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MATIGIPIPPIWGAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQADELAASLATLSQMWQGTAS ERAVMATMPMVMWLRMLSLQAQKRAAQASAQATAWASAATSTPQLPEIETNHITNAVLNATNFLGVNTVP IAVNEADYIRMWNQAAAVMTGYETETILNSTFEPVAPPKPITVFGSTQAAMATAIGSAAPGIASAAARNA TFTKVSVVGKLDEVNQKAGHAEGLLQQAADSGRSQAEQGQLLQQAPQQGMQMGMQMASQLGSTLGQLPQQ MMQGVTQPFQQLTQPLQQMSSLFGQMGGLGGDRGAQIGMLGATPFSNHPAIGGSGAATGAGLVRAASLPG AGGTAARTPLMSNLVGSGLQPTVSAVAVGAGAGAGAGAGLAPVGAGSGMGGGGPMGMLGQRGKSGGNKPG LNAPAPLEHDLSEDDDDDW
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0077 | - | - | 100% (439) | PPE protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 3e-36 | 38.79% (214) | PPE protein |
| M. vanbaalenii PYR-1 | Mvan_0090 | - | 2e-14 | 25.24% (424) | hypothetical protein Mvan_0090 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3903 | PPE68 | 3e-89 | 43.81% (436) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0768 | - | 0.0 | 78.36% (439) | PPE protein |
| M. tuberculosis H37Rv | Rv3873 | PPE68 | 3e-89 | 43.81% (436) | PPE family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 5e-31 | 38.73% (173) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2230c | - | 6e-34 | 30.79% (406) | PPE family protein |
| M. marinum M | MMAR_5448 | - | 5e-83 | 43.96% (439) | PPE family protein |
| M. avium 104 | MAV_2928 | - | 6e-42 | 32.63% (426) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0064 | - | 1e-127 | 54.13% (436) | PPE family protein |
| M. thermoresistible (build 8) | TH_4447 | - | 1e-137 | 58.86% (440) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3127 | - | 1e-34 | 40.10% (192) | PPE family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3903|M.bovis_AF2122/97 ---------MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQ
Rv3873|M.tuberculosis_H37Rv ---------MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQ
MMAR_5448|M.marinum_M ---------MLWHAMPPELNTARLMAGAGPAPMLAAAAGWEALAAALDAQ
Mvan_0077|M.vanbaalenii_PYR-1 MATIGIPIPPIWGAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
Mflv_0768|M.gilvum_PYR-GCK MANIGIPVPPSWVAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
MSMEG_0064|M.smegmatis_MC2_155 ----------MWIALPPEINTARLMVGAGPAPMLQAAAGWEGLAVLLETQ
TH_4447|M.thermoresistible__bu ---------MFWHAMPPEVNTSRLMAGAGTAPMLQAAAGWEAFAISLETQ
MLBr_01828|M.leprae_Br4923 ------MSAPIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSLSSVYAEM
MUL_3127|M.ulcerans_Agy99 ------MTASVWIAWPPEVLSSALWSGSGPGPLFTAAAAWGSLGAEYATA
MAB_2230c|M.abscessus_ATCC_199 ------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSVQYTTA
MAV_2928|M.avium_104 --------MFDFGALPPEINSGRMYAGPGSGPLMAAAAAWDEVAAELGIA
: * ***: :. : *.*. .:: ** * ..
Mb3903|M.bovis_AF2122/97 AVELTARLNSLG-EAWTGGGSDKALAAATPMVVWLQTASTQAKTRAMQAT
Rv3873|M.tuberculosis_H37Rv AVELTARLNSLG-EAWTGGGSDKALAAATPMVVWLQTASTQAKTRAMQAT
MMAR_5448|M.marinum_M AVELTARLNSLG-EAWTGGGSEKALAAALPMVTWLQTASTQAKTRGLQAG
Mvan_0077|M.vanbaalenii_PYR-1 ADELAASLATLS-QMWQGTASERAVMATMPMVMWLRMLSLQAQKRAAQAS
Mflv_0768|M.gilvum_PYR-GCK ADELASSLASLS-QNWQGMASERAVTAAMPMVLWLRMLSLQAHKRALQAS
MSMEG_0064|M.smegmatis_MC2_155 AAELAAALTNLT-SVWTGAASERAVAATMPMITWLQTTAAQAQKRALQAS
TH_4447|M.thermoresistible__bu ADELAGSLAALA-GAWTGGASERAIAAITPMIVWLRTVSAQAHKRSAQAL
MLBr_01828|M.leprae_Br4923 ADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSAVMAAHYE
MUL_3127|M.ulcerans_Agy99 AEELAAELAGMQVGAWQGPGAESCMAAYLPYLQWLAQNSTVCGESAAQLE
MAB_2230c|M.abscessus_ATCC_199 ATELTQLLAATGSGSWQGPSAAQYVASHAPYLAWLTQQSAMSATNAVLHE
MAV_2928|M.avium_104 ASGYHSVIAELTSGPWVGPASLSMVSAITPYVGWLSAVAAQAEETASQGR
* : * * .: : : * : ** : . .
Mb3903|M.bovis_AF2122/97 AQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYF
Rv3873|M.tuberculosis_H37Rv AQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYF
MMAR_5448|M.marinum_M AQAAAYMQAMATTPSLPEIFANHITNVILNATNFFGINTVPIAFNEMDYF
Mvan_0077|M.vanbaalenii_PYR-1 AQATAWASAATSTPQLPEIETNHITNAVLNATNFLGVNTVPIAVNEADY-
Mflv_0768|M.gilvum_PYR-GCK AQASSWTVAATGTPQLPEIELNHVTNATLHATNFLGVNGIPIALNEADY-
MSMEG_0064|M.smegmatis_MC2_155 AQASSYSLALATTPPLPEIEQNHITHGVLEATNFLGINTVPIALNEMDYF
TH_4447|M.thermoresistible__bu AQAAAYSTAMATTPPLAEIEQNHITRAVLHATNFLGINTVPIGINEMDYF
MLBr_01828|M.leprae_Br4923 TMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIARNEIDY-
MUL_3127|M.ulcerans_Agy99 IVATAYISALAAMPTLTELAANHTTHAVLLGTNFFGINTIPIALNEADY-
MAB_2230c|M.abscessus_ATCC_199 TSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNEADY-
MAV_2928|M.avium_104 AAAAAFEAAFAMTVPPPVIAANRVLLATLVATNFFGQNTPAIAATEAQY-
*::: : : . : *: * ***:* * .*. .* :*
Mb3903|M.bovis_AF2122/97 IRMWNQAALAMEVYQAETAVNTLFEKLEPMASILDPGAS-----------
Rv3873|M.tuberculosis_H37Rv IRMWNQAALAMEVYQAETAVNTLFEKLEPMASILDPGAS-----------
MMAR_5448|M.marinum_M VRMWNQAALAMDVYQAETTANTLFEQLEPMTSILDPATA-----------
Mvan_0077|M.vanbaalenii_PYR-1 IRMWNQAAAVMTGYETETILNSTFEPVAPPKPITVFGST-----------
Mflv_0768|M.gilvum_PYR-GCK IRMWNQAAAVMTAYETETVLNTTFEPVAPPKPIAVPPGS-----------
MSMEG_0064|M.smegmatis_MC2_155 VRMWNQAAGAMDVYHAETTVNLLFEPIMPMKPIVLPGVG-----------
TH_4447|M.thermoresistible__bu VRMWNQAAGAMDVYQAETAMNILFEPIMPMKPIVIPGVG-----------
MLBr_01828|M.leprae_Br4923 VRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASSDQPSPT
MUL_3127|M.ulcerans_Agy99 VRMWVQAATTMGVYDAISAVALGSAPHNSPAPVILKDREMGPAGSAGS--
MAB_2230c|M.abscessus_ATCC_199 IRMWIQAATTMGVYQGVSTAAVTSVAPTPPAPTIMAPGGEMSRMSADMSG
MAV_2928|M.avium_104 MEMWAQDAAAMYGYAAASQTASTLSPFAAPPNTTAPEGES----------
:.** : * .* * :
Mb3903|M.bovis_AF2122/97 --------------------------------------------------
Rv3873|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5448|M.marinum_M --------------------------------------------------
Mvan_0077|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0768|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0064|M.smegmatis_MC2_155 --------------------------------------------------
TH_4447|M.thermoresistible__bu --------------------------------------------------
MLBr_01828|M.leprae_Br4923 APSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGMFSGFDP
MUL_3127|M.ulcerans_Agy99 --------------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 MAAQAQAAESGMALD-----------------------------------
MAV_2928|M.avium_104 --------------------------------------------------
Mb3903|M.bovis_AF2122/97 -----------------QST--------------------------TNPI
Rv3873|M.tuberculosis_H37Rv -----------------QST--------------------------TNPI
MMAR_5448|M.marinum_M -----------------QSMPT-----------------------SSTPL
Mvan_0077|M.vanbaalenii_PYR-1 -----------------QAAMATAIGSAAPGIASAAARNATFTKVSVVGK
Mflv_0768|M.gilvum_PYR-GCK -----------------EAAFAGAMSGAVPGAGEAVMRNAIISKVSSTAK
MSMEG_0064|M.smegmatis_MC2_155 -----------------ETTAAAALAQTAPRVAEGVMRNAVIEGVSAIAT
TH_4447|M.thermoresistible__bu -----------------EAAVAGALGKAAAMAPAAAARDLVFAKVSAQAT
MLBr_01828|M.leprae_Br4923 WLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIGADLAAAFA
MUL_3127|M.ulcerans_Agy99 -----------------TAALGGAEVIGSIWSWIVGMLVWVWQGILEVAY
MAB_2230c|M.abscessus_ATCC_199 -----------------DSESFFDKLMRQIQEFFSDPLGTLQKILQDFMR
MAV_2928|M.avium_104 -----------------DQAAAVSQAMAQPAGSTAQTAANTSSQLATPQA
Mb3903|M.bovis_AF2122/97 FGMPSPGSSTPVGQLPPAATQTLGQLGEMSG-------------------
Rv3873|M.tuberculosis_H37Rv FGMPSPGSSTPVGQLPPAATQTLGQLGEMSG-------------------
MMAR_5448|M.marinum_M LDMASQVTGIPSSELQQTATQ----VAEASG-------------------
Mvan_0077|M.vanbaalenii_PYR-1 LDEVNQKAGHAEGLLQQAADSGRSQAEQGQL--LQQAP-------QQGMQ
Mflv_0768|M.gilvum_PYR-GCK LDTANQIAGRAEGTLRGVVDRAGSHAEKSQG--LEQAP-------QQGMQ
MSMEG_0064|M.smegmatis_MC2_155 IESVGLAAGHAAAQANFAEQRGQGAAQKGEN-AGQEAGRESGKNMQQGMQ
TH_4447|M.thermoresistible__bu VESAALQAGRAVAQGNMAAQRAEGTVQKTENLAHQSATRSEPQQLQQGVQ
MLBr_01828|M.leprae_Br4923 SGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPMILPLLTA
MUL_3127|M.ulcerans_Agy99 LG--VTVAFLFWEFFIPLLLSLLQGLLGLIGGLLSAIGGFLADWVPFLLG
MAB_2230c|M.abscessus_ATCC_199 NPLEALVAWGPLLFFIAYEAFFIPFGFTFWGVMLSAPLWLPLLLVGLAQL
MAV_2928|M.avium_104 LSAGTSQAATQASSSSASQTGPFTWLTSALQNLQQSG-------------
Mb3903|M.bovis_AF2122/97 --------------------------PMQQLTQPLQQVTSLFSQVGGTGG
Rv3873|M.tuberculosis_H37Rv --------------------------PMQQLTQPLQQVTSLFSQVGGTGG
MMAR_5448|M.marinum_M --------------------------PMQQLAQPAQQMTSAFSNTGSSGN
Mvan_0077|M.vanbaalenii_PYR-1 MGMQMASQLGSTLGQLPQQMMQGVTQPFQQLTQPLQQMSSLFGQMGGLGG
Mflv_0768|M.gilvum_PYR-GCK MGMQMASQLGSTLGQMPQQMMQGVTQPFQQLTQPLQQMSSLFGGM--MNG
MSMEG_0064|M.smegmatis_MC2_155 MVMQMGSQA----AQAPAQLASMFQSGVQTMTQPLQQATQMVSQFASMGG
TH_4447|M.thermoresistible__bu MGMQMGSQLGSTLAQLPQQAGQMISQPMQQLTAPLQQVSSVFGQMGGMGS
MLBr_01828|M.leprae_Br4923 PLAVATAGAAGSFAGLSELAGLVGVAPPGLPSAPPVAAVAPVVPPSMPTL
MUL_3127|M.ulcerans_Agy99 AVVALLWNYP-------------------LATLLLVLGSSALVPLGLGAA
MAB_2230c|M.abscessus_ATCC_199 VNPVPVEADAPADEPAPQQARVERSSPQQQPFAMGGMPGGGGAPATPANA
MAV_2928|M.avium_104 ---------------LPTPTNNYLGLSPTFYTVMLKQTSGLGYFSNGITA
Mb3903|M.bovis_AF2122/97 GNPADEEAAQMGLLGTSPLSN---------HPLAGGSGPSAGAGLLRAES
Rv3873|M.tuberculosis_H37Rv GNPADEEAAQMGLLGTSPLSN---------HPLAGGSGPSAGAGLLRAES
MMAR_5448|M.marinum_M G--ADEEGFRMGLLGAGALSN---------HPLAGGSGPTTGAGLLRGES
Mvan_0077|M.vanbaalenii_PYR-1 D----R-GAQIGMLGATPFSN---------HPAIGGSGAATGAGLVRAAS
Mflv_0768|M.gilvum_PYR-GCK D----K-GAQIGMVGATPFSN---------HPAIGGTGPATGSGLVRAAS
MSMEG_0064|M.smegmatis_MC2_155 S----ERAMQVGLMGASPFSN---------HPMLGGSGPSTGAGLVRAMS
TH_4447|M.thermoresistible__bu G----D-SAQIGLIGASPFSN---------HPLAGGSGPATGAGLVRAAS
MLBr_01828|M.leprae_Br4923 ASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPSVTGAGVESFGYLVGRLP
MUL_3127|M.ulcerans_Agy99 ATITLPVALPLGIGGYVNYRE-------QSAPDFSGAESDTGTDRITSHP
MAB_2230c|M.abscessus_ATCC_199 PATPANAPASPAAAAATPAYMVYAVQEDPPAARFGPTLNEGSGAKAPAAG
MAV_2928|M.avium_104 FWSQLAQQLVSGPGGSTAGAG----GAWYPTPQFASLGLGNLGSVGGASH
. .
Mb3903|M.bovis_AF2122/97 LPGAGGSLTRTPLMSQLIEKPVAPSVMPAAAAGSS---------------
Rv3873|M.tuberculosis_H37Rv LPGAGGSLTRTPLMSQLIEKPVAPSVMPAAAAGSS---------------
MMAR_5448|M.marinum_M LPGAGGTLTRTPLISELVEKPMGPSVQPAAAAGSS---------------
Mvan_0077|M.vanbaalenii_PYR-1 LPGAGGTAARTPLMSNLVGSGLQPTVSAVAVGAGAG--------------
Mflv_0768|M.gilvum_PYR-GCK LPGAGGSAPQTPLMSNLVGSGLQPT-SPVAVGAGAG--------------
MSMEG_0064|M.smegmatis_MC2_155 LPGAGGTAPRTPLLSNLLG-ISG-EMKAAPAGAGS---------------
TH_4447|M.thermoresistible__bu LPGLGGTSPTTSLISNLLG-HQNPTAAPAPTGAVA---------------
MLBr_01828|M.leprae_Br4923 STARGVVGTSVRQQSSAPDRIEAPDAAATPQEQARSRWRRRAKVTPFDSS
MUL_3127|M.ulcerans_Agy99 LDSD----SATTDDSVDANPVEMMAPRHIPAEVAQP--------------
MAB_2230c|M.abscessus_ATCC_199 ISAAAAAAASARSRARRKRGARIKDPAPQFMDMNSP-------VDPDFSE
MAV_2928|M.avium_104 VSAISAGAGRAGALSVPQQWATLTSAVSPAVSEEGS--------------
. . :
Mb3903|M.bovis_AF2122/97 -------------ATGGAAPVGAG-AMGQG------AQS--GGSTRPGLV
Rv3873|M.tuberculosis_H37Rv -------------ATGGAAPVGAG-AMGQG------AQS--GGSTRPGLV
MMAR_5448|M.marinum_M -------------ASSGAAPVGAG-GMGAG------AGAGAGGSSRPGMA
Mvan_0077|M.vanbaalenii_PYR-1 -----------AGAGAGLAPVGAGSGMGGGGPMGMLGQRGKSGGNKPGLN
Mflv_0768|M.gilvum_PYR-GCK -----------PGAGVGLAPVGTGGGMGAGGPMGMFGQRGKSGGNKPGLN
MSMEG_0064|M.smegmatis_MC2_155 -----------AAAG-GLAPVGAGAGGGAGAPVAHAGQNSKSGGKKDGLV
TH_4447|M.thermoresistible__bu -----------GGAGTGPAPIG---GGGMGAPMAAMGQNQKSGGSKSGLK
MLBr_01828|M.leprae_Br4923 GSPNPKAAPTASDQGAGTLGLAGTARQASSGPATG--LVTLSNGTFSDSP
MUL_3127|M.ulcerans_Agy99 -----------SREVATVAGFADTAGSPATASARG--WSTST------AS
MAB_2230c|M.abscessus_ATCC_199 PATRHTAGVGASGRGAGQLGFAGTLPRTTSTTSAAGLIEREAASEMDGTR
MAV_2928|M.avium_104 ----------AVQAAAGGAPGGAANGLLRGMPVGALGRRGAAAGYVNKYG
.
Mb3903|M.bovis_AF2122/97 APAPLAQEREEDDEDDWDEEDDW----------------
Rv3873|M.tuberculosis_H37Rv APAPLAQEREEDDEDDWDEEDDW----------------
MMAR_5448|M.marinum_M APATLTQERDEADEDDWDDEDDW----------------
Mvan_0077|M.vanbaalenii_PYR-1 APAPLEHDLSEDDDDDW----------------------
Mflv_0768|M.gilvum_PYR-GCK APAPLDHDLGEDEDEEW----------------------
MSMEG_0064|M.smegmatis_MC2_155 APTPLTYDLSEDEDDEW----------------------
TH_4447|M.thermoresistible__bu APAPLVQDLSEDEGDDW----------------------
MLBr_01828|M.leprae_Br4923 RAPMLPRTWGADPTFCYNAADIGPAGGWDDE--------
MUL_3127|M.ulcerans_Agy99 GIPMVPSTWATSAVGAGQQ--------------------
MAB_2230c|M.abscessus_ATCC_199 TVPMLPTSWGTDPEPDPDRAPSVPAPDEDWPPGERGAST
MAV_2928|M.avium_104 FRYSVLTRPPSAG--------------------------
: