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STKFANDSNTNARPEKPFIARMIHAFAVPIILGWLAVCVVVTVFVPSLEAVGQERSVSLSPKDAPSFEAM GRIGMVFKEGDSDSFAMVIIEGNQPLGDAAHKYYDGLVAQLRADKKHVQSVQDLWGDPLTAAGVQSNDGK AAYVQLSLAGNQGTPLANESVEAVRSIVESTPAPPGIKAYVTGPSALAADMHHSGDRSMARITMVTVAVI FIMLLLVYRSIITVVLLLITVGVELTAARGVVAVLGHSGAIGLTTFAVSLLTSLAIAAGTDYGIFIIGRY QEARQAGEDKEAAYYTMYRGTAHVILGSGLTIAGATFCLSFARMPYFQTLGIPCAVGMLVAVAVALTLGP AVLHVGSRFGLFDPKRLLKVRGWRRVGTVVVRWPLPVLVATCAIALVGLLALPGYKTSYNDRDYLPDFIP ANQGYAAADRHFSQARMKPEILMIESDHDMRNPADFLVLDKLAKGIFRVPGISRVQAITRPEGTTMDHTS IPFQISMQNAGQLQTIKYQRDRANDMLKQADEMATTIAVLTRMHSLMAEMASTTHRMVGDTEEMKEITEE LRDHVADFDDFWRPIRSYFYWEKHCYGIPICWSFRSIFDALDGIDKLSEQIGVLLGDLREMDRLMPQMVA QIPPQIEAMENMRTMILTMHSTMTGIFDQMLEMSDNATAMGKAFDAAKNDDSFYLPPEVFKNKDFQRAMK SFLSSDGHAARFIILHRGDPQSPEGIKSIDAIRTAAEESLKGTPLEDAKIYLAGTAAVFHDISEGAQWDL LIAAISSLCLIFIIMLIITRAFIAAAVIVGTVALSLGASFGLSVLLWQHILAIHLHWLVLAMSVIVLLAV GSDYNLLLVSRFKQEIGAGLKTGIIRSMGGTGKVVTNAGLVFAVTMASMAVSDLRVIGQVGTTIGLGLLF DTLIVRSFMTPSIAALLGRWFWWPLRVRSRPARTPTVPSETQPAGRPLAMSSDRLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0450c | mmpL4 | - | 100% (967) | PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL4 |
| M. tuberculosis H37Rv | Rv0676c | mmpL5 | 0.0 | 65.41% (931) | transmembrane transport protein MmpL5 |
| M. tuberculosis H37Rv | Rv2339 | mmpL9 | 0.0 | 61.64% (941) | transmembrane transport protein MmpL9 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0458c | mmpL4 | 0.0 | 99.90% (967) | transmembrane transport protein MmpL4 |
| M. gilvum PYR-GCK | Mflv_3435 | - | 0.0 | 65.70% (933) | transport protein |
| M. leprae Br4923 | MLBr_02378 | - | 0.0 | 78.83% (954) | hypothetical protein MLBr_02378 |
| M. abscessus ATCC 19977 | MAB_2301 | - | 0.0 | 62.75% (953) | putative membrane protein, mmpL |
| M. marinum M | MMAR_0771 | mmpL5_2 | 0.0 | 81.76% (965) | transmembrane transport protein MmpL5_2 |
| M. avium 104 | MAV_2510 | - | 0.0 | 65.44% (952) | MmpL4 protein |
| M. smegmatis MC2 155 | MSMEG_0382 | - | 0.0 | 62.93% (963) | putative transport protein |
| M. thermoresistible (build 8) | TH_3056 | - | 0.0 | 62.76% (948) | PUTATIVE Mmp14a protein |
| M. ulcerans Agy99 | MUL_0757 | mmpL5 | 0.0 | 64.76% (942) | transmembrane transport protein, MmpL5 |
| M. vanbaalenii PYR-1 | Mvan_3189 | - | 0.0 | 66.27% (934) | transport protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0450c|M.tuberculosis_H37Rv MSTKFANDSN----TNARPEKPFIARMIHAFAVPIILGWLAVCVVVT---
Mb0458c|M.bovis_AF2122/97 MSTKFANDSN----TNARPEKPFIARMIHAFAVPIILGWLAVCVVVT---
MMAR_0771|M.marinum_M MTVKYANDPD----TRTHTEKPFLARMIHAFAVPIILAWVAVCVALS---
MLBr_02378|M.leprae_Br4923 MTVKCANDLD----THTKP--PFVARMIHRFAVPIILVWLAIAVTVS---
Mflv_3435|M.gilvum_PYR-GCK MSAPVSDARTDEFPAAHGPHRSFIPRMIRLFAVPIILGWIALIVVVN---
Mvan_3189|M.vanbaalenii_PYR-1 MSAPVSDARTDEFPAARQPHRPFIPRMIRLFAVPIILGWIALIVILN---
MUL_0757|M.ulcerans_Agy99 MTATTTDTPTDVVPPAEHPPRPFIPRMIRTFAVPLILGWVLLIAVLN---
MAV_2510|M.avium_104 MSTTFDDTRTDAIPVVKEPVREKIPRFIRAFAVPIIIGWIALIAVLN---
MAB_2301|M.abscessus_ATCC_1997 MSGSHAGR------SAAEP--TFLAKWIRRLSIPIVIGWLAIVFALN---
MSMEG_0382|M.smegmatis_MC2_155 MSTEQSGT--------EKARRPFFARAVRTLSPFIIVGWLAVILVTTLAA
TH_3056|M.thermoresistible__bu MSVLDRVG--------VEPRRPRVASFIRRYSVLIILGWVALTVLAT---
*: . .. :: : ::: *: : .
Rv0450c|M.tuberculosis_H37Rv ------VFVPSLEAVGQERSVSLSPKDAPSFEAMGRIGMVFKEGDSDSFA
Mb0458c|M.bovis_AF2122/97 ------VFVPSLEAVGQERSVSLSPKDAPSFEAMGRIGMVFKEGDSDSFA
MMAR_0771|M.marinum_M ------VFIPSLEVVGQERSVSLSPKDAPSYEAMKRIGAAFNEGNSDSQA
MLBr_02378|M.leprae_Br4923 ------VFIPSLEDVGQERSVSLSPKDAPSYIAMQKMGQVFNEGNSDSVI
Mflv_3435|M.gilvum_PYR-GCK ------VTVPQLETVGEAQAVSMSPNDAPSMISMKKVGELFEEGDSDSSV
Mvan_3189|M.vanbaalenii_PYR-1 ------VTVPQLEAVGEARAVSMSPNEAPSLISMKKVGELFREGDSDSSV
MUL_0757|M.ulcerans_Agy99 ------SVVPQLEVVGQMQAVSMSPDAAPSMISMKHIGKVFREGDSDSAA
MAV_2510|M.avium_104 ------VVVPQLDEVGKMRSVEMTPDDAQSVVATKRMGAVFNEYKSNSSV
MAB_2301|M.abscessus_ATCC_1997 ------TFVPQLEQVGKEHTVSLSPQSAPSMQAMKHMGKMFKESDSDSVV
MSMEG_0382|M.smegmatis_MC2_155 VGGDWSAAIPALERVGEKNSVSLMPQDAPSAKAMKHMGQKFEESDSDSFA
TH_3056|M.thermoresistible__bu ------VAVPPLEAVEREKSLSLIPYDAPAFAAMHRMGELFDEPDSESIA
:* *: * . .::.: * * : : ::* * * .*:*
Rv0450c|M.tuberculosis_H37Rv MVIIEGNQPLGDAAHKYYDGLVAQLRADKKHVQSVQDLWGDPLTAAGVQS
Mb0458c|M.bovis_AF2122/97 MVIIEGNQPLGDAAHKYYDGLVAQLRADKKHVQSVQDLWGDPLTAAGVQS
MMAR_0771|M.marinum_M MIVLEGKDALGDDAHKYYDVLIRKLRADPRHVQSVQDFWGDPLTAAGAQS
MLBr_02378|M.leprae_Br4923 MIVLEGDKPLGDDAHRFYDGLIRKLRAD-KHVQSVQDFWGDPLTAPGAQS
Mflv_3435|M.gilvum_PYR-GCK MIVFEGDQPLGDEAHAWYDELVDRLEADTAHVQSVQDFWSDPLTASGSQS
Mvan_3189|M.vanbaalenii_PYR-1 MIVFEGDQPLGDEAHAWYDELVERLRADTKHVQSVQDFWSDPLTASGSQS
MUL_0757|M.ulcerans_Agy99 MIVLEGQEPLGAAAHKFYDKMITKLRADTKHVQSVQDFWGDPLTATGAQS
MAV_2510|M.avium_104 MIVLEGQQPLGADAHAYYDEIVRRLNADTKHVEHVQDMWSDPLTGAGAQS
MAB_2301|M.abscessus_ATCC_1997 MIVLEGQERLGPGSHKFYDEMVARLRADTKHVQHVQDFWGDPLTEAGAQS
MSMEG_0382|M.smegmatis_MC2_155 MIVLEGQEPLGPDALDYYTGLISELRNDSKHVEHVQDLWGDRLTASSAQS
TH_3056|M.thermoresistible__bu IIVLEGQEPLGLEAHEYYDQLISQLREHPQYVQHIRDFWGDPLTAGAAQS
::::**.. ** : :* :: .*. . :*: ::*:*.* ** . **
Rv0450c|M.tuberculosis_H37Rv NDGKAAYVQLSLAGNQGTPLANESVEAVRSIVESTPA---------PPGI
Mb0458c|M.bovis_AF2122/97 NDGKAAYVQLSLAGNQGTPLANESVEAVRSIVESTPA---------PPGI
MMAR_0771|M.marinum_M NDGKAAYVQLNLAGNQGEPLANESVEAVRKIVKETPA---------PPGV
MLBr_02378|M.leprae_Br4923 NDGKAAYVQLSLAGNQGELLAQESIDAVRKIVVQTPA---------PPGI
Mflv_3435|M.gilvum_PYR-GCK NDGKAAYVQVKLSGNQGEALANESVKAVQQTVSSLEP---------PPGV
Mvan_3189|M.vanbaalenii_PYR-1 NDGKAAYVQVKLAGNQGESLANESVQAAQEIVRSLEP---------PPGV
MUL_0757|M.ulcerans_Agy99 GDGKAAYVQVKLAGNQGESLANESVEAVKTIVDSLQA---------PPGV
MAV_2510|M.avium_104 NDGKASYVQVYLAGNQGEALANESVESVQNIVKSVQA---------PNGV
MAB_2301|M.abscessus_ATCC_1997 TDGKATYVQVNLAGNMGETLSNESTEAARNIVKQLEADWTKDGNKLPDGL
MSMEG_0382|M.smegmatis_MC2_155 ADGKAAYVQLNLAGNQGTPLGDESVAAVRDLVARTPA---------PEGV
TH_3056|M.thermoresistible__bu DDGKAAFVQVNLVGRFGQAKVNEAVRAVQEIVERTPA---------PEGV
****::**: * *. * :*: :.: * . * *:
Rv0450c|M.tuberculosis_H37Rv KAYVTGPSALAADMHHSGDRSMARITMVTVAVIFIMLLLVYRSIITVVLL
Mb0458c|M.bovis_AF2122/97 KAYVTGPSALAADMHHSGDRSMARITMVTVAVIFIMLLLVYRSIITVVLL
MMAR_0771|M.marinum_M TTYVTGAAALVSDMHSSGDKSMIKITVTTVAVIFIMLLLVYRSVITVVVL
MLBr_02378|M.leprae_Br4923 TAWVTGASALIADMHHSGDKSMIRITATSVIVILVTLLLVYRSFITVILL
Mflv_3435|M.gilvum_PYR-GCK RAFVTGPAALAADQHIAGDRSMRLIEAATFTVIIVMLLLVYRSIVTVLIT
Mvan_3189|M.vanbaalenii_PYR-1 RAFVTGPAALAADQHIASDRSVRVIELVTFAVIIVMLLLVYRSIVTVLLT
MUL_0757|M.ulcerans_Agy99 KVYVTGSAALVADQQLAGDRSLQLIEMVTFTVIIVMLLLVYRSIITAAIM
MAV_2510|M.avium_104 KAYVTGPAALSADQHTAGDRSLQLITAATFTVIIGMLLLVYRSVITVLLT
MAB_2301|M.abscessus_ATCC_1997 TVYVTGPGALQTDMNHAGDGSLQLITGLTFLVIVVMLLFFYRSIFTVIMV
MSMEG_0382|M.smegmatis_MC2_155 SVYVTGAAPLVSDMQHSGNRSILKITAVTVVIIFAMLLMVYRSVITVILL
TH_3056|M.thermoresistible__bu ETFVTGPAALGADAGDSGTATVILITLVTVAVIFLMLLFFFRSFLTVIVL
.:***...* :* :. :: * :. :*. **:.:**..*. :
Rv0450c|M.tuberculosis_H37Rv LITVGVELTAARGVVAVLGHSGAIGLTTFAVSLLTSLAIAAGTDYGIFII
Mb0458c|M.bovis_AF2122/97 LITVGVELTAARGVVAVLGHSGAIGLTTFAVSLLTSLAIAAGTDYGIFII
MMAR_0771|M.marinum_M LLTVGVELTAARGVVALLGHSGAIGLSTFAVSLLTSLAIAAGTDYGIFIF
MLBr_02378|M.leprae_Br4923 LFTVGIESAVARGVVALLGHTGLIGLSTFAVNLLTSLAIAAGTDYGIFIT
Mflv_3435|M.gilvum_PYR-GCK LVMVVMSLATARGVVAFLGHHEIIGLSTFATNLLVTLAIAAATDYAIFLI
Mvan_3189|M.vanbaalenii_PYR-1 LVMVVLSLATARGVVAFLGWHEIIGLSLFATNLLVTLAIAAATDYAIFLI
MUL_0757|M.ulcerans_Agy99 LTMVVLGLLATRGGVAFLGYHRIIGLSTFATNLLVVLAIAAATDYAIFLI
MAV_2510|M.avium_104 LVMVVLELSAARGMVAFLGYYKIIGLSTFATNLLVTLAIAAATDYAIFLI
MAB_2301|M.abscessus_ATCC_1997 FMLVGIQLSAARGVIAFLGNTEIIGLSTFAVNLLVMLSIAAGTDYAIFLI
MSMEG_0382|M.smegmatis_MC2_155 LIMVGFEVAAARGIVAFLGANEVFVLSTFAVNMLVFLAIAAGTDYGIFFF
TH_3056|M.thermoresistible__bu LLTVAVELQVARGLVAYLGLQGWVGLTTYVVNLLVSVGIAAGTDYGIFFF
: * . .:** :* ** . *: :...:*. :.***.***.**:
Rv0450c|M.tuberculosis_H37Rv GRYQEARQAGEDKEAAYYTMYRGTAHVILGSGLTIAGATFCLSFARMPYF
Mb0458c|M.bovis_AF2122/97 GRYQEARQAGEDKEAAYYTMYRGTAHVILGSGLTITGATFCLSFARMPYF
MMAR_0771|M.marinum_M GRYQEARQAGEDKETAFYTMYRGTAHVILGSGLTIAGATFCLKFARMPYF
MLBr_02378|M.leprae_Br4923 GRYQEARQANENKEAAFYTMYRGTFHVILGSGLTISGATFCLSFARMPYF
Mflv_3435|M.gilvum_PYR-GCK GRYQEARTAGEDKETAYYTMFHGTAHVVLGSGLTIAGATFCLSFTRLPYF
Mvan_3189|M.vanbaalenii_PYR-1 GRYQEARTNGEDKESAYYTMFHGTAHVVLGSGLTIAGATYCLSFTRLPYF
MUL_0757|M.ulcerans_Agy99 GRYQEARGLGQDRESAYYTMFGGTAHVVLGSGLTIAGATFCLSFTRLPYF
MAV_2510|M.avium_104 GRYQEARAVGESREDAYYTMYKGTAHVVAGSGMTIAGATFCLHFTNLPYF
MAB_2301|M.abscessus_ATCC_1997 GRYQEARAMGADKEAAYYEMFHGTAHVILGSGMTIAGAMYCLSFTRMPYF
MSMEG_0382|M.smegmatis_MC2_155 GRYQEARAAGEDRETAYYSMYRGVTPVVMASGLTIAGAIFCLTFTRLPYF
TH_3056|M.thermoresistible__bu GRYQEAREAGEDRDSAYFTTYRSVAKVVLASGLTIAGAIACLSFTRLPHF
******* . .:: *:: : .. *: .**:**:** ** *:.:*:*
Rv0450c|M.tuberculosis_H37Rv QTLGIPCAVGMLVAVAVALTLGPAVLHVGSRFG-LFDPKRLLKVRGWRRV
Mb0458c|M.bovis_AF2122/97 QTLGIPCAVGMLVAVAVALTLGPAVLHVGSRFG-LFDPKRLLKVRGWRRV
MMAR_0771|M.marinum_M ETLGIPCAVGMLVAVMVALTLGPAVLTVGSRFG-LFDPKRLIKVRGWRRV
MLBr_02378|M.leprae_Br4923 QTLGVPCAVGMLIAVAVALTLGPAVLTVGSRFG-LFEPKRLIKVRGWRRI
Mflv_3435|M.gilvum_PYR-GCK QTMGVPLAIGMFVVVMAGVVLMVACISVATRFGKLLEPKRAMRIRGWRKI
Mvan_3189|M.vanbaalenii_PYR-1 QTLGVPLAIGMFVVVMAGVILMVAMISVATRFGKLLEPKRAMRIRGWRKI
MUL_0757|M.ulcerans_Agy99 QTLGVPLAIGMVIVVATALTLGPALIAVMSRFGKLLEPKRMARVRGWRKI
MAV_2510|M.avium_104 QTLGIPLAIGMVVVVAAALTLGPAVISVASRFRQTLEPRRTQRIRGWRKV
MAB_2301|M.abscessus_ATCC_1997 QTLGVPCSVGLLVGVLVSLTLGPALITIGSRFG-LFEPKRAMRIRSWRKI
MSMEG_0382|M.smegmatis_MC2_155 HTMGVPCAIGMLAAVAVAVTLVPAGVALAGRIG-WLEPKRKMRVRRWRGI
TH_3056|M.thermoresistible__bu QPLGIPGAVGLLVAVAVALTLVPATIALGSRFG-LFEPKRRVMTHRWRRI
..:*:* ::*:. * ..: * * : : *: ::*:* : ** :
Rv0450c|M.tuberculosis_H37Rv GTVVVRWPLPVLVATCAIALVGLLALPGYKTSYNDRDYLPDFIPANQGYA
Mb0458c|M.bovis_AF2122/97 GTVVVRWPLPVLVATCAIALVGLLALPGYKTSYNDRDYLPDFIPANQGYA
MMAR_0771|M.marinum_M GTVVVRWPLPVLAATLAVALVGLLALPGYRTNYNDRDYLPNFIPANQGFT
MLBr_02378|M.leprae_Br4923 GTVVVRWPLPILITTCAIAMVGLLALPGYRTNYKDRAYLPASIPANQGFA
Mflv_3435|M.gilvum_PYR-GCK GAAIVRWPGPILVATMAITLVGLLALPGYKTNYNDRDYLPADLPANQGYA
Mvan_3189|M.vanbaalenii_PYR-1 GAAVVRWPGPILVATLAITLVGLLALPGYKTNYNDRTYLPADLPANEGYA
MUL_0757|M.ulcerans_Agy99 GAAIVRWPGPILIGAVALALVGLLTLPGYKTNYNDRNYLPADLPANEGYS
MAV_2510|M.avium_104 GTVVVRWPGPILVLTIGVALVGLLTLPGYRTNYNDRNYLPTDLPANEGYA
MAB_2301|M.abscessus_ATCC_1997 GTTIVRWPGPVLAAAMAIAIIGLAALPGYRTSYDDKKYIPKDIPANAGFQ
MSMEG_0382|M.smegmatis_MC2_155 GTAIVRWPAPILVASLAVALVGLLALPGYETSYNDRDYIPADIPANAGFA
TH_3056|M.thermoresistible__bu GTAVVRWPVPILTAAVALSLVGLLTLPGYNPSYSDQEFIPDDIPASEGYK
*:.:**** *:* : .::::** :****...*.*: ::* :**. *:
Rv0450c|M.tuberculosis_H37Rv AADRHFSQARMK-PEILMIESDHDMRNPADFLVLDKLAKGIFRVPGISRV
Mb0458c|M.bovis_AF2122/97 AADRHFSQARMK-PEILMIESDHDMRNPADFLVLDKLAKGIFRVPGISRV
MMAR_0771|M.marinum_M AAERHFSQARMK-PDILMIQSDHDMRNPADFLVLDRLAKGIFHVPGISRV
MLBr_02378|M.leprae_Br4923 AADRHFPQARMK-PEILMIESDHDMRNPADFLILDKLARGIFRVPGISRV
Mflv_3435|M.gilvum_PYR-GCK VADEHFDQARMN-PELLMIESDHDLRNSADFLVIDKIAKALFRVEGIARV
Mvan_3189|M.vanbaalenii_PYR-1 VADRHFDQARMN-PELLMIESDHDLRNSADFLVIDKIAKAIFKVEGIARV
MUL_0757|M.ulcerans_Agy99 AAERHFSQARMN-PEVLMVESDHDMRNSSDFLVINKIAKAIFGVEGISRV
MAV_2510|M.avium_104 AADRHFSQARMN-PEVLMIESDHDLRNSADFLVIDKIAKTVFRVPGIGRV
MAB_2301|M.abscessus_ATCC_1997 AADRHFSQARMN-PEMLLIESDHDMRNSADFLVIDKIAKAVFRVPGIARV
MSMEG_0382|M.smegmatis_MC2_155 AADRHFSQARMT-PDILMVESDHDMRNPTDFLVLNKIAKAIFKVRGVSRV
TH_3056|M.thermoresistible__bu AAARHFPASAMSVPDVVLIEADRDMRNPADLLVLNKVAKKIFEVPGVANV
.* .** : *. *:::::::*:*:**.:*:*:::::*: :* * *:..*
Rv0450c|M.tuberculosis_H37Rv QAITRPEGTTMDHTSIPFQISMQNAGQLQTIKYQRDRANDMLKQADEMAT
Mb0458c|M.bovis_AF2122/97 QAITRPEGTTMDHTSIPFQISMQNAGQLQTIKYQRDRANDMLKQADEMAT
MMAR_0771|M.marinum_M QAITRPDGTAMDHTSIPFQISMQNAGQIQTLKYQRDRMNDMLTQAEEMAK
MLBr_02378|M.leprae_Br4923 QAITRPDGTAMDHTSIPFQISMQNAGQVQTMKYQKDRMNDLLRQAENMAE
Mflv_3435|M.gilvum_PYR-GCK QAITRPDGKPIKHTSIPFQMSMQGTTQRLNEKYMQDRMADMLVQADEMAN
Mvan_3189|M.vanbaalenii_PYR-1 QAITRPDGKPIKHTSIPFQMSMQGTTQRLNEKYMQDRMADMLVQADEMAN
MUL_0757|M.ulcerans_Agy99 QAITRPDGKPIEHTSIPFLISMQGTSQKLTEKYNQDLTTSMLQQVNDIQT
MAV_2510|M.avium_104 QAITRPQGTPIEHTSIPFQISMQGVTQQMNQKYQQDQMADMLHQADMMQT
MAB_2301|M.abscessus_ATCC_1997 QAITRPQGTPIEHSSIPFLISMQSVGQRQNMKLMKDRMADMKVQADKMGE
MSMEG_0382|M.smegmatis_MC2_155 QGITRPEGTPIERTSIPFLLSLQSAGQVQATNFQKQRIGDMLKQVDDMNM
TH_3056|M.thermoresistible__bu QSVTRPEGRQIEHTTIPFMLSMSQASQRLALPFQRARMDDMLKQADELTE
*.:***:* :.:::*** :*:. . * : .: *.: :
Rv0450c|M.tuberculosis_H37Rv TIAVLTRMHSLMAEMASTTHRMVGDTEEMKEITEELRDHVADFDDFWRPI
Mb0458c|M.bovis_AF2122/97 TIAVLTRMHSLMAEMASTTHRMVGDTEEMKEITEELRDHVADFDDFWRPI
MMAR_0771|M.marinum_M TIALMRRMYGLMTQLANNTHKMVGDTIEMQQITKELRDHIANFDDFFRPI
MLBr_02378|M.leprae_Br4923 TIASMRRMHQLMALLTENTHHILNDTVEMQKTTSKLRDEIANFDDFWRPI
Mflv_3435|M.gilvum_PYR-GCK TIKTMEKMSGLTAQMADITHSMVTKMEGMVVDIEDLRDSIANFDDFFRPI
Mvan_3189|M.vanbaalenii_PYR-1 TIATMEKMSNLTAQMADITHSMVSKMENMLTDIEDLRDSIANFDDFFRPI
MUL_0757|M.ulcerans_Agy99 NIDQMERMHDLTQQMADVTHQMVIQMKGMVVDVEELRNHIADFDDFFRPI
MAV_2510|M.avium_104 TIDSMEKMQSITVQMSNDMHVMVQKMHDMTIDINDLRNKMADFEDFFRPM
MAB_2301|M.abscessus_ATCC_1997 NVVIMKRTLANMTTMAGITHSLVGDMHTLQGTIHEMRDSISNFDDWFRPI
MSMEG_0382|M.smegmatis_MC2_155 MIGVMKTTYGVLQELAATTHSLNGSTHELRDVARDLRGSIAIFDDLLRPI
TH_3056|M.thermoresistible__bu TIALMRRMQSLMEKMVATTHSMVGTTHELLDTTRDLRDHIADFDDFFRPI
: : : * : : .:*. :: *:* **:
Rv0450c|M.tuberculosis_H37Rv RSYFYWEKHCYGIPICWSFRSIFDALDGIDKLSEQIGVLLGDLREMDRLM
Mb0458c|M.bovis_AF2122/97 RSYFYWEKHCYGIPICWSFRSIFDALDGIDKLSEQIGVLLGDLREMDRLM
MMAR_0771|M.marinum_M RSYFYWEKHCYDIPICSSFRSIFDALDGIDQIDEKLDNLVVDIKELDRLM
MLBr_02378|M.leprae_Br4923 RSYFYWERHCFNIPICWSFRSIFDALDGVDQIDERLNSIVGDIKNMDLLM
Mflv_3435|M.gilvum_PYR-GCK RNYFYWEPHCYNIPVCWALRSVFDTLDGINIMTDDFKAIIPDMKRLDTLM
Mvan_3189|M.vanbaalenii_PYR-1 RNYFYWEPHCYNIPVCWALRSVFDTLDGINVMTDDFREILPDMKRLDSLM
MUL_0757|M.ulcerans_Agy99 RSYFYWEKHCFDIPVCWSLRSVFDTLDGVDLMTEDINNLLPLMERLDTLM
MAV_2510|M.avium_104 RSYFYWEKHCYDIPVCWSLRSVFDALDGIDTMTDDIQSLLPIMDHLDTLM
MAB_2301|M.abscessus_ATCC_1997 RNYLYWEKHCFDIPMCWAMRSIFDTLDKIDEMTETMDGMVVNMERMDTLM
MSMEG_0382|M.smegmatis_MC2_155 RNYFYWEPHCYNIPICWSLRSIFDAMDGVDRLNDELQVLVDNMDRLDALV
TH_3056|M.thermoresistible__bu RNYFHWEPHCYNIPICWSIRSIFDALDGINEMTEKMEELVEDMDRLDALM
*.*::** **:.**:* ::**:**::* :: : : : :: : .:* *:
Rv0450c|M.tuberculosis_H37Rv PQMVAQIPPQIEAMENMRTMILTMHSTMTGIFDQMLEMSDNATAMGKAFD
Mb0458c|M.bovis_AF2122/97 PQMVAQIPPQIEAMENMRTMILTMHSTMTGIFDQMLEMSDNATAMGKAFD
MMAR_0771|M.marinum_M PQMIETFPPMIETMESMRLMMLTMHSTMSGLYDQMSEMSENANAMGKAFD
MLBr_02378|M.leprae_Br4923 PQMLEQFPPMIESMESMRTIMLTMHSTMSGIFDQMNELSDNANTMGKAFD
Mflv_3435|M.gilvum_PYR-GCK PQMVALMPEMIETMKTMRTMMLTMYQSQKGQQDQMAAMSEDADAMGEAFD
Mvan_3189|M.vanbaalenii_PYR-1 PQMVALMPEMIETMKTMRTMMLTMYQSQKGQQDQMAAMSEDADAMGEAFD
MUL_0757|M.ulcerans_Agy99 PQMTAMMPEMIQTMKSMKAQMLSMHSTQQGLQDQMAAMQEDSSAMGEAFD
MAV_2510|M.avium_104 PQMVALMPSMIENMKAMKTTMLTMYSTQKGLQDQQNEAQKNSNAMGKAFD
MAB_2301|M.abscessus_ATCC_1997 PKMVSDMSAMIPIMEDMQRMMLTQHSTMSGFYNQMDEMSQNSTAMGKAFD
MSMEG_0382|M.smegmatis_MC2_155 PELVAQFPEYIASMETFRELTLTSYSTFSGLLQQMDEQTEDVTAMGQAFD
TH_3056|M.thermoresistible__bu PQMLVQFPQMIETMESSRTMILTMHATMSGIFDQMESSSENATAMGKAFD
*:: :. * *: : *: : : * :* .: :**:***
Rv0450c|M.tuberculosis_H37Rv AAKNDDSFYLPPEVFKNKDFQRAMKSFLSSDGHAARFIILHRGDPQSPEG
Mb0458c|M.bovis_AF2122/97 AAKNDDSFYLPPEVFKNKDFQRAMKSFLSSDGHAARFIILHRGDPQSPEG
MMAR_0771|M.marinum_M AAKNDDSFYLPPEVFKNEDFKRAMKSFLSPDGHAARFIILHRGDPQSAQG
MLBr_02378|M.leprae_Br4923 TAKNDDSFYLPPEVFKNTDFKRAMKSFLSSDGHAARFIILHRGDPASVAG
Mflv_3435|M.gilvum_PYR-GCK DSMNDDSFYLPPEIFENADFQRGLEQFLSPDGHAVRFIISHEGDPLSPEG
Mvan_3189|M.vanbaalenii_PYR-1 DSMNDDSFYLPPEIFENKDFQRGLEQFLSPDGHAVRFIISHEGDPLSPEG
MUL_0757|M.ulcerans_Agy99 SSRNDDSFYLPPEVFNNPDFKRGLEQFLSPDGHAVRFIISHEGDPMSQAG
MAV_2510|M.avium_104 ASKNDDSFYLPPETFNNKEFKKGMKNFISPDGHAVRFIISHDGDPMTQEG
MAB_2301|M.abscessus_ATCC_1997 AAKNDDSFYLPPEIFDNADFKRGMKSFLSPDGKAVRMIISHRGDPATPEG
MSMEG_0382|M.smegmatis_MC2_155 AAKNDDTFFLPPEVFDNPDFKRAMTSFLSPDGKAARFIISHNGDPATPEG
TH_3056|M.thermoresistible__bu ASHNDDSFYLPPEALENKDFQRVMEIFLSPDGKAARMLVTQRGDPATPEG
: ***:*:**** :.* :*:: : *:*.**:*.*::: : *** : *
Rv0450c|M.tuberculosis_H37Rv IKSIDAIRTAAEESLKGTPLEDAKIYLAGTAAVFHDISEGAQWDLLIAAI
Mb0458c|M.bovis_AF2122/97 IKSIDAIRTAAEESLKGTPLEDAKIYLAGTAAVFHDISEGAQWDLLIAAI
MMAR_0771|M.marinum_M IASIDQIRTAAEESLKGTPLEDAKIYVAGTASVFKDISEGADWDLLIAGI
MLBr_02378|M.leprae_Br4923 IASINAIRTAAEEALKGTPLEDTKIYLAGTAAVFKDIDEGANWDLVIAGI
Mflv_3435|M.gilvum_PYR-GCK VAKIDKIKTAAKEAVKGTPLEGSKIYLGGTAAVFKDMQDGNNYDLLIAGI
Mvan_3189|M.vanbaalenii_PYR-1 VAKIDKIKTAAKEAIKGTPLEGSKIYLGGTAATFKDMQDGNNYDLLIAGI
MUL_0757|M.ulcerans_Agy99 INHIDKIKTAAKEAIKGTPLEGSTIYLGGTVAMFKDLSDGNTFDLMIAGI
MAV_2510|M.avium_104 ISHIGAIKKAAYEALKGTPLEGSKIYLAGTASIYKDLSDGNNYDLLIAGI
MAB_2301|M.abscessus_ATCC_1997 LSHVEPIKQAAIEAVKGTPLEDAKIELGGTAAVFKDMSDGAKYDLMIAGI
MSMEG_0382|M.smegmatis_MC2_155 ISRVDQMQTAAVEALKGTPLTDAQVYLAGTAPTAKDWKDGSTYDLLIAGI
TH_3056|M.thermoresistible__bu MALVEPIYIAAEEALKGTPLESSRIYLAGSAAGVKDLVEGAKYDLMIAAI
: : : ** *::***** .: : :.*:.. :* :* :**:**.*
Rv0450c|M.tuberculosis_H37Rv SSLCLIFIIMLIITRAFIAAAVIVGTVALSLGASFGLSVLLWQHILAIHL
Mb0458c|M.bovis_AF2122/97 SSLCLIFIIMLIITRAFIAAAVIVGTVALSLGASFGLSVLLWQHILAIHL
MMAR_0771|M.marinum_M SSLCLIFIIMLILTRAFVAAAVIVGTVALSLGASFGMSVLLWQHILNIDL
MLBr_02378|M.leprae_Br4923 SSLCLIFIIMLIITRAFVAAAVIVGTVALSLGASFGLSVLLWQHILGIEL
Mflv_3435|M.gilvum_PYR-GCK AALGLIFIIMLILTRAVVAAAVIVGTVVLSLAASFGLSVLFWQHILGQPL
Mvan_3189|M.vanbaalenii_PYR-1 SALGLIFIIMLILTRAIVAAAVIVGTVVLSLAASFGLSVLFWQHILGTEL
MUL_0757|M.ulcerans_Agy99 SALCLIFIIMLIITRSVVAAAVIVGTVVLSLGASFGLSVLIWQHVLGIEL
MAV_2510|M.avium_104 SSLCLIFIIMLIITRGVVASAVIVGTVLLSLGASFGLSVLIWQHLIGIEL
MAB_2301|M.abscessus_ATCC_1997 SALCLIFLIMLLITRSFVASLVIVGTVALSLGASFGLSVIIWQYILGIEL
MSMEG_0382|M.smegmatis_MC2_155 AAMCLIFIIMLIVTRSFIAALVIVGTVVLSLGASFGLSVLLWQYILGIHL
TH_3056|M.thermoresistible__bu SAVCLIFMIMVFMTRSVIAALVIVGTVVLSLGASFGMSVLLWQHLLGIQL
::: ***:**:::**..:*: ****** ***.****:**::**::: *
Rv0450c|M.tuberculosis_H37Rv HWLVLAMSVIVLLAVGSDYNLLLVSRFKQEIGAGLKTGIIRSMGGTGKVV
Mb0458c|M.bovis_AF2122/97 HWLVLAMSVIVLLAVGSDYNLLLVSRFKQEIGAGLKTGIIRSMGGTGKVV
MMAR_0771|M.marinum_M HYMVLAMSVIVLLAVGSDYNLLLVSRFKEEIPAGLKTGIIRAMGGTGKVV
MLBr_02378|M.leprae_Br4923 HYLVLAMSVIVLLAVGSDYNLLLVSRFKQEIQAGLKTGIIRSMGGTGKVV
Mflv_3435|M.gilvum_PYR-GCK HWMVLAMAVIILLAVGADYNLLLVSRLKEEIHAGIGTGIIRAMGGSGSVV
Mvan_3189|M.vanbaalenii_PYR-1 HWMVLAMAVIVLLAVGADYNLLLVSRLKEEIHAGIGTGIIRAMGGSGSVV
MUL_0757|M.ulcerans_Agy99 HWLVLAMAVIILLAVGADYNLLLVARLKEEIHAGINTGIIRAMGGSGSVV
MAV_2510|M.avium_104 HWMVLAMSVIILLAVGADYNLLLVARFKEEIHAGLNTGIIRSMGGTGSVV
MAB_2301|M.abscessus_ATCC_1997 HWLVMQMAIIVLLAVGSDYNLLLVSRLKEELHGGLKTGIIRSMGGTGSVV
MSMEG_0382|M.smegmatis_MC2_155 HWMVLAMSVIILLAVGSDYNLLLVSRIKEEVGAGINTGIVRAMGGTGKVV
TH_3056|M.thermoresistible__bu HWVVLAMSVIVLLAVGSDYNLMLVSRMKEEIGAGLNTGIIRAMGGTGRVV
*::*: *::*:*****:****:**:*:*:*: .*: ***:*:***:* **
Rv0450c|M.tuberculosis_H37Rv TNAGLVFAVTMASMAVSDLRVIGQVGTTIGLGLLFDTLIVRSFMTPSIAA
Mb0458c|M.bovis_AF2122/97 TNAGLVFAVTMASMAVSDLRVIGQVGTTIGLGLLFDTLIVRSFMTPSIAA
MMAR_0771|M.marinum_M TNAGLVFAFTMASMAVSDLRVIGQVGTTIGLGLLFDTLIVRAFMTPSIAA
MLBr_02378|M.leprae_Br4923 TNAGLVFAFTMASMVVSDLRVIGQVGTTIGLGLLFDTLIVRSFMMPSIAA
Mflv_3435|M.gilvum_PYR-GCK TAAGLVFALTMMSMSVSELTVIGQVGTTIGLGLLFDTLVIRAFMTPSIAA
Mvan_3189|M.vanbaalenii_PYR-1 TAAGLVFALTMMSMAVSELTVIGQVGTTIGLGLLFDTLVIRAFMTPSIAA
MUL_0757|M.ulcerans_Agy99 TAAGLVFAFTMMSFAVSELTVMAQVGTTIGMGLLFDTLIVRSFMTPSIAA
MAV_2510|M.avium_104 TSAGLVFAFTMMTMAVSELTVIGQVGTTIGLGLLFDTLIVRSLMTPSIAA
MAB_2301|M.abscessus_ATCC_1997 TSAGLVFAFTMAVMVVSDLRIIGQVGTTIALGLLFDTLIVRSFMTPAVAT
MSMEG_0382|M.smegmatis_MC2_155 TSAGLVFAGTMAAMVVSDLRIIGQIGTTIGLGLLFDTMIVRSFMTPSIAA
TH_3056|M.thermoresistible__bu TMAGLVFAATMASMIVSDLLMIGQVGTTIALGLLFDTMVVRAFMTPSVAA
* ****** ** : **:* ::.*:****.:******:::*::* *::*:
Rv0450c|M.tuberculosis_H37Rv LLGRWFWWPLRVRSRPARTPTVPSETQPAGRPLAMSSDRLG---------
Mb0458c|M.bovis_AF2122/97 LLGRWFWWPLRVRSRPARTPTVPSETQPAGRPLAMSSDRLG---------
MMAR_0771|M.marinum_M LLGRWFWWPMRVRTRPARTPSSPTADPEPDRALAMSGER-----------
MLBr_02378|M.leprae_Br4923 LLGRWFWWPQQGRTRPLLTVAAPVG-LPPDRSLVYSD-------------
Mflv_3435|M.gilvum_PYR-GCK LLGPWFWWPQRVRTRPVPAPWPRSGGLQSDPSEGVRA-------------
Mvan_3189|M.vanbaalenii_PYR-1 LLGPWFWWPQRVRTRPVPAPWPRPGGLQSDPSEGVKV-------------
MUL_0757|M.ulcerans_Agy99 LLGKWFWWPQVVRQRPAPQPWPTPAPTPPPATTSV---------------
MAV_2510|M.avium_104 LLGKWFWWPQRVRQRPVPSPWPKPAAQEREVLADA---------------
MAB_2301|M.abscessus_ATCC_1997 LLGRWFWWPLNVRTRPLPPPRTTVAADPTPPPVPVGPGHGDDPITTEFPR
MSMEG_0382|M.smegmatis_MC2_155 LLGRWFWWPQKVRPRPASALLEPYGPRPLVRALLEGPSGAASPGGPGGRL
TH_3056|M.thermoresistible__bu ILGRWFWWPQRVRTRPASAMLRPVGPRPLVRSLLLRD-------------
:** ***** * **
Rv0450c|M.tuberculosis_H37Rv -------------
Mb0458c|M.bovis_AF2122/97 -------------
MMAR_0771|M.marinum_M -------------
MLBr_02378|M.leprae_Br4923 -------------
Mflv_3435|M.gilvum_PYR-GCK -------------
Mvan_3189|M.vanbaalenii_PYR-1 -------------
MUL_0757|M.ulcerans_Agy99 -------------
MAV_2510|M.avium_104 -------------
MAB_2301|M.abscessus_ATCC_1997 PSV----------
MSMEG_0382|M.smegmatis_MC2_155 SDDDTPTGPMRTR
TH_3056|M.thermoresistible__bu -------------