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QIRSGTAKSGDLDIFYEDMGDPNDPAVLLIMGLGAQLLLWRNGFCEKLINQGLRVIRFDNRDVGLSSKLH HHRSGAPLLPRMARSFVGRPSPAAYTLEDMADDAAALLDHLGIDTAHVVGGSMGGMIAQVFAARHRARTG ALGVIFSSNNQAALPPPGPRQLAAILQRPKGSDREAIIENAVRVSRIIGSPGYPAAEERLRADAIEGYDR SYYPAGVGRHFAAILGSGSLRRYDRQITAPTVVIHGTADKLMRPSGGRAIARAIPRARLVLFDGMGHELP EPLWDDIVGELKTTFAEIS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1240 | - | - | 100% (300) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_0113 | - | 1e-54 | 43.12% (276) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_0592 | - | 2e-10 | 27.68% (289) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0665c | lipG | 1e-111 | 65.89% (299) | lipase/esterase LipG |
| M. gilvum PYR-GCK | Mflv_5112 | - | 1e-152 | 88.59% (298) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv0646c | lipG | 1e-111 | 65.89% (299) | lipase/esterase LipG |
| M. leprae Br4923 | MLBr_01899 | lipG | 1e-104 | 61.51% (304) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_3880 | - | 6e-98 | 59.87% (299) | lipase/esterase LipG |
| M. marinum M | MMAR_0981 | lipG1 | 1e-109 | 63.14% (312) | lipase/esterase LipG1 |
| M. avium 104 | MAV_4515 | - | 1e-118 | 69.44% (301) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_1352 | - | 1e-122 | 70.07% (304) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_1861 | lipG | 1e-116 | 69.36% (297) | PROBABLE LIPASE/ESTERASE LIPG |
| M. ulcerans Agy99 | MUL_0733 | lipG1 | 1e-108 | 62.82% (312) | lipase/esterase LipG1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1240|M.vanbaalenii_PYR-1 -----MQIRSGTAKS-------------GDLDIFYEDMGDPNDPAVLLIM
Mflv_5112|M.gilvum_PYR-GCK -----MQVRTGTARS-------------GELEIHYEDMGDPNDPAVLLIM
MSMEG_1352|M.smegmatis_MC2_155 -----MQTRTGLARAG---------DADHPIDLFYEDMGDPGDPAVLLIM
TH_1861|M.thermoresistible__bu -----MQIRTGFANVD---------GSPEPVDLYYEDLGDPADPPVLLIM
Mb0665c|M.bovis_AF2122/97 -----MDIRSGTAVS-------------GDVKLYYEDMGDLDHPPVLLIM
Rv0646c|M.tuberculosis_H37Rv -----MDIRSGTAVS-------------GDVKLYYEDMGDLDHPPVLLIM
MAV_4515|M.avium_104 ----MVQVRTGHAIS-------------GDLKLYYEDMGDIDDPPVLLIM
MMAR_0981|M.marinum_M -----MEIRTGYAQSGVGSGATSERQPAGDLKLYYEDMGDINAPPVLLIM
MUL_0733|M.ulcerans_Agy99 -----MEIRTGYAQSGVGSGATSERQPAGDLKLYYEDMGDINAPPVLLIM
MLBr_01899|M.leprae_Br4923 -----MEVRSGYATS-------------GDLKLYYEDMGNVDDPPVLLIM
MAB_3880|M.abscessus_ATCC_1997 MSTTAREISEMTASTAT----------VGDIELCYEEFGNPADPAVLLIM
: * :.: **::*: *.*****
Mvan_1240|M.vanbaalenii_PYR-1 GLGAQLLLWRNGFCEKLINQGLRVIRFDNRDVGLSSKLH---HHRSGAPL
Mflv_5112|M.gilvum_PYR-GCK GLGAQLLLWRKGFCEKLINQGLRVIRFDNRDVGLSSKLT---GHHAGAPL
MSMEG_1352|M.smegmatis_MC2_155 GLGAQMLMWRTEFCEKLVDQGLRVIRFDNRDVGLSTKLS---GQRVDSPL
TH_1861|M.thermoresistible__bu GLGAQLILWRDGFCRKLVERGLRVIRFDNRDVGLSSKLD---GRRERTPL
Mb0665c|M.bovis_AF2122/97 GLGAQMLLWRTDFCARLVAKGLRVIRYDNRDVGLSTKTE---RHRPGQPL
Rv0646c|M.tuberculosis_H37Rv GLGAQMLLWRTDFCARLVAKGLRVIRYDNRDVGLSTKTE---RHRPGQPL
MAV_4515|M.avium_104 GLGAQLLLWRTAFCEKLVGRGLRVIRYDNRDVGLSSKTE---HRSSGQPL
MMAR_0981|M.marinum_M GLGAQLLLWRTGFCQKLVDQGLRVIRYDNRDVGLSTKME---QPSARQPL
MUL_0733|M.ulcerans_Agy99 GLGAQLLLWRTGFCQKPVDQGLRVIRYDNRDVGLSTKME---QPSARQPL
MLBr_01899|M.leprae_Br4923 GLGAQLVLWRTAFCEKLVAQGLRVVRYDNRDVGLSSRTDSTEQPCPSQPL
MAB_3880|M.abscessus_ATCC_1997 GIGAQMVFWRPEFCQQLADQGYRVIRFDNRDCGLSTKLDG--VRAGGGSL
*:***:::** ** : :* **:*:**** ***:: .*
Mvan_1240|M.vanbaalenii_PYR-1 LPRMARSFVGRPSP-AAYTLEDMADDAAALLDHLGIDTAHVVGGSMGGMI
Mflv_5112|M.gilvum_PYR-GCK LPRMARSLAGLPSP-AAYTLEDMADDAAALLDHLDIDRAHVVGGSMGGMI
MSMEG_1352|M.smegmatis_MC2_155 ALRMARSFLGKRSP-AVYTLEDMADDAAALLDHLEIDRAHIVGGSMGGMI
TH_1861|M.thermoresistible__bu PWRMLRSFAGLPSP-AVYTLEDMADDAAGLLDHLQIDAAHIVGASMGGMV
Mb0665c|M.bovis_AF2122/97 ATRLVRSWLGLPSQ-AAYTLEDMAADAAALLDHLDVKHAHVVGASMGGMI
Rv0646c|M.tuberculosis_H37Rv ATRLVRSWLGLPSQ-AAYTLEDMAADAAALLDHLDVKHAHVVGASMGGMI
MAV_4515|M.avium_104 VTRLLRSWLGLPSQ-SAYRLEDMADDAAAVLDHLGIDDAHIVGASMGGMI
MMAR_0981|M.marinum_M MPQLIRSWLGRRSQ-TPYTLEDMADDAAALLDHLDIERAHIVGASMGGMI
MUL_0733|M.ulcerans_Agy99 MPQLIRSWLGRRSQ-TPYTLEDMADDAAALLDHLDIERAHIVGASMGGMI
MLBr_01899|M.leprae_Br4923 TARLIRFWLGQRNA-CAYTLEDMTDDAVALLDHLSIERAHIVGASMGGMI
MAB_3880|M.abscessus_ATCC_1997 IPSMAKFLAGVKITGTAYTLVDMAGDAAGLLDHLGIEQAHIVGASMGGMI
: : * * * **: **..:**** :. **:**.*****:
Mvan_1240|M.vanbaalenii_PYR-1 AQVFAARHRARTGALGVIFSSNNQAALPPPGPRQLAAILQRP-KGSDREA
Mflv_5112|M.gilvum_PYR-GCK AQVFAARHHPRTKTLGVIFSSNNQAALPPPGPRQLAAILQRP-KGSSRDE
MSMEG_1352|M.smegmatis_MC2_155 AQVFASQHAARTETLGVIFSSNNQALLPPPGIRQLLSLITGPPADASRDA
TH_1861|M.thermoresistible__bu AQVFAGRHAHRTRSLGVIFSSNNRPFLPPPGPRQLLSIITGPAPDAPRDE
Mb0665c|M.bovis_AF2122/97 AQIFAARFAQRTKTLAVIFSSNNHRFLPPPAPRALLALLTGPPPDSPRDV
Rv0646c|M.tuberculosis_H37Rv AQIFAARFAQRTKTLAVIFSSNNHRFLPPPAPRALLALLTGPPPDSPRDV
MAV_4515|M.avium_104 AQIFAARFRQRTKTLAVIFSSNNSALLPPPAPRALLALLKGPPPDSPREV
MMAR_0981|M.marinum_M AQIFAARFAERTNSLAVIFSSNNRPFLPPPAPRALLAVLNGPPPGSPREV
MUL_0733|M.ulcerans_Agy99 AQIFAARFAERTNSLAVIFSSNNRPFLPPPAPRALLAVLNGPPPGSPREV
MLBr_01899|M.leprae_Br4923 AQIFAARFPTRTRSLAVFFSSNNRPFLPPPAPRALLALLTGPPTGSRRDV
MAB_3880|M.abscessus_ATCC_1997 AQVFAAEHPDRTATVSIIMSSNNQPFLPPPGPRQLMALLKPPPEGASREQ
**:**... ** ::.:::**** ****. * * ::: * .: *:
Mvan_1240|M.vanbaalenii_PYR-1 IIENAVRVSRIIGSPGYPAAEERLRADAIEGYDRSYYPAGVGRHFAAILG
Mflv_5112|M.gilvum_PYR-GCK IVDNAVRVSRIIGSPGYPAPLDRLRTDAIEGFDRSYYPAGVGRHFAAILG
MSMEG_1352|M.smegmatis_MC2_155 VLDNAVRLSRLNGSPAYPRSEEEIRAEAAELYDRAYYPAGIARHFAAILG
TH_1861|M.thermoresistible__bu VIENAVKVGRLNGSPAYPVPDEQLRADAATAFDRSYHPVGVARQFDAILG
Mb0665c|M.bovis_AF2122/97 IVDNAVRVSKIIGSPAYPIPEDQVRAEAAESYDRNFHPWGIAQQFSAILG
Rv0646c|M.tuberculosis_H37Rv IVDNAVRVSKIIGSPAYPIPEDQVRAEAAESYDRNFHPWGIAQQFSAILG
MAV_4515|M.avium_104 IIDNAVRVGRIIGSTRYRVPEEQARAEAAEGYDRNYYPQGVARHFSAVLG
MMAR_0981|M.marinum_M IIDNVVRVTRITGSPGYQPTEEWIRADAAENYDRSYYPWGIPRQFSAVLG
MUL_0733|M.ulcerans_Agy99 IIDNVVRVTRITGSPGYQPTEEWIRADAAENYDRSYYPWGIPRQFSAVLG
MLBr_01899|M.leprae_Br4923 VVDNVVRVTKITGSPLYRMPEEQVRTNAAEIYDRSFYPLGVSRQFSAILG
MAB_3880|M.abscessus_ATCC_1997 IIANSVQVGRIIGSPKYRQSQSKSYLHAAEYYDRSYYPKGFSRQFAAIMG
:: * *:: :: **. * . . .* :** ::* *. ::* *::*
Mvan_1240|M.vanbaalenii_PYR-1 SGSLRRYDRQITAPTVVIHGTADKLMRPSGGRAIARAIPRARLVLFDGMG
Mflv_5112|M.gilvum_PYR-GCK SGSLRRYDRQITAPTVVIHGRADKLMRPSGGRAIARAIPGARLVLFDGMG
MSMEG_1352|M.smegmatis_MC2_155 SGSLRHHNERVTAPTVVIHGRADRLMPPSGGRAIANAIRGARMVLIDGMG
TH_1861|M.thermoresistible__bu SGSLRRYNRRTTSPTVVIHGRADKLMRPTGGRAVARAIPGARLTLFDGMG
Mb0665c|M.bovis_AF2122/97 SGSLLRYDRRIVAPTVVIHGRADKLMRPFGGRAVARAINGARLVLIDGMG
Rv0646c|M.tuberculosis_H37Rv SGSLLRYDRRIVAPTVVIHGRADKLMRPFGGRAVARAINGARLVLIDGMG
MAV_4515|M.avium_104 SGSLRRYNRRTTAPTVVIHGRADKLMRPFGGRAVAGAIDGARLVLFDGMG
MMAR_0981|M.marinum_M SGSLLGYNRRTVAPTVVIHGRADKLMRPFGGRAVAKAINGARMVEFDGMG
MUL_0733|M.ulcerans_Agy99 SGSLLGYNRRTVAPTVVIHGRADKLMRPFGGRAVAKAINGARMVEFDGMG
MLBr_01899|M.leprae_Br4923 SGSLLHYNQRIIAPTVVIHGRADKLVRPSSGRAVARAITGARLVLFDGMG
MAB_3880|M.abscessus_ATCC_1997 TGSLAPFDNRITAPALVLHGKADKLMRPSGARAIARAIPGSRLALIDGMG
:*** .:.: :*::*:** **:*: * ..**:* ** :*:. :****
Mvan_1240|M.vanbaalenii_PYR-1 HELPEPLWDDIVGELKTTFAEIS-------------
Mflv_5112|M.gilvum_PYR-GCK HDLPEPLWDDIVGELKTTFAEAP-------------
MSMEG_1352|M.smegmatis_MC2_155 HELPEPVWDEVIGELKTNFAVVG-------------
TH_1861|M.thermoresistible__bu HDLPEPLWDEIVAELDKNITAGR-------------
Mb0665c|M.bovis_AF2122/97 HDLPRQLWDRVIGELTRNFSEAG-------------
Rv0646c|M.tuberculosis_H37Rv HDLPRQLWDRVIGELTRNFSEAG-------------
MAV_4515|M.avium_104 HDLPQQLWDQVIGVLANNFAKAS-------------
MMAR_0981|M.marinum_M HDLPRQLWDQVIGVLTSNFEQAK-------------
MUL_0733|M.ulcerans_Agy99 HDLPRQLWDQVIGVLTSNFEQAE-------------
MLBr_01899|M.leprae_Br4923 HDLPQQLWDQAVGVLMSNFAKAS-------------
MAB_3880|M.abscessus_ATCC_1997 HDLPEPLWNHIITKLTENFARSEPAAETPESEAAGR
*:**. :*: : * .: