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PQPVRQQARTSVRKQQLSQAAARLFTDRGYHNVSMDDIASAVGLTGPALYRHFRKKHDILMQVISEQLGA VEAVAARAVDAGPTDERAEVFLAALADLLLEREQVLLWKRERRQLAEEAQRQCRLKLSDVLRLSSQALGL TSGEKPSGQAELRTWAVLGIYSSVAPIRNRVENATAKRLLRAAALNILGCELDTGLPRSATPVTHRRQPP GRRERILSTAGRLFHAQSYHAVGIEEIAAESDTAIATFYQYFNGKGELLHALLNRGAEGLHYVTNHRLAS AATAQDALDTVASTLIELALGPHQPILAILAADLVYLPDAARELIRMSEREYTDEWVAALVGVCPELTPP HARLLARAAIGLITDITQIQKMRMRPGIATELHQLVNAVLAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1640 | - | - | 100% (393) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0186 | - | 6e-35 | 27.06% (388) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0013 | - | 7e-34 | 30.03% (373) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1998c | - | 7e-32 | 27.68% (401) | transcriptional regulatory protein |
| M. tuberculosis H37Rv | Rv1963c | mce3R | 7e-32 | 27.68% (401) | transcriptional repressor (probably TETR-family) MCE3R |
| M. leprae Br4923 | MLBr_00815 | - | 2e-09 | 25.00% (208) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2061c | - | 7e-17 | 32.97% (182) | TetR family transcriptional regulator |
| M. marinum M | MMAR_2873 | mce3R | 3e-30 | 27.05% (403) | TetR family transcriptional regulator |
| M. avium 104 | MAV_0110 | - | 1e-32 | 28.38% (370) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_0815 | - | 6e-29 | 26.20% (397) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2795 | - | 3e-25 | 26.53% (392) | PUTATIVE transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_2880 | mce3R | 1e-29 | 27.05% (403) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_3985 | - | 1e-40 | 31.62% (389) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_0110|M.avium_104 --------------------------------------------------
TH_2795|M.thermoresistible__bu --------------------------------------------------
MSMEG_0815|M.smegmatis_MC2_155 MHAPENSSTGQGAMALRNDTTASRLSMLRGWSMCVLDQMTPTYVNDRSPW
Mb1998c|M.bovis_AF2122/97 --------------------------------------------------
Rv1963c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2873|M.marinum_M --------------------------------------------------
MUL_2880|M.ulcerans_Agy99 --------------------------------------------------
MAB_2061c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1640|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3985|M.vanbaalenii_PYR-1 --------------------------------------------MATRIR
MLBr_00815|M.leprae_Br4923 ------------------------------------------------MN
MAV_0110|M.avium_104 ------------------------------MKRRPKDRKVQIARAATDAF
TH_2795|M.thermoresistible__bu -------------------MSAAGSDAHRNGRHRPKNRKALIARASADAF
MSMEG_0815|M.smegmatis_MC2_155 VRAFDRIGGPVYRDHMARTPLGPTTSGSVAVRRRPKDRKAQIARASAEAF
Mb1998c|M.bovis_AF2122/97 -----------------------MASVAQPVRRRPKDRKKQILDQAVGLF
Rv1963c|M.tuberculosis_H37Rv -----------------------MASVAQPVRRRPKDRKKQILDQAVGLF
MMAR_2873|M.marinum_M -----------------------MDSVVAPVRRRPKDRKQQILEQAVGLF
MUL_2880|M.ulcerans_Agy99 -----------------------MDSVVAPVRRRPKDRKQQILEQAVGLF
MAB_2061c|M.abscessus_ATCC_199 ---------------------------------MAGLRRKLLLEAAADLF
Mflv_1640|M.gilvum_PYR-GCK ------------------------MPQPVRQQARTSVRKQQLSQAAARLF
Mvan_3985|M.vanbaalenii_PYR-1 GDRAIGCRVSRSHGAAEEGAEGVTSVARPERGTRPSNRRELIGAAATELF
MLBr_00815|M.leprae_Br4923 NLAKAAQRRTVRPIDRGRLSDDIATPNQRSNRLSRDKRRGQLLIVASDVF
*: : : *
MAV_0110|M.avium_104 SELGYHAVSMENIAARVGISAAALYRHSQGKYDLFREVFLALGQQLVDAT
TH_2795|M.thermoresistible__bu GAQGYHAVSMEEIAARVGISPAALYRHSQGKYDLFRDSVLGLGQLLVDAT
MSMEG_0815|M.smegmatis_MC2_155 SALGYHGVSMEAIASRVGISAAALYRHYSSKYELFRDAVLNLGQQLVDCT
Mb1998c|M.bovis_AF2122/97 IERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
Rv1963c|M.tuberculosis_H37Rv IERGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
MMAR_2873|M.marinum_M IDRGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
MUL_2880|M.ulcerans_Agy99 IDRGFHSVKLEDIAEAAGVTARALYRHYDNKQALLAEAIRTGQDQYQSAR
MAB_2061c|M.abscessus_ATCC_199 ARQGFHAVGIDDIGAAAGVSGPAVYRHFQNKDAILRELCDAAMTELLAGA
Mflv_1640|M.gilvum_PYR-GCK TDRGYHNVSMDDIASAVGLTGPALYRHFRKKHDILMQVISEQLGAVEAVA
Mvan_3985|M.vanbaalenii_PYR-1 CTRGYEHVGMGDIAEAVAVGPSALYRHFAGKQELLDFVVAGCLG---SAT
MLBr_00815|M.leprae_Br4923 VDHGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLERHMNNLVSSV
*:. . : *. ..: .:*:* * :
MAV_0110|M.avium_104 AFADDLPA---DADPGETLSALTTALIDTTIVNRTAGGLYRWEGRYLRGD
TH_2795|M.thermoresistible__bu DFGDDVDP---AEDPHGLLAALVDALINVTIANRTAGGLYRWEGRYLREP
MSMEG_0815|M.smegmatis_MC2_155 AFADTADAPENSEDAREQLRLLAAALTDTSLANRESGGLYRWEARYLNED
Mb1998c|M.bovis_AF2122/97 RLTEGETE-----PTPRPLNADLEDLIAAAVASRALTVLWQREARYLNED
Rv1963c|M.tuberculosis_H37Rv RLTEGETE-----PTPRPLNADLEDLIAAAVASRALTVLWQREARYLNED
MMAR_2873|M.marinum_M RLTEGEQE-----PTPRPLSVDLPDLIAAAVASRSLTVLWQREARYLNDA
MUL_2880|M.ulcerans_Agy99 RLTEGEQE-----PTPRPLSVDLPDLIAAAVASRSLTVLSQREARYLNDA
MAB_2061c|M.abscessus_ATCC_199 RRATTAGT------PTEVLHALVDLHAAFGARRRGLLAVYAREHRSLSPL
Mflv_1640|M.gilvum_PYR-GCK ARAVDAGP------TDERAEVFLAALADLLLE-REQVLLWKRERRQLAEE
Mvan_3985|M.vanbaalenii_PYR-1 ALVDSVDL--------EDFDLSLLRAAEVSVSNRYTGILLGREARHLAAG
MLBr_00815|M.leprae_Br4923 QQALRTTT-----NNRQRLHAAVQAFFDFIEHDGQGYRLIFENDNITEPR
: : .
MAV_0110|M.avium_104 DQRKLAEQIKVINRRLQRPLIKLRPKLTSRQRWILSAATLSVIGSITDHR
TH_2795|M.thermoresistible__bu DRDILERQIQLVNRRLQRPLRVMRPELGSRQRWTLTASALSAIGSIADHS
MSMEG_0815|M.smegmatis_MC2_155 DQAALNAQMRTVHHRIQRPLQQLRPELISRERWMLSTATLSVIGSVVDHR
Mb1998c|M.bovis_AF2122/97 DRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAWAVSSTLTSLGRHS
Rv1963c|M.tuberculosis_H37Rv DRTAVRRRINAIVAGMRDSVLLEVPDLSPQHSELRAWAVSSTLTSLGRHS
MMAR_2873|M.marinum_M DRIEVRRRINAIVAGMRESVLLEVPGLSPAHSELRAWAVSSTLTSLGRHS
MUL_2880|M.ulcerans_Agy99 DRIEVRRRINAIVAGMRESVLLEVPGLSPAHSELRAWAVSSTLTSLGRHS
MAB_2061c|M.abscessus_ATCC_199 ATRALRRRQHSYESFWVEALVRARGDLDRERAQGLVAAVLSLLNASAYMP
Mflv_1640|M.gilvum_PYR-GCK AQRQCRLKLSDVLRLSSQALGLTSGEKPSGQAELRTWAVLGIYSSVAPIR
Mvan_3985|M.vanbaalenii_PYR-1 AQARLRVAVRHLIGRIAALLAVLRPDLDKDAADLMAWSVVGIVLSPAFSQ
MLBr_00815|M.leprae_Br4923 VAAQVRVATESCIDAVFALISADS-RLDPHRARMVAVGLVGISVDCARYW
: . .
MAV_0110|M.avium_104 SRLGNAEIRATLSDIAAAVLKAE-LPTQRGRGSEPARAPTLTSAAGSYEL
TH_2795|M.thermoresistible__bu APLSVPGIRSFLASVVEDLLAAD-LPTPRRRRAPDPPPPRVTLAAGIYEC
MSMEG_0815|M.smegmatis_MC2_155 GKLPAGQIREVLGEIVESVLAAD-LPELPELGAAAAPATTPVVSAAKYEA
Mb1998c|M.bovis_AF2122/97 LSLPGEELKKLLYQACMAAARTPPVCELPPLPAGDAARDEADVLFSRYET
Rv1963c|M.tuberculosis_H37Rv LSLPGEELKKLLYQACMAAARTPPVCELPPLPAGDAARDEADVLFSRYET
MMAR_2873|M.marinum_M LTLPAEELKERLYQACMAAARTPPVCELEPLGTAAGGRDGQDVLFSRYET
MUL_2880|M.ulcerans_Agy99 LTLPAEELKERLYQACMAAARTPPVCELEPLGTAAGGRDGQDVLFSRYET
MAB_2061c|M.abscessus_ATCC_199 ASLDDATIEAMLAAAAVAALFSRAVTQQVDGAPHRI--------------
Mflv_1640|M.gilvum_PYR-GCK NRVENATAKRLLRAAALNILGCELDTGLPRSATPVTHRRQP---PGRRER
Mvan_3985|M.vanbaalenii_PYR-1 SDLSDREQARLLAQLIGGILTAEAPVGYTIERRRRE--RTGLLPRSRREA
MLBr_00815|M.leprae_Br4923 LDTNRPISKSDAVEGTVQFAWGGLSHVPLTRL------------------
MAV_0110|M.avium_104 LLHESMRLFNERGYRETGMEDIAAAVGIPVASIYQYFPGKAAILAVYYRR
TH_2795|M.thermoresistible__bu VLHESIQMFHERGFRDTGMDDIAAAVGVPTTGIYRYFPGKADILAASLRR
MSMEG_0815|M.smegmatis_MC2_155 LLNESMRLFNKNGYRDTTMEDIAAAVGMPASGIYRYFSGKADILAAGFRR
Mb1998c|M.bovis_AF2122/97 LLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAILDALIRR
Rv1963c|M.tuberculosis_H37Rv LLAAGARLFRAQGYPAVNTSEIGKGAGIAGPGLYRSFSSKQAILDALIRR
MMAR_2873|M.marinum_M LLATGARLFRAQGYPAVSTSEIGKGAGIAGPGLYRSFSSKQAILDALIRR
MUL_2880|M.ulcerans_Agy99 LLATGARLFRAQGYPAVSTSEIGKGAGIAGPGLYRSFSSKQAILDALIRR
MAB_2061c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1640|M.gilvum_PYR-GCK ILSTAGRLFHAQSYHAVGIEEIAAESDTAIATFYQYFNGKGELLHALLNR
Mvan_3985|M.vanbaalenii_PYR-1 LLQEAIRLFAERRYASVGIEDVAASLGMAGPSVYNHFDTKMDLLVTALNR
MLBr_00815|M.leprae_Br4923 --------------------------------------------------
MAV_0110|M.avium_104 AADQLSADLSSILATSSDPEQALARLIEAYVTRSF-ANPELACVYYTERH
TH_2795|M.thermoresistible__bu AVDRTSQDLARITAATADPHTALTQLVRAYLDQFR-ERPALAYVQHTERR
MSMEG_0815|M.smegmatis_MC2_155 AADRLSADMAEILAAGGEPEDVLAALIDDYVTRSF-DRPELEHVYYTERL
Mb1998c|M.bovis_AF2122/97 LDEWRCLECIRALRANQQAAQRLRGLVQGHVRISL-DAPDLVAVSVTELS
Rv1963c|M.tuberculosis_H37Rv LDEWRCLECIRALRANQQAAQRLRGLVQGHVRISL-DAPDLVAVSVTELS
MMAR_2873|M.marinum_M LDEWRSLECIRALRANRQAAQRLRGLVEGHVRISL-DAPDLVAVCVTELN
MUL_2880|M.ulcerans_Agy99 LDEWRSLECIRALRANRQAAQRLRGLVEGHVRISL-DAPDLVAVCATELN
MAB_2061c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1640|M.gilvum_PYR-GCK GAEGLHYVTNHRLASAATAQDALDTVASTLIELALGPHQPILAILAADLV
Mvan_3985|M.vanbaalenii_PYR-1 GAAYLYMQASDGLAASDSAQDALSGLVASYVEFAL-THPALVDLLVTEVR
MLBr_00815|M.leprae_Br4923 --------------------------------------------------
MAV_0110|M.avium_104 NLPETDAVLLYNIQRSTVESWARLAVAARPELTLGRARYAVHAAFALAVD
TH_2795|M.thermoresistible__bu NLPESEARVVERIEQSLVDSWARLVTEQRPELTVATARYAVYCAFALVTD
MSMEG_0815|M.smegmatis_MC2_155 NMTPADQKILRDLQRSAVESWVNVVMPVRPHWSAGQARFAVHAAMALVID
Mb1998c|M.bovis_AF2122/97 HASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGRLLVAAAISFIED
Rv1963c|M.tuberculosis_H37Rv HASVEVRDGYLRNQGDREAVWIDLIGKLVPATSVAQGRLLVAAAISFIED
MMAR_2873|M.marinum_M HASGDVRDGYLRNQADRDTLWIDLIGELVPQTSSVEARLLVAAAISFIED
MUL_2880|M.ulcerans_Agy99 HASGDVRDGYLRNQADRDTLWIDLIGELVPQTSSVEARLLVAAAISFIED
MAB_2061c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1640|M.gilvum_PYR-GCK YLPDAARELIRMSEREYTDEWVAALVGVCPELTPPHARLLARAAIGLITD
Mvan_3985|M.vanbaalenii_PYR-1 NLPEPHRDAALTAQRDYVEEWVHLLRQCHPDRARSAARLQVQAVLSLVNL
MLBr_00815|M.leprae_Br4923 --------------------------------------------------
MAV_0110|M.avium_104 IGRLVYPNTGAPASTTVRRLMEVTVLGRPAAASRDGLRGAGRQRR
TH_2795|M.thermoresistible__bu LGRLTDSHASPSAQAAVQHLMEVVLLGG-----------------
MSMEG_0815|M.smegmatis_MC2_155 LGRLMGYRNSEQARAVVSTMVDLVLLGR------YRLRTALPAR-
Mb1998c|M.bovis_AF2122/97 VARTWHLTRYAGVADEISGLALAILTSGAGNLLRA----------
Rv1963c|M.tuberculosis_H37Rv VARTWHLTRYAGVADEISGLALAILTSGAGNLLRA----------
MMAR_2873|M.marinum_M VARTWHLTRYAAVADEITAIALSILTSRS----------------
MUL_2880|M.ulcerans_Agy99 VARTWHLTRYAAVADEITEIALSILTSRS----------------
MAB_2061c|M.abscessus_ATCC_199 ---------------------------------------------
Mflv_1640|M.gilvum_PYR-GCK ITQIQKMRMRPGIATELHQLVNAVLAA------------------
Mvan_3985|M.vanbaalenii_PYR-1 VARVPHLQATRATAGAVAEMGRHLLAVPPASSA------------
MLBr_00815|M.leprae_Br4923 ---------------------------------------------