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M. smegmatis MC2 155 MSMEG_0576 (-)

annotation: MmpL4 protein
coordinates: 649975 - 652866
length: 963

MIQGLHNRSDSRPLLPHALRVLAIPVILFWVAFAAVVNIIAPQLEIVGEEHSAPMAPEDAPSLTGMHRMG
GNFQEFDSNSTVMVVIEGQEPLGPDAHAYYDEIIRKLRQDPEHIQHIQDFWGDTLTAAGAQSADGKAAYV
MLNLAGEQGQTLANDGVQEVRQVIADTPAPPGVQAYAAGPAALTDDLHVIGNASLGKITLFTLVAIAVML
LIVYRSIVTTLIQLVLTGVGLLASRGLISVLATHDVFGLTTFAGNILTMLAIAAATDYGIFLFGRYREAR
GAGEDPETAYYTTFKSVSPVIVGSGLTIAGATYCLSFARLPYFSTMGAPVAIGMIVVVASSVTMGPAVLF
LGSKVGLYEAKRAAKGRFWRRVGTAVVRWPAPILVASAFIVLIGVVAVPGYRPAYNDRWYLPDDAPVNIG
FAAADRHFTQARMNPDILMVEADHDMRNPADMLVLDRVAKNVLRTQGIAMVQSITRPLGIPIQHSSIPFQ
TAIQGQTSNLNLPFQRAQLDNQLKMVEATNQSIAIMEKQYELSLRQTKLTQDSAEKSRELLEVTKQLRDN
IANFDDQFRPLRNYFYWEPHCFDIPMCAAARSLFDSLDTVDELTDRTSAVQVNTDELADLAPQLTALLPQ
TIASMKTSRDLSLASYNSQKALLDQMQAMNDTALAMGQSFDEAKNDDFFYLPPEAFQNPDFERGLKMFLS
PDGKSARMFITHQSDPATPEGIARVNAERTAAQEGLKMSSLSDAKIFLGGTAATYKDMSDGARYDLMIAV
VSALTLIFMIMLILTRSAVAALVIVGTAASSIAASFGISVLLWQDLFGVEVHWLVMLMSVIILLAVGSDY
NLLLVSRFKDEIHAGLKTGIIRSMAGTGGVVTSAGLVFAATMAAMLGSELVVLAQMGSTIAIGLLLDTLI
VRSLLMPSIATLLGRWFWWPQVVYPRGDNHFRRPTAVSRGTGDEDTAALPVPS
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_0576--100% (963)MmpL4 protein
M. smegmatis MC2 155MSMEG_3496-0.055.06% (919) MmpL4 protein
M. smegmatis MC2 155MSMEG_0382-0.055.13% (936) putative transport protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1583mmpL60.054.79% (940) transmembrane transport protein MmpL6
M. gilvum PYR-GCKMflv_4418-0.054.87% (913) transport protein
M. tuberculosis H37RvRv0450cmmpL40.054.84% (930) transmembrane transport protein MmpL4
M. leprae Br4923MLBr_02378-0.053.86% (919) hypothetical protein MLBr_02378
M. abscessus ATCC 19977MAB_0987c-0.053.66% (943) membrane protein MmpL
M. marinum MMMAR_3744mmpL4_10.069.43% (929) transmembrane transport protein MmpL4_1
M. avium 104MAV_1755-0.068.73% (937) MmpL4 protein
M. thermoresistible (build 8)TH_3260-0.052.44% (921) PUTATIVE MmpL4 protein
M. ulcerans Agy99MUL_3688mmpL4_10.069.11% (929) transmembrane transport protein MmpL4_1
M. vanbaalenii PYR-1Mvan_3189-0.054.62% (930) transport protein

CLUSTAL 2.0.9 multiple sequence alignment


Rv0450c|M.tuberculosis_H37Rv        -------------------MSTKFANDSNTNARPEK----------PFIA
MLBr_02378|M.leprae_Br4923          -------------------MTVKCANDLDTHTKP------------PFVA
TH_3260|M.thermoresistible__bu      -------------------MTANPGHVRTDEAPTDRLDIKVSTHGPSFIS
Mvan_3189|M.vanbaalenii_PYR-1       -------------------MSAPVSDARTDEFPAAR-----QPHRP-FIP
Mflv_4418|M.gilvum_PYR-GCK          --------------------MADAGRSG--------------------IG
Mb1583|M.bovis_AF2122/97            -------------------MSNHHRPRP-------------------WLP
MAB_0987c|M.abscessus_ATCC_199      -------------------MSANHAHES-------------------RAA
MMAR_3744|M.marinum_M               MSESN--SGASISTEDTGPIEIGAATGGAPNRERGH---------RPVIP
MUL_3688|M.ulcerans_Agy99           MSESN--SGASISTEDTGPIEIGAATGGAPNRERGH---------RPVIP
MAV_1755|M.avium_104                MSDASNKTQPDLSAADTGPINVKGLS----KAERGH---------RPYLP
MSMEG_0576|M.smegmatis_MC2_155      --------------------MIQGLH-----NRSDS---------RPLLP
                                                                                      

Rv0450c|M.tuberculosis_H37Rv        RMIHAFAVPIILGWLAVCVVVTVFVPSLEAVGQERSVSLSPKDAPSFEAM
MLBr_02378|M.leprae_Br4923          RMIHRFAVPIILVWLAIAVTVSVFIPSLEDVGQERSVSLSPKDAPSYIAM
TH_3260|M.thermoresistible__bu      TWIRRLSLPIIVGWIALIALLNITVPQLEVVGEMRAVSMSPDEAPSMVAM
Mvan_3189|M.vanbaalenii_PYR-1       RMIRLFAVPIILGWIALIVILNVTVPQLEAVGEARAVSMSPNEAPSLISM
Mflv_4418|M.gilvum_PYR-GCK          RIIRVLAVPIVLGWVLLTVLTNVAVPSLEKVGEEHTVGMSAGDAPSMMSM
Mb1583|M.bovis_AF2122/97            HTIRRLSLPILLFWVGVAAITNAAVPQLEVVGEAHNVAQSSPDDPSLQAM
MAB_0987c|M.abscessus_ATCC_199      KIVRRLAVPIVLFWVAIAAVTNATVPQLEVVGEERSAPLNAADAPSTLAM
MMAR_3744|M.marinum_M               HTIRILAVPIILGWVLLTVLVNVVVPSLEVVSEQHSAPMTPMDAPSMKAM
MUL_3688|M.ulcerans_Agy99           HTIRILAVPIILGWVLLTVLVNVVVPSLEVVSEQHSAPMTPMDAPSMKAM
MAV_1755|M.avium_104                HAIRIFAVPIILGWLFVTVLVNVIVPTLEKVGEAHSAPMTPLDAPSMKAM
MSMEG_0576|M.smegmatis_MC2_155      HALRVLAIPVILFWVAFAAVVNIIAPQLEIVGEEHSAPMAPEDAPSLTGM
                                      :: :::*::: *: . .  .   * ** *.: : .   . : **  .*

Rv0450c|M.tuberculosis_H37Rv        GRIGMVFKEGDSDSFAMVIIEGNQPLGDAAHKYYDGLVAQLRADKKHVQS
MLBr_02378|M.leprae_Br4923          QKMGQVFNEGNSDSVIMIVLEGDKPLGDDAHRFYDGLIRKLRADK-HVQS
TH_3260|M.thermoresistible__bu      KRVGELFDEGSSDSQVMIVLEGEEPLGADARAFYDELVKRLEADDAHVEN
Mvan_3189|M.vanbaalenii_PYR-1       KKVGELFREGDSDSSVMIVFEGDQPLGDEAHAWYDELVERLRADTKHVQS
Mflv_4418|M.gilvum_PYR-GCK          KRVGANFEEFDSDSSAMVVLEGEQPLGDAAHRYYDQLIDELEADTANVQH
Mb1583|M.bovis_AF2122/97            KRIGKVFHEFDSDSAAMIVLEGDKPLGNDAHRFYDTLLRNLSNDTKHVEH
MAB_0987c|M.abscessus_ATCC_199      RHIGKVFNEFDSDSSAMVVLEGEKPLGAQAHQFYNTLVQRLNDDHEHVQH
MMAR_3744|M.marinum_M               MRLGHNFREFDSNSTVMIVLEGQHKLGDDAHQYYDSLIRQLRQDPEHIQH
MUL_3688|M.ulcerans_Agy99           MRLGHNFREFDSNSTVMIVLEGQHKLGDDAHQYYDSLIRQLRQDPEHIQH
MAV_1755|M.avium_104                MRLGHNFHEFDSNSTVMIVLEGQQPLGPDAHKYYDNLIRQLRQDPKHIQH
MSMEG_0576|M.smegmatis_MC2_155      HRMGGNFQEFDSNSTVMVVIEGQEPLGPDAHAYYDEIIRKLRQDPEHIQH
                                     ::*  * * .*:*  *:::**:. **  *: :*: :: .*  *  ::: 

Rv0450c|M.tuberculosis_H37Rv        VQDLWGDPLTAAGVQSNDGKAAYVQLSLAGNQGTPLANESVEAVRSIVES
MLBr_02378|M.leprae_Br4923          VQDFWGDPLTAPGAQSNDGKAAYVQLSLAGNQGELLAQESIDAVRKIVVQ
TH_3260|M.thermoresistible__bu      VQDLWSDPLTATGVQSPDGKSAYVQVKLAGNQGEALANESVETVREMIAT
Mvan_3189|M.vanbaalenii_PYR-1       VQDFWSDPLTASGSQSNDGKAAYVQVKLAGNQGESLANESVQAAQEIVRS
Mflv_4418|M.gilvum_PYR-GCK          IADFWGDPLTASGAQSTDGKAAYVQVYLQGNQGEPRANEAVAAVREIVDR
Mb1583|M.bovis_AF2122/97            VQDFWGDPLTAAGSQSTDGKAAYVQVYLAGNQGEALSIESVDAVRDIVAH
MAB_0987c|M.abscessus_ATCC_199      VADYWGDPITAGGSQSKDGKAAYVQVYVAGNQGEALSNESVDAVRRIIAE
MMAR_3744|M.marinum_M               IQDFWGDRLTAAGAQSADGKSAYVMVNLAGNQGTTLANESVEAVRDVINR
MUL_3688|M.ulcerans_Agy99           IQDFWGDRLTAAGAQSADGKSAYVMVNLAGNQGTTLANESVEAVRDVINR
MAV_1755|M.avium_104                IQDFWGDRLTAAGAQSADAKGAYVQVNLAGNQGTTLANESVDAVRKVIDE
MSMEG_0576|M.smegmatis_MC2_155      IQDFWGDTLTAAGAQSADGKAAYVMLNLAGEQGQTLANDGVQEVRQVIAD
                                    : * *.* :** * ** *.*.*** : : *:**   : :.:  .: ::  

Rv0450c|M.tuberculosis_H37Rv        TP---APPGIKAYVTGPSALAADMHHSGDRSMARITMVTVAVIFIMLLLV
MLBr_02378|M.leprae_Br4923          TP---APPGITAWVTGASALIADMHHSGDKSMIRITATSVIVILVTLLLV
TH_3260|M.thermoresistible__bu      VSEEMAPEGVQAFVTGGAAMSADQQEAGDSSLRVIEALTFLVITTMLLFV
Mvan_3189|M.vanbaalenii_PYR-1       LE---PPPGVRAFVTGPAALAADQHIASDRSVRVIELVTFAVIIVMLLLV
Mflv_4418|M.gilvum_PYR-GCK          TP---APPGIKAYVTGGAPLVADQHSAGDTSVLRVTLITIGVIAVMLLIV
Mb1583|M.bovis_AF2122/97            TP---PPAGVKAYVTGAAPLMADQFQVGSKGTAKVTGITLVVIAVMLLFV
MAB_0987c|M.abscessus_ATCC_199      TP---APDGIKAYVSGEAPTITDQFEVGNAGAAQVTIITFAVIAVMLLVV
MMAR_3744|M.marinum_M               TH---EPAGVKAYVTGPAALSDDMHLIGNASLAKITMFTLGAIAVMLLLV
MUL_3688|M.ulcerans_Agy99           TH---EPAGVKAYVTGPAALSDDMHLIGNASLATITMFTLGAIAVMLLLV
MAV_1755|M.avium_104                NK---APPGVKAYVTGPAALSDDMHIIGNASLAKITLFTLGAIAIMLLLV
MSMEG_0576|M.smegmatis_MC2_155      TP---APPGVQAYAAGPAALTDDLHVIGNASLGKITLFTLVAIAVMLLIV
                                          * *: *:.:* :.   *    .. .   :   :. .*   **.*

Rv0450c|M.tuberculosis_H37Rv        YRSIITVVLLLITVGVELTAARGVVAVLGHSGAIGLTTFAVSLLTSLAIA
MLBr_02378|M.leprae_Br4923          YRSFITVILLLFTVGIESAVARGVVALLGHTGLIGLSTFAVNLLTSLAIA
TH_3260|M.thermoresistible__bu      YRSVITVLIALFMVLIGLLTTRGVVAFLGYHNIIGLSTFATSLLVTLAIA
Mvan_3189|M.vanbaalenii_PYR-1       YRSIVTVLLTLVMVVLSLATARGVVAFLGWHEIIGLSLFATNLLVTLAIA
Mflv_4418|M.gilvum_PYR-GCK          FRSVATMVLILFMVFAELGAARGIVAFLADAEIIGLSTFATSLLTLMVIA
Mb1583|M.bovis_AF2122/97            YRSVVTMVLVLITVLIELAAARGIVAFLGNAGVIGLSTYSTNLLTLLVIA
MAB_0987c|M.abscessus_ATCC_199      YRSLITTALVLAMVMVELSAARGIVAALGHTGVIGLSTYATNLLTMLAIA
MMAR_3744|M.marinum_M               YRSIVTTVIQLFMTGIALASSRGVVAVLGYHNVFGLTTFAANILTMLAIA
MUL_3688|M.ulcerans_Agy99           YRSIVTTVIQLFMTGIALASSRGVVAVLGYHNVFGLTTFAANILTMLAIA
MAV_1755|M.avium_104                YRSIVTTLVQLFMTFVALACSRGVVAVLAYHNAFGLTTFAANILTMLAIA
MSMEG_0576|M.smegmatis_MC2_155      YRSIVTTLIQLVLTGVGLLASRGLISVLATHDVFGLTTFAGNILTMLAIA
                                    :**. *  : *  .      :**::: *.    :**: :: .:*. :.**

Rv0450c|M.tuberculosis_H37Rv        AGTDYGIFIIGRYQEARQAGEDKEAAYYTMYRGTAHVILGSGLTIAGATF
MLBr_02378|M.leprae_Br4923          AGTDYGIFITGRYQEARQANENKEAAFYTMYRGTFHVILGSGLTISGATF
TH_3260|M.thermoresistible__bu      IAVDYAIFLIGRYQEARSVGADRATAYHTMFGGTAHVILASGLTIAGATF
Mvan_3189|M.vanbaalenii_PYR-1       AATDYAIFLIGRYQEARTNGEDKESAYYTMFHGTAHVVLGSGLTIAGATY
Mflv_4418|M.gilvum_PYR-GCK          AGTDYAIFAIGRYQEARGAGEDRETAYYTMFRGTAHVVLGSGLTIAGAML
Mb1583|M.bovis_AF2122/97            AGTDYAIFVLGRYHEARYAAQDRETAFYTMYRGTAHVVLGSGLTVAGAVY
MAB_0987c|M.abscessus_ATCC_199      AGTDYAIFFVGRYQEARSAGEDRPSAYQTMYKSTAHVIIGSGLTVAGALF
MMAR_3744|M.marinum_M               AGTDYGIFLVGRYQEARQAGEDREDAYYTTFRGVAPVVLGSGLTIAGATY
MUL_3688|M.ulcerans_Agy99           AGTDYGIFLVGRYQEARQAGEDRQDAYYTTFRGVAPVVLGSGLTIAGATY
MAV_1755|M.avium_104                AGTDYGIFLIGRYQEALAAGEDRESAYYTTFKGVAPVVLGSGLTIAGATY
MSMEG_0576|M.smegmatis_MC2_155      AATDYGIFLFGRYREARGAGEDPETAYYTTFKSVSPVIVGSGLTIAGATY
                                     ..**.**  ***:**     :   *: * : ..  *::.****::**  

Rv0450c|M.tuberculosis_H37Rv        CLSFARMPYFQTLGIPCAVGMLVAVAVALTLGPAVLHVGSRFG-LFDPKR
MLBr_02378|M.leprae_Br4923          CLSFARMPYFQTLGVPCAVGMLIAVAVALTLGPAVLTVGSRFG-LFEPKR
TH_3260|M.thermoresistible__bu      CLSFTRLPYFQSLGPPLAIGMIVLIVTSLTMGPAIITVATRFG-LLEPKR
Mvan_3189|M.vanbaalenii_PYR-1       CLSFTRLPYFQTLGVPLAIGMFVVVMAGVILMVAMISVATRFGKLLEPKR
Mflv_4418|M.gilvum_PYR-GCK          CLSFTRLPYFQTMGVPCAVGTFVAVIAALTLGPAVIVIGSRFG-LFDPKR
Mb1583|M.bovis_AF2122/97            CLSFTRLPYFQSLGIPASIGVMIALAAALSLAPSVLILGSRFG-CFEPKR
MAB_0987c|M.abscessus_ATCC_199      CLSFTRLPYFQTLGVPAALGVLVTLAAALTLAPAVLVIAGRFG-LMEPKR
MMAR_3744|M.marinum_M               CLSFARLPWFNTMGAPVAIGMLVVVLAGLTLGPAVVFVGSRFH-LFESKR
MUL_3688|M.ulcerans_Agy99           CLSFARLPWFNTMGAPVAIGMLVVVLAGLTLGPAVVFVGSRFH-PFESKR
MAV_1755|M.avium_104                CLSFSRLPWFNTMGAPVAIGMLVVVLAGVTLGPAVVFVGSRFH-FFE--R
MSMEG_0576|M.smegmatis_MC2_155      CLSFARLPYFSTMGAPVAIGMIVVVASSVTMGPAVLFLGSKVG-LYEAKR
                                    ****:*:*:*.::* * ::* :: :  .: :  ::: :. :.    :  *

Rv0450c|M.tuberculosis_H37Rv        LLK-VRGWRRVGTVVVRWPLPVLVATCAIALVGLLALPGYKTSYNDRDYL
MLBr_02378|M.leprae_Br4923          LIK-VRGWRRIGTVVVRWPLPILITTCAIAMVGLLALPGYRTNYKDRAYL
TH_3260|M.thermoresistible__bu      AAR-VRFWRKVGASVVRWPGPIMVTTVAVTLVGLLALPGYRTNYNDRNYL
Mvan_3189|M.vanbaalenii_PYR-1       AMR-IRGWRKIGAAVVRWPGPILVATLAITLVGLLALPGYKTNYNDRTYL
Mflv_4418|M.gilvum_PYR-GCK          AIS-SRGWRRIGVSVVRWPGPVLAATLALALVGLVTLPGYKTNYDARDYL
Mb1583|M.bovis_AF2122/97            RMR-TRGWRRIGTAIVRWPGPILAVACAIAVVGLLALPGYKTSYDARYYM
MAB_0987c|M.abscessus_ATCC_199      AMR-TRGWRRIGTAIVRWPGPILVVSCIATLVGLLALPGYRTTYDGRIYM
MMAR_3744|M.marinum_M               AANRGRLWRRVGTAVVRWPAPILALSGAIVLVGMVALPGFKTSYNDRYYL
MUL_3688|M.ulcerans_Agy99           AANRGRLWRRVGTAVVRWPAPILALSGAIVLVGMVALPGFKTSYNDRYYL
MAV_1755|M.avium_104                QAKRGRLWRRVGTAVVRWPAPVLAVSAAVVLVGMIALPSFHTSYNDRHYL
MSMEG_0576|M.smegmatis_MC2_155      AAK-GRFWRRVGTAVVRWPAPILVASAFIVLIGVVAVPGYRPAYNDRWYL
                                         * **::*. :**** *::  :   .::*::::*.::. *. * *:

Rv0450c|M.tuberculosis_H37Rv        PDFIPANQGYAAADRHFSQARMKPEILMIESDHDMRNPADFLVLDKLAKG
MLBr_02378|M.leprae_Br4923          PASIPANQGFAAADRHFPQARMKPEILMIESDHDMRNPADFLILDKLARG
TH_3260|M.thermoresistible__bu      PASFPSNAGYEAAERHFDPARLNPELLLIESDHDLRNPADFLVIEKIAKA
Mvan_3189|M.vanbaalenii_PYR-1       PADLPANEGYAVADRHFDQARMNPELLMIESDHDLRNSADFLVIDKIAKA
Mflv_4418|M.gilvum_PYR-GCK          PEDIPANVGYAVADQHFGSARMNPELLMVESDHDLRNPADFLVIDKIAKS
Mb1583|M.bovis_AF2122/97            PATAPANIGYMAAERHFPQARLNPELLMIETDHDMRNPADMLILDRIAKA
MAB_0987c|M.abscessus_ATCC_199      PSSVPSNVGYAAAERHFSVARLNPELLMIETDFDMRNPAGMVLLERVAKS
MMAR_3744|M.marinum_M               PASAPSNLGEAAADRHFSHARMNPDMLMVEAEHDMRNPADMLVLDKVAKN
MUL_3688|M.ulcerans_Agy99           PASAPSNLGEAAADRHFSHARMNPDMLMVEAEHDMRNPADMLVLDKVAKN
MAV_1755|M.avium_104                PLSAPSNQGQEAANRHFSEARMNPDLLMIESDHDMRNPADMLVLDRVAKN
MSMEG_0576|M.smegmatis_MC2_155      PDDAPVNIGFAAADRHFTQARMNPDILMVEADHDMRNPADMLVLDRVAKN
                                    *   * * *  .*::**  **::*::*::*::.*:**.*.:::::::*: 

Rv0450c|M.tuberculosis_H37Rv        IFRVPGISRVQAITRPEGTTMDHTSIPFQISMQNAGQLQTIKYQRDRAND
MLBr_02378|M.leprae_Br4923          IFRVPGISRVQAITRPDGTAMDHTSIPFQISMQNAGQVQTMKYQKDRMND
TH_3260|M.thermoresistible__bu      VFQVEGISRVQGITRPEGTPIEHSSIPFMISQQGTLQILNQQYMQDRMAD
Mvan_3189|M.vanbaalenii_PYR-1       IFKVEGIARVQAITRPDGKPIKHTSIPFQMSMQGTTQRLNEKYMQDRMAD
Mflv_4418|M.gilvum_PYR-GCK          VFRVPGVARVQTITRPDGKPIKHTTIPFQMSMQGTTQRLNEKYLQDRMAD
Mb1583|M.bovis_AF2122/97            VFHLPGIGLVQAMTRPLGTPIDHSSIPFQISMQSVGQIQNLKYQRDRAAD
MAB_0987c|M.abscessus_ATCC_199      VLHARGVALVQSITRPLGTPITHSSIPFQISASSASQLMNLSQQQNQALY
MMAR_3744|M.marinum_M               VIRTVGIAMIQDITRPLGIPIQHSSIPFQNSMQSQTMMQNMAFLKERMAD
MUL_3688|M.ulcerans_Agy99           VIRTVGIAMIQDITRPLGIPIQHSSIPFQNSMQSQTMMQNMAFLKERMAD
MAV_1755|M.avium_104                EMRTLGIAMVQDITRPLGIPIQHSSIPFQNSVQSQTTMQNMGFLKERMND
MSMEG_0576|M.smegmatis_MC2_155      VLRTQGIAMVQSITRPLGIPIQHSSIPFQTAIQGQTSNLNLPFQRAQLDN
                                     ::  *:. :* :*** * .: *::***  : ..     .    : :   

Rv0450c|M.tuberculosis_H37Rv        MLKQADEMATTIAVLTRMHSLMAEMASTTHRMVGDTEEMKEITEELRDHV
MLBr_02378|M.leprae_Br4923          LLRQAENMAETIASMRRMHQLMALLTENTHHILNDTVEMQKTTSKLRDEI
TH_3260|M.thermoresistible__bu      MLVQADEMQLMIDTMDKMIALMEEMVETTDNMVRDMDEMAAHVAEMRDSI
Mvan_3189|M.vanbaalenii_PYR-1       MLVQADEMANTIATMEKMSNLTAQMADITHSMVSKMENMLTDIEDLRDSI
Mflv_4418|M.gilvum_PYR-GCK          MLVQADAMQTNVDTMTRMQSLMGQMSATTHEMVLKTKKTEIDIIEVRDNL
Mb1583|M.bovis_AF2122/97            LLKQAEELGKTIEILQRQYALQQELAAATHEQAESFHQTIATVKELRDRI
MAB_0987c|M.abscessus_ATCC_199      LSQQADQMTNTIAVLRQQLALQKQSAAITHEQTEGFQQTVAVAQDLRDKI
MMAR_3744|M.marinum_M               MTKMADEMQVLIDTTERMYAVMRDLDTTTTDMARVTAETSTITDELRDHL
MUL_3688|M.ulcerans_Agy99           MTKMADEMQVLIDTTERMYAVMRELDTTTTDMARVTAETSTITDELRDHL
MAV_1755|M.avium_104                ILKMADDLQTQIDTTQRQYEVSMDLANAADDSAKTTAVTSQITDSLRDHI
MSMEG_0576|M.smegmatis_MC2_155      QLKMVEATNQSIAIMEKQYELSLRQTKLTQDSAEKSRELLEVTKQLRDNI
                                        .:     :    :   :       :               .:** :

Rv0450c|M.tuberculosis_H37Rv        ADFDDFWRPIRSYFYWEKHCYGIPICWSFRSIFDALDGIDKLSEQIGVLL
MLBr_02378|M.leprae_Br4923          ANFDDFWRPIRSYFYWERHCFNIPICWSFRSIFDALDGVDQIDERLNSIV
TH_3260|M.thermoresistible__bu      SEFDDFFRPIRNYFYWEPHCYNIPVCWAMRSVFDTLDGINTMTDDIQNML
Mvan_3189|M.vanbaalenii_PYR-1       ANFDDFFRPIRNYFYWEPHCYNIPVCWALRSVFDTLDGINVMTDDFREIL
Mflv_4418|M.gilvum_PYR-GCK          ADFDDFFRPVRNYFYWEPHCYDIPVCWTMRSVFDTLDGINPLTDDISELI
Mb1583|M.bovis_AF2122/97            ANFDDFFRPIRSYFYWEKHCYDIPSCWALRSVFDTIDGIDQLGEQLASVT
MAB_0987c|M.abscessus_ATCC_199      ANFDDQFRPIRNYFYWEPHCFDIPFCAALRSVFDALDGIDELVDALQSVT
MMAR_3744|M.marinum_M               AEFDDFWRPMRSYFYWEKHCFDVPICWSFRSLFDSLDGIDKLSEKFSELT
MUL_3688|M.ulcerans_Agy99           AEFDDFWRPMRSYFYWEKHCFDVPICWSFRSLFDSLDGIDKLSEKFSELT
MAV_1755|M.avium_104                ADFDDTFRPIRTYFYWEKHCYDIPVCIGLRSLFDTFDGFDQLAEQFHYLT
MSMEG_0576|M.smegmatis_MC2_155      ANFDDQFRPLRNYFYWEPHCFDIPMCAAARSLFDSLDTVDELTDRTSAVQ
                                    ::*** :**:*.***** **:.:* *   **:**::* .: : :    : 

Rv0450c|M.tuberculosis_H37Rv        GDLREMDRLMPQMVAQIPPQIEAMENMRTMILTMHSTMTGIFDQMLEMSD
MLBr_02378|M.leprae_Br4923          GDIKNMDLLMPQMLEQFPPMIESMESMRTIMLTMHSTMSGIFDQMNELSD
TH_3260|M.thermoresistible__bu      PHMHRLNDLMPQMLTLLPTTVATMKTMRSMLLTMQATNAGLQDQMAEMQE
Mvan_3189|M.vanbaalenii_PYR-1       PDMKRLDSLMPQMVALMPEMIETMKTMRTMMLTMYQSQKGQQDQMAAMSE
Mflv_4418|M.gilvum_PYR-GCK          PDLERLDELMPQLIALLPSQIETMRSMQAMMLRQYQTQKGQLDQNAAMSE
Mb1583|M.bovis_AF2122/97            VTLDKLAAIQPQLVALLPDEIASQQINRELALANYATMSGIYAQTAALIE
MAB_0987c|M.abscessus_ATCC_199      GSLTKLDALQPKLVDLIPPQIAIQEKNRDLTLSNYAINNGTNTQNEESTR
MMAR_3744|M.marinum_M               EDIQHTAGLTSQMLTLIPPMIATMKTTKALTLTMQSTFSAMLDQMDELSN
MUL_3688|M.ulcerans_Agy99           EDIQRTAGLTSQMLTLIPPMIATMKTTKALTLTMQSTFSAMLDQMDELSN
MAV_1755|M.avium_104                TDIAHTAKASRDLTALFPTLITTLKTTRGITLTLYQTFKAMIDQMEAMSN
MSMEG_0576|M.smegmatis_MC2_155      VNTDELADLAPQLTALLPQTIASMKTSRDLSLASYNSQKALLDQMQAMND
                                        .      .:   :*  :   .  : : *       .   *      

Rv0450c|M.tuberculosis_H37Rv        NATAMGKAFDAAKNDDSFYLPPEVFKNKDFQRAMKSFLSSDGHAARFIIL
MLBr_02378|M.leprae_Br4923          NANTMGKAFDTAKNDDSFYLPPEVFKNTDFKRAMKSFLSSDGHAARFIIL
TH_3260|M.thermoresistible__bu      NANAMGEAFDQARNDDSFYLPPEAFDNPDFQRGLEQFLSPDGHAVRFIIS
Mvan_3189|M.vanbaalenii_PYR-1       DADAMGEAFDDSMNDDSFYLPPEIFENKDFQRGLEQFLSPDGHAVRFIIS
Mflv_4418|M.gilvum_PYR-GCK          DADAMGEAFDDSMNDDSFYLPPEAFDNDDFKRGMENFISPDGRSVRFIIS
Mb1583|M.bovis_AF2122/97            NAAAMGQAFDAAKNDDSFYLPPEAFDNPDFQRGLKLFLSADGKAARMIIS
MAB_0987c|M.abscessus_ATCC_199      TATELGKAFDDAKNDDSFYLPPEAFDNPAFKRGMKLFMSPDGKAARMIIT
MMAR_3744|M.marinum_M               TAIVMGQSFDASKNDDFFYLPPEAFDNPDFQTGLRMFLSPDGKSARFFIT
MUL_3688|M.ulcerans_Agy99           TAIVMGQSFDASKNDDFFYLPPEAFDNPDFQTGLRMFLSPDGKSARFFIT
MAV_1755|M.avium_104                TAVVMGQSFDASKNDDFFYLPPEAFDNPDFQTGLRMFLSPDGKSARFFIT
MSMEG_0576|M.smegmatis_MC2_155      TALAMGQSFDEAKNDDFFYLPPEAFQNPDFERGLKMFLSPDGKSARMFIT
                                     *  :*::** : *** ****** *.*  *: .:. *:*.**::.*::* 

Rv0450c|M.tuberculosis_H37Rv        HRGDPQSPEGIKSIDAIRTAAEESLKGTPLEDAKIYLAGTAAVFHDISEG
MLBr_02378|M.leprae_Br4923          HRGDPASVAGIASINAIRTAAEEALKGTPLEDTKIYLAGTAAVFKDIDEG
TH_3260|M.thermoresistible__bu      HQGDPMTPEGLAKIEPIKKAAVEAIKGTPLEGSRVYLGGTAAVFKDMSDG
Mvan_3189|M.vanbaalenii_PYR-1       HEGDPLSPEGVAKIDKIKTAAKEAIKGTPLEGSKIYLGGTAATFKDMQDG
Mflv_4418|M.gilvum_PYR-GCK          HEGDPATVEGISEVVPIKTAAKEAIKGTPLEGSTVYLAGTAATYKDMSDG
Mb1583|M.bovis_AF2122/97            HEGDPATPEGISHIDAIKQAAHEAVKGTPMAGAGIYLAGTAATFKDIQDG
MAB_0987c|M.abscessus_ATCC_199      HQGDPQTSEGIAHIDAIKEAAFDAVKATPLADAKIYVAGTASAYKDIADG
MMAR_3744|M.marinum_M               HQGDPMTPEGISRVDAERTAAQEGLKQSSLSDAKVYLGGTAATFKDMADG
MUL_3688|M.ulcerans_Agy99           HQGDPMTPEGISRVDAERTAAQEGLKQSSLSDAKVYLGGTAATFKDMADG
MAV_1755|M.avium_104                HQGDPMSPEGIKRVDAERTAAQEGLKQSSLSDARVYLGGTAATFKDMADG
MSMEG_0576|M.smegmatis_MC2_155      HQSDPATPEGIARVNAERTAAQEGLKMSSLSDAKIFLGGTAATYKDMSDG
                                    *..** :  *:  :   : ** :.:* :.: .: :::.***:.::*: :*

Rv0450c|M.tuberculosis_H37Rv        AQWDLLIAAISSLCLIFIIMLIITRAFIAAAVIVGTVALSLGASFGLSVL
MLBr_02378|M.leprae_Br4923          ANWDLVIAGISSLCLIFIIMLIITRAFVAAAVIVGTVALSLGASFGLSVL
TH_3260|M.thermoresistible__bu      TKYDLIIAAIAAVCLIFIIMLILTRAVVAAAVIVGTVTLSLAASFGVSVL
Mvan_3189|M.vanbaalenii_PYR-1       NNYDLLIAGISALGLIFIIMLILTRAIVAAAVIVGTVVLSLAASFGLSVL
Mflv_4418|M.gilvum_PYR-GCK          AFYDLLIAGIAAVTLIFVIMLVITRSVVAAAVIVGTVLLSLGASFGLSVL
Mb1583|M.bovis_AF2122/97            ATYDLLIAGIAALSLILLIMMIITRSLVAALVIVGTVALSLGASFGLSVL
MAB_0987c|M.abscessus_ATCC_199      QKYDLLMAALASLGLILLIMMFLTRSLVAALVIVGTVALSLAASFGMSVV
MMAR_3744|M.marinum_M               EKYDLMIAVVSALTLIFLIMLLLTRSVVAALVIVGTAASSIAASFGLSVL
MUL_3688|M.ulcerans_Agy99           EKYDLMIAVVSALTLIFLIMLLLTRSVVAALVIVGTAASSIAASFGLSVL
MAV_1755|M.avium_104                EKYDLMIAVVSALTLIFMIMLLLTRSVVAALVIVGTAASSIAASFGLSVL
MSMEG_0576|M.smegmatis_MC2_155      ARYDLMIAVVSALTLIFMIMLILTRSAVAALVIVGTAASSIAASFGISVL
                                      :**::* :::: **::**:.:**: :** *****.  *:.****:**:

Rv0450c|M.tuberculosis_H37Rv        LWQHILAIHLHWLVLAMSVIVLLAVGSDYNLLLVSRFKQEIGAGLKTGII
MLBr_02378|M.leprae_Br4923          LWQHILGIELHYLVLAMSVIVLLAVGSDYNLLLVSRFKQEIQAGLKTGII
TH_3260|M.thermoresistible__bu      IWQYIVGLEMHWMVFPMALIILLAVGADYNLLVVARLREEIPAGLNTGMI
Mvan_3189|M.vanbaalenii_PYR-1       FWQHILGTELHWMVLAMAVIVLLAVGADYNLLLVSRLKEEIHAGIGTGII
Mflv_4418|M.gilvum_PYR-GCK          LWQHIIGLALHWMVLPMAVILLLAVGSDYNLLLVSRFKEELSGGLKTGII
Mb1583|M.bovis_AF2122/97            VWQHLLGIQLYWIVLALAVILLLAVGSDYNLLLISRFKEEIGAGLNTGII
MAB_0987c|M.abscessus_ATCC_199      VWQYIFGIPLYWVIFPLAVIILLAVGADYNLLLISRFKEETGAGLKTGII
MMAR_3744|M.marinum_M               IWQDLFGIKIHWIVAALSVIILLAVGSDYNLLLVSRFREEIHAGLKTGII
MUL_3688|M.ulcerans_Agy99           IWQDLFGIKIHWIVAALSVIILLAVGSDYNLLLVSRFREEIHAGLKTGII
MAV_1755|M.avium_104                IWQDLFGIRIHWIVAALSVIILLAVGSDYNLLLVSRFREEIHGGLKTGII
MSMEG_0576|M.smegmatis_MC2_155      LWQDLFGVEVHWLVMLMSVIILLAVGSDYNLLLVSRFKDEIHAGLKTGII
                                    .** :..  :::::  :::*:*****:*****:::*:::*  .*: **:*

Rv0450c|M.tuberculosis_H37Rv        RSMGGTGKVVTNAGLVFAVTMASMAVSDLRVIGQVGTTIGLGLLFDTLIV
MLBr_02378|M.leprae_Br4923          RSMGGTGKVVTNAGLVFAFTMASMVVSDLRVIGQVGTTIGLGLLFDTLIV
TH_3260|M.thermoresistible__bu      RAMGGSGSVVTAAGLVFGLTMMVMVVSDLTVMGQVGTTIGLGLLFDTFVV
Mvan_3189|M.vanbaalenii_PYR-1       RAMGGSGSVVTAAGLVFALTMMSMAVSELTVIGQVGTTIGLGLLFDTLVI
Mflv_4418|M.gilvum_PYR-GCK          RAMAGTGSVVTSAGLVFAFTMASFAFSDLKVMAQVGTTIALGLLFDTLIV
Mb1583|M.bovis_AF2122/97            RAMAGTGGVVTAAGLVFAATMSSFVFSDLRVLGQIGTTIGLGLLFDTLVV
MAB_0987c|M.abscessus_ATCC_199      RAIAGTGGVVTAAGLVFAVTMSSFVFSDLRVLGQIGTTIGLGLLFDTLVV
MMAR_3744|M.marinum_M               RSMAGTGGVVTAAGLVFAFTMASMLGSDLRVLGQFGSTVCIGLLLDTLIV
MUL_3688|M.ulcerans_Agy99           RSMAGTGGVVTAAGLVFAFTMASMLGSDLRVLGQFGSTVCIGLLLDTLIV
MAV_1755|M.avium_104                RSMAGTGGVVTAAGLVFAFTMAAMLGSELRVLGQFGSTVCIGLLLDTLIV
MSMEG_0576|M.smegmatis_MC2_155      RSMAGTGGVVTSAGLVFAATMAAMLGSELVVLAQMGSTIAIGLLLDTLIV
                                    *::.*:* *** *****. **  :  *:* *:.*.*:*: :***:**:::

Rv0450c|M.tuberculosis_H37Rv        RSFMTPSIAALLGRWFWWPLRVRSRPAR---TPTVPSET--------QPA
MLBr_02378|M.leprae_Br4923          RSFMMPSIAALLGRWFWWPQQGRTRPLL---TVAAPVGL--------PPD
TH_3260|M.thermoresistible__bu      RSFMMPSIATLLGRWFWWPQFVRKRPVP---QPWPSVPP--------RGP
Mvan_3189|M.vanbaalenii_PYR-1       RAFMTPSIAALLGPWFWWPQRVRTRPVP---APWPRPGG--------LQS
Mflv_4418|M.gilvum_PYR-GCK          RSFMTPAVAALLGRWFWWPQKFRSAASE---RRLARIG---------VQP
Mb1583|M.bovis_AF2122/97            RAFMTPSIAVLLGRWFWWPQRVRPRPASRMLRPYGPRPVVRELLLREGND
MAB_0987c|M.abscessus_ATCC_199      RSFLTPAIATMLGRWFWWPINIRTRPAP---KPFGPKP--------TGAD
MMAR_3744|M.marinum_M               RTLLMPSIATLLGRWFWWPQVVHPRGDNARPRVAAPTH------------
MUL_3688|M.ulcerans_Agy99           RTLLMPSIATLLGRWFWWPQVVHPRGDNARPRVAAPTH------------
MAV_1755|M.avium_104                RTLLMPSIATLLGRWFWWPMVVHPRGDNARRPVPASS-------------
MSMEG_0576|M.smegmatis_MC2_155      RSLLMPSIATLLGRWFWWPQVVYPRGDNHFRRPTAVSRG--------TGD
                                    *::: *::*.:** *****                               

Rv0450c|M.tuberculosis_H37Rv        GRPLAMSSDRLG
MLBr_02378|M.leprae_Br4923          -RSLVYSD----
TH_3260|M.thermoresistible__bu      ATTDRVSV----
Mvan_3189|M.vanbaalenii_PYR-1       DPSEGVKV----
Mflv_4418|M.gilvum_PYR-GCK          ATAGR-------
Mb1583|M.bovis_AF2122/97            DPRTQVATHR--
MAB_0987c|M.abscessus_ATCC_199      DTTGPIPVSG--
MMAR_3744|M.marinum_M               ------------
MUL_3688|M.ulcerans_Agy99           ------------
MAV_1755|M.avium_104                ------------
MSMEG_0576|M.smegmatis_MC2_155      EDTAALPVPS--