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KAVIIGAGIGGMSAAIALRQIGIDTEVYERVTENKPVGAAISVWSNGVKCLNYLGLDQQTARLGGIVETM SYAEAHSGETMCRISMQPLIEQVGQRPYPIARAELQQMLMEAYGIDDIHFGMKMVEVANQDGAATATFTD GTIASADILIGADGANSITREYVLGGPVTRRYAGYVNYNGLVEVDEAISPANEWTMYVGDGKRVSAMPPT TPRPASGRADARRWKTRWHCNGRSRTTPPTLRPRWPPIRPAAPNGPAIWYCGPVSAATSSTPRTPIPPQP GMRSCETNTAPTSFAGSSPTSWVGRSLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0460 | - | - | 100% (309) | hypothetical protein MUL_0460 |
| M. ulcerans Agy99 | MUL_2358 | - | 8e-11 | 25.77% (194) | FAD-dependent oxidoreductase |
| M. ulcerans Agy99 | MUL_1770 | - | 7e-10 | 24.31% (218) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0590c | - | 2e-06 | 26.29% (175) | hypothetical protein Mb0590c |
| M. gilvum PYR-GCK | Mflv_2621 | - | 1e-20 | 30.90% (178) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv0575c | - | 2e-06 | 26.29% (175) | hypothetical protein Rv0575c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3330 | - | 8e-21 | 29.68% (219) | putative salicylate hydroxylase |
| M. marinum M | MMAR_4944 | - | 1e-115 | 96.26% (214) | oxidoreductase |
| M. avium 104 | MAV_4429 | - | 7e-23 | 27.34% (289) | FAD binding domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4641 | - | 2e-18 | 30.73% (179) | salicylate hydroxylase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_5278 | - | 2e-95 | 79.17% (216) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4944|M.marinum_M -------MKAVIIGAGIGGMSAAIALRQIGIDTEVYERVTENKPVGAAIS
Mvan_5278|M.vanbaalenii_PYR-1 -------MKVVIVGAGMGGMSAAIALRQIGIDTVVYERVTENKPVGAAIS
MUL_0460|M.ulcerans_Agy99 -------MKAVIIGAGIGGMSAAIALRQIGIDTEVYERVTENKPVGAAIS
Mflv_2621|M.gilvum_PYR-GCK -----MSARISVIGAGISGLAAAVALERAGHHVSVIEQRTDT-GAGSGIS
MSMEG_4641|M.smegmatis_MC2_155 -----MAASFLVVGAGITGLATAAALQRRGHDVCVAEARADT-ASGAGIS
MAB_3330|M.abscessus_ATCC_1997 -------MRVAIIGAGIGGLTAAAALRANDIDVIVYEKAHELREVGAGVV
Mb0590c|M.bovis_AF2122/97 -------MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYMID
Rv0575c|M.tuberculosis_H37Rv -------MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYMID
MAV_4429|M.avium_104 MVGDARPLRVLVVGAGVAGISVARGLLRDGHDVTVFERRPRLAAAGGAVT
: ***: * : * * . * * * :
MMAR_4944|M.marinum_M VWSNGVKCLNYLGLEQQTARLGGIVETMSYAEAHSGETMCRISMQPLIEQ
Mvan_5278|M.vanbaalenii_PYR-1 VWSNGVKCLNYLGLQEETAELGGKVETMSYVDGHTGDTMCRFSMHPLIEQ
MUL_0460|M.ulcerans_Agy99 VWSNGVKCLNYLGLDQQTARLGGIVETMSYAEAHSGETMCRISMQPLIEQ
Mflv_2621|M.gilvum_PYR-GCK LWPNALAALDQIGLGDSVRDAGGRVTAGAIR-WRDGTWVRRPSVRRIVDA
MSMEG_4641|M.smegmatis_MC2_155 IWPNALAALDAIGLGDPVRAAGGRVTAGALR-WHDGTWLRHPAAERITRA
MAB_3330|M.abscessus_ATCC_1997 IANNGLRALDEVGLGDRVRAVGTQIRRTLWHTWQGESVPVPPAWPAVSPD
Mb0590c|M.bovis_AF2122/97 FWGVGYQVAKRMGITDQIAAAG-YHMEHVRSVGPTGKVKADLGVDVFRRM
Rv0575c|M.tuberculosis_H37Rv FWGVGYQVAKRMGITDQIAAAG-YHMEHVRSVGPTGKVKADLGVDVFRRM
MAV_4429|M.avium_104 VWSNGETVLRQLGVEMDG---AGRQLSSVGAVTSTGRPLATLDVTAMARR
. . :*: . .
MMAR_4944|M.marinum_M VGQRPYPIARAELQQMLMEAYGIDEIHFGMKMVEVANRDG--AATATFAD
Mvan_5278|M.vanbaalenii_PYR-1 VGQRPYPIARAELQLMLMKAYGIDDINFGMKMVGVENDTAGSAAKATFAD
MUL_0460|M.ulcerans_Agy99 VGQRPYPIARAELQQMLMEAYGIDDIHFGMKMVEVANQDG--AATATFTD
Mflv_2621|M.gilvum_PYR-GCK LGEPLVVVRRSRLTDILREALPAGTVRTGLAATRVSVGAS--SVRITLSD
MSMEG_4641|M.smegmatis_MC2_155 LGEPLVVIRRRVLTEILSGALAPGTVVHGLEAHTVETCAS--GIRVTFSD
MAB_3330|M.abscessus_ATCC_1997 RPVTSLPVHRGELQHALLGALPAGTVQLGRPCQDIVETAD--EVRIIFAD
Mb0590c|M.bovis_AF2122/97 VGDDFTSLPRGDLAAAIYTTIEDQVETIFDDSIATIDEHR-DGVRLTFER
Rv0575c|M.tuberculosis_H37Rv VGDDFTSLPRGDLAAAIYTTIEDQVETIFDDSIATIDEHR-DGVRLTFER
MAV_4429|M.avium_104 LGAPVRMVPRRVLLERLLDGFPTGRIHCDRRAVALATSRD--GVSVEFTD
: * * : :
MMAR_4944|M.marinum_M GTIASADILIGADGANSITREYVLGGPVTRRYAGYVNYNGLVEVD--EAI
Mvan_5278|M.vanbaalenii_PYR-1 GTTVSADVIIGADGAGSITREYVLGGPVSRRYAGYVNYNGLVSTD--DAI
MUL_0460|M.ulcerans_Agy99 GTIASADILIGADGANSITREYVLGGPVTRRYAGYVNYNGLVEVD--EAI
Mflv_2621|M.gilvum_PYR-GCK GEVRESDAVVGADGVNSVLAR-TLNGPLRTRYVGYTAWRGIAAHP-----
MSMEG_4641|M.smegmatis_MC2_155 GSVREASAVVGADGVDSVVAR-HLNGPLRRRYAGYTAWRGIAAHP-----
MAB_3330|M.abscessus_ATCC_1997 GSEERADVAVGADGIHSAVQR-VVADPVELSSDGIMAYRGLIPVERLDGV
Mb0590c|M.bovis_AF2122/97 TAPRDFDLVIGADGLHSNVRRLVFGP--ERDFEHYLGCKVAACVVDGYRP
Rv0575c|M.tuberculosis_H37Rv TAPRDFDLVIGADGLHSNVRRLVFGP--ERDFEHYLGCKVAACVVDGYRP
MAV_4429|M.avium_104 GTVAEGDVLIGADGLHSMVREWVGAR--HAKATGWCSWQGLVSLP---EI
. :**** * . .
MMAR_4944|M.marinum_M SPANEWTMYVGDGKRVSAMPVA---DDR-FYFFFDVVEPEGLPFEKGTAR
Mvan_5278|M.vanbaalenii_PYR-1 GPATEWTTYVGDGKRVSVMPVS---DDR-FYFFFDVVEPQGSPYEEGRVR
MUL_0460|M.ulcerans_Agy99 SPANEWTMYVGDGKRVSAMPPT---TPRPASGRADARRWKTRWHCNGRSR
Mflv_2621|M.gilvum_PYR-GCK LDPELGGETLGPGTQVGHVPLG----PDHTYWFATERTAEGGSAPGGE-H
MSMEG_4641|M.smegmatis_MC2_155 LDPELSGETMGAGVEVGHVPLG----ADHTYWFATERASQGQRSPDGE-L
MAB_3330|M.abscessus_ATCC_1997 IDLNSMQMWLGPGRSFLIYPVSRGRLLNVVAFTPSNLDAEESWTAPGD-V
Mb0590c|M.bovis_AF2122/97 RDERSYVLYNTVDRQLARFALR---GDRTMFLFVFRAEHDNPGVAPKD--
Rv0575c|M.tuberculosis_H37Rv RDERSYVLYNTVDRQLARFALR---GDRTMFLFVFRAEHDNPGVAPKD--
MAV_4429|M.avium_104 AESDAALMMIGGSGNLGLWPAG-----GAEVQWWFDLPWSTGFVRPQHPI
. . . .
MMAR_4944|M.marinum_M EVLREQFAGWAPGVQALIDKLDPTTTNRVEILDL-DPFHTWVKGRVAVLG
Mvan_5278|M.vanbaalenii_PYR-1 EVLRAHFAGWTPGVQTLIDTLDPLATNRVEILDL-DPFHTWVKGRVAVLG
MUL_0460|M.ulcerans_Agy99 TTPPTLRPRWPP--------IRPAAPNGPAIWYC-GPVS-----------
Mflv_2621|M.gilvum_PYR-GCK AYLTAKVADWADPIPRLVATTDPGDLLRNDLYDR-ARAARWSDGRAVLIG
MSMEG_4641|M.smegmatis_MC2_155 THLRRLFGSWAEPIPQLLAATDPADVLRNDLYDR-EPARCWARGPVVLAG
MAB_3330|M.abscessus_ATCC_1997 AELSAEFAGWDQPVQRVAGAMT--ETFRWGLYDR-KPLNRWTTDRIALLG
Mb0590c|M.bovis_AF2122/97 -ELRDQFGDVGWESRDILAALDDVEDLYFDVVSQ-IRMDRWSRGRVLLIG
Rv0575c|M.tuberculosis_H37Rv -ELRDQFGDVGWESRDILAALDDVEDLYFDVVSQ-IRMDRWSRGRVLLIG
MAV_4429|M.avium_104 ETIRSHFAGWSEPVDRVLAILTDEDLAASPFPHFRHPIPPPGRGRVTLLG
.
MMAR_4944|M.marinum_M DAAHNTTPDIGQGGCSAMEDAVALQWALKDNP-------TDVAAALAAYQ
Mvan_5278|M.vanbaalenii_PYR-1 DAAHNTTPDIGQGGCSAMEDAIALQWAFKDHP-------DDVHAALAAYQ
MUL_0460|M.ulcerans_Agy99 -AATSSTP------------------------------------------
Mflv_2621|M.gilvum_PYR-GCK DAAHPMRPHLGQGGCQGIEDAAILARFLELA--------DDVPTAFERFE
MSMEG_4641|M.smegmatis_MC2_155 DAAHPMRPHLGQGGCQGLEDAATLAALVARE--------PDLPTAFARFA
MAB_3330|M.abscessus_ATCC_1997 DAAHPMTPHLGQGANMSIEDAVVLATVLAGASA------TEVPRRLSLYE
Mb0590c|M.bovis_AF2122/97 DAAGCISLLGGEGTGLAITEAYVLAGELARAG-------GDHRRAFDAYE
Rv0575c|M.tuberculosis_H37Rv DAAGCISLLGGEGTGLAITEAYVLAGELARAG-------GDHRRAFDAYE
MAV_4429|M.avium_104 DAAHTMPPTLAQGTNQALLDTMVLCQALADFGRGTPGGQADVANALRWYE
**
MMAR_4944|M.marinum_M ASRTERAGDL-------VLRARKRCDVIHAKDPDTTAAWYEELRNEDGTN
Mvan_5278|M.vanbaalenii_PYR-1 SARTERAADL-------VLRARKRCDVTHAKDPQVTSRWYDELRNEDGTN
MUL_0460|M.ulcerans_Agy99 --RTPIPPQP-------GMRS---CETNTAP-----------------TS
Mflv_2621|M.gilvum_PYR-GCK AFRKPRVGML-------VREAQTLGRIVNVRPAVLSGLAGRATALIPERM
MSMEG_4641|M.smegmatis_MC2_155 TLRRRRVTRM-------VRTSRMIGRIVNLRPAVLSAAASRATVLVPEAV
MAB_3330|M.abscessus_ATCC_1997 SLRRDRTSRV-------QRNARQSGRVYRSVDLTAQQQAAQLTEILADNW
Mb0590c|M.bovis_AF2122/97 KRLRPFIEGK-------QASAAKFIWFFRHPN----PIRPVVSQRCDAHD
Rv0575c|M.tuberculosis_H37Rv KRLRPFIEGK-------QASAAKFIWFFATRTRFGLWFRNVAMRTMNFGP
MAV_4429|M.avium_104 KTRRRRVRAVSWVASLPVSHGEAVLRPAALVSDRLQAAALTMFLRWTSHR
.
MMAR_4944|M.marinum_M IIRGLVANIMGGPLTPLS----------
Mvan_5278|M.vanbaalenii_PYR-1 IIRGIVGNIVGGPLTPVTAATEG-----
MUL_0460|M.ulcerans_Agy99 FAGSSPTSWVGRSLR-------------
Mflv_2621|M.gilvum_PYR-GCK VTAHLAWIAAGSAFVLPTAADLAR----
MSMEG_4641|M.smegmatis_MC2_155 LTRQLASIAARSAFTPVD----------
MAB_3330|M.abscessus_ATCC_1997 IPDYDAAATAGTALATL-----------
Mb0590c|M.bovis_AF2122/97 ELRPAGDAVRRQRA--------------
Rv0575c|M.tuberculosis_H37Rv LATLFAGSVRDDFELPDYTW--------
MAV_4429|M.avium_104 RMSDHINRSVGEAINRSLGEAPKIPSRR