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LWHAMPPELNTARLMAGAGPTSMLAVATGWKDWAAALDAQAIEVSARLKSAGEVCSGESGDRAIAAAVPM VSWLATASARAKARATQALAQAAAHADALAATPPLPEIAMNHITAAVVTATNFLGMSTALIALSETDYFT RMWNQAAAAMDAYQAQTAVNTRFGEPDSIKTNLGVWGLANGLDRVATIARNVALPAKEAIRQTLTQTSGM GCSIPQPAQVTSLFGHPGGTGAGLDQGEGVQIGLLGASPLSHHPLAGGSGPSAGAGLMRADSLPGAGGLS ARTPLLAGLLDKPTVAMGPAAVSAESAATRALPDVTPATTRRRCLPADK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4346 | - | - | 100% (330) | PPE family protein |
| M. marinum M | MMAR_5417 | - | e-105 | 62.78% (317) | PPE family protein |
| M. marinum M | MMAR_5448 | - | 2e-85 | 53.40% (324) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3903 | PPE68 | 6e-89 | 55.96% (327) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0768 | - | 4e-41 | 33.51% (367) | PPE protein |
| M. tuberculosis H37Rv | Rv3873 | PPE68 | 6e-89 | 55.96% (327) | PPE family protein |
| M. leprae Br4923 | MLBr_00051 | - | 1e-29 | 36.33% (245) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 2e-28 | 44.17% (163) | PPE-family protein |
| M. avium 104 | MAV_0118 | - | 3e-31 | 33.83% (266) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0064 | - | 1e-64 | 41.09% (387) | PPE family protein |
| M. thermoresistible (build 8) | TH_4447 | - | 5e-68 | 40.82% (392) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1154 | - | 1e-28 | 47.17% (159) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0077 | - | 2e-48 | 35.22% (389) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3903|M.bovis_AF2122/97 ---------MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQ
Rv3873|M.tuberculosis_H37Rv ---------MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQ
MMAR_4346|M.marinum_M ---------MLWHAMPPELNTARLMAGAGPTSMLAVATGWKDWAAALDAQ
Mflv_0768|M.gilvum_PYR-GCK MANIGIPVPPSWVAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
Mvan_0077|M.vanbaalenii_PYR-1 MATIGIPIPPIWGAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
TH_4447|M.thermoresistible__bu ---------MFWHAMPPEVNTSRLMAGAGTAPMLQAAAGWEAFAISLETQ
MSMEG_0064|M.smegmatis_MC2_155 ----------MWIALPPEINTARLMVGAGPAPMLQAAAGWEGLAVLLETQ
MLBr_00051|M.leprae_Br4923 --------------------MTWPMLWPASVPSECPPNYWHTPAPSAKCE
MAB_0669|M.abscessus_ATCC_1997 ------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNNYANT
MUL_1154|M.ulcerans_Agy99 ------MTAPLWMASAPEAHSALLSAGPGPGSLLAAAQTWTELSAEYLAV
MAV_0118|M.avium_104 ------MTAPVWMALPPEVHSTLLSSGPGPGPLLAAAATWTGLSTQYDSA
: ... . . * .
Mb3903|M.bovis_AF2122/97 AVELTARLN-SLGEAWTGGGSDKALAAATPMVVWLQTASTQAKTRAMQAT
Rv3873|M.tuberculosis_H37Rv AVELTARLN-SLGEAWTGGGSDKALAAATPMVVWLQTASTQAKTRAMQAT
MMAR_4346|M.marinum_M AIEVSARLK-SAGEVCSGESGDRAIAAAVPMVSWLATASARAKARATQAL
Mflv_0768|M.gilvum_PYR-GCK ADELASSLA-SLSQNWQGMASERAVTAAMPMVLWLRMLSLQAHKRALQAS
Mvan_0077|M.vanbaalenii_PYR-1 ADELAASLA-TLSQMWQGTASERAVMATMPMVMWLRMLSLQAQKRAAQAS
TH_4447|M.thermoresistible__bu ADELAGSLA-ALAGAWTGGASERAIAAITPMIVWLRTVSAQAHKRSAQAL
MSMEG_0064|M.smegmatis_MC2_155 AAELAAALT-NLTSVWTGAASERAVAATMPMITWLQTTAAQAQKRALQAS
MLBr_00051|M.leprae_Br4923 PEQAAVAP----------------IAAAKPMITWLQSAAEQTTT------
MAB_0669|M.abscessus_ATCC_1997 AVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIAAQHE
MUL_1154|M.ulcerans_Agy99 AEELTAILTGVQAGAWDGPSAQCCIAAYLPYLSWLMQASADSAATAAAHQ
MAV_0118|M.avium_104 ATELTAVLTGSMP-VWDGPTADRYVAAHMPYLAWLQLAGALSAEAAAQHQ
. : : : * * : ** . :
Mb3903|M.bovis_AF2122/97 AQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYF
Rv3873|M.tuberculosis_H37Rv AQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYF
MMAR_4346|M.marinum_M AQAAAHADALAATPPLPEIAMNHITAAVVTATNFLGMSTALIALSETDYF
Mflv_0768|M.gilvum_PYR-GCK AQASSWTVAATGTPQLPEIELNHVTNATLHATNFLGVNGIPIALNEADY-
Mvan_0077|M.vanbaalenii_PYR-1 AQATAWASAATSTPQLPEIETNHITNAVLNATNFLGVNTVPIAVNEADY-
TH_4447|M.thermoresistible__bu AQAAAYSTAMATTPPLAEIEQNHITRAVLHATNFLGINTVPIGINEMDYF
MSMEG_0064|M.smegmatis_MC2_155 AQASSYSLALATTPPLPEIEQNHITHGVLEATNFLGINTVPIALNEMDYF
MLBr_00051|M.leprae_Br4923 -QAEAHRQAMASTPGMAVITENHITQAILATINFFGINMAPIAFTEAGDF
MAB_0669|M.abscessus_ATCC_1997 TTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIALNEADY-
MUL_1154|M.ulcerans_Agy99 AAATAYTGALAAMPTLGELAANHATHAVLVATNFFGLNTIPIALNEVDY-
MAV_0118|M.avium_104 GVATAYTAALAAMPTLPELAANHATHAALVATNFFGVNTIPIAVNEADY-
* : * : * : : ** * . : **:*:. *...* .
Mb3903|M.bovis_AF2122/97 IRMWNQAALAMEVYQAETAVNTLFEKLEPMA-------------------
Rv3873|M.tuberculosis_H37Rv IRMWNQAALAMEVYQAETAVNTLFEKLEPMA-------------------
MMAR_4346|M.marinum_M TRMWNQAAAAMDAYQAQTAVNTRFGEPDSIK-------------------
Mflv_0768|M.gilvum_PYR-GCK IRMWNQAAAVMTAYETETVLNTTFEPVAPPK-------------------
Mvan_0077|M.vanbaalenii_PYR-1 IRMWNQAAAVMTGYETETILNSTFEPVAPPK-------------------
TH_4447|M.thermoresistible__bu VRMWNQAAGAMDVYQAETAMNILFEPIMPMK-------------------
MSMEG_0064|M.smegmatis_MC2_155 VRMWNQAAGAMDVYHAETTVNLLFEPIMPMK-------------------
MLBr_00051|M.leprae_Br4923 ICMRTQTALAMNSYQAETLLNTAFQKLEPMA-------------------
MAB_0669|M.abscessus_ATCC_1997 VRMWVQAAATMSAYQATTEAMTSAIPPTQQP-------------------
MUL_1154|M.ulcerans_Agy99 VRMWIQAATTMSVYQAVAADALLAVPRTPPA-------------------
MAV_0118|M.avium_104 ARMWTQAATTMTTYQATTEAVQMTSVAGSGTGGKAGSGSGSGTGAGTGTG
* *:* .* *.: :
Mb3903|M.bovis_AF2122/97 ----------------------------------------------SILD
Rv3873|M.tuberculosis_H37Rv ----------------------------------------------SILD
MMAR_4346|M.marinum_M ----------------------------------------------TNLG
Mflv_0768|M.gilvum_PYR-GCK ----------------------------------------------PIAV
Mvan_0077|M.vanbaalenii_PYR-1 ----------------------------------------------PITV
TH_4447|M.thermoresistible__bu ----------------------------------------------PIVI
MSMEG_0064|M.smegmatis_MC2_155 ----------------------------------------------PIVL
MLBr_00051|M.leprae_Br4923 ----------------------------------------------AILN
MAB_0669|M.abscessus_ATCC_1997 ---------------------------------------------PAILS
MUL_1154|M.ulcerans_Agy99 ---------------------------------------------PVIIK
MAV_0118|M.avium_104 TGTGTGTGTGTGTGTGAGSGTGGGTGAGGGGGTGSFQLPTPEEIWEMLFG
Mb3903|M.bovis_AF2122/97 PGA-----------------------------------------------
Rv3873|M.tuberculosis_H37Rv PGA-----------------------------------------------
MMAR_4346|M.marinum_M VWG-----------------------------------------------
Mflv_0768|M.gilvum_PYR-GCK PPG-----------------------------------------------
Mvan_0077|M.vanbaalenii_PYR-1 FGS-----------------------------------------------
TH_4447|M.thermoresistible__bu PGV-----------------------------------------------
MSMEG_0064|M.smegmatis_MC2_155 PGV-----------------------------------------------
MLBr_00051|M.leprae_Br4923 PSS-----------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 PGGEARSDQSDVPGSPDQIMKMLQGFQQ----------------------
MUL_1154|M.ulcerans_Agy99 PGADAAAQ------------------------------------------
MAV_0118|M.avium_104 PDGEQIPGQGQPNWSPSEYLQNLGNFFNGNAQAVAWLQQNLSGLLNPSQF
Mb3903|M.bovis_AF2122/97 -------SQSTTNPIFGMPSPGSSTPVG----------------------
Rv3873|M.tuberculosis_H37Rv -------SQSTTNPIFGMPSPGSSTPVG----------------------
MMAR_4346|M.marinum_M -------LANGLDRVATIAR-NVALPA-----------------------
Mflv_0768|M.gilvum_PYR-GCK -------SEAAFAGAMSGAVPGAGEAVMRNAIISKVSSTAKLDTANQIAG
Mvan_0077|M.vanbaalenii_PYR-1 -------TQAAMATAIGSAAPGIASAAARNATFTKVSVVGKLDEVNQKAG
TH_4447|M.thermoresistible__bu -------GEAAVAGALGKAAAMAPAAAARDLVFAKVSAQATVESAALQAG
MSMEG_0064|M.smegmatis_MC2_155 -------GETTAAAALAQTAPRVAEGVMRNAVIEGVSAIATIESVGLAAG
MLBr_00051|M.leprae_Br4923 -------YSPPSALTSQVNQFTQMISGFS---------------------
MAB_0669|M.abscessus_ATCC_1997 -----WFEKMGFNPATSAVLAVIMLFLYDLLWYPYYASYLLPFLIPALSG
MUL_1154|M.ulcerans_Agy99 ------FASAVVQAVAETPIQRLLLELATLVGAEFINVFELIVGIVVLST
MAV_0118|M.avium_104 PALINYFIAWQTYRIINWTIRTLRFILQELPLLLQVGLSLSITSLGGLAG
Mb3903|M.bovis_AF2122/97 --------------------------------------------------
Rv3873|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4346|M.marinum_M --------------------------------------------------
Mflv_0768|M.gilvum_PYR-GCK -----------RAEGTLRGVVDRAGSHAEKSQGLEQAPQ----QGMQMGM
Mvan_0077|M.vanbaalenii_PYR-1 -----------HAEGLLQQAADSGRSQAEQGQLLQQAPQ----QGMQMGM
TH_4447|M.thermoresistible__bu RAVAQGNMAAQRAEGTVQKTENLAHQSATRSE--PQQLQ----QGVQMGM
MSMEG_0064|M.smegmatis_MC2_155 -----------HAAAQANFAEQRGQGAAQKGENAGQEAGRESGKNMQQGM
MLBr_00051|M.leprae_Br4923 --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 --------------LSGLAALMHLRPAAPGPVPAAALSPGDRPIRRPTQH
MUL_1154|M.ulcerans_Agy99 --------------YGLKLPLLALLDFLTG-------------------H
MAV_0118|M.avium_104 --------------LAGLAGLAGLAAPASAPAPAAMPQPAGMGAQPPVVS
Mb3903|M.bovis_AF2122/97 QLPPAATQTLGQL-----GEMSGPMQQLTQPLQQVTSLFSQVGGTGGGNP
Rv3873|M.tuberculosis_H37Rv QLPPAATQTLGQL-----GEMSGPMQQLTQPLQQVTSLFSQVGGTGGGNP
MMAR_4346|M.marinum_M --KEAIRQTLTQT-----SGMGCSIPQP----AQVTSLFGHPGGTGAG-L
Mflv_0768|M.gilvum_PYR-GCK QMASQLGSTLGQMPQQMMQGVTQPFQQLTQPLQQMSSLFGGM--MNGDK-
Mvan_0077|M.vanbaalenii_PYR-1 QMASQLGSTLGQLPQQMMQGVTQPFQQLTQPLQQMSSLFGQMGGLGGDR-
TH_4447|M.thermoresistible__bu QMGSQLGSTLAQLPQQAGQMISQPMQQLTAPLQQVSSVFGQMGGMGSGD-
MSMEG_0064|M.smegmatis_MC2_155 QMVMQMGSQAAQAPAQLASMFQSGVQTMTQPLQQATQMVSQFASMGGSER
MLBr_00051|M.leprae_Br4923 --AALPSTQVLQQTVGQVAELARPMQQVKSLFTSIDSTGVYTSAQRGDTE
MAB_0669|M.abscessus_ATCC_1997 VEPNLAALPLPTSSVVPSGGSSVPVSTPTAPAHTVSSVPAPSAAISYAIP
MUL_1154|M.ulcerans_Agy99 FS---VALSLLWNYAMLWFGFVVPP--------ALQIVFDPLLVVAAVIE
MAV_0118|M.avium_104 AAPAMAPMAPTSPVAPATSAVSTPAPVASAIAPPATPPVPPAPVTGAEGF
Mb3903|M.bovis_AF2122/97 ADEE-AAQMGLLGTSPLS---NHPLAGGSGPSAGAGLLRAESLPGAGGSL
Rv3873|M.tuberculosis_H37Rv ADEE-AAQMGLLGTSPLS---NHPLAGGSGPSAGAGLLRAESLPGAGGSL
MMAR_4346|M.marinum_M DQGE-GVQIGLLGASPLS---HHPLAGGSGPSAGAGLMRADSLPGAGGLS
Mflv_0768|M.gilvum_PYR-GCK -----GAQIGMVGATPFS---NHPAIGGTGPATGSGLVRAASLPGAGGSA
Mvan_0077|M.vanbaalenii_PYR-1 -----GAQIGMLGATPFS---NHPAIGGSGAATGAGLVRAASLPGAGGTA
TH_4447|M.thermoresistible__bu -----SAQIGLIGASPFS---NHPLAGGSGPATGAGLVRAASLPGLGGTS
MSMEG_0064|M.smegmatis_MC2_155 -----AMQVGLMGASPFS---NHPMLGGSGPSTGAGLVRAMSLPGAGGTA
MLBr_00051|M.leprae_Br4923 S----AHRIGLFGASTLS---SHPLVGITGTTTDTRLLCAESLPSASGSL
MAB_0669|M.abscessus_ATCC_1997 GLVPPGVSFGPKSTEKS---SESAVDTVAAVAAARGAVAAQARRRLRGKN
MUL_1154|M.ulcerans_Agy99 WILGGGAALGSVGALDA---NLAAGLALAAVAAAP--VADAAVGSLG---
MAV_0118|M.avium_104 GYMVGSFGLGMDSKAQTRARSALAAGRPAASSAGAAAVEQEQGRTRRRPR
. .* . . :. :: :
Mb3903|M.bovis_AF2122/97 TRTPLMSQLIE---KPVAPSVMPAAAAGSSATGGAAPVGAGAMGQG----
Rv3873|M.tuberculosis_H37Rv TRTPLMSQLIE---KPVAPSVMPAAAAGSSATGGAAPVGAGAMGQG----
MMAR_4346|M.marinum_M ARTPLLAGLLD---KPTV-AMGPAAVSAESAATRALPD------------
Mflv_0768|M.gilvum_PYR-GCK PQTPLMSNLVGSGLQPT-SPVAVGAGAGPGAGVGLAPVGTGGGMGAGGPM
Mvan_0077|M.vanbaalenii_PYR-1 ARTPLMSNLVGSGLQPTVSAVAVGAGAGAGAGAGLAPVGAGSGMGGGGPM
TH_4447|M.thermoresistible__bu PTTSLISNLLG-HQNPTAAPAPTGAVAG-GAGTGPAPIG-GGGMG--APM
MSMEG_0064|M.smegmatis_MC2_155 PRTPLLSNLLG----ISGEMKAAPAGAGSAAAGGLAPVGAGAGGGAGAPV
MLBr_00051|M.leprae_Br4923 AWTPLMTQFQLIDKSIAPEPRQRVMLPPWAAGS-----------------
MAB_0669|M.abscessus_ATCC_1997 KAEAGGRRHEYLEETAGMGATATADVPAYAATGRGTGPLGFAGTAPAAAS
MUL_1154|M.ulcerans_Agy99 ----------------VLTSAAAVTAAAAAAPGQGVGLVGFAATMPNPTT
MAV_0118|M.avium_104 SVIDPGYRYEFIEGDDEVVAVASAAQDRYRPSDSGGSIQGFAGTLPKSG-
.
Mb3903|M.bovis_AF2122/97 -----AQSGGSTRPGLVAPAPLAQEREEDDEDDWDEEDDW
Rv3873|M.tuberculosis_H37Rv -----AQSGGSTRPGLVAPAPLAQEREEDDEDDWDEEDDW
MMAR_4346|M.marinum_M ----------------VTPATTRRRCLPADK---------
Mflv_0768|M.gilvum_PYR-GCK GMFGQRGKSGGNKPGLNAPAPLDHDLGEDEDEEW------
Mvan_0077|M.vanbaalenii_PYR-1 GMLGQRGKSGGNKPGLNAPAPLEHDLSEDDDDDW------
TH_4447|M.thermoresistible__bu AAMGQNQKSGGSKSGLKAPAPLVQDLSEDEGDDW------
MSMEG_0064|M.smegmatis_MC2_155 AHAGQNSKSGGKKDGLVAPTPLTYDLSEDEDDEW------
MLBr_00051|M.leprae_Br4923 ------------------PGHNAQDGGTT-----------
MAB_0669|M.abscessus_ATCC_1997 THVAATVRLSSDE--ARQVIPMLPSTWDADGGDQN-----
MUL_1154|M.ulcerans_Agy99 LPAGGLVTVGGADPCAGARVPMLPASWVALG---------
MAV_0118|M.avium_104 VRASGLNTLAGNESGDGARIPMLPESWDGP----------