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MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQAVELTARLNSLGEAWTGGGSDKALAAATP MVVWLQTASTQAKTRAMQATAQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYF IRMWNQAALAMEVYQAETAVNTLFEKLEPMASILDPGASQSTTNPIFGMPSPGSSTPVGQLPPAATQTLG QLGEMSGPMQQLTQPLQQVTSLFSQVGGTGGGNPADEEAAQMGLLGTSPLSNHPLAGGSGPSAGAGLLRA ESLPGAGGSLTRTPLMSQLIEKPVAPSVMPAAAAGSSATGGAAPVGAGAMGQGAQSGGSTRPGLVAPAPL AQEREEDDEDDWDEEDDW
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3903 | PPE68 | - | 100% (368) | PPE family protein |
| M. bovis AF2122 / 97 | Mb3047c | PPE47 | 3e-40 | 34.67% (375) | PPE family protein |
| M. bovis AF2122 / 97 | Mb3043c | PPE46 | 4e-39 | 33.68% (383) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0768 | - | 2e-82 | 42.49% (433) | PPE protein |
| M. tuberculosis H37Rv | Rv3873 | PPE68 | 0.0 | 100.00% (368) | PPE family protein |
| M. leprae Br4923 | MLBr_00051 | - | 3e-51 | 44.86% (292) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2230c | - | 1e-39 | 31.79% (431) | PPE family protein |
| M. marinum M | MMAR_5448 | - | 1e-154 | 73.73% (373) | PPE family protein |
| M. avium 104 | MAV_0118 | - | 5e-39 | 50.96% (157) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0064 | - | 1e-94 | 45.35% (441) | PPE family protein |
| M. thermoresistible (build 8) | TH_4447 | - | 1e-93 | 45.31% (437) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1154 | - | 8e-37 | 49.72% (179) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0077 | - | 2e-91 | 44.50% (436) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3903|M.bovis_AF2122/97 ---------MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQ
Rv3873|M.tuberculosis_H37Rv ---------MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQ
MMAR_5448|M.marinum_M ---------MLWHAMPPELNTARLMAGAGPAPMLAAAAGWEALAAALDAQ
Mflv_0768|M.gilvum_PYR-GCK MANIGIPVPPSWVAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
Mvan_0077|M.vanbaalenii_PYR-1 MATIGIPIPPIWGAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
TH_4447|M.thermoresistible__bu ---------MFWHAMPPEVNTSRLMAGAGTAPMLQAAAGWEAFAISLETQ
MSMEG_0064|M.smegmatis_MC2_155 ----------MWIALPPEINTARLMVGAGPAPMLQAAAGWEGLAVLLETQ
MLBr_00051|M.leprae_Br4923 --------------------MTWPMLWPASVPSECPPNYWHTPAPSAKCE
MAB_2230c|M.abscessus_ATCC_199 ------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSVQYTTA
MUL_1154|M.ulcerans_Agy99 ------MTAPLWMASAPEAHSALLSAGPGPGSLLAAAQTWTELSAEYLAV
MAV_0118|M.avium_104 ------MTAPVWMALPPEVHSTLLSSGPGPGPLLAAAATWTGLSTQYDSA
: ... . .. * :
Mb3903|M.bovis_AF2122/97 AVELTARLN-SLGEAWTGGGSDKALAAATPMVVWLQTASTQAKTRAMQAT
Rv3873|M.tuberculosis_H37Rv AVELTARLN-SLGEAWTGGGSDKALAAATPMVVWLQTASTQAKTRAMQAT
MMAR_5448|M.marinum_M AVELTARLN-SLGEAWTGGGSEKALAAALPMVTWLQTASTQAKTRGLQAG
Mflv_0768|M.gilvum_PYR-GCK ADELASSLA-SLSQNWQGMASERAVTAAMPMVLWLRMLSLQAHKRALQAS
Mvan_0077|M.vanbaalenii_PYR-1 ADELAASLA-TLSQMWQGTASERAVMATMPMVMWLRMLSLQAQKRAAQAS
TH_4447|M.thermoresistible__bu ADELAGSLA-ALAGAWTGGASERAIAAITPMIVWLRTVSAQAHKRSAQAL
MSMEG_0064|M.smegmatis_MC2_155 AAELAAALT-NLTSVWTGAASERAVAATMPMITWLQTTAAQAQKRALQAS
MLBr_00051|M.leprae_Br4923 PEQAAVAP----------------IAAAKPMITWLQSAAEQTTT------
MAB_2230c|M.abscessus_ATCC_199 ATELTQLLAATGSGSWQGPSAAQYVASHAPYLAWLTQQSAMSATNAVLHE
MUL_1154|M.ulcerans_Agy99 AEELTAILTGVQAGAWDGPSAQCCIAAYLPYLSWLMQASADSAATAAAHQ
MAV_0118|M.avium_104 ATELTAVLTGSMP-VWDGPTADRYVAAHMPYLAWLQLAGALSAEAAAQHQ
. : : : : * : ** . :
Mb3903|M.bovis_AF2122/97 AQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYF
Rv3873|M.tuberculosis_H37Rv AQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYF
MMAR_5448|M.marinum_M AQAAAYMQAMATTPSLPEIFANHITNVILNATNFFGINTVPIAFNEMDYF
Mflv_0768|M.gilvum_PYR-GCK AQASSWTVAATGTPQLPEIELNHVTNATLHATNFLGVNGIPIALNEADY-
Mvan_0077|M.vanbaalenii_PYR-1 AQATAWASAATSTPQLPEIETNHITNAVLNATNFLGVNTVPIAVNEADY-
TH_4447|M.thermoresistible__bu AQAAAYSTAMATTPPLAEIEQNHITRAVLHATNFLGINTVPIGINEMDYF
MSMEG_0064|M.smegmatis_MC2_155 AQASSYSLALATTPPLPEIEQNHITHGVLEATNFLGINTVPIALNEMDYF
MLBr_00051|M.leprae_Br4923 -QAEAHRQAMASTPGMAVITENHITQAILATINFFGINMAPIAFTEAGDF
MAB_2230c|M.abscessus_ATCC_199 TSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNEADY-
MUL_1154|M.ulcerans_Agy99 AAATAYTGALAAMPTLGELAANHATHAVLVATNFFGLNTIPIALNEVDY-
MAV_0118|M.avium_104 GVATAYTAALAAMPTLPELAANHATHAALVATNFFGVNTIPIAVNEADY-
* : * : * : : ** . * : **:*:* **...* .
Mb3903|M.bovis_AF2122/97 IRMWNQAALAMEVYQAETAVNTLFEKLEPMA-----------------SI
Rv3873|M.tuberculosis_H37Rv IRMWNQAALAMEVYQAETAVNTLFEKLEPMA-----------------SI
MMAR_5448|M.marinum_M VRMWNQAALAMDVYQAETTANTLFEQLEPMT-----------------SI
Mflv_0768|M.gilvum_PYR-GCK IRMWNQAAAVMTAYETETVLNTTFEPVAPPK-----------------PI
Mvan_0077|M.vanbaalenii_PYR-1 IRMWNQAAAVMTGYETETILNSTFEPVAPPK-----------------PI
TH_4447|M.thermoresistible__bu VRMWNQAAGAMDVYQAETAMNILFEPIMPMK-----------------PI
MSMEG_0064|M.smegmatis_MC2_155 VRMWNQAAGAMDVYHAETTVNLLFEPIMPMK-----------------PI
MLBr_00051|M.leprae_Br4923 ICMRTQTALAMNSYQAETLLNTAFQKLEPMA-----------------AI
MAB_2230c|M.abscessus_ATCC_199 IRMWIQAATTMGVYQG-VSTAAVTSVAPTPP---------------APTI
MUL_1154|M.ulcerans_Agy99 VRMWIQAATTMSVYQA-VAADALLAVPRTPP---------------APVI
MAV_0118|M.avium_104 ARMWTQAATTMTTYQATTEAVQMTSVAGSGTGGKAGSGSGSGTGAGTGTG
* *:* .* *. . .
Mb3903|M.bovis_AF2122/97 LDPGASQST--------------------------TNPIFGMPSPGSS--
Rv3873|M.tuberculosis_H37Rv LDPGASQST--------------------------TNPIFGMPSPGSS--
MMAR_5448|M.marinum_M LDPATAQSMPT-----------------------SSTPLLDMASQVTG--
Mflv_0768|M.gilvum_PYR-GCK AVPPGSEAAFAGAMSGAVPGAGEAVMRNAIISKVSSTAKLDTANQIAG--
Mvan_0077|M.vanbaalenii_PYR-1 TVFGSTQAAMATAIGSAAPGIASAAARNATFTKVSVVGKLDEVNQKAG--
TH_4447|M.thermoresistible__bu VIPGVGEAAVAGALGKAAAMAPAAAARDLVFAKVSAQATVESAALQAGRA
MSMEG_0064|M.smegmatis_MC2_155 VLPGVGETTAAAALAQTAPRVAEGVMRNAVIEGVSAIATIESVGLAAG--
MLBr_00051|M.leprae_Br4923 LNPSSYSPPS------------------------ALTSQVNQFTQMIS--
MAB_2230c|M.abscessus_ATCC_199 MAPGGEMSRMSADMSGMAAQAQAAESGMALDDSESFFDKLMRQIQEFFSD
MUL_1154|M.ulcerans_Agy99 IKPG---ADAAAQFASAVVQAVAETP-------------IQRLLLELATL
MAV_0118|M.avium_104 TGTGTGTGTGTGTGTGAGSGTGGGTGAGGGGGTGSFQLPTPEEIWEMLFG
Mb3903|M.bovis_AF2122/97 --------------------------------------------------
Rv3873|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5448|M.marinum_M --------------------------------------------------
Mflv_0768|M.gilvum_PYR-GCK ---------------------------------------------RAEGT
Mvan_0077|M.vanbaalenii_PYR-1 ---------------------------------------------HAEGL
TH_4447|M.thermoresistible__bu VAQG------------------------------------NMAAQRAEGT
MSMEG_0064|M.smegmatis_MC2_155 ---------------------------------------------HAAAQ
MLBr_00051|M.leprae_Br4923 --------------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 PLGT--------------------------------LQKILQDFMRNP--
MUL_1154|M.ulcerans_Agy99 VGAE--------------------------------FINVFELIVG----
MAV_0118|M.avium_104 PDGEQIPGQGQPNWSPSEYLQNLGNFFNGNAQAVAWLQQNLSGLLNPSQF
Mb3903|M.bovis_AF2122/97 ----------------------------------TPVGQLPPAATQTLGQ
Rv3873|M.tuberculosis_H37Rv ----------------------------------TPVGQLPPAATQTLGQ
MMAR_5448|M.marinum_M ----------------------------------IPSSELQQTATQ----
Mflv_0768|M.gilvum_PYR-GCK LRGVVDRAGSHAEKSQGLEQAPQ----QGMQMGMQMASQLGSTLGQMPQQ
Mvan_0077|M.vanbaalenii_PYR-1 LQQAADSGRSQAEQGQLLQQAPQ----QGMQMGMQMASQLGSTLGQLPQQ
TH_4447|M.thermoresistible__bu VQKTENLAHQSATRSE--PQQLQ----QGVQMGMQMGSQLGSTLAQLPQQ
MSMEG_0064|M.smegmatis_MC2_155 ANFAEQRGQGAAQKGENAGQEAGRESGKNMQQGMQMVMQMGSQAAQAPAQ
MLBr_00051|M.leprae_Br4923 --------------------------------GFSAALPSTQVLQQTVGQ
MAB_2230c|M.abscessus_ATCC_199 ------LEALVAWGPLLFFIAYEAFFIPFGFTFWGVMLSAPLWLPLLLVG
MUL_1154|M.ulcerans_Agy99 ------IVVLSTYGLKLPLLALLDFLT----GHFSVALSLLWNYAMLWFG
MAV_0118|M.avium_104 PALINYFIAWQTYRIINWTIRTLRFILQELPLLLQVGLSLSITSLGGLAG
Mb3903|M.bovis_AF2122/97 LGEMSG-PMQQLTQPLQQVTSLFSQVGGTGGGNPADEEAAQMGLLGTSPL
Rv3873|M.tuberculosis_H37Rv LGEMSG-PMQQLTQPLQQVTSLFSQVGGTGGGNPADEEAAQMGLLGTSPL
MMAR_5448|M.marinum_M VAEASG-PMQQLAQPAQQMTSAFSNTGSSGNG--ADEEGFRMGLLGAGAL
Mflv_0768|M.gilvum_PYR-GCK MMQGVTQPFQQLTQPLQQMSSLFGGM--MNGD----K-GAQIGMVGATPF
Mvan_0077|M.vanbaalenii_PYR-1 MMQGVTQPFQQLTQPLQQMSSLFGQMGGLGGD----R-GAQIGMLGATPF
TH_4447|M.thermoresistible__bu AGQMISQPMQQLTAPLQQVSSVFGQMGGMGSG----D-SAQIGLIGASPF
MSMEG_0064|M.smegmatis_MC2_155 LASMFQSGVQTMTQPLQQATQMVSQFASMGGS----ERAMQVGLMGASPF
MLBr_00051|M.leprae_Br4923 VAELAR-PMQQVKSLFTSIDSTGVYTSAQRGD---TESAHRIGLFGASTL
MAB_2230c|M.abscessus_ATCC_199 LAQLV----NPVPVEADAPADEPAPQQARVERSSPQQQPFAMGGMPGGGG
MUL_1154|M.ulcerans_Agy99 FV---------VPPALQIVFDPLLVVAAVIEW------------ILGGGA
MAV_0118|M.avium_104 LAGLAGLAGLAAPASAPAPAAMPQPAGMGAQPPVVSAAPAMAPMAPTSPV
Mb3903|M.bovis_AF2122/97 SNHPLAGGSGPSAGAGLLRAESLPGAGGSLTRTPLMSQLIE---KPVAPS
Rv3873|M.tuberculosis_H37Rv SNHPLAGGSGPSAGAGLLRAESLPGAGGSLTRTPLMSQLIE---KPVAPS
MMAR_5448|M.marinum_M SNHPLAGGSGPTTGAGLLRGESLPGAGGTLTRTPLISELVE---KPMGPS
Mflv_0768|M.gilvum_PYR-GCK SNHPAIGGTGPATGSGLVRAASLPGAGGSAPQTPLMSNLVGSGLQPT-SP
Mvan_0077|M.vanbaalenii_PYR-1 SNHPAIGGSGAATGAGLVRAASLPGAGGTAARTPLMSNLVGSGLQPTVSA
TH_4447|M.thermoresistible__bu SNHPLAGGSGPATGAGLVRAASLPGLGGTSPTTSLISNLLG-HQNPTAAP
MSMEG_0064|M.smegmatis_MC2_155 SNHPMLGGSGPSTGAGLVRAMSLPGAGGTAPRTPLLSNLLG----ISGEM
MLBr_00051|M.leprae_Br4923 SSHPLVGITGTTTDTRLLCAESLPSASGSLAWTPLMTQFQL---------
MAB_2230c|M.abscessus_ATCC_199 APATPAN-APATPANAPASPAAAAATPAYMVYAVQEDPPAARFGPTLNEG
MUL_1154|M.ulcerans_Agy99 ALGSVG----ALDANLAAGLALAAVAAAPVADAAVG-------------S
MAV_0118|M.avium_104 APATSAVSTPAPVASAIAPPATPPVPPAPVTGAEGFGYMVGSFGLGMDSK
: . . . . :
Mb3903|M.bovis_AF2122/97 VMPAAAAGSSATGGAAPVGAGA----------------------------
Rv3873|M.tuberculosis_H37Rv VMPAAAAGSSATGGAAPVGAGA----------------------------
MMAR_5448|M.marinum_M VQPAAAAGSSASSGAAPVGAGG----------------------------
Mflv_0768|M.gilvum_PYR-GCK VAVGAGAGPGAGVGLAPVGTGGGMGA------------------------
Mvan_0077|M.vanbaalenii_PYR-1 VAVGAGAGAGAGAGLAPVGAGSGMGG------------------------
TH_4447|M.thermoresistible__bu APTGAVAG-GAGTGPAPIG-GGGMG-------------------------
MSMEG_0064|M.smegmatis_MC2_155 KAAPAGAGSAAAGGLAPVGAGAGGGA------------------------
MLBr_00051|M.leprae_Br4923 IDKSIAPEPRQRVMLPPWAAGS----------------------------
MAB_2230c|M.abscessus_ATCC_199 SGAKAPAAGIS----AAAAAAASARSRARRKRGARIKDPAPQFMDMNSPV
MUL_1154|M.ulcerans_Agy99 LGVLTSAAAVT----AAAAAAP----------------------------
MAV_0118|M.avium_104 AQTRARSALAAGRPAASSAGAAAVEQEQGRTRRRPRSVIDPGYRYEFIEG
. .. . .
Mb3903|M.bovis_AF2122/97 ---------------------MGQGAQS--GGSTRPGLVAPAPLAQEREE
Rv3873|M.tuberculosis_H37Rv ---------------------MGQGAQS--GGSTRPGLVAPAPLAQEREE
MMAR_5448|M.marinum_M ---------------------MGAGAGAGAGGSSRPGMAAPATLTQERDE
Mflv_0768|M.gilvum_PYR-GCK ------------------GGPMGMFGQRGKSGGNKPGLNAPAPLDHDLGE
Mvan_0077|M.vanbaalenii_PYR-1 ------------------GGPMGMLGQRGKSGGNKPGLNAPAPLEHDLSE
TH_4447|M.thermoresistible__bu -------------------APMAAMGQNQKSGGSKSGLKAPAPLVQDLSE
MSMEG_0064|M.smegmatis_MC2_155 ------------------GAPVAHAGQNSKSGGKKDGLVAPTPLTYDLSE
MLBr_00051|M.leprae_Br4923 ------------------------PGHNAQDGGTT---------------
MAB_2230c|M.abscessus_ATCC_199 DPDFSEPATRHTAGVGASGRGAGQLGFAGTLPRTTSTTSAAGLIEREAAS
MUL_1154|M.ulcerans_Agy99 ------------------GQGVGLVGFAATMPNPT-TLPAGGLVTVGGAD
MAV_0118|M.avium_104 DDEVVAVASAAQDRYRPSDSGGSIQGFAGTLPKSG--VRASGLNTLAGNE
.
Mb3903|M.bovis_AF2122/97 DDEDDWDEEDDW---------------------------------
Rv3873|M.tuberculosis_H37Rv DDEDDWDEEDDW---------------------------------
MMAR_5448|M.marinum_M ADEDDWDDEDDW---------------------------------
Mflv_0768|M.gilvum_PYR-GCK DEDEEW---------------------------------------
Mvan_0077|M.vanbaalenii_PYR-1 DDDDDW---------------------------------------
TH_4447|M.thermoresistible__bu DEGDDW---------------------------------------
MSMEG_0064|M.smegmatis_MC2_155 DEDDEW---------------------------------------
MLBr_00051|M.leprae_Br4923 ---------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 EMDGTRTVPMLPTSWGTDPEPDPDRAPSVPAPDEDWPPGERGAST
MUL_1154|M.ulcerans_Agy99 PCAGAR-VPMLPASWVALG--------------------------
MAV_0118|M.avium_104 SGDGAR-IPMLPESWDGP---------------------------