For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MLWHAMPPELNTARLMAGAGPAPMLAAAAGWEALAAALDAQAVELTARLNSLGEAWTGGGSEKALAAALP MVTWLQTASTQAKTRGLQAGAQAAAYMQAMATTPSLPEIFANHITNVILNATNFFGINTVPIAFNEMDYF VRMWNQAALAMDVYQAETTANTLFEQLEPMTSILDPATAQSMPTSSTPLLDMASQVTGIPSSELQQTATQ VAEASGPMQQLAQPAQQMTSAFSNTGSSGNGADEEGFRMGLLGAGALSNHPLAGGSGPTTGAGLLRGESL PGAGGTLTRTPLISELVEKPMGPSVQPAAAAGSSASSGAAPVGAGGMGAGAGAGAGGSSRPGMAAPATLT QERDEADEDDWDDEDDW
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_5448 | - | - | 100% (367) | PPE family protein |
| M. marinum M | MMAR_0186 | - | e-118 | 61.44% (376) | PPE family protein |
| M. marinum M | MMAR_5417 | - | e-114 | 59.25% (373) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3903 | PPE68 | 1e-155 | 73.73% (373) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0768 | - | 8e-82 | 42.36% (432) | PPE protein |
| M. tuberculosis H37Rv | Rv3873 | PPE68 | 1e-155 | 73.73% (373) | PPE family protein |
| M. leprae Br4923 | MLBr_00051 | - | 2e-48 | 44.53% (265) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2230c | - | 5e-35 | 41.58% (202) | PPE family protein |
| M. avium 104 | MAV_0118 | - | 8e-37 | 47.17% (159) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0064 | - | 1e-91 | 46.14% (440) | PPE family protein |
| M. thermoresistible (build 8) | TH_4447 | - | 8e-91 | 45.79% (439) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1208 | - | 3e-34 | 33.16% (395) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0077 | - | 5e-85 | 44.11% (433) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3903|M.bovis_AF2122/97 ---------MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQ
Rv3873|M.tuberculosis_H37Rv ---------MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQ
MMAR_5448|M.marinum_M ---------MLWHAMPPELNTARLMAGAGPAPMLAAAAGWEALAAALDAQ
Mflv_0768|M.gilvum_PYR-GCK MANIGIPVPPSWVAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
Mvan_0077|M.vanbaalenii_PYR-1 MATIGIPIPPIWGAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
TH_4447|M.thermoresistible__bu ---------MFWHAMPPEVNTSRLMAGAGTAPMLQAAAGWEAFAISLETQ
MSMEG_0064|M.smegmatis_MC2_155 ----------MWIALPPEINTARLMVGAGPAPMLQAAAGWEGLAVLLETQ
MLBr_00051|M.leprae_Br4923 --------------------MTWPMLWPASVPSECPPNYWHTPAPSAKCE
MAB_2230c|M.abscessus_ATCC_199 ------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSVQYTTA
MUL_1208|M.ulcerans_Agy99 ---MAVAAGPIWIASPPEVHSAMLSSGPGPASLLAAAGVWSALSAEYALT
MAV_0118|M.avium_104 ------MTAPVWMALPPEVHSTLLSSGPGPGPLLAAAATWTGLSTQYDSA
: ... . .. * :
Mb3903|M.bovis_AF2122/97 AVELTARLNSLGE-AWTGGGSDKALAAATPMVVWLQTASTQAKTRAMQAT
Rv3873|M.tuberculosis_H37Rv AVELTARLNSLGE-AWTGGGSDKALAAATPMVVWLQTASTQAKTRAMQAT
MMAR_5448|M.marinum_M AVELTARLNSLGE-AWTGGGSEKALAAALPMVTWLQTASTQAKTRGLQAG
Mflv_0768|M.gilvum_PYR-GCK ADELASSLASLSQ-NWQGMASERAVTAAMPMVLWLRMLSLQAHKRALQAS
Mvan_0077|M.vanbaalenii_PYR-1 ADELAASLATLSQ-MWQGTASERAVMATMPMVMWLRMLSLQAQKRAAQAS
TH_4447|M.thermoresistible__bu ADELAGSLAALAG-AWTGGASERAIAAITPMIVWLRTVSAQAHKRSAQAL
MSMEG_0064|M.smegmatis_MC2_155 AAELAAALTNLTS-VWTGAASERAVAATMPMITWLQTTAAQAQKRALQAS
MLBr_00051|M.leprae_Br4923 PEQAAVAP----------------IAAAKPMITWLQSAAEQTTT------
MAB_2230c|M.abscessus_ATCC_199 ATELTQLLAATGSGSWQGPSAAQYVASHAPYLAWLTQQSAMSATNAVLHE
MUL_1208|M.ulcerans_Agy99 AAELSEVLAAVQAGAWQGPSGFQYVAAHLPYVAWLLQASADGAGKAAEHE
MAV_0118|M.avium_104 ATELTAVLTGSMP-VWDGPTADRYVAAHMPYLAWLQLAGALSAEAAAQHQ
. : : : : * : ** .
Mb3903|M.bovis_AF2122/97 AQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYF
Rv3873|M.tuberculosis_H37Rv AQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYF
MMAR_5448|M.marinum_M AQAAAYMQAMATTPSLPEIFANHITNVILNATNFFGINTVPIAFNEMDYF
Mflv_0768|M.gilvum_PYR-GCK AQASSWTVAATGTPQLPEIELNHVTNATLHATNFLGVNGIPIALNEADY-
Mvan_0077|M.vanbaalenii_PYR-1 AQATAWASAATSTPQLPEIETNHITNAVLNATNFLGVNTVPIAVNEADY-
TH_4447|M.thermoresistible__bu AQAAAYSTAMATTPPLAEIEQNHITRAVLHATNFLGINTVPIGINEMDYF
MSMEG_0064|M.smegmatis_MC2_155 AQASSYSLALATTPPLPEIEQNHITHGVLEATNFLGINTVPIALNEMDYF
MLBr_00051|M.leprae_Br4923 -QAEAHRQAMASTPGMAVITENHITQAILATINFFGINMAPIAFTEAGDF
MAB_2230c|M.abscessus_ATCC_199 TSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNEADY-
MUL_1208|M.ulcerans_Agy99 AAAVAYSGALAAMPTLTELGANHALHGVLVATNFFGLNAIPIALNEADY-
MAV_0118|M.avium_104 GVATAYTAALAAMPTLPELAANHATHAALVATNFFGVNTIPIAVNEADY-
* : * : * :. : ** . * : **:*:* **...* .
Mb3903|M.bovis_AF2122/97 IRMWNQAALAMEVYQAETAVN--TLFEKLEPMASILDPGASQST------
Rv3873|M.tuberculosis_H37Rv IRMWNQAALAMEVYQAETAVN--TLFEKLEPMASILDPGASQST------
MMAR_5448|M.marinum_M VRMWNQAALAMDVYQAETTAN--TLFEQLEPMTSILDPATAQSMPT----
Mflv_0768|M.gilvum_PYR-GCK IRMWNQAAAVMTAYETETVLN--TTFEPVAPPKPIAVPPGSEAAFAGAMS
Mvan_0077|M.vanbaalenii_PYR-1 IRMWNQAAAVMTGYETETILN--STFEPVAPPKPITVFGSTQAAMATAIG
TH_4447|M.thermoresistible__bu VRMWNQAAGAMDVYQAETAMN--ILFEPIMPMKPIVIPGVGEAAVAGALG
MSMEG_0064|M.smegmatis_MC2_155 VRMWNQAAGAMDVYHAETTVN--LLFEPIMPMKPIVLPGVGETTAAAALA
MLBr_00051|M.leprae_Br4923 ICMRTQTALAMNSYQAETLLN--TAFQKLEPMAAILNPSSYSPPS-----
MAB_2230c|M.abscessus_ATCC_199 IRMWIQAATTMGVYQGVSTAA-VTSVAPTPPAPTIMAPGG-EMSRMSADM
MUL_1208|M.ulcerans_Agy99 VRMWVQAATTMGLYQATAGAA-LASAPRTGPPPKVVNPGGGQVAHLAADA
MAV_0118|M.avium_104 ARMWTQAATTMTTYQATTEAVQMTSVAGSGTGGKAGSGSGSGTGAGTGTG
* *:* .* *. : .
Mb3903|M.bovis_AF2122/97 --------------------------------------------------
Rv3873|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5448|M.marinum_M --------------------------------------------------
Mflv_0768|M.gilvum_PYR-GCK GAVPGAGEAVMRN-------------------------------------
Mvan_0077|M.vanbaalenii_PYR-1 SAAPGIASAAARN-------------------------------------
TH_4447|M.thermoresistible__bu KAAAMAPAAAARD-------------------------------------
MSMEG_0064|M.smegmatis_MC2_155 QTAPRVAEGVMRN-------------------------------------
MLBr_00051|M.leprae_Br4923 --------------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 SGMAAQAQAAESG-----------MALDD---SESFFDKLMRQIQEFFSD
MUL_1208|M.ulcerans_Agy99 ARAQSGAAAAGGSDPWQLLWQLLQYLWNA---YTGFNTWMFDLIWEFLQD
MAV_0118|M.avium_104 TGTGTGTGTGTGTGTGAGSGTGGGTGAGGGGGTGSFQLPTPEEIWEMLFG
Mb3903|M.bovis_AF2122/97 ----------------------------------------TNPIFGMPSP
Rv3873|M.tuberculosis_H37Rv ----------------------------------------TNPIFGMPSP
MMAR_5448|M.marinum_M ---------------------------------------SSTPLLDMASQ
Mflv_0768|M.gilvum_PYR-GCK ---------------------------------AIISKVSSTAKLDTANQ
Mvan_0077|M.vanbaalenii_PYR-1 ---------------------------------ATFTKVSVVGKLDEVNQ
TH_4447|M.thermoresistible__bu ---------------------------------LVFAKVSAQATVESAAL
MSMEG_0064|M.smegmatis_MC2_155 ---------------------------------AVIEGVSAIATIESVGL
MLBr_00051|M.leprae_Br4923 ---------------------------------------ALTSQVNQFTQ
MAB_2230c|M.abscessus_ATCC_199 P---------------------LGTLQK---ILQDFMRNPLEALVAWGPL
MUL_1208|M.ulcerans_Agy99 P---------------------IGNTIK---IIIAFLTNPLQAIITYGPL
MAV_0118|M.avium_104 PDGEQIPGQGQPNWSPSEYLQNLGNFFNGNAQAVAWLQQNLSGLLNPSQF
.
Mb3903|M.bovis_AF2122/97 GSS-----------------------------------------------
Rv3873|M.tuberculosis_H37Rv GSS-----------------------------------------------
MMAR_5448|M.marinum_M VTG-----------------------------------------------
Mflv_0768|M.gilvum_PYR-GCK IAG-----------RAEGTLRGVVDRAGSHAEKSQGLEQAPQ--------
Mvan_0077|M.vanbaalenii_PYR-1 KAG-----------HAEGLLQQAADSGRSQAEQGQLLQQAPQ--------
TH_4447|M.thermoresistible__bu QAGRAVAQGNMAAQRAEGTVQKTENLAHQSATRSE--PQQLQ--------
MSMEG_0064|M.smegmatis_MC2_155 AAG-----------HAAAQANFAEQRGQGAAQKGENAGQEAGRESG----
MLBr_00051|M.leprae_Br4923 MIS-----------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 LFFIAYEAFFIPFGFTFWGV------MLSAPLWLPLLLVGLAQLVN----
MUL_1208|M.ulcerans_Agy99 LFALSYQIFFNLVGWPTWAL------ILSSPFLLPAALGLALSAIA----
MAV_0118|M.avium_104 PALINYFIAWQTYRIINWTIRTLRFILQELPLLLQVGLSLSITSLGGLAG
Mb3903|M.bovis_AF2122/97 -------------------------TPVGQLPPAATQTLGQLGEMSG-PM
Rv3873|M.tuberculosis_H37Rv -------------------------TPVGQLPPAATQTLGQLGEMSG-PM
MMAR_5448|M.marinum_M -------------------------IPSSELQQTATQ----VAEASG-PM
Mflv_0768|M.gilvum_PYR-GCK ------------------QGMQMGMQMASQLGSTLGQMPQQMMQGVTQPF
Mvan_0077|M.vanbaalenii_PYR-1 ------------------QGMQMGMQMASQLGSTLGQLPQQMMQGVTQPF
TH_4447|M.thermoresistible__bu ------------------QGVQMGMQMGSQLGSTLAQLPQQAGQMISQPM
MSMEG_0064|M.smegmatis_MC2_155 ------------------KNMQQGMQMVMQMGSQAAQAPAQLASMFQSGV
MLBr_00051|M.leprae_Br4923 -----------------------GFSAALPSTQVLQQTVGQVAELAR-PM
MAB_2230c|M.abscessus_ATCC_199 ----------PVPVEADAPADEPAPQQARVERSSPQQQPFAMGGMPGGGG
MUL_1208|M.ulcerans_Agy99 ----------FTPIQIAAEVPAAAAPLAAAAVTAKSVFPAASLASPGTG-
MAV_0118|M.avium_104 LAGLAGLAGLAAPASAPAPAAMPQPAGMGAQPPVVSAAPAMAPMAPTSPV
Mb3903|M.bovis_AF2122/97 QQLTQPLQQVTSLFSQVGGTGGGNPADEEAAQMGLLGTSPLSNHPLAGGS
Rv3873|M.tuberculosis_H37Rv QQLTQPLQQVTSLFSQVGGTGGGNPADEEAAQMGLLGTSPLSNHPLAGGS
MMAR_5448|M.marinum_M QQLAQPAQQMTSAFSNTGSSGNG--ADEEGFRMGLLGAGALSNHPLAGGS
Mflv_0768|M.gilvum_PYR-GCK QQLTQPLQQMSSLFGGM--MNGD----K-GAQIGMVGATPFSNHPAIGGT
Mvan_0077|M.vanbaalenii_PYR-1 QQLTQPLQQMSSLFGQMGGLGGD----R-GAQIGMLGATPFSNHPAIGGS
TH_4447|M.thermoresistible__bu QQLTAPLQQVSSVFGQMGGMGSG----D-SAQIGLIGASPFSNHPLAGGS
MSMEG_0064|M.smegmatis_MC2_155 QTMTQPLQQATQMVSQFASMGGS----ERAMQVGLMGASPFSNHPMLGGS
MLBr_00051|M.leprae_Br4923 QQVKSLFTSIDSTGVYTSAQRGD---TESAHRIGLFGASTLSSHPLVGIT
MAB_2230c|M.abscessus_ATCC_199 APATPANAPATPANAPASPAAAAATPAYMVYAVQ-EDPPAARFGPTLNEG
MUL_1208|M.ulcerans_Agy99 SAGAPASGAGAGAPGTAPPGPGAPAPASFLYAVGGSGDWGPSLGPTVGGR
MAV_0118|M.avium_104 APATSAVSTPAPVASAIAPPATPPVPPAPVTGAEGFGYMVGSFGLGMDSK
. .
Mb3903|M.bovis_AF2122/97 GPSAGAGLLRA-------ESLPGAGGSLTRTPLMSQLIE-----------
Rv3873|M.tuberculosis_H37Rv GPSAGAGLLRA-------ESLPGAGGSLTRTPLMSQLIE-----------
MMAR_5448|M.marinum_M GPTTGAGLLRG-------ESLPGAGGTLTRTPLISELVE-----------
Mflv_0768|M.gilvum_PYR-GCK GPATGSGLVRA-------ASLPGAGGSAPQTPLMSNLVGS----------
Mvan_0077|M.vanbaalenii_PYR-1 GAATGAGLVRA-------ASLPGAGGTAARTPLMSNLVGS----------
TH_4447|M.thermoresistible__bu GPATGAGLVRA-------ASLPGLGGTSPTTSLISNLLG-----------
MSMEG_0064|M.smegmatis_MC2_155 GPSTGAGLVRA-------MSLPGAGGTAPRTPLLSNLLG-----------
MLBr_00051|M.leprae_Br4923 GTTTDTRLLCA-------ESLPSASGSLAWTPLMTQFQL-----------
MAB_2230c|M.abscessus_ATCC_199 SGAKAPAAGIS------AAAAAAAS-ARSRARRKRGARIK-DPAPQFMDM
MUL_1208|M.ulcerans_Agy99 SGAKAPAVTIP------AAGAAAASRASARSRRRRRTEMR-DYGDEFLDM
MAV_0118|M.avium_104 AQTRARSALAAGRPAASSAGAAAVEQEQGRTRRRPRSVIDPGYRYEFIEG
. : . .. :
Mb3903|M.bovis_AF2122/97 ------KPVAPSVMPAAAAGSSATGGAAPVGAGA-------MGQGAQS--
Rv3873|M.tuberculosis_H37Rv ------KPVAPSVMPAAAAGSSATGGAAPVGAGA-------MGQGAQS--
MMAR_5448|M.marinum_M ------KPMGPSVQPAAAAGSSASSGAAPVGAGG-------MGAGAGAGA
Mflv_0768|M.gilvum_PYR-GCK ----GLQPT-SPVAVGAGAGPGAGVGLAPVGTGGGMGAGGPMGMFGQRGK
Mvan_0077|M.vanbaalenii_PYR-1 ----GLQPTVSAVAVGAGAGAGAGAGLAPVGAGSGMGGGGPMGMLGQRGK
TH_4447|M.thermoresistible__bu ----HQNPTAAPAPTGAVAG-GAGTGPAPIG-GGGMG--APMAAMGQNQK
MSMEG_0064|M.smegmatis_MC2_155 -------ISGEMKAAPAGAGSAAAGGLAPVGAGAGGGAGAPVAHAGQNSK
MLBr_00051|M.leprae_Br4923 ------------IDKSIAPEPRQRVMLPPWAAGS----------PGHNAQ
MAB_2230c|M.abscessus_ATCC_199 NSPVDPDFSEPATRHTAGVGASGRGAGQLGFAGTLPRTTSTTSAAGLIER
MUL_1208|M.ulcerans_Agy99 DA---NGVTGPAATDDAAR-ASERGAGQFGFAGTVS-TEAVLQAAGLTEL
MAV_0118|M.avium_104 DD----EVVAVASAAQDRYRPSDSGGSIQGFAGTLP--KSGVRASGLNTL
* .
Mb3903|M.bovis_AF2122/97 GGSTRPGLVAPAPLAQEREEDDEDDWDEEDDW-----------------
Rv3873|M.tuberculosis_H37Rv GGSTRPGLVAPAPLAQEREEDDEDDWDEEDDW-----------------
MMAR_5448|M.marinum_M GGSSRPGMAAPATLTQERDEADEDDWDDEDDW-----------------
Mflv_0768|M.gilvum_PYR-GCK SGGNKPGLNAPAPLDHDLGEDEDEEW-----------------------
Mvan_0077|M.vanbaalenii_PYR-1 SGGNKPGLNAPAPLEHDLSEDDDDDW-----------------------
TH_4447|M.thermoresistible__bu SGGSKSGLKAPAPLVQDLSEDEGDDW-----------------------
MSMEG_0064|M.smegmatis_MC2_155 SGGKKDGLVAPTPLTYDLSEDEDDEW-----------------------
MLBr_00051|M.leprae_Br4923 DGGTT--------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 EAASEMDGTRTVPMLPTSWGTDPEPDPDRAPSVPAPDEDWPPGERGAST
MUL_1208|M.ulcerans_Agy99 AVDEFGNGPR-MPMVPGSWDSPQEGREDGLQSE----------------
MAV_0118|M.avium_104 AGNESGDGAR-IPMLPESWDGP---------------------------