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SDASNKTQPDLSAADTGPINVKGLSKAERGHRPYLPHAIRIFAVPIILGWLFVTVLVNVIVPTLEKVGEA HSAPMTPLDAPSMKAMMRLGHNFHEFDSNSTVMIVLEGQQPLGPDAHKYYDNLIRQLRQDPKHIQHIQDF WGDRLTAAGAQSADAKGAYVQVNLAGNQGTTLANESVDAVRKVIDENKAPPGVKAYVTGPAALSDDMHII GNASLAKITLFTLGAIAIMLLLVYRSIVTTLVQLFMTFVALACSRGVVAVLAYHNAFGLTTFAANILTML AIAAGTDYGIFLIGRYQEALAAGEDRESAYYTTFKGVAPVVLGSGLTIAGATYCLSFSRLPWFNTMGAPV AIGMLVVVLAGVTLGPAVVFVGSRFHFFERQAKRGRLWRRVGTAVVRWPAPVLAVSAAVVLVGMIALPSF HTSYNDRHYLPLSAPSNQGQEAANRHFSEARMNPDLLMIESDHDMRNPADMLVLDRVAKNEMRTLGIAMV QDITRPLGIPIQHSSIPFQNSVQSQTTMQNMGFLKERMNDILKMADDLQTQIDTTQRQYEVSMDLANAAD DSAKTTAVTSQITDSLRDHIADFDDTFRPIRTYFYWEKHCYDIPVCIGLRSLFDTFDGFDQLAEQFHYLT TDIAHTAKASRDLTALFPTLITTLKTTRGITLTLYQTFKAMIDQMEAMSNTAVVMGQSFDASKNDDFFYL PPEAFDNPDFQTGLRMFLSPDGKSARFFITHQGDPMSPEGIKRVDAERTAAQEGLKQSSLSDARVYLGGT AATFKDMADGEKYDLMIAVVSALTLIFMIMLLLTRSVVAALVIVGTAASSIAASFGLSVLIWQDLFGIRI HWIVAALSVIILLAVGSDYNLLLVSRFREEIHGGLKTGIIRSMAGTGGVVTAAGLVFAFTMAAMLGSELR VLGQFGSTVCIGLLLDTLIVRTLLMPSIATLLGRWFWWPMVVHPRGDNARRPVPASS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1755 | - | - | 100% (968) | MmpL4 protein |
| M. avium 104 | MAV_0084 | - | 0.0 | 56.73% (943) | putative transport protein MmpL4 |
| M. avium 104 | MAV_2510 | - | 0.0 | 55.86% (938) | MmpL4 protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0458c | mmpL4 | 0.0 | 57.93% (939) | transmembrane transport protein MmpL4 |
| M. gilvum PYR-GCK | Mflv_4418 | - | 0.0 | 57.02% (912) | transport protein |
| M. tuberculosis H37Rv | Rv0450c | mmpL4 | 0.0 | 58.04% (939) | transmembrane transport protein MmpL4 |
| M. leprae Br4923 | MLBr_02378 | - | 0.0 | 54.90% (918) | hypothetical protein MLBr_02378 |
| M. abscessus ATCC 19977 | MAB_4382c | - | 0.0 | 54.56% (931) | putative membrane protein, MmpL |
| M. marinum M | MMAR_3744 | mmpL4_1 | 0.0 | 81.79% (961) | transmembrane transport protein MmpL4_1 |
| M. smegmatis MC2 155 | MSMEG_0576 | - | 0.0 | 68.73% (937) | MmpL4 protein |
| M. thermoresistible (build 8) | TH_3260 | - | 0.0 | 53.55% (930) | PUTATIVE MmpL4 protein |
| M. ulcerans Agy99 | MUL_3688 | mmpL4_1 | 0.0 | 81.37% (961) | transmembrane transport protein MmpL4_1 |
| M. vanbaalenii PYR-1 | Mvan_3189 | - | 0.0 | 56.52% (943) | transport protein |
CLUSTAL 2.0.9 multiple sequence alignment
TH_3260|M.thermoresistible__bu ---------MTANPGHVRTDEAPTDRLDI-KVSTHGPSFISTWIRRLSLP
Mvan_3189|M.vanbaalenii_PYR-1 ---------MSAPVSDARTDEFPAAR------QPHRP-FIPRMIRLFAVP
MAB_4382c|M.abscessus_ATCC_199 ---------MSKPMNDPTTDAFPAAR------HAARP-WLPRMIRVLAVP
Mflv_4418|M.gilvum_PYR-GCK -------------MADAGRSG------------------IGRIIRVLAVP
Mb0458c|M.bovis_AF2122/97 ---------MSTKFANDSNTNARPEK-----------PFIARMIHAFAVP
Rv0450c|M.tuberculosis_H37Rv ---------MSTKFANDSNTNARPEK-----------PFIARMIHAFAVP
MLBr_02378|M.leprae_Br4923 ---------MTVKCANDLDTHTKP-------------PFVARMIHRFAVP
MMAR_3744|M.marinum_M MSESN--SGASISTEDTGPIEIGAATGGAPNRERGHRPVIPHTIRILAVP
MUL_3688|M.ulcerans_Agy99 MSESN--SGASISTEDTGPIEIGAATGGAPNRERGHRPVIPHTIRILAVP
MAV_1755|M.avium_104 MSDASNKTQPDLSAADTGPINVKGLS----KAERGHRPYLPHAIRIFAVP
MSMEG_0576|M.smegmatis_MC2_155 --------------------MIQGLH-----NRSDSRPLLPHALRVLAIP
: :: :::*
TH_3260|M.thermoresistible__bu IIVGWIALIALLNITVPQLEVVGEMRAVSMSPDEAPSMVAMKRVGELFDE
Mvan_3189|M.vanbaalenii_PYR-1 IILGWIALIVILNVTVPQLEAVGEARAVSMSPNEAPSLISMKKVGELFRE
MAB_4382c|M.abscessus_ATCC_199 IVLGWIAVTIALNTVVPQLEEVGHMRAVSMSPNDAPAMIATKRVGEVFEE
Mflv_4418|M.gilvum_PYR-GCK IVLGWVLLTVLTNVAVPSLEKVGEEHTVGMSAGDAPSMMSMKRVGANFEE
Mb0458c|M.bovis_AF2122/97 IILGWLAVCVVVTVFVPSLEAVGQERSVSLSPKDAPSFEAMGRIGMVFKE
Rv0450c|M.tuberculosis_H37Rv IILGWLAVCVVVTVFVPSLEAVGQERSVSLSPKDAPSFEAMGRIGMVFKE
MLBr_02378|M.leprae_Br4923 IILVWLAIAVTVSVFIPSLEDVGQERSVSLSPKDAPSYIAMQKMGQVFNE
MMAR_3744|M.marinum_M IILGWVLLTVLVNVVVPSLEVVSEQHSAPMTPMDAPSMKAMMRLGHNFRE
MUL_3688|M.ulcerans_Agy99 IILGWVLLTVLVNVVVPSLEVVSEQHSAPMTPMDAPSMKAMMRLGHNFRE
MAV_1755|M.avium_104 IILGWLFVTVLVNVIVPTLEKVGEAHSAPMTPLDAPSMKAMMRLGHNFHE
MSMEG_0576|M.smegmatis_MC2_155 VILFWVAFAAVVNIIAPQLEIVGEEHSAPMAPEDAPSLTGMHRMGGNFQE
::: *: . . * ** *.. ::. ::. :**: . ::* * *
TH_3260|M.thermoresistible__bu GSSDSQVMIVLEGEEPLGADARAFYDELVKRLEADDAHVENVQDLWSDPL
Mvan_3189|M.vanbaalenii_PYR-1 GDSDSSVMIVFEGDQPLGDEAHAWYDELVERLRADTKHVQSVQDFWSDPL
MAB_4382c|M.abscessus_ATCC_199 FKTSSSVMIVLEGEQSLGADAHRFYDQMVRDLRADTTHVQHVQDFWADAL
Mflv_4418|M.gilvum_PYR-GCK FDSDSSAMVVLEGEQPLGDAAHRYYDQLIDELEADTANVQHIADFWGDPL
Mb0458c|M.bovis_AF2122/97 GDSDSFAMVIIEGNQPLGDAAHKYYDGLVAQLRADKKHVQSVQDLWGDPL
Rv0450c|M.tuberculosis_H37Rv GDSDSFAMVIIEGNQPLGDAAHKYYDGLVAQLRADKKHVQSVQDLWGDPL
MLBr_02378|M.leprae_Br4923 GNSDSVIMIVLEGDKPLGDDAHRFYDGLIRKLRADK-HVQSVQDFWGDPL
MMAR_3744|M.marinum_M FDSNSTVMIVLEGQHKLGDDAHQYYDSLIRQLRQDPEHIQHIQDFWGDRL
MUL_3688|M.ulcerans_Agy99 FDSNSTVMIVLEGQHKLGDDAHQYYDSLIRQLRQDPEHIQHIQDFWGDRL
MAV_1755|M.avium_104 FDSNSTVMIVLEGQQPLGPDAHKYYDNLIRQLRQDPKHIQHIQDFWGDRL
MSMEG_0576|M.smegmatis_MC2_155 FDSNSTVMVVIEGQEPLGPDAHAYYDEIIRKLRQDPEHIQHIQDFWGDTL
.:.* *:::**:. ** *: :** :: *. * ::: : *:*.* *
TH_3260|M.thermoresistible__bu TATGVQSPDGKSAYVQVKLAGNQGEALANESVETVREMIATVSEEMAPEG
Mvan_3189|M.vanbaalenii_PYR-1 TASGSQSNDGKAAYVQVKLAGNQGESLANESVQAAQEIVRSLE---PPPG
MAB_4382c|M.abscessus_ATCC_199 TAAAAQSSDGKAAYVQVYIAGDQGEALANESVEAVRHITAAVP---PSPG
Mflv_4418|M.gilvum_PYR-GCK TASGAQSTDGKAAYVQVYLQGNQGEPRANEAVAAVREIVDRTP---APPG
Mb0458c|M.bovis_AF2122/97 TAAGVQSNDGKAAYVQLSLAGNQGTPLANESVEAVRSIVESTP---APPG
Rv0450c|M.tuberculosis_H37Rv TAAGVQSNDGKAAYVQLSLAGNQGTPLANESVEAVRSIVESTP---APPG
MLBr_02378|M.leprae_Br4923 TAPGAQSNDGKAAYVQLSLAGNQGELLAQESIDAVRKIVVQTP---APPG
MMAR_3744|M.marinum_M TAAGAQSADGKSAYVMVNLAGNQGTTLANESVEAVRDVINRTH---EPAG
MUL_3688|M.ulcerans_Agy99 TAAGAQSADGKSAYVMVNLAGNQGTTLANESVEAVRDVINRTH---EPAG
MAV_1755|M.avium_104 TAAGAQSADAKGAYVQVNLAGNQGTTLANESVDAVRKVIDENK---APPG
MSMEG_0576|M.smegmatis_MC2_155 TAAGAQSADGKAAYVMLNLAGEQGQTLANDGVQEVRQVIADTP---APPG
**.. ** *.*.*** : : *:** *::.: .: : . *
TH_3260|M.thermoresistible__bu VQAFVTGGAAMSADQQEAGDSSLRVIEALTFLVITTMLLFVYRSVITVLI
Mvan_3189|M.vanbaalenii_PYR-1 VRAFVTGPAALAADQHIASDRSVRVIELVTFAVIIVMLLLVYRSIVTVLL
MAB_4382c|M.abscessus_ATCC_199 VRVYVTGPATTSADQEIVANDSMELIELVTFGVIMVMLLLVYRSVITMVI
Mflv_4418|M.gilvum_PYR-GCK IKAYVTGGAPLVADQHSAGDTSVLRVTLITIGVIAVMLLIVFRSVATMVL
Mb0458c|M.bovis_AF2122/97 IKAYVTGPSALAADMHHSGDRSMARITMVTVAVIFIMLLLVYRSIITVVL
Rv0450c|M.tuberculosis_H37Rv IKAYVTGPSALAADMHHSGDRSMARITMVTVAVIFIMLLLVYRSIITVVL
MLBr_02378|M.leprae_Br4923 ITAWVTGASALIADMHHSGDKSMIRITATSVIVILVTLLLVYRSFITVIL
MMAR_3744|M.marinum_M VKAYVTGPAALSDDMHLIGNASLAKITMFTLGAIAVMLLLVYRSIVTTVI
MUL_3688|M.ulcerans_Agy99 VKAYVTGPAALSDDMHLIGNASLATITMFTLGAIAVMLLLVYRSIVTTVI
MAV_1755|M.avium_104 VKAYVTGPAALSDDMHIIGNASLAKITLFTLGAIAIMLLLVYRSIVTTLV
MSMEG_0576|M.smegmatis_MC2_155 VQAYAAGPAALTDDLHVIGNASLGKITLFTLVAIAVMLLIVYRSIVTTLI
: .:.:* :. * . .: *: : :. .* **:*:**. * ::
TH_3260|M.thermoresistible__bu ALFMVLIGLLTTRGVVAFLGYHNIIGLSTFATSLLVTLAIAIAVDYAIFL
Mvan_3189|M.vanbaalenii_PYR-1 TLVMVVLSLATARGVVAFLGWHEIIGLSLFATNLLVTLAIAAATDYAIFL
MAB_4382c|M.abscessus_ATCC_199 VVAMVMLELASARGLVALLSYHNAFGLTSFATSLVVTLAIAAATDYAIFL
Mflv_4418|M.gilvum_PYR-GCK ILFMVFAELGAARGIVAFLADAEIIGLSTFATSLLTLMVIAAGTDYAIFA
Mb0458c|M.bovis_AF2122/97 LLITVGVELTAARGVVAVLGHSGAIGLTTFAVSLLTSLAIAAGTDYGIFI
Rv0450c|M.tuberculosis_H37Rv LLITVGVELTAARGVVAVLGHSGAIGLTTFAVSLLTSLAIAAGTDYGIFI
MLBr_02378|M.leprae_Br4923 LLFTVGIESAVARGVVALLGHTGLIGLSTFAVNLLTSLAIAAGTDYGIFI
MMAR_3744|M.marinum_M QLFMTGIALASSRGVVAVLGYHNVFGLTTFAANILTMLAIAAGTDYGIFL
MUL_3688|M.ulcerans_Agy99 QLFMTGIALASSRGVVAVLGYHNVFGLTTFAANILTMLAIAAGTDYGIFL
MAV_1755|M.avium_104 QLFMTFVALACSRGVVAVLAYHNAFGLTTFAANILTMLAIAAGTDYGIFL
MSMEG_0576|M.smegmatis_MC2_155 QLVLTGVGLLASRGLISVLATHDVFGLTTFAGNILTMLAIAAATDYGIFL
: . :**:::.*. :**: ** .::. :.** ..**.**
TH_3260|M.thermoresistible__bu IGRYQEARSVGADRATAYHTMFGGTAHVILASGLTIAGATFCLSFTRLPY
Mvan_3189|M.vanbaalenii_PYR-1 IGRYQEARTNGEDKESAYYTMFHGTAHVVLGSGLTIAGATYCLSFTRLPY
MAB_4382c|M.abscessus_ATCC_199 IGRYQEARRAGEDRESAYYTMFHGTAHVVLASGLTIAGATFCLHFTRLPY
Mflv_4418|M.gilvum_PYR-GCK IGRYQEARGAGEDRETAYYTMFRGTAHVVLGSGLTIAGAMLCLSFTRLPY
Mb0458c|M.bovis_AF2122/97 IGRYQEARQAGEDKEAAYYTMYRGTAHVILGSGLTITGATFCLSFARMPY
Rv0450c|M.tuberculosis_H37Rv IGRYQEARQAGEDKEAAYYTMYRGTAHVILGSGLTIAGATFCLSFARMPY
MLBr_02378|M.leprae_Br4923 TGRYQEARQANENKEAAFYTMYRGTFHVILGSGLTISGATFCLSFARMPY
MMAR_3744|M.marinum_M VGRYQEARQAGEDREDAYYTTFRGVAPVVLGSGLTIAGATYCLSFARLPW
MUL_3688|M.ulcerans_Agy99 VGRYQEARQAGEDRQDAYYTTFRGVAPVVLGSGLTIAGATYCLSFARLPW
MAV_1755|M.avium_104 IGRYQEALAAGEDRESAYYTTFKGVAPVVLGSGLTIAGATYCLSFSRLPW
MSMEG_0576|M.smegmatis_MC2_155 FGRYREARGAGEDPETAYYTTFKSVSPVIVGSGLTIAGATYCLSFARLPY
***:** . : *::* : .. *::.*****:** ** *:*:*:
TH_3260|M.thermoresistible__bu FQSLGPPLAIGMIVLIVTSLTMGPAIITVATRFG-LLEPKRAARVRFWRK
Mvan_3189|M.vanbaalenii_PYR-1 FQTLGVPLAIGMFVVVMAGVILMVAMISVATRFGKLLEPKRAMRIRGWRK
MAB_4382c|M.abscessus_ATCC_199 FKTTGIPLSIGMAIVVAMALTLGPALISVASRFGNVLEPKGAGKARGWRR
Mflv_4418|M.gilvum_PYR-GCK FQTMGVPCAVGTFVAVIAALTLGPAVIVIGSRFG-LFDPKRAISSRGWRR
Mb0458c|M.bovis_AF2122/97 FQTLGIPCAVGMLVAVAVALTLGPAVLHVGSRFG-LFDPKRLLKVRGWRR
Rv0450c|M.tuberculosis_H37Rv FQTLGIPCAVGMLVAVAVALTLGPAVLHVGSRFG-LFDPKRLLKVRGWRR
MLBr_02378|M.leprae_Br4923 FQTLGVPCAVGMLIAVAVALTLGPAVLTVGSRFG-LFEPKRLIKVRGWRR
MMAR_3744|M.marinum_M FNTMGAPVAIGMLVVVLAGLTLGPAVVFVGSRFHLFESKRAANRGRLWRR
MUL_3688|M.ulcerans_Agy99 FNTMGAPVAIGMLVVVLAGLTLGPAVVFVGSRFHPFESKRAANRGRLWRR
MAV_1755|M.avium_104 FNTMGAPVAIGMLVVVLAGVTLGPAVVFVGSRFHFFE--RQAKRGRLWRR
MSMEG_0576|M.smegmatis_MC2_155 FSTMGAPVAIGMIVVVASSVTMGPAVLFLGSKVGLYEAKRAAK-GRFWRR
*.: * * ::* : : .: : *:: :.::. : * **:
TH_3260|M.thermoresistible__bu VGASVVRWPGPIMVTTVAVTLVGLLALPGYRTNYNDRNYLPASFPSNAGY
Mvan_3189|M.vanbaalenii_PYR-1 IGAAVVRWPGPILVATLAITLVGLLALPGYKTNYNDRTYLPADLPANEGY
MAB_4382c|M.abscessus_ATCC_199 VGAATVRWPGAILVAAVTMALVGLLTLPGYHTTYNDRIYLPGQVPANVGY
Mflv_4418|M.gilvum_PYR-GCK IGVSVVRWPGPVLAATLALALVGLVTLPGYKTNYDARDYLPEDIPANVGY
Mb0458c|M.bovis_AF2122/97 VGTVVVRWPLPVLVATCAIALVGLLALPGYKTSYNDRDYLPDFIPANQGY
Rv0450c|M.tuberculosis_H37Rv VGTVVVRWPLPVLVATCAIALVGLLALPGYKTSYNDRDYLPDFIPANQGY
MLBr_02378|M.leprae_Br4923 IGTVVVRWPLPILITTCAIAMVGLLALPGYRTNYKDRAYLPASIPANQGF
MMAR_3744|M.marinum_M VGTAVVRWPAPILALSGAIVLVGMVALPGFKTSYNDRYYLPASAPSNLGE
MUL_3688|M.ulcerans_Agy99 VGTAVVRWPAPILALSGAIVLVGMVALPGFKTSYNDRYYLPASAPSNLGE
MAV_1755|M.avium_104 VGTAVVRWPAPVLAVSAAVVLVGMIALPSFHTSYNDRHYLPLSAPSNQGQ
MSMEG_0576|M.smegmatis_MC2_155 VGTAVVRWPAPILVASAFIVLIGVVAVPGYRPAYNDRWYLPDDAPVNIGF
:*. .**** .:: : :.::*::::*.::. *. * *** * * *
TH_3260|M.thermoresistible__bu EAAERHFDPARLNPELLLIESDHDLRNPADFLVIEKIAKAVFQVEGISRV
Mvan_3189|M.vanbaalenii_PYR-1 AVADRHFDQARMNPELLMIESDHDLRNSADFLVIDKIAKAIFKVEGIARV
MAB_4382c|M.abscessus_ATCC_199 AAADRHFSKAKMNPDLLLVESDHDLRNPADFLVIDKIAKALARVRGIAQV
Mflv_4418|M.gilvum_PYR-GCK AVADQHFGSARMNPELLMVESDHDLRNPADFLVIDKIAKSVFRVPGVARV
Mb0458c|M.bovis_AF2122/97 AAADRHFSQARMKPEILMIESDHDMRNPADFLVLDKLAKGIFRVPGISRV
Rv0450c|M.tuberculosis_H37Rv AAADRHFSQARMKPEILMIESDHDMRNPADFLVLDKLAKGIFRVPGISRV
MLBr_02378|M.leprae_Br4923 AAADRHFPQARMKPEILMIESDHDMRNPADFLILDKLARGIFRVPGISRV
MMAR_3744|M.marinum_M AAADRHFSHARMNPDMLMVEAEHDMRNPADMLVLDKVAKNVIRTVGIAMI
MUL_3688|M.ulcerans_Agy99 AAADRHFSHARMNPDMLMVEAEHDMRNPADMLVLDKVAKNVIRTVGIAMI
MAV_1755|M.avium_104 EAANRHFSEARMNPDLLMIESDHDMRNPADMLVLDRVAKNEMRTLGIAMV
MSMEG_0576|M.smegmatis_MC2_155 AAADRHFTQARMNPDILMVEADHDMRNPADMLVLDRVAKNVLRTQGIAMV
.*::** *:::*::*::*::**:**.**:*:::::*: :. *:: :
TH_3260|M.thermoresistible__bu QGITRPEGTPIEHSSIPFMISQQGTLQILNQQYMQDRMADMLVQADEMQL
Mvan_3189|M.vanbaalenii_PYR-1 QAITRPDGKPIKHTSIPFQMSMQGTTQRLNEKYMQDRMADMLVQADEMAN
MAB_4382c|M.abscessus_ATCC_199 QTITRPDGKPIKHTSIPFNMSTANTAQTLTNDYSQANFANLLKQADAMQV
Mflv_4418|M.gilvum_PYR-GCK QTITRPDGKPIKHTTIPFQMSMQGTTQRLNEKYLQDRMADMLVQADAMQT
Mb0458c|M.bovis_AF2122/97 QAITRPEGTTMDHTSIPFQISMQNAGQLQTIKYQRDRANDMLKQADEMAT
Rv0450c|M.tuberculosis_H37Rv QAITRPEGTTMDHTSIPFQISMQNAGQLQTIKYQRDRANDMLKQADEMAT
MLBr_02378|M.leprae_Br4923 QAITRPDGTAMDHTSIPFQISMQNAGQVQTMKYQKDRMNDLLRQAENMAE
MMAR_3744|M.marinum_M QDITRPLGIPIQHSSIPFQNSMQSQTMMQNMAFLKERMADMTKMADEMQV
MUL_3688|M.ulcerans_Agy99 QDITRPLGIPIQHSSIPFQNSMQSQTMMQNMAFLKERMADMTKMADEMQV
MAV_1755|M.avium_104 QDITRPLGIPIQHSSIPFQNSVQSQTTMQNMGFLKERMNDILKMADDLQT
MSMEG_0576|M.smegmatis_MC2_155 QSITRPLGIPIQHSSIPFQTAIQGQTSNLNLPFQRAQLDNQLKMVEATNQ
* **** * .:.*::*** : . . : : . : .:
TH_3260|M.thermoresistible__bu MIDTMDKMIALMEEMVETTDNMVRDMDEMAAHVAEMRDSISEFDDFFRPI
Mvan_3189|M.vanbaalenii_PYR-1 TIATMEKMSNLTAQMADITHSMVSKMENMLTDIEDLRDSIANFDDFFRPI
MAB_4382c|M.abscessus_ATCC_199 TIDSMEKMQAITQQMAEVTASMSANMKNTAQDINQLRDNMSNFDDQFRPI
Mflv_4418|M.gilvum_PYR-GCK NVDTMTRMQSLMGQMSATTHEMVLKTKKTEIDIIEVRDNLADFDDFFRPV
Mb0458c|M.bovis_AF2122/97 TIAVLTRMHSLMAEMASTTHRMVGDTEEMKEITEELRDHVADFDDFWRPI
Rv0450c|M.tuberculosis_H37Rv TIAVLTRMHSLMAEMASTTHRMVGDTEEMKEITEELRDHVADFDDFWRPI
MLBr_02378|M.leprae_Br4923 TIASMRRMHQLMALLTENTHHILNDTVEMQKTTSKLRDEIANFDDFWRPI
MMAR_3744|M.marinum_M LIDTTERMYAVMRDLDTTTTDMARVTAETSTITDELRDHLAEFDDFWRPM
MUL_3688|M.ulcerans_Agy99 LIDTTERMYAVMRELDTTTTDMARVTAETSTITDELRDHLAEFDDFWRPM
MAV_1755|M.avium_104 QIDTTQRQYEVSMDLANAADDSAKTTAVTSQITDSLRDHIADFDDTFRPI
MSMEG_0576|M.smegmatis_MC2_155 SIAIMEKQYELSLRQTKLTQDSAEKSRELLEVTKQLRDNIANFDDQFRPL
: : : : .:** :::*** :**:
TH_3260|M.thermoresistible__bu RNYFYWEPHCYNIPVCWAMRSVFDTLDGINTMTDDIQNMLPHMHRLNDLM
Mvan_3189|M.vanbaalenii_PYR-1 RNYFYWEPHCYNIPVCWALRSVFDTLDGINVMTDDFREILPDMKRLDSLM
MAB_4382c|M.abscessus_ATCC_199 RNYFYWEKHCFDIPMCWALRSVFDALDGISLMSDDFDTLVPDIQRMAGLM
Mflv_4418|M.gilvum_PYR-GCK RNYFYWEPHCYDIPVCWTMRSVFDTLDGINPLTDDISELIPDLERLDELM
Mb0458c|M.bovis_AF2122/97 RSYFYWEKHCYGIPICWSFRSIFDALDGIDKLSEQIGVLLGDLREMDRLM
Rv0450c|M.tuberculosis_H37Rv RSYFYWEKHCYGIPICWSFRSIFDALDGIDKLSEQIGVLLGDLREMDRLM
MLBr_02378|M.leprae_Br4923 RSYFYWERHCFNIPICWSFRSIFDALDGVDQIDERLNSIVGDIKNMDLLM
MMAR_3744|M.marinum_M RSYFYWEKHCFDVPICWSFRSLFDSLDGIDKLSEKFSELTEDIQHTAGLT
MUL_3688|M.ulcerans_Agy99 RSYFYWEKHCFDVPICWSFRSLFDSLDGIDKLSEKFSELTEDIQRTAGLT
MAV_1755|M.avium_104 RTYFYWEKHCYDIPVCIGLRSLFDTFDGFDQLAEQFHYLTTDIAHTAKAS
MSMEG_0576|M.smegmatis_MC2_155 RNYFYWEPHCFDIPMCAAARSLFDSLDTVDELTDRTSAVQVNTDELADLA
*.***** **:.:*:* **:**::* .. : : : . .
TH_3260|M.thermoresistible__bu PQMLTLLPTTVATMKTMRSMLLTMQATNAGLQDQMAEMQENANAMGEAFD
Mvan_3189|M.vanbaalenii_PYR-1 PQMVALMPEMIETMKTMRTMMLTMYQSQKGQQDQMAAMSEDADAMGEAFD
MAB_4382c|M.abscessus_ATCC_199 PQMVVLMPPMIASMKEQKQIMLSQYQVQKAQQDQTMAMQANASAMGQAFD
Mflv_4418|M.gilvum_PYR-GCK PQLIALLPSQIETMRSMQAMMLRQYQTQKGQLDQNAAMSEDADAMGEAFD
Mb0458c|M.bovis_AF2122/97 PQMVAQIPPQIEAMENMRTMILTMHSTMTGIFDQMLEMSDNATAMGKAFD
Rv0450c|M.tuberculosis_H37Rv PQMVAQIPPQIEAMENMRTMILTMHSTMTGIFDQMLEMSDNATAMGKAFD
MLBr_02378|M.leprae_Br4923 PQMLEQFPPMIESMESMRTIMLTMHSTMSGIFDQMNELSDNANTMGKAFD
MMAR_3744|M.marinum_M SQMLTLIPPMIATMKTTKALTLTMQSTFSAMLDQMDELSNTAIVMGQSFD
MUL_3688|M.ulcerans_Agy99 SQMLTLIPPMIATMKTTKALTLTMQSTFSAMLDQMDELSNTAIVMGQSFD
MAV_1755|M.avium_104 RDLTALFPTLITTLKTTRGITLTLYQTFKAMIDQMEAMSNTAVVMGQSFD
MSMEG_0576|M.smegmatis_MC2_155 PQLTALLPQTIASMKTSRDLSLASYNSQKALLDQMQAMNDTALAMGQSFD
:: :* : ::. : : * . ** :. * .**::**
TH_3260|M.thermoresistible__bu QARNDDSFYLPPEAFDNPDFQRGLEQFLSPDGHAVRFIISHQGDPMTPEG
Mvan_3189|M.vanbaalenii_PYR-1 DSMNDDSFYLPPEIFENKDFQRGLEQFLSPDGHAVRFIISHEGDPLSPEG
MAB_4382c|M.abscessus_ATCC_199 DAKNDDSFYLPPEAFETADFKSGIKLFVSPNGHAVRFTIFHQSDPLTEEG
Mflv_4418|M.gilvum_PYR-GCK DSMNDDSFYLPPEAFDNDDFKRGMENFISPDGRSVRFIISHEGDPATVEG
Mb0458c|M.bovis_AF2122/97 AAKNDDSFYLPPEVFKNKDFQRAMKSFLSSDGHAARFIILHRGDPQSPEG
Rv0450c|M.tuberculosis_H37Rv AAKNDDSFYLPPEVFKNKDFQRAMKSFLSSDGHAARFIILHRGDPQSPEG
MLBr_02378|M.leprae_Br4923 TAKNDDSFYLPPEVFKNTDFKRAMKSFLSSDGHAARFIILHRGDPASVAG
MMAR_3744|M.marinum_M ASKNDDFFYLPPEAFDNPDFQTGLRMFLSPDGKSARFFITHQGDPMTPEG
MUL_3688|M.ulcerans_Agy99 ASKNDDFFYLPPEAFDNPDFQTGLRMFLSPDGKSARFFITHQGDPMTPEG
MAV_1755|M.avium_104 ASKNDDFFYLPPEAFDNPDFQTGLRMFLSPDGKSARFFITHQGDPMSPEG
MSMEG_0576|M.smegmatis_MC2_155 EAKNDDFFYLPPEAFQNPDFERGLKMFLSPDGKSARMFITHQSDPATPEG
: *** ****** *.. **: .:. *:*.:*::.*: * *..** : *
TH_3260|M.thermoresistible__bu LAKIEPIKKAAVEAIKGTPLEGSRVYLGGTAAVFKDMSDGTKYDLIIAAI
Mvan_3189|M.vanbaalenii_PYR-1 VAKIDKIKTAAKEAIKGTPLEGSKIYLGGTAATFKDMQDGNNYDLLIAGI
MAB_4382c|M.abscessus_ATCC_199 TSRVEPLKTAAEDAIKGTPLEGSSIYVGGSAALYKDMQEGADYDLLIAAV
Mflv_4418|M.gilvum_PYR-GCK ISEVVPIKTAAKEAIKGTPLEGSTVYLAGTAATYKDMSDGAFYDLLIAGI
Mb0458c|M.bovis_AF2122/97 IKSIDAIRTAAEESLKGTPLEDAKIYLAGTAAVFHDISEGAQWDLLIAAI
Rv0450c|M.tuberculosis_H37Rv IKSIDAIRTAAEESLKGTPLEDAKIYLAGTAAVFHDISEGAQWDLLIAAI
MLBr_02378|M.leprae_Br4923 IASINAIRTAAEEALKGTPLEDTKIYLAGTAAVFKDIDEGANWDLVIAGI
MMAR_3744|M.marinum_M ISRVDAERTAAQEGLKQSSLSDAKVYLGGTAATFKDMADGEKYDLMIAVV
MUL_3688|M.ulcerans_Agy99 ISRVDAERTAAQEGLKQSSLSDAKVYLGGTAATFKDMADGEKYDLMIAVV
MAV_1755|M.avium_104 IKRVDAERTAAQEGLKQSSLSDARVYLGGTAATFKDMADGEKYDLMIAVV
MSMEG_0576|M.smegmatis_MC2_155 IARVNAERTAAQEGLKMSSLSDAKIFLGGTAATYKDMSDGARYDLMIAVV
: :.** :.:* :.*..: :::.*:** ::*: :* :**:** :
TH_3260|M.thermoresistible__bu AAVCLIFIIMLILTRAVVAAAVIVGTVTLSLAASFGVSVLIWQYIVGLEM
Mvan_3189|M.vanbaalenii_PYR-1 SALGLIFIIMLILTRAIVAAAVIVGTVVLSLAASFGLSVLFWQHILGTEL
MAB_4382c|M.abscessus_ATCC_199 AALILIFLIMVLLTRAVVAAAVIVGTVVLSLGASFGLSVLLWQHIIGTPL
Mflv_4418|M.gilvum_PYR-GCK AAVTLIFVIMLVITRSVVAAAVIVGTVLLSLGASFGLSVLLWQHIIGLAL
Mb0458c|M.bovis_AF2122/97 SSLCLIFIIMLIITRAFIAAAVIVGTVALSLGASFGLSVLLWQHILAIHL
Rv0450c|M.tuberculosis_H37Rv SSLCLIFIIMLIITRAFIAAAVIVGTVALSLGASFGLSVLLWQHILAIHL
MLBr_02378|M.leprae_Br4923 SSLCLIFIIMLIITRAFVAAAVIVGTVALSLGASFGLSVLLWQHILGIEL
MMAR_3744|M.marinum_M SALTLIFLIMLLLTRSVVAALVIVGTAASSIAASFGLSVLIWQDLFGIKI
MUL_3688|M.ulcerans_Agy99 SALTLIFLIMLLLTRSVVAALVIVGTAASSIAASFGLSVLIWQDLFGIKI
MAV_1755|M.avium_104 SALTLIFMIMLLLTRSVVAALVIVGTAASSIAASFGLSVLIWQDLFGIRI
MSMEG_0576|M.smegmatis_MC2_155 SALTLIFMIMLILTRSAVAALVIVGTAASSIAASFGISVLLWQDLFGVEV
::: ***:**:::**: :** *****. *:.****:***:** :.. :
TH_3260|M.thermoresistible__bu HWMVFPMALIILLAVGADYNLLVVARLREEIPAGLNTGMIRAMGGSGSVV
Mvan_3189|M.vanbaalenii_PYR-1 HWMVLAMAVIVLLAVGADYNLLLVSRLKEEIHAGIGTGIIRAMGGSGSVV
MAB_4382c|M.abscessus_ATCC_199 HWMVLPMAVIILLAVGADYNLLLVSRMKEELHAGLHTGTIRSMAGTGSVV
Mflv_4418|M.gilvum_PYR-GCK HWMVLPMAVILLLAVGSDYNLLLVSRFKEELSGGLKTGIIRAMAGTGSVV
Mb0458c|M.bovis_AF2122/97 HWLVLAMSVIVLLAVGSDYNLLLVSRFKQEIGAGLKTGIIRSMGGTGKVV
Rv0450c|M.tuberculosis_H37Rv HWLVLAMSVIVLLAVGSDYNLLLVSRFKQEIGAGLKTGIIRSMGGTGKVV
MLBr_02378|M.leprae_Br4923 HYLVLAMSVIVLLAVGSDYNLLLVSRFKQEIQAGLKTGIIRSMGGTGKVV
MMAR_3744|M.marinum_M HWIVAALSVIILLAVGSDYNLLLVSRFREEIHAGLKTGIIRSMAGTGGVV
MUL_3688|M.ulcerans_Agy99 HWIVAALSVIILLAVGSDYNLLLVSRFREEIHAGLKTGIIRSMAGTGGVV
MAV_1755|M.avium_104 HWIVAALSVIILLAVGSDYNLLLVSRFREEIHGGLKTGIIRSMAGTGGVV
MSMEG_0576|M.smegmatis_MC2_155 HWLVMLMSVIILLAVGSDYNLLLVSRFKDEIHAGLKTGIIRSMAGTGGVV
*::* :::*:*****:*****:*:*:::*: .*: ** **:*.*:* **
TH_3260|M.thermoresistible__bu TAAGLVFGLTMMVMVVSDLTVMGQVGTTIGLGLLFDTFVVRSFMMPSIAT
Mvan_3189|M.vanbaalenii_PYR-1 TAAGLVFALTMMSMAVSELTVIGQVGTTIGLGLLFDTLVIRAFMTPSIAA
MAB_4382c|M.abscessus_ATCC_199 TSAGLVFAFTMMGMMVSSFTVIGQIGTTIGLGLLFDTLVVRSFMTPSIAS
Mflv_4418|M.gilvum_PYR-GCK TSAGLVFAFTMASFAFSDLKVMAQVGTTIALGLLFDTLIVRSFMTPAVAA
Mb0458c|M.bovis_AF2122/97 TNAGLVFAVTMASMAVSDLRVIGQVGTTIGLGLLFDTLIVRSFMTPSIAA
Rv0450c|M.tuberculosis_H37Rv TNAGLVFAVTMASMAVSDLRVIGQVGTTIGLGLLFDTLIVRSFMTPSIAA
MLBr_02378|M.leprae_Br4923 TNAGLVFAFTMASMVVSDLRVIGQVGTTIGLGLLFDTLIVRSFMMPSIAA
MMAR_3744|M.marinum_M TAAGLVFAFTMASMLGSDLRVLGQFGSTVCIGLLLDTLIVRTLLMPSIAT
MUL_3688|M.ulcerans_Agy99 TAAGLVFAFTMASMLGSDLRVLGQFGSTVCIGLLLDTLIVRTLLMPSIAT
MAV_1755|M.avium_104 TAAGLVFAFTMAAMLGSELRVLGQFGSTVCIGLLLDTLIVRTLLMPSIAT
MSMEG_0576|M.smegmatis_MC2_155 TSAGLVFAATMAAMLGSELVVLAQMGSTIAIGLLLDTLIVRSLLMPSIAT
* *****. ** : *.: *:.*.*:*: :***:**:::*::: *::*:
TH_3260|M.thermoresistible__bu LLGRWFWWPQFVRKRPVPQPWPSVPPRGPATTDRVSV-----
Mvan_3189|M.vanbaalenii_PYR-1 LLGPWFWWPQRVRTRPVPAPWPRPGGLQSDPSEGVKV-----
MAB_4382c|M.abscessus_ATCC_199 LLGRWFWWPMVVRPRPRPQPWP--QPLHAGAAEAVRA-----
Mflv_4418|M.gilvum_PYR-GCK LLGRWFWWPQKFRSAASERRLARIGVQPATAGR---------
Mb0458c|M.bovis_AF2122/97 LLGRWFWWPLRVRSRPARTPTVPSETQPAGRPLAMSSDRLG-
Rv0450c|M.tuberculosis_H37Rv LLGRWFWWPLRVRSRPARTPTVPSETQPAGRPLAMSSDRLG-
MLBr_02378|M.leprae_Br4923 LLGRWFWWPQQGRTRPLLTVAAPVGLPPD-RSLVYSD-----
MMAR_3744|M.marinum_M LLGRWFWWPQVVHPRGDNARPRVAAPTH--------------
MUL_3688|M.ulcerans_Agy99 LLGRWFWWPQVVHPRGDNARPRVAAPTH--------------
MAV_1755|M.avium_104 LLGRWFWWPMVVHPRGDNARRPVPASS---------------
MSMEG_0576|M.smegmatis_MC2_155 LLGRWFWWPQVVYPRGDNHFRRPTAVSRGTGDEDTAALPVPS
*** *****