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VKVVIVGAGMGGMSAAIALRQIGIDTVVYERVTENKPVGAAISVWSNGVKCLNYLGLQEETAELGGKVET MSYVDGHTGDTMCRFSMHPLIEQVGQRPYPIARAELQLMLMKAYGIDDINFGMKMVGVENDTAGSAAKAT FADGTTVSADVIIGADGAGSITREYVLGGPVSRRYAGYVNYNGLVSTDDAIGPATEWTTYVGDGKRVSVM PVSDDRFYFFFDVVEPQGSPYEEGRVREVLRAHFAGWTPGVQTLIDTLDPLATNRVEILDLDPFHTWVKG RVAVLGDAAHNTTPDIGQGGCSAMEDAIALQWAFKDHPDDVHAALAAYQSARTERAADLVLRARKRCDVT HAKDPQVTSRWYDELRNEDGTNIIRGIVGNIVGGPLTPVTAATEG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5278 | - | - | 100% (395) | monooxygenase, FAD-binding |
| M. vanbaalenii PYR-1 | Mvan_3960 | - | 4e-40 | 30.86% (337) | monooxygenase, FAD-binding |
| M. vanbaalenii PYR-1 | Mvan_4906 | mhpA | 9e-17 | 26.18% (359) | 3-(3-hydroxyphenyl)propionate hydroxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0590c | - | 3e-12 | 24.63% (337) | hypothetical protein Mb0590c |
| M. gilvum PYR-GCK | Mflv_2621 | - | 2e-38 | 29.57% (345) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv0575c | - | 3e-12 | 24.63% (337) | hypothetical protein Rv0575c |
| M. leprae Br4923 | MLBr_02276 | - | 2e-06 | 26.52% (230) | putative FAD-linked oxidoreductase |
| M. abscessus ATCC 19977 | MAB_1601c | - | 9e-36 | 29.53% (359) | putative monooxygenase |
| M. marinum M | MMAR_4944 | - | 0.0 | 81.03% (390) | oxidoreductase |
| M. avium 104 | MAV_4429 | - | 1e-29 | 29.10% (354) | FAD binding domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4641 | - | 4e-39 | 31.09% (341) | salicylate hydroxylase |
| M. thermoresistible (build 8) | TH_4641 | - | 1e-07 | 22.77% (347) | PUTATIVE oxygenase |
| M. ulcerans Agy99 | MUL_0460 | - | 2e-95 | 79.17% (216) | hypothetical protein MUL_0460 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5278|M.vanbaalenii_PYR-1 -------MKVVIVGAGMGGMSAAIALRQIGIDTVVYERVTENKPVGAAIS
MMAR_4944|M.marinum_M -------MKAVIIGAGIGGMSAAIALRQIGIDTEVYERVTENKPVGAAIS
MUL_0460|M.ulcerans_Agy99 -------MKAVIIGAGIGGMSAAIALRQIGIDTEVYERVTENKPVGAAIS
Mb0590c|M.bovis_AF2122/97 -------MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYMID
Rv0575c|M.tuberculosis_H37Rv -------MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYMID
Mflv_2621|M.gilvum_PYR-GCK -----MSARISVIGAGISGLAAAVALERAGHHVSVIEQRTD-TGAGSGIS
MSMEG_4641|M.smegmatis_MC2_155 -----MAASFLVVGAGITGLATAAALQRRGHDVCVAEARAD-TASGAGIS
MAB_1601c|M.abscessus_ATCC_199 -----MSDHIVVVGAGIAGLATAVAIQQSGRDVVVVDDRDG-TSAGYAIT
MAV_4429|M.avium_104 MVGDARPLRVLVVGAGVAGISVARGLLRDGHDVTVFERRPRLAAAGGAVT
TH_4641|M.thermoresistible__bu -MARETTTDVVVVGAGPVGLAVACGLLAHGLDVRVIDKAPAPATTSRANF
MLBr_02276|M.leprae_Br4923 -MRVETSADVVVVGAGPAGSAAATWAARAGNDVIVIDSVCFPRDKACGDG
: *** * : * * * : .
Mvan_5278|M.vanbaalenii_PYR-1 VWSNGVKCLNYLGLQEETAELGGKVETMSYVDGHTGDTMCRFSMHPLIEQ
MMAR_4944|M.marinum_M VWSNGVKCLNYLGLEQQTARLGGIVETMSYAEAHSGETMCRISMQPLIEQ
MUL_0460|M.ulcerans_Agy99 VWSNGVKCLNYLGLDQQTARLGGIVETMSYAEAHSGETMCRISMQPLIEQ
Mb0590c|M.bovis_AF2122/97 FWGVGYQVAKRMGITDQIAAAGYHMEHVRSVG-PTGKVKADLGVDVFRRM
Rv0575c|M.tuberculosis_H37Rv FWGVGYQVAKRMGITDQIAAAGYHMEHVRSVG-PTGKVKADLGVDVFRRM
Mflv_2621|M.gilvum_PYR-GCK LWPNALAALDQIGLGDSVRDAGGRVTAG-AIRWRDGTWVRRPSVRRIVDA
MSMEG_4641|M.smegmatis_MC2_155 IWPNALAALDAIGLGDPVRAAGGRVTAG-ALRWHDGTWLRHPAAERITRA
MAB_1601c|M.abscessus_ATCC_199 LWPNALAACDALGIGEDVRAASARVEAG-TMRWYDGRILREPPSGKFTEA
MAV_4429|M.avium_104 VWSNGETVLRQLGVEMDG--AGRQLSSVGAVT-STGRPLATLDVTAMARR
TH_4641|M.thermoresistible__bu LHARGSEVLDRLGALGGLP--ERSVRAMQITTHLGGEPVMRMQFGDPGMR
MLBr_02276|M.leprae_Br4923 LTPRAVAELKRLGLDDWLN------TRIRHRGLRMSGFGGEVEVDWPGPS
. . :* .
Mvan_5278|M.vanbaalenii_PYR-1 VGQRPYPIARAELQLMLMKAYG--IDDINFGMKMVGVENDTAGSAAKATF
MMAR_4944|M.marinum_M VGQRPYPIARAELQQMLMEAYG--IDEIHFGMKMVEVANRDG--AATATF
MUL_0460|M.ulcerans_Agy99 VGQRPYPIARAELQQMLMEAYG--IDDIHFGMKMVEVANQDG--AATATF
Mb0590c|M.bovis_AF2122/97 VGDDFTSLPRGDLAAAIYTTIED-QVETIFDDSIATIDEHRD--GVRLTF
Rv0575c|M.tuberculosis_H37Rv VGDDFTSLPRGDLAAAIYTTIED-QVETIFDDSIATIDEHRD--GVRLTF
Mflv_2621|M.gilvum_PYR-GCK LGEPLVVVRRSRLTDILREALP--AGTVRTGLAATRVSVGAS--SVRITL
MSMEG_4641|M.smegmatis_MC2_155 LGEPLVVIRRRVLTEILSGALA--PGTVVHGLEAHTVETCAS--GIRVTF
MAB_1601c|M.abscessus_ATCC_199 VGEPVAVTDRNQLLAILANRLT--PGTVRYGARVSNVRDGLH--GTSVEL
MAV_4429|M.avium_104 LGAPVRMVPRRVLLERLLDGFP--TGRIHCDRRAVALATSRD--GVSVEF
TH_4641|M.thermoresistible__bu TAAPPMVISQAEVEAALRNRLAELGGRVELDCPLTGLRQDAS--TVTAGI
MLBr_02276|M.leprae_Br4923 FPSTSSAVPRLELDDRIRKVAENSGARMLLGTKAVSVYHDSSRRAASVTL
: : : . : :
Mvan_5278|M.vanbaalenii_PYR-1 ADGTTVSADVIIGADGAGSITREYVLGGPVSRRYAGYVNYNGLVSTDDAI
MMAR_4944|M.marinum_M ADGTIASADILIGADGANSITREYVLGGPVTRRYAGYVNYNGLVEVDEAI
MUL_0460|M.ulcerans_Agy99 TDGTIASADILIGADGANSITREYVLGGPVTRRYAGYVNYNGLVEVDEAI
Mb0590c|M.bovis_AF2122/97 ERTAPRDFDLVIGADGLHSNVRRLVFG--PERDFEHYLGCKVAACVVDGY
Rv0575c|M.tuberculosis_H37Rv ERTAPRDFDLVIGADGLHSNVRRLVFG--PERDFEHYLGCKVAACVVDGY
Mflv_2621|M.gilvum_PYR-GCK SDGEVRESDAVVGADGVNSVLARTLNG-PLRTRYVGYTAWRGIAAHPLDP
MSMEG_4641|M.smegmatis_MC2_155 SDGSVREASAVVGADGVDSVVARHLNG-PLRRRYAGYTAWRGIAAHPLDP
MAB_1601c|M.abscessus_ATCC_199 ADGQSLTAAAVIGADGIGSLVAQYLNG-PLAFRYSGYTAWRGIADISIPD
MAV_4429|M.avium_104 TDGTVAEGDVLIGADGLHSMVREWVGA--RHAKATGWCSWQGLVSLPEIA
TH_4641|M.thermoresistible__bu GGGGELRGRWLVGCDGTGSSTRKSVGIGYPGARLSERFLLADVYLDWRLD
MLBr_02276|M.leprae_Br4923 ADGTEVGCRQLIIADGARSPLGRKLGRSWHQKTVYGVAARGYLTTPRSDD
:: .** * . :
Mvan_5278|M.vanbaalenii_PYR-1 GPAT--EWTTYVGDGKRVSVMPVSDDR-FYFFFDVVEPQGSPYEEGR--V
MMAR_4944|M.marinum_M SPAN--EWTMYVGDGKRVSAMPVADDR-FYFFFDVVEPEGLPFEKGT--A
MUL_0460|M.ulcerans_Agy99 SPAN--EWTMYVGDGKRVSAMPPTTPRPASGRADARRWKTRWHCNGR--S
Mb0590c|M.bovis_AF2122/97 RPRDERSYVLYNTVDRQLARFALRGDRTMFLFVFRAEHDNPGVAP-----
Rv0575c|M.tuberculosis_H37Rv RPRDERSYVLYNTVDRQLARFALRGDRTMFLFVFRAEHDNPGVAP-----
Mflv_2621|M.gilvum_PYR-GCK ELGG-----ETLGPGTQVGHVPLGPDHTYWFATERTAEGGS--APGG--E
MSMEG_4641|M.smegmatis_MC2_155 ELSG-----ETMGAGVEVGHVPLGADHTYWFATERASQGQR--SPDG--E
MAB_1601c|M.abscessus_ATCC_199 ELAG-----LTVGPGIEFGHLPLSLGRTYWFAGERSLEAQR--APDG--E
MAV_4429|M.avium_104 ESDA---ALMMIGGSGNLGLWPAGGAEVQWWFDLP--WSTGFVRPQH--P
TH_4641|M.thermoresistible__bu RSGT----TGWIHPDGMVGAMPMPDGLWRIIAYDP---GPGDLDQGA--L
MLBr_02276|M.leprae_Br4923 LWLT-----SHLELRSPDGAVLPGYGWIFPLGNGEVNIGVGALSTSKRPA
.
Mvan_5278|M.vanbaalenii_PYR-1 REVLRAHFAGWTPGVQTLIDTLDPLATNRVEILDL-DPFHTWVKGRVAVL
MMAR_4944|M.marinum_M REVLREQFAGWAPGVQALIDKLDPTTTNRVEILDL-DPFHTWVKGRVAVL
MUL_0460|M.ulcerans_Agy99 RTTPPTLRPRWPP--------IRPAAPNGPAIWYC-GPVS----------
Mb0590c|M.bovis_AF2122/97 KDELRDQFGDVGWESRDILAALDDVEDLYFDVVSQ-IRMDRWSRGRVLLI
Rv0575c|M.tuberculosis_H37Rv KDELRDQFGDVGWESRDILAALDDVEDLYFDVVSQ-IRMDRWSRGRVLLI
Mflv_2621|M.gilvum_PYR-GCK HAYLTAKVADWADPIPRLVATTDPGDLLRNDLYDR-ARAARWSDGRAVLI
MSMEG_4641|M.smegmatis_MC2_155 LTHLRRLFGSWAEPIPQLLAATDPADVLRNDLYDR-EPARCWARGPVVLA
MAB_1601c|M.abscessus_ATCC_199 IEYLARKFGNWADPIPRLLRQSRESSVLRGDVYDR-GRLRRVAGGRVVLV
MAV_4429|M.avium_104 IETIRSHFAGWSEPVDRVLAILTDEDLAASPFPHFRHPIPPPGRGRVTLL
TH_4641|M.thermoresistible__bu ERLLYERTGHRVKVTGTVWQSEFRVHRRLADTYRR---------GRVFIA
MLBr_02276|M.leprae_Br4923 DLALRSLISYYTDLRRHEWGFSGQPRAVSSALLPMGGAVSGVAGPNWMLI
Mvan_5278|M.vanbaalenii_PYR-1 GDAAHNTTPDIGQGGCSAMEDAIALQWAFKDHPD-------DVHAALAAY
MMAR_4944|M.marinum_M GDAAHNTTPDIGQGGCSAMEDAVALQWALKDNPT-------DVAAALAAY
MUL_0460|M.ulcerans_Agy99 --AATSSTP-----------------------------------------
Mb0590c|M.bovis_AF2122/97 GDAAGCISLLGGEGTGLAITEAYVLAGELARAGG-------DHRRAFDAY
Rv0575c|M.tuberculosis_H37Rv GDAAGCISLLGGEGTGLAITEAYVLAGELARAGG-------DHRRAFDAY
Mflv_2621|M.gilvum_PYR-GCK GDAAHPMRPHLGQGGCQGIEDAAILARFLELAD--------DVPTAFERF
MSMEG_4641|M.smegmatis_MC2_155 GDAAHPMRPHLGQGGCQGLEDAATLAALVAREP--------DLPTAFARF
MAB_1601c|M.abscessus_ATCC_199 GDAAHPMRPHLGQGGCQSLEDAAVLSVAISERS--------SLPSAFREY
MAV_4429|M.avium_104 GDAAHTMPPTLAQGTNQALLDTMVLCQALADFGRGTPGGQADVANALRWY
TH_4641|M.thermoresistible__bu GDAAHAHAPFGGQGMLTGLGDAENLAFKLALVIRG-----YAGPALLDTY
MLBr_02276|M.leprae_Br4923 GDAAACVNPLNGEGIDYGLETGRLAAELLDLRDLS-----YVWPSLLQQH
**
Mvan_5278|M.vanbaalenii_PYR-1 QSARTERAADL--------VLRARKRCDVTHAKDPQVTSRWYDELRNEDG
MMAR_4944|M.marinum_M QASRTERAGDL--------VLRARKRCDVIHAKDPDTTAAWYEELRNEDG
MUL_0460|M.ulcerans_Agy99 ---RTPIPPQP--------GMRS---CETNTAP-----------------
Mb0590c|M.bovis_AF2122/97 EKRLRPFIEGK--------QASAAKFIWFFRHPN----PIRPVVSQRCDA
Rv0575c|M.tuberculosis_H37Rv EKRLRPFIEGK--------QASAAKFIWFFATRTRFGLWFRNVAMRTMNF
Mflv_2621|M.gilvum_PYR-GCK EAFRKPRVGML--------VREAQTLGRIVNVRPAVLSGLAGRATALIPE
MSMEG_4641|M.smegmatis_MC2_155 ATLRRRRVTRM--------VRTSRMIGRIVNLRPAVLSAAASRATVLVPE
MAB_1601c|M.abscessus_ATCC_199 ARRRRSRTRAV--------VSRSRHIGNVTFARPAVVGGLLTRASARIPA
MAV_4429|M.avium_104 EKTRRRRVRAVSW----VASLPVSHGEAVLRPAALVSDRLQAAALTMFLR
TH_4641|M.thermoresistible__bu EAERRPLATEVLRNTSAATKLNIADRGVGRFLRDRVVLPLLALPSVQRRL
MLBr_02276|M.leprae_Br4923 YGRGFSVARRLALLLTFKRCLPAIGPSAMRSTSLITIAVRVMANLVTDDD
Mvan_5278|M.vanbaalenii_PYR-1 TNIIRGIVGNIVGGPLTPVTAATEG-------------------------
MMAR_4944|M.marinum_M TNIIRGLVANIMGGPLTPLS------------------------------
MUL_0460|M.ulcerans_Agy99 TSFAGSSPTSWVGRSLR---------------------------------
Mb0590c|M.bovis_AF2122/97 HDELRPAGDAVRRQRA----------------------------------
Rv0575c|M.tuberculosis_H37Rv GPLATLFAGSVRDDFELPDYTW----------------------------
Mflv_2621|M.gilvum_PYR-GCK RMVTAHLAWIAAGSAFVLPTAADLAR------------------------
MSMEG_4641|M.smegmatis_MC2_155 AVLTRQLASIAARSAFTPVD------------------------------
MAB_1601c|M.abscessus_ATCC_199 SVFWRQLSSIAGYEAGNLAVRP----------------------------
MAV_4429|M.avium_104 WTSHRRMSDHINRSVGEAINRSLGEAPKIPSRR-----------------
TH_4641|M.thermoresistible__bu TYQTSQLWVTYRGGPLAPRTVSMTTPRPGDRVPDQRCVRDDGHISRLYEQ
MLBr_02276|M.leprae_Br4923 ADWVARVWRSGGWASWLVDRRPPFS-------------------------
Mvan_5278|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4944|M.marinum_M --------------------------------------------------
MUL_0460|M.ulcerans_Agy99 --------------------------------------------------
Mb0590c|M.bovis_AF2122/97 --------------------------------------------------
Rv0575c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4641|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1601c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4429|M.avium_104 --------------------------------------------------
TH_4641|M.thermoresistible__bu LGGRWAVLEPGSGRHHREGPGLLGTAHTFLGEYVVGLRGAEMRGCDAFLV
MLBr_02276|M.leprae_Br4923 --------------------------------------------------
Mvan_5278|M.vanbaalenii_PYR-1 ------------------------------
MMAR_4944|M.marinum_M ------------------------------
MUL_0460|M.ulcerans_Agy99 ------------------------------
Mb0590c|M.bovis_AF2122/97 ------------------------------
Rv0575c|M.tuberculosis_H37Rv ------------------------------
Mflv_2621|M.gilvum_PYR-GCK ------------------------------
MSMEG_4641|M.smegmatis_MC2_155 ------------------------------
MAB_1601c|M.abscessus_ATCC_199 ------------------------------
MAV_4429|M.avium_104 ------------------------------
TH_4641|M.thermoresistible__bu RPDGHLAWRGRDATDLADWLKSALTVGRVR
MLBr_02276|M.leprae_Br4923 ------------------------------