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TAPVWMAFAPEVHSTLLSSGPGPAGLLSAAASWTSLSETYASAAAELSATLAAAQSDAWQGPSAERYVAA HAPYLAWLERASANSAAVAAQQETAAAAYTAALAAMPTLPELAGNHATHAALVATNFFGVNTIPIAVNEA DYARMWVQAATTMSTYQAVAGTAVAAAPQTDPAPPIVNSTSSDGSDSDDSGDDGGIVDNDGGNPYQLSWW VNRFLEIFQTIGRDLEEFPENPSAALTQLLRDIWLLIVDEIGHAIEAFQAFAPQIAAFSLALPAGAAAGL AGLSGLAAIQKAAPLPALPAAPPPQPSSMPAVVAGPAMGAAAVAAPAPASAGAPAPASATVTASGAAPPP PSGIGGTAYPYLIGGPTIGSGTGMGSGAQRKASEPDPAAAAAPAGASASERARARRRRRAAMKDRYRGYE FMDVEPDAGPEPETDSVTASDRGAGPLGFAGTAPSAPAQATGLATLAGDEFGTGPSMPMVPGNWTGE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4872 | - | - | 100% (488) | PPE family protein |
| M. avium 104 | MAV_4349 | - | e-122 | 48.48% (528) | PPE family protein |
| M. avium 104 | MAV_4879 | - | e-120 | 50.19% (540) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0288 | PPE3 | 1e-124 | 51.89% (530) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-102 | 43.68% (522) | PPE protein |
| M. tuberculosis H37Rv | Rv0280 | PPE3 | 1e-124 | 51.89% (528) | PPE family protein |
| M. leprae Br4923 | MLBr_00539 | PPE | 1e-87 | 40.78% (537) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 1e-103 | 45.82% (502) | PPE family protein |
| M. marinum M | MMAR_0538 | - | 1e-119 | 49.91% (529) | PPE family protein, PPE3 |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 4e-98 | 42.88% (520) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 2e-73 | 49.38% (322) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1202 | - | 1e-117 | 49.52% (525) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-100 | 43.16% (512) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0288|M.bovis_AF2122/97 ------------MTLWMASPPEVHSALLSSGPGPGSVLSAAGVWSSLSAE
Rv0280|M.tuberculosis_H37Rv ------------MTLWMASPPEVHSALLSSGPGPGSVLSAAGVWSSLSAE
MMAR_0538|M.marinum_M ----------MVAPVWFASPPEVHSALLSSGPGPASLLSGAAAWAGLSTE
MUL_1202|M.ulcerans_Agy99 --------------MWFTSPPEVHSALLSSGPGPASLLSGAAAWAGLSTE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
MAV_4872|M.avium_104 ----------MTAPVWMAFAPEVHSTLLSSGPGPAGLLSAAASWTSLSET
MLBr_00539|M.leprae_Br4923 ----------MTNP-WMAFPPEVQSAMLNFGAGVGPMLNSASYNLWLSAE
*:: .***:*::*. *.* . :* .. *.
Mb0288|M.bovis_AF2122/97 YAAVADELIGLLGAVQTGAWQGPSAAAYVAAHAPYLAWLMRASETSAEAA
Rv0280|M.tuberculosis_H37Rv YAAVADELIGLLGAVQTGAWQGPSAAAYVAAHAPYLAWLMRASETSAEAA
MMAR_0538|M.marinum_M YASVADELMGVLAAVQGGAWEGLSAELYVAAHVPYLMWLMRASATSAQAA
MUL_1202|M.ulcerans_Agy99 YASVADELMGVLAAVQGGAWEGLSAELYVAAHVPYLMWLMRASATSAQAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
MAV_4872|M.avium_104 YASAAAELSATLAAAQSDAWQGPSAERYVAAHAPYLAWLERASANSAAVA
MLBr_00539|M.leprae_Br4923 YRWVASEVEALLREVRSGGWQGQAVEMFVGSCMPFLAWLMKAAADYMDVA
* .* *: . * .: ..*.* : :*.: *:* ** : : *
Mb0288|M.bovis_AF2122/97 ARHETVAAAYTTAVAAMPTLVELAANHTLHGVLVATNFFGINTIPIALNE
Rv0280|M.tuberculosis_H37Rv ARHETVAAAYTTAVAAMPTLVELAANHTLHGVLVATNFFGINTIPIALNE
MMAR_0538|M.marinum_M AQHEAAAAAYTTALAAMPTMPELAANHVIHGVLMATNFFGINTIPIAANE
MUL_1202|M.ulcerans_Agy99 AQHEAAAAAYTTALAAMPTMPELAANHVIHGVLMATNFFGINTIPIAANE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
MAV_4872|M.avium_104 AQQETAAAAYTAALAAMPTLPELAGNHATHAALVATNFFGVNTIPIAVNE
MLBr_00539|M.leprae_Br4923 TQQEVVAAAYAAAVEAMPTQFELAANRVVRGVLMATNFFGVNTIPIALNE
:: ..*.**::*: .*** **: *:. :..*:.***:*:***** .*
Mb0288|M.bovis_AF2122/97 ADYARMWTQAASTMATYQAVAEAAVASAPQTTPAPPILAAEAADDDHDHD
Rv0280|M.tuberculosis_H37Rv ADYARMWTQAASTMATYQAVAEAAVASAPQTTPAPPILAAEAADDDHDHD
MMAR_0538|M.marinum_M ADYVRMWIQAATTMSTYQAVSAAAVASTPPSTPAPRILAAPAAA--HDHD
MUL_1202|M.ulcerans_Agy99 ADYVRMWIQAATTMSTYQAVSAAAVASTPPSTPAPRILAAPAAA--HDHD
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGE------
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGE------
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGE------
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSE------
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD----------
MAV_4872|M.avium_104 ADYARMWVQAATTMSTYQAVAGTAVAAAPQTDPAPPIVNS----------
MLBr_00539|M.leprae_Br4923 EEYVQMWVRAATTMATYSAISQSALAATPQATPPPLILKSNVLVDDVEKD
:*.:** :**::*:**.: : *: ::* : *.* ::
Mb0288|M.bovis_AF2122/97 -----HDHGGEPTPLDYLVAEILRIISGGRLIWDPAEGTMNGIPFEDYTD
Rv0280|M.tuberculosis_H37Rv -----HDHGGEPTPLDYLVAEILRIISGGRLIWDPAEGTMNGIPFEDYTD
MMAR_0538|M.marinum_M -----HDHGGDPTPIDYFVAEVLRIISGGRIIWDPAEGTVNGIPYDDYVN
MUL_1202|M.ulcerans_Agy99 -----HDHGGDPTPIDYFVAEVLRIISGGRIIWDPAEGTVNGIPYDDYVN
Mflv_0325|M.gilvum_PYR-GCK -------AGRAAADMSAFAAQPMAAQAGA--AFDVSNIIADIIRLYGEVL
Mvan_0415|M.vanbaalenii_PYR-1 -------AGRAAADVTAFAAQAQAAEAGS--ALDLSNIIADLIRAYGELL
MSMEG_0619|M.smegmatis_MC2_155 -------AGSASASVQQMSAQATAAESGS--SLDLSSIISDLLNQYLQGV
TH_3569|M.thermoresistible__bu -------AADAMATTQQIGSQATAADSGT--ALNLSDLIANLLQYYQDYL
MAB_0809c|M.abscessus_ATCC_199 ---------------HDHGHDDHDHEHGH--DDDHG---------HGDLD
MAV_4872|M.avium_104 -------------TSSDGSDSDDSGDDGG--IVDND-----------GGN
MLBr_00539|M.leprae_Br4923 SRHDGHSHGGHASAMDRVFADILRNVSGGRLVWDPLNGTLNGLDYDDYVY
. * :
Mb0288|M.bovis_AF2122/97 AAQPIWWVVRAIEFSKDFETFVQELFVNPVEAFQFYFELLLFDYPTHIVQ
Rv0280|M.tuberculosis_H37Rv AAQPIWWVVRAIEFSKDFETFVQELFVNPVEAFQFYFELLLFDYPTHIVQ
MMAR_0538|M.marinum_M AAQPIWWLVRALEFGQDFQTFIKELFTNPIGAIEFMVELVLFDWPTHIAQ
MUL_1202|M.ulcerans_Agy99 AAQPIWWLVRALEFGQDFQTFIKELFTNPIGAIEFMVELVLFDWPTHIAQ
Mflv_0325|M.gilvum_PYR-GCK RFLFEPIFNFLRDPIGNTFALITDFLTNPVQALITWG-PFLLAVVYQAVS
Mvan_0415|M.vanbaalenii_PYR-1 RFLFEPIFDFLRDPLGNTIKLITDFLTNPAQALITWG-PFLAAVAYQAVS
MSMEG_0619|M.smegmatis_MC2_155 PGGQ-AILDFLKDPLGNLGRLLTDFMTNPAGALATWW-PFLFGVAYQVFF
TH_3569|M.thermoresistible__bu DQLFGPIVDFLRDPIGNLFQLIDDFLTNPAGALVTWW-PLLFAVAYQVFT
MAB_0809c|M.abscessus_ATCC_199 PTDPEWWVHVAGEMVEHFELLLNNLLTDPAALLTNLP-MVLADVAFHAAQ
MAV_4872|M.avium_104 PYQLSWWVNRFLEIFQTIGRDLEEFPENPSAALTQLLRDIWLLIVDEIGH
MLBr_00539|M.leprae_Br4923 PGQPIWWLARGLEFFQDGEQFWELLFINPTAAFQFLLYIVVLDLPTHIVQ
. : : :* : . .
Mb0288|M.bovis_AF2122/97 IVEALSQSPQLLAVALGSVISNLGAVTGFAGLSGLAGMQPAAIPALAPVA
Rv0280|M.tuberculosis_H37Rv IVEALSQSPQLLAVALGSVISNLGAVTGFAGLSGLAGMQPAAIPALAPVA
MMAR_0538|M.marinum_M IIQALAQSPQLLAVALGGVVANLGAISGLAGLSGLAGLHSAALPA-AIAP
MUL_1202|M.ulcerans_Agy99 IIQALAQSPQLLAVALGGVVANLGAISGLAGLSGLAGLHSAALPA-AIAP
Mflv_0325|M.gilvum_PYR-GCK WVGASILYPSLFLLPL--LATTLAIV----AGVGQHLLSLLNTP-PAEEA
Mvan_0415|M.vanbaalenii_PYR-1 WVGASILYPSLLLLPL--VATTLAIV----LGVGAYLLENLPAP-AEDAP
MSMEG_0619|M.smegmatis_MC2_155 NLVGWPTWGMIFASPF--LIPALAAL----GITGLVLLIDHVLNNPVDVP
TH_3569|M.thermoresistible__bu NLVGWPTWAMILASPV--LIPLAITL----GVAGLVMIADQAQP-----P
MAB_0809c|M.abscessus_ATCC_199 LASTIGQFAPALIQPA--LALAIANLGWAAGFAGLAGIQPSPEILAVEPG
MAV_4872|M.avium_104 AIEAFQAFAPQIAAFS--LALPAGAAAGLAGLSGLAAIQKAAPLPALPAA
MLBr_00539|M.leprae_Br4923 LGTWLAEYPQLLLVALGGTIANLGAVT---GLAGLSSGLSAGPSAAIPTV
: *
Mb0288|M.bovis_AF2122/97 AAPPTLPAVAMAPTMAAPGAAVASAAAPASAPAASTVASATPAPPPAPGA
Rv0280|M.tuberculosis_H37Rv AAPSTLPAVAMAPTMAAPGAAVASAAAPASAPAASTVASATPAPPPAPGA
MMAR_0538|M.marinum_M IAPPMPPGVALAPTVATSVAAPTPPSAPPSA--TSTVANAAPPPPPAPAA
MUL_1202|M.ulcerans_Agy99 IAPPMPPGVALAPTVAASVAAPTPPSAPPSA--ASTVANAAPPPPPAPAA
Mflv_0325|M.gilvum_PYR-GCK AEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAP
Mvan_0415|M.vanbaalenii_PYR-1 AEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAP
MSMEG_0619|M.smegmatis_MC2_155 AEDEAPQEVAAAPRTDQPLAVGISPAGVPGSAATAAAPAPAPAGTTVAAP
TH_3569|M.thermoresistible__bu AEEAAPEEDVAAP-------------------VRAEPQNPLPLTXXX---
MAB_0809c|M.abscessus_ATCC_199 SVEDAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSPPPV
MAV_4872|M.avium_104 PPPQPSSMPAVVAGPAMGAAAVAAPAPASAGAPAPASATVTASGAAPPPP
MLBr_00539|M.leprae_Br4923 VPESAPIATVPAMLAGAGVAPAVVAPGASPSSAAPPASAASAAAAAPAPP
.
Mb0288|M.bovis_AF2122/97 AGFGYPYAIAP-PGIGFGSGMSAS--ASAQRKAPQPDSAAAAAAAAAVRD
Rv0280|M.tuberculosis_H37Rv AGFGYPYAIAP-PGIGFGSGMSAS--ASAQRKAPQPDSAAAAAAAAAVRD
MMAR_0538|M.marinum_M AGFGFPFVVGGGPGIGYGEGMSASAAASARRKAPEPD-SAALAAAAAARE
MUL_1202|M.ulcerans_Agy99 AGFGFPFVVGGGPGIGYGEGMSASAAASARRKAPEPD-SAALAAAAAVRE
Mflv_0325|M.gilvum_PYR-GCK AAAAATFVPYVVAGRDPYEGFSPTVRDSTGAKAPAGT-IPAAASGIAASA
Mvan_0415|M.vanbaalenii_PYR-1 AAATASFVPYAVAGRDPGTGFSPTVRDSTSAKAPASG-IPAAASGVAASA
MSMEG_0619|M.smegmatis_MC2_155 APAAATFVPYAVANRDPGEGFTPTLGNKSQVAAPASG-VPAAASGVAASL
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 GDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARS-SAREQAAAAETA
MAV_4872|M.avium_104 SGIGGTAYPYLIGGPTIGSGTGMGSGAQRKASEPDPA-AAAAPAGASASE
MLBr_00539|M.leprae_Br4923 GTGFGGFSPYLVDGRGPGVGFGSGRQSAYANKVSESVSDSAVAEAAAQAS
Mb0288|M.bovis_AF2122/97 QARARRRRRVTRRGYGDEFMDMNIDVDPDWGPPPG-EDPVTSTVASDRGA
Rv0280|M.tuberculosis_H37Rv QARARRRRRVTRRGYGDEFMDMNIDVDPDWGPPPG-EDPVTSTVASDRGA
MMAR_0538|M.marinum_M EARRRRRKRKTERGYGEEFMDV--EVDPDWGGPRD-DEP----VASTQGA
MUL_1202|M.ulcerans_Agy99 EARRRRRKRKTERGYGEEFMDV--EVDPDWGGPLD-DEP----VASTQGA
Mflv_0325|M.gilvum_PYR-GCK AERRKRRRRQKEEIKGRGYADAYADYEELPDDGPP-EQPAPRVTASTRGA
Mvan_0415|M.vanbaalenii_PYR-1 AERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPP-VRQEPRIAATERGA
MSMEG_0619|M.smegmatis_MC2_155 ASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPA-PQPEPRVRASERGS
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 AARQARRRRDKGKQQGRG-----IEYMDMNATARC-EEPAPDTTASHRGA
MAV_4872|M.avium_104 RARARRRRRAAMKDRYRG-----YEFMDVEPDAGP-EPETDSVTASDRGA
MLBr_00539|M.leprae_Br4923 AREQARAWRRRSAAKERGYREEVITMNTGFDAAIPSPVDQTGSRVSDCGA
Mb0288|M.bovis_AF2122/97 GHLGFAGTARREAVADAAGMTTLA-GDDFGDGPTTPMVPGSWDPDRDAPG
Rv0280|M.tuberculosis_H37Rv GHLGFAGTARREAVADAAGMTTLA-GDDFGDGPTTPMVPGSWDPDRDAPG
MMAR_0538|M.marinum_M GRLGFAGTVHSESAATAAGLTTLV-ADEFGGGPKMPMLPGTWDTDSDAPS
MUL_1202|M.ulcerans_Agy99 GRLGFAGTVHSESAATAAGLTTLV-ADEFGGGPKMPMLPGTWDTDSDAPS
Mflv_0325|M.gilvum_PYR-GCK GPMGFAGTVS-RGDEQAGGLTTLA-GDSFGGGPREPMLPGTWDPDATDDR
Mvan_0415|M.vanbaalenii_PYR-1 GPMGFAGTVS-RDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD-
MSMEG_0619|M.smegmatis_MC2_155 DAMGFTGTVT-RHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPA-
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0809c|M.abscessus_ATCC_199 GTMGFAGTVI-KTGATASGLAMLSRDDDLFEGVRAPMVPNTWDPEHGRQD
MAV_4872|M.avium_104 GPLGFAGTAP-SAPAQATGLATLA-GDEFGTGPSMPMVPGNWTGE-----
MLBr_00539|M.leprae_Br4923 GSFGFAGTVSKEAVVEVAGLTTLA-GDDFGGGPTMPMVPGTWAPARESSD
Mb0288|M.bovis_AF2122/97 SAEPGDRG---------
Rv0280|M.tuberculosis_H37Rv SAEPGDRG---------
MMAR_0538|M.marinum_M D----------------
MUL_1202|M.ulcerans_Agy99 D----------------
Mflv_0325|M.gilvum_PYR-GCK HTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 -----ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 -----PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu -----------------
MAB_0809c|M.abscessus_ATCC_199 -----------------
MAV_4872|M.avium_104 -----------------
MLBr_00539|M.leprae_Br4923 EGR--------------