For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MSAKAQPDPTVRQDPAVRQDRAQSRAGRFMRSALDILGETGRTDFTVLEVVERSKTSLRAFYQHFSTKDE LLLALVEKIMAEATERWRAETEQLAGPDALRVLIDRISAPAQSSTQDSINRGLTYYNDHLLETRPKEFAT VLAPLHRLLGDILRRGIAEGSFRADLDVDTDAAILMQTVLGTLRLRELGADLNGIPIEGSHVHTFCLRGL TPP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3791 | - | - | 100% (213) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2432 | - | 3e-21 | 35.14% (222) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2097 | - | 9e-07 | 26.32% (152) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3587c | - | 6e-07 | 23.04% (204) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3557c | - | 6e-07 | 23.04% (204) | TetR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3372 | - | 1e-06 | 26.63% (184) | TetR family transcriptional regulator |
| M. marinum M | MMAR_3987 | - | 3e-61 | 61.50% (187) | putative transcriptional regulatory protein |
| M. avium 104 | MAV_1626 | - | 4e-60 | 58.33% (192) | hypothetical protein MAV_1626 |
| M. smegmatis MC2 155 | MSMEG_2995 | - | 9e-76 | 65.85% (205) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_0537 | - | 6e-68 | 65.66% (198) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_3848 | - | 1e-61 | 61.50% (187) | putative transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_2603 | - | 8e-95 | 81.04% (211) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3587c|M.bovis_AF2122/97 MDRVAG----------QVN-----------SRRGELLELAAAMFAERGLR
Rv3557c|M.tuberculosis_H37Rv MDRVAG----------QVN-----------SRRGELLELAAAMFAERGLR
Mflv_3791|M.gilvum_PYR-GCK MSAKAQPDPTVRQDPAVRQDR-------AQSRAGRFMRSALDILGETGRT
Mvan_2603|M.vanbaalenii_PYR-1 MSAKAQPSPTAQRDGAQQE-----------SRASRFMRSALDILGETGRT
MSMEG_2995|M.smegmatis_MC2_155 MARPTQRSPDGAR--ADPE-----------DRTARFMRSALAILGETGRT
TH_0537|M.thermoresistible__bu MANPTS---------ADTE-----------SRADRFLRSALTILGETGRT
MMAR_3987|M.marinum_M MAGPSE----------QVEA----------TRADRFIKTAVEILGETGRT
MUL_3848|M.ulcerans_Agy99 MAGPSE----------QVEA----------TRADRFIKTAVEILGETGRT
MAV_1626|M.avium_104 MAEPNE----------DVEI----------TRGDRFIKTAVAILGETGRT
MAB_3372|M.abscessus_ATCC_1997 MAILAFGEGFDIMSSSRLQPRKQPRQDRAEATRRRILEAAAHVFADFGYA
* : .::. * ::.: *
Mb3587c|M.bovis_AF2122/97 ATTVRDIADGAGILSGSLYHHFASKEEMVDELLRGFLDWLFARYRDIVDS
Rv3557c|M.tuberculosis_H37Rv ATTVRDIADGAGILSGSLYHHFASKEEMVDELLRGFLDWLFARYRDIVDS
Mflv_3791|M.gilvum_PYR-GCK DFTVLEVVERSKTSLRAFYQHFSTKDELLLALVEKIMAEATERWRAETEQ
Mvan_2603|M.vanbaalenii_PYR-1 DFTVLEVVERSKTSLRAFYQHFATKDELLLALVERVMVDATERWRAETDR
MSMEG_2995|M.smegmatis_MC2_155 DFTVLEVVERSKTSLRSFYQHFSSKDELLLALIDRIMAESAQRWRADTEA
TH_0537|M.thermoresistible__bu DFTVLEVVERSKTSLRSFYQHFSTKDELLLALIDTIMAESAARWRAELEG
MMAR_3987|M.marinum_M DFTVQEVVTRSKTSLRAFYQHFSSKDELLLALFDRTMSQTAQLWRAEAAG
MUL_3848|M.ulcerans_Agy99 DFTVQEVVTRSKTSLRAFYQHFSSKDELLLALFDRTMSQTAQLWRAEAAG
MAV_1626|M.avium_104 DFTVQEVVARSKTSLRAFYQHFSSKDELLLALFDRTIAQSAQTWRAETAG
MAB_3372|M.abscessus_ATCC_1997 AGTTNRIAERAEISIGSLYQYFPNKDAILVELMTAHTHRGFALIHQHLA-
*. :. : ::*::*..*: :: *. :
Mb3587c|M.bovis_AF2122/97 TANP--LERLQGLFMASFEAIEHHHAQVVIYQDEAQRLASQPRFSYIEDR
Rv3557c|M.tuberculosis_H37Rv TANP--LERLQGLFMASFEAIEHHHAQVVIYQDEAQRLASQPRFSYIEDR
Mflv_3791|M.gilvum_PYR-GCK LAGPDALRVLIDRISAPAQSSTQDSINRGLTYYNDHLLETRPKE--FATV
Mvan_2603|M.vanbaalenii_PYR-1 MTSDDALRLLIERISAPAESSTQDSINRGLTYYNDHLLETRPKE--FAKV
MSMEG_2995|M.smegmatis_MC2_155 LPGPEALRVLVEKITAPASSSTQDSINRGLTYYNDHLAESLPRE--YARV
TH_0537|M.thermoresistible__bu LPAAQALRTLIERICTPAGSSRQDYINRGLTSYNDRLADTLPRE--YARV
MMAR_3987|M.marinum_M LDSTAALKLVIDRISAQPESSTQDSLNRALSLYNQHLAETRPRE--YARV
MUL_3848|M.ulcerans_Agy99 LDSTAALKLVIDRISAQPESSTQDSLNRALSLYNQHLAETRPRE--YARV
MAV_1626|M.avium_104 LDSTAALKLVIDRVSQQPESSTQDSLNRALTLYNQHLAETRPRE--YARV
MAB_3372|M.abscessus_ATCC_1997 AGLPDTIEDTVRVFVGSAIANHRDSPR-----LHRVLFEEAPRP---PEF
:. . : :. . . *:
Mb3587c|M.bovis_AF2122/97 NKQQRKMWVDVLNQGIEEGYFRP----------DLDVDLVYRFIRDTTWV
Rv3557c|M.tuberculosis_H37Rv NKQQRKMWVDVLNQGIEEGYFRP----------DLDVDLVYRFIRDTTWV
Mflv_3791|M.gilvum_PYR-GCK LAPLHRLLGDILRRGIAEGSFRA----------DLDVDTDAAILMQTVLG
Mvan_2603|M.vanbaalenii_PYR-1 LAPLHRLVADILRRGIDEGTFRA----------DLDVDTDAAILMHTVLG
MSMEG_2995|M.smegmatis_MC2_155 LAPLHDLIRGIVRRGIDAGDFHS----------GVEVDTTSALILQSVLG
TH_0537|M.thermoresistible__bu LAPLHQLIVDILRRGVAEGAFRGPGETAPDGGVDADLDAVAALIMQTALG
MMAR_3987|M.marinum_M LSPLHRLIRDIVGQGITEGMFNP----------GLDVGAAAAIVMQTVLG
MUL_3848|M.ulcerans_Agy99 LSPLHRLIRDIVGQGITEGMFNP----------GLDVGAAAAIVMQTVLG
MAV_1626|M.avium_104 LSPLHRLIRDIVGQGITEGVFNP----------GLDVGAAAAIVMQTMMG
MAB_3372|M.abscessus_ATCC_1997 LAMLHRSEDAVIAAAEAVLAAHPEVR-------VTETDTAARMVVATIES
: :: . . : . :: :
Mb3587c|M.bovis_AF2122/97 SVRWYRPGGPLTAQQVG-QQYLAIVLGGITKEGV----------------
Rv3557c|M.tuberculosis_H37Rv SVRWYRPGGPLTAQQVG-QQYLAIVLGGITKEGV----------------
Mflv_3791|M.gilvum_PYR-GCK TLRLRELGADLNGIPIEGSHVHTFCLRGLTPP------------------
Mvan_2603|M.vanbaalenii_PYR-1 VLRLRDLGAELNGVPIVGDHVHTFCVRGLTG-------------------
MSMEG_2995|M.smegmatis_MC2_155 AMRLRSLGVELNGTPIEGPHIYEFCVRSLSNPPTPDDQAFPRRP------
TH_0537|M.thermoresistible__bu AMRLRALGAELGGAPIDAELIYTFCLHGLAR--TTDS-------------
MMAR_3987|M.marinum_M ALRLRWLGTELNATPIDAGELYEFCSRALGVRDAEESA-ASSLTELFAQI
MUL_3848|M.ulcerans_Agy99 ALRLRWLGTELNAMPIDAGELYEFCSRALGVRDTEESA-ASSLTELFAQI
MAV_1626|M.avium_104 AQRLHWLGAELNGTPVDAGQLYDFCSRALGIRDTDEDAGAPSLAELFGQI
MAB_3372|M.abscessus_ATCC_1997 LVHRLIAGPRPIDPQLFEDQLVDMLTRYLTG-------------------
: * : : :
Mb3587c|M.bovis_AF2122/97 --------------------------------------------------
Rv3557c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_3791|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2603|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2995|M.smegmatis_MC2_155 --------------------------------------------------
TH_0537|M.thermoresistible__bu --------------------------------------------------
MMAR_3987|M.marinum_M GMRQEPSHDDGFAMTMPVSPQVVNTSGALQGGLIATLADVAGGQLGLQYL
MUL_3848|M.ulcerans_Agy99 GMRQEPSHDDGFAMTMPVSPQVVNTSGALQGGLIATLADVAGGQLGLQYL
MAV_1626|M.avium_104 GMRPG-TRNGQFAMTMPVSPAVVNTSGALQGGLIATLVDVAGGQFGLDYL
MAB_3372|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3587c|M.bovis_AF2122/97 --------------------------------------------------
Rv3557c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_3791|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2603|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2995|M.smegmatis_MC2_155 --------------------------------------------------
TH_0537|M.thermoresistible__bu --------------------------------------------------
MMAR_3987|M.marinum_M PPGAAMTTADLFIRYLRPIRQGAARAVPRMLRAGRRALVMQVDIFGDSAD
MUL_3848|M.ulcerans_Agy99 PPGAAMTTADLFIRYLRPIRQGAARAVPRMLRAGRRALVMQVDIFGDSAD
MAV_1626|M.avium_104 RPGTTMTTADLFVRYLRPVRQGSAFAVPRMLRSGRRAMVMQVDIFGDGDD
MAB_3372|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3587c|M.bovis_AF2122/97 ---------------------------
Rv3557c|M.tuberculosis_H37Rv ---------------------------
Mflv_3791|M.gilvum_PYR-GCK ---------------------------
Mvan_2603|M.vanbaalenii_PYR-1 ---------------------------
MSMEG_2995|M.smegmatis_MC2_155 ---------------------------
TH_0537|M.thermoresistible__bu ---------------------------
MMAR_3987|M.marinum_M ELAATATVNFAIIDRNDTTETG-----
MUL_3848|M.ulcerans_Agy99 ELAATATVNFAIIDRNDTTETG-----
MAV_1626|M.avium_104 ELLATATVNFAIIN-GDTPSSGLPPAE
MAB_3372|M.abscessus_ATCC_1997 ---------------------------