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MIQGLHNRSDSRPLLPHALRVLAIPVILFWVAFAAVVNIIAPQLEIVGEEHSAPMAPEDAPSLTGMHRMG GNFQEFDSNSTVMVVIEGQEPLGPDAHAYYDEIIRKLRQDPEHIQHIQDFWGDTLTAAGAQSADGKAAYV MLNLAGEQGQTLANDGVQEVRQVIADTPAPPGVQAYAAGPAALTDDLHVIGNASLGKITLFTLVAIAVML LIVYRSIVTTLIQLVLTGVGLLASRGLISVLATHDVFGLTTFAGNILTMLAIAAATDYGIFLFGRYREAR GAGEDPETAYYTTFKSVSPVIVGSGLTIAGATYCLSFARLPYFSTMGAPVAIGMIVVVASSVTMGPAVLF LGSKVGLYEAKRAAKGRFWRRVGTAVVRWPAPILVASAFIVLIGVVAVPGYRPAYNDRWYLPDDAPVNIG FAAADRHFTQARMNPDILMVEADHDMRNPADMLVLDRVAKNVLRTQGIAMVQSITRPLGIPIQHSSIPFQ TAIQGQTSNLNLPFQRAQLDNQLKMVEATNQSIAIMEKQYELSLRQTKLTQDSAEKSRELLEVTKQLRDN IANFDDQFRPLRNYFYWEPHCFDIPMCAAARSLFDSLDTVDELTDRTSAVQVNTDELADLAPQLTALLPQ TIASMKTSRDLSLASYNSQKALLDQMQAMNDTALAMGQSFDEAKNDDFFYLPPEAFQNPDFERGLKMFLS PDGKSARMFITHQSDPATPEGIARVNAERTAAQEGLKMSSLSDAKIFLGGTAATYKDMSDGARYDLMIAV VSALTLIFMIMLILTRSAVAALVIVGTAASSIAASFGISVLLWQDLFGVEVHWLVMLMSVIILLAVGSDY NLLLVSRFKDEIHAGLKTGIIRSMAGTGGVVTSAGLVFAATMAAMLGSELVVLAQMGSTIAIGLLLDTLI VRSLLMPSIATLLGRWFWWPQVVYPRGDNHFRRPTAVSRGTGDEDTAALPVPS
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_0576 | - | - | 100% (963) | MmpL4 protein |
M. smegmatis MC2 155 | MSMEG_3496 | - | 0.0 | 55.06% (919) | MmpL4 protein |
M. smegmatis MC2 155 | MSMEG_0382 | - | 0.0 | 55.13% (936) | putative transport protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1583 | mmpL6 | 0.0 | 54.79% (940) | transmembrane transport protein MmpL6 |
M. gilvum PYR-GCK | Mflv_4418 | - | 0.0 | 54.87% (913) | transport protein |
M. tuberculosis H37Rv | Rv0450c | mmpL4 | 0.0 | 54.84% (930) | transmembrane transport protein MmpL4 |
M. leprae Br4923 | MLBr_02378 | - | 0.0 | 53.86% (919) | hypothetical protein MLBr_02378 |
M. abscessus ATCC 19977 | MAB_0987c | - | 0.0 | 53.66% (943) | membrane protein MmpL |
M. marinum M | MMAR_3744 | mmpL4_1 | 0.0 | 69.43% (929) | transmembrane transport protein MmpL4_1 |
M. avium 104 | MAV_1755 | - | 0.0 | 68.73% (937) | MmpL4 protein |
M. thermoresistible (build 8) | TH_3260 | - | 0.0 | 52.44% (921) | PUTATIVE MmpL4 protein |
M. ulcerans Agy99 | MUL_3688 | mmpL4_1 | 0.0 | 69.11% (929) | transmembrane transport protein MmpL4_1 |
M. vanbaalenii PYR-1 | Mvan_3189 | - | 0.0 | 54.62% (930) | transport protein |
CLUSTAL 2.0.9 multiple sequence alignment Rv0450c|M.tuberculosis_H37Rv -------------------MSTKFANDSNTNARPEK----------PFIA MLBr_02378|M.leprae_Br4923 -------------------MTVKCANDLDTHTKP------------PFVA TH_3260|M.thermoresistible__bu -------------------MTANPGHVRTDEAPTDRLDIKVSTHGPSFIS Mvan_3189|M.vanbaalenii_PYR-1 -------------------MSAPVSDARTDEFPAAR-----QPHRP-FIP Mflv_4418|M.gilvum_PYR-GCK --------------------MADAGRSG--------------------IG Mb1583|M.bovis_AF2122/97 -------------------MSNHHRPRP-------------------WLP MAB_0987c|M.abscessus_ATCC_199 -------------------MSANHAHES-------------------RAA MMAR_3744|M.marinum_M MSESN--SGASISTEDTGPIEIGAATGGAPNRERGH---------RPVIP MUL_3688|M.ulcerans_Agy99 MSESN--SGASISTEDTGPIEIGAATGGAPNRERGH---------RPVIP MAV_1755|M.avium_104 MSDASNKTQPDLSAADTGPINVKGLS----KAERGH---------RPYLP MSMEG_0576|M.smegmatis_MC2_155 --------------------MIQGLH-----NRSDS---------RPLLP Rv0450c|M.tuberculosis_H37Rv RMIHAFAVPIILGWLAVCVVVTVFVPSLEAVGQERSVSLSPKDAPSFEAM MLBr_02378|M.leprae_Br4923 RMIHRFAVPIILVWLAIAVTVSVFIPSLEDVGQERSVSLSPKDAPSYIAM TH_3260|M.thermoresistible__bu TWIRRLSLPIIVGWIALIALLNITVPQLEVVGEMRAVSMSPDEAPSMVAM Mvan_3189|M.vanbaalenii_PYR-1 RMIRLFAVPIILGWIALIVILNVTVPQLEAVGEARAVSMSPNEAPSLISM Mflv_4418|M.gilvum_PYR-GCK RIIRVLAVPIVLGWVLLTVLTNVAVPSLEKVGEEHTVGMSAGDAPSMMSM Mb1583|M.bovis_AF2122/97 HTIRRLSLPILLFWVGVAAITNAAVPQLEVVGEAHNVAQSSPDDPSLQAM MAB_0987c|M.abscessus_ATCC_199 KIVRRLAVPIVLFWVAIAAVTNATVPQLEVVGEERSAPLNAADAPSTLAM MMAR_3744|M.marinum_M HTIRILAVPIILGWVLLTVLVNVVVPSLEVVSEQHSAPMTPMDAPSMKAM MUL_3688|M.ulcerans_Agy99 HTIRILAVPIILGWVLLTVLVNVVVPSLEVVSEQHSAPMTPMDAPSMKAM MAV_1755|M.avium_104 HAIRIFAVPIILGWLFVTVLVNVIVPTLEKVGEAHSAPMTPLDAPSMKAM MSMEG_0576|M.smegmatis_MC2_155 HALRVLAIPVILFWVAFAAVVNIIAPQLEIVGEEHSAPMAPEDAPSLTGM :: :::*::: *: . . . * ** *.: : . . : ** .* Rv0450c|M.tuberculosis_H37Rv GRIGMVFKEGDSDSFAMVIIEGNQPLGDAAHKYYDGLVAQLRADKKHVQS MLBr_02378|M.leprae_Br4923 QKMGQVFNEGNSDSVIMIVLEGDKPLGDDAHRFYDGLIRKLRADK-HVQS TH_3260|M.thermoresistible__bu KRVGELFDEGSSDSQVMIVLEGEEPLGADARAFYDELVKRLEADDAHVEN Mvan_3189|M.vanbaalenii_PYR-1 KKVGELFREGDSDSSVMIVFEGDQPLGDEAHAWYDELVERLRADTKHVQS Mflv_4418|M.gilvum_PYR-GCK KRVGANFEEFDSDSSAMVVLEGEQPLGDAAHRYYDQLIDELEADTANVQH Mb1583|M.bovis_AF2122/97 KRIGKVFHEFDSDSAAMIVLEGDKPLGNDAHRFYDTLLRNLSNDTKHVEH MAB_0987c|M.abscessus_ATCC_199 RHIGKVFNEFDSDSSAMVVLEGEKPLGAQAHQFYNTLVQRLNDDHEHVQH MMAR_3744|M.marinum_M MRLGHNFREFDSNSTVMIVLEGQHKLGDDAHQYYDSLIRQLRQDPEHIQH MUL_3688|M.ulcerans_Agy99 MRLGHNFREFDSNSTVMIVLEGQHKLGDDAHQYYDSLIRQLRQDPEHIQH MAV_1755|M.avium_104 MRLGHNFHEFDSNSTVMIVLEGQQPLGPDAHKYYDNLIRQLRQDPKHIQH MSMEG_0576|M.smegmatis_MC2_155 HRMGGNFQEFDSNSTVMVVIEGQEPLGPDAHAYYDEIIRKLRQDPEHIQH ::* * * .*:* *:::**:. ** *: :*: :: .* * ::: Rv0450c|M.tuberculosis_H37Rv VQDLWGDPLTAAGVQSNDGKAAYVQLSLAGNQGTPLANESVEAVRSIVES MLBr_02378|M.leprae_Br4923 VQDFWGDPLTAPGAQSNDGKAAYVQLSLAGNQGELLAQESIDAVRKIVVQ TH_3260|M.thermoresistible__bu VQDLWSDPLTATGVQSPDGKSAYVQVKLAGNQGEALANESVETVREMIAT Mvan_3189|M.vanbaalenii_PYR-1 VQDFWSDPLTASGSQSNDGKAAYVQVKLAGNQGESLANESVQAAQEIVRS Mflv_4418|M.gilvum_PYR-GCK IADFWGDPLTASGAQSTDGKAAYVQVYLQGNQGEPRANEAVAAVREIVDR Mb1583|M.bovis_AF2122/97 VQDFWGDPLTAAGSQSTDGKAAYVQVYLAGNQGEALSIESVDAVRDIVAH MAB_0987c|M.abscessus_ATCC_199 VADYWGDPITAGGSQSKDGKAAYVQVYVAGNQGEALSNESVDAVRRIIAE MMAR_3744|M.marinum_M IQDFWGDRLTAAGAQSADGKSAYVMVNLAGNQGTTLANESVEAVRDVINR MUL_3688|M.ulcerans_Agy99 IQDFWGDRLTAAGAQSADGKSAYVMVNLAGNQGTTLANESVEAVRDVINR MAV_1755|M.avium_104 IQDFWGDRLTAAGAQSADAKGAYVQVNLAGNQGTTLANESVDAVRKVIDE MSMEG_0576|M.smegmatis_MC2_155 IQDFWGDTLTAAGAQSADGKAAYVMLNLAGEQGQTLANDGVQEVRQVIAD : * *.* :** * ** *.*.*** : : *:** : :.: .: :: Rv0450c|M.tuberculosis_H37Rv TP---APPGIKAYVTGPSALAADMHHSGDRSMARITMVTVAVIFIMLLLV MLBr_02378|M.leprae_Br4923 TP---APPGITAWVTGASALIADMHHSGDKSMIRITATSVIVILVTLLLV TH_3260|M.thermoresistible__bu VSEEMAPEGVQAFVTGGAAMSADQQEAGDSSLRVIEALTFLVITTMLLFV Mvan_3189|M.vanbaalenii_PYR-1 LE---PPPGVRAFVTGPAALAADQHIASDRSVRVIELVTFAVIIVMLLLV Mflv_4418|M.gilvum_PYR-GCK TP---APPGIKAYVTGGAPLVADQHSAGDTSVLRVTLITIGVIAVMLLIV Mb1583|M.bovis_AF2122/97 TP---PPAGVKAYVTGAAPLMADQFQVGSKGTAKVTGITLVVIAVMLLFV MAB_0987c|M.abscessus_ATCC_199 TP---APDGIKAYVSGEAPTITDQFEVGNAGAAQVTIITFAVIAVMLLVV MMAR_3744|M.marinum_M TH---EPAGVKAYVTGPAALSDDMHLIGNASLAKITMFTLGAIAVMLLLV MUL_3688|M.ulcerans_Agy99 TH---EPAGVKAYVTGPAALSDDMHLIGNASLATITMFTLGAIAVMLLLV MAV_1755|M.avium_104 NK---APPGVKAYVTGPAALSDDMHIIGNASLAKITLFTLGAIAIMLLLV MSMEG_0576|M.smegmatis_MC2_155 TP---APPGVQAYAAGPAALTDDLHVIGNASLGKITLFTLVAIAVMLLIV * *: *:.:* :. * .. . : :. .* **.* Rv0450c|M.tuberculosis_H37Rv YRSIITVVLLLITVGVELTAARGVVAVLGHSGAIGLTTFAVSLLTSLAIA MLBr_02378|M.leprae_Br4923 YRSFITVILLLFTVGIESAVARGVVALLGHTGLIGLSTFAVNLLTSLAIA TH_3260|M.thermoresistible__bu YRSVITVLIALFMVLIGLLTTRGVVAFLGYHNIIGLSTFATSLLVTLAIA Mvan_3189|M.vanbaalenii_PYR-1 YRSIVTVLLTLVMVVLSLATARGVVAFLGWHEIIGLSLFATNLLVTLAIA Mflv_4418|M.gilvum_PYR-GCK FRSVATMVLILFMVFAELGAARGIVAFLADAEIIGLSTFATSLLTLMVIA Mb1583|M.bovis_AF2122/97 YRSVVTMVLVLITVLIELAAARGIVAFLGNAGVIGLSTYSTNLLTLLVIA MAB_0987c|M.abscessus_ATCC_199 YRSLITTALVLAMVMVELSAARGIVAALGHTGVIGLSTYATNLLTMLAIA MMAR_3744|M.marinum_M YRSIVTTVIQLFMTGIALASSRGVVAVLGYHNVFGLTTFAANILTMLAIA MUL_3688|M.ulcerans_Agy99 YRSIVTTVIQLFMTGIALASSRGVVAVLGYHNVFGLTTFAANILTMLAIA MAV_1755|M.avium_104 YRSIVTTLVQLFMTFVALACSRGVVAVLAYHNAFGLTTFAANILTMLAIA MSMEG_0576|M.smegmatis_MC2_155 YRSIVTTLIQLVLTGVGLLASRGLISVLATHDVFGLTTFAGNILTMLAIA :**. * : * . :**::: *. :**: :: .:*. :.** Rv0450c|M.tuberculosis_H37Rv AGTDYGIFIIGRYQEARQAGEDKEAAYYTMYRGTAHVILGSGLTIAGATF MLBr_02378|M.leprae_Br4923 AGTDYGIFITGRYQEARQANENKEAAFYTMYRGTFHVILGSGLTISGATF TH_3260|M.thermoresistible__bu IAVDYAIFLIGRYQEARSVGADRATAYHTMFGGTAHVILASGLTIAGATF Mvan_3189|M.vanbaalenii_PYR-1 AATDYAIFLIGRYQEARTNGEDKESAYYTMFHGTAHVVLGSGLTIAGATY Mflv_4418|M.gilvum_PYR-GCK AGTDYAIFAIGRYQEARGAGEDRETAYYTMFRGTAHVVLGSGLTIAGAML Mb1583|M.bovis_AF2122/97 AGTDYAIFVLGRYHEARYAAQDRETAFYTMYRGTAHVVLGSGLTVAGAVY MAB_0987c|M.abscessus_ATCC_199 AGTDYAIFFVGRYQEARSAGEDRPSAYQTMYKSTAHVIIGSGLTVAGALF MMAR_3744|M.marinum_M AGTDYGIFLVGRYQEARQAGEDREDAYYTTFRGVAPVVLGSGLTIAGATY MUL_3688|M.ulcerans_Agy99 AGTDYGIFLVGRYQEARQAGEDRQDAYYTTFRGVAPVVLGSGLTIAGATY MAV_1755|M.avium_104 AGTDYGIFLIGRYQEALAAGEDRESAYYTTFKGVAPVVLGSGLTIAGATY MSMEG_0576|M.smegmatis_MC2_155 AATDYGIFLFGRYREARGAGEDPETAYYTTFKSVSPVIVGSGLTIAGATY ..**.** ***:** : *: * : .. *::.****::** Rv0450c|M.tuberculosis_H37Rv CLSFARMPYFQTLGIPCAVGMLVAVAVALTLGPAVLHVGSRFG-LFDPKR MLBr_02378|M.leprae_Br4923 CLSFARMPYFQTLGVPCAVGMLIAVAVALTLGPAVLTVGSRFG-LFEPKR TH_3260|M.thermoresistible__bu CLSFTRLPYFQSLGPPLAIGMIVLIVTSLTMGPAIITVATRFG-LLEPKR Mvan_3189|M.vanbaalenii_PYR-1 CLSFTRLPYFQTLGVPLAIGMFVVVMAGVILMVAMISVATRFGKLLEPKR Mflv_4418|M.gilvum_PYR-GCK CLSFTRLPYFQTMGVPCAVGTFVAVIAALTLGPAVIVIGSRFG-LFDPKR Mb1583|M.bovis_AF2122/97 CLSFTRLPYFQSLGIPASIGVMIALAAALSLAPSVLILGSRFG-CFEPKR MAB_0987c|M.abscessus_ATCC_199 CLSFTRLPYFQTLGVPAALGVLVTLAAALTLAPAVLVIAGRFG-LMEPKR MMAR_3744|M.marinum_M CLSFARLPWFNTMGAPVAIGMLVVVLAGLTLGPAVVFVGSRFH-LFESKR MUL_3688|M.ulcerans_Agy99 CLSFARLPWFNTMGAPVAIGMLVVVLAGLTLGPAVVFVGSRFH-PFESKR MAV_1755|M.avium_104 CLSFSRLPWFNTMGAPVAIGMLVVVLAGVTLGPAVVFVGSRFH-FFE--R MSMEG_0576|M.smegmatis_MC2_155 CLSFARLPYFSTMGAPVAIGMIVVVASSVTMGPAVLFLGSKVG-LYEAKR ****:*:*:*.::* * ::* :: : .: : ::: :. :. : * Rv0450c|M.tuberculosis_H37Rv LLK-VRGWRRVGTVVVRWPLPVLVATCAIALVGLLALPGYKTSYNDRDYL MLBr_02378|M.leprae_Br4923 LIK-VRGWRRIGTVVVRWPLPILITTCAIAMVGLLALPGYRTNYKDRAYL TH_3260|M.thermoresistible__bu AAR-VRFWRKVGASVVRWPGPIMVTTVAVTLVGLLALPGYRTNYNDRNYL Mvan_3189|M.vanbaalenii_PYR-1 AMR-IRGWRKIGAAVVRWPGPILVATLAITLVGLLALPGYKTNYNDRTYL Mflv_4418|M.gilvum_PYR-GCK AIS-SRGWRRIGVSVVRWPGPVLAATLALALVGLVTLPGYKTNYDARDYL Mb1583|M.bovis_AF2122/97 RMR-TRGWRRIGTAIVRWPGPILAVACAIAVVGLLALPGYKTSYDARYYM MAB_0987c|M.abscessus_ATCC_199 AMR-TRGWRRIGTAIVRWPGPILVVSCIATLVGLLALPGYRTTYDGRIYM MMAR_3744|M.marinum_M AANRGRLWRRVGTAVVRWPAPILALSGAIVLVGMVALPGFKTSYNDRYYL MUL_3688|M.ulcerans_Agy99 AANRGRLWRRVGTAVVRWPAPILALSGAIVLVGMVALPGFKTSYNDRYYL MAV_1755|M.avium_104 QAKRGRLWRRVGTAVVRWPAPVLAVSAAVVLVGMIALPSFHTSYNDRHYL MSMEG_0576|M.smegmatis_MC2_155 AAK-GRFWRRVGTAVVRWPAPILVASAFIVLIGVVAVPGYRPAYNDRWYL * **::*. :**** *:: : .::*::::*.::. *. * *: Rv0450c|M.tuberculosis_H37Rv PDFIPANQGYAAADRHFSQARMKPEILMIESDHDMRNPADFLVLDKLAKG MLBr_02378|M.leprae_Br4923 PASIPANQGFAAADRHFPQARMKPEILMIESDHDMRNPADFLILDKLARG TH_3260|M.thermoresistible__bu PASFPSNAGYEAAERHFDPARLNPELLLIESDHDLRNPADFLVIEKIAKA Mvan_3189|M.vanbaalenii_PYR-1 PADLPANEGYAVADRHFDQARMNPELLMIESDHDLRNSADFLVIDKIAKA Mflv_4418|M.gilvum_PYR-GCK PEDIPANVGYAVADQHFGSARMNPELLMVESDHDLRNPADFLVIDKIAKS Mb1583|M.bovis_AF2122/97 PATAPANIGYMAAERHFPQARLNPELLMIETDHDMRNPADMLILDRIAKA MAB_0987c|M.abscessus_ATCC_199 PSSVPSNVGYAAAERHFSVARLNPELLMIETDFDMRNPAGMVLLERVAKS MMAR_3744|M.marinum_M PASAPSNLGEAAADRHFSHARMNPDMLMVEAEHDMRNPADMLVLDKVAKN MUL_3688|M.ulcerans_Agy99 PASAPSNLGEAAADRHFSHARMNPDMLMVEAEHDMRNPADMLVLDKVAKN MAV_1755|M.avium_104 PLSAPSNQGQEAANRHFSEARMNPDLLMIESDHDMRNPADMLVLDRVAKN MSMEG_0576|M.smegmatis_MC2_155 PDDAPVNIGFAAADRHFTQARMNPDILMVEADHDMRNPADMLVLDRVAKN * * * * .*::** **::*::*::*::.*:**.*.:::::::*: Rv0450c|M.tuberculosis_H37Rv IFRVPGISRVQAITRPEGTTMDHTSIPFQISMQNAGQLQTIKYQRDRAND MLBr_02378|M.leprae_Br4923 IFRVPGISRVQAITRPDGTAMDHTSIPFQISMQNAGQVQTMKYQKDRMND TH_3260|M.thermoresistible__bu VFQVEGISRVQGITRPEGTPIEHSSIPFMISQQGTLQILNQQYMQDRMAD Mvan_3189|M.vanbaalenii_PYR-1 IFKVEGIARVQAITRPDGKPIKHTSIPFQMSMQGTTQRLNEKYMQDRMAD Mflv_4418|M.gilvum_PYR-GCK VFRVPGVARVQTITRPDGKPIKHTTIPFQMSMQGTTQRLNEKYLQDRMAD Mb1583|M.bovis_AF2122/97 VFHLPGIGLVQAMTRPLGTPIDHSSIPFQISMQSVGQIQNLKYQRDRAAD MAB_0987c|M.abscessus_ATCC_199 VLHARGVALVQSITRPLGTPITHSSIPFQISASSASQLMNLSQQQNQALY MMAR_3744|M.marinum_M VIRTVGIAMIQDITRPLGIPIQHSSIPFQNSMQSQTMMQNMAFLKERMAD MUL_3688|M.ulcerans_Agy99 VIRTVGIAMIQDITRPLGIPIQHSSIPFQNSMQSQTMMQNMAFLKERMAD MAV_1755|M.avium_104 EMRTLGIAMVQDITRPLGIPIQHSSIPFQNSVQSQTTMQNMGFLKERMND MSMEG_0576|M.smegmatis_MC2_155 VLRTQGIAMVQSITRPLGIPIQHSSIPFQTAIQGQTSNLNLPFQRAQLDN :: *:. :* :*** * .: *::*** : .. . : : Rv0450c|M.tuberculosis_H37Rv MLKQADEMATTIAVLTRMHSLMAEMASTTHRMVGDTEEMKEITEELRDHV MLBr_02378|M.leprae_Br4923 LLRQAENMAETIASMRRMHQLMALLTENTHHILNDTVEMQKTTSKLRDEI TH_3260|M.thermoresistible__bu MLVQADEMQLMIDTMDKMIALMEEMVETTDNMVRDMDEMAAHVAEMRDSI Mvan_3189|M.vanbaalenii_PYR-1 MLVQADEMANTIATMEKMSNLTAQMADITHSMVSKMENMLTDIEDLRDSI Mflv_4418|M.gilvum_PYR-GCK MLVQADAMQTNVDTMTRMQSLMGQMSATTHEMVLKTKKTEIDIIEVRDNL Mb1583|M.bovis_AF2122/97 LLKQAEELGKTIEILQRQYALQQELAAATHEQAESFHQTIATVKELRDRI MAB_0987c|M.abscessus_ATCC_199 LSQQADQMTNTIAVLRQQLALQKQSAAITHEQTEGFQQTVAVAQDLRDKI MMAR_3744|M.marinum_M MTKMADEMQVLIDTTERMYAVMRDLDTTTTDMARVTAETSTITDELRDHL MUL_3688|M.ulcerans_Agy99 MTKMADEMQVLIDTTERMYAVMRELDTTTTDMARVTAETSTITDELRDHL MAV_1755|M.avium_104 ILKMADDLQTQIDTTQRQYEVSMDLANAADDSAKTTAVTSQITDSLRDHI MSMEG_0576|M.smegmatis_MC2_155 QLKMVEATNQSIAIMEKQYELSLRQTKLTQDSAEKSRELLEVTKQLRDNI .: : : : : .:** : Rv0450c|M.tuberculosis_H37Rv ADFDDFWRPIRSYFYWEKHCYGIPICWSFRSIFDALDGIDKLSEQIGVLL MLBr_02378|M.leprae_Br4923 ANFDDFWRPIRSYFYWERHCFNIPICWSFRSIFDALDGVDQIDERLNSIV TH_3260|M.thermoresistible__bu SEFDDFFRPIRNYFYWEPHCYNIPVCWAMRSVFDTLDGINTMTDDIQNML Mvan_3189|M.vanbaalenii_PYR-1 ANFDDFFRPIRNYFYWEPHCYNIPVCWALRSVFDTLDGINVMTDDFREIL Mflv_4418|M.gilvum_PYR-GCK ADFDDFFRPVRNYFYWEPHCYDIPVCWTMRSVFDTLDGINPLTDDISELI Mb1583|M.bovis_AF2122/97 ANFDDFFRPIRSYFYWEKHCYDIPSCWALRSVFDTIDGIDQLGEQLASVT MAB_0987c|M.abscessus_ATCC_199 ANFDDQFRPIRNYFYWEPHCFDIPFCAALRSVFDALDGIDELVDALQSVT MMAR_3744|M.marinum_M AEFDDFWRPMRSYFYWEKHCFDVPICWSFRSLFDSLDGIDKLSEKFSELT MUL_3688|M.ulcerans_Agy99 AEFDDFWRPMRSYFYWEKHCFDVPICWSFRSLFDSLDGIDKLSEKFSELT MAV_1755|M.avium_104 ADFDDTFRPIRTYFYWEKHCYDIPVCIGLRSLFDTFDGFDQLAEQFHYLT MSMEG_0576|M.smegmatis_MC2_155 ANFDDQFRPLRNYFYWEPHCFDIPMCAAARSLFDSLDTVDELTDRTSAVQ ::*** :**:*.***** **:.:* * **:**::* .: : : : Rv0450c|M.tuberculosis_H37Rv GDLREMDRLMPQMVAQIPPQIEAMENMRTMILTMHSTMTGIFDQMLEMSD MLBr_02378|M.leprae_Br4923 GDIKNMDLLMPQMLEQFPPMIESMESMRTIMLTMHSTMSGIFDQMNELSD TH_3260|M.thermoresistible__bu PHMHRLNDLMPQMLTLLPTTVATMKTMRSMLLTMQATNAGLQDQMAEMQE Mvan_3189|M.vanbaalenii_PYR-1 PDMKRLDSLMPQMVALMPEMIETMKTMRTMMLTMYQSQKGQQDQMAAMSE Mflv_4418|M.gilvum_PYR-GCK PDLERLDELMPQLIALLPSQIETMRSMQAMMLRQYQTQKGQLDQNAAMSE Mb1583|M.bovis_AF2122/97 VTLDKLAAIQPQLVALLPDEIASQQINRELALANYATMSGIYAQTAALIE MAB_0987c|M.abscessus_ATCC_199 GSLTKLDALQPKLVDLIPPQIAIQEKNRDLTLSNYAINNGTNTQNEESTR MMAR_3744|M.marinum_M EDIQHTAGLTSQMLTLIPPMIATMKTTKALTLTMQSTFSAMLDQMDELSN MUL_3688|M.ulcerans_Agy99 EDIQRTAGLTSQMLTLIPPMIATMKTTKALTLTMQSTFSAMLDQMDELSN MAV_1755|M.avium_104 TDIAHTAKASRDLTALFPTLITTLKTTRGITLTLYQTFKAMIDQMEAMSN MSMEG_0576|M.smegmatis_MC2_155 VNTDELADLAPQLTALLPQTIASMKTSRDLSLASYNSQKALLDQMQAMND . .: :* : . : : * . * Rv0450c|M.tuberculosis_H37Rv NATAMGKAFDAAKNDDSFYLPPEVFKNKDFQRAMKSFLSSDGHAARFIIL MLBr_02378|M.leprae_Br4923 NANTMGKAFDTAKNDDSFYLPPEVFKNTDFKRAMKSFLSSDGHAARFIIL TH_3260|M.thermoresistible__bu NANAMGEAFDQARNDDSFYLPPEAFDNPDFQRGLEQFLSPDGHAVRFIIS Mvan_3189|M.vanbaalenii_PYR-1 DADAMGEAFDDSMNDDSFYLPPEIFENKDFQRGLEQFLSPDGHAVRFIIS Mflv_4418|M.gilvum_PYR-GCK DADAMGEAFDDSMNDDSFYLPPEAFDNDDFKRGMENFISPDGRSVRFIIS Mb1583|M.bovis_AF2122/97 NAAAMGQAFDAAKNDDSFYLPPEAFDNPDFQRGLKLFLSADGKAARMIIS MAB_0987c|M.abscessus_ATCC_199 TATELGKAFDDAKNDDSFYLPPEAFDNPAFKRGMKLFMSPDGKAARMIIT MMAR_3744|M.marinum_M TAIVMGQSFDASKNDDFFYLPPEAFDNPDFQTGLRMFLSPDGKSARFFIT MUL_3688|M.ulcerans_Agy99 TAIVMGQSFDASKNDDFFYLPPEAFDNPDFQTGLRMFLSPDGKSARFFIT MAV_1755|M.avium_104 TAVVMGQSFDASKNDDFFYLPPEAFDNPDFQTGLRMFLSPDGKSARFFIT MSMEG_0576|M.smegmatis_MC2_155 TALAMGQSFDEAKNDDFFYLPPEAFQNPDFERGLKMFLSPDGKSARMFIT * :*::** : *** ****** *.* *: .:. *:*.**::.*::* Rv0450c|M.tuberculosis_H37Rv HRGDPQSPEGIKSIDAIRTAAEESLKGTPLEDAKIYLAGTAAVFHDISEG MLBr_02378|M.leprae_Br4923 HRGDPASVAGIASINAIRTAAEEALKGTPLEDTKIYLAGTAAVFKDIDEG TH_3260|M.thermoresistible__bu HQGDPMTPEGLAKIEPIKKAAVEAIKGTPLEGSRVYLGGTAAVFKDMSDG Mvan_3189|M.vanbaalenii_PYR-1 HEGDPLSPEGVAKIDKIKTAAKEAIKGTPLEGSKIYLGGTAATFKDMQDG Mflv_4418|M.gilvum_PYR-GCK HEGDPATVEGISEVVPIKTAAKEAIKGTPLEGSTVYLAGTAATYKDMSDG Mb1583|M.bovis_AF2122/97 HEGDPATPEGISHIDAIKQAAHEAVKGTPMAGAGIYLAGTAATFKDIQDG MAB_0987c|M.abscessus_ATCC_199 HQGDPQTSEGIAHIDAIKEAAFDAVKATPLADAKIYVAGTASAYKDIADG MMAR_3744|M.marinum_M HQGDPMTPEGISRVDAERTAAQEGLKQSSLSDAKVYLGGTAATFKDMADG MUL_3688|M.ulcerans_Agy99 HQGDPMTPEGISRVDAERTAAQEGLKQSSLSDAKVYLGGTAATFKDMADG MAV_1755|M.avium_104 HQGDPMSPEGIKRVDAERTAAQEGLKQSSLSDARVYLGGTAATFKDMADG MSMEG_0576|M.smegmatis_MC2_155 HQSDPATPEGIARVNAERTAAQEGLKMSSLSDAKIFLGGTAATYKDMSDG *..** : *: : : ** :.:* :.: .: :::.***:.::*: :* Rv0450c|M.tuberculosis_H37Rv AQWDLLIAAISSLCLIFIIMLIITRAFIAAAVIVGTVALSLGASFGLSVL MLBr_02378|M.leprae_Br4923 ANWDLVIAGISSLCLIFIIMLIITRAFVAAAVIVGTVALSLGASFGLSVL TH_3260|M.thermoresistible__bu TKYDLIIAAIAAVCLIFIIMLILTRAVVAAAVIVGTVTLSLAASFGVSVL Mvan_3189|M.vanbaalenii_PYR-1 NNYDLLIAGISALGLIFIIMLILTRAIVAAAVIVGTVVLSLAASFGLSVL Mflv_4418|M.gilvum_PYR-GCK AFYDLLIAGIAAVTLIFVIMLVITRSVVAAAVIVGTVLLSLGASFGLSVL Mb1583|M.bovis_AF2122/97 ATYDLLIAGIAALSLILLIMMIITRSLVAALVIVGTVALSLGASFGLSVL MAB_0987c|M.abscessus_ATCC_199 QKYDLLMAALASLGLILLIMMFLTRSLVAALVIVGTVALSLAASFGMSVV MMAR_3744|M.marinum_M EKYDLMIAVVSALTLIFLIMLLLTRSVVAALVIVGTAASSIAASFGLSVL MUL_3688|M.ulcerans_Agy99 EKYDLMIAVVSALTLIFLIMLLLTRSVVAALVIVGTAASSIAASFGLSVL MAV_1755|M.avium_104 EKYDLMIAVVSALTLIFMIMLLLTRSVVAALVIVGTAASSIAASFGLSVL MSMEG_0576|M.smegmatis_MC2_155 ARYDLMIAVVSALTLIFMIMLILTRSAVAALVIVGTAASSIAASFGISVL :**::* :::: **::**:.:**: :** *****. *:.****:**: Rv0450c|M.tuberculosis_H37Rv LWQHILAIHLHWLVLAMSVIVLLAVGSDYNLLLVSRFKQEIGAGLKTGII MLBr_02378|M.leprae_Br4923 LWQHILGIELHYLVLAMSVIVLLAVGSDYNLLLVSRFKQEIQAGLKTGII TH_3260|M.thermoresistible__bu IWQYIVGLEMHWMVFPMALIILLAVGADYNLLVVARLREEIPAGLNTGMI Mvan_3189|M.vanbaalenii_PYR-1 FWQHILGTELHWMVLAMAVIVLLAVGADYNLLLVSRLKEEIHAGIGTGII Mflv_4418|M.gilvum_PYR-GCK LWQHIIGLALHWMVLPMAVILLLAVGSDYNLLLVSRFKEELSGGLKTGII Mb1583|M.bovis_AF2122/97 VWQHLLGIQLYWIVLALAVILLLAVGSDYNLLLISRFKEEIGAGLNTGII MAB_0987c|M.abscessus_ATCC_199 VWQYIFGIPLYWVIFPLAVIILLAVGADYNLLLISRFKEETGAGLKTGII MMAR_3744|M.marinum_M IWQDLFGIKIHWIVAALSVIILLAVGSDYNLLLVSRFREEIHAGLKTGII MUL_3688|M.ulcerans_Agy99 IWQDLFGIKIHWIVAALSVIILLAVGSDYNLLLVSRFREEIHAGLKTGII MAV_1755|M.avium_104 IWQDLFGIRIHWIVAALSVIILLAVGSDYNLLLVSRFREEIHGGLKTGII MSMEG_0576|M.smegmatis_MC2_155 LWQDLFGVEVHWLVMLMSVIILLAVGSDYNLLLVSRFKDEIHAGLKTGII .** :.. ::::: :::*:*****:*****:::*:::* .*: **:* Rv0450c|M.tuberculosis_H37Rv RSMGGTGKVVTNAGLVFAVTMASMAVSDLRVIGQVGTTIGLGLLFDTLIV MLBr_02378|M.leprae_Br4923 RSMGGTGKVVTNAGLVFAFTMASMVVSDLRVIGQVGTTIGLGLLFDTLIV TH_3260|M.thermoresistible__bu RAMGGSGSVVTAAGLVFGLTMMVMVVSDLTVMGQVGTTIGLGLLFDTFVV Mvan_3189|M.vanbaalenii_PYR-1 RAMGGSGSVVTAAGLVFALTMMSMAVSELTVIGQVGTTIGLGLLFDTLVI Mflv_4418|M.gilvum_PYR-GCK RAMAGTGSVVTSAGLVFAFTMASFAFSDLKVMAQVGTTIALGLLFDTLIV Mb1583|M.bovis_AF2122/97 RAMAGTGGVVTAAGLVFAATMSSFVFSDLRVLGQIGTTIGLGLLFDTLVV MAB_0987c|M.abscessus_ATCC_199 RAIAGTGGVVTAAGLVFAVTMSSFVFSDLRVLGQIGTTIGLGLLFDTLVV MMAR_3744|M.marinum_M RSMAGTGGVVTAAGLVFAFTMASMLGSDLRVLGQFGSTVCIGLLLDTLIV MUL_3688|M.ulcerans_Agy99 RSMAGTGGVVTAAGLVFAFTMASMLGSDLRVLGQFGSTVCIGLLLDTLIV MAV_1755|M.avium_104 RSMAGTGGVVTAAGLVFAFTMAAMLGSELRVLGQFGSTVCIGLLLDTLIV MSMEG_0576|M.smegmatis_MC2_155 RSMAGTGGVVTSAGLVFAATMAAMLGSELVVLAQMGSTIAIGLLLDTLIV *::.*:* *** *****. ** : *:* *:.*.*:*: :***:**::: Rv0450c|M.tuberculosis_H37Rv RSFMTPSIAALLGRWFWWPLRVRSRPAR---TPTVPSET--------QPA MLBr_02378|M.leprae_Br4923 RSFMMPSIAALLGRWFWWPQQGRTRPLL---TVAAPVGL--------PPD TH_3260|M.thermoresistible__bu RSFMMPSIATLLGRWFWWPQFVRKRPVP---QPWPSVPP--------RGP Mvan_3189|M.vanbaalenii_PYR-1 RAFMTPSIAALLGPWFWWPQRVRTRPVP---APWPRPGG--------LQS Mflv_4418|M.gilvum_PYR-GCK RSFMTPAVAALLGRWFWWPQKFRSAASE---RRLARIG---------VQP Mb1583|M.bovis_AF2122/97 RAFMTPSIAVLLGRWFWWPQRVRPRPASRMLRPYGPRPVVRELLLREGND MAB_0987c|M.abscessus_ATCC_199 RSFLTPAIATMLGRWFWWPINIRTRPAP---KPFGPKP--------TGAD MMAR_3744|M.marinum_M RTLLMPSIATLLGRWFWWPQVVHPRGDNARPRVAAPTH------------ MUL_3688|M.ulcerans_Agy99 RTLLMPSIATLLGRWFWWPQVVHPRGDNARPRVAAPTH------------ MAV_1755|M.avium_104 RTLLMPSIATLLGRWFWWPMVVHPRGDNARRPVPASS------------- MSMEG_0576|M.smegmatis_MC2_155 RSLLMPSIATLLGRWFWWPQVVYPRGDNHFRRPTAVSRG--------TGD *::: *::*.:** ***** Rv0450c|M.tuberculosis_H37Rv GRPLAMSSDRLG MLBr_02378|M.leprae_Br4923 -RSLVYSD---- TH_3260|M.thermoresistible__bu ATTDRVSV---- Mvan_3189|M.vanbaalenii_PYR-1 DPSEGVKV---- Mflv_4418|M.gilvum_PYR-GCK ATAGR------- Mb1583|M.bovis_AF2122/97 DPRTQVATHR-- MAB_0987c|M.abscessus_ATCC_199 DTTGPIPVSG-- MMAR_3744|M.marinum_M ------------ MUL_3688|M.ulcerans_Agy99 ------------ MAV_1755|M.avium_104 ------------ MSMEG_0576|M.smegmatis_MC2_155 EDTAALPVPS--