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M. tuberculosis H37Rv Rv1900c (lipJ)

annotation: PROBABLE LIGNIN PEROXIDASE LIPJ
coordinates: 2146245 - 2147633
length: 462

AQAPHIHRTRYAKCGDMDIAYQVLGDGPTDLLVLPGPFVPIDSIDDEPSLYRFHRRLASFSRVIRLDHRG
VGLSSRLAAITTLGPKFWAQDAIAVMDAVGCEQATIFAPSFHAMNGLVLAADYPERVRSLIVVNGSARPL
WAPDYPVGAQVRRADPFLTVALEPDAVERGFDVLSIVAPTVAGDDVFRAWWDLAGNRAGPPSIARAVSKV
IAEADVRDVLGHIEAPTLILHRVGSTYIPVGHGRYLAEHIAGSRLVELPGTDTLYWVGDTGPMLDEIEEF
ITGVRGGADAERMLATIMFTDIVGSTQHAAALGDDRWRDLLDNHDTIVCHEIQRFGGREVNTAGDGFVAT
FTSPSAAIACADDIVDAVAALGIEVRIGIHAGEVEVRDASHGTDVAGVAVHIGARVCALAGPSEVLVSST
VRDIVAGSRHRFAERGEQELKGVPGRWRLCVLMRDDATRTR*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv1900clipJ-100% (462)PROBABLE LIGNIN PEROXIDASE LIPJ
M. tuberculosis H37RvRv2212-2e-1125.09% (267) hypothetical protein Rv2212
M. tuberculosis H37RvRv1647-8e-1132.61% (138) hypothetical protein Rv1647

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1935clipJ0.099.57% (462) lignin peroxidase LIPJ
M. gilvum PYR-GCKMflv_2091-9e-1836.53% (167) putative adenylate/guanylate cyclase
M. leprae Br4923MLBr_01899lipG2e-1325.77% (291) putative hydrolase
M. abscessus ATCC 19977MAB_2330-5e-0932.81% (128) putative purine cyclase-like protein
M. marinum MMMAR_0286lipJ0.073.16% (462) lignin peroxidase LipJ
M. avium 104MAV_5228-0.072.03% (454) hydrolase, alpha/beta hydrolase fold family protein
M. smegmatis MC2 155MSMEG_4477-9e-7337.61% (468) hydrolase, alpha/beta hydrolase fold family protein
M. thermoresistible (build 8)TH_1244-1e-1835.80% (176) CONSERVED HYPOTHETICAL PROTEIN
M. ulcerans Agy99MUL_4838lipJ0.072.73% (462) lignin peroxidase LipJ
M. vanbaalenii PYR-1Mvan_4613-7e-1637.13% (167) putative adenylate/guanylate cyclase

CLUSTAL 2.0.9 multiple sequence alignment


Rv1900c|M.tuberculosis_H37Rv        MAQAPHIHRTRYAKCGDMDIAYQVLGDGPTDLLVLPGPFVPIDSIDDEPS
Mb1935c|M.bovis_AF2122/97           MAQAPHIHRTRYAKCGDMDIAYQVLGDGPTDLLVLPGPFVPIDSIDDEPS
MMAR_0286|M.marinum_M               MSQAPRTPRTRYARCGDLDIAYQVIGDHPIDLLVIPGASIPVDTIDSEPS
MUL_4838|M.ulcerans_Agy99           MSQAPRTPRTRYARCGDLDIAYQVIGDHPIDLLVIPGASIPVDTIDSEPS
MAV_5228|M.avium_104                MPGFSGTPRTRYASCGDTDIAYQVLGDGPIDLVLLPGPSIPIDSVDAEPS
MSMEG_4477|M.smegmatis_MC2_155      ------MAETSYASCGDLSLAYQLFGDGPIPLVFVGPFVGHVELFWTVPE
Mflv_2091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_4613|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_1244|M.thermoresistible__bu      --------------------------------------------------
MAB_2330|M.abscessus_ATCC_1997      --------------------------------------------MDVEPS
MLBr_01899|M.leprae_Br4923          -----MEVRSGYATSGDLKLYYEDMGNVDDPPVLLIMGLGAQLVLWRTAF
                                                                                      

Rv1900c|M.tuberculosis_H37Rv        LYRFHRRLASFSRVIRLDHRGVGLSSRLAAITTLGPKFWAQDAIAVMDAV
Mb1935c|M.bovis_AF2122/97           LYRFHRRLASFSRVIRLDHRGVGLSSRLAAITTLGPKFWAQDAIAVMDAV
MMAR_0286|M.marinum_M               MYRFHRRLASFSRLIRFDHRGVGLSSRVSSPDALGPRFWAEDAIAVMDAA
MUL_4838|M.ulcerans_Agy99           MYRFHRRLASFSRLIRFDHRGVGLSSRVSSPDALGPRFWAEDAIAVMDAA
MAV_5228|M.avium_104                MYRFHRRLAAFARVIRLDQRGIGLSSRVPSVDVIGPEFWARDVVSVMDAV
MSMEG_4477|M.smegmatis_MC2_155      FKSFFDQLASFCRVAIFDKAGTGLSDPVPKVRTLDDR--AAEIEAVMDAV
Mflv_2091|M.gilvum_PYR-GCK          ---------------------------------------MLILVCVLAVL
Mvan_4613|M.vanbaalenii_PYR-1       -----------------------------------------MALLVLAAV
TH_1244|M.thermoresistible__bu      ---------VAARPLPLAVAAAPGSPIPRRVGQDGAVTQIAIVVVALAGL
MAB_2330|M.abscessus_ATCC_1997      GLDAEPDGEFDSGIRKRRRGRTRGPVRHDSAQVTDGIDTTADEVPSTESA
MLBr_01899|M.leprae_Br4923          CEKLVAQG---LRVVRYDNRDVGLSSRTDSTEQPCPS-QPLTARLIRFWL
                                                                                      

Rv1900c|M.tuberculosis_H37Rv        GCEQATIFAPSFHAMNGLVLAADYPERVRSLIVVN-----GSARPLWAPD
Mb1935c|M.bovis_AF2122/97           GCEQATIFAPSFHAMNGLVLAADYPERVRSLIVVN-----GSARPLWAPD
MMAR_0286|M.marinum_M               GCQEATILASGFTATTALVLAADYPERVRSLVLIN-----ASARTLHAPD
MUL_4838|M.ulcerans_Agy99           GCQQATILASGFTATTALVLAADYPERVRSLVLIN-----ASARTLHAPD
MAV_5228|M.avium_104                GCERATVVAPSFTSMTGLVLAADYPDRVSSLVIIN-----GAARTVYAPD
MSMEG_4477|M.smegmatis_MC2_155      GFDDAVVLAMSEGGPASILFAANRPGRVRTLVAYGSFATMAGCRWEDLDG
Mflv_2091|M.gilvum_PYR-GCK          AAGLGIALAVQTR---RLTSARQEAEELRHRLDTR---------------
Mvan_4613|M.vanbaalenii_PYR-1       VVGLAVALAVQSR---RLRTARQEADELRRRLDTR---------------
TH_1244|M.thermoresistible__bu      ALAEAVALAVLWG---RLRRERRAADELRRRLDTR---------------
MAB_2330|M.abscessus_ATCC_1997      SRHFARASRTAGSWFRKMDRDPAVVAALRRARRSLP--------------
MLBr_01899|M.leprae_Br4923          GQRNACAYTLEDMTDDAVALLDHLSIERAHIVG-----------------
                                        .            :                                

Rv1900c|M.tuberculosis_H37Rv        YPVGAQVR-----------RADPFLTVALEPDAVERGFDVLSIVAPTVAG
Mb1935c|M.bovis_AF2122/97           YPVGAQVR-----------RADPFLTVALEPDAVEQGFDVLSIVAPTVAG
MMAR_0286|M.marinum_M               YELGIRSN-----------TAEPFLTLGTDPDAVEQGFDVLRIMAPSVAH
MUL_4838|M.ulcerans_Agy99           YELGIRSN-----------TAEPFLTLGTDPDAVEQGFDVLRIMAPSVAH
MAV_5228|M.avium_104                YPMGARIE-----------TLDPYTTVAVDPDAVDQGFDMLGLIAPSVAG
MSMEG_4477|M.smegmatis_MC2_155      DPVDIRARSVAEMGDEYAPTVEQVIHFQEQARAVRGQWGSGAAVRCAMPS
Mflv_2091|M.gilvum_PYR-GCK          -----------------------QLLVSGGTKAVKTVWQTANILR-----
Mvan_4613|M.vanbaalenii_PYR-1       -----------------------QMLVTGSTKAVKTVWQTANILR-----
TH_1244|M.thermoresistible__bu      -----------------------TTLMAGGREAVRTVWQTANILR-----
MAB_2330|M.abscessus_ATCC_1997      -----------------------GDPYFGDPLSTSGFGGASAVAR-----
MLBr_01899|M.leprae_Br4923          ---------------------------ASMGGMIAQIFAARFPTR-----
                                                                                      

Rv1900c|M.tuberculosis_H37Rv        DDVFRAWWDLAGNRAGPPSIARAVSKVIAEADVRDVLGHIEAPTLILHRV
Mb1935c|M.bovis_AF2122/97           DDVFRAWWDLAGNRAGPPSMARAVSKVIAEADVRDVLGHIEAPTLILHRV
MMAR_0286|M.marinum_M               DDAFRDWWDLAGNRAASPSTARAFINAVQASDARDSLPHITAPTLILHRV
MUL_4838|M.ulcerans_Agy99           DDAFRHWWDLAGNRAASPSTARAFINAVQASDARDSLPHITAPTLILHRV
MAV_5228|M.avium_104                DAAFRSWWDAAGNRAASPSMARAMILSIRHADVRDRLARITTPTLILHRT
MSMEG_4477|M.smegmatis_MC2_155      MGSMRQLG-MFERLCASPGMARATFEAAFRIDVRPILPTIAAPTLVIHAR
Mflv_2091|M.gilvum_PYR-GCK          ----------------KDGFGAAVRSSIEELADWAEVERPDLARLSLNGR
Mvan_4613|M.vanbaalenii_PYR-1       ----------------RDGFGAAVRSSIEELADWAEVERPDLARLAPNGR
TH_1244|M.thermoresistible__bu      ----------------TDGLGAAARSSIEDLADWAEVERPDLARLAANGK
MAB_2330|M.abscessus_ATCC_1997      ---------------AADRLVTDRDTAVREFGFGALQIWQAFTEKVSKQP
MLBr_01899|M.leprae_Br4923          ---------------------TRSLAVFFSSNNRPFLPPPAPRALL----
                                                                                      

Rv1900c|M.tuberculosis_H37Rv        GSTYIPVGHGRYLAEHIAGSRLVELPGTDTLYWVGDTGPMLDEIEEFITG
Mb1935c|M.bovis_AF2122/97           GSTYIPVGHGRYLAEHIAGSRLVELPGTDTLYWVGDTGPMLDEIEEFITG
MMAR_0286|M.marinum_M               GTKFVPVEHGRYLAEHIAGSRLVELPGSDSLYWVGDTAALLDEVEEFITG
MUL_4838|M.ulcerans_Agy99           GTKFVPVEHGRYLAEHIAGSRLVELPGSDSLYWVGDTAALLDEVEEFITG
MAV_5228|M.avium_104                DCVFTSVDHGRYLAEHIAGSRFVSLPGEDTLYWVGDTGPMLDEIEEFITG
MSMEG_4477|M.smegmatis_MC2_155      DDPAVPVQCSRYLADHISGARWLEVDGVDHAPWFTEADRVLTEIEEFVTG
Mflv_2091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_4613|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_1244|M.thermoresistible__bu      --------------------------------------------------
MAB_2330|M.abscessus_ATCC_1997      AN------------------------------------------------
MLBr_01899|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Rv1900c|M.tuberculosis_H37Rv        VRGG-ADAERMLATIMFTDIVGSTQHAAALGDDRWRDLLDNHDTIVCHEI
Mb1935c|M.bovis_AF2122/97           VRGG-ADAERMLATIMFTDIVGSTQHAAALGDDRWRDLLDNHDTIVCHEI
MMAR_0286|M.marinum_M               VRGG-FVTERVLTTVMFTDIVGSTQRAATVGDLRWRDLLDNHDNLVRHEI
MUL_4838|M.ulcerans_Agy99           VRGG-FVTERVLTAVMFTGIVGSTQRAATVGDLRWRDLLDNHDNLVRHEI
MAV_5228|M.avium_104                VRGG-SEAERLLTTIVFTDIVGSTERAAALGDYRWRDLLDNHDRIVRHEL
MSMEG_4477|M.smegmatis_MC2_155      NHAAPHNSHRALRTVLFTDIVASTQHAASNGDERWRAVLQRFGEVTEELS
Mflv_2091|M.gilvum_PYR-GCK          ------------LTIMFSDIEESTALNERIGDRAFVRLIGRHDKSVRKFV
Mvan_4613|M.vanbaalenii_PYR-1       ------------VAIMFSDIEESTALNERIGDRAFVRLLGRHDKPVRRHV
TH_1244|M.thermoresistible__bu      ------------VVILFSDIEGSTALNNRIGDRAWVRLIDRHSRLVRRFV
MAB_2330|M.abscessus_ATCC_1997      ----------REVTLVFTDLVGFSGWALEAGDEATLKLLRRVASVSEPPL
MLBr_01899|M.leprae_Br4923          --------------ALLTGPPTGSRRDVVVDN------VVRVTKITGSPL
                                                   :::.    :      .:      : .         

Rv1900c|M.tuberculosis_H37Rv        QRFGGREVNTAGDGFVATFTSPSAAIACADDIVDAVA---ALG--IEVRI
Mb1935c|M.bovis_AF2122/97           QRFGGREVNTAGDGFVATFTSPSAAIACADDIVDAVA---ALG--IEVRI
MMAR_0286|M.marinum_M               QRFGGREVNTAGDGFVATFSSPSAAINCADAVVDAVA---VLG--IEVRV
MUL_4838|M.ulcerans_Agy99           QRFGGREVNTAGDGFVATFSSPSAAINCADAVVDAVA---VLG--IEVRV
MAV_5228|M.avium_104                QRFGGREVNTAGDGFVATFSSPSAAISCADALVDAVA---ALG--IEVRV
MSMEG_4477|M.smegmatis_MC2_155      GRFGGVVVKSTGDGHLSTFEGPTHAIRYAEALRSDAE---TLG--IQIRA
Mflv_2091|M.gilvum_PYR-GCK          DKHEGHVVKSQGDGFMVAFAKPEQAVRCGLDIQHSLA---RRPNDIRVRM
Mvan_4613|M.vanbaalenii_PYR-1       DAHDGYVVKSQGDGFMVAFARPEQAVRCGLAIQHSLD---KRPNGIRVRI
TH_1244|M.thermoresistible__bu      KKHDGYVIKSQGDGFMVAFARPEQAVRCSVELQRALR---KRPDRIRVRI
MAB_2330|M.abscessus_ATCC_1997      LSAGGQVVKRMGDGIMAVFDDPVTALRAIIPARDALKNVEIQGYTPVMRI
MLBr_01899|M.leprae_Br4923          YRMPEEQVRTNAAEIYDRSFYPLGVSRQFSAILGSGS-------LLHYNQ
                                           :.  .         *  .                       . 

Rv1900c|M.tuberculosis_H37Rv        GIHAGEVEVRDASHGTDVAGVAVHIGARVCALAGPSEVLVSSTVRDIVAG
Mb1935c|M.bovis_AF2122/97           GIHAGEVEVRDASHGTDVAGVAVHIGARVCALAGPSEVLVSSTVRDIVAG
MMAR_0286|M.marinum_M               GIHAGEVEVR----GADVAGLAVHIGARVCALAGSSEVLVSSTVRDIVTG
MUL_4838|M.ulcerans_Agy99           GIHAGEVEVR----GADVADLAVHIGARVCALAGSSEVLVSSTVRDIVTG
MAV_5228|M.avium_104                GIHAGEVEVRG-ARKDDIAGMAVHIGARVAALAGPGEVLVSSTLRDIVTG
MSMEG_4477|M.smegmatis_MC2_155      AIHTGECELLG----DDIGGIAVHIAARILGQARAGEILVSRTVRDLVVG
Mflv_2091|M.gilvum_PYR-GCK          GVHTGKSVLRG----DDVFGRNVAMAARVAAAADGGEILVSSAVHRALAD
Mvan_4613|M.vanbaalenii_PYR-1       GIHVGKSVLRG----DDLFGRNVAMAARVAAEADGGEVLVSSAVRDALTD
TH_1244|M.thermoresistible__bu      GIHLGRSVRRG----DDLFGRNVALAARVAGAAEGGEVLVSQAVRDALNS
MAB_2330|M.abscessus_ATCC_1997      GIHAGTPQRIG----SDWLGVDVNIAARVMESAAKGGLAISQPALAKVPL
MLBr_01899|M.leprae_Br4923          RIIAPTVVIHG---RADKLVRPSSGRAVARAITGARLVLFDGMGHDLPQQ
                                     :              *         *     :    : ..         

Rv1900c|M.tuberculosis_H37Rv        SRHRFA---------ERGEQELKGVPGRWRLCVL----------------
Mb1935c|M.bovis_AF2122/97           SRHRFA---------ERGEQELKGVPGRWRLCVL----------------
MMAR_0286|M.marinum_M               SSHRFA---------ERGEHELKGVPGRWRLCAL----------------
MUL_4838|M.ulcerans_Agy99           SSHRFA---------ERGEHELKGVPGRWRLCAL----------------
MAV_5228|M.avium_104                SRHRFG---------DRGETALKGVPGQWRLYRL----------------
MSMEG_4477|M.smegmatis_MC2_155      SGTSFA---------DRGNVELRGVPGTWQLLAVGDGAGGGSPAGSVEAL
Mflv_2091|M.gilvum_PYR-GCK          CEDLA--------FDEQRDVELKGFSGSHTLYPVR---------------
Mvan_4613|M.vanbaalenii_PYR-1       ADDIV--------VDGERDAHLKGFSGSHTLYSVR---------------
TH_1244|M.thermoresistible__bu      AGDAGSDEVAGFDVDDGREVSLKGFPGRHRLFAVR---------------
MAB_2330|M.abscessus_ATCC_1997      AFLDHMGLTPTPVRRPLFSSRPAGVPENMKMYLLETR-------------
MLBr_01899|M.leprae_Br4923          LWDQAVG------------VLMSNFAKAS---------------------
                                                           ...                        

Rv1900c|M.tuberculosis_H37Rv        ----------------------------------MRDDATRTR------
Mb1935c|M.bovis_AF2122/97           ----------------------------------MRDDATRTR------
MMAR_0286|M.marinum_M               ----------------------------------VREHLTGQR------
MUL_4838|M.ulcerans_Agy99           ----------------------------------VREHLTGQR------
MAV_5228|M.avium_104                ----------------------------------LREHAAAER------
MSMEG_4477|M.smegmatis_MC2_155      LAAEPTPAARTATRRADRAVAAVAKRTPWALRGVARLTMSATRR-----
Mflv_2091|M.gilvum_PYR-GCK          -------------------------------------SASASR------
Mvan_4613|M.vanbaalenii_PYR-1       -------------------------------------SASASR------
TH_1244|M.thermoresistible__bu      -------------------------------------GQAGFRPRPRPE
MAB_2330|M.abscessus_ATCC_1997      ----------------------------------RQLPAPGDDGRV---
MLBr_01899|M.leprae_Br4923          -------------------------------------------------