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LRGRTTELAALSKLVASSRAGHSAVVVLRGEAGIGKTALIDHLSDAVASEFRVLRTAGVESDMELPFAGV HRLIAVLWGEPVEELPVPQRQALATAFGQASGPAPDRFLVGLAVLGLIATASEDRPVLCVVDDAQWLDQV SAQTLSFVARRLLAERVMIVFACREKITELRGFPELVISGLSVPDARELLDGAVLGRIDPRVRDRIVAET RGNPLALLEILRDLGPADLAGGYHRPDAYPVEESIEARYLQRILTLGDDARLLLTLAAAEPVGDPALLSR AAESLGIAASALASLRSARLINIDTRVRFGHPLVRSVAYADADADQRHRVHAALAKSIDPSEDPDRRAWH RAFASTGPDESVADELEQAATRAHQRGGIAAAAAFLTQAFELTRDPVRRGQRALEAAHAKRRAADFNAAT ELVTAASLSPLDDLDEARRLHLETQLAFHRRRTDPSGPPLADHAATMSKAAARLRPLDPAEADQAYLEAI CGLIYAGRLADSTALEQMASAILHLRDDGRGRRPVGLLARGLARRVSPDIAGGIAAIRTAVASVTEHGWQ WEAFPLALEVSLHETWDDEAWERLSEVAVHLATETAALQILPTALVSRAGALVMAGDLAGARLLIAEADD ISSAIGHAPLRYHKLTLASWAGNDGETTAMAAAALRDGLQRGEGRVIALAAYANGVLNNGLGRYDVAMEA LQPACEYDDLGIVGWNLSELVECAVRAGRDDLAADALNKLKLRIGAASTPWGLGIAARSAALLAADDAAE PLYLDAIGHLGRSRVKVQLARAHLLYGEWLRRMNRRNDARHHLRLAHEMLQGFGVNAFADRAARELIPLG EKTVKRKRTGTALTPQETQVAQLAAAGLTNTEIGSQLFISAHTVEWHLSNVYAKLAIKSRRQLRAMKLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4053 | - | - | 100% (910) | transcriptional regulatory protein |
| M. smegmatis MC2 155 | MSMEG_0321 | - | 0.0 | 49.84% (925) | transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_3290 | - | 0.0 | 43.97% (912) | regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2515c | - | 6e-11 | 26.26% (655) | LuxR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1156 | - | 4e-60 | 28.18% (958) | regulatory protein, LuxR |
| M. tuberculosis H37Rv | Rv2488c | - | 6e-11 | 26.26% (655) | LuxR family transcriptional regulator |
| M. leprae Br4923 | MLBr_02341 | - | 1e-12 | 25.93% (378) | putative regulatory protein |
| M. abscessus ATCC 19977 | MAB_3361 | - | 0.0 | 48.59% (889) | LuxR family transcriptional regulator |
| M. marinum M | MMAR_0085 | - | 1e-172 | 41.57% (919) | transcriptional regulatory protein |
| M. avium 104 | MAV_2364 | - | 2e-15 | 24.04% (990) | TPR repeat-containing protein |
| M. thermoresistible (build 8) | TH_3225 | - | 0.0 | 50.11% (920) | PUTATIVE regulatory protein, LuxR |
| M. ulcerans Agy99 | MUL_2555 | - | 8e-21 | 27.13% (586) | hypothetical protein MUL_2555 |
| M. vanbaalenii PYR-1 | Mvan_5002 | - | 0.0 | 50.92% (919) | regulatory protein, LuxR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2515c|M.bovis_AF2122/97 ----MDRRPRDFEQSRRRCRCNALRAGSMLASMSKIHPGVDVVPVDWSAD
Rv2488c|M.tuberculosis_H37Rv ----MDRRPRDFEQSRRRCRCNALRAGSMLASMSKIHPGVDVVPVDWSAD
TH_3225|M.thermoresistible__bu ----MSSRD-----GDVVLHGRAAEIATLRDVMSTARAGSSRVLVLHGEA
Mvan_5002|M.vanbaalenii_PYR-1 MDTRLDTRHPAGHRARPPLRGRGHECRELQNLIAAVRTGASRSLVLRGEA
MAB_3361|M.abscessus_ATCC_1997 --------------------------------------------MLRGQA
MSMEG_4053|M.smegmatis_MC2_155 -----------------MLRGRTTELAALSKLVASSRAGHSAVVVLRGEA
MMAR_0085|M.marinum_M -------------MPTVTLVGRHREQQQLQQLLDAARRGESGVLVLRGDA
Mflv_1156|M.gilvum_PYR-GCK -------------------------MKAVDDFLAGLQQLQPAGLLIEGEA
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
MAV_2364|M.avium_104 --------------------------MEFRRSLAALNNGEFHGVALVGDG
MLBr_02341|M.leprae_Br4923 ----------------------------MTTALVCVACGAELRSIAKFCD
Mb2515c|M.bovis_AF2122/97 GVSELVPTG-TVTLLLADIEGATHLPG-SQLDTT-AIAKLDRTLTELVRE
Rv2488c|M.tuberculosis_H37Rv GVSELVPTG-TVTLLLADIEGATHLPG-SQLDTT-AIAKLDRTLTELVRE
TH_3225|M.thermoresistible__bu GVGKTALLG-QLLG-DAAGMRCVQVAG-VESDMELAYAGLHQLCAPLL-D
Mvan_5002|M.vanbaalenii_PYR-1 GIGKTALLD-HVVA-QAEGFRTTYVAG-VESDMELAFAGLHQLCAPLL-T
MAB_3361|M.abscessus_ATCC_1997 GVGKTALLR-YVLG-KASGQLIAQASG-IQSEMELAFAGLQQFCAPLT-K
MSMEG_4053|M.smegmatis_MC2_155 GIGKTALID-HLSDAVASEFRVLRTAG-VESDMELPFAGVHRLIAVLWGE
MMAR_0085|M.marinum_M GIGKTTLLT-DLVD-NAPDLRVLRVRG-AEMEMELTYSGVQQLCGPLM-S
Mflv_1156|M.gilvum_PYR-GCK GIGKTTMLAGVVDAARQAGFRVLSAHG-DQSGSGLAHAAIADLFAGVQTD
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
MAV_2364|M.avium_104 GVGKSTLARMLAKTVESAGRTVRFALG-TQTGWAVPLGAFSR--------
MLBr_02341|M.leprae_Br4923 ECGSPVVEAETPAEYKQVTVLFADVVGSMDIAAAVGLERLREIMT-----
Mb2515c|M.bovis_AF2122/97 HRGVCPVEQGEGDSFLVAFARASDAVACALGLQRAPLAPIRLRIGMHTGE
Rv2488c|M.tuberculosis_H37Rv HRGVCPVEQGEGDSFLVAFARASDAVACALGLQRAPLAPIRLRIGMHTGE
TH_3225|M.thermoresistible__bu RLDDLPSPQ-------------RDVLNVAFGRGAG-PAPGRFLVGLAVLN
Mvan_5002|M.vanbaalenii_PYR-1 HLDELPDPQ-------------RDALTVAFGQGAG-ATPDRFLVGLAVLS
MAB_3361|M.abscessus_ATCC_1997 YSGAIPDPQ-------------REALTIAFGTRSG-PPPDRFLIGLAVLS
MSMEG_4053|M.smegmatis_MC2_155 PVEELPVPQ-------------RQALATAFGQASG-PAPDRFLVGLAVLG
MMAR_0085|M.marinum_M LIGQLPEPQ-------------LDALEIALGRKRG-RAPDRLLLGLAVLT
Mflv_1156|M.gilvum_PYR-GCK ILDGLPELQRR-----------AADGVLRRGDGTGGPTDERVIAAALLGA
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
MAV_2364|M.avium_104 ------------------------AVSLGVG------HEPAIMLAAAHNT
MLBr_02341|M.leprae_Br4923 -----------------------ELVSRAAGVIERYGGTVDKFTGDGIMA
Mb2515c|M.bovis_AF2122/97 VSSPDEGNCVGPTIDRTARLRELAHGGQTVLSGTTSDLVADLLPKDAWLN
Rv2488c|M.tuberculosis_H37Rv VSSPDEGNCVGPTIDRTARLRELAHGGQTVLSGTTSDLVADLLPKDAWLN
TH_3225|M.thermoresistible__bu LLAAAG----------------------------ADQPLLCVIDDAQWLD
Mvan_5002|M.vanbaalenii_PYR-1 LMAAAS----------------------------TGGPLLCVIDDAQWLD
MAB_3361|M.abscessus_ATCC_1997 LLAAAA----------------------------EHQPVLCVIDDAQWLD
MSMEG_4053|M.smegmatis_MC2_155 LIATAS----------------------------EDRPVLCVVDDAQWLD
MMAR_0085|M.marinum_M LVGEAS----------------------------RASPILCVVDDAQWVD
Mflv_1156|M.gilvum_PYR-GCK VHGSAT-----------------------------RTPVLVAVDDVQWLD
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
MAV_2364|M.avium_104 LGQDKN--------------------------------LVVVVDEAQLLD
MLBr_02341|M.leprae_Br4923 IFGAPT-----------------------------------ALEDHALRA
Mb2515c|M.bovis_AF2122/97 DLGTYRLDDLPRPERVVQLCHPDLHNAFPPLRTRKVVGAHCLPAQLTRLV
Rv2488c|M.tuberculosis_H37Rv DLGTYRLDDLPRPERVVQLCHPDLHNAFPPLRTRKVVGAHCLPAQLTRLV
TH_3225|M.thermoresistible__bu RVSLQTLGFVARR-----------------LMAEPVAMVFALRDDIHEAL
Mvan_5002|M.vanbaalenii_PYR-1 QVSVQTLAFVARR-----------------LLAEPIAMVFAARDTGAEAL
MAB_3361|M.abscessus_ATCC_1997 RVSLQTLAFVTRR-----------------LGSEPVAMLFAVRDGTDSEL
MSMEG_4053|M.smegmatis_MC2_155 QVSAQTLSFVARR-----------------LLAERVMIVFACREKIT-EL
MMAR_0085|M.marinum_M SASVQALAFVARR-----------------IHVDPVAMVFATRDRGPDAL
Mflv_1156|M.gilvum_PYR-GCK PSSVAVLAFVARR------------------VKGRVGFVVAERPGVGPGL
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
MAV_2364|M.avium_104 PLSATLVNQLAAG------------------RSARLIVTIRSGEPVLDAV
MLBr_02341|M.leprae_Br4923 CLAALGVQEKARR-------------------------------------
Mb2515c|M.bovis_AF2122/97 GRVDEVAQVRGLLDVKRWVTLTGVGGVGKTRLATQVASAVADGYPDGVWY
Rv2488c|M.tuberculosis_H37Rv GRVDEVAQVRGLLDVKRWVTLTGVGGVGKTRLATQVASAVADGYPDGVWY
TH_3225|M.thermoresistible__bu VGVPALAVP----------------GLADADARTLLEHMFPGAIDANVRD
Mvan_5002|M.vanbaalenii_PYR-1 SGLPELAVP----------------GLSDGEARDLLDSVVVGRLDDRVRD
MAB_3361|M.abscessus_ATCC_1997 AGLPELTVH----------------GLRAADAGTLLDSVIPGLLDERVRD
MSMEG_4053|M.smegmatis_MC2_155 RGFPELVIS----------------GLSVPDARELLDGAVLGRIDPRVRD
MMAR_0085|M.marinum_M TGHCELSLQ----------------GLEDHDARLVLSTAIPGRLNDSVAE
Mflv_1156|M.gilvum_PYR-GCK PAATWLQVGTG------ALTRLPVAPMSLGALHTMLSSRLGRRFSRPQIV
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
MAV_2364|M.avium_104 TALLKERLLLT----------VHVDPFTREQTELLAGAVLGGPVDTRLVD
MLBr_02341|M.leprae_Br4923 ---------------------------LAAEVGDRDGVDLQLRVGLNSGQ
Mb2515c|M.bovis_AF2122/97 VNLAPITDPALVPIAAARVLGLPDQPGRSTVDTIVRRIGDRRMLVVLDNC
Rv2488c|M.tuberculosis_H37Rv VNLAPITDPALVPIAAARVLGLPDQPGRSTVDTIVRRIGDRRMLVVLDNC
TH_3225|M.thermoresistible__bu RLVAESRGNPLALLEVPRTYAVGELAG-----------------------
Mvan_5002|M.vanbaalenii_PYR-1 RIIAETRGNPLALLDLPHNHVGTELPG-----------------------
MAB_3361|M.abscessus_ATCC_1997 RIVAETQGNPLALLELPRDMTAEELAG-----------------------
MSMEG_4053|M.smegmatis_MC2_155 RIVAETRGNPLALLEILRDLGPADLAG-----------------------
MMAR_0085|M.marinum_M TVLAEANGNPLALLELHNALIRGELAG-----------------------
Mflv_1156|M.gilvum_PYR-GCK RIAEVSGGNPLYALELARVADG----------------------------
MUL_2555|M.ulcerans_Agy99 --------------------------------------------------
MAV_2364|M.avium_104 ELFERSAGNLLLLRGFLTAGVESGALVHT---------------------
MLBr_02341|M.leprae_Br4923 VIVGEIGSSALGYTAVG---------------------------------
Mb2515c|M.bovis_AF2122/97 EHLLDGCAALIVALLGACPALRVLATSREPIAVAGEQIWRVPPLGHGEAI
Rv2488c|M.tuberculosis_H37Rv EHLLDGCAALIVALLGACPALRVLATSREPIAVAGEQIWRVPPLGHGEAI
TH_3225|M.thermoresistible__bu -------------------GFVSPGAGSAPSRIEENYVHRIRALPAQTRR
Mvan_5002|M.vanbaalenii_PYR-1 -------------------SAATPGSRPLARRLEQSYARRIKALPPQTQL
MAB_3361|M.abscessus_ATCC_1997 -------------------GFGWPDGGRLAGQIEQTFLRRVQQLPAHTQT
MSMEG_4053|M.smegmatis_MC2_155 -------------------GYHRPDAYPVEESIEARYLQRILTLGDDARL
MMAR_0085|M.marinum_M -------------------GYGLANATRTETQIERTFVSRLRALPSETKT
Mflv_1156|M.gilvum_PYR-GCK --------------------AGSRPGQRLPESLSELVRLRVDGLAEDVRD
MUL_2555|M.ulcerans_Agy99 -------------------------------------------MPALSAN
MAV_2364|M.avium_104 -----------------EQGWQLQGPLRGDRELHDALEYRLQSLSSEERE
MLBr_02341|M.leprae_Br4923 --------------------------------VQVGMAQRMESVAPPGVV
:
Mb2515c|M.bovis_AF2122/97 ELFTDRAREARPELEITADNLALVTEICHRLDGIPLAIELAASRVRALAL
Rv2488c|M.tuberculosis_H37Rv ELFTDRAREARPELEITADNLALVTEICHRLDGIPLAIELAASRVRALAL
TH_3225|M.thermoresistible__bu LLLIAAAEPIG--------DSALFLRAAALMG-IAVDALAPAEAARVIQF
Mvan_5002|M.vanbaalenii_PYR-1 LLLAAAAEPVG--------DAAVLIRAAAQLG-IAVDMLTPAEAAGVIEL
MAB_3361|M.abscessus_ATCC_1997 LLLAAATDPLG--------DVTLLARAAQQLG-IPMHAIAPAEAADLVEL
MSMEG_4053|M.smegmatis_MC2_155 LLTLAAAEPVG--------DPALLSRAAESLG-IAASALASLRSARLINI
MMAR_0085|M.marinum_M FLLVAAAESTA--------RPEWLWAAAHRLG-IGPEAAAPAEAAGLIAA
Mflv_1156|M.gilvum_PYR-GCK VLLVAASATSP--------TVDLLAKAVGVTPAAVTGLVEAAEVEGIVVI
MUL_2555|M.ulcerans_Agy99 LVASIDRHPER-----------ITLRCDDLQSVFAELGAGPGDRVAALPG
MAV_2364|M.avium_104 VVEVLATAELLEWEILRDICDADAMASLERRGLIQLVTDGSHTLVQLNHP
MLBr_02341|M.leprae_Br4923 MLSES------------------TARLVEQTAVLGAPQTVRIKGAEDAVP
:
Mb2515c|M.bovis_AF2122/97 T-EIVDSLHDRFRLLTGGSRIAVRRQQTMRASVDWSHALLTGPEQVLFRR
Rv2488c|M.tuberculosis_H37Rv T-EIVDSLHDRFRLLTGGSRIAVRRQQTMRASVDWSHALLTGPEQVLFRR
TH_3225|M.thermoresistible__bu G-PRMRFFHPLMRSAAYRAADPRDRRAVHRALAEATDPGADPDRRAWHAA
Mvan_5002|M.vanbaalenii_PYR-1 G-TRVRFRHPLVRSAAYQAADLADRRTVHRALAEATDSATDPDRRAWHAA
MAB_3361|M.abscessus_ATCC_1997 S-TRVRFRHPLVRSAVYISANPLERRRIHGVLAGATDPGADPDRRAWHRA
MSMEG_4053|M.smegmatis_MC2_155 D-TRVRFGHPLVRSVAYADADADQRHRVHAALAKSIDPSEDPDRRAWHRA
MMAR_0085|M.marinum_M Q-GSVRFRHPLIRAAVYHSSSAAERRRVHAALAASIAGPDDDDHRVWHRA
Mflv_1156|M.gilvum_PYR-GCK DGNRIRFTHPVLANGIYAGADPQRRREVHRRLADLKT---DPELRARHLA
MUL_2555|M.ulcerans_Agy99 DRTRRRVCGPACELSGGRFRPSAR-----------------PQSCPGLTE
MAV_2364|M.avium_104 MLGEAATRHAGVVRSRQLNGILAKTLRKHLRAAGRRSQISDPRGRIQLAQ
MLBr_02341|M.leprae_Br4923 ARRLLRVAEPRQPTWFSESTLVGREWELATLAAMLDRSIGGRGSVVGLVG
Mb2515c|M.bovis_AF2122/97 LAVFPSGFDLDGAQAAAAGGDVQRYEVVDLLSLLADKSLVVTDDSDGRTR
Rv2488c|M.tuberculosis_H37Rv LAVFPSGFDLDGAQAAAAGGDVQRYEVVDLLSLLADKSLVVTDDSDGRTR
TH_3225|M.thermoresistible__bu NGVTGTDDAVAAELEKSAARAQQRGGIAATATFLERAVVLTADPGL----
Mvan_5002|M.vanbaalenii_PYR-1 NAATGPDDAVAAELEASAARAQARGGVAAAAAFLERAAALTSDPAL----
MAB_3361|M.abscessus_ATCC_1997 HAAAGTDEAIAWELEQSAGRAQAKGGVLAAAAFLQRATELTADPAA----
MSMEG_4053|M.smegmatis_MC2_155 FASTGPDESVADELEQAATRAHQRGGIAAAAAFLTQAFELTRDPVR----
MMAR_0085|M.marinum_M HAAEAPDAQTADDLERSAERARARGGLSAAASFLEHATKLTPDPFV----
Mflv_1156|M.gilvum_PYR-GCK LASTVADETTLTTLDAAADAARARGAPAAAAELLEWAMQLGGDSVS----
MUL_2555|M.ulcerans_Agy99 AASPGRSRGPLHLARCAAELTIRRGDACQAIELLRRAGELSDRPRR----
MAV_2364|M.avium_104 FIMRSDLEPDLDVVIKAAADAMAMSNVVLGEQLATFAVDRGGGLAA----
MLBr_02341|M.leprae_Br4923 PAGIGKTRLVAEAVQLAKGLEVEVFSVFCESHATDVAFDVVAQLVR----
:
Mb2515c|M.bovis_AF2122/97 YRLLETVRQYALEKLRESGDADAVRARHRDHYAAVAAGLDAPSVAGHERR
Rv2488c|M.tuberculosis_H37Rv YRLLETVRQYALEKLRESGDADAVRARHRDHYAAVAAGLDAPSVAGHERR
TH_3225|M.thermoresistible__bu -----------------RGRRALAAAQAKRDAADSAAAHDLLAIAERAPL
Mvan_5002|M.vanbaalenii_PYR-1 -----------------RGARALAAAQAKRDAAAPAEAQELLSTAELGRL
MAB_3361|M.abscessus_ATCC_1997 -----------------RGRRALAAAQSKYDAAAFDAARELLGVADMTPL
MSMEG_4053|M.smegmatis_MC2_155 -----------------RGQRALEAAHAKRRAADFNAATELVTAASLSPL
MMAR_0085|M.marinum_M -----------------RASRALDAAMTSLEAGMPDSATRLVASAAAAAD
Mflv_1156|M.gilvum_PYR-GCK --------------------RRIRAAEHHVVAGDMRRAATLLEQALVDLR
MUL_2555|M.ulcerans_Agy99 -----------------REQLLASAAFVALQAAQLDEAERLLADAGLGGG
MAV_2364|M.avium_104 ---------------------ALVLAEAVSWQGRGEEADSILLGADVDDA
MLBr_02341|M.leprae_Br4923 ---------------------AVAQISGLDDRSARARVREQIPDADTQDL
. *
Mb2515c|M.bovis_AF2122/97 LNQAELEIDNLRAAFAFSRENGDTGHALLLASCLQPLWRARGRLQEGLAW
Rv2488c|M.tuberculosis_H37Rv LNQAELEIDNLRAAFAFSRENGDTGHALLLASCLQPLWRARGRLQEGLAW
TH_3225|M.thermoresistible__bu SALEWARAVHLRAQLEFARSRAGDAGGPPVGQTAAALLTAAQLLQD----
Mvan_5002|M.vanbaalenii_PYR-1 SELQQAQAARLRAQMEFTRRRGGDTGARPLDETASQLLTAAASFEQ----
MAB_3361|M.abscessus_ATCC_1997 DPLARARATRLRAKIAFAESRVGAFGSVTVSEAAIGLVEAARCLEN----
MSMEG_4053|M.smegmatis_MC2_155 DDLDEARRLHLETQLAFHRRRTDPSG-PPLADHAATMSKAAARLRP----
MMAR_0085|M.marinum_M DELIAARCELIRAKIAFAASRG--------SDAPPLLLAAAQRMQR----
Mflv_1156|M.gilvum_PYR-GCK PGVLCAIALNLLAGVRMVEDDY--------IRAVELLERARADADN----
MUL_2555|M.ulcerans_Agy99 ASASALLISSFISLYRYG-------------DVTATHRRLVERLQS----
MAV_2364|M.avium_104 DEWLIARWGCLRAANLAWGCGDAEG-------ATRVLAEVKQRLAT----
MLBr_02341|M.leprae_Br4923 LLLDDLLG----------------------------IADPAVELPR----
Mb2515c|M.bovis_AF2122/97 FAAALADHDAHPAGADPGLYARALA--DRALIDAVAGITDRLDDAQKALA
Rv2488c|M.tuberculosis_H37Rv FAAALADHDAHPAGADPGLYARALA--DRALIDAVAGITDRLDDAQKALA
TH_3225|M.thermoresistible__bu -VDAPAARESYLEAFAALMYAGRLA--PSGALLEAADAVQAAFARAPEGS
Mvan_5002|M.vanbaalenii_PYR-1 -LDGYVSREAYLEALAAAMFAGRLG--DPGAVPRIAAAASAALDRLPESA
MAB_3361|M.abscessus_ATCC_1997 -LDDNLARETYLDAVGAAMYGGRLC--PRGGAVEVAEPARLAPAGAQP-A
MSMEG_4053|M.smegmatis_MC2_155 -LDPAEADQAYLEAICGLIYAGRLA--DSTALEQMASAILHLRDDGRG-R
MMAR_0085|M.marinum_M -LDPSESRKAYLGAVLASILVGRMATDQHNSSPSVAKAASNAPAAPHP-P
Mflv_1156|M.gilvum_PYR-GCK --DAVLVTTLLSLGFCLGMTG------SFTAQLATVREAVAVAERAGVPA
MUL_2555|M.ulcerans_Agy99 --ADDLDGETLTRMVNLLLAVSMFA-----ADPALWQITDGLVDSLADRL
MAV_2364|M.avium_104 ---EGSLQLIDALDVSIGFFRGDIAR-TIELGPRLCEPDVVPMATVWAAV
MLBr_02341|M.leprae_Br4923 -----LDPDARRRRLTALINVAQLA---------LSRPAVFVVEDVHWID
:
Mb2515c|M.bovis_AF2122/97 IARDIEDPALLARALTACGGVAAYNADLARPWLAEAVGLARAVGDKWRLA
Rv2488c|M.tuberculosis_H37Rv IARDIEDPALLARALTACGGVAAYNADLARPWLAEAVGLARAVGDKWRLA
TH_3225|M.thermoresistible__bu RAVDAFCQGMTQRIVGGISAAAAPLRVALTAMCELARSRPAEV--VHWLV
Mvan_5002|M.vanbaalenii_PYR-1 RPVDALLRGIVARITGGVSAGAAPLRLAMDLMQEQARNNDHRV--ARWMV
MAB_3361|M.abscessus_ATCC_1997 RPSDLLLDGLARRITHGAAASAQTLGEALTLIRCEADRPAN----TSWME
MSMEG_4053|M.smegmatis_MC2_155 RPVGLLARGLARRVSPDIAGGIAAIRTAVASVTEHG-----------WQW
MMAR_0085|M.marinum_M RALDVLLDGLVIRLTEGYVAAAPRLRSAIREYLRERD--------IGVAE
Mflv_1156|M.gilvum_PYR-GCK LTSRALAMWVHVSFQAGNGLDSAALLRAVDLEDPEDN---------TPIP
MUL_2555|M.ulcerans_Agy99 GELSVIYRDAWADAARRGRTVTQRLKEQLDRLAELEP------------W
MAV_2364|M.avium_104 ATCGALTAVGRFSEVGRIAAAGVRATAQCRAG-----------------A
MLBr_02341|M.leprae_Br4923 EVSDSMLADFLAVIPQTRSMALVTYRPEYHGALRHVVG------------
Mb2515c|M.bovis_AF2122/97 EVLAWQAYVGFAGEGDPGATRAAGEEARSLADEIGDAFLSRSCRWALAAA
Rv2488c|M.tuberculosis_H37Rv EVLAWQAYVGFAGEGDPGATRAAGEEARSLADEIGDAFLSRSCRWALAAA
TH_3225|M.thermoresistible__bu PAFPVLQESAGHELWDENLVDALSEAVVRQARDAGALAGLPQALVYRAGV
Mvan_5002|M.vanbaalenii_PYR-1 PAFPIMQETAALELWDETVVHHLASVVVRRARDAGALEALPQVLAYRAGA
MAB_3361|M.abscessus_ATCC_1997 QAFPIALESATHEVWDDDMWHHLATRAVHIAREVGALSLLPAALIYRAGM
MSMEG_4053|M.smegmatis_MC2_155 EAFPLALEVSLHETWDDEAWERLSEVAVHLATETAALQILPTALVSRAGA
MMAR_0085|M.marinum_M PGWHDLTARVCLDLFDQDAYNFLAARQVEDLRAAGALTMLPVALVTFAGV
Mflv_1156|M.gilvum_PYR-GCK FRASAARGLSLALTGRLAEADGQLAAVAQRSAQRGAEQDVMAVLGYRTLV
MUL_2555|M.ulcerans_Agy99 DVMRVALAGYYVDLIDD--FRSVLVPLADREIEGGAATIALATLALVAAY
MAV_2364|M.avium_104 QRFAIGLAEVMAATAAGDYPAAERIHKRYAALATGLPAAEAMVDAMLGVL
MLBr_02341|M.leprae_Br4923 ---AQIIAVAPLSDVETSTLVAELLGLDQSVTQIGELITERAAGNPFFAQ
.
Mb2515c|M.bovis_AF2122/97 NLWQGNLEAAVGLSREVIGESDAAHDMVSSCAGQACLAHALAHRGDTEAA
Rv2488c|M.tuberculosis_H37Rv NLWQGNLEAAVGLSREVIGESDAAHDMVSSCAGQACLAHALAHRGDTEAA
TH_3225|M.thermoresistible__bu HLLFGEFGLADTLLTEAESITAATDHRGPVRYHRLIIAAWRGDAVEAARL
Mvan_5002|M.vanbaalenii_PYR-1 HLLAGELSSAATLLEEAASITAATNNYTPVRYQTLTLAAWRGEPADAEAV
MAB_3361|M.abscessus_ATCC_1997 HVHAGELDAAAELVQEADAISAATG-HAPIRYHSLILAAWRGSEPTAIRL
MSMEG_4053|M.smegmatis_MC2_155 LVMAGDLAGARLLIAEADDISSAIG-HAPLRYHKLTLASWAGNDGETTAM
MMAR_0085|M.marinum_M CVSAGNFGQADALLDESAAIIAATG-APPRPAIKTYLAAYRGQEQICREG
Mflv_1156|M.gilvum_PYR-GCK AIWRGRYAEADAYAADTMERAEQLG--GSMVIAFSICAAVAAYRGREDQA
MUL_2555|M.ulcerans_Agy99 QLASGQWAEAVDTSQRGVALCSQHHYELFGYQLRGYLGVISACRGDVVRA
MAV_2364|M.avium_104 QLTRGELQEACATLDRSISQLSQGFPLPWQLVVGALQAQAEGARGDSAAA
MLBr_02341|M.leprae_Br4923 EITR-ELAERGVLTGE-RGRYACSTDVAEVCVPATLQATIAARIDRLSPP
: . .
Mb2515c|M.bovis_AF2122/97 AAAQASIDTAVGLSPV--LSGSACSALVFATLAAGDVAAAEHARESATRF
Rv2488c|M.tuberculosis_H37Rv AAAQASIDTAVGLSPV--LSGSACSALVFATLAAGDVAAAEHARESATRF
TH_3225|M.thermoresistible__bu IEAAAADGEARGEGRL--MGLTGYAAALLYN-GIGRYREALAAARTTCEY
Mvan_5002|M.vanbaalenii_PYR-1 IEAAIADANARGEGRV--LGAADYAFAVLYN-GLGRYQEACSAARRACEY
MAB_3361|M.abscessus_ATCC_1997 IDEAMRDGAARGEGRL--LGAMGYAAGVLNN-SLGRYELAFMAARRACEH
MSMEG_4053|M.smegmatis_MC2_155 AAAALRDGLQRGEGRV--IALAAYANGVLNN-GLGRYDVAMEALQPACEY
MMAR_0085|M.marinum_M VQQTVDSAASRGEGYD--VSVAMYAAAILHN-GLGQYQEAFNAAASGARY
Mflv_1156|M.gilvum_PYR-GCK RDQAAGALAQGGDYVA--LTVWASATLAFLEVSRGNYEQALEAAEPLVDL
MUL_2555|M.ulcerans_Agy99 RELAAQVRVWAEPRRVGFLTGAVAQIAILCSFAEGDYESAYLQATAITAP
MAV_2364|M.avium_104 AVALRRVEEAYGPHVAVFLPELELARAWERAAAGDTAGAQTQAMQAAQTA
MLBr_02341|M.leprae_Br4923 AKQLLVAAAVIG---------FRFGSDLLASLGIDLSVDELIDANLVDQV
. .
Mb2515c|M.bovis_AF2122/97 FGAS-----AAAIINDPTSSAQISCARGDLNAAHRLADGAASITRGVHRA
Rv2488c|M.tuberculosis_H37Rv FGAS-----AAAIINDPTSSAQISCARGDLNAAHRLADGAASITRGVHRA
TH_3225|M.thermoresistible__bu EDLG-----FYSWCLHELVEAAARVGETDTAHRALGDIEERAGASGTPWG
Mvan_5002|M.vanbaalenii_PYR-1 EDLG-----VHSWVLAELVEAADHCGDTALAVSALERLQERTADTGTDWG
MAB_3361|M.abscessus_ATCC_1997 EDLG-----LYSWCLIELIEAAVRCGEHDTAVKAFGQLEERALAAQSDWS
MSMEG_4053|M.smegmatis_MC2_155 DDLG-----IVGWNLSELVECAVRAGRDDLAADALNKLKLRIGAASTPWG
MMAR_0085|M.marinum_M DDVG-----MCGYLLGELIEAAVRCKEHNAATEALGRLLKRTKASGTPTA
Mflv_1156|M.gilvum_PYR-GCK YRDFPGTELMSACFMPDAIESLIAVGRLDEAEPLIAAFERNGAELDRPWQ
MUL_2555|M.ulcerans_Agy99 GEFPP-LALHATRTLFDLVEAAVHTDRLNEARRHVRAAKRLQFADAPPRL
MAV_2364|M.avium_104 RKAG------MHLVEMRARHAALRFG----DRAQAARVDELASILNSPSA
MLBr_02341|M.leprae_Br4923 RFTAP----VEYAFRHPLIRTVAYESQLKSDRARLHRRLAAAIEARAPHS
Mb2515c|M.bovis_AF2122/97 RALTTRCRIEIA--QGDRHRAERDAHDALGVAASIGAYLWVPDILECLAS
Rv2488c|M.tuberculosis_H37Rv RALTTRCRIEIA--QGDRHRAERDAHDALGVAASIGAYLWVPDILECLAS
TH_3225|M.thermoresistible__bu LGALAGARALLA--DGD--EADRLFREALDHLSRSRVVVHRARVHLTYGE
Mvan_5002|M.vanbaalenii_PYR-1 LGTLAGAQALVA--DDD--HAEALFEESIDRLARTRVAVHLARAHLRYGE
MAB_3361|M.abscessus_ATCC_1997 QGMVARSRALIT--VGH--DAEPHYREAIQRLTNTRISAHLARAHLIYGE
MSMEG_4053|M.smegmatis_MC2_155 LGIAARSAALLA--ADD--AAEPLYLDAIGHLGRSRVKVQLARAHLLYGE
MMAR_0085|M.marinum_M LGIGASATALVS--DGS--IADAAYREAITHLRRSPVAVHLARTHLTYGE
Mflv_1156|M.gilvum_PYR-GCK LAIGNRCRAMLLSATGDLDGALAAAERAMAEHARLPMPFERARSALTLGE
MUL_2555|M.ulcerans_Agy99 AIATGAAEALCAS--DE--RAPALFEKVLGHPAVASFPFEHARIRLAYGM
MAV_2364|M.avium_104 QAVAGHARGLAQ-------HDGDLLDAAAHRFADLGALAFAADAAAQAAS
MLBr_02341|M.leprae_Br4923 VDQHAVLIAEHL--------------EAAGDLHAAYGWHMRAAAWATNQD
.
Mb2515c|M.bovis_AF2122/97 VMADAGSNREAVRLFGAADAARGRMGAVRFGIYQAGCNSSLATLRKSMGD
Rv2488c|M.tuberculosis_H37Rv VMADAGSNREAVRLFGAADAARGRMGAVRFGIYQAGCNSSLATLRKSMGD
TH_3225|M.thermoresistible__bu WLRREHRRGEARRELNEAHGMFTRMGAQGFAERSR---------------
Mvan_5002|M.vanbaalenii_PYR-1 WLRRALRRNDAREQLTLASGMFTRFGAAAFAERTR---------------
MAB_3361|M.abscessus_ATCC_1997 WLRRCNRRSDARTELTAAHGSFVNMGTAAFAERAE---------------
MSMEG_4053|M.smegmatis_MC2_155 WLRRMNRRNDARHHLRLAHEMLQGFGVNAFADRAA---------------
MMAR_0085|M.marinum_M WLRRERRRSEARSQLRIAYDMFAQMGAAGFAERAR---------------
Mflv_1156|M.gilvum_PYR-GCK VLRRLRRR-DAAAAVRDALAQFEELGVPLWVARAR---------------
MUL_2555|M.ulcerans_Agy99 RLRRLRRYRNARVVLRAAAEIFAGLGAEPWTQRAR---------------
MAV_2364|M.avium_104 EHARRGDRRKEVESSTWAHALAGQCGSRTPALDAA---------------
MLBr_02341|M.leprae_Br4923 VRAARVSWEHATKIADALTAEDPHRAAMCIAPRTR---------------
. .
Mb2515c|M.bovis_AF2122/97 SEFDDAWAEGTALSIDEAIAYAQRGRGARKRPTSGWGALTPTELEVALLV
Rv2488c|M.tuberculosis_H37Rv SEFDDAWAEGTALSIDEAIAYAQRGRGARKRPTSGWGALTPTELEVALLV
TH_3225|M.thermoresistible__bu ------------------RELIAVGEKVRRQPLTSGDELTAQEAQIAGLA
Mvan_5002|M.vanbaalenii_PYR-1 ------------------RELIATGEKARRQPVTSGAQLTAQESQIARLA
MAB_3361|M.abscessus_ATCC_1997 ------------------RELRATGAKVRKRSASSEKALTAQEAQIARMA
MSMEG_4053|M.smegmatis_MC2_155 ------------------RELIPLGEKTVKR-KRTGTALTPQETQVAQLA
MMAR_0085|M.marinum_M ------------------RELSATGEAVYVQPTGITVDLTTQESHIARLA
Mflv_1156|M.gilvum_PYR-GCK --------------------IALSG--LAVSGSAVGSELTDSERRIAELA
MUL_2555|M.ulcerans_Agy99 ------------------NELRAAGTAVRHSAAVGPAPLTAQERLVAELA
MAV_2364|M.avium_104 ---------------------------------ARPLPFSGRERQIVNLV
MLBr_02341|M.leprae_Br4923 ---------------------------------LCGIAWRGRFNSSSGFD
:
Mb2515c|M.bovis_AF2122/97 GEGLSNKEIGVRLFISPRTVHSHLTHVYTKLGLSSRLQLAQQAARRGESE
Rv2488c|M.tuberculosis_H37Rv GEGLSNKEIGVRLFISPRTVHSHLTHVYTKLGLSSRLQLAQQAARRGESE
TH_3225|M.thermoresistible__bu ADGLTNQEIGAQLFLSVHTVEWHLRKVFVKLGITSRRQLRAAPRVTATW-
Mvan_5002|M.vanbaalenii_PYR-1 GDGLTNQEIGAQLFISTHTVDWHLRKVFVKLGITSRRQLRSASWAS----
MAB_3361|M.abscessus_ATCC_1997 GQGLTNQEIAAQLFISSHTVEWHLRKVFAKRGITSRRQLRSGR-------
MSMEG_4053|M.smegmatis_MC2_155 AAGLTNTEIGSQLFISAHTVEWHLSNVYAKLAIKSRRQLRAMKLR-----
MMAR_0085|M.marinum_M RDGYTNAEIAGLLFISARTVEWHLSKIFAKLGVTSRRELRAILMESP---
Mflv_1156|M.gilvum_PYR-GCK ASGMSNRDVAETLFVSVKTIETNLSRVYRKLGIRSRAQLGRMLR------
MUL_2555|M.ulcerans_Agy99 AKGLSNKEIAARLCLSPRTVGAHLYRLFPKLGVTNRAGLHDALDAIHAAP
MAV_2364|M.avium_104 AAGLSNREIADRLVISVRTVEGHLYRLFTKLGINNRDQLIQLIRRDAS--
MLBr_02341|M.leprae_Br4923 EVRQLCNATGDKAPLAVATVGPAIDHVYQDRLH-----------------
. :: *: : .:: .
Mb2515c|M.bovis_AF2122/97 RGPSRP
Rv2488c|M.tuberculosis_H37Rv RGPSRP
TH_3225|M.thermoresistible__bu ------
Mvan_5002|M.vanbaalenii_PYR-1 ------
MAB_3361|M.abscessus_ATCC_1997 ------
MSMEG_4053|M.smegmatis_MC2_155 ------
MMAR_0085|M.marinum_M ------
Mflv_1156|M.gilvum_PYR-GCK ------
MUL_2555|M.ulcerans_Agy99 DQI---
MAV_2364|M.avium_104 ------
MLBr_02341|M.leprae_Br4923 ------