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SANHAHESRAAKIVRRLAVPIVLFWVAIAAVTNATVPQLEVVGEERSAPLNAADAPSTLAMRHIGKVFNE FDSDSSAMVVLEGEKPLGAQAHQFYNTLVQRLNDDHEHVQHVADYWGDPITAGGSQSKDGKAAYVQVYVA GNQGEALSNESVDAVRRIIAETPAPDGIKAYVSGEAPTITDQFEVGNAGAAQVTIITFAVIAVMLLVVYR SLITTALVLAMVMVELSAARGIVAALGHTGVIGLSTYATNLLTMLAIAAGTDYAIFFVGRYQEARSAGED RPSAYQTMYKSTAHVIIGSGLTVAGALFCLSFTRLPYFQTLGVPAALGVLVTLAAALTLAPAVLVIAGRF GLMEPKRAMRTRGWRRIGTAIVRWPGPILVVSCIATLVGLLALPGYRTTYDGRIYMPSSVPSNVGYAAAE RHFSVARLNPELLMIETDFDMRNPAGMVLLERVAKSVLHARGVALVQSITRPLGTPITHSSIPFQISASS ASQLMNLSQQQNQALYLSQQADQMTNTIAVLRQQLALQKQSAAITHEQTEGFQQTVAVAQDLRDKIANFD DQFRPIRNYFYWEPHCFDIPFCAALRSVFDALDGIDELVDALQSVTGSLTKLDALQPKLVDLIPPQIAIQ EKNRDLTLSNYAINNGTNTQNEESTRTATELGKAFDDAKNDDSFYLPPEAFDNPAFKRGMKLFMSPDGKA ARMIITHQGDPQTSEGIAHIDAIKEAAFDAVKATPLADAKIYVAGTASAYKDIADGQKYDLLMAALASLG LILLIMMFLTRSLVAALVIVGTVALSLAASFGMSVVVWQYIFGIPLYWVIFPLAVIILLAVGADYNLLLI SRFKEETGAGLKTGIIRAIAGTGGVVTAAGLVFAVTMSSFVFSDLRVLGQIGTTIGLGLLFDTLVVRSFL TPAIATMLGRWFWWPINIRTRPAPKPFGPKPTGADDTTGPIPVSG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. abscessus ATCC 19977 | MAB_0987c | - | - | 100% (956) | membrane protein MmpL |
M. abscessus ATCC 19977 | MAB_2301 | - | 0.0 | 55.17% (968) | putative membrane protein, mmpL |
M. abscessus ATCC 19977 | MAB_3150 | - | 0.0 | 55.85% (931) | MmpL family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1583 | mmpL6 | 0.0 | 67.72% (945) | transmembrane transport protein MmpL6 |
M. gilvum PYR-GCK | Mflv_4418 | - | 0.0 | 57.88% (926) | transport protein |
M. tuberculosis H37Rv | Rv0450c | mmpL4 | 0.0 | 58.15% (932) | transmembrane transport protein MmpL4 |
M. leprae Br4923 | MLBr_02378 | - | 0.0 | 56.30% (929) | hypothetical protein MLBr_02378 |
M. marinum M | MMAR_0775 | - | 0.0 | 59.53% (934) | MmpL family transport protein |
M. avium 104 | MAV_3863 | - | 0.0 | 67.09% (945) | MmpL4 protein |
M. smegmatis MC2 155 | MSMEG_3496 | - | 0.0 | 55.67% (943) | MmpL4 protein |
M. thermoresistible (build 8) | TH_3260 | - | 0.0 | 55.36% (943) | PUTATIVE MmpL4 protein |
M. ulcerans Agy99 | MUL_0757 | mmpL5 | 0.0 | 54.16% (949) | transmembrane transport protein, MmpL5 |
M. vanbaalenii PYR-1 | Mvan_1936 | - | 0.0 | 57.25% (931) | transport protein |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_4418|M.gilvum_PYR-GCK ---------------------------------MADAGRSGIGRIIRVLA Mvan_1936|M.vanbaalenii_PYR-1 ---------------------------------MADAGRSGIGRIIHLLA MSMEG_3496|M.smegmatis_MC2_155 ------------MSNP----SHDAPTDAMGVSGPKHARPGGIAKWIRVLA TH_3260|M.thermoresistible__bu -----------MTANPGHVRTDEAPTDRLDIKVSTHG-PSFISTWIRRLS MUL_0757|M.ulcerans_Agy99 -----------MTATT-----TDTPTDVVPP--AEHPPRPFIPRMIRTFA Rv0450c|M.tuberculosis_H37Rv ----------------------MSTKFANDSNTNARPEKPFIARMIHAFA MLBr_02378|M.leprae_Br4923 ----------------------MTVKCANDLDTHTKP--PFVARMIHRFA MMAR_0775|M.marinum_M MSDDQAVSERAASNGASNGAGAENGNGNENGNGNGNGSRPSMARLIHRMA Mb1583|M.bovis_AF2122/97 -------------------------------MSNHHRPRPWLPHTIRRLS MAV_3863|M.avium_104 -------------------------------MTTDQATRSVVAQTIRRLS MAB_0987c|M.abscessus_ATCC_199 -------------------------------MSANHAHESRAAKIVRRLA :: :: Mflv_4418|M.gilvum_PYR-GCK VPIVLGWVLLTVLTNVAVPSLEKVGEEHTVGMSAGDAPSMMSMKRVGANF Mvan_1936|M.vanbaalenii_PYR-1 VPIVLGWIALTVLTNVAVPSLEKVGEEHTVGMSANDAPSMMSMERVGANF MSMEG_3496|M.smegmatis_MC2_155 VPIILVWVAIIAVLNTVVPQLDVVGEMRSVSMSPDDAPSVIAMKRVGEVF TH_3260|M.thermoresistible__bu LPIIVGWIALIALLNITVPQLEVVGEMRAVSMSPDEAPSMVAMKRVGELF MUL_0757|M.ulcerans_Agy99 VPLILGWVLLIAVLNSVVPQLEVVGQMQAVSMSPDAAPSMISMKHIGKVF Rv0450c|M.tuberculosis_H37Rv VPIILGWLAVCVVVTVFVPSLEAVGQERSVSLSPKDAPSFEAMGRIGMVF MLBr_02378|M.leprae_Br4923 VPIILVWLAIAVTVSVFIPSLEDVGQERSVSLSPKDAPSYIAMQKMGQVF MMAR_0775|M.marinum_M VPIVVFWVGLVAVLVMFVPSLEEVGKQHTVSLSPSDAESMIAMKRVGKVF Mb1583|M.bovis_AF2122/97 LPILLFWVGVAAITNAAVPQLEVVGEAHNVAQSSPDDPSLQAMKRIGKVF MAV_3863|M.avium_104 VPILLVWVAVAAISNIAVPNLEDVAKAHNVSLNTPAAPSFQAMQHIGKVF MAB_0987c|M.abscessus_ATCC_199 VPIVLFWVAIAAVTNATVPQLEVVGEERSAPLNAADAPSTLAMRHIGKVF :*::: *: : . :*.*: *.: : . .. * :* ::* * Mflv_4418|M.gilvum_PYR-GCK EEFDSDSSAMVVLEGEQPLGDAAHRYYDQLIDELEADTANVQHIADFWGD Mvan_1936|M.vanbaalenii_PYR-1 DEFDSDSSAMVVLEGEQPLGDAAHRYYDELIGKLEADTANVQHVADFWGD MSMEG_3496|M.smegmatis_MC2_155 EEFKSNSSVMIVLEGEQPLGDEAHKYYDEIVDKLEADPAHVEHVQDFWGD TH_3260|M.thermoresistible__bu DEGSSDSQVMIVLEGEEPLGADARAFYDELVKRLEADDAHVENVQDLWSD MUL_0757|M.ulcerans_Agy99 REGDSDSAAMIVLEGQEPLGAAAHKFYDKMITKLRADTKHVQSVQDFWGD Rv0450c|M.tuberculosis_H37Rv KEGDSDSFAMVIIEGNQPLGDAAHKYYDGLVAQLRADKKHVQSVQDLWGD MLBr_02378|M.leprae_Br4923 NEGNSDSVIMIVLEGDKPLGDDAHRFYDGLIRKLRADK-HVQSVQDFWGD MMAR_0775|M.marinum_M NEFDTDSAVMIVLEGDHPLGDEAHHYYDELVRKLKADKDHVQHVQDFWGD Mb1583|M.bovis_AF2122/97 HEFDSDSAAMIVLEGDKPLGNDAHRFYDTLLRNLSNDTKHVEHVQDFWGD MAV_3863|M.avium_104 HEYDSDSAAMIVLEGDKPLGDDAHRFYDALVGKLEHDTKHVEHVQNFWGD MAB_0987c|M.abscessus_ATCC_199 NEFDSDSSAMVVLEGEKPLGAQAHQFYNTLVQRLNDDHEHVQHVADYWGD * .::* *:::**:.*** *: :*: :: .* * :*: : : *.* Mflv_4418|M.gilvum_PYR-GCK PLTASGAQSTDGKAAYVQVYLQGNQGEPRANEAVAAVREIVDRTP---AP Mvan_1936|M.vanbaalenii_PYR-1 PLTASGAQSTDGKAAYVQVYLQGNQGEPRANEAVAAVREIVDQTP---AP MSMEG_3496|M.smegmatis_MC2_155 PLTASGAQSPDGLASYVQVYTRGNQGEALANESVEAVQDIVESVP---AP TH_3260|M.thermoresistible__bu PLTATGVQSPDGKSAYVQVKLAGNQGEALANESVETVREMIATVSEEMAP MUL_0757|M.ulcerans_Agy99 PLTATGAQSGDGKAAYVQVKLAGNQGESLANESVEAVKTIVDSLQ---AP Rv0450c|M.tuberculosis_H37Rv PLTAAGVQSNDGKAAYVQLSLAGNQGTPLANESVEAVRSIVESTP---AP MLBr_02378|M.leprae_Br4923 PLTAPGAQSNDGKAAYVQLSLAGNQGELLAQESIDAVRKIVVQTP---AP MMAR_0775|M.marinum_M PLTAAGSQSPDGKAAYVQAYLVGNQGEAKANESVDAVRELVNDTP---AP Mb1583|M.bovis_AF2122/97 PLTAAGSQSTDGKAAYVQVYLAGNQGEALSIESVDAVRDIVAHTP---PP MAV_3863|M.avium_104 PLTAAGSQSKDGKAAYVQVYLAGNQGDALANESVDAIRNIVEHTP---PP MAB_0987c|M.abscessus_ATCC_199 PITAGGSQSKDGKAAYVQVYVAGNQGEALSNESVDAVRRIIAETP---AP *:** * ** ** ::*** **** : *:: ::: :: .* Mflv_4418|M.gilvum_PYR-GCK PGIKAYVTGGAPLVADQHSAGDTSVLRVTLITIGVIAVMLLIVFRSVATM Mvan_1936|M.vanbaalenii_PYR-1 PGLKAYVTGGAPLVADQHNAGDKSVFRVTLITIGVIAVMLLLVFRSVATM MSMEG_3496|M.smegmatis_MC2_155 PGVKAYVTGPAALSADQHVASDRSVRVIEALTFAVIITMLLLVYRSIVTV TH_3260|M.thermoresistible__bu EGVQAFVTGGAAMSADQQEAGDSSLRVIEALTFLVITTMLLFVYRSVITV MUL_0757|M.ulcerans_Agy99 PGVKVYVTGSAALVADQQLAGDRSLQLIEMVTFTVIIVMLLLVYRSIITA Rv0450c|M.tuberculosis_H37Rv PGIKAYVTGPSALAADMHHSGDRSMARITMVTVAVIFIMLLLVYRSIITV MLBr_02378|M.leprae_Br4923 PGITAWVTGASALIADMHHSGDKSMIRITATSVIVILVTLLLVYRSFITV MMAR_0775|M.marinum_M PGVKAYVTGPAALIADQSTAGDASIQRVTFITIGVIFVMLLSVYRSLITV Mb1583|M.bovis_AF2122/97 AGVKAYVTGAAPLMADQFQVGSKGTAKVTGITLVVIAVMLLFVYRSVVTM MAV_3863|M.avium_104 PGVKAYVTGAAPLVTDQFEVGSKGIFKVTVITVLVILAMLLWVYRS-VTA MAB_0987c|M.abscessus_ATCC_199 DGIKAYVSGEAPTITDQFEVGNAGAAQVTIITFAVIAVMLLVVYRSLITT *: .:*:* :. :* .. . : :. ** ** *:** * Mflv_4418|M.gilvum_PYR-GCK VLILFMVFAELGAARGIVAFLADAEIIGLSTFATSLLTLMVIAAGTDYAI Mvan_1936|M.vanbaalenii_PYR-1 VLILFMVFAELGAARGIVAFLANAEIIGLSTFATSLLTLMVIAAGTDYAI MSMEG_3496|M.smegmatis_MC2_155 ILTLVMVVLSLSAARGMIAFLGYHEIIGLSVFATNLLTTLAIAAATDYAI TH_3260|M.thermoresistible__bu LIALFMVLIGLLTTRGVVAFLGYHNIIGLSTFATSLLVTLAIAIAVDYAI MUL_0757|M.ulcerans_Agy99 AIMLTMVVLGLLATRGGVAFLGYHRIIGLSTFATNLLVVLAIAAATDYAI Rv0450c|M.tuberculosis_H37Rv VLLLITVGVELTAARGVVAVLGHSGAIGLTTFAVSLLTSLAIAAGTDYGI MLBr_02378|M.leprae_Br4923 ILLLFTVGIESAVARGVVALLGHTGLIGLSTFAVNLLTSLAIAAGTDYGI MMAR_0775|M.marinum_M ISVLVMVGIELMAARGVVAFLADNNVIGLSTFAVNLLVLMAIAAGTDYAI Mb1583|M.bovis_AF2122/97 VLVLITVLIELAAARGIVAFLGNAGVIGLSTYSTNLLTLLVIAAGTDYAI MAV_3863|M.avium_104 VFVLVTVIVEMAAARGIVAFLGSVGLIGLSTYATNLLTLLVIAAGTDYAI MAB_0987c|M.abscessus_ATCC_199 ALVLAMVMVELSAARGIVAALGHTGVIGLSTYATNLLTMLAIAAGTDYAI * * .:** :* *. ***:.::..**. :.** ..**.* Mflv_4418|M.gilvum_PYR-GCK FAIGRYQEARGAGEDRETAYYTMFRGTAHVVLGSGLTIAGAMLCLSFTRL Mvan_1936|M.vanbaalenii_PYR-1 FAIGRYQEARGAGEDRETAYYTMFRGTAHVVLGSGLTIAGAMLCLSFTRL MSMEG_3496|M.smegmatis_MC2_155 FLIGRYQEARSVGEDREQSYYTMFHSTAHVVLGSGMTIAGATLCLHFTRM TH_3260|M.thermoresistible__bu FLIGRYQEARSVGADRATAYHTMFGGTAHVILASGLTIAGATFCLSFTRL MUL_0757|M.ulcerans_Agy99 FLIGRYQEARGLGQDRESAYYTMFGGTAHVVLGSGLTIAGATFCLSFTRL Rv0450c|M.tuberculosis_H37Rv FIIGRYQEARQAGEDKEAAYYTMYRGTAHVILGSGLTIAGATFCLSFARM MLBr_02378|M.leprae_Br4923 FITGRYQEARQANENKEAAFYTMYRGTFHVILGSGLTISGATFCLSFARM MMAR_0775|M.marinum_M FVLGRYQEARGEGESREKAFYTMFHGTAHVVLGSGLTIAGAMYCLSFTRL Mb1583|M.bovis_AF2122/97 FVLGRYHEARYAAQDRETAFYTMYRGTAHVVLGSGLTVAGAVYCLSFTRL MAV_3863|M.avium_104 FFVGRYHEARHEGQDRETAYYTMYRGTTHVVLGSGLTVAGAVLCLRFTRL MAB_0987c|M.abscessus_ATCC_199 FFVGRYQEARSAGEDRPSAYQTMYKSTAHVIIGSGLTVAGALFCLSFTRL * ***:*** .: :: **: .* **::.**:*::** ** *:*: Mflv_4418|M.gilvum_PYR-GCK PYFQTMGVPCAVGTFVAVIAALTLGPAVIVIGSRFG-LFDPKRAISSRGW Mvan_1936|M.vanbaalenii_PYR-1 PYFQTMGVPCAVGTFVAVMAALTLGPAVVAIGSRFG-LFDPKRAISSRGW MSMEG_3496|M.smegmatis_MC2_155 PYFQSLGIPLAIGMSVVVLASLTMGAAIISVASRFGKTFEPKRAMRTRGW TH_3260|M.thermoresistible__bu PYFQSLGPPLAIGMIVLIVTSLTMGPAIITVATRFG-LLEPKRAARVRFW MUL_0757|M.ulcerans_Agy99 PYFQTLGVPLAIGMVIVVATALTLGPALIAVMSRFGKLLEPKRMARVRGW Rv0450c|M.tuberculosis_H37Rv PYFQTLGIPCAVGMLVAVAVALTLGPAVLHVGSRFG-LFDPKRLLKVRGW MLBr_02378|M.leprae_Br4923 PYFQTLGVPCAVGMLIAVAVALTLGPAVLTVGSRFG-LFEPKRLIKVRGW MMAR_0775|M.marinum_M PYFQTLGAPCAVGMLVAVLAALTLGPAVLVVGSFFK-LFDPKRKMRTRGW Mb1583|M.bovis_AF2122/97 PYFQSLGIPASIGVMIALAAALSLAPSVLILGSRFG-CFEPKRRMRTRGW MAV_3863|M.avium_104 NYFQSLGIPAAIGIGVALAAALSLTPAVITVGSLFG-LFDPKRQMATRGW MAB_0987c|M.abscessus_ATCC_199 PYFQTLGVPAALGVLVTLAAALTLAPAVLVIAGRFG-LMEPKRAMRTRGW ***::* * ::* : : .:*:: .::: : * ::*** * * Mflv_4418|M.gilvum_PYR-GCK RRIGVSVVRWPGPVLAATLALALVGLVTLPGYKTNYDARDYLPEDIPANV Mvan_1936|M.vanbaalenii_PYR-1 RRIGVSVVRWPGPVLAATLALALVGLVALPGYKTNYDSRDYLPEDVPANV MSMEG_3496|M.smegmatis_MC2_155 RKLGAAVVRWPAPILVTTIALSVVGLLALPGYQTNYNDRRYLPQDLPANT TH_3260|M.thermoresistible__bu RKVGASVVRWPGPIMVTTVAVTLVGLLALPGYRTNYNDRNYLPASFPSNA MUL_0757|M.ulcerans_Agy99 RKIGAAIVRWPGPILIGAVALALVGLLTLPGYKTNYNDRNYLPADLPANE Rv0450c|M.tuberculosis_H37Rv RRVGTVVVRWPLPVLVATCAIALVGLLALPGYKTSYNDRDYLPDFIPANQ MLBr_02378|M.leprae_Br4923 RRIGTVVVRWPLPILITTCAIAMVGLLALPGYRTNYKDRAYLPASIPANQ MMAR_0775|M.marinum_M RRVGTAIVRWPGPILAVSIAIALIGLLALPGYRTNYDSKKYLPASTPTNV Mb1583|M.bovis_AF2122/97 RRIGTAIVRWPGPILAVACAIAVVGLLALPGYKTSYDARYYMPATAPANI MAV_3863|M.avium_104 RRIGTAIVRWPGPILVVATGVALVGLLALPGYRTNYDARPYMPASAPANT MAB_0987c|M.abscessus_ATCC_199 RRIGTAIVRWPGPILVVSCIATLVGLLALPGYRTTYDGRIYMPSSVPSNV *::*. :**** *:: : :::**::****:*.*. : *:* *:* Mflv_4418|M.gilvum_PYR-GCK GYAVADQHFGSARMNPELLMVESDHDLRNPADFLVIDKIAKSVFRVPGVA Mvan_1936|M.vanbaalenii_PYR-1 GYAVADRHFGSARMNPELLMVESDHDLRNPADFLVIDKIAKAIFRVPGVA MSMEG_3496|M.smegmatis_MC2_155 GYAAADRHFSQARMNPELLMIESDHDLRNSADFLVVDRIAKRVFQVPGIS TH_3260|M.thermoresistible__bu GYEAAERHFDPARLNPELLLIESDHDLRNPADFLVIEKIAKAVFQVEGIS MUL_0757|M.ulcerans_Agy99 GYSAAERHFSQARMNPEVLMVESDHDMRNSSDFLVINKIAKAIFGVEGIS Rv0450c|M.tuberculosis_H37Rv GYAAADRHFSQARMKPEILMIESDHDMRNPADFLVLDKLAKGIFRVPGIS MLBr_02378|M.leprae_Br4923 GFAAADRHFPQARMKPEILMIESDHDMRNPADFLILDKLARGIFRVPGIS MMAR_0775|M.marinum_M GYTAADRHFSQARMNPELLMVETDHDMRNPADMLVIDRIAKGVFHLPGVA Mb1583|M.bovis_AF2122/97 GYMAAERHFPQARLNPELLMIETDHDMRNPADMLILDRIAKAVFHLPGIG MAV_3863|M.avium_104 GYTAAERHFSQARLNPELLMIETDHDMRNPADMINLERVAKAIAHLPGIA MAB_0987c|M.abscessus_ATCC_199 GYAAAERHFSVARLNPELLMIETDFDMRNPAGMVLLERVAKSVLHARGVA *: .*::** **::**:*::*:*.*:**.:.:: ::::*: : *:. Mflv_4418|M.gilvum_PYR-GCK RVQTITRPDGKPIKHTTIPFQMSMQGTTQRLNEKYLQDRMADMLVQADAM Mvan_1936|M.vanbaalenii_PYR-1 RVQTITRPDGKPIKHTTIPFQMSMRSTTSRLNEKYMQDRMADMLVQADAM MSMEG_3496|M.smegmatis_MC2_155 RVQAITRPQGTPIEHTSIPFQISMSGTTQMMNMKYMQDRMADMLVMADEM TH_3260|M.thermoresistible__bu RVQGITRPEGTPIEHSSIPFMISQQGTLQILNQQYMQDRMADMLVQADEM MUL_0757|M.ulcerans_Agy99 RVQAITRPDGKPIEHTSIPFLISMQGTSQKLTEKYNQDLTTSMLQQVNDI Rv0450c|M.tuberculosis_H37Rv RVQAITRPEGTTMDHTSIPFQISMQNAGQLQTIKYQRDRANDMLKQADEM MLBr_02378|M.leprae_Br4923 RVQAITRPDGTAMDHTSIPFQISMQNAGQVQTMKYQKDRMNDLLRQAENM MMAR_0775|M.marinum_M RVQAVTRPLGKPIEHSSIPFQISMQNTVQVENMQYMKQRMADMLIQAAAM Mb1583|M.bovis_AF2122/97 LVQAMTRPLGTPIDHSSIPFQISMQSVGQIQNLKYQRDRAADLLKQAEEL MAV_3863|M.avium_104 QVQSMTRPLGTPIEHTSLAFQISAGSIGSIENLQYQKERAEDLLKQADNL MAB_0987c|M.abscessus_ATCC_199 LVQSITRPLGTPITHSSIPFQISASSASQLMNLSQQQNQALYLSQQADQM ** :*** *..: *:::.* :* . . . . :: : . : Mflv_4418|M.gilvum_PYR-GCK QTNVDTMTRMQSLMGQMSATTHEMVLKTKKTEIDIIEVRDNLADFDDFFR Mvan_1936|M.vanbaalenii_PYR-1 QTNVDTMTKMQSLMTQMSAATHDMVTKTKKTAVDIVEVRDYLANLDDFVR MSMEG_3496|M.smegmatis_MC2_155 QKSVDTMEEMLKITREMSDTTHSMVGKMHGMVEDIKELRDHIADFDDFLR TH_3260|M.thermoresistible__bu QLMIDTMDKMIALMEEMVETTDNMVRDMDEMAAHVAEMRDSISEFDDFFR MUL_0757|M.ulcerans_Agy99 QTNIDQMERMHDLTQQMADVTHQMVIQMKGMVVDVEELRNHIADFDDFFR Rv0450c|M.tuberculosis_H37Rv ATTIAVLTRMHSLMAEMASTTHRMVGDTEEMKEITEELRDHVADFDDFWR MLBr_02378|M.leprae_Br4923 AETIASMRRMHQLMALLTENTHHILNDTVEMQKTTSKLRDEIANFDDFWR MMAR_0775|M.marinum_M QDSIDTLDRMYDIMGKMVETTHDMDGLTHDMVEITDELRDHIADFDDFWR Mb1583|M.bovis_AF2122/97 GKTIEILQRQYALQQELAAATHEQAESFHQTIATVKELRDRIANFDDFFR MAV_3863|M.avium_104 KDTIGILNQQYALQKQLAASTHDETQSFHDTIAIINDLRDKIANFDDFFR MAB_0987c|M.abscessus_ATCC_199 TNTIAVLRQQLALQKQSAAITHEQTEGFQQTVAVAQDLRDKIANFDDQFR : : . : *. .:*: ::::** * Mflv_4418|M.gilvum_PYR-GCK PVRNYFYWEPHCYDIPVCWTMRSVFDTLDGINPLTDDISELIPDLERLDE Mvan_1936|M.vanbaalenii_PYR-1 PVRNYFYWEPHCYNIPVCATMRSVFDTLDGINPLTDDIQELIPDLERLDA MSMEG_3496|M.smegmatis_MC2_155 PIRNYFYWEPHCDSIPVCQSIRSIFDTLDGIDVMTDDIQRLMPDMDRLDE TH_3260|M.thermoresistible__bu PIRNYFYWEPHCYNIPVCWAMRSVFDTLDGINTMTDDIQNMLPHMHRLND MUL_0757|M.ulcerans_Agy99 PIRSYFYWEKHCFDIPVCWSLRSVFDTLDGVDLMTEDINNLLPLMERLDT Rv0450c|M.tuberculosis_H37Rv PIRSYFYWEKHCYGIPICWSFRSIFDALDGIDKLSEQIGVLLGDLREMDR MLBr_02378|M.leprae_Br4923 PIRSYFYWERHCFNIPICWSFRSIFDALDGVDQIDERLNSIVGDIKNMDL MMAR_0775|M.marinum_M PIRSYFYWEKHCYDVPICWSLRSIFDALDGVDKITEKLAALSRDMDRLDI Mb1583|M.bovis_AF2122/97 PIRSYFYWEKHCYDIPSCWALRSVFDTIDGIDQLGEQLASVTVTLDKLAA MAV_3863|M.avium_104 PVRSYFYWEKHCFDIPACFAFRSVFDALDGIDELSAQFEKLTASLDKLDA MAB_0987c|M.abscessus_ATCC_199 PIRNYFYWEPHCFDIPFCAALRSVFDALDGIDELVDALQSVTGSLTKLDA *:*.***** ** .:* * ::**:**::**:: : : : : .: Mflv_4418|M.gilvum_PYR-GCK LMPQLIALLPSQIETMRSMQAMMLRQYQTQKGQLDQNAAMSEDADAMGEA Mvan_1936|M.vanbaalenii_PYR-1 LMPQLIALLPSQIESMRNMQSMMLTMYQSQKGLQDQMASQSEDADAMGEA MSMEG_3496|M.smegmatis_MC2_155 LMPQMLTIMPPMIESMKTMKTMMLTTQATMGGLQDQMEAAMENQTAMGQA TH_3260|M.thermoresistible__bu LMPQMLTLLPTTVATMKTMRSMLLTMQATNAGLQDQMAEMQENANAMGEA MUL_0757|M.ulcerans_Agy99 LMPQMTAMMPEMIQTMKSMKAQMLSMHSTQQGLQDQMAAMQEDSSAMGEA Rv0450c|M.tuberculosis_H37Rv LMPQMVAQIPPQIEAMENMRTMILTMHSTMTGIFDQMLEMSDNATAMGKA MLBr_02378|M.leprae_Br4923 LMPQMLEQFPPMIESMESMRTIMLTMHSTMSGIFDQMNELSDNANTMGKA MMAR_0775|M.marinum_M LMPQMRAQIPFQIASMKTMKTMMLTMHSSMSSLYDQMDEMSKNSTAMGKA Mb1583|M.bovis_AF2122/97 IQPQLVALLPDEIASQQINRELALANYATMSGIYAQTAALIENAAAMGQA MAV_3863|M.avium_104 GQQKLVTLLPPQIADQEKNLALTLSNYATNLGINAQTRANTDTATALGQA MAB_0987c|M.abscessus_ATCC_199 LQPKLVDLIPPQIAIQEKNRDLTLSNYAINNGTNTQNEESTRTATELGKA :: :* : . * . * :*:* Mflv_4418|M.gilvum_PYR-GCK FDDSMNDDSFYLPPEAFDNDDFKRGMENFISPDGRSVRFIISHEGDPATV Mvan_1936|M.vanbaalenii_PYR-1 FDDSMNDDSFYLPPEAFDNDDFKRGIENFISPDGKSVRFIIAHEGDPATV MSMEG_3496|M.smegmatis_MC2_155 FDASKNDDSFYLPPETFENPDFKRGMKMFLSPDGHAVRFIISHEGDPMSP TH_3260|M.thermoresistible__bu FDQARNDDSFYLPPEAFDNPDFQRGLEQFLSPDGHAVRFIISHQGDPMTP MUL_0757|M.ulcerans_Agy99 FDSSRNDDSFYLPPEVFNNPDFKRGLEQFLSPDGHAVRFIISHEGDPMSQ Rv0450c|M.tuberculosis_H37Rv FDAAKNDDSFYLPPEVFKNKDFQRAMKSFLSSDGHAARFIILHRGDPQSP MLBr_02378|M.leprae_Br4923 FDTAKNDDSFYLPPEVFKNTDFKRAMKSFLSSDGHAARFIILHRGDPASV MMAR_0775|M.marinum_M FDAARNDDSFYIPPEVFDNADFKRGLKMFLSPDGHAVRFIISHEGDPAST Mb1583|M.bovis_AF2122/97 FDAAKNDDSFYLPPEAFDNPDFQRGLKLFLSADGKAARMIISHEGDPATP MAV_3863|M.avium_104 YDAAKNDDSFYLPPEAFTNPEFKRGLKLFLSPDGKAARMIISHEGDPATP MAB_0987c|M.abscessus_ATCC_199 FDDAKNDDSFYLPPEAFDNPAFKRGMKLFMSPDGKAARMIITHQGDPQTS :* : ******:***.* * *:*.:: *:*.**::.*:** *.*** : Mflv_4418|M.gilvum_PYR-GCK EGISEVVPIKTAAKEAIKGTPLEGSTVYLAGTAATYKDMSDGAFYDLLIA Mvan_1936|M.vanbaalenii_PYR-1 EGISRVLPIKTAAKEAIKGTPLEGSTVYLAGTAATYKDMRDGANYDLLIA MSMEG_3496|M.smegmatis_MC2_155 EGIKHIDAIKQAAKEAIKGTPLEGSKIYLGGTAATFKDLQEGANYDLIIA TH_3260|M.thermoresistible__bu EGLAKIEPIKKAAVEAIKGTPLEGSRVYLGGTAAVFKDMSDGTKYDLIIA MUL_0757|M.ulcerans_Agy99 AGINHIDKIKTAAKEAIKGTPLEGSTIYLGGTVAMFKDLSDGNTFDLMIA Rv0450c|M.tuberculosis_H37Rv EGIKSIDAIRTAAEESLKGTPLEDAKIYLAGTAAVFHDISEGAQWDLLIA MLBr_02378|M.leprae_Br4923 AGIASINAIRTAAEEALKGTPLEDTKIYLAGTAAVFKDIDEGANWDLVIA MMAR_0775|M.marinum_M EGISHVKPIMDEAKQAIKGTPLEGAKIYLAGTASVYKDMRDGSRWDLLIA Mb1583|M.bovis_AF2122/97 EGISHIDAIKQAAHEAVKGTPMAGAGIYLAGTAATFKDIQDGATYDLLIA MAV_3863|M.avium_104 EGISHIEPIRNAAKQAVKNTPLGDSNIYLAGTAATYKDIAEGAKYDLLIA MAB_0987c|M.abscessus_ATCC_199 EGIAHIDAIKEAAFDAVKATPLADAKIYVAGTASAYKDIADGQKYDLLMA *: : * * :::* **: .: :*:.**.: ::*: :* :**::* Mflv_4418|M.gilvum_PYR-GCK GIAAVTLIFVIMLVITRSVVAAAVIVGTVLLSLGASFGLSVLLWQHIIGL Mvan_1936|M.vanbaalenii_PYR-1 GIAAVTLIFVIMLIITRSVVAAAVIVGTVLLSLGASFGLSVLLWQHIIGL MSMEG_3496|M.smegmatis_MC2_155 GIAALCLIFIIMLIITRAVVASAVIVGTVVISLGASFGLSVLIWQHIIGL TH_3260|M.thermoresistible__bu AIAAVCLIFIIMLILTRAVVAAAVIVGTVTLSLAASFGVSVLIWQYIVGL MUL_0757|M.ulcerans_Agy99 GISALCLIFIIMLIITRSVVAAAVIVGTVVLSLGASFGLSVLIWQHVLGI Rv0450c|M.tuberculosis_H37Rv AISSLCLIFIIMLIITRAFIAAAVIVGTVALSLGASFGLSVLLWQHILAI MLBr_02378|M.leprae_Br4923 GISSLCLIFIIMLIITRAFVAAAVIVGTVALSLGASFGLSVLLWQHILGI MMAR_0775|M.marinum_M GVAAVSLILIIMLIITRSLVAAVVIVGTVLLSLGASFGLSVLVWQDIFGV Mb1583|M.bovis_AF2122/97 GIAALSLILLIMMIITRSLVAALVIVGTVALSLGASFGLSVLVWQHLLGI MAV_3863|M.avium_104 GIAALSLILLIMVLITRSLVAAIVIVGTVALSLGASFGLSVLVWQDILGI MAB_0987c|M.abscessus_ATCC_199 ALASLGLILLIMMFLTRSLVAALVIVGTVALSLAASFGMSVVVWQYIFGI .:::: **::**:.:**:.:*: ****** :**.****:**::** :..: Mflv_4418|M.gilvum_PYR-GCK ALHWMVLPMAVILLLAVGSDYNLLLVSRFKEELSGGLKTGIIRAMAGTGS Mvan_1936|M.vanbaalenii_PYR-1 ALHWMVLPMAVILLLAVGSDYNLLLVSRFKEELAGGLKTGIIRSMAGTGS MSMEG_3496|M.smegmatis_MC2_155 ELHWMVLAMAVIVLLAVGADYNLLLVSRIKEEIHAGLNTGIIRSMGGTGS TH_3260|M.thermoresistible__bu EMHWMVFPMALIILLAVGADYNLLVVARLREEIPAGLNTGMIRAMGGSGS MUL_0757|M.ulcerans_Agy99 ELHWLVLAMAVIILLAVGADYNLLLVARLKEEIHAGINTGIIRAMGGSGS Rv0450c|M.tuberculosis_H37Rv HLHWLVLAMSVIVLLAVGSDYNLLLVSRFKQEIGAGLKTGIIRSMGGTGK MLBr_02378|M.leprae_Br4923 ELHYLVLAMSVIVLLAVGSDYNLLLVSRFKQEIQAGLKTGIIRSMGGTGK MMAR_0775|M.marinum_M ELHWMVLAMSVILLLAVGSDYNLLLVSRLKEEIGAGLKTGIIRAMAGTGG Mb1583|M.bovis_AF2122/97 QLYWIVLALAVILLLAVGSDYNLLLISRFKEEIGAGLNTGIIRAMAGTGG MAV_3863|M.avium_104 KLYWICLALSVIILLAVGSDYNLLLISRFREEIHAGLNTGIIRSMAGSGA MAB_0987c|M.abscessus_ATCC_199 PLYWVIFPLAVIILLAVGADYNLLLISRFKEETGAGLKTGIIRAIAGTGG :::: :.:::*:*****:*****:::*:::* .*::**:**::.*:* Mflv_4418|M.gilvum_PYR-GCK VVTSAGLVFAFTMASFAFSDLKVMAQVGTTIALGLLFDTLIVRSFMTPAV Mvan_1936|M.vanbaalenii_PYR-1 VVTSAGLVFAFTMASFAFSDLKVMAQVGTTIALGLLFDTLIVRSFMTPAV MSMEG_3496|M.smegmatis_MC2_155 VVTSAGLVFAFTMMSMAVSELAVIAQVGTTIGLGLLFDTLVIRSFMTPSI TH_3260|M.thermoresistible__bu VVTAAGLVFGLTMMVMVVSDLTVMGQVGTTIGLGLLFDTFVVRSFMMPSI MUL_0757|M.ulcerans_Agy99 VVTAAGLVFAFTMMSFAVSELTVMAQVGTTIGMGLLFDTLIVRSFMTPSI Rv0450c|M.tuberculosis_H37Rv VVTNAGLVFAVTMASMAVSDLRVIGQVGTTIGLGLLFDTLIVRSFMTPSI MLBr_02378|M.leprae_Br4923 VVTNAGLVFAFTMASMVVSDLRVIGQVGTTIGLGLLFDTLIVRSFMMPSI MMAR_0775|M.marinum_M VVTTAGLVFAATMASFIFSDLRVIGQVGTTIGLGLLFDTLIVRSFMTPSI Mb1583|M.bovis_AF2122/97 VVTAAGLVFAATMSSFVFSDLRVLGQIGTTIGLGLLFDTLVVRAFMTPSI MAV_3863|M.avium_104 VVTSAGLVFAFTMASFVSASLLVLGQIGTTIALGLLFDTLIVRSFMTPSV MAB_0987c|M.abscessus_ATCC_199 VVTAAGLVFAVTMSSFVFSDLRVLGQIGTTIGLGLLFDTLVVRSFLTPAI *** *****. ** : :.* *:.*:****.:******:::*:*: *:: Mflv_4418|M.gilvum_PYR-GCK AALLGRWFWWPQKFRSAASERRLARIGVQPATAGR--------------- Mvan_1936|M.vanbaalenii_PYR-1 AALLGRWFWWPQKVRSHASQRRLAALNH---------------------- MSMEG_3496|M.smegmatis_MC2_155 AALMGKWFWWPQRVRQRPLPAPWPQPVQRDPEDALNRV------------ TH_3260|M.thermoresistible__bu ATLLGRWFWWPQFVRKRPVPQPWPSVPPRGP-ATTDRVSV---------- MUL_0757|M.ulcerans_Agy99 AALLGKWFWWPQVVRQRPAPQPWPTPAPTPPPATTSV------------- Rv0450c|M.tuberculosis_H37Rv AALLGRWFWWPLRVRSRPARTPTVPSETQPAGRPLAMSSDRLG------- MLBr_02378|M.leprae_Br4923 AALLGRWFWWPQQGRTRPLLTVAAPVGLPPD-RSLVYSD----------- MMAR_0775|M.marinum_M AALMGRWFWWPQQVRTRPASQLLRPYGPRPLVRALLLPRNGDSADGPEDT Mb1583|M.bovis_AF2122/97 AVLLGRWFWWPQRVRPRPASRMLRPYGPRPVVRELLLREGND---DPRTQ MAV_3863|M.avium_104 AALLGRWFWWPQRVRPRPASTMLRPYGPRPAVRQLLLWEDGDPAVAPETP MAB_0987c|M.abscessus_ATCC_199 ATMLGRWFWWPINIRTRPAP---KPFGPKPTG--------ADDTTGPIPV *.::*:***** * . Mflv_4418|M.gilvum_PYR-GCK ------------ Mvan_1936|M.vanbaalenii_PYR-1 ------------ MSMEG_3496|M.smegmatis_MC2_155 ------------ TH_3260|M.thermoresistible__bu ------------ MUL_0757|M.ulcerans_Agy99 ------------ Rv0450c|M.tuberculosis_H37Rv ------------ MLBr_02378|M.leprae_Br4923 ------------ MMAR_0775|M.marinum_M NTERLAVSSPHY Mb1583|M.bovis_AF2122/97 VATHR------- MAV_3863|M.avium_104 SAARHSRG---- MAB_0987c|M.abscessus_ATCC_199 SG----------