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MEAAYRCLADPHAGPVSMAAILGTAGVSSRAFYRHFESKDDLFLALLEQECSAVVGQVDRVADAAQGSPA DQLAAWIEAMFDIVVDPRQRLQLTVIDSEEVRTAKGYRQTRDRLHAARERGLAEILRRGLRDGSFPLTEP EADAVAINAVVSRVLNTQTTDEPEARKKALVAVLDFALRAVGAAAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2097 | - | - | 100% (186) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1640 | - | 3e-07 | 26.55% (177) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_3791 | - | 8e-07 | 26.32% (152) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0080 | - | 1e-06 | 27.61% (163) | transcriptional regulatory protein |
| M. tuberculosis H37Rv | Rv0078 | - | 1e-06 | 27.61% (163) | transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_00815 | - | 1e-05 | 28.72% (94) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4449c | - | 3e-06 | 32.89% (149) | TetR family transcriptional regulator |
| M. marinum M | MMAR_1569 | - | 2e-11 | 28.40% (169) | putative regulatory protein |
| M. avium 104 | MAV_1858 | - | 2e-18 | 36.81% (163) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_0343 | - | 5e-07 | 34.62% (78) | TetR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_2894 | - | 6e-52 | 54.10% (183) | PUTATIVE transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_3464 | - | 3e-11 | 28.40% (169) | putative regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_4608 | - | 4e-79 | 78.69% (183) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2097|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4608|M.vanbaalenii_PYR-1 -----------------------------------------------MQP
TH_2894|M.thermoresistible__bu -----------------------------------------------VAT
Mb0080|M.bovis_AF2122/97 ------------------------------------------MEIKRRTQ
Rv0078|M.tuberculosis_H37Rv ------------------------------------------MEIKRRTQ
MMAR_1569|M.marinum_M MSDIAATMKCRLRVSRKRLVGTYGSMTHPNNPGTRRQADLSSRLTRRRHK
MUL_3464|M.ulcerans_Agy99 MSDIAATMKCRLRVSRKRLVGTYGSMTHPNNPGTRRQADLSSRLTRRRHK
MAV_1858|M.avium_104 ------------------------------------------------MS
MLBr_00815|M.leprae_Br4923 -----------------MNNLAKAAQRRTVRPIDRGRLSDDIATPNQRSN
MAB_4449c|M.abscessus_ATCC_199 --------------------------------------------MAGGTK
MSMEG_0343|M.smegmatis_MC2_155 -------------------------------MHSGGVLIVVDSPPGTAKA
Mflv_2097|M.gilvum_PYR-GCK -----------MEAAYRCLADPHAGP-----VSMAAILGTAGVSSRAFYR
Mvan_4608|M.vanbaalenii_PYR-1 GPDHDGDRRRIIEAAYRCLAQPHAGP-----IPMTSILRSAGLSSRAFYR
TH_2894|M.thermoresistible__bu DSPASEDRKRIIDAAYQCLSERHVNP-----VSVAAILARAECSSRAFYR
Mb0080|M.bovis_AF2122/97 EERSAATREALITGARKLWGLRGYAE-----VGTPEIATEAGVTRGAMYH
Rv0078|M.tuberculosis_H37Rv EERSAATREALITGARKLWGLRGYAE-----VGTPEIATEAGVTRGAMYH
MMAR_1569|M.marinum_M LAPDPGIRRAILVAASMSVREHGVRG-----LSVATVLDRAQLSTRAFYR
MUL_3464|M.ulcerans_Agy99 LAPDPGIRRAILVAASMSVREHGVRG-----LSVATVLDRAQLSTRAFYR
MAV_1858|M.avium_104 DHRRPTERDAIMRAAYRLISEGAAGPSASSSTSIENILRVARVNRRVFYR
MLBr_00815|M.leprae_Br4923 RLSRDKRRGQLLIVASDVFVDHGYHA-----AGMDEIADRAGVSKPVLYQ
MAB_4449c|M.abscessus_ATCC_199 RLPRAVREQQMLDAAVQEFALNGFRD-----TSMDAIAAAAKISKPMLYL
MSMEG_0343|M.smegmatis_MC2_155 RTRDPDRKNRILLAASELIGRRGFHA-----VSIADIGNAAGITGSGVYR
: * : * . .*
Mflv_2097|M.gilvum_PYR-GCK HFESKDDLFLALLEQECSAVVGQVDRVADAA-QGSPADQLAAWIEAMFDI
Mvan_4608|M.vanbaalenii_PYR-1 HFLSKDDLFLALLRQECEAVIAQVDRIADAA-VGSPADQLADWIAAMFDI
TH_2894|M.thermoresistible__bu HFESKDALFLAMVEEESAALTRRLDRIVAEH-PGTPIEQLQAWVEQLFAL
Mb0080|M.bovis_AF2122/97 QFADKAALFRDVVEVVEQDVMARMATLVAASGAATPADAIRAAVDAWLEV
Rv0078|M.tuberculosis_H37Rv QFADKAALFRDVVEVVEQDVMARMATLVAASGAATPADAIRAAVDAWLEV
MMAR_1569|M.marinum_M HFESKDQLVAAVFLEVARVEAVRLRTLMAKA--TNPIEGVAAWIDGRLDL
MUL_3464|M.ulcerans_Agy99 HFESKDQLVAAMFLEVARVEAVRLRTLMAKA--TNPIEGVAAWIDGRLDL
MAV_1858|M.avium_104 HFASKDDLIIAMQEWAGDLILADLQKAVAAA--DTPAAAVAAWIEDYLSI
MLBr_00815|M.leprae_Br4923 HFSSKLELYLAVLERHMNNLVSSVQQALRTT--TNNRQRLHAAVQAFFDF
MAB_4449c|M.abscessus_ATCC_199 YYGSKEDLFVACLRRELGRFVEAVRGDIDLT--QSPRDVLSTTVVSFLNY
MSMEG_0343|M.smegmatis_MC2_155 HFESKSAILVALFDQVIDDLIAEEKRILDET--DDLPTALAELIEGQVEF
: .* : : : .
Mflv_2097|M.gilvum_PYR-GCK VVDPRQRLQLTVIDSEEVRTAKGYRQTRDRLHAARERGLAEILRRGLRDG
Mvan_4608|M.vanbaalenii_PYR-1 IVDPQQRLQLTVIDSDEVRAAKGYREMRERLHAERERSLAEILRRGRRDG
TH_2894|M.thermoresistible__bu VYDPALREHMQVIDSDEVRSAKGFREVRERAHIERERSLRTILTRGRADG
Mb0080|M.bovis_AF2122/97 SGDPEVR-QLVLLDAPVVLGWAGFRDVAQRYSLGMTEQLITEAIRAGQLA
Rv0078|M.tuberculosis_H37Rv SGDPEVR-QLILLDAPVVLGWAGFRDVAQRYSLGMTEQLITEAIRAGQLA
MMAR_1569|M.marinum_M AFDDAVKADLRHLSMDAQSHLLNTPELVEPAYAETLEPLIEQLHLGVAQE
MUL_3464|M.ulcerans_Agy99 AFDDAVKADLRHLSMGAQSHLLNAPELVEPAYAETLEPLIEQLHLGVAQE
MAV_1858|M.avium_104 GWQEARFRDALAFMSAEVIGAPGIAAALEVTYDRHRAVLTEALAAGLADG
MLBr_00815|M.leprae_Br4923 IEHDGQGYRLIFENDN-----ITEPRVAAQVRVATESCIDAVFALISADS
MAB_4449c|M.abscessus_ATCC_199 VDTHRASWIVIYGQAT------STQLFAKQVREGRDRIIELVARLIKAAS
MSMEG_0343|M.smegmatis_MC2_155 VIGDRQLAQVYHNEIN------NLPEEDRRRLRRKQRLYLEEWVHLVNEL
Mflv_2097|M.gilvum_PYR-GCK SFPLTEPEADAVAINAVVSRVLNTQTTD-EPEARKKALVAVLDFALRAVG
Mvan_4608|M.vanbaalenii_PYR-1 SFPLAEPEIDAVAVNALVSRLLVRQTTD-DPQARKQAEVAVLDFALRAVG
TH_2894|M.thermoresistible__bu SMPLTDPECDAVAIGAVVARALLEQTDL-TDDEYRVGVECVMDFALRAIG
Mb0080|M.bovis_AF2122/97 RQPVRP--LAQVLIGALDEAAMFIATAD-DPKRARRETRQVLRRLIDGML
Rv0078|M.tuberculosis_H37Rv RQPVRP--LAQVLIGALDEAAMFIATAD-DPKRARRETRQVLRRLIDGML
MMAR_1569|M.marinum_M VFHDVDPHSEARSIQGVVWANTEQQWAS-GDCRRDEVRESTVRFCLRGLG
MUL_3464|M.ulcerans_Agy99 VFHDVDPHSEARSIQGVVWANTEQQWAS-GDCRRDEVRESTVRFCLRGLG
MAV_1858|M.avium_104 SLPNAHPELDSFAIHAVTVRHLEARIRGRLDSDFREVRDQIVTLMLTGLS
MLBr_00815|M.leprae_Br4923 RLDPHRARMVAVGLVGISVDCARYWLDTNRPISKSDAVEGTVQFAWGGLS
MAB_4449c|M.abscessus_ATCC_199 PEIDPETDYDAMAVALVGGGEAVASRVATGDIKVESAKDTLLNLGWRGLR
MSMEG_0343|M.smegmatis_MC2_155 REDLDDTEARVIVHAAIG--AIQSPLFHNTGLADDRLRVLLADSARSILS
: :
Mflv_2097|M.gilvum_PYR-GCK AAAR---------
Mvan_4608|M.vanbaalenii_PYR-1 AVPGGQDTRR---
TH_2894|M.thermoresistible__bu ADHTPYRR-----
Mb0080|M.bovis_AF2122/97 NG-----------
Rv0078|M.tuberculosis_H37Rv NG-----------
MMAR_1569|M.marinum_M VAPDTIAQITAPD
MUL_3464|M.ulcerans_Agy99 VAPDTIAQITAPD
MAV_1858|M.avium_104 APAVYRTATR---
MLBr_00815|M.leprae_Br4923 HVPLTRL------
MAB_4449c|M.abscessus_ATCC_199 GRPRDEPVAKRA-
MSMEG_0343|M.smegmatis_MC2_155 TDRRTP-------