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M. thermoresistible (build 8) TH_1880 (-)

annotation: flavin-type hydroxylase
coordinates: 3678895 - 3680325
length: 477

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_1880--100% (477)flavin-type hydroxylase
M. thermoresistible (build 8)TH_4641-4e-5034.00% (497) PUTATIVE oxygenase
M. thermoresistible (build 8)TH_0968-8e-4032.29% (511) 3-(3-hydroxy-phenyl)propionate hydroxylase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1780-4e-1326.28% (312) hypothetical protein Mb1780
M. gilvum PYR-GCKMflv_5009-3e-5034.99% (503) monooxygenase, FAD-binding
M. tuberculosis H37RvRv1751-2e-1225.96% (312) hypothetical protein Rv1751
M. leprae Br4923MLBr_02276-2e-0524.68% (312) putative FAD-linked oxidoreductase
M. abscessus ATCC 19977MAB_0857-1e-10946.14% (492) hypothetical protein MAB_0857
M. marinum MMMAR_4271-1e-10345.33% (492) hypothetical protein MMAR_4271
M. avium 104MAV_2736-1e-10646.86% (493) hypothetical protein MAV_2736
M. smegmatis MC2 155MSMEG_2252-0.070.50% (478) flavin-type hydroxylase
M. ulcerans Agy99MUL_0979-1e-1229.38% (354) oxidoreductase
M. vanbaalenii PYR-1Mvan_2422-1e-10044.49% (490) hypothetical protein Mvan_2422

CLUSTAL 2.0.9 multiple sequence alignment


Mb1780|M.bovis_AF2122/97            --------------------------------------MIATMPSMARRS
Rv1751|M.tuberculosis_H37Rv         --------------------------------------MIATMPSMARRS
TH_1880|M.thermoresistible__bu      ------------------------------------VYDVIVVGGGPTGM
MSMEG_2252|M.smegmatis_MC2_155      MADAESLAAHGSRVAG----------------KGISVKDVVIVGGGPTGA
MAV_2736|M.avium_104                MRGVRFSE--RSVRG----------------------HAVLVAGAGPTGL
Mvan_2422|M.vanbaalenii_PYR-1       MTTTRHKDTHKDTREDTREDTRDDSRDDGGDPNGDTDHAVVVGGGGPTGM
MMAR_4271|M.marinum_M               MAD----------------------------------HAVVVVGAGPTGL
MAB_0857|M.abscessus_ATCC_1997      MAE----------------------------------HAVVVAGAGPTGL
Mflv_5009|M.gilvum_PYR-GCK          MPGAHR-------------------------------SDVVVVGAGPTGL
MUL_0979|M.ulcerans_Agy99           --------------------------------MTTYDTDVLVVGGGPGGL
MLBr_02276|M.leprae_Br4923          -------------------------------MRVETSADVVVVGAGPAGS
                                                                           :    . .   

Mb1780|M.bovis_AF2122/97            RHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMGETTTCAIIG---
Rv1751|M.tuberculosis_H37Rv         RHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMGETTTCAIIG---
TH_1880|M.thermoresistible__bu      MLAGELRLHGVRVLVVEKNSEPPAH-VRSLGLHVRSIEMLDQRGLLDRF-
MSMEG_2252|M.smegmatis_MC2_155      MLAGELRLYEVDVMVLDKDIEPTKV-VRSLGLHARSIEIMDQRGLLDRF-
MAV_2736|M.avium_104                MLAGELGLAGVDVALVERRADQQLIGSRAGGLHARTLEILDQRGIVDRF-
Mvan_2422|M.vanbaalenii_PYR-1       MTAAELALAGVDVAVVERRTTPEITGSRAGGLLSRTLEILDQRGVVDRF-
MMAR_4271|M.marinum_M               MLAGELALAGVDVAVVERRVSQDLVGSRAGGLHSRTIEVLDQRGIADRF-
MAB_0857|M.abscessus_ATCC_1997      MLAGELALAGIDVALLERRGSHEEVGSRAAGLHSRTIEVFDQRGIAERF-
Mflv_5009|M.gilvum_PYR-GCK          TLACCLRLHGVSVRVLDAAAG-PATTSRANFLHARGSEVLDRMGALGTL-
MUL_0979|M.ulcerans_Agy99           ATALNARKRGLSVIVADPRESPIDKACGEGLMPGGLAELKS---------
MLBr_02276|M.leprae_Br4923          AAATWAARAGNDVIVIDSVCFPRDKACGDG-LTPRAVAELKRLGLDDWLN
                                                    :                                 

Mb1780|M.bovis_AF2122/97            --GGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTTMRLLDEL
Rv1751|M.tuberculosis_H37Rv         --GGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTTMRLLDEL
TH_1880|M.thermoresistible__bu      LAHGQRHPVGGFFAAIAK-PPAELD----TAHGYVLGIRQPVTDRLLAEW
MSMEG_2252|M.smegmatis_MC2_155      LEVGRRHPVGGYFAGITKAPPRTLD----TAHPYVLGIPQPVTDRILVEH
MAV_2736|M.avium_104                LAEGQVAQVAG-FAQIRL-DISDFP----TRHPYGLALWQNHIERILADW
Mvan_2422|M.vanbaalenii_PYR-1       LSAGETMQVHG-FAQVRL-DVSDLP----TRHPYGLALWQKHIERILAEW
MMAR_4271|M.marinum_M               LAQGTATQVAR-FAAIPL-DISDFP----TRHNYGLALWQNRIERILAEW
MAB_0857|M.abscessus_ATCC_1997      LAQGRTGQVTH-FSGIFM-SIEDFP----TRHPYALGLLQHYTEKTLAAW
Mflv_5009|M.gilvum_PYR-GCK          PQESLRALRITNYLGDRPLATLEFGDPGMRTAAPPMVVSQAKVEAALRAR
MUL_0979|M.ulcerans_Agy99           LDVDPAGVPFQGIAYVSQQRRAEAR----FRTGPGRGVRRTTVHATLAAR
MLBr_02276|M.leprae_Br4923          TRIRHRGLRMSGFGGEVEVDWPGPS-----FPSTSSAVPRLELDDRIRKV
                                                                           :      :   

Mb1780|M.bovis_AF2122/97            GLWERFAALPYSEVRTATLHSN--GRAVTYIDFERLHQPYPYVAMVPQWD
Rv1751|M.tuberculosis_H37Rv         GLWERFAALPYSEVRTATLHSN--GRAVTYIDFERLHQPYPYVAMVPQWD
TH_1880|M.thermoresistible__bu      AAERGAVIRRGCAVVGLDQDAA--GITVELADGSVQRARYLVGCDGGRST
MSMEG_2252|M.smegmatis_MC2_155      AVASGAVLRRGCEAVGLAQDDD--GVSVTLADGTQVRARYVVGCDGGRST
MAV_2736|M.avium_104                VGELGVPIYRGHRIATCTQDDT--GVDVVASDGRTLRGQYLVGCDGGRSV
Mvan_2422|M.vanbaalenii_PYR-1       VDELAVPVYRGREVVGVRQDGA--GVDIELSDGRVLRAGYLVGCDGGRSL
MMAR_4271|M.marinum_M               VAELRVRIYRGCEVTDITQDDN--GVDLTLSDGPPLRADYVVGCDGGRSL
MAB_0857|M.abscessus_ATCC_1997      IDELGVPIYYNAEAVGLGQDDV--GVDVALADGSTLRGQYLVGCDGGRST
Mflv_5009|M.gilvum_PYR-GCK          LADLDVEPEWGRKVIDVREDAD--GVVADLADGARVRGQWLVGCDGTTSV
MUL_0979|M.ulcerans_Agy99           AKEQDAEWIR-TRVTDVVQDAH--GVTAAG-----VRAKWLVAADGLHSA
MLBr_02276|M.leprae_Br4923          AENSGARMLLGTKAVSVYHDSSRRAASVTLADGTEVGCRQLIIADGARSP
                                                       .    .                  .      

Mb1780|M.bovis_AF2122/97            LLNLLAEAAQAEPSFTLRMKTEVTGLLREGGKVTGVRYQGAEGPGELRAE
Rv1751|M.tuberculosis_H37Rv         LLNLLAEAAQAEPSFTLRMKTEVTGLLREGGKVTGVRYQGAEGPGELRAE
TH_1880|M.thermoresistible__bu      VRKLAGIGFPGEPARSETLLGEMSLSADPATVAAVVAEVRKTQLRFGAMP
MSMEG_2252|M.smegmatis_MC2_155      VRKLMGVGFPGEPSRVDTLIGEMQVGVTPEQVTAVVAEVRKMQLRFGAGP
MAV_2736|M.avium_104                IRKAAGIDFPGWEATTSYLLAEAEMDWRTGQPPQWG-IHHDSLGVHALSE
Mvan_2422|M.vanbaalenii_PYR-1       IRKSAGIEFPGWEPTTSYLLAEVEIAPEDGREPEWG-IRRDALGVHALSR
MMAR_4271|M.marinum_M               VRRAVGIDFPGWDPTTSSLIAEVEVAVGSESGPNLGEVRHDALGVHGFTR
MAB_0857|M.abscessus_ATCC_1997      IRKAAGIGFPGHDPSCSAMLVDAEIT---EQPLEFGLLRKPGQAFLGILP
Mflv_5009|M.gilvum_PYR-GCK          VRRQTGIEFPGVRLSERFLLADIHLDWAVDRAGTTGWIHPDGVVGAMPMP
MUL_0979|M.ulcerans_Agy99           VRRAVGITATAGTPRRYGVRRHYRVP----AWSEFVEVHWSPWGEAYVTP
MLBr_02276|M.leprae_Br4923          LGRKLGRSWHQKTVYGVAARGYLTTPRSDDLWLTSHLELRSPDGAVLPGY
                                    : .  .                                            

Mb1780|M.bovis_AF2122/97            LTVACDGRWSIARHEAGLKARE--FPVNFDVWWFKLPREGDAEF------
Rv1751|M.tuberculosis_H37Rv         LTVACDGRWSIARHEAGLKARE--FPVNFDVWWFKLPREGDAEF------
TH_1880|M.thermoresistible__bu      LG---DGVYRVIVPAEGVAGDR--AEPTLDEFRRRLKAFAGTDFGA--HT
MSMEG_2252|M.smegmatis_MC2_155      LG---DGLYRVMVPAAEVVEDRS-ATPTLDEFRQQLRATAGTDLGV--HS
MAV_2736|M.avium_104                TEP--AGGVRVLVTERQLRSAA---EPNLDDLRQALIAVYRTDYGI--HS
Mvan_2422|M.vanbaalenii_PYR-1       SD---DGPVRIMVTEQDLRRSG---VPDLAELREALVTVYGTDFGI--HS
MMAR_4271|M.marinum_M               LPD--GGPLRVVVTERQLDAGG---EPSLGDLSAALTAVYGTDYGI--HS
MAB_0857|M.abscessus_ATCC_1997      FE---EGWCRLAFSTGLDRLGV---EPTLEEAKEALIAIAGTDFGI--HN
Mflv_5009|M.gilvum_PYR-GCK          STDGRDDLWRLFVYDPSLDRKPT-DSEILDRISELVPYRTGRRVKI--GD
MUL_0979|M.ulcerans_Agy99           VEP---DLVGVAILSRQR--------PEIDWFPWLAQQLRGASPG-----
MLBr_02276|M.leprae_Br4923          GWIFPLGNGEVNIGVGALSTSKRPADLALRSLISYYTDLRRHEWGFSGQP
                                          .   :                 :                     

Mb1780|M.bovis_AF2122/97            -SFLPRFSPGKGLGVIPREGYFQIA------YLGPKGTDAQLRERGIEEF
Rv1751|M.tuberculosis_H37Rv         -SFLPRFSPGKGLGVIPREGYFQIA------YLGPKGTDAQLRERGIEEF
TH_1880|M.thermoresistible__bu      PRWLSRFGDATRLAERYRAGRVFLAGDAAHVHPPAGGQGLNLGIQDAFNL
MSMEG_2252|M.smegmatis_MC2_155      PRWLSRFGDGTRLADRYRTGRVLLAGDAAHVHPPVGGQGLNLGVQDAFNL
MAV_2736|M.avium_104                PRWISRFTDAARQAARYRDRRVLLAGDAAHIHHPVGGQGLNTGVQDAVNL
Mvan_2422|M.vanbaalenii_PYR-1       PTSISRFTDTARQAVAYRSGRILLVGDAAHVHHPVGGQGLNTGMQDAVNL
MMAR_4271|M.marinum_M               PTWISRFTDLTRQAATYRQGRVLIAGDAAHVHDPVGGQGLNTGVQDAVNL
MAB_0857|M.abscessus_ATCC_1997      PRWISRFSDMTRQADRYRDGRVFLAGDSAHIHFPFGGQGLNTGIQDAVNL
Mflv_5009|M.gilvum_PYR-GCK          AEWLSMFTVHRRLADTYRRGRVLIAGDAAHVHAPFGGQGMLTGIGDAENV
MUL_0979|M.ulcerans_Agy99           --AARGCGPLRQVVSRRVAGRVLLVGDAAGYEDALTGEGITLAVKQAAAA
MLBr_02276|M.leprae_Br4923          RAVSSALLPMGGAVSGVAGPNWMLIGDAAACVNPLNGEGIDYGLETGRLA
                                                           :            * .           

Mb1780|M.bovis_AF2122/97            RRDVSELLPEATASVAALASTDEVKHLNVKVNRLRRWHIDGLLCIGDAAH
Rv1751|M.tuberculosis_H37Rv         RRDVSELLPEATASVAALASMDEVKHLNVKVNRLRRWHIDGLLCIGDAAH
TH_1880|M.thermoresistible__bu      GWKLAAAVGGWAPDGLLDTYHAERHPVAADVLNNTRAQMELMSP-EPGPR
MSMEG_2252|M.smegmatis_MC2_155      GWKLAASINGWAPDGLLDSYEAERRPVAAAVLDNTRAQMELLSP-EPGPQ
MAV_2736|M.avium_104                GWKLALVVGGASPPALLDTYHAERHPVGERVLRNAIAQMALLRP-DERTR
Mvan_2422|M.vanbaalenii_PYR-1       GWKLAQVVQGWSPDTLLDTYHDERQPVGARVLRNAVAQMALLRP-DDRTT
MMAR_4271|M.marinum_M               GWKLAQVVNRRSPESLLDTYHAERHPVAARVLRTTMAQVALRRL-DYRKK
MAB_0857|M.abscessus_ATCC_1997      GWKLAAVIKGHAPDALLDTYHLERHPVAERVLHNTMAQTPLSEA-GPRID
Mflv_5009|M.gilvum_PYR-GCK          GFKLALVVRGLAADDLLDTYEAERRPLATQVLRGTSAITRVNVAGNPIVR
MUL_0979|M.ulcerans_Agy99           VRAIADNDP--------ASYEAAWHRVTRSYRWLTRGLVLASAP-RPARR
MLBr_02276|M.leprae_Br4923          AELLDLRDLSYVWPSLLQQHYGRGFSVAR--------RLALLLTFKRCLP
                                       :                      :                       

Mb1780|M.bovis_AF2122/97            AMSPVAG-VGINLAVQDAVAAATILAEPLREHR----VSSRHLAAVRRRR
Rv1751|M.tuberculosis_H37Rv         AMSPVAG-VGINLAVQDAVAAATILAEPLREHR----VSSRHLAAVRRRR
TH_1880|M.thermoresistible__bu      AVRWLLA-ELMDFEEVNRYLTEKITAIGVRYHT----MGDGHGLLGRRMR
MSMEG_2252|M.smegmatis_MC2_155      AVRRLLA-QLMAFEEVNRYLTEMITATGIRYD-----FGAEDDLVGRRLR
MAV_2736|M.avium_104                ALRDLVT-ELLGMDEPRKRFAAMISGLDVRYD-----LGPGHPLLGRRMP
Mvan_2422|M.vanbaalenii_PYR-1       VLHGVVS-DMLDMDEPRRRFAAMMSGLDIHYD-----LGDGHPLLGLRMP
MMAR_4271|M.marinum_M               ALSDTIS-ELLMMDEPRKRFAAMMSGLDIRYH-----LGGGHPLLGRRMP
MAB_0857|M.abscessus_ATCC_1997      ALRDIVA-DLLAMDEPRKRIAGMMSGLDIHYM-----LGDGHQLLGRRMP
Mflv_5009|M.gilvum_PYR-GCK          FLRDRVAPRVFGLPAVQRWTTYTASQLWVSYRNGPLGGRGSKPRPGDRID
MUL_0979|M.ulcerans_Agy99           AIVPACALLPPVFPVWGKYPGKLTAQSGGHQAD--AAHPGHRLIPAPPKP
MLBr_02276|M.leprae_Br4923          AIGPSAMRSTSLITIAVRVMANLVTDDDADWVARVWRSGGWASWLVDRRP
                                     :          :                                     

Mb1780|M.bovis_AF2122/97            AFPTAVTQAVQRVLHRRLLG-PLLQGRDPTPPAALLGLVERLPWLSAVP-
Rv1751|M.tuberculosis_H37Rv         AFPTAVTQAVQRVLHRRLLG-PLLQGRDPTPPAALLGLVERLPWLSAVP-
TH_1880|M.thermoresistible__bu      DIPLTGG----RLYARMHAGRGVLLDRTG--TLSVSGWADRVDHIVD---
MSMEG_2252|M.smegmatis_MC2_155      DIRLRRG----RLYELTRTGRGLLLDQTG--QLSAAGWSDRVDHVVD---
MAV_2736|M.avium_104                DLDLVTADGASRVFALLRNARPVLLNFAGAGRRSVAGWADRVRVVDAKCV
Mvan_2422|M.vanbaalenii_PYR-1       DLDLETAHGPTRVSALLRQARPVLLDLGAPDAVDLTGWEARVRMVRANAA
MMAR_4271|M.marinum_M               DLDLTTADGPRRVFTHLHAARPVLLNLAEPGRFDIAGWRHRVLLIDAKYV
MAB_0857|M.abscessus_ATCC_1997      DLDVVTADGAVRVYEHLHTARPVLFNFGARQILNVEGWEDRVHVVDAKYS
Mflv_5009|M.gilvum_PYR-GCK          DAPCSRPDGTATRLHGELGGRWALLLPRGVPAVGAAAVRGPAGYLADH--
MUL_0979|M.ulcerans_Agy99           SLPARIQIGPIPSAAHCQPSAPGVPLLPSAPAAPLPNWPYPP--------
MLBr_02276|M.leprae_Br4923          PFS-----------------------------------------------
                                                                                      

Mb1780|M.bovis_AF2122/97            -----------AYFVGVGVRPEHAPAFARRGPGNRKGP------------
Rv1751|M.tuberculosis_H37Rv         -----------AYFVGVGVRPEHAPAFARRGPGNRKGP------------
TH_1880|M.thermoresistible__bu      -------PGAALDVPAVLLRPDGHVAWVGADHPGQQDLTARLSRWFGAPA
MSMEG_2252|M.smegmatis_MC2_155      -------VSDELDVPAVLLRPDGHIAWVGDE---QGDLEGCLVRWFGVPA
MAV_2736|M.avium_104                ADWELPVLGRVSAPPAVLIRPDGHVAWAGDP--NDPGLHDALTTWCGPPA
Mvan_2422|M.vanbaalenii_PYR-1       TVWELPVIGEVPAPAAVLIRPDGHVAWVAGD--SAAAPAEAAARWFGAPT
MMAR_4271|M.marinum_M               GVWELPVLGAIAAPAAALIRPDGYVAWVGDDL-TDRGLFDALTAWFGRPA
MAB_0857|M.abscessus_ATCC_1997      GIWELPVLGEVSAPDAVLVRPDGYVAWVGEG--SADGLRGALTRWVGSPS
Mflv_5009|M.gilvum_PYR-GCK          -----VVTLHHDRDDVMLVRPDAHLAWRGAHD-DPTGLDRWLATALHPGG
MUL_0979|M.ulcerans_Agy99           ----------APPEAAPPPAPPGPPG------------------------
MLBr_02276|M.leprae_Br4923          --------------------------------------------------
                                                                                      

Mb1780|M.bovis_AF2122/97            -----------
Rv1751|M.tuberculosis_H37Rv         -----------
TH_1880|M.thermoresistible__bu      -----------
MSMEG_2252|M.smegmatis_MC2_155      -----------
MAV_2736|M.avium_104                AGG--------
Mvan_2422|M.vanbaalenii_PYR-1       GRR--------
MMAR_4271|M.marinum_M               VPSPRLRASAP
MAB_0857|M.abscessus_ATCC_1997      RA---------
Mflv_5009|M.gilvum_PYR-GCK          TQ---------
MUL_0979|M.ulcerans_Agy99           -----------
MLBr_02276|M.leprae_Br4923          -----------