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SDHIVVVGAGIAGLATAVAIQQSGRDVVVVDDRDGTSAGYAITLWPNALAACDALGIGEDVRAASARVEA GTMRWYDGRILREPPSGKFTEAVGEPVAVTDRNQLLAILANRLTPGTVRYGARVSNVRDGLHGTSVELAD GQSLTAAAVIGADGIGSLVAQYLNGPLAFRYSGYTAWRGIADISIPDELAGLTVGPGIEFGHLPLSLGRT YWFAGERSLEAQRAPDGEIEYLARKFGNWADPIPRLLRQSRESSVLRGDVYDRGRLRRVAGGRVVLVGDA AHPMRPHLGQGGCQSLEDAAVLSVAISERSSLPSAFREYARRRRSRTRAVVSRSRHIGNVTFARPAVVGG LLTRASARIPASVFWRQLSSIAGYEAGNLAVRP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1601c | - | - | 100% (384) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_3330 | - | 1e-37 | 30.88% (353) | putative salicylate hydroxylase |
| M. abscessus ATCC 19977 | MAB_0288 | - | 4e-29 | 30.33% (366) | putative monooxygenase (salicylate/ hydroxybenzoate hydroxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0590c | - | 2e-08 | 23.88% (335) | hypothetical protein Mb0590c |
| M. gilvum PYR-GCK | Mflv_2621 | - | 2e-98 | 47.66% (384) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv0575c | - | 2e-08 | 23.88% (335) | hypothetical protein Rv0575c |
| M. leprae Br4923 | MLBr_02276 | - | 2e-05 | 30.00% (170) | putative FAD-linked oxidoreductase |
| M. marinum M | MMAR_4944 | - | 1e-31 | 27.71% (350) | oxidoreductase |
| M. avium 104 | MAV_4429 | - | 2e-29 | 28.45% (341) | FAD binding domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_4641 | - | 1e-107 | 51.46% (377) | salicylate hydroxylase |
| M. thermoresistible (build 8) | TH_0968 | - | 1e-12 | 26.94% (386) | 3-(3-hydroxy-phenyl)propionate hydroxylase |
| M. ulcerans Agy99 | MUL_2358 | - | 2e-22 | 30.91% (330) | FAD-dependent oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_3960 | - | 8e-98 | 47.66% (384) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0590c|M.bovis_AF2122/97 -------MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYMID
Rv0575c|M.tuberculosis_H37Rv -------MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYMID
MUL_2358|M.ulcerans_Agy99 -------MRVAVCGAGIAGLALAERMSALGAEVVFVERSPGPPNQGAMID
Mflv_2621|M.gilvum_PYR-GCK -----MSARISVIGAGISGLAAAVALERAGHHVSVIEQRTD-TGAGSGIS
Mvan_3960|M.vanbaalenii_PYR-1 -----MPAHTIVIGAGIAGLATAVALRRVGHDVTVIEQRTD-LTSGAGIS
MSMEG_4641|M.smegmatis_MC2_155 -----MAASFLVVGAGITGLATAAALQRRGHDVCVAEARAD-TASGAGIS
MAB_1601c|M.abscessus_ATCC_199 -----MSDHIVVVGAGIAGLATAVAIQQSGRDVVVVDDRDG-TSAGYAIT
MMAR_4944|M.marinum_M -------MKAVIIGAGIGGMSAAIALRQIGIDTEVYERVTENKPVGAAIS
MAV_4429|M.avium_104 MVGDARPLRVLVVGAGVAGISVARGLLRDGHDVTVFERRPRLAAAGGAVT
TH_0968|M.thermoresistible__bu ---MTERVDVVIVGAGPSGLTLANILGLQGVRTLVVEERDTLIDYPRGVG
MLBr_02276|M.leprae_Br4923 -MRVETSADVVVVGAGPAGSAAATWAARAGNDVIVIDSVCFPRDKACGDG
: *** * : * * . :
Mb0590c|M.bovis_AF2122/97 FWGVGYQVAKRMGITDQIA--AAGYHMEHV-RSVGPTGKVKADLGVDVFR
Rv0575c|M.tuberculosis_H37Rv FWGVGYQVAKRMGITDQIA--AAGYHMEHV-RSVGPTGKVKADLGVDVFR
MUL_2358|M.ulcerans_Agy99 LFGAGYEAADAIGILDAIR--DVSYPIGDT-GLVDELGRRRAGLPYGRIA
Mflv_2621|M.gilvum_PYR-GCK LWPNALAALDQIGLGDSVR--DAGGRVTAG-AIRWRDGTWVRRPSVRRIV
Mvan_3960|M.vanbaalenii_PYR-1 IWPNALAALDQIGLGDNVR--QAGGRVTAG-AIRWRDGTWLRRPSAQRIV
MSMEG_4641|M.smegmatis_MC2_155 IWPNALAALDAIGLGDPVR--AAGGRVTAG-ALRWHDGTWLRHPAAERIT
MAB_1601c|M.abscessus_ATCC_199 LWPNALAACDALGIGEDVR--AASARVEAG-TMRWYDGRILREPPSGKFT
MMAR_4944|M.marinum_M VWSNGVKCLNYLGLEQQTA--RLGGIVETMSYAEAHSGETMCRISMQPLI
MAV_4429|M.avium_104 VWSNGETVLRQLGVEMDG-----AGRQLSSVGAVTSTGRPLATLDVTAMA
TH_0968|M.thermoresistible__bu LDDEALRTFQSIGLVDRILPHTVPNQILRFFDAKRRLLAEMAPPDARFGW
MLBr_02276|M.leprae_Br4923 LTPRAVAELKRLGLDDWLN----TRIRHRGLRMSGFGGEVEVDWPGPSFP
. . :*:
Mb0590c|M.bovis_AF2122/97 RMVGDDFTSLPRGDLAAAIY--TTIEDQVETIFDDSIATIDEHRDGVRLT
Rv0575c|M.tuberculosis_H37Rv RMVGDDFTSLPRGDLAAAIY--TTIEDQVETIFDDSIATIDEHRDGVRLT
MUL_2358|M.ulcerans_Agy99 KALEDRLCRITRTDLHKVLL--DNLPTNVDLRFGTSVSEVTHGDDRAVVT
Mflv_2621|M.gilvum_PYR-GCK DALGEPLVVVRRSRLTDILR--EALPAG-TVRTGLAATRVSVGASSVRIT
Mvan_3960|M.vanbaalenii_PYR-1 HALGEPLVVVRRSALTEILL--DALPPD-TVQTGLSATALSIAAATARVT
MSMEG_4641|M.smegmatis_MC2_155 RALGEPLVVIRRRVLTEILS--GALAPG-TVVHGLEAHTVETCASGIRVT
MAB_1601c|M.abscessus_ATCC_199 EAVGEPVAVTDRNQLLAILA--NRLTPG-TVRYGARVSNVRDGLHGTSVE
MMAR_4944|M.marinum_M EQVGQRPYPIARAELQQMLM--EAYGID-EIHFGMKMVEVANRDGAATAT
MAV_4429|M.avium_104 RRLGAPVRMVPRRVLLERLL--DGFPTG-RIHCDRRAVALATSRDGVSVE
TH_0968|M.thermoresistible__bu PKRNGFVQPMVDAELYAGLDRFDHVEVRFGHRMQNCVEASDAGEDGVTVE
MLBr_02276|M.leprae_Br4923 STSSAVPRLELDDRIRKVAE---NSGARMLLGTKAVSVYHDSSRRAASVT
:
Mb0590c|M.bovis_AF2122/97 FERTAP-RDFDLVIGADGLHSNVRRLVFGPERDFEHYLGCKVAACVVDGY
Rv0575c|M.tuberculosis_H37Rv FERTAP-RDFDLVIGADGLHSNVRRLVFGPERDFEHYLGCKVAACVVDGY
MUL_2358|M.ulcerans_Agy99 LDDGAR-LDVDLLVGADGIHSTVRALAFGAEVQYLRYLGFHFAAFVFDAS
Mflv_2621|M.gilvum_PYR-GCK LSDGEV-RESDAVVGADGVNSVLARTLNGPLR--TRYVGYTAWRGIAAHP
Mvan_3960|M.vanbaalenii_PYR-1 LSDGRT-READAVVGADGVNSMVARALNGPLP--SRYVGYTAWRGVAAYR
MSMEG_4641|M.smegmatis_MC2_155 FSDGSV-REASAVVGADGVDSVVARHLNGPLR--RRYAGYTAWRGIAAHP
MAB_1601c|M.abscessus_ATCC_199 LADGQS-LTAAAVIGADGIGSLVAQYLNGPLA--FRYSGYTAWRGIADIS
MMAR_4944|M.marinum_M FADGTI-ASADILIGADGANSITREYVLGGPVT-RRYAGYVNYNGLVEVD
MAV_4429|M.avium_104 FTDGTV-AEGDVLIGADGLHSMVREWVGARHA---KATGWCSWQGLVSLP
TH_0968|M.thermoresistible__bu FADGHPPVRASYVVGCDGGRSTTRRLMG------VSFDGTTSSTRWLVVD
MLBr_02276|M.leprae_Br4923 LADGTE-VGCRQLIIADGARSPLGRKLGRSWH--QKTVYGVAARGYLTTP
: :: .** *
Mb0590c|M.bovis_AF2122/97 RPRDER--SYVLYNTVDRQLARFALRGDRTMFLFVFRAEHDN---PGVA-
Rv0575c|M.tuberculosis_H37Rv RPRDER--SYVLYNTVDRQLARFALRGDRTMFLFVFRAEHDN---PGVA-
MUL_2358|M.ulcerans_Agy99 DMDDTAGDHVVITDTVDRQLGLYALRNGQTAVFAAYRAADPE---PPPD-
Mflv_2621|M.gilvum_PYR-GCK LDPELGG----ETLGPGTQVGHVPLGPDHTYWFATERTAEGG---SAPGG
Mvan_3960|M.vanbaalenii_PYR-1 LDPALAG----ETMSAGTEVGHVPLGPDHTYWFATERTREGS---RSAGG
MSMEG_4641|M.smegmatis_MC2_155 LDPELSG----ETMGAGVEVGHVPLGADHTYWFATERASQGQ---RSPDG
MAB_1601c|M.abscessus_ATCC_199 IPDELAG----LTVGPGIEFGHLPLSLGRTYWFAGERSLEAQ---RAPDG
MMAR_4944|M.marinum_M EAISPAN-EWTMYVGDGKRVSAMPVADDRFYFFFDVVEPEGL---PFEKG
MAV_4429|M.avium_104 EIAESDA--ALMMIGGSGNLGLWPAGGAEVQWWFDLPWSTGF---VRPQH
TH_0968|M.thermoresistible__bu VANDPLG-HPNSEVGADPARPYVSISIAHGIRRFEFMIHPHE---TDAEV
MLBr_02276|M.leprae_Br4923 RSDDLWL---TSHLELRSPDGAVLPGYGWIFPLGNGEVNIGVGALSTSKR
Mb0590c|M.bovis_AF2122/97 -PKDELRDQFGDVGWESRDILAALDDVEDLYFDVVSQ-IRMDR-WSRGRV
Rv0575c|M.tuberculosis_H37Rv -PKDELRDQFGDVGWESRDILAALDDVEDLYFDVVSQ-IRMDR-WSRGRV
MUL_2358|M.ulcerans_Agy99 -ARAALRDRFAGMGWLVPEVLERCPPSGDIYFGQVAQ-VEMPR-WSTNRV
Mflv_2621|M.gilvum_PYR-GCK -EHAYLTAKVADWADPIPRLVATTDPGDLLRNDLYDR-ARAAR-WSDGRA
Mvan_3960|M.vanbaalenii_PYR-1 -EHAYLTAKLAGWADPIPALLASTDPADVLRNDLYDR-AQPRD-WSRGPA
MSMEG_4641|M.smegmatis_MC2_155 -ELTHLRRLFGSWAEPIPQLLAATDPADVLRNDLYDR-EPARC-WARGPV
MAB_1601c|M.abscessus_ATCC_199 -EIEYLARKFGNWADPIPRLLRQSRESSVLRGDVYDR-GRLRR-VAGGRV
MMAR_4944|M.marinum_M TAREVLREQFAGWAPGVQALIDKLDPTTTNRVEILDL-DPFHT-WVKGRV
MAV_4429|M.avium_104 -PIETIRSHFAGWSEPVDRVLAILTDEDLAASPFPHFRHPIPP-PGRGRV
TH_0968|M.thermoresistible__bu DDPAFVRRMLG-------RRIPYPERVDMIRYRVYTHHSRIAGSFRKGRL
MLBr_02276|M.leprae_Br4923 PADLALRSLISYYTDLRRHEWGFSGQPRAVSSALLPMGGAVSG-VAGPNW
: ..
Mb0590c|M.bovis_AF2122/97 LLIGDAAGCISLLGGEGTGLAITEAYVLAGELARAGG-------DHRRAF
Rv0575c|M.tuberculosis_H37Rv LLIGDAAGCISLLGGEGTGLAITEAYVLAGELARAGG-------DHRRAF
MUL_2358|M.ulcerans_Agy99 VLVGDACSAGSPLTGPGASLALAGAYVLSEQLRRTS--------SVERAL
Mflv_2621|M.gilvum_PYR-GCK VLIGDAAHPMRPHLGQGGCQGIEDAAILARFLELAD--------DVPTAF
Mvan_3960|M.vanbaalenii_PYR-1 VIVGDAAHPMRPHLGQGGCQGLEDAAILARFVGLSP--------DLPAAF
MSMEG_4641|M.smegmatis_MC2_155 VLAGDAAHPMRPHLGQGGCQGLEDAATLAALVAREP--------DLPTAF
MAB_1601c|M.abscessus_ATCC_199 VLVGDAAHPMRPHLGQGGCQSLEDAAVLSVAISERS--------SLPSAF
MMAR_4944|M.marinum_M AVLGDAAHNTTPDIGQGGCSAMEDAVALQWALKDNPT-------DVAAAL
MAV_4429|M.avium_104 TLLGDAAHTMPPTLAQGTNQALLDTMVLCQALADFGRGTPGGQADVANAL
TH_0968|M.thermoresistible__bu LLAGDAAHLMPVWQGQGYNSGIRDAANLGWKLAAVVNG-----HAHDALL
MLBr_02276|M.leprae_Br4923 MLIGDAAACVNPLNGEGIDYGLETGRLAAELLDLRDLS-----YVWPSLL
: ***. . * .: : :
Mb0590c|M.bovis_AF2122/97 DAYEKRLRPFIEGKQASA--------AKFIWFFRHPN----PIRPVVSQR
Rv0575c|M.tuberculosis_H37Rv DAYEKRLRPFIEGKQASA--------AKFIWFFATRTRFGLWFRNVAMRT
MUL_2358|M.ulcerans_Agy99 DFYERLWSPTVEEKQESA--------RGLR----------LDAVAVVLTA
Mflv_2621|M.gilvum_PYR-GCK ERFEAFRKPRVGMLVREA--------QTLGRIVNVRPAVLSGLAGRATAL
Mvan_3960|M.vanbaalenii_PYR-1 DRFGAFRRRRVRPLVRES--------AAIGRIVNLRPAFLSGVASRASAL
MSMEG_4641|M.smegmatis_MC2_155 ARFATLRRRRVTRMVRTS--------RMIGRIVNLRPAVLSAAASRATVL
MAB_1601c|M.abscessus_ATCC_199 REYARRRRSRTRAVVSRS--------RHIGNVTFARPAVVGGLLTRASAR
MMAR_4944|M.marinum_M AAYQASRTERAGDLVLRA--------RKRCDVIHAKDPDTTAAWYEELRN
MAV_4429|M.avium_104 RWYEKTRRRRVRAVSWVASLPVSHGEAVLRPAALVSDRLQAAALTMFLRW
TH_0968|M.thermoresistible__bu DTYDLERREHARAMIDLSTMVGRVISPTNRRVAALRDRLIHAASVVPTLK
MLBr_02276|M.leprae_Br4923 QQHYGRGFSVARRLALLLTFKR--CLPAIGPSAMRSTSLITIAVRVMANL
.
Mb0590c|M.bovis_AF2122/97 -----CDAHDELRPAGDAVRRQRA--------------------------
Rv0575c|M.tuberculosis_H37Rv -----MNFGPLATLFAGSVRDDFELPDYTW--------------------
MUL_2358|M.ulcerans_Agy99 -----LDSPRRAALHLAPADQPIR--------------------------
Mflv_2621|M.gilvum_PYR-GCK -----IPERMVTAHLAWIAAGSAFVLPTAADLAR----------------
Mvan_3960|M.vanbaalenii_PYR-1 -----IPEWAVASHLASIAAGSAFILPTAGDVGG----------------
MSMEG_4641|M.smegmatis_MC2_155 -----VPEAVLTRQLASIAARSAFTPVD----------------------
MAB_1601c|M.abscessus_ATCC_199 -----IPASVFWRQLSSIAGYEAGNLAVRP--------------------
MMAR_4944|M.marinum_M -----EDGTNIIRGLVANIMGGPLTPLS----------------------
MAV_4429|M.avium_104 -----TSHRRMSDHINRSVGEAINRSLGEAPKIPSRR-------------
TH_0968|M.thermoresistible__bu RYVLEMRFKPMPRYLQGAVYHGGPRSKSSPTGTLFIQPRVDTRDAENVLL
MLBr_02276|M.leprae_Br4923 VT---DDDADWVARVWRSGGWASWLVDRRPPFS-----------------
Mb0590c|M.bovis_AF2122/97 --------------------------------------------------
Rv0575c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2358|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3960|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4641|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1601c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4944|M.marinum_M --------------------------------------------------
MAV_4429|M.avium_104 --------------------------------------------------
TH_0968|M.thermoresistible__bu DDVLGPGFAVLCWSNNLRAVLGEDAFSHWKSLGATFVEARPITQLHWPGH
MLBr_02276|M.leprae_Br4923 --------------------------------------------------
Mb0590c|M.bovis_AF2122/97 --------------------------------------------------
Rv0575c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_2358|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3960|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4641|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1601c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4944|M.marinum_M --------------------------------------------------
MAV_4429|M.avium_104 --------------------------------------------------
TH_0968|M.thermoresistible__bu DDPDVVVVGDRTGALKGWFDVHTDSVLFLRPDRCIAAACIAQRAPETSAA
MLBr_02276|M.leprae_Br4923 --------------------------------------------------
Mb0590c|M.bovis_AF2122/97 -------------------------------------
Rv0575c|M.tuberculosis_H37Rv -------------------------------------
MUL_2358|M.ulcerans_Agy99 -------------------------------------
Mflv_2621|M.gilvum_PYR-GCK -------------------------------------
Mvan_3960|M.vanbaalenii_PYR-1 -------------------------------------
MSMEG_4641|M.smegmatis_MC2_155 -------------------------------------
MAB_1601c|M.abscessus_ATCC_199 -------------------------------------
MMAR_4944|M.marinum_M -------------------------------------
MAV_4429|M.avium_104 -------------------------------------
TH_0968|M.thermoresistible__bu LSEVMCLTQGGGNGAASPVLHVAQSAAEPSGTATRST
MLBr_02276|M.leprae_Br4923 -------------------------------------