLDNHDTIVCHEIQRFGGREVNTAGDGFVATFTSPSAAIACADDIV
Rv1900c|M.tuberculosis_H37Rv RWRDLLDNHDTIVCHEIQRFGGREVNTAGDGFVATFTSPSAAIACADDIV
MUL_4838|M.ulcerans_Agy99 RWRDLLDNHDNLVRHEIQRFGGREVNTAGDGFVATFSSPSAAINCADAVV
MLBr_01899|M.leprae_Br4923 --GSLLHYNQRIIAPTVVIHGR----------ADKLVRPSSGRAVARAIT
TH_1861|M.thermoresistible__bu --GSLRRYNRRTTSPTVVIHGR----------ADKLMRPTGGRAVARAIP
Mvan_4434|M.vanbaalenii_PYR-1 GGRDLTTPPEVARRIADLIPDAALLELPTAGHSILDTREHAALRICEAVQ
Mflv_2257|M.gilvum_PYR-GCK GGRDLTTPPEVARRVADLIPDSVLVSLPTAGHSVLDIRERAAVEICKAVC
MMAR_4140|M.marinum_M GGHDLTTPAMVAEHIASLLPNAVLIELPTMAHSALDFREPAALAIAGAVC
MAV_1430|M.avium_104 GGRDLITPPAVAERVASLLPHAVLLSLPDMAHSALDFHEAVALASADAVL
MSMEG_4998|M.smegmatis_MC2_155 GGRDLITPPALAQRVASLIPGATPVCMATAAHSIVDTRERAAIAIMQAVC
MAB_0139c|M.abscessus_ATCC_199 GAVDEIRPGPDFPPFAVIWGDS-----------NLGLSPRAGRALNRTLQ
. . :
Mb1935c|M.bovis_AF2122/97 DAVAALGIEVRIGIHAGEVEVRDASHGTDVAGVAVHIGARVCALAGPSEV
Rv1900c|M.tuberculosis_H37Rv DAVAALGIEVRIGIHAGEVEVRDASHGTDVAGVAVHIGARVCALAGPSEV
MUL_4838|M.ulcerans_Agy99 DAVAVLGIEVRVGIHAGEVEVR----GADVADLAVHIGARVCALAGSSEV
MLBr_01899|M.leprae_Br4923 -------------------------------------GARLVLFDGMGHD
TH_1861|M.thermoresistible__bu -------------------------------------GARLTLFDGMGHD
Mvan_4434|M.vanbaalenii_PYR-1 AG------------------------------QSHDLPSRSTELDALPAN
Mflv_2257|M.gilvum_PYR-GCK SG------------------------------ELHELPSRAAELDALPAN
MMAR_4140|M.marinum_M RG------------------------------EFGALTGRGEELDAMPAR
MAV_1430|M.avium_104 RG------------------------------DLAGLAARACTLNALPPR
MSMEG_4998|M.smegmatis_MC2_155 NG------------------------------AAEQLPHTADELDALPPR
MAB_0139c|M.abscessus_ATCC_199 PD----------------------------------REEFLTRCGHLPMM
Mb1935c|M.bovis_AF2122/97 LVSSTVRDIVAGSRHRFAERGEQELKGVPGRWRLCVLMRDDATRTR
Rv1900c|M.tuberculosis_H37Rv LVSSTVRDIVAGSRHRFAERGEQELKGVPGRWRLCVLMRDDATRTR
MUL_4838|M.ulcerans_Agy99 LVSSTVRDIVTGSSHRFAERGEHELKGVPGRWRLCALVREHLTGQR
MLBr_01899|M.leprae_Br4923 LPQQLWDQAVGVLMSNFAKAS-------------------------
TH_1861|M.thermoresistible__bu LPEPLWDEIVAELDKNITAGR-------------------------
Mvan_4434|M.vanbaalenii_PYR-1 LTVRLLVRAITVAARAESAVPGAIPRVVRQLATS------------
Mflv_2257|M.gilvum_PYR-GCK LTVRLLVGAITVAARAESAVPGSAP----TAPTS------------
MMAR_4140|M.marinum_M LPIRALWKAIELAAMAEHALPAAPLLHRRVSSA-------------
MAV_1430|M.avium_104 PEVRLLWALIAAAAMIEGALPIPAPLRRRLSCG-------------
MSMEG_4998|M.smegmatis_MC2_155 MPIRLLVAAISAAVAAEGMADSVLPATS------------------
MAB_0139c|M.abscessus_ATCC_199 ESPEEVTAIITEFIARPPARRLGDLATSPGSA--------------
: