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HSGGVLIVVDSPPGTAKARTRDPDRKNRILLAASELIGRRGFHAVSIADIGNAAGITGSGVYRHFESKSA ILVALFDQVIDDLIAEEKRILDETDDLPTALAELIEGQVEFVIGDRQLAQVYHNEINNLPEEDRRRLRRK QRLYLEEWVHLVNELREDLDDTEARVIVHAAIGAIQSPLFHNTGLADDRLRVLLADSARSILSTDRRTP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0343 | - | - | 100% (210) | TetR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_4718 | - | 1e-27 | 35.71% (154) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_0815 | - | 4e-16 | 32.65% (147) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2534 | - | 3e-27 | 35.33% (184) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4599 | - | 1e-46 | 50.56% (180) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv2506 | - | 3e-27 | 35.33% (184) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00815 | - | 2e-08 | 23.17% (164) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4541 | - | 8e-26 | 33.33% (171) | TetR family transcriptional regulator |
| M. marinum M | MMAR_3853 | - | 9e-27 | 34.91% (169) | putative regulatory protein |
| M. avium 104 | MAV_1669 | - | 7e-25 | 34.42% (154) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2795 | - | 1e-16 | 31.29% (147) | PUTATIVE transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_3785 | - | 6e-27 | 34.91% (169) | putative regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_0360 | - | 8e-79 | 74.60% (189) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0343|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0360|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4599|M.gilvum_PYR-GCK --------------------------------------------------
Mb2534|M.bovis_AF2122/97 --------------------------------------------------
Rv2506|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1669|M.avium_104 --------------------------------------------------
MMAR_3853|M.marinum_M --------------------------------------------------
MUL_3785|M.ulcerans_Agy99 --------------------------------------------------
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2795|M.thermoresistible__bu MSAAGSDAHRNGRHRPKNRKALIARASADAFGAQGYHAVSMEEIAARVGI
MLBr_00815|M.leprae_Br4923 --------------------------------------------------
MSMEG_0343|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0360|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4599|M.gilvum_PYR-GCK --------------------------------------------------
Mb2534|M.bovis_AF2122/97 --------------------------------------------------
Rv2506|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1669|M.avium_104 --------------------------------------------------
MMAR_3853|M.marinum_M --------------------------------------------------
MUL_3785|M.ulcerans_Agy99 --------------------------------------------------
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2795|M.thermoresistible__bu SPAALYRHSQGKYDLFRDSVLGLGQLLVDATDFGDDVDPAEDPHGLLAAL
MLBr_00815|M.leprae_Br4923 --------------------------------------------------
MSMEG_0343|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0360|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4599|M.gilvum_PYR-GCK --------------------------------------------------
Mb2534|M.bovis_AF2122/97 --------------------------------------------------
Rv2506|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1669|M.avium_104 --------------------------------------------------
MMAR_3853|M.marinum_M --------------------------------------------------
MUL_3785|M.ulcerans_Agy99 --------------------------------------------------
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2795|M.thermoresistible__bu VDALINVTIANRTAGGLYRWEGRYLREPDRDILERQIQLVNRRLQRPLRV
MLBr_00815|M.leprae_Br4923 --------------------------------------------------
MSMEG_0343|M.smegmatis_MC2_155 -----------------------------------------------MHS
Mvan_0360|M.vanbaalenii_PYR-1 -----------------------------------------------MRT
Mflv_4599|M.gilvum_PYR-GCK -----------------------------------------------MNK
Mb2534|M.bovis_AF2122/97 ------------------------------------------------MT
Rv2506|M.tuberculosis_H37Rv ------------------------------------------------MT
MAV_1669|M.avium_104 --------------------------------------------------
MMAR_3853|M.marinum_M ------------------------------------------------MA
MUL_3785|M.ulcerans_Agy99 ------------------------------------------------MA
MAB_4541|M.abscessus_ATCC_1997 ------------------------------------------------MT
TH_2795|M.thermoresistible__bu MRPELGSRQRWTLTASALSAIGSIADHSAPLSVPGIRSFLASVVEDLLAA
MLBr_00815|M.leprae_Br4923 ----------------------------------MNNLAKAAQRRTVRPI
MSMEG_0343|M.smegmatis_MC2_155 GGVLIVVDSPPGTAKARTRDP-DRKNRILLAASELIGRRGFHAVSIADIG
Mvan_0360|M.vanbaalenii_PYR-1 N--------------ARTRDP-ERKSRIMAAAADLVARKGFHAVSIAEIG
Mflv_4599|M.gilvum_PYR-GCK VVVA-----------GRTRVGGERRERILASATELIAERGYHAVSMADIG
Mb2534|M.bovis_AF2122/97 ASAPDGRPGQPEATNRRSQLKSDRRFQLLAAAERLFAERGFLAVRLEDIG
Rv2506|M.tuberculosis_H37Rv ASAPDGRPGQPEATNRRSQLKSDRRFQLLAAAERLFAERGFLAVRLEDIG
MAV_1669|M.avium_104 -------------------MKSDRRLQLLSAAERLFAERGFLAVRLEDIG
MMAR_3853|M.marinum_M ASAPDEQTATP---NRRSQQKSDRRLQLLSAAERLFAERGFLAVRLEDIG
MUL_3785|M.ulcerans_Agy99 ASAPDEQTATP---NRRSQQKSDRRLQLLSAAERLFAERGFLAVRLEDIG
MAB_4541|M.abscessus_ATCC_1997 NLIPESE--TP---NKRERAKADRRDQLLRAAARLLAMRGYARVRLEDLG
TH_2795|M.thermoresistible__bu DLPTPRRRRAPDPPPPRVTLAAGIYECVLHESIQMFHERGFRDTGMDDIA
MLBr_00815|M.leprae_Br4923 DRGRLSDDIATPNQRSNRLSRDKRRGQLLIVASDVFVDHGYHAAGMDEIA
:: : :. :*: . : ::.
MSMEG_0343|M.smegmatis_MC2_155 NAAGITGSGVYRHFESKSAILVALFDQVIDDLIAEEKRILDETDDLPTAL
Mvan_0360|M.vanbaalenii_PYR-1 AAAGITGSGIYRHFESKSAVLVALFDRVIDELLRDEQEILNTTDDLGQAL
Mflv_4599|M.gilvum_PYR-GCK VASGVVGPAIYRHFNSKSDLLAALFERVVDKLLKRATAIVEQSRDEAEAL
Mb2534|M.bovis_AF2122/97 AAAGVSGPAIYRHFPNKESLLVELLVGVSARLLAGARDVTTRSANLAAAL
Rv2506|M.tuberculosis_H37Rv AAAGVSGPAIYRHFPNKESLLVELLVGVSARLLAGARDVTTRSANLAAAL
MAV_1669|M.avium_104 ASAGVSGPAIYRHFPNKESLLVELLVGISTRLLAGARQVRARSADAAAAL
MMAR_3853|M.marinum_M AAAGISGPAIYRHFPNKESLLVELLVGISSRLLAGARQVTTNSNDAAAAL
MUL_3785|M.ulcerans_Agy99 AAAGISGPAIYRHFPNKESLLVELLVGISSRLLAGARQVTTNSNDAAAAL
MAB_4541|M.abscessus_ATCC_1997 SAVGISGPAIYRHFPNKEALLVDLLTDVSRRLLEGGMTVAAAASSPAEAL
TH_2795|M.thermoresistible__bu AAVGVPTTGIYRYFPGKADILAASLRRAVDRTSQDLARITAATADPHTAL
MLBr_00815|M.leprae_Br4923 DRAGVSKPVLYQHFSSKLELYLAVLERHMNNLVSSVQQALRTTTNNRQRL
*: . :*::* .* : : : . *
MSMEG_0343|M.smegmatis_MC2_155 AELIEGQVEFVIGDRQLAQVYHNEINNLPEEDRRRLRRKQRLYLEEWVHL
Mvan_0360|M.vanbaalenii_PYR-1 DLLIAGQVEFVVADRELAQVYYNEINNLPEEDSRRLRRKQRLYLEEWVHL
Mflv_4599|M.gilvum_PYR-GCK TLLVSDQVALVMDQRELAMVYYREVHNLSDQHQSRLRRKQRLYLEEWVHL
Mb2534|M.bovis_AF2122/97 DGLIEFHLDFALGEADLIRIQDRDLAHLPAVAERQVRKAQRQYVEVWVGV
Rv2506|M.tuberculosis_H37Rv DGLIEFHLDFALGEADLIRIQDRDLAHLPAVAERQVRKAQRQYVEVWVGV
MAV_1669|M.avium_104 DGLIDFHLDFALNEPDLIRIQDRDLAYLPKPAERQVRKAQRQYVEVWVGV
MMAR_3853|M.marinum_M DGLIDFHLDFALGEPDLIRIQDRDLGHLPAAAERQVRKAQRQYVEIWVGV
MUL_3785|M.ulcerans_Agy99 DGLIDFHLDFALGEPDLIRIQDRDLGHLPAAAERQVRKAQRQYVEIWVGV
MAB_4541|M.abscessus_ATCC_1997 DGLIDFHLDFALNESDLIRVQDRDLDSLPENARRQVRQYQRRYVEAWVQV
TH_2795|M.thermoresistible__bu TQLVRAYLDQFRERPALAYVQHTERRNLPESEARVVERIEQSLVDSWARL
MLBr_00815|M.leprae_Br4923 HAAVQAFFDFIEHDGQGYRLIFENDNITEPRVAAQVRVATESCIDAVFAL
: . : : :. . :: :
MSMEG_0343|M.smegmatis_MC2_155 VNELREDLDDTEARVIVHAAIGAIQSPLFHN-TGLAD-------DRLRVL
Mvan_0360|M.vanbaalenii_PYR-1 VNESRVDLTDAEARTVVHAVIGAIQSPLFHN-TGLPE-------DRLRAL
Mflv_4599|M.gilvum_PYR-GCK VGELRPAVDEIELRAMVHGAIGAIQSILHYRGTGLAP-------EQTSAL
Mb2534|M.bovis_AF2122/97 LRELNPGLAEADARLMAHAVFGLLNSTPHSMKAADS---KPARTVRARAV
Rv2506|M.tuberculosis_H37Rv LRELNPGLAEADARLMAHAVFGLLNSTPHSMKAADS---KPARTVRARAV
MAV_1669|M.avium_104 LRELNPELAEADARLTAHAVFGLLNSTPHSMKSQDSGRGKPARAARSRAI
MMAR_3853|M.marinum_M LRQLDPGLAEADARLMAHAAFGLLNSTPHSMKSADT---KSACAPHSRAV
MUL_3785|M.ulcerans_Agy99 LRQLDPGLAEADARLMAHAAFGLLNSTPHSMESADT---KSACAPHSRAV
MAB_4541|M.abscessus_ATCC_1997 LCRSQQGLDESDARIKAHAAFGLMNSTPYSAGRSAP--------SQTRTV
TH_2795|M.thermoresistible__bu VTEQRPELTVATARYAVYCAFALVTDLGRLTDSHASP-------SAQAAV
MLBr_00815|M.leprae_Br4923 IS-ADSRLDPHRARMVAVGLVGISVDCARYWLDTNRP------ISKSDAV
: : * . .. . .:
MSMEG_0343|M.smegmatis_MC2_155 LADSARSILSTDRRTP-------------------
Mvan_0360|M.vanbaalenii_PYR-1 LTDAARAVLGLDR----------------------
Mflv_4599|M.gilvum_PYR-GCK LVAMGHAVLGVPASSHQVRGVNTEPSCPRPGTPQH
Mb2534|M.bovis_AF2122/97 LRAMTVAALSAADRCL-------------------
Rv2506|M.tuberculosis_H37Rv LRAMTVAALSAADRCL-------------------
MAV_1669|M.avium_104 MRAMTVAALAAGNQCP-------------------
MMAR_3853|M.marinum_M MRAMTVAALTVDVGA--------------------
MUL_3785|M.ulcerans_Agy99 MRAMTVAALTVDVGA--------------------
MAB_4541|M.abscessus_ATCC_1997 LRQMVVAALRS------------------------
TH_2795|M.thermoresistible__bu QHLMEVVLLGG------------------------
MLBr_00815|M.leprae_Br4923 EGTVQFAWGGLSHVPLTRL----------------