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LWHSMPPELNTARLMVGAGAAPMLAAAMGWEAWAAALDAQAAEVSVRLNSLGEAWTGAGSDKAIAAATPM VTWLATASAQAKIRASKATAQAAAYTQAMAETPSLPEIAQNHVTTAALTATNFFGINTVPIAVNETDYFV RMWNQAAAAMDRYQAETIINTIFDKLEPMKPILASVGRFVTNGLDQAARIAPSVALPSKEAIGQTAAQVS GMTSSAQQLAQLVQQTTTLFSHTGGAGAAVSDAEQGTQVGLLGVSPLSNHPLAGGSGPSVGAGLIRADSM PGSAGLLARTSLMAQLVDKPTAAMAPTPASAAPSATAGTAPLGHMGHSAPAGSGSSRPRPATRTLVLPEL DETDPHGWDAGEDW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_5417 | - | - | 100% (365) | PPE family protein |
| M. marinum M | MMAR_5448 | - | e-114 | 59.25% (373) | PPE family protein |
| M. marinum M | MMAR_4346 | - | e-105 | 62.78% (317) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3903 | PPE68 | 1e-119 | 60.38% (371) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0768 | - | 2e-69 | 38.12% (425) | PPE protein |
| M. tuberculosis H37Rv | Rv3873 | PPE68 | 1e-119 | 60.38% (371) | PPE family protein |
| M. leprae Br4923 | MLBr_00051 | - | 2e-43 | 40.64% (283) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 3e-32 | 30.38% (372) | PPE family protein |
| M. avium 104 | MAV_4872 | - | 8e-36 | 31.08% (370) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0064 | - | 5e-80 | 42.29% (402) | PPE family protein |
| M. thermoresistible (build 8) | TH_4447 | - | 1e-85 | 43.99% (441) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1154 | - | 1e-32 | 40.19% (209) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0077 | - | 1e-74 | 38.85% (435) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3903|M.bovis_AF2122/97 ---------MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQ
Rv3873|M.tuberculosis_H37Rv ---------MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQ
MMAR_5417|M.marinum_M ---------MLWHSMPPELNTARLMVGAGAAPMLAAAMGWEAWAAALDAQ
Mflv_0768|M.gilvum_PYR-GCK MANIGIPVPPSWVAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
Mvan_0077|M.vanbaalenii_PYR-1 MATIGIPIPPIWGAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
TH_4447|M.thermoresistible__bu ---------MFWHAMPPEVNTSRLMAGAGTAPMLQAAAGWEAFAISLETQ
MSMEG_0064|M.smegmatis_MC2_155 ----------MWIALPPEINTARLMVGAGPAPMLQAAAGWEGLAVLLETQ
MLBr_00051|M.leprae_Br4923 --------------------MTWPMLWPASVPSECPPNYWHTPAPSAKCE
MAB_4783|M.abscessus_ATCC_1997 ------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTEYSSA
MAV_4872|M.avium_104 ------MTAPVWMAFAPEVHSTLLSSGPGPAGLLSAAASWTSLSETYASA
MUL_1154|M.ulcerans_Agy99 ------MTAPLWMASAPEAHSALLSAGPGPGSLLAAAQTWTELSAEYLAV
: ... .. * :
Mb3903|M.bovis_AF2122/97 AVELTARLNSLGE-AWTGGGSDKALAAATPMVVWLQTASTQAKTRAMQAT
Rv3873|M.tuberculosis_H37Rv AVELTARLNSLGE-AWTGGGSDKALAAATPMVVWLQTASTQAKTRAMQAT
MMAR_5417|M.marinum_M AAEVSVRLNSLGE-AWTGAGSDKAIAAATPMVTWLATASAQAKIRASKAT
Mflv_0768|M.gilvum_PYR-GCK ADELASSLASLSQ-NWQGMASERAVTAAMPMVLWLRMLSLQAHKRALQAS
Mvan_0077|M.vanbaalenii_PYR-1 ADELAASLATLSQ-MWQGTASERAVMATMPMVMWLRMLSLQAQKRAAQAS
TH_4447|M.thermoresistible__bu ADELAGSLAALAG-AWTGGASERAIAAITPMIVWLRTVSAQAHKRSAQAL
MSMEG_0064|M.smegmatis_MC2_155 AAELAAALTNLTS-VWTGAASERAVAATMPMITWLQTTAAQAQKRALQAS
MLBr_00051|M.leprae_Br4923 PEQAAVAP----------------IAAAKPMITWLQSAAEQTTT------
MAB_4783|M.abscessus_ATCC_1997 ANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVAAQTE
MAV_4872|M.avium_104 AAELSATLAAAQSDAWQGPSAERYVAAHAPYLAWLERASANSAAVAAQQE
MUL_1154|M.ulcerans_Agy99 AEELTAILTGVQAGAWDGPSAQCCIAAYLPYLSWLMQASADSAATAAAHQ
. : : * * : ** : :
Mb3903|M.bovis_AF2122/97 AQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYF
Rv3873|M.tuberculosis_H37Rv AQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYF
MMAR_5417|M.marinum_M AQAAAYTQAMAETPSLPEIAQNHVTTAALTATNFFGINTVPIAVNETDYF
Mflv_0768|M.gilvum_PYR-GCK AQASSWTVAATGTPQLPEIELNHVTNATLHATNFLGVNGIPIALNEADY-
Mvan_0077|M.vanbaalenii_PYR-1 AQATAWASAATSTPQLPEIETNHITNAVLNATNFLGVNTVPIAVNEADY-
TH_4447|M.thermoresistible__bu AQAAAYSTAMATTPPLAEIEQNHITRAVLHATNFLGINTVPIGINEMDYF
MSMEG_0064|M.smegmatis_MC2_155 AQASSYSLALATTPPLPEIEQNHITHGVLEATNFLGINTVPIALNEMDYF
MLBr_00051|M.leprae_Br4923 -QAEAHRQAMASTPGMAVITENHITQAILATINFFGINMAPIAFTEAGDF
MAB_4783|M.abscessus_ATCC_1997 TAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNEADY-
MAV_4872|M.avium_104 TAAAAYTAALAAMPTLPELAGNHATHAALVATNFFGVNTIPIAVNEADY-
MUL_1154|M.ulcerans_Agy99 AAATAYTGALAAMPTLGELAANHATHAVLVATNFFGLNTIPIALNEVDY-
* : * : * : : ** * . * : **:*:* **...* .
Mb3903|M.bovis_AF2122/97 IRMWNQAALAMEVYQAETAVNTLFEKLEPMASILDPGASQSTTNPIFGMP
Rv3873|M.tuberculosis_H37Rv IRMWNQAALAMEVYQAETAVNTLFEKLEPMASILDPGASQSTTNPIFGMP
MMAR_5417|M.marinum_M VRMWNQAAAAMDRYQAETIINTIFDKLEPMKPILAS-VGRFVTN---GLD
Mflv_0768|M.gilvum_PYR-GCK IRMWNQAAAVMTAYETETVLNTTFEPVAPPKPIAVPPGSEAAFAGAMSGA
Mvan_0077|M.vanbaalenii_PYR-1 IRMWNQAAAVMTGYETETILNSTFEPVAPPKPITVFGSTQAAMATAIGSA
TH_4447|M.thermoresistible__bu VRMWNQAAGAMDVYQAETAMNILFEPIMPMKPIVIPGVGEAAVAGALGKA
MSMEG_0064|M.smegmatis_MC2_155 VRMWNQAAGAMDVYHAETTVNLLFEPIMPMKPIVLPGVGETTAAAALAQT
MLBr_00051|M.leprae_Br4923 ICMRTQTALAMNSYQAETLLNTAFQKLEPMAAILNPSSYSPPSALTSQVN
MAB_4783|M.abscessus_ATCC_1997 IRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAARTAAQDA
MAV_4872|M.avium_104 ARMWVQAATTMSTYQAVAGTAVAAAPQTDPAPPIVN--STSSDGSDSDDS
MUL_1154|M.ulcerans_Agy99 VRMWIQAATTMSVYQAVAADALLAVPRTPPAPVIIKPGADAAAQFAS---
* *:* .* *.: : .
Mb3903|M.bovis_AF2122/97 SP------------------------------GSSTPVGQLPP--AATQT
Rv3873|M.tuberculosis_H37Rv SP------------------------------GSSTPVGQLPP--AATQT
MMAR_5417|M.marinum_M QA------------------------------ARIAPSVALPSKEAIGQT
Mflv_0768|M.gilvum_PYR-GCK VPGAGEAV---------------------MRNAIISKVSSTAKLDTANQI
Mvan_0077|M.vanbaalenii_PYR-1 APGIASAA---------------------ARNATFTKVSVVGKLDEVNQK
TH_4447|M.thermoresistible__bu AAMAPAAA---------------------ARDLVFAKVSAQATVESAALQ
MSMEG_0064|M.smegmatis_MC2_155 APRVAEGV---------------------MRNAVIEGVSAIATIESVGLA
MLBr_00051|M.leprae_Br4923 QFT----------------------------QMISGFSAALPSTQVLQQT
MAB_4783|M.abscessus_ATCC_1997 TKPPPIVP-DPNDPIEMLLKNS---QHFLGMYRALKGLITDPVGTIVRII
MAV_4872|M.avium_104 GDDGGIVDNDGGNPYQLSWWVNRFLEIFQTIGRDLEEFPENPSAALTQLL
MUL_1154|M.ulcerans_Agy99 --------------------------------AVVQAVAETP---IQRLL
Mb3903|M.bovis_AF2122/97 LG------------------------------------------------
Rv3873|M.tuberculosis_H37Rv LG------------------------------------------------
MMAR_5417|M.marinum_M AA------------------------------------------------
Mflv_0768|M.gilvum_PYR-GCK AG-----------RAEGTLRGVVDRAGSHAEKSQGLEQAPQ----QGMQM
Mvan_0077|M.vanbaalenii_PYR-1 AG-----------HAEGLLQQAADSGRSQAEQGQLLQQAPQ----QGMQM
TH_4447|M.thermoresistible__bu AGRAVAQGNMAAQRAEGTVQKTENLAHQSATRSE--PQQLQ----QGVQM
MSMEG_0064|M.smegmatis_MC2_155 AG-----------HAAAQANFAEQRGQGAAQKGENAGQEAGRESGKNMQQ
MLBr_00051|M.leprae_Br4923 VG------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 IDFSTNPAAAIVTWTPLFYVFAYAATFAVMGTPIYAAIMGP-----AAGI
MAV_4872|M.avium_104 RDIWLLIVDEIGHAIEAFQAFA--PQIAAFSLALPAGAAAG-----LAGL
MUL_1154|M.ulcerans_Agy99 LELATLVGAEFINVFELIVGIVVLSTYG-LKLPLLALLDFL-----TGHF
Mb3903|M.bovis_AF2122/97 ------QLG------------EMSGPMQQLTQPLQQVTSLFSQVGGTGGG
Rv3873|M.tuberculosis_H37Rv ------QLG------------EMSGPMQQLTQPLQQVTSLFSQVGGTGGG
MMAR_5417|M.marinum_M ------QVS------------GMTSSAQQLAQLVQQTTTLFSHTGGAGAA
Mflv_0768|M.gilvum_PYR-GCK GMQMASQLGSTLGQMPQQMMQGVTQPFQQLTQPLQQMSSLFGGM--MNGD
Mvan_0077|M.vanbaalenii_PYR-1 GMQMASQLGSTLGQLPQQMMQGVTQPFQQLTQPLQQMSSLFGQMGGLGGD
TH_4447|M.thermoresistible__bu GMQMGSQLGSTLAQLPQQAGQMISQPMQQLTAPLQQVSSVFGQMGGMGSG
MSMEG_0064|M.smegmatis_MC2_155 GMQMVMQMGSQAAQAPAQLASMFQSGVQTMTQPLQQATQMVSQFASMGGS
MLBr_00051|M.leprae_Br4923 ------------------QVAELARPMQQVKSLFTSIDSTGVYTSAQRGD
MAB_4783|M.abscessus_ATCC_1997 SIPLAITLAS-LSQMPEAPPVDAPAETVPARIDQPHAVAMGGAPAPTAST
MAV_4872|M.avium_104 SGLAAIQKAAPLPALPAAPPPQP--SSMPAVVAGPAMGAAAVAAPAPASA
MUL_1154|M.ulcerans_Agy99 SVALSLLWNYAMLWFGFVVPPALQIVFDPLLVVAAVIEWILGGGAALGSV
.
Mb3903|M.bovis_AF2122/97 NPADEEAAQMGLLGTSPLSNHPLAG---------------GSGPSAGAGL
Rv3873|M.tuberculosis_H37Rv NPADEEAAQMGLLGTSPLSNHPLAG---------------GSGPSAGAGL
MMAR_5417|M.marinum_M VSDAEQGTQVGLLGVSPLSNHPLAG---------------GSGPSVGAGL
Mflv_0768|M.gilvum_PYR-GCK K-----GAQIGMVGATPFSNHPAIG---------------GTGPATGSGL
Mvan_0077|M.vanbaalenii_PYR-1 R-----GAQIGMLGATPFSNHPAIG---------------GSGAATGAGL
TH_4447|M.thermoresistible__bu D-----SAQIGLIGASPFSNHPLAG---------------GSGPATGAGL
MSMEG_0064|M.smegmatis_MC2_155 ER----AMQVGLMGASPFSNHPMLG---------------GSGPSTGAGL
MLBr_00051|M.leprae_Br4923 TES---AHRIGLFGASTLSSHPLVG---------------ITGTTTDTRL
MAB_4783|M.abscessus_ATCC_1997 AAPTPTTTSPATPGSAPAPTPPPAGAEGLGYAVRGDGPGFGFGPTIGAST
MAV_4872|M.avium_104 GAPAPASATVTASGAAP---PPPSGIGGTAYPYLIGGPTIGSGTGMGSGA
MUL_1154|M.ulcerans_Agy99 GALDAN-----------------------------------LAAGLALAA
..
Mb3903|M.bovis_AF2122/97 LRAESLPGAGGSLTRTPLMSQLIE-----------------------KPV
Rv3873|M.tuberculosis_H37Rv LRAESLPGAGGSLTRTPLMSQLIE-----------------------KPV
MMAR_5417|M.marinum_M IRADSMPGSAGLLARTSLMAQLVD-----------------------KPT
Mflv_0768|M.gilvum_PYR-GCK VRAASLPGAGGSAPQTPLMSNLVGS--------------------GLQPT
Mvan_0077|M.vanbaalenii_PYR-1 VRAASLPGAGGTAARTPLMSNLVGS--------------------GLQPT
TH_4447|M.thermoresistible__bu VRAASLPGLGGTSPTTSLISNLLG---------------------HQNPT
MSMEG_0064|M.smegmatis_MC2_155 VRAMSLPGAGGTAPRTPLLSNLLG------------------------IS
MLBr_00051|M.leprae_Br4923 LCAESLPSASGSLAWTPLMTQFQL--------------------------
MAB_4783|M.abscessus_ATCC_1997 GATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRGYRHEYATMDDHT
MAV_4872|M.avium_104 QRKASEPDPAAAAAPAGASASERARARRRRRAAMKDR-YR-GYEFMDVEP
MUL_1154|M.ulcerans_Agy99 VAAAPVADAAVGSLGVLTSAAAVT--------------------------
.. . .
Mb3903|M.bovis_AF2122/97 APSVMPAAAAGSSATGGAAPVGAGA-------MGQGAQSG--GSTRPGLV
Rv3873|M.tuberculosis_H37Rv APSVMPAAAAGSSATGGAAPVGAGA-------MGQGAQSG--GSTRPGLV
MMAR_5417|M.marinum_M AAMAPTPASAAPSATAGTAPLGH---------MGHSAPAGS-GSSRPRPA
Mflv_0768|M.gilvum_PYR-GCK -SPVAVGAGAGPGAGVGLAPVGTGGGMGAGGPMGMFGQRGKSGGNKPGLN
Mvan_0077|M.vanbaalenii_PYR-1 VSAVAVGAGAGAGAGAGLAPVGAGSGMGGGGPMGMLGQRGKSGGNKPGLN
TH_4447|M.thermoresistible__bu AAPAPTGAVAG-GAGTGPAPIG-GGGMG--APMAAMGQNQKSGGSKSGLK
MSMEG_0064|M.smegmatis_MC2_155 GEMKAAPAGAGSAAAGGLAPVGAGAGGGAGAPVAHAGQNSKSGGKKDGLV
MLBr_00051|M.leprae_Br4923 ---IDKSIAPEPRQRVMLPPWAAGS----------PGHNAQDGGTT----
MAB_4783|M.abscessus_ATCC_1997 PTGPQ-DPVTAVASGTGAGRLGFAGVHTATTAVEATGLSTLDGDAENR--
MAV_4872|M.avium_104 DAGPEPETDSVTASDRGAGPLGFAGT-APSAPAQATGLATLAGDEFGTGP
MUL_1154|M.ulcerans_Agy99 -------AAAAAAPGQGVGLVGFAATMPNPTTLPAGGLVTVGGADPCAGA
. . . *
Mb3903|M.bovis_AF2122/97 APAPLAQEREEDDEDDWDEEDDW
Rv3873|M.tuberculosis_H37Rv APAPLAQEREEDDEDDWDEEDDW
MMAR_5417|M.marinum_M TRTLVLPELDETDPHGWDAGEDW
Mflv_0768|M.gilvum_PYR-GCK APAPLDHDLGEDEDEEW------
Mvan_0077|M.vanbaalenii_PYR-1 APAPLEHDLSEDDDDDW------
TH_4447|M.thermoresistible__bu APAPLVQDLSEDEGDDW------
MSMEG_0064|M.smegmatis_MC2_155 APTPLTYDLSEDEDDEW------
MLBr_00051|M.leprae_Br4923 -----------------------
MAB_4783|M.abscessus_ATCC_1997 TIPMLPGTWDVTDDDR-------
MAV_4872|M.avium_104 SMPMVPGNWTGE-----------
MUL_1154|M.ulcerans_Agy99 RVPMLPASWVALG----------