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MSVMTMNARRRRVHDRLAALPGVRPVRRPVHPGADGHFDVFYVRTGRKSAHPLVVIPGGPGAASIALYRS FRRHAAVAGLDVIMVEHRGVGLSRHDDDGADLPPEALTVDAAVGDIAAVLDDAGVERAVVYGASYGSYLA AGVGVRHPGRIHAMVLDSPLLSAHDIDAVRAQTRRVLWEDTDLAPRVRTLADEGALTPQDVLLMIGLYEL AGPQVLRRQLDLRVADRNRLWKIAERVTRLVTERKTPYHHEPDLVERIAYQELNYGAVPDGGPVDPAVAL REMASGTVEFVGEPYDLPAAMPGFGWPTAVLSGGRDLTTPPEVARRVADLIPDSVLVSLPTAGHSVLDIR ERAAVEICKAVCSGELHELPSRAAELDALPANLTVRLLVGAITVAARAESAVPGSAPTAPTS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2257 | - | - | 100% (412) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_5264 | - | 2e-07 | 21.45% (303) | alpha/beta hydrolase fold |
| M. gilvum PYR-GCK | Mflv_1348 | - | 6e-07 | 23.96% (313) | 3-oxoadipate enol-lactonase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1935c | lipJ | 0.0001 | 27.62% (181) | lignin peroxidase LIPJ |
| M. tuberculosis H37Rv | Rv3617 | ephA | 6e-05 | 28.68% (129) | epoxide hydrolase EphA |
| M. leprae Br4923 | MLBr_01899 | lipG | 4e-06 | 25.90% (139) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_3880 | - | 6e-06 | 28.79% (132) | lipase/esterase LipG |
| M. marinum M | MMAR_4140 | - | 1e-129 | 57.25% (407) | hydrolase |
| M. avium 104 | MAV_1430 | - | 1e-127 | 57.46% (409) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_4998 | - | 1e-125 | 58.33% (408) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_1861 | lipG | 3e-05 | 29.20% (137) | PROBABLE LIPASE/ESTERASE LIPG |
| M. ulcerans Agy99 | MUL_4838 | lipJ | 5e-06 | 31.25% (128) | lignin peroxidase LipJ |
| M. vanbaalenii PYR-1 | Mvan_4434 | - | 0.0 | 79.51% (410) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2257|M.gilvum_PYR-GCK MSVMTMNARRRRVHDRLAALPGVRPVRRPVHPG---ADGHFDVFYVRTGR
Mvan_4434|M.vanbaalenii_PYR-1 MRVMTMNGRRRRAHDKLAALPGVRPVRRPVRPGVGDADEKFDVYYVRTGR
MMAR_4140|M.marinum_M ---MTMSDKRRRAHEKLAGMPGVRPVRRPVSPG---NDSEFDLYYVRAGR
MAV_1430|M.avium_104 ---MTMNAKRRRMQQRLAKLPGVRAVRRPISPD---TADEFDLYYVRAGR
MSMEG_4998|M.smegmatis_MC2_155 ------MANHGRKHATLAALPGVRAVRRPVAPG---ADEQFDVFYVRAGR
MLBr_01899|M.leprae_Br4923 --------------------MEVRSGYATSG--------DLKLYYEDMGN
TH_1861|M.thermoresistible__bu --------------------MQIRTGFANVDGS----PEPVDLYYEDLGD
MAB_3880|M.abscessus_ATCC_1997 ------------MSTTAREISEMTASTATVG--------DIELCYEEFGN
Mb1935c|M.bovis_AF2122/97 ----------------MAQAPHIHRTRYAKCG-------DMDIAYQVLGD
MUL_4838|M.ulcerans_Agy99 ----------------MSQAPRTPRTRYARCG-------DLDIAYQVIGD
Rv3617|M.tuberculosis_H37Rv --------------------MGAPTERLVDTNG-------VRLRVVEAGE
. : *
Mflv_2257|M.gilvum_PYR-GCK KSAHPLVVIPGGPGAASIALYRSFR--RHAAVAGLDVIMVEHRGVGLSRH
Mvan_4434|M.vanbaalenii_PYR-1 KSAHPLVIIPGGPGAASIALYRAFR--RRAAVAGLDVIMVEHRGVGLSRH
MMAR_4140|M.marinum_M KSAHPLVIIPGGPGVASMLVYKGLR--RRAAAAGLDVIMIEHRGVGMSRH
MAV_1430|M.avium_104 KSRHPVVIIPGGPGVASVQMYKGLR--RRAAAAGLDVIMIEHRGVGMSRH
MSMEG_4998|M.smegmatis_MC2_155 KSRHPVVLIPGGPGVASIQQYRGLR--RRLATSGLDVIMVEHRGIGMSRR
MLBr_01899|M.leprae_Br4923 VDDPPVLLIMG-LGAQLVLWRTAFC--EKLVAQGLRVVRYDNRDVGLSSR
TH_1861|M.thermoresistible__bu PADPPVLLIMG-LGAQLILWRDGFC--RKLVERGLRVIRFDNRDVGLSSK
MAB_3880|M.abscessus_ATCC_1997 PADPAVLLIMG-IGAQMVFWRPEFC--QQLADQGYRVIRFDNRDCGLSTK
Mb1935c|M.bovis_AF2122/97 GPTDLLVLPGPFVPIDSIDDEPSLYRFHRRLASFSRVIRLDHRGVGLSSR
MUL_4838|M.ulcerans_Agy99 HPIDLLVIPGASIPVDTIDSEPSMYRFHRRLASFSRLIRFDHRGVGLSSR
Rv3617|M.tuberculosis_H37Rv PGAPVVILAHGFPELAYS-WRHQIP---ALADAGYHVLAPDQRGYGGSSR
::: : :: ::*. * * :
Mflv_2257|M.gilvum_PYR-GCK DD-------------------DGADLPPEALTVDAAVGDIAAVLDDAGVE
Mvan_4434|M.vanbaalenii_PYR-1 DD-------------------SGADLPPEALTVDAAVDDIAAVLDDAQVE
MMAR_4140|M.marinum_M DD-------------------SGADLPPEAFTIDQVVDDIAAVLDDAHVD
MAV_1430|M.avium_104 DD-------------------AGADLPPEAMTVNQVVDDVAAVLDDARVD
MSMEG_4998|M.smegmatis_MC2_155 TD-------------------AGADLPAEAITVEQVLDDIAAVLDDAGVG
MLBr_01899|M.leprae_Br4923 TDSTEQPCPSQPLTARLIRFWLGQRNA-CAYTLEDMTDDAVALLDHLSIE
TH_1861|M.thermoresistible__bu LDGRRE---RTPLPWRMLRSFAGLPSP-AVYTLEDMADDAAGLLDHLQID
MAB_3880|M.abscessus_ATCC_1997 LDGVRAG--GGSLIPSMAKFLAGVKITGTAYTLVDMAGDAAGLLDHLGIE
Mb1935c|M.bovis_AF2122/97 LA------------------------AITTLGPKFWAQDAIAVMDAVGCE
MUL_4838|M.ulcerans_Agy99 VS------------------------SPDALGPRFWAEDAIAVMDAAGCQ
Rv3617|M.tuberculosis_H37Rv PE------------------------AIEAYDIHRLTADLVGLLDDVGAE
. . * .::*
Mflv_2257|M.gilvum_PYR-GCK RAVVYGASYGSYLAAGVGVRHPGRIHAMVLDSPLLSAHDIDAVRAQTRRV
Mvan_4434|M.vanbaalenii_PYR-1 RASVYGTSYGSYLAAGVGVRHPGRVQSMVLDSPLLSADDIDAVRAQTRRV
MMAR_4140|M.marinum_M SAVIYGTSYGTYIAAGVGVRHPARVRSMILDSPLLSRDDIALARETIRRR
MAV_1430|M.avium_104 SAVVYGASYGTYIASGVGVRHPARVHGMVLDSPLLSRHDIVIVRRAIRRL
MSMEG_4998|M.smegmatis_MC2_155 TAVVYGTSYGSYLASGVGVRHPGRVAAMVLDSPVLSAHDLDEMRTAIRNL
MLBr_01899|M.leprae_Br4923 RAHIVGASMGGMIAQIFAARFPTRTRSLAVFFSSNNRPFLPPPAPRALLA
TH_1861|M.thermoresistible__bu AAHIVGASMGGMVAQVFAGRHAHRTRSLGVIFSSNNRPFLPPPGPRQLLS
MAB_3880|M.abscessus_ATCC_1997 QAHIVGASMGGMIAQVFAAEHPDRTATVSIIMSSNNQPFLPPPGPRQLMA
Mb1935c|M.bovis_AF2122/97 QATIFAPSFHAMNGLVLAADYPERVRSLIVVNGSARPLWAPDYPVGAQVR
MUL_4838|M.ulcerans_Agy99 QATILASGFTATTALVLAADYPERVRSLVLINASARTLHAPDYELGIRSN
Rv3617|M.tuberculosis_H37Rv RAVWVGHDWGAVVVWNAPLLHADRVAAVAALSVPALPRAQVPPTQAFRSR
* . . .. * :
Mflv_2257|M.gilvum_PYR-GCK LWED-----TDLAPRVR--TLADEGALTPQDVLLMIGLYELAGPQVLRRQ
Mvan_4434|M.vanbaalenii_PYR-1 LWDG-----ADLAPRMR--RLAADGVLRSEDVLLAIGLYELAGPEGLGRQ
MMAR_4140|M.marinum_M LLDGDSPETAALAAKVR--QLVDAGVMTARASQVAAAVYGYGGARLLERQ
MAV_1430|M.avium_104 LLRGDSPETASLAPKMR--KLVDAGLMTATATQVVATIYGYGGARLLERQ
MSMEG_4998|M.smegmatis_MC2_155 LWEGTGPDTAALAPKVR--KLVETGRLTG--GQLAGLLYGYGGARLLDRQ
MLBr_01899|M.leprae_Br4923 LLTG-----PPTGSRRD--VVVDN--------------------------
TH_1861|M.thermoresistible__bu IITG-----PAPDAPRD--EVIEN--------------------------
MAB_3880|M.abscessus_ATCC_1997 LLKP-----PPEGASRE--QIIAN--------------------------
Mb1935c|M.bovis_AF2122/97 RADPFLTVALEPDAVEQGFDVLSIVAPTVAGDDVFRAWWDLAGNRAGPPS
MUL_4838|M.ulcerans_Agy99 TAEPFLTLGTDPDAVEQGFDVLRIMAPSVAHDDAFRHWWDLAGNRAASPS
Rv3617|M.tuberculosis_H37Rv FGENFFYILYFQEPGIADAELNGDPARTMR-----------RMIGGLRPP
. :
Mflv_2257|M.gilvum_PYR-GCK LDLRVADRNRLWKIAERVTRLVTERKTPYHHEPDLVERIAYQELNYGAV-
Mvan_4434|M.vanbaalenii_PYR-1 LDLLLARRDWLWRVAESVTKLVTERKTAYRHEPDLVERIAYRELNYGAV-
MMAR_4140|M.marinum_M LDLLLCGRMILWHVLFRFSAMY-ARKVPYRYEMDLVGRIAFRELDYAAE-
MAV_1430|M.avium_104 LDLLLDGRKLLWWTLSRFTTL---RNLPFRYEEDLVSRIALRELDYAAE-
MSMEG_4998|M.smegmatis_MC2_155 LDLLLDGHTLLWRTLGRLGRVS-TRKAPYRNEIDLVGRIAFRELNYAGV-
MLBr_01899|M.leprae_Br4923 --------------VVRVTKIT--GSPLYRMPEEQVRTNAAEIYDRSFY-
TH_1861|M.thermoresistible__bu --------------AVKVGRLN--GSPAYPVPDEQLRADAATAFDRSYH-
MAB_3880|M.abscessus_ATCC_1997 --------------SVQVGRII--GSPKYRQSQSKSYLHAAEYYDRSYY-
Mb1935c|M.bovis_AF2122/97 MARAVSKVIAEADVRDVLGHIEAPTLILHRVGSTYIPVGHGRYLAEHIAG
MUL_4838|M.ulcerans_Agy99 TARAFINAVQASDARDSLPHITAPTLILHRVGTKFVPVEHGRYLAEHIAG
Rv3617|M.tuberculosis_H37Rv GDQSAAMRMLAPGPDGFIDRLPEPAGLPAWISQEELDHYIGEFTRTGFTG
. :
Mflv_2257|M.gilvum_PYR-GCK -----------------------------------PDGGPVDPAVALREM
Mvan_4434|M.vanbaalenii_PYR-1 -----------------------------------PDGGPLDPSVALRQM
MMAR_4140|M.marinum_M -----------------------------------PDGLPLDPAQAIRET
MAV_1430|M.avium_104 -----------------------------------PDGLPLDPAVAEREV
MSMEG_4998|M.smegmatis_MC2_155 -----------------------------------PDGLPLDPALEMAEM
MLBr_01899|M.leprae_Br4923 -----------------------------------PLG----VSRQFSAI
TH_1861|M.thermoresistible__bu -----------------------------------PVG----VARQFDAI
MAB_3880|M.abscessus_ATCC_1997 -----------------------------------PKG----FSRQFAAI
Mb1935c|M.bovis_AF2122/97 SRLVELPGTDTLYWVGDTGPMLDEIEEFITGVRGGADAERMLATIMFTDI
MUL_4838|M.ulcerans_Agy99 SRLVELPGSDSLYWVGDTAALLDEVEEFITGVRGGFVTERVLTAVMFTGI
Rv3617|M.tuberculosis_H37Rv ---------------------------------------GLNWYRNFDRN
Mflv_2257|M.gilvum_PYR-GCK ASGT---VEFVGEPY-DLPAAMPGFGWPTAVLSGGRDLTTP---------
Mvan_4434|M.vanbaalenii_PYR-1 ATGD---VDFVAEPY-DLTSEMPGFAWPTVVVSGGRDLTTP---------
MMAR_4140|M.marinum_M IAAT---DQFESEPY-DLVAEMPRFGWPTVVVSGGHDLTTP---------
MAV_1430|M.avium_104 RTQT---ATFEDEPY-DLPAEMPSFDWPTAVVSGGRDLITP---------
MSMEG_4998|M.smegmatis_MC2_155 ARATKFHEPFEAEPY-DLTAEMPKFTWPTVVVSGGRDLITP---------
MLBr_01899|M.leprae_Br4923 LGSG------------SLLHYNQRIIAPTVVIHGRADKLVR---------
TH_1861|M.thermoresistible__bu LGSG------------SLRRYNRRTTSPTVVIHGRADKLMR---------
MAB_3880|M.abscessus_ATCC_1997 MGTG------------SLAPFDNRITAPALVLHGKADKLMR---------
Mb1935c|M.bovis_AF2122/97 VGSTQHAAALGDDRWRDLLDNHDTIVCHEIQRFGGREVNTAGDGFVATFT
MUL_4838|M.ulcerans_Agy99 VGSTQRAATVGDLRWRDLLDNHDNLVRHEIQRFGGREVNTAGDGFVATFS
Rv3617|M.tuberculosis_H37Rv WETT-------------ADLAGKTISVPSLFIAGTADPVLT---------
* :
Mflv_2257|M.gilvum_PYR-GCK -PEVARRVADLIPD-SVLVSLPTAGHSVLDIRERAAVEICKAVCSGELHE
Mvan_4434|M.vanbaalenii_PYR-1 -PEVARRIADLIPD-AALLELPTAGHSILDTREHAALRICEAVQAGQSHD
MMAR_4140|M.marinum_M -AMVAEHIASLLPN-AVLIELPTMAHSALDFREPAALAIAGAVCRGEFGA
MAV_1430|M.avium_104 -PAVAERVASLLPH-AVLLSLPDMAHSALDFHEAVALASADAVLRGDLAG
MSMEG_4998|M.smegmatis_MC2_155 -PALAQRVASLIPG-ATPVCMATAAHSIVDTRERAAIAIMQAVCNGAAEQ
MLBr_01899|M.leprae_Br4923 -PSSGRAVARAITG-ARLVLFDGMGHDLPQQLWDQAVGVLMSNFAKAS--
TH_1861|M.thermoresistible__bu -PTGGRAVARAIPG-ARLTLFDGMGHDLPEPLWDEIVAELDKNITAGR--
MAB_3880|M.abscessus_ATCC_1997 -PSGARAIARAIPG-SRLALIDGMGHDLPEPLWNHIITKLTENFARSEPA
Mb1935c|M.bovis_AF2122/97 SPSAAIACADDIVD-AVAALGIEVRIGIHAGEVEVRDASHGTDVAGVAVH
MUL_4838|M.ulcerans_Agy99 SPSAAINCADAVVD-AVAVLGIEVRVGIHAGEVEVR----GADVADLAVH
Rv3617|M.tuberculosis_H37Rv -FTRTDRAAEVISGPYREVLIDGAGHWLQQERPGEVTAALLEFLTGLELR
* :
Mflv_2257|M.gilvum_PYR-GCK LPSRAAELDALPANLTVRLLVGAIT-----VAARAESAVPGSAP----TA
Mvan_4434|M.vanbaalenii_PYR-1 LPSRSTELDALPANLTVRLLVRAIT-----VAARAESAVPGAIPRVVRQL
MMAR_4140|M.marinum_M LTGRGEELDAMPARLPIRALWKAIE-----LAAMAEHALPAAPLLHRRVS
MAV_1430|M.avium_104 LAARACTLNALPPRPEVRLLWALIA-----AAAMIEGALPIPAPLRRRLS
MSMEG_4998|M.smegmatis_MC2_155 LPHTADELDALPPRMPIRLLVAAIS-----AAVAAEGMADSVLPATS---
MLBr_01899|M.leprae_Br4923 --------------------------------------------------
TH_1861|M.thermoresistible__bu --------------------------------------------------
MAB_3880|M.abscessus_ATCC_1997 AETPESEAAGR---------------------------------------
Mb1935c|M.bovis_AF2122/97 IGARVCALAGPSEVLVSSTVRDIVAGSRHRFAERGEQELKGVPGRWRLCV
MUL_4838|M.ulcerans_Agy99 IGARVCALAGSSEVLVSSTVRDIVTGSSHRFAERGEHELKGVPGRWRLCA
Rv3617|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2257|M.gilvum_PYR-GCK PTS-------
Mvan_4434|M.vanbaalenii_PYR-1 ATS-------
MMAR_4140|M.marinum_M SA--------
MAV_1430|M.avium_104 CG--------
MSMEG_4998|M.smegmatis_MC2_155 ----------
MLBr_01899|M.leprae_Br4923 ----------
TH_1861|M.thermoresistible__bu ----------
MAB_3880|M.abscessus_ATCC_1997 ----------
Mb1935c|M.bovis_AF2122/97 LMRDDATRTR
MUL_4838|M.ulcerans_Agy99 LVREHLTGQR
Rv3617|M.tuberculosis_H37Rv ----------