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TMSDKRRRAHEKLAGMPGVRPVRRPVSPGNDSEFDLYYVRAGRKSAHPLVIIPGGPGVASMLVYKGLRRR AAAAGLDVIMIEHRGVGMSRHDDSGADLPPEAFTIDQVVDDIAAVLDDAHVDSAVIYGTSYGTYIAAGVG VRHPARVRSMILDSPLLSRDDIALARETIRRRLLDGDSPETAALAAKVRQLVDAGVMTARASQVAAAVYG YGGARLLERQLDLLLCGRMILWHVLFRFSAMYARKVPYRYEMDLVGRIAFRELDYAAEPDGLPLDPAQAI RETIAATDQFESEPYDLVAEMPRFGWPTVVVSGGHDLTTPAMVAEHIASLLPNAVLIELPTMAHSALDFR EPAALAIAGAVCRGEFGALTGRGEELDAMPARLPIRALWKAIELAAMAEHALPAAPLLHRRVSSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4140 | - | - | 100% (416) | hydrolase |
| M. marinum M | MMAR_2912 | - | 1e-07 | 32.98% (94) | hydrolase or acyltransferase |
| M. marinum M | MMAR_0981 | lipG1 | 5e-06 | 27.82% (133) | lipase/esterase LipG1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0665c | lipG | 1e-05 | 30.00% (130) | lipase/esterase LipG |
| M. gilvum PYR-GCK | Mflv_2257 | - | 1e-129 | 57.25% (407) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv0646c | lipG | 1e-05 | 30.00% (130) | lipase/esterase LipG |
| M. leprae Br4923 | MLBr_01899 | lipG | 3e-08 | 28.68% (136) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_4366c | - | 5e-05 | 28.21% (156) | putative hydrolase, alpha/beta fold |
| M. avium 104 | MAV_1430 | - | 1e-162 | 70.29% (414) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_4998 | - | 1e-135 | 60.64% (404) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_1861 | lipG | 2e-10 | 32.85% (137) | PROBABLE LIPASE/ESTERASE LIPG |
| M. ulcerans Agy99 | MUL_0733 | lipG1 | 3e-06 | 27.82% (133) | lipase/esterase LipG1 |
| M. vanbaalenii PYR-1 | Mvan_4434 | - | 1e-131 | 59.38% (421) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0665c|M.bovis_AF2122/97 ----------------MDIRSGTAVS-------------GDVKLYYEDMG
Rv0646c|M.tuberculosis_H37Rv ----------------MDIRSGTAVS-------------GDVKLYYEDMG
MLBr_01899|M.leprae_Br4923 ----------------MEVRSGYATS-------------GDLKLYYEDMG
MUL_0733|M.ulcerans_Agy99 ----------------MEIRTGYAQSGVGSGATSERQPAGDLKLYYEDMG
TH_1861|M.thermoresistible__bu ----------------MQIRTGFANVD---------GSPEPVDLYYEDLG
MMAR_4140|M.marinum_M ---MTMSDKRRRAHEKLAGMPGVRPVRRPVSPG----NDSEFDLYYVRAG
MAV_1430|M.avium_104 ---MTMNAKRRRMQQRLAKLPGVRAVRRPISPD----TADEFDLYYVRAG
MSMEG_4998|M.smegmatis_MC2_155 ------MANHGRKHATLAALPGVRAVRRPVAPG----ADEQFDVFYVRAG
Mflv_2257|M.gilvum_PYR-GCK MSVMTMNARRRRVHDRLAALPGVRPVRRPVHPG----ADGHFDVFYVRTG
Mvan_4434|M.vanbaalenii_PYR-1 MRVMTMNGRRRRAHDKLAALPGVRPVRRPVRPGVG-DADEKFDVYYVRTG
MAB_4366c|M.abscessus_ATCC_199 ----------------MTIHTHLQSIST---------TLGEIAVHDVPAA
: . . :. .
Mb0665c|M.bovis_AF2122/97 D-LDHPPVLLIMG-LGAQMLLWRTDFCARLVAKGLRVIRYDNRDVGLSTK
Rv0646c|M.tuberculosis_H37Rv D-LDHPPVLLIMG-LGAQMLLWRTDFCARLVAKGLRVIRYDNRDVGLSTK
MLBr_01899|M.leprae_Br4923 N-VDDPPVLLIMG-LGAQLVLWRTAFCEKLVAQGLRVVRYDNRDVGLSSR
MUL_0733|M.ulcerans_Agy99 D-INAPPVLLIMG-LGAQLLLWRTGFCQKPVDQGLRVIRYDNRDVGLSTK
TH_1861|M.thermoresistible__bu D-PADPPVLLIMG-LGAQLILWRDGFCRKLVERGLRVIRFDNRDVGLSSK
MMAR_4140|M.marinum_M R-KSAHPLVIIPGGPGVASMLVYKGLRRRAAAAGLDVIMIEHRGVGMSRH
MAV_1430|M.avium_104 R-KSRHPVVIIPGGPGVASVQMYKGLRRRAAAAGLDVIMIEHRGVGMSRH
MSMEG_4998|M.smegmatis_MC2_155 R-KSRHPVVLIPGGPGVASIQQYRGLRRRLATSGLDVIMVEHRGIGMSRR
Mflv_2257|M.gilvum_PYR-GCK R-KSAHPLVVIPGGPGAASIALYRSFRRHAAVAGLDVIMVEHRGVGLSRH
Mvan_4434|M.vanbaalenii_PYR-1 R-KSAHPLVIIPGGPGAASIALYRAFRRRAAVAGLDVIMVEHRGVGLSRH
MAB_4366c|M.abscessus_ATCC_199 GGADAPTLVMLHGGGPGASGLSNYEQNIPALSRTFRILLPDQPGFGGSYR
.:::: * : :: :: ..* * :
Mb0665c|M.bovis_AF2122/97 TE---RHRPGQPLATRLVRSWLGLPSQAAYTLEDMAADAAALLDHLDVKH
Rv0646c|M.tuberculosis_H37Rv TE---RHRPGQPLATRLVRSWLGLPSQAAYTLEDMAADAAALLDHLDVKH
MLBr_01899|M.leprae_Br4923 TDSTEQPCPSQPLTARLIRFWLGQRNACAYTLEDMTDDAVALLDHLSIER
MUL_0733|M.ulcerans_Agy99 ME---QPSARQPLMPQLIRSWLGRRSQTPYTLEDMADDAAALLDHLDIER
TH_1861|M.thermoresistible__bu LD---GRRERTPLPWRMLRSFAGLPSPAVYTLEDMADDAAGLLDHLQIDA
MMAR_4140|M.marinum_M DD------SGADLPP------------EAFTIDQVVDDIAAVLDDAHVDS
MAV_1430|M.avium_104 DD------AGADLPP------------EAMTVNQVVDDVAAVLDDARVDS
MSMEG_4998|M.smegmatis_MC2_155 TD------AGADLPA------------EAITVEQVLDDIAAVLDDAGVGT
Mflv_2257|M.gilvum_PYR-GCK DD------DGADLPP------------EALTVDAAVGDIAAVLDDAGVER
Mvan_4434|M.vanbaalenii_PYR-1 DD------SGADLPP------------EALTVDAAVDDIAAVLDDAQVER
MAB_4366c|M.abscessus_ATCC_199 PT-------GADLDE-------------RSITEITVDALFQVLDDLAVGS
* : :**. :
Mb0665c|M.bovis_AF2122/97 AHVVGASMGGMIAQIFAARFAQRTKTLAVIFSSNNHRFLPPPAPRALLAL
Rv0646c|M.tuberculosis_H37Rv AHVVGASMGGMIAQIFAARFAQRTKTLAVIFSSNNHRFLPPPAPRALLAL
MLBr_01899|M.leprae_Br4923 AHIVGASMGGMIAQIFAARFPTRTRSLAVFFSSNNRPFLPPPAPRALLAL
MUL_0733|M.ulcerans_Agy99 AHIVGASMGGMIAQIFAARFAERTNSLAVIFSSNNRPFLPPPAPRALLAV
TH_1861|M.thermoresistible__bu AHIVGASMGGMVAQVFAGRHAHRTRSLGVIFSSNNRPFLPPPGPRQLLSI
MMAR_4140|M.marinum_M AVIYGTSYGTYIAAGVGVRHPARVRSMILDSPLLSRDDIALARETIRRRL
MAV_1430|M.avium_104 AVVYGASYGTYIASGVGVRHPARVHGMVLDSPLLSRHDIVIVRRAIRRLL
MSMEG_4998|M.smegmatis_MC2_155 AVVYGTSYGSYLASGVGVRHPGRVAAMVLDSPVLSAHDLDEMRTAIRNLL
Mflv_2257|M.gilvum_PYR-GCK AVVYGASYGSYLAAGVGVRHPGRIHAMVLDSPLLSAHDIDAVRAQTRRVL
Mvan_4434|M.vanbaalenii_PYR-1 ASVYGTSYGSYLAAGVGVRHPGRVQSMVLDSPLLSADDIDAVRAQTRRVL
MAB_4366c|M.abscessus_ATCC_199 FHLLGNSLGGAAAIRMAQLRPERVTRLVLMAPGGGWLPFGPTPTEGQKEM
: * * * * .. . * : : . . : :
Mb0665c|M.bovis_AF2122/97 LTGPPP--------------------------------------DSPRDV
Rv0646c|M.tuberculosis_H37Rv LTGPPP--------------------------------------DSPRDV
MLBr_01899|M.leprae_Br4923 LTGPPT--------------------------------------GSRRDV
MUL_0733|M.ulcerans_Agy99 LNGPPP--------------------------------------GSPREV
TH_1861|M.thermoresistible__bu ITGPAP--------------------------------------DAPRDE
MMAR_4140|M.marinum_M LDGDSPETAALAAKVRQLVDAGVMTARASQVAAAVYGYGGARLLERQLDL
MAV_1430|M.avium_104 LRGDSPETASLAPKMRKLVDAGLMTATATQVVATIYGYGGARLLERQLDL
MSMEG_4998|M.smegmatis_MC2_155 WEGTGPDTAALAPKVRKLVETGRLTG--GQLAGLLYGYGGARLLDRQLDL
Mflv_2257|M.gilvum_PYR-GCK WED-----TDLAPRVRTLADEGALTPQDVLLMIGLYELAGPQVLRRQLDL
Mvan_4434|M.vanbaalenii_PYR-1 WDG-----ADLAPRMRRLAADGVLRSEDVLLAIGLYELAGPEGLGRQLDL
MAB_4366c|M.abscessus_ATCC_199 FRYFNG--------------------------------------EGPTEK
:
Mb0665c|M.bovis_AF2122/97 IVDN-------AVRVSKII--GSPAYPIPEDQVRAEAAESYDRNFHPWGI
Rv0646c|M.tuberculosis_H37Rv IVDN-------AVRVSKII--GSPAYPIPEDQVRAEAAESYDRNFHPWGI
MLBr_01899|M.leprae_Br4923 VVDN-------VVRVTKIT--GSPLYRMPEEQVRTNAAEIYDRSFYPLGV
MUL_0733|M.ulcerans_Agy99 IIDN-------VVRVTRIT--GSPGYQPTEEWIRADAAENYDRSYYPWGI
TH_1861|M.thermoresistible__bu VIEN-------AVKVGRLN--GSPAYPVPDEQLRADAATAFDRSYHPVGV
MMAR_4140|M.marinum_M LLCGRMILWHVLFRFSAMY-ARKVPYRYEMDLVGRIAFRELDYAAEPDGL
MAV_1430|M.avium_104 LLDGRKLLWWTLSRFTTL---RNLPFRYEEDLVSRIALRELDYAAEPDGL
MSMEG_4998|M.smegmatis_MC2_155 LLDGHTLLWRTLGRLGRVS-TRKAPYRNEIDLVGRIAFRELNYAGVPDGL
Mflv_2257|M.gilvum_PYR-GCK RVADRNRLWKIAERVTRLVTERKTPYHHEPDLVERIAYQELNYGAVPDGG
Mvan_4434|M.vanbaalenii_PYR-1 LLARRDWLWRVAESVTKLVTERKTAYRHEPDLVERIAYRELNYGAVPDGG
MAB_4366c|M.abscessus_ATCC_199 KMAA-------FIRAMVFD-----HKQFGRDVVSRRYQASLDEGHIEFYH
: . : : :
Mb0665c|M.bovis_AF2122/97 AQQFSAILGSGSLLR----------YDRRIVAP-----TVVIHGRADKLM
Rv0646c|M.tuberculosis_H37Rv AQQFSAILGSGSLLR----------YDRRIVAP-----TVVIHGRADKLM
MLBr_01899|M.leprae_Br4923 SRQFSAILGSGSLLH----------YNQRIIAP-----TVVIHGRADKLV
MUL_0733|M.ulcerans_Agy99 PRQFSAVLGSGSLLG----------YNRRTVAP-----TVVIHGRADKLM
TH_1861|M.thermoresistible__bu ARQFDAILGSGSLRR----------YNRRTTSP-----TVVIHGRADKLM
MMAR_4140|M.marinum_M PLDPAQAIRETIAAT---DQFESEPYDLVAEMPRFGWPTVVVSGGHDLTT
MAV_1430|M.avium_104 PLDPAVAEREVRTQT---ATFEDEPYDLPAEMPSFDWPTAVVSGGRDLIT
MSMEG_4998|M.smegmatis_MC2_155 PLDPALEMAEMARATKFHEPFEAEPYDLTAEMPKFTWPTVVVSGGRDLIT
Mflv_2257|M.gilvum_PYR-GCK PVDPAVALREMASGT---VEFVGEPYDLPAAMPGFGWPTAVLSGGRDLTT
Mvan_4434|M.vanbaalenii_PYR-1 PLDPSVALRQMATGD---VDFVAEPYDLTSEMPGFAWPTVVVSGGRDLTT
MAB_4366c|M.abscessus_ATCC_199 HYNAAFAKRNGMDPLWR---------DLHTITAP----TLLLWGRDDRTI
: . : . * :: * *
Mb0665c|M.bovis_AF2122/97 RPFGGRAVARAINGARLVLIDGMGH-------------------------
Rv0646c|M.tuberculosis_H37Rv RPFGGRAVARAINGARLVLIDGMGH-------------------------
MLBr_01899|M.leprae_Br4923 RPSSGRAVARAITGARLVLFDGMGH-------------------------
MUL_0733|M.ulcerans_Agy99 RPFGGRAVAKAINGARMVEFDGMGH-------------------------
TH_1861|M.thermoresistible__bu RPTGGRAVARAIPGARLTLFDGMGH-------------------------
MMAR_4140|M.marinum_M PAMVAEHIASLLPNAVLIELPTMAHSALDFREPAALAIAGAVCRGEFGAL
MAV_1430|M.avium_104 PPAVAERVASLLPHAVLLSLPDMAHSALDFHEAVALASADAVLRGDLAGL
MSMEG_4998|M.smegmatis_MC2_155 PPALAQRVASLIPGATPVCMATAAHSIVDTRERAAIAIMQAVCNGAAEQL
Mflv_2257|M.gilvum_PYR-GCK PPEVARRVADLIPDSVLVSLPTAGHSVLDIRERAAVEICKAVCSGELHEL
Mvan_4434|M.vanbaalenii_PYR-1 PPEVARRIADLIPDAALLELPTAGHSILDTREHAALRICEAVQAGQSHDL
MAB_4366c|M.abscessus_ATCC_199 TLEGAQMMLKHISDVQLHVFGRCGH-------------------------
.. : : : .*
Mb0665c|M.bovis_AF2122/97 --------DLPRQLWDRVIGELTRNFSEAG-----------------
Rv0646c|M.tuberculosis_H37Rv --------DLPRQLWDRVIGELTRNFSEAG-----------------
MLBr_01899|M.leprae_Br4923 --------DLPQQLWDQAVGVLMSNFAKAS-----------------
MUL_0733|M.ulcerans_Agy99 --------DLPRQLWDQVIGVLTSNFEQAE-----------------
TH_1861|M.thermoresistible__bu --------DLPEPLWDEIVAELDKNITAGR-----------------
MMAR_4140|M.marinum_M TGRGEELDAMPARLPIRALWKAIELAAMAEHALPAAPLLHRRVSSA-
MAV_1430|M.avium_104 AARACTLNALPPRPEVRLLWALIAAAAMIEGALPIPAPLRRRLSCG-
MSMEG_4998|M.smegmatis_MC2_155 PHTADELDALPPRMPIRLLVAAISAAVAAEGMADSVLPATS------
Mflv_2257|M.gilvum_PYR-GCK PSRAAELDALPANLTVRLLVGAITVAARAESAVPGSAP----TAPTS
Mvan_4434|M.vanbaalenii_PYR-1 PSRSTELDALPANLTVRLLVRAITVAARAESAVPGAIPRVVRQLATS
MAB_4366c|M.abscessus_ATCC_199 -----WVQLERQAEFDRLVADFLGEPA--------------------
. :