For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TIATDVLIVGAGPVGLAAAMVLTQQGRDVTVVDGQAEGANTSRAAVVHARTLELLEPYGVVDDLVNRGVH TPAFTIRDRDELLVEVPFGRLPTAYPYTLMISQADTEAFLLKRLEALGGKVIRPATVTSVTQHGTHAMVT FEDGQRIRARYVVGADGMHSTVREAARIPFSGSTYAESFVLADVRLSGGIPTKEVILYFSPAGLVVVAPL PDGIHRIVATVDAQQAQAHPDAAFVQGLLDERGPHASPAAVRDVVWSSRFRVHHRVADTFRANRILLAGD AAHVHSPAGGQGMNLGIEDAVMLAGALSEVLDGAPDTALDDYAADRRRTAQKIVAATGRLTDLATASARK RPLRNRIMRAAGSLPAVRRALAWRLSGLDRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1699 | - | - | 100% (382) | pentachlorophenol 4-monooxygenase |
| M. smegmatis MC2 155 | MSMEG_1499 | - | 8e-48 | 34.90% (384) | oxygenase |
| M. smegmatis MC2 155 | MSMEG_2252 | - | 2e-42 | 32.53% (375) | flavin-type hydroxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1780 | - | 2e-14 | 26.63% (323) | hypothetical protein Mb1780 |
| M. gilvum PYR-GCK | Mflv_5009 | - | 5e-48 | 35.23% (386) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv1751 | - | 2e-14 | 26.63% (323) | hypothetical protein Rv1751 |
| M. leprae Br4923 | MLBr_02276 | - | 6e-08 | 25.08% (323) | putative FAD-linked oxidoreductase |
| M. abscessus ATCC 19977 | MAB_3483 | - | 1e-39 | 33.42% (377) | hypothetical protein MAB_3483 |
| M. marinum M | MMAR_4271 | - | 6e-43 | 32.55% (381) | hypothetical protein MMAR_4271 |
| M. avium 104 | MAV_2736 | - | 3e-42 | 32.63% (380) | hypothetical protein MAV_2736 |
| M. thermoresistible (build 8) | TH_4641 | - | 2e-58 | 38.79% (379) | PUTATIVE oxygenase |
| M. ulcerans Agy99 | MUL_3663 | - | 5e-13 | 27.19% (342) | hypothetical protein MUL_3663 |
| M. vanbaalenii PYR-1 | Mvan_0779 | - | 8e-47 | 35.68% (384) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1780|M.bovis_AF2122/97 MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
Rv1751|M.tuberculosis_H37Rv MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
MUL_3663|M.ulcerans_Agy99 -------------------------------------MPQPS--------
Mflv_5009|M.gilvum_PYR-GCK ----------------------------------------------MPGA
Mvan_0779|M.vanbaalenii_PYR-1 -------------------------------------------------M
TH_4641|M.thermoresistible__bu ----------------------------------------------MARE
MSMEG_1699|M.smegmatis_MC2_155 ------------------------------------------------MT
MMAR_4271|M.marinum_M -------------------------------------------------M
MAV_2736|M.avium_104 ---------------------------------------MRGVRFSERSV
MAB_3483|M.abscessus_ATCC_1997 -------------------------------------------------M
MLBr_02276|M.leprae_Br4923 ----------------------------------------------MRVE
Mb1780|M.bovis_AF2122/97 ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLR-DFRGDTVHPT
Rv1751|M.tuberculosis_H37Rv ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLR-DFRGDTVHPT
MUL_3663|M.ulcerans_Agy99 ETTSVLVAGGGPAGMVLGLLLARAGVDVTVMEKHADFLR-DSRGDTVHAS
Mflv_5009|M.gilvum_PYR-GCK HRSDVVVVGAGPTGLTLACCLRLHGVSVRVLDAAAGPAT-TSRANFLHAR
Mvan_0779|M.vanbaalenii_PYR-1 TDTDVVVVGAGPTGLTLACALRLHGLTVQVVDRAAGPAT-TSRANFLHAR
TH_4641|M.thermoresistible__bu TTTDVVVVGAGPVGLAVACGLLAHGLDVRVIDKAPAPAT-TSRANFLHAR
MSMEG_1699|M.smegmatis_MC2_155 IATDVLIVGAGPVGLAAAMVLTQQGRDVTVVDGQAEGAN-TSRAAVVHAR
MMAR_4271|M.marinum_M ADHAVVVVGAGPTGLMLAGELALAGVDVAVVERRVSQDLVGSRAGGLHSR
MAV_2736|M.avium_104 RGHAVLVAGAGPTGLMLAGELGLAGVDVALVERRADQQLIGSRAGGLHAR
MAB_3483|M.abscessus_ATCC_1997 TEHAVVIAGGGPTGLMLAGELALAGADVAIVERRTTHELDGSRAAGMTSR
MLBr_02276|M.leprae_Br4923 TSADVVVVGAGPAGSAAATWAARAGNDVIVIDSVCFPRD-KACGDGLTPR
: *.**.* . * * ::: . : .
Mb1780|M.bovis_AF2122/97 TMRLLDELGLWERFAALPYSEVRTATLHSNG-RAVTYIDFERLHQPYPYV
Rv1751|M.tuberculosis_H37Rv TMRLLDELGLWERFAALPYSEVRTATLHSNG-RAVTYIDFERLHQPYPYV
MUL_3663|M.ulcerans_Agy99 TLRLLDELGLGSQFAQIPHRLIDTISMKVQG-QPVD-LDLKHLPGAHQHI
Mflv_5009|M.gilvum_PYR-GCK GSEVLDRMGALGTLPQESLRALRITNYLGDRPLATLEFGDPGMRTAAP-P
Mvan_0779|M.vanbaalenii_PYR-1 GSEVLGRIGALGTLPDESLRAMRITNYLGDRPLVTLEFGDPRMRTAAP-P
TH_4641|M.thermoresistible__bu GSEVLDRLGALGGLPERSVRAMQITTHLGGEPVMRMQFGDPGMRTAAP-P
MSMEG_1699|M.smegmatis_MC2_155 TLELLEPYGVVDDLVNRGVHTPAFTIRDRDELLVEVPFG--RLPTAYPYT
MMAR_4271|M.marinum_M TIEVLDQRGIADRFLAQGTATQVAR-------FAAIPLDISDFPTRHNYG
MAV_2736|M.avium_104 TLEILDQRGIVDRFLAEGQVAQVAG-------FAQIRLDISDFPTRHPYG
MAB_3483|M.abscessus_ATCC_1997 TLEVLDQRGILDRFTPQGFSAPVAH-------FSALLLDMTDQPTRHTFG
MLBr_02276|M.leprae_Br4923 AVAELKRLGLDDWLNTRIRHRGLRMSGFGG--EVEVDWPGPSFPSTSS--
* * :
Mb1780|M.bovis_AF2122/97 AMVPQWDLLNLLAEAAQAEPSFTLRMKTEVTGLLR----EGGKVTGVRYQ
Rv1751|M.tuberculosis_H37Rv AMVPQWDLLNLLAEAAQAEPSFTLRMKTEVTGLLR----EGGKVTGVRYQ
MUL_3663|M.ulcerans_Agy99 ALVPQWDFLELLAAAAEAEPTFRLLRSTEVTGVLWGDGPDPGRVVSATYR
Mflv_5009|M.gilvum_PYR-GCK MVVSQAKVEAALRARLADLD-VEPEWGRKVIDVRE-------DADGVVAD
Mvan_0779|M.vanbaalenii_PYR-1 MVISQAKVEASLRSRLADLG-AEPQWGNGLAALHR-------NDDTVVAE
TH_4641|M.thermoresistible__bu MVISQAEVEAALRNRLAELG-GRVELDCPLTGLRQ-------DASTVTAG
MSMEG_1699|M.smegmatis_MC2_155 LMISQADTEAFLLKRLEALG-GKVIRPATVTSVTQ-------HGTHAMVT
MMAR_4271|M.marinum_M LALWQNRIERILAEWVAELR-VRIYRGCEVTDITQ-------DDNGVDLT
MAV_2736|M.avium_104 LALWQNHIERILADWVGELG-VPIYRGHRIATCTQ-------DDTGVDVV
MAB_3483|M.abscessus_ATCC_1997 LALLQYRIERTLSEWVGEHG-VPIYRGREVTGFTS-------SDDAVRVE
MLBr_02276|M.leprae_Br4923 -AVPRLELDDRIRKVAENSG-ARMLLGTKAVSVYHD-----SSRRAASVT
: : : .
Mb1780|M.bovis_AF2122/97 GAEG-PGELRAELTVACDGRWSIARHEAGLKAR--EFPVNFDVWWFKLPR
Rv1751|M.tuberculosis_H37Rv GAEG-PGELRAELTVACDGRWSIARHEAGLKAR--EFPVNFDVWWFKLPR
MUL_3663|M.ulcerans_Agy99 AQSGETKHMHADLTVACDGRGSTVRSALGMATR--SFGAPMDVWWFRLPR
Mflv_5009|M.gilvum_PYR-GCK LADG--ARVRGQWLVGCDGTTSVVRRQTGIEFPGVRLSERFLLADIHLDW
Mvan_0779|M.vanbaalenii_PYR-1 LDDG--TSVEARWLVGCDGTASTTRKLAGIGFPGVKLTERWLLADLHLDW
TH_4641|M.thermoresistible__bu IGGG--GELRGRWLVGCDGTGSSTRKSVGIGYPGARLSERFLLADVYLDW
MSMEG_1699|M.smegmatis_MC2_155 FEDG--QRIRARYVVGADGMHSTVREAARIPFSGSTYAESFVLADVRLSG
MMAR_4271|M.marinum_M LSDG--PPLRADYVVGCDGGRSLVRRAVGIDFPGWDPTTSSLIAEVEVAV
MAV_2736|M.avium_104 ASDG--RTLRGQYLVGCDGGRSVIRKAAGIDFPGWEATTSYLLAEAEMDW
MAB_3483|M.abscessus_ATCC_1997 LSDG--STLRAQYLVGCDGGRSLTRKIAGIDFPGWDPSTSCLVADVQMTE
MLBr_02276|M.leprae_Br4923 LADG--TEVGCRQLIIADGARSPLGRKLGRSWHQKTVYGVAARGYLTTPR
* : : .** *
Mb1780|M.bovis_AF2122/97 EGDAEFSFLPRFSPGKGLGVIPREG--YFQIAYLGPKGTDAQLRERGIEE
Rv1751|M.tuberculosis_H37Rv EGDAEFSFLPRFSPGKGLGVIPREG--YFQIAYLGPKGTDAQLRERGIEE
MUL_3663|M.ulcerans_Agy99 RPDDPTGLAGIFNSGHGGIAIDRGD--YYQIAYIIPKGSDAQLRAQGIEA
Mflv_5009|M.gilvum_PYR-GCK AVDRAGTTGWIHPDGVVGAMPMPSTDGRDDLWRLFV-YDPSLDRKPTDSE
Mvan_0779|M.vanbaalenii_PYR-1 DLDRGGTTGWIHPGGLLGAMPMPDSSGAHDLWRVFA-YDPGHTEKPAESE
TH_4641|M.thermoresistible__bu RLDRSGTTGWIHPDGMVGAMPMPDG-----LWRIIA-YDPGPGD--LDQG
MSMEG_1699|M.smegmatis_MC2_155 GIPTKEVILYFSPAGLVVVAPLPDG-----IHRIVATVDAQQAQAHPDAA
MMAR_4271|M.marinum_M GSESGPNLGEVRHDALGVHGFTRLP----DGGPLRVVVTERQLDAGGEPS
MAV_2736|M.avium_104 RTGQPPQWG-IHHDSLGVHALSETE----PAGGVRVLVTERQLRSAAEPN
MAB_3483|M.abscessus_ATCC_1997 E----PEWGIHRQGAL--HSIFKFE----EDGPVRVLVTEAQLGRREEPT
MLBr_02276|M.leprae_Br4923 SDDLWLTSHLELRSPDGAVLPGYGWIFPLGNGEVNIGVGALSTSKRPADL
:
Mb1780|M.bovis_AF2122/97 FRRDVSELLPEATASVA--ALASTDEVKHLNVKVNRLRRWHIDGLLCIGD
Rv1751|M.tuberculosis_H37Rv FRRDVSELLPEATASVA--ALASMDEVKHLNVKVNRLRRWHIDGLLCIGD
MUL_3663|M.ulcerans_Agy99 LHRALADLMPWLADRVD--ALKSFDDVKLLDVQLNRLRRWYCDGALCIGD
Mflv_5009|M.gilvum_PYR-GCK ILDRISELVPYRTGRR--VKIGDAEWLSMFTVHRRLADTYRRGRVLIAGD
Mvan_0779|M.vanbaalenii_PYR-1 ILERMRQVIPQRSGRR--VHVGDPEWLSVFTVHRRLADRYRQGRILIAGD
TH_4641|M.thermoresistible__bu ALER---LLYERTGHR--VKVTGTVWQSEFRVHRRLADTYRRGRVFIAGD
MSMEG_1699|M.smegmatis_MC2_155 FVQG---LLDERGPHASPAAVRDVVWSSRFRVHHRVADTFRANRILLAGD
MMAR_4271|M.marinum_M LGDLSAALTAVYGTDYG---IHSPTWISRFTDLTRQAATYRQGRVLIAGD
MAV_2736|M.avium_104 LDDLRQALIAVYRTDYG---IHSPRWISRFTDAARQAARYRDRRVLLAGD
MAB_3483|M.abscessus_ATCC_1997 LRDLSEALLSARGTDYG---IHSPTWISRFTDVTRQAATYRKGRVLLAGD
MLBr_02276|M.leprae_Br4923 ALRSLISYYTDLRRHEWGFSGQPRAVSSALLPMGGAVSGVAGPNWMLIGD
. : : **
Mb1780|M.bovis_AF2122/97 AAHAMSPVAGVGINLAVQDAVAAATILAEPLREHRVSSRHLAAVRRRRAF
Rv1751|M.tuberculosis_H37Rv AAHAMSPVAGVGINLAVQDAVAAATILAEPLREHRVSSRHLAAVRRRRAF
MUL_3663|M.ulcerans_Agy99 AAHAMSPVGGVGINLALADAVATARMLAPSLRVGRVSTGQLARVQARRWA
Mflv_5009|M.gilvum_PYR-GCK AAHVHAPFGGQGMLTGIGDAENVGFKLALVVRGLAADDLLDTYEAERRPL
Mvan_0779|M.vanbaalenii_PYR-1 AAHAHAPFGGQGMLTGIGDAENLAFKLALVTRGLAADPFVDTYEAERRPL
TH_4641|M.thermoresistible__bu AAHAHAPFGGQGMLTGLGDAENLAFKLALVIRGYAGPALLDTYEAERRPL
MSMEG_1699|M.smegmatis_MC2_155 AAHVHSPAGGQGMNLGIEDAVMLAGALSEVLDG-APDTALDDYAADRRRT
MMAR_4271|M.marinum_M AAHVHDPVGGQGLNTGVQDAVNLGWKLAQVVNRRSPESLLDTYHAERHPV
MAV_2736|M.avium_104 AAHIHHPVGGQGLNTGVQDAVNLGWKLALVVGGASPPALLDTYHAERHPV
MAB_3483|M.abscessus_ATCC_1997 AAHVHFPIGGQGLNTGMQDAVNLGWKLAQVVNGTSPENLLDTYHAERHPV
MLBr_02276|M.leprae_Br4923 AAACVNPLNGEGIDYGLETGRLAAELLDLRDLSYVWPSLLQQHYGRGFSV
** * * *: .: . . *
Mb1780|M.bovis_AF2122/97 PTAVTQAVQRVLHRRLLGPLLQGRD--PTPPAALLGLVERLPWLSAVPAY
Rv1751|M.tuberculosis_H37Rv PTAVTQAVQRVLHRRLLGPLLQGRD--PTPPAALLGLVERLPWLSAVPAY
MUL_3663|M.ulcerans_Agy99 PTAFLQGIQRAIHAAIVAVAVTGGP--PQPPPVVR-LVSRSVPVRRIMGY
Mflv_5009|M.gilvum_PYR-GCK ATQVLRGTSAITRVNVAGNPIVRFLRDRVAPRVFGLPAVQRWTTYTASQL
Mvan_0779|M.vanbaalenii_PYR-1 ATEVLRGTSAVTRVNIAGNPVGRFLRDRVAPKVFGLAPVQRWTTYTASQL
TH_4641|M.thermoresistible__bu ATEVLRNTSAATKLNIADRGVGRFLRDRVVLPLLALPSVQRRLTYQTSQL
MSMEG_1699|M.smegmatis_MC2_155 AQKIVAATGRLTDLATAS-ARKRPLRNRIMRAAGSLPAVRRALAWRLSGL
MMAR_4271|M.marinum_M AARVLRTTMAQVALRRLDYRKKALS--DTISELLMMDEPRKRFAAMMSGL
MAV_2736|M.avium_104 GERVLRNAIAQMALLRPDERTRALR--DLVTELLGMDEPRKRFAAMISGL
MAB_3483|M.abscessus_ATCC_1997 AARVLHNTMAQTALIRPGERVDALR--DIMSDLLTLDMPRRRIAAMMSGL
MLBr_02276|M.leprae_Br4923 ARRLALLLTFKRCLPAIGPSAMRSTSLITIAVRVMANLVTDDDADWVARV
.
Mb1780|M.bovis_AF2122/97 FVGVG-----------VRPEHAPAFARRGPGNRKGP--------------
Rv1751|M.tuberculosis_H37Rv FVGVG-----------VRPEHAPAFARRGPGNRKGP--------------
MUL_3663|M.ulcerans_Agy99 LVAIG-----------PLPEHAPKYPRRAR--------------------
Mflv_5009|M.gilvum_PYR-GCK WVSYRNGPLGGRGS---KPRPGDRIDDAPCSRPDGTATRLHGELGGRWAL
Mvan_0779|M.vanbaalenii_PYR-1 WVSYRKGPLGGRGP---KPRAGDRIPDVACVRPDGTPSLLHRELSGRWAL
TH_4641|M.thermoresistible__bu WVTYRGGPLAPRTVSMTTPRPGDRVPDQRCVRDDGHISRLYEQLGGRWAV
MSMEG_1699|M.smegmatis_MC2_155 DRR-----------------------------------------------
MMAR_4271|M.marinum_M DIRYHLGGG--------HPLLGRRMPDLDLTTADGPRRVFTHLHAARPVL
MAV_2736|M.avium_104 DVRYDLGPG--------HPLLGRRMPDLDLVTADGASRVFALLRNARPVL
MAB_3483|M.abscessus_ATCC_1997 DIHYDLGPG--------HPLLGRRMPDLEVRTAQGPRCVFTLLREGRGVL
MLBr_02276|M.leprae_Br4923 WRSGG-----------WASWLVDRRPPFS---------------------
Mb1780|M.bovis_AF2122/97 --------------------------------------------------
Rv1751|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3663|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5009|M.gilvum_PYR-GCK LLPRG--VPAVG-----AAAVRGPAGYLADHVVTLH---HDRDDVMLVRP
Mvan_0779|M.vanbaalenii_PYR-1 LAPPD--APAGC-----ADVAR---RHLGDFVEPLT---FDGDEAMLIRP
TH_4641|M.thermoresistible__bu LEPGSGRHHREG-----PGLLGTAHTFLGEYVVGLRGAEMRGCDAFLVRP
MSMEG_1699|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_4271|M.marinum_M LNLAEPGRFDIAGWRHRVLLIDAKYV---GVWELPVLGAIAAPAAALIRP
MAV_2736|M.avium_104 LNFAGAGRRSVAGWADRVRVVDAKCV---ADWELPVLGRVSAPPAVLIRP
MAB_3483|M.abscessus_ATCC_1997 LNLGTP-ITGASGWSHRVDVVEAEYLDAEGTFELPVIGMVEAPHAVLIRP
MLBr_02276|M.leprae_Br4923 --------------------------------------------------
Mb1780|M.bovis_AF2122/97 ---------------------------------------
Rv1751|M.tuberculosis_H37Rv ---------------------------------------
MUL_3663|M.ulcerans_Agy99 ---------------------------------------
Mflv_5009|M.gilvum_PYR-GCK DAHLAWRGAHDDPTGLDRWLATALHPGGTQ---------
Mvan_0779|M.vanbaalenii_PYR-1 DGHLAWRGDAGDADGVNLWLTRALTTGNAR---------
TH_4641|M.thermoresistible__bu DGHLAWRG--RDATDLADWLKSALTVGRVR---------
MSMEG_1699|M.smegmatis_MC2_155 ---------------------------------------
MMAR_4271|M.marinum_M DGYVAWVGDDLTDRGLFDALTAWFGRPAVPSPRLRASAP
MAV_2736|M.avium_104 DGHVAWAGD-PNDPGLHDALTTWCGPPAAGG--------
MAB_3483|M.abscessus_ATCC_1997 DGYVAWVGN-GTTAGLNGALQRWFGPPRYSGGGS-----
MLBr_02276|M.leprae_Br4923 ---------------------------------------