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VAQAPHIHRTRYAKCGDMDIAYQVLGDGPTDLLVLPGPFVPIDSIDDEPSLYRFHRRLASFSRVIRLDHR GVGLSSRLAAITTLGPKFWAQDAIAVMDAVGCEQATIFAPSFHAMNGLVLAADYPERVRSLIVVNGSARP LWAPDYPVGAQVRRADPFLTVALEPDAVEQGFDVLSIVAPTVAGDDVFRAWWDLAGNRAGPPSMARAVSK VIAEADVRDVLGHIEAPTLILHRVGSTYIPVGHGRYLAEHIAGSRLVELPGTDTLYWVGDTGPMLDEIEE FITGVRGGADAERMLATIMFTDIVGSTQHAAALGDDRWRDLLDNHDTIVCHEIQRFGGREVNTAGDGFVA TFTSPSAAIACADDIVDAVAALGIEVRIGIHAGEVEVRDASHGTDVAGVAVHIGARVCALAGPSEVLVSS TVRDIVAGSRHRFAERGEQELKGVPGRWRLCVLMRDDATRTR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1935c | lipJ | - | 100% (462) | lignin peroxidase LIPJ |
| M. bovis AF2122 / 97 | Mb2235 | - | 2e-11 | 25.09% (267) | hypothetical protein Mb2235 |
| M. bovis AF2122 / 97 | Mb1674 | - | 8e-11 | 32.61% (138) | hypothetical protein Mb1674 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2091 | - | 9e-18 | 36.53% (167) | putative adenylate/guanylate cyclase |
| M. tuberculosis H37Rv | Rv1900c | lipJ | 0.0 | 99.57% (462) | lignin peroxidase LIPJ |
| M. leprae Br4923 | MLBr_01899 | lipG | 8e-13 | 25.43% (291) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_2330 | - | 5e-09 | 32.81% (128) | putative purine cyclase-like protein |
| M. marinum M | MMAR_0286 | lipJ | 0.0 | 73.38% (462) | lignin peroxidase LipJ |
| M. avium 104 | MAV_5228 | - | 0.0 | 72.47% (454) | hydrolase, alpha/beta hydrolase fold family protein |
| M. smegmatis MC2 155 | MSMEG_4477 | - | 2e-73 | 37.82% (468) | hydrolase, alpha/beta hydrolase fold family protein |
| M. thermoresistible (build 8) | TH_1244 | - | 1e-18 | 35.80% (176) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_4838 | lipJ | 0.0 | 72.94% (462) | lignin peroxidase LipJ |
| M. vanbaalenii PYR-1 | Mvan_4613 | - | 7e-16 | 37.13% (167) | putative adenylate/guanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1935c|M.bovis_AF2122/97 MAQAPHIHRTRYAKCGDMDIAYQVLGDGPTDLLVLPGPFVPIDSIDDEPS
Rv1900c|M.tuberculosis_H37Rv MAQAPHIHRTRYAKCGDMDIAYQVLGDGPTDLLVLPGPFVPIDSIDDEPS
MMAR_0286|M.marinum_M MSQAPRTPRTRYARCGDLDIAYQVIGDHPIDLLVIPGASIPVDTIDSEPS
MUL_4838|M.ulcerans_Agy99 MSQAPRTPRTRYARCGDLDIAYQVIGDHPIDLLVIPGASIPVDTIDSEPS
MAV_5228|M.avium_104 MPGFSGTPRTRYASCGDTDIAYQVLGDGPIDLVLLPGPSIPIDSVDAEPS
MSMEG_4477|M.smegmatis_MC2_155 ------MAETSYASCGDLSLAYQLFGDGPIPLVFVGPFVGHVELFWTVPE
Mflv_2091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4613|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1244|M.thermoresistible__bu --------------------------------------------------
MAB_2330|M.abscessus_ATCC_1997 --------------------------------------------MDVEPS
MLBr_01899|M.leprae_Br4923 -----MEVRSGYATSGDLKLYYEDMGNVDDPPVLLIMGLGAQLVLWRTAF
Mb1935c|M.bovis_AF2122/97 LYRFHRRLASFSRVIRLDHRGVGLSSRLAAITTLGPKFWAQDAIAVMDAV
Rv1900c|M.tuberculosis_H37Rv LYRFHRRLASFSRVIRLDHRGVGLSSRLAAITTLGPKFWAQDAIAVMDAV
MMAR_0286|M.marinum_M MYRFHRRLASFSRLIRFDHRGVGLSSRVSSPDALGPRFWAEDAIAVMDAA
MUL_4838|M.ulcerans_Agy99 MYRFHRRLASFSRLIRFDHRGVGLSSRVSSPDALGPRFWAEDAIAVMDAA
MAV_5228|M.avium_104 MYRFHRRLAAFARVIRLDQRGIGLSSRVPSVDVIGPEFWARDVVSVMDAV
MSMEG_4477|M.smegmatis_MC2_155 FKSFFDQLASFCRVAIFDKAGTGLSDPVPKVRTLDDR--AAEIEAVMDAV
Mflv_2091|M.gilvum_PYR-GCK ---------------------------------------MLILVCVLAVL
Mvan_4613|M.vanbaalenii_PYR-1 -----------------------------------------MALLVLAAV
TH_1244|M.thermoresistible__bu ---------VAARPLPLAVAAAPGSPIPRRVGQDGAVTQIAIVVVALAGL
MAB_2330|M.abscessus_ATCC_1997 GLDAEPDGEFDSGIRKRRRGRTRGPVRHDSAQVTDGIDTTADEVPSTESA
MLBr_01899|M.leprae_Br4923 CEKLVAQG---LRVVRYDNRDVGLSSRTDSTEQPCPS-QPLTARLIRFWL
Mb1935c|M.bovis_AF2122/97 GCEQATIFAPSFHAMNGLVLAADYPERVRSLIVVN-----GSARPLWAPD
Rv1900c|M.tuberculosis_H37Rv GCEQATIFAPSFHAMNGLVLAADYPERVRSLIVVN-----GSARPLWAPD
MMAR_0286|M.marinum_M GCQEATILASGFTATTALVLAADYPERVRSLVLIN-----ASARTLHAPD
MUL_4838|M.ulcerans_Agy99 GCQQATILASGFTATTALVLAADYPERVRSLVLIN-----ASARTLHAPD
MAV_5228|M.avium_104 GCERATVVAPSFTSMTGLVLAADYPDRVSSLVIIN-----GAARTVYAPD
MSMEG_4477|M.smegmatis_MC2_155 GFDDAVVLAMSEGGPASILFAANRPGRVRTLVAYGSFATMAGCRWEDLDG
Mflv_2091|M.gilvum_PYR-GCK AAGLGIALAVQTR---RLTSARQEAEELRHRLDTR---------------
Mvan_4613|M.vanbaalenii_PYR-1 VVGLAVALAVQSR---RLRTARQEADELRRRLDTR---------------
TH_1244|M.thermoresistible__bu ALAEAVALAVLWG---RLRRERRAADELRRRLDTR---------------
MAB_2330|M.abscessus_ATCC_1997 SRHFARASRTAGSWFRKMDRDPAVVAALRRARRSLP--------------
MLBr_01899|M.leprae_Br4923 GQRNACAYTLEDMTDDAVALLDHLSIERAHIVG-----------------
. :
Mb1935c|M.bovis_AF2122/97 YPVGAQVR-----------RADPFLTVALEPDAVEQGFDVLSIVAPTVAG
Rv1900c|M.tuberculosis_H37Rv YPVGAQVR-----------RADPFLTVALEPDAVERGFDVLSIVAPTVAG
MMAR_0286|M.marinum_M YELGIRSN-----------TAEPFLTLGTDPDAVEQGFDVLRIMAPSVAH
MUL_4838|M.ulcerans_Agy99 YELGIRSN-----------TAEPFLTLGTDPDAVEQGFDVLRIMAPSVAH
MAV_5228|M.avium_104 YPMGARIE-----------TLDPYTTVAVDPDAVDQGFDMLGLIAPSVAG
MSMEG_4477|M.smegmatis_MC2_155 DPVDIRARSVAEMGDEYAPTVEQVIHFQEQARAVRGQWGSGAAVRCAMPS
Mflv_2091|M.gilvum_PYR-GCK -----------------------QLLVSGGTKAVKTVWQTANILR-----
Mvan_4613|M.vanbaalenii_PYR-1 -----------------------QMLVTGSTKAVKTVWQTANILR-----
TH_1244|M.thermoresistible__bu -----------------------TTLMAGGREAVRTVWQTANILR-----
MAB_2330|M.abscessus_ATCC_1997 -----------------------GDPYFGDPLSTSGFGGASAVAR-----
MLBr_01899|M.leprae_Br4923 ---------------------------ASMGGMIAQIFAARFPTR-----
Mb1935c|M.bovis_AF2122/97 DDVFRAWWDLAGNRAGPPSMARAVSKVIAEADVRDVLGHIEAPTLILHRV
Rv1900c|M.tuberculosis_H37Rv DDVFRAWWDLAGNRAGPPSIARAVSKVIAEADVRDVLGHIEAPTLILHRV
MMAR_0286|M.marinum_M DDAFRDWWDLAGNRAASPSTARAFINAVQASDARDSLPHITAPTLILHRV
MUL_4838|M.ulcerans_Agy99 DDAFRHWWDLAGNRAASPSTARAFINAVQASDARDSLPHITAPTLILHRV
MAV_5228|M.avium_104 DAAFRSWWDAAGNRAASPSMARAMILSIRHADVRDRLARITTPTLILHRT
MSMEG_4477|M.smegmatis_MC2_155 MGSMRQLG-MFERLCASPGMARATFEAAFRIDVRPILPTIAAPTLVIHAR
Mflv_2091|M.gilvum_PYR-GCK ----------------KDGFGAAVRSSIEELADWAEVERPDLARLSLNGR
Mvan_4613|M.vanbaalenii_PYR-1 ----------------RDGFGAAVRSSIEELADWAEVERPDLARLAPNGR
TH_1244|M.thermoresistible__bu ----------------TDGLGAAARSSIEDLADWAEVERPDLARLAANGK
MAB_2330|M.abscessus_ATCC_1997 ---------------AADRLVTDRDTAVREFGFGALQIWQAFTEKVSKQP
MLBr_01899|M.leprae_Br4923 ---------------------TRSLAVFFSSNNRPFLPPPAPRALL----
Mb1935c|M.bovis_AF2122/97 GSTYIPVGHGRYLAEHIAGSRLVELPGTDTLYWVGDTGPMLDEIEEFITG
Rv1900c|M.tuberculosis_H37Rv GSTYIPVGHGRYLAEHIAGSRLVELPGTDTLYWVGDTGPMLDEIEEFITG
MMAR_0286|M.marinum_M GTKFVPVEHGRYLAEHIAGSRLVELPGSDSLYWVGDTAALLDEVEEFITG
MUL_4838|M.ulcerans_Agy99 GTKFVPVEHGRYLAEHIAGSRLVELPGSDSLYWVGDTAALLDEVEEFITG
MAV_5228|M.avium_104 DCVFTSVDHGRYLAEHIAGSRFVSLPGEDTLYWVGDTGPMLDEIEEFITG
MSMEG_4477|M.smegmatis_MC2_155 DDPAVPVQCSRYLADHISGARWLEVDGVDHAPWFTEADRVLTEIEEFVTG
Mflv_2091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4613|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1244|M.thermoresistible__bu --------------------------------------------------
MAB_2330|M.abscessus_ATCC_1997 AN------------------------------------------------
MLBr_01899|M.leprae_Br4923 --------------------------------------------------
Mb1935c|M.bovis_AF2122/97 VRGG-ADAERMLATIMFTDIVGSTQHAAALGDDRWRDLLDNHDTIVCHEI
Rv1900c|M.tuberculosis_H37Rv VRGG-ADAERMLATIMFTDIVGSTQHAAALGDDRWRDLLDNHDTIVCHEI
MMAR_0286|M.marinum_M VRGG-FVTERVLTTVMFTDIVGSTQRAATVGDLRWRDLLDNHDNLVRHEI
MUL_4838|M.ulcerans_Agy99 VRGG-FVTERVLTAVMFTGIVGSTQRAATVGDLRWRDLLDNHDNLVRHEI
MAV_5228|M.avium_104 VRGG-SEAERLLTTIVFTDIVGSTERAAALGDYRWRDLLDNHDRIVRHEL
MSMEG_4477|M.smegmatis_MC2_155 NHAAPHNSHRALRTVLFTDIVASTQHAASNGDERWRAVLQRFGEVTEELS
Mflv_2091|M.gilvum_PYR-GCK ------------LTIMFSDIEESTALNERIGDRAFVRLIGRHDKSVRKFV
Mvan_4613|M.vanbaalenii_PYR-1 ------------VAIMFSDIEESTALNERIGDRAFVRLLGRHDKPVRRHV
TH_1244|M.thermoresistible__bu ------------VVILFSDIEGSTALNNRIGDRAWVRLIDRHSRLVRRFV
MAB_2330|M.abscessus_ATCC_1997 ----------REVTLVFTDLVGFSGWALEAGDEATLKLLRRVASVSEPPL
MLBr_01899|M.leprae_Br4923 --------------ALLTGPPTGSRRDVVVDN------VVRVTKITGSPL
:::. : .: : .
Mb1935c|M.bovis_AF2122/97 QRFGGREVNTAGDGFVATFTSPSAAIACADDIVDAVA---ALG--IEVRI
Rv1900c|M.tuberculosis_H37Rv QRFGGREVNTAGDGFVATFTSPSAAIACADDIVDAVA---ALG--IEVRI
MMAR_0286|M.marinum_M QRFGGREVNTAGDGFVATFSSPSAAINCADAVVDAVA---VLG--IEVRV
MUL_4838|M.ulcerans_Agy99 QRFGGREVNTAGDGFVATFSSPSAAINCADAVVDAVA---VLG--IEVRV
MAV_5228|M.avium_104 QRFGGREVNTAGDGFVATFSSPSAAISCADALVDAVA---ALG--IEVRV
MSMEG_4477|M.smegmatis_MC2_155 GRFGGVVVKSTGDGHLSTFEGPTHAIRYAEALRSDAE---TLG--IQIRA
Mflv_2091|M.gilvum_PYR-GCK DKHEGHVVKSQGDGFMVAFAKPEQAVRCGLDIQHSLA---RRPNDIRVRM
Mvan_4613|M.vanbaalenii_PYR-1 DAHDGYVVKSQGDGFMVAFARPEQAVRCGLAIQHSLD---KRPNGIRVRI
TH_1244|M.thermoresistible__bu KKHDGYVIKSQGDGFMVAFARPEQAVRCSVELQRALR---KRPDRIRVRI
MAB_2330|M.abscessus_ATCC_1997 LSAGGQVVKRMGDGIMAVFDDPVTALRAIIPARDALKNVEIQGYTPVMRI
MLBr_01899|M.leprae_Br4923 YRMPEEQVRTNAAEIYDRSFYPLGVSRQFSAILGSGS-------LLHYNQ
:. . * . .
Mb1935c|M.bovis_AF2122/97 GIHAGEVEVRDASHGTDVAGVAVHIGARVCALAGPSEVLVSSTVRDIVAG
Rv1900c|M.tuberculosis_H37Rv GIHAGEVEVRDASHGTDVAGVAVHIGARVCALAGPSEVLVSSTVRDIVAG
MMAR_0286|M.marinum_M GIHAGEVEVR----GADVAGLAVHIGARVCALAGSSEVLVSSTVRDIVTG
MUL_4838|M.ulcerans_Agy99 GIHAGEVEVR----GADVADLAVHIGARVCALAGSSEVLVSSTVRDIVTG
MAV_5228|M.avium_104 GIHAGEVEVRG-ARKDDIAGMAVHIGARVAALAGPGEVLVSSTLRDIVTG
MSMEG_4477|M.smegmatis_MC2_155 AIHTGECELLG----DDIGGIAVHIAARILGQARAGEILVSRTVRDLVVG
Mflv_2091|M.gilvum_PYR-GCK GVHTGKSVLRG----DDVFGRNVAMAARVAAAADGGEILVSSAVHRALAD
Mvan_4613|M.vanbaalenii_PYR-1 GIHVGKSVLRG----DDLFGRNVAMAARVAAEADGGEVLVSSAVRDALTD
TH_1244|M.thermoresistible__bu GIHLGRSVRRG----DDLFGRNVALAARVAGAAEGGEVLVSQAVRDALNS
MAB_2330|M.abscessus_ATCC_1997 GIHAGTPQRIG----SDWLGVDVNIAARVMESAAKGGLAISQPALAKVPL
MLBr_01899|M.leprae_Br4923 RIIAPTVVIHG---RADKLVRPSSGRAVARAITGARLVLFDGMGHDLPQQ
: * * : : ..
Mb1935c|M.bovis_AF2122/97 SRHRFA---------ERGEQELKGVPGRWRLCVL----------------
Rv1900c|M.tuberculosis_H37Rv SRHRFA---------ERGEQELKGVPGRWRLCVL----------------
MMAR_0286|M.marinum_M SSHRFA---------ERGEHELKGVPGRWRLCAL----------------
MUL_4838|M.ulcerans_Agy99 SSHRFA---------ERGEHELKGVPGRWRLCAL----------------
MAV_5228|M.avium_104 SRHRFG---------DRGETALKGVPGQWRLYRL----------------
MSMEG_4477|M.smegmatis_MC2_155 SGTSFA---------DRGNVELRGVPGTWQLLAVGDGAGGGSPAGSVEAL
Mflv_2091|M.gilvum_PYR-GCK CEDLA--------FDEQRDVELKGFSGSHTLYPVR---------------
Mvan_4613|M.vanbaalenii_PYR-1 ADDIV--------VDGERDAHLKGFSGSHTLYSVR---------------
TH_1244|M.thermoresistible__bu AGDAGSDEVAGFDVDDGREVSLKGFPGRHRLFAVR---------------
MAB_2330|M.abscessus_ATCC_1997 AFLDHMGLTPTPVRRPLFSSRPAGVPENMKMYLLETR-------------
MLBr_01899|M.leprae_Br4923 LWDQAVG------------VLMSNFAKAS---------------------
...
Mb1935c|M.bovis_AF2122/97 ----------------------------------MRDDATRTR------
Rv1900c|M.tuberculosis_H37Rv ----------------------------------MRDDATRTR------
MMAR_0286|M.marinum_M ----------------------------------VREHLTGQR------
MUL_4838|M.ulcerans_Agy99 ----------------------------------VREHLTGQR------
MAV_5228|M.avium_104 ----------------------------------LREHAAAER------
MSMEG_4477|M.smegmatis_MC2_155 LAAEPTPAARTATRRADRAVAAVAKRTPWALRGVARLTMSATRR-----
Mflv_2091|M.gilvum_PYR-GCK -------------------------------------SASASR------
Mvan_4613|M.vanbaalenii_PYR-1 -------------------------------------SASASR------
TH_1244|M.thermoresistible__bu -------------------------------------GQAGFRPRPRPE
MAB_2330|M.abscessus_ATCC_1997 ----------------------------------RQLPAPGDDGRV---
MLBr_01899|M.leprae_Br4923 -------------------------------------------------