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RKQLGRPSGSCHHDQMNAKTTCAVVGGGPAGMVLGLLLARAGVEVTVLEKHADFLRDFRGDTVHPTTLRL IDELGLWPKFSALPHSRLERATVDVGAGRTITVVDFGRLRQPHPYIAMVPQWDLLNLLAEAGEAEPTFTL RMCTEATGLIREGGRVVGVRYQDPDGPGELRADLTVGCDGRGSVLRGLAGLQVREFPVSFDAWWFRLPRP ADDSIYTLVPRIAPGKAMIVIPREGYLQIAMLIPKGTDAERRARGLDAFRADVLALLPEAATTIETITSL DDVKHLDVRLNRLRRWHTDGLLFIGDAAHAMSPAGGVGINVAIQDAVATARLLADPLRRGAVTERDLAAV RRRRVVPAALTQALQRQIDKRFLRPILDGDVTGPPPALVRAIERAPWLTFVPAYLVGVGVRPERAPEFAK RRPT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0442 | - | - | 100% (425) | hypothetical protein Mvan_0442 |
| M. vanbaalenii PYR-1 | Mvan_2422 | - | 2e-14 | 27.99% (343) | hypothetical protein Mvan_2422 |
| M. vanbaalenii PYR-1 | Mvan_4906 | mhpA | 1e-13 | 25.93% (324) | 3-(3-hydroxyphenyl)propionate hydroxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1780 | - | 1e-158 | 65.93% (408) | hypothetical protein Mb1780 |
| M. gilvum PYR-GCK | Mflv_0304 | - | 0.0 | 75.85% (410) | hypothetical protein Mflv_0304 |
| M. tuberculosis H37Rv | Rv1751 | - | 1e-159 | 65.93% (408) | hypothetical protein Rv1751 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4756c | - | 1e-133 | 60.93% (407) | hypothetical protein MAB_4756c |
| M. marinum M | MMAR_2627 | - | 1e-162 | 67.00% (406) | oxidoreductase |
| M. avium 104 | MAV_4364 | - | 1e-81 | 46.58% (395) | hypothetical protein MAV_4364 |
| M. smegmatis MC2 155 | MSMEG_4962 | - | 1e-147 | 64.88% (410) | hypothetical protein MSMEG_4962 |
| M. thermoresistible (build 8) | TH_1880 | - | 1e-16 | 28.34% (307) | flavin-type hydroxylase |
| M. ulcerans Agy99 | MUL_3663 | - | 1e-103 | 50.24% (412) | hypothetical protein MUL_3663 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0442|M.vanbaalenii_PYR-1 --------------------------------MRKQLGRPSGSCHHDQMN
Mflv_0304|M.gilvum_PYR-GCK --------------------------------MR----------DDDTVS
Mb1780|M.bovis_AF2122/97 MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
Rv1751|M.tuberculosis_H37Rv MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
MMAR_2627|M.marinum_M ------------------------------------------------MG
MSMEG_4962|M.smegmatis_MC2_155 ------------------------------------------------MT
MAB_4756c|M.abscessus_ATCC_199 ------------------------------------------------MS
MAV_4364|M.avium_104 --------------------------------------------------
MUL_3663|M.ulcerans_Agy99 ---------------------------------------------MPQPS
TH_1880|M.thermoresistible__bu --------------------------------------------------
Mvan_0442|M.vanbaalenii_PYR-1 AKTTCAVVGGGPAGMVLGLLLARAGVEVTVLEKHADFLRDFRGDTVHPTT
Mflv_0304|M.gilvum_PYR-GCK DTTTCAIVGGGPAGMVLGLLLARAGVEVTVLEKHADFLRDFRGDTVHPTT
Mb1780|M.bovis_AF2122/97 ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTT
Rv1751|M.tuberculosis_H37Rv ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTT
MMAR_2627|M.marinum_M EKTTCAIIGGGPAGMVLGLLLARAGVEVTLLEKHGDFLRDFRGDTVHPTT
MSMEG_4962|M.smegmatis_MC2_155 EKTTCAVVGGGPAGMVLGLLLARAGIEVTVFEKHADFLRDFRGDTVHPAT
MAB_4756c|M.abscessus_ATCC_199 EKTTCVVVGGGPAGIFAGLLLARAGVEVVVLEKHGDFLRDFRGDTVHPST
MAV_4364|M.avium_104 --------------MVHALLLARAGIPVVVLEKHNDFLRDFRGDTVHPTT
MUL_3663|M.ulcerans_Agy99 ETTSVLVAGGGPAGMVLGLLLARAGVDVTVMEKHADFLRDSRGDTVHAST
TH_1880|M.thermoresistible__bu -VYDVIVVGGGPTGMMLAGELRLHGVRVLVVEKNSEPPAHVRSLGLHVRS
:. . * *: * :.**: : . *. :* :
Mvan_0442|M.vanbaalenii_PYR-1 LRLIDELGLWPKFSALPHSRLERATVDVGAGRTITVVDFGRLRQP---HP
Mflv_0304|M.gilvum_PYR-GCK LRLLDDLGLWPRFADISHSRLDHATVDVGAGRSVTMVDFRRLRQP---HP
Mb1780|M.bovis_AF2122/97 MRLLDELGLWERFAALPYSEVRTATLHS-NGRAVTYIDFERLHQP---YP
Rv1751|M.tuberculosis_H37Rv MRLLDELGLWERFAALPYSEVRTATLHS-NGRAVTYIDFERLHQP---YP
MMAR_2627|M.marinum_M MRLLDELGLWERFAELPFSEVRKATLDT-NGRSVTYIDFGRLNQP---HP
MSMEG_4962|M.smegmatis_MC2_155 LRLLDELGLFEKFDALPHSRVERARFDL-GGREVTVVDFGRLNLP---HR
MAB_4756c|M.abscessus_ATCC_199 LRLLDELGLFDRFDKLPHTKLQRMRVTRPDGEQIVMADLTRLRTP---HP
MAV_4364|M.avium_104 LRIMDELGLIDEFLRLPHTKIDTVAFDT-DGSIRTFGNFKVLKRLGFNQP
MUL_3663|M.ulcerans_Agy99 LRLLDELGLGSQFAQIPHRLIDTISMKV--QGQPVDLDLKHLPGA---HQ
TH_1880|M.thermoresistible__bu IEMLDQRGLLDRFLAHGQRHPVGGFFAAIAKPPAELDTAHGYVLGIRQPV
:.::*: ** .* .
Mvan_0442|M.vanbaalenii_PYR-1 YIAMVPQWDLLN--------LLAEAGEAEPTFTLRMCTEATGLIR-----
Mflv_0304|M.gilvum_PYR-GCK YIAMVPQWDLLN--------LLADAGRAEPTFTLRMSTEVTGVLR-----
Mb1780|M.bovis_AF2122/97 YVAMVPQWDLLN--------LLAEAAQAEPSFTLRMKTEVTGLLR-----
Rv1751|M.tuberculosis_H37Rv YVAMVPQWDLLN--------LLAEAAQAEPSFTLRMKTEVTGLLR-----
MMAR_2627|M.marinum_M YVAMVPQWDLLN--------LLAEAAQAEPSFTLRMNTEVTGLLQ-----
MSMEG_4962|M.smegmatis_MC2_155 YIALVPQWDFLD--------LLADAAKEEPTFTLRMQTEVTGLLK-----
MAB_4756c|M.abscessus_ATCC_199 YIAMVPQWDLLD--------MLAEVGSEEPDFNLRMRHEVTGLIWD----
MAV_4364|M.avium_104 YIAMMPQWDFLD--------FIAEKASAYPEFTLIRNAEVTDLIL-----
MUL_3663|M.ulcerans_Agy99 HIALVPQWDFLE--------LLAAAAEAEPTFRLLRSTEVTGVLWGDG--
TH_1880|M.thermoresistible__bu TDRLLAEWAAERGAVIRRGCAVVGLDQDAAGITVELADGSVQRARYLVGC
::.:* :. . : : .
Mvan_0442|M.vanbaalenii_PYR-1 -----EGGRVVGVRYQDPDG-PGELRADLTVGCD----------------
Mflv_0304|M.gilvum_PYR-GCK -----EGSRVTGVRYETADG-TGELQAGLTVACD----------------
Mb1780|M.bovis_AF2122/97 -----EGGKVTGVRYQGAEG-PGELRAELTVACD----------------
Rv1751|M.tuberculosis_H37Rv -----EGGKVTGVRYQGAEG-PGELRAELTVACD----------------
MMAR_2627|M.marinum_M -----EGGRVTGVRYQGAEG-PGELRAELTVACD----------------
MSMEG_4962|M.smegmatis_MC2_155 -----DGDTVTGVRYHGPDG-PGELRADLTVACD----------------
MAB_4756c|M.abscessus_ATCC_199 -----ECGRVAGVRYESPGG-AGELRADLTLVCD----------------
MAV_4364|M.avium_104 -----EDDRVAGVRTP-----HDEVRADLVIAAD----------------
MUL_3663|M.ulcerans_Agy99 ----PDPGRVVSATYRAQSGETKHMHADLTVACD----------------
TH_1880|M.thermoresistible__bu DGGRSTVRKLAGIGFPGEPARSETLLGEMSLSADPATVAAVVAEVRKTQL
:.. : . : : .*
Mvan_0442|M.vanbaalenii_PYR-1 ---------GRGSVLRGLAGLQVREFPVSFDAWWFRLPRPADDSIYTLVP
Mflv_0304|M.gilvum_PYR-GCK ---------GRGSLLREKTGLRTQEFPVGFDVWWFRLPRPETDEMYTLFP
Mb1780|M.bovis_AF2122/97 ---------GRWSIARHEAGLKAREFPVNFDVWWFKLPR-EGDAEFSFLP
Rv1751|M.tuberculosis_H37Rv ---------GRWSIARHEAGLKAREFPVNFDVWWFKLPR-EGDAEFSFLP
MMAR_2627|M.marinum_M ---------GRWSIARQAAGLKARDYPVNFDVWWFKLPR-EGDADFSFLP
MSMEG_4962|M.smegmatis_MC2_155 ---------GRTSRVRKEAGLAPREYPVPFDVGWFRIDR-IKETAYQLTP
MAB_4756c|M.abscessus_ATCC_199 ---------GRWSLCRQEAGLVPREFSVGTDIWWFRAPR-VPGIGEELVP
MAV_4364|M.avium_104 ---------GRKSAVRAAAGLRTAQAHSPMDVLWFRLKW-RPGDPRELFG
MUL_3663|M.ulcerans_Agy99 ---------GRGSTVRSALGMATRSFGAPMDVWWFRLPR-RPDDPTGLAG
TH_1880|M.thermoresistible__bu RFGAMPLGDGVYRVIVPAEGVAGDRAEPTLDEFRRRLKAFAGTDFGAHTP
* *: * :
Mvan_0442|M.vanbaalenii_PYR-1 RIAPGKAMIVIPREGYLQIAMLIPKGTDAERRARGLDAFRADVLALLPEA
Mflv_0304|M.gilvum_PYR-GCK RLAPGRAMIVIPREGYLQIALLIEKGTDAALRAHGLDAFHADVLALLPEA
Mb1780|M.bovis_AF2122/97 RFSPGKGLGVIPREGYFQIAYLGPKGTDAQLRERGIEEFRRDVSELLPEA
Rv1751|M.tuberculosis_H37Rv RFSPGKGLGVIPREGYFQIAYLGPKGTDAQLRERGIEEFRRDVSELLPEA
MMAR_2627|M.marinum_M RFGPGKGLGVIPREGYFQIAYIGPKGTDAKLRERGIEEFRHDIGALLPEA
MSMEG_4962|M.smegmatis_MC2_155 RISSGQALILIPREGYFQAGCFLPKGGEKQLHARGLEVFRAQVAEAVPEA
MAB_4756c|M.abscessus_ATCC_199 RFKDGKLLGIIPRQGYLQIPQFIRKGDDARLRARGVEAFRRDLVDVVPEL
MAV_4364|M.avium_104 VFRKGLMMAMIYRGDYWQVAYLMPKG--ASPKGGSLEEFKERIVTAQPRL
MUL_3663|M.ulcerans_Agy99 IFNSGHGGIAIDRGDYYQIAYIIPKGSDAQLRAQGIEALHRALADLMPWL
TH_1880|M.thermoresistible__bu RWLSRFGDATRLAERYRAGRVFLAGDAAHVHPPAGGQGLNLGIQDAFNLG
* : . . : :. :
Mvan_0442|M.vanbaalenii_PYR-1 ATTIETITSLDDVKHLDVRLNRLRRWHTDGLLFIGDAAHAMSPAGG----
Mflv_0304|M.gilvum_PYR-GCK AGTVGSIASLDEVKMLDVKLNRLRCWHIEGMLCIGDAAHAMSPAGG----
Mb1780|M.bovis_AF2122/97 TASVAALASTDEVKHLNVKVNRLRRWHIDGLLCIGDAAHAMSPVAG----
Rv1751|M.tuberculosis_H37Rv TASVAALASMDEVKHLNVKVNRLRRWHIDGLLCIGDAAHAMSPVAG----
MMAR_2627|M.marinum_M AESVAGLASMDDVKHLNVKVNRLRRWHIDGLLCIGDAAHAMSPLGG----
MSMEG_4962|M.smegmatis_MC2_155 S--VDRLTSWDDVKVLDVKLNRLRRWYRDGLLCIGDAAHAMSPVGG----
MAB_4756c|M.abscessus_ATCC_199 TDVAGEIGSMDEVKLLDVRVNRLSRWYTDGLLCIGDAAHAMSGLGG----
MAV_4364|M.avium_104 REHVNDLTSWDDTSELDVRVDRLETWWRTGLLCIGDAAHAMSPAGG----
MUL_3663|M.ulcerans_Agy99 ADRVDALKSFDDVKLLDVQLNRLRRWYCDGALCIGDAAHAMSPVGG----
TH_1880|M.thermoresistible__bu WKLAAAVGGWAPDGLLDTYHAERHPVAADVLNNTRAQMELMSPEPGPRAV
: . *:. . . ** *
Mvan_0442|M.vanbaalenii_PYR-1 -----VGINVAIQDAVATARLLADPLRRGAVTERDLAAVRRRRVVPAALT
Mflv_0304|M.gilvum_PYR-GCK -----VGINLAIQDAVAAARLLAEPLRRGTVTGRDLARVRRRRILPTVVT
Mb1780|M.bovis_AF2122/97 -----VGINLAVQDAVAAATILAEPLREHRVSSRHLAAVRRRRAFPTAVT
Rv1751|M.tuberculosis_H37Rv -----VGINLAVQDAVAAATILAEPLREHRVSSRHLAAVRRRRAFPTAVT
MMAR_2627|M.marinum_M -----VGINLAVQDAVAAATILAEPLLGHRVTGRDLAAVRRRRVIPTVIT
MSMEG_4962|M.smegmatis_MC2_155 -----VGINLAIADAVAAARILAEPLRTGRVTRRDLAAVEKRRYVPAAVI
MAB_4756c|M.abscessus_ATCC_199 -----VGINLAVQDAVAAARILAAPLRRKRVTCADLAAVQRRRMFPAVVT
MAV_4364|M.avium_104 -----VGINLAVADAVAAANILCAPLQQGRVTDRDLAKVQRRRELPTRIV
MUL_3663|M.ulcerans_Agy99 -----VGINLALADAVATARMLAPSLRVGRVSTGQLARVQARRWAPTAFL
TH_1880|M.thermoresistible__bu RWLLAELMDFEEVNRYLTEKITAIGVRYHTMGDGHGLLGRRMRDIPLTGG
::. : : : . : : . . * *
Mvan_0442|M.vanbaalenii_PYR-1 QALQRQIDKR--FLRPILDGDVTGPPPALVRAI------ERAPWLTFVPA
Mflv_0304|M.gilvum_PYR-GCK QALQRLIDRR--LLGPIVRGGSGGPSPGLIRTV------ERLPWLTVIPA
Mb1780|M.bovis_AF2122/97 QAVQRVLHRR--LLGPLLQGRDPTPPAALLGLV------ERLPWLSAVPA
Rv1751|M.tuberculosis_H37Rv QAVQRVLHRR--LLGPLLQGRDPTPPAALLGLV------ERLPWLSAVPA
MMAR_2627|M.marinum_M QAVQRLLHRR--LLGPLLRGQDATPPAALLGLV------ERVPWLSVIPA
MSMEG_4962|M.smegmatis_MC2_155 QAVQRVLHIG--LRRALLGGEIRQPPERVLKAVGA--VLSRFPGLAKVPA
MAB_4756c|M.abscessus_ATCC_199 QAAQLFAHRY--LVDPVLTEKKFRGPGWLVPII------SRFRWLTVLPA
MAV_4364|M.avium_104 QAVQVLMQDN--AIAPNLNGDLS--PIHVPKIVG-------FGPLQAIPP
MUL_3663|M.ulcerans_Agy99 QGIQRAIHAA--IVAVAVTGGPPQPPPVVRLVS-------RSVPVRRIMG
TH_1880|M.thermoresistible__bu RLYARMHAGRGVLLDRTGTLSVSGWADRVDHIVDPGAALDVPAVLLRPDG
: . : :
Mvan_0442|M.vanbaalenii_PYR-1 YLVGVGVRPERAPEFAKRRPT---------
Mflv_0304|M.gilvum_PYR-GCK YLVGVGVRPERAPRFARRRPQ---------
Mb1780|M.bovis_AF2122/97 YFVGVGVRPEHAPAFARRGPGNRKGP----
Rv1751|M.tuberculosis_H37Rv YFVGVGVRPEHAPAFARRGPGNRKGP----
MMAR_2627|M.marinum_M YFVGVGVRPEHAPAFARR--GGRTD-----
MSMEG_4962|M.smegmatis_MC2_155 YLVGVGPLPEHAPDFARRSR----------
MAB_4756c|M.abscessus_ATCC_199 YFIGIGVRPEHAPDFARRAAVGTPGSMVSG
MAV_4364|M.avium_104 LVVGRGFRPEHVRTPDVHAR----------
MUL_3663|M.ulcerans_Agy99 YLVAIGPLPEHAPKYPRRAR----------
TH_1880|M.thermoresistible__bu HVAWVGADHPGQQDLTARLSRWFGAPA---
. * :