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VWIALPPEINTARLMVGAGPAPMLQAAAGWEGLAVLLETQAAELAAALTNLTSVWTGAASERAVAATMPM ITWLQTTAAQAQKRALQASAQASSYSLALATTPPLPEIEQNHITHGVLEATNFLGINTVPIALNEMDYFV RMWNQAAGAMDVYHAETTVNLLFEPIMPMKPIVLPGVGETTAAAALAQTAPRVAEGVMRNAVIEGVSAIA TIESVGLAAGHAAAQANFAEQRGQGAAQKGENAGQEAGRESGKNMQQGMQMVMQMGSQAAQAPAQLASMF QSGVQTMTQPLQQATQMVSQFASMGGSERAMQVGLMGASPFSNHPMLGGSGPSTGAGLVRAMSLPGAGGT APRTPLLSNLLGISGEMKAAPAGAGSAAAGGLAPVGAGAGGGAGAPVAHAGQNSKSGGKKDGLVAPTPLT YDLSEDEDDEW
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0064 | - | - | 100% (431) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 4e-39 | 44.74% (190) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_5989 | - | 2e-36 | 34.08% (355) | hypothetical protein MSMEG_5989 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3903 | PPE68 | 1e-94 | 45.35% (441) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0768 | - | 1e-125 | 53.69% (434) | PPE protein |
| M. tuberculosis H37Rv | Rv3873 | PPE68 | 1e-94 | 45.35% (441) | PPE family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 2e-29 | 37.50% (192) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 2e-36 | 42.78% (194) | PPE family protein |
| M. marinum M | MMAR_5448 | - | 2e-91 | 46.21% (435) | PPE family protein |
| M. avium 104 | MAV_0118 | - | 1e-39 | 49.68% (157) | PPE family protein |
| M. thermoresistible (build 8) | TH_4447 | - | 1e-146 | 61.87% (438) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2932 | - | 6e-37 | 29.48% (424) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0077 | - | 1e-127 | 54.13% (436) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3903|M.bovis_AF2122/97 ---------MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQ
Rv3873|M.tuberculosis_H37Rv ---------MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQ
MMAR_5448|M.marinum_M ---------MLWHAMPPELNTARLMAGAGPAPMLAAAAGWEALAAALDAQ
Mflv_0768|M.gilvum_PYR-GCK MANIGIPVPPSWVAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
Mvan_0077|M.vanbaalenii_PYR-1 MATIGIPIPPIWGAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
TH_4447|M.thermoresistible__bu ---------MFWHAMPPEVNTSRLMAGAGTAPMLQAAAGWEAFAISLETQ
MSMEG_0064|M.smegmatis_MC2_155 ----------MWIALPPEINTARLMVGAGPAPMLQAAAGWEGLAVLLETQ
MAB_4783|M.abscessus_ATCC_1997 ------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTEYSSA
MAV_0118|M.avium_104 ------MTAPVWMALPPEVHSTLLSSGPGPGPLLAAAATWTGLSTQYDSA
MLBr_01828|M.leprae_Br4923 ------MSAPIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSLSSVYAEM
MUL_2932|M.ulcerans_Agy99 ------MTSPLWMASPPEVHSSLLSTGPGPGGILVAAAGWLSLGALFEAT
* * ***:::: * *.*. :: ** * :.
Mb3903|M.bovis_AF2122/97 AVELTARLN-SLGEAWTGGGSDKALAAATPMVVWLQTASTQAKTRAMQAT
Rv3873|M.tuberculosis_H37Rv AVELTARLN-SLGEAWTGGGSDKALAAATPMVVWLQTASTQAKTRAMQAT
MMAR_5448|M.marinum_M AVELTARLN-SLGEAWTGGGSEKALAAALPMVTWLQTASTQAKTRGLQAG
Mflv_0768|M.gilvum_PYR-GCK ADELASSLA-SLSQNWQGMASERAVTAAMPMVLWLRMLSLQAHKRALQAS
Mvan_0077|M.vanbaalenii_PYR-1 ADELAASLA-TLSQMWQGTASERAVMATMPMVMWLRMLSLQAQKRAAQAS
TH_4447|M.thermoresistible__bu ADELAGSLA-ALAGAWTGGASERAIAAITPMIVWLRTVSAQAHKRSAQAL
MSMEG_0064|M.smegmatis_MC2_155 AAELAAALT-NLTSVWTGAASERAVAATMPMITWLQTTAAQAQKRALQAS
MAB_4783|M.abscessus_ATCC_1997 ANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVAAQTE
MAV_0118|M.avium_104 ATELTAVLTGSMP-VWDGPTADRYVAAHMPYLAWLQLAGALSAEAAAQHQ
MLBr_01828|M.leprae_Br4923 ADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSAVMAAHYE
MUL_2932|M.ulcerans_Agy99 AAEVDHQIC-EAIRLWQGRAADDYVAAHTPYVVWLDHAAIVCQRAGAALQ
* *: : * * :: * * : ** . . .
Mb3903|M.bovis_AF2122/97 AQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYF
Rv3873|M.tuberculosis_H37Rv AQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYF
MMAR_5448|M.marinum_M AQAAAYMQAMATTPSLPEIFANHITNVILNATNFFGINTVPIAFNEMDYF
Mflv_0768|M.gilvum_PYR-GCK AQASSWTVAATGTPQLPEIELNHVTNATLHATNFLGVNGIPIALNEADY-
Mvan_0077|M.vanbaalenii_PYR-1 AQATAWASAATSTPQLPEIETNHITNAVLNATNFLGVNTVPIAVNEADY-
TH_4447|M.thermoresistible__bu AQAAAYSTAMATTPPLAEIEQNHITRAVLHATNFLGINTVPIGINEMDYF
MSMEG_0064|M.smegmatis_MC2_155 AQASSYSLALATTPPLPEIEQNHITHGVLEATNFLGINTVPIALNEMDYF
MAB_4783|M.abscessus_ATCC_1997 TAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNEADY-
MAV_0118|M.avium_104 GVATAYTAALAAMPTLPELAANHATHAALVATNFFGVNTIPIAVNEADY-
MLBr_01828|M.leprae_Br4923 TMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIARNEIDY-
MUL_2932|M.ulcerans_Agy99 MMVAAYGDALAEMPTMAELQENHAVHGVLVATNFFGLNGVPIAVNEADY-
.::: : : * : *: *: .. * :***:*:* :**. .* **
Mb3903|M.bovis_AF2122/97 IRMWNQAALAMEVYQAETAVN-----TLFEKLEPMASILDPGASQST---
Rv3873|M.tuberculosis_H37Rv IRMWNQAALAMEVYQAETAVN-----TLFEKLEPMASILDPGASQST---
MMAR_5448|M.marinum_M VRMWNQAALAMDVYQAETTAN-----TLFEQLEPMTSILDPATAQSMPT-
Mflv_0768|M.gilvum_PYR-GCK IRMWNQAAAVMTAYETETVLN-----TTFEPVAPPKPIAVPPGSEAAFAG
Mvan_0077|M.vanbaalenii_PYR-1 IRMWNQAAAVMTGYETETILN-----STFEPVAPPKPITVFGSTQAAMAT
TH_4447|M.thermoresistible__bu VRMWNQAAGAMDVYQAETAMN-----ILFEPIMPMKPIVIPGVGEAAVAG
MSMEG_0064|M.smegmatis_MC2_155 VRMWNQAAGAMDVYHAETTVN-----LLFEPIMPMKPIVLPGVGETTAAA
MAB_4783|M.abscessus_ATCC_1997 IRMWIQAATVMSTYQAVSE----SSVSAAPPTSPAPPVLSPDSGAAARTA
MAV_0118|M.avium_104 ARMWTQAATTMTTYQATTEAVQMTSVAGSGTGGKAGSGSGSGTGAGTGTG
MLBr_01828|M.leprae_Br4923 VRMWVEAAIAMGTYQEVST----VVVDSAPEAIAAPQIMASDALEASSDQ
MUL_2932|M.ulcerans_Agy99 VRMWIQAAGVMGVYESCTSAA----LLEVRPTCPSPVLVNPGVEGVGNAT
*** :** .* *. :
Mb3903|M.bovis_AF2122/97 --------------------------------------------------
Rv3873|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5448|M.marinum_M --------------------------------------------------
Mflv_0768|M.gilvum_PYR-GCK AMSGAVPGAG----------------------------------------
Mvan_0077|M.vanbaalenii_PYR-1 AIGSAAPGIA----------------------------------------
TH_4447|M.thermoresistible__bu ALGKAAAMAP----------------------------------------
MSMEG_0064|M.smegmatis_MC2_155 ALAQTAPRVA----------------------------------------
MAB_4783|M.abscessus_ATCC_1997 AQDATKPPP---------------------------IVPDPNDPIEMLLK
MAV_0118|M.avium_104 TGTGTGTGTGTGTGTGAGSGTGGGTGAGGGGGTGSFQLPTPEEIWEMLFG
MLBr_01828|M.leprae_Br4923 PSPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGMFS
MUL_2932|M.ulcerans_Agy99 SWSGFADSDE----------------------------------------
Mb3903|M.bovis_AF2122/97 -------------------------------------------------T
Rv3873|M.tuberculosis_H37Rv -------------------------------------------------T
MMAR_5448|M.marinum_M ------------------------------------------------SS
Mflv_0768|M.gilvum_PYR-GCK ---------------------------------------------EAVMR
Mvan_0077|M.vanbaalenii_PYR-1 ---------------------------------------------SAAAR
TH_4447|M.thermoresistible__bu ---------------------------------------------AAAAR
MSMEG_0064|M.smegmatis_MC2_155 ---------------------------------------------EGVMR
MAB_4783|M.abscessus_ATCC_1997 -------------------------------------NSQHFLGMYRALK
MAV_0118|M.avium_104 PDGEQIPGQGQPNWSPSEY--------LQNLGNFFNGNAQAVAWLQQNLS
MLBr_01828|M.leprae_Br4923 GFDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIGADLA
MUL_2932|M.ulcerans_Agy99 -------------------------------------------FSVSSFN
Mb3903|M.bovis_AF2122/97 NPIFGMPSPGSSTPVG----------------------------------
Rv3873|M.tuberculosis_H37Rv NPIFGMPSPGSSTPVG----------------------------------
MMAR_5448|M.marinum_M TPLLDMASQVTGIPSS----------------------------------
Mflv_0768|M.gilvum_PYR-GCK NAIISKVSSTAKLDTANQIAG-----------RAEGTLRGVVDRAGSHAE
Mvan_0077|M.vanbaalenii_PYR-1 NATFTKVSVVGKLDEVNQKAG-----------HAEGLLQQAADSGRSQAE
TH_4447|M.thermoresistible__bu DLVFAKVSAQATVESAALQAGRAVAQGNMAAQRAEGTVQKTENLAHQSAT
MSMEG_0064|M.smegmatis_MC2_155 NAVIEGVSAIATIESVGLAAG-----------HAAAQANFAEQRGQGAAQ
MAB_4783|M.abscessus_ATCC_1997 GLITDPVGTIVRIIIDFSTNPAA-AIVTWTP--LFYVFAYAATFAVMGTP
MAV_0118|M.avium_104 GLLNP--SQFPALINYFIAWQTY-RIINWTIRTLRFILQELPLLLQVGLS
MLBr_01828|M.leprae_Br4923 AAFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPMILP
MUL_2932|M.ulcerans_Agy99 DGVLGLDVAVAGELCEFDPFDG----------------------------
Mb3903|M.bovis_AF2122/97 -------------------------QLPPAATQTLGQLGEMSG-PMQQLT
Rv3873|M.tuberculosis_H37Rv -------------------------QLPPAATQTLGQLGEMSG-PMQQLT
MMAR_5448|M.marinum_M -------------------------ELQQTATQ----VAEASG-PMQQLA
Mflv_0768|M.gilvum_PYR-GCK KSQGLEQAPQ----QGMQMGMQMASQLGSTLGQMPQQMMQGVTQPFQQLT
Mvan_0077|M.vanbaalenii_PYR-1 QGQLLQQAPQ----QGMQMGMQMASQLGSTLGQLPQQMMQGVTQPFQQLT
TH_4447|M.thermoresistible__bu RSE--PQQLQ----QGVQMGMQMGSQLGSTLAQLPQQAGQMISQPMQQLT
MSMEG_0064|M.smegmatis_MC2_155 KGENAGQEAGRESGKNMQQGMQMVMQMGSQAAQAPAQLASMFQSGVQTMT
MAB_4783|M.abscessus_ATCC_1997 IYAAIMG-PAAGIS-------IPLAITLASLSQMPEAPPVDAPAETVPAR
MAV_0118|M.avium_104 LSITSLG-GLAGLAGLAGLAGLAAPASAPAPAAMPQPAGMGAQPPVVSAA
MLBr_01828|M.leprae_Br4923 LLTAPLAVATAGAAGSFAGLSELAGLVGVAPPGLPSAPPVAAVAPVVPP-
MUL_2932|M.ulcerans_Agy99 -------------------------LDLDGCQLVSVSTTQGFGAAMDVTA
Mb3903|M.bovis_AF2122/97 QPLQQVTSLFSQVGGTGGGNPADEEAAQMGLLGTSPLSNHPLAGGS----
Rv3873|M.tuberculosis_H37Rv QPLQQVTSLFSQVGGTGGGNPADEEAAQMGLLGTSPLSNHPLAGGS----
MMAR_5448|M.marinum_M QPAQQMTSAFSNTGSSGNG--ADEEGFRMGLLGAGALSNHPLAGGS----
Mflv_0768|M.gilvum_PYR-GCK QPLQQMSSLFGGM--MNGD----K-GAQIGMVGATPFSNHPAIGGT----
Mvan_0077|M.vanbaalenii_PYR-1 QPLQQMSSLFGQMGGLGGD----R-GAQIGMLGATPFSNHPAIGGS----
TH_4447|M.thermoresistible__bu APLQQVSSVFGQMGGMGSG----D-SAQIGLIGASPFSNHPLAGGS----
MSMEG_0064|M.smegmatis_MC2_155 QPLQQATQMVSQFASMGGS----ERAMQVGLMGASPFSNHPMLGGS----
MAB_4783|M.abscessus_ATCC_1997 IDQPHAVAMGGAPAPTASTAAPTPTTTSPATPGSAPAPTPPPAGAEGLGY
MAV_0118|M.avium_104 PAMAPMAPTSPVAPATSAVSTPAPVASAIAPPATPPVPPAPVTGAEGFGY
MLBr_01828|M.leprae_Br4923 -SMPTLASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPSVTGAGVESFGY
MUL_2932|M.ulcerans_Agy99 APGSPLSGAALAPTGHICAGVPLATSTPLGVTRHVGDLQMMAARDNS---
.
Mb3903|M.bovis_AF2122/97 -----------GPSAGAGLLRAESLPGAGGSLTRTPLMSQLIE---KPVA
Rv3873|M.tuberculosis_H37Rv -----------GPSAGAGLLRAESLPGAGGSLTRTPLMSQLIE---KPVA
MMAR_5448|M.marinum_M -----------GPTTGAGLLRGESLPGAGGTLTRTPLISELVE---KPMG
Mflv_0768|M.gilvum_PYR-GCK -----------GPATGSGLVRAASLPGAGGSAPQTPLMSNLVGSGLQPT-
Mvan_0077|M.vanbaalenii_PYR-1 -----------GAATGAGLVRAASLPGAGGTAARTPLMSNLVGSGLQPTV
TH_4447|M.thermoresistible__bu -----------GPATGAGLVRAASLPGLGGTSPTTSLISNLLG-HQNPTA
MSMEG_0064|M.smegmatis_MC2_155 -----------GPSTGAGLVRAMSLPGAGGTAPRTPLLSNLLG----ISG
MAB_4783|M.abscessus_ATCC_1997 AVRGDGPGFGFGPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRR
MAV_0118|M.avium_104 MVGSFGLGMDSKAQTRARSALAAGRP--AASSAGAAAVEQEQGRTRRRPR
MLBr_01828|M.leprae_Br4923 LVG--RLPSTARGVVGTSVRQQSSAP-DRIEAPDAAATPQEQARSRWRRR
MUL_2932|M.ulcerans_Agy99 -----------DRAVVDAPHEILVSDSRGGTAQSGASGSVRPGVGSASVV
Mb3903|M.bovis_AF2122/97 PSVMP--------------------AAAAGSSATGGAAPVGAGA------
Rv3873|M.tuberculosis_H37Rv PSVMP--------------------AAAAGSSATGGAAPVGAGA------
MMAR_5448|M.marinum_M PSVQP--------------------AAAAGSSASSGAAPVGAGG------
Mflv_0768|M.gilvum_PYR-GCK SPVAV--------------------GAGAGPGAGVGLAPVGTGGGMGAGG
Mvan_0077|M.vanbaalenii_PYR-1 SAVAV--------------------GAGAGAGAGAGLAPVGAGSGMGGGG
TH_4447|M.thermoresistible__bu APAPT--------------------GAVAG-GAGTGPAPIG-GGGMG--A
MSMEG_0064|M.smegmatis_MC2_155 EMKAA--------------------PAGAGSAAAGGLAPVGAGAGGGAGA
MAB_4783|M.abscessus_ATCC_1997 RTIDDRGYRHEYATMDD-HTPTGPQDPVTAVASGTGAGRLGFAGVHTATT
MAV_0118|M.avium_104 SVIDP-GYRYEFIEGDDEVVAVASAAQDRYRPSDSGGSIQGFAGTLPKS-
MLBr_01828|M.leprae_Br4923 AKVTP------------FDSSGSPNPKAAPTASDQGAGTLGLAGTARQAS
MUL_2932|M.ulcerans_Agy99 QAASP-------------------GRPVSELAGGRGAGTVGFAGVSATGT
. * . * ..
Mb3903|M.bovis_AF2122/97 -MGQGAQS--GGSTRPGLVAPAPLAQEREEDDEDDWDEEDDW--------
Rv3873|M.tuberculosis_H37Rv -MGQGAQS--GGSTRPGLVAPAPLAQEREEDDEDDWDEEDDW--------
MMAR_5448|M.marinum_M -MGAGAGAGAGGSSRPGMAAPATLTQERDEADEDDWDDEDDW--------
Mflv_0768|M.gilvum_PYR-GCK PMGMFGQRGKSGGNKPGLNAPAPLDHDLGEDEDEEW--------------
Mvan_0077|M.vanbaalenii_PYR-1 PMGMLGQRGKSGGNKPGLNAPAPLEHDLSEDDDDDW--------------
TH_4447|M.thermoresistible__bu PMAAMGQNQKSGGSKSGLKAPAPLVQDLSEDEGDDW--------------
MSMEG_0064|M.smegmatis_MC2_155 PVAHAGQNSKSGGKKDGLVAPTPLTYDLSEDEDDEW--------------
MAB_4783|M.abscessus_ATCC_1997 AVEATGLSTLDG--DAENRTIPMLPGTWDVTDDDR---------------
MAV_0118|M.avium_104 GVRASGLNTLAGNESGDGARIPMLPESWDGP-------------------
MLBr_01828|M.leprae_Br4923 SGPATGLVTLSNGTFSDSPRAPMLPRTWGADPTFCYNAADIGPAGGWDDE
MUL_2932|M.ulcerans_Agy99 KVRPAGLSATGGGEFGSGAGVPVLPATWPLQVVGSTSGSGVSPPAL----
. . . *