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MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTEYSSAANELTTTLGSVRAGVWDGASAEQYQT AHVPYLSWLHETSAVSAGVAAQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAARTAAQDATKPPPIVPDPNDPIEML LKNSQHFLGMYRALKGLITDPVGTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAATFAVMGTPIYAAIMGP AAGISIPLAITLASLSQMPEAPPVDAPAETVPARIDQPHAVAMGGAPAPTASTAAPTPTTTSPATPGSAP APTPPPAGAEGLGYAVRGDGPGFGFGPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDR GYRHEYATMDDHTPTGPQDPVTAVASGTGAGRLGFAGVHTATTAVEATGLSTLDGDAENRTIPMLPGTWD VTDDDR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4783 | - | - | 100% (496) | PPE family protein |
| M. abscessus ATCC 19977 | MAB_2230c | - | e-101 | 43.77% (514) | PPE family protein |
| M. abscessus ATCC 19977 | MAB_0047 | - | 1e-98 | 42.55% (510) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0294 | PPE4 | 1e-105 | 44.88% (508) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-106 | 43.82% (518) | PPE protein |
| M. tuberculosis H37Rv | Rv0286 | PPE4 | 1e-105 | 44.88% (508) | PPE family protein |
| M. leprae Br4923 | MLBr_01991 | PPE | 9e-71 | 37.45% (494) | PPE-family protein |
| M. marinum M | MMAR_0545 | - | 1e-102 | 42.50% (513) | PPE family protein, PPE4 |
| M. avium 104 | MAV_4867 | - | 1e-101 | 44.18% (498) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-109 | 45.74% (516) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 2e-84 | 52.37% (317) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1208 | - | 1e-102 | 42.30% (513) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-110 | 46.21% (515) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0294|M.bovis_AF2122/97 ----------MAAPIWMASPPEVHSALLSNGPGPGSLVAAATAWSQLSAE
Rv0286|M.tuberculosis_H37Rv ----------MAAPIWMASPPEVHSALLSNGPGPGSLVAAATAWSQLSAE
MMAR_0545|M.marinum_M -------MAVAAGPIWIASPPEVHSAMLSSGPGPASLLAAAGVWSALSAE
MUL_1208|M.ulcerans_Agy99 -------MAVAAGPIWIASPPEVHSAMLSSGPGPASLLAAAGVWSALSAE
MAV_4867|M.avium_104 -------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSLSAQ
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
MLBr_01991|M.leprae_Br4923 ----------------MAIPPEVHSVLLSAGQGAESLLVAATQWQELSKQ
:* ****** :** * *. .:..*. * ** :
Mb0294|M.bovis_AF2122/97 YASTAAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAAGAA
Rv0286|M.tuberculosis_H37Rv YASTAAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAAGAA
MMAR_0545|M.marinum_M YALTAAELSEVLAAVQAGAWQGPSGFQYVAAHLPYVAWLLQASADGAGKA
MUL_1208|M.ulcerans_Agy99 YALTAAELSEVLAAVQAGAWQGPSGFQYVAAHLPYVAWLLQASADGAGKA
MAV_4867|M.avium_104 YATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSAGAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
MLBr_01991|M.leprae_Br4923 YTYAAAELTRLLTHVQATSWRGTSATRFVAAHGAYLVWLEQTSINNAITA
*: :* **: * . . * * *. : :** .*: ** : * * *
Mb0294|M.bovis_AF2122/97 AQHEAAAAAYTTALAAMPTLAELAANHVIHTVLVATNFFGINTIPITLNE
Rv0286|M.tuberculosis_H37Rv AQHEAAAAAYTTALAAMPTLAELAANHVIHTVLVATNFFGINTIPITLNE
MMAR_0545|M.marinum_M AEHEAAAVAYSGALAAMPTLTELGANHALHGVLVATNFFGLNAIPIALNE
MUL_1208|M.ulcerans_Agy99 AEHEAAAVAYSGALAAMPTLTELGANHALHGVLVATNFFGLNAIPIALNE
MAV_4867|M.avium_104 AQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIAVNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
MLBr_01991|M.leprae_Br4923 KQHEIAAIAYSSALAAMPTLAELTANRATRGFLIATNFFGINTIPIALNE
. : ** **: ***:***: ** *:. : *:.***:*:*:***::.*
Mb0294|M.bovis_AF2122/97 ADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNPGGG-------
Rv0286|M.tuberculosis_H37Rv ADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNPGGG-------
MMAR_0545|M.marinum_M ADYVRMWVQAATTMGLYQATAGAALASAPRTGPPPKVVNPGGGQVAHLAA
MUL_1208|M.ulcerans_Agy99 ADYVRMWVQAATTMGLYQATAGAALASAPRTGPPPKVVNPGGGQVAHLAA
MAV_4867|M.avium_104 ADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPGGE-------
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVG-EAGRAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVG-EAGRAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVG-EAGSAS
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVS-EAADAM
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSG-------
MLBr_01991|M.leprae_Br4923 ADYVRMWVQAADTMATYQAISEAVTATILPTQVAPPILAPGSA-------
*** ***:*** *. **: : : : : .* :: *.
Mb0294|M.bovis_AF2122/97 -------AASTVGAVNPWQWLLALLQQLWNAYTGFYGWMLQLIWQFLQDP
Rv0286|M.tuberculosis_H37Rv -------AASTVGAVNPWQWLLALLQQLWNAYTGFYGWMLQLIWQFLQDP
MMAR_0545|M.marinum_M DAAQAQSGAAAAGGSDPWQLLWQLLQYLWNAYTGFNTWMFDLIWEFLQDP
MUL_1208|M.ulcerans_Agy99 DAARAQSGAAAAGGSDPWQLLWQLLQYLWNAYTGFNTWMFDLIWEFLQDP
MAV_4867|M.avium_104 ----ANNLAANAAQNSSGDWWQNFIQQLS---------------QFFQN-
Mflv_0325|M.gilvum_PYR-GCK ADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDP
Mvan_0415|M.vanbaalenii_PYR-1 ADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDP
MSMEG_0619|M.smegmatis_MC2_155 ASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDP
TH_3569|M.thermoresistible__bu ATTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDP
MAB_4783|M.abscessus_ATCC_1997 -AAARTAAQDATKPPPIVPDPNDPIEMLLKNSQHFLG-MYRALKGLITDP
MLBr_01991|M.leprae_Br4923 -------------TQNVLQSVPDWIVQLLTD-----------ILDFIADP
: : :: :
Mb0294|M.bovis_AF2122/97 IGNSIKIIIAFLTNPIQALITYGPLLFALGYQIFFNLVGWPTWGMILSSP
Rv0286|M.tuberculosis_H37Rv IGNSIKIIIAFLTNPIQALITYGPLLFALGYQIFFNLVGWPTWGMILSSP
MMAR_0545|M.marinum_M IGNTIKIIIAFLTNPLQAIITYGPLLFALSYQIFFNLVGWPTWALILSSP
MUL_1208|M.ulcerans_Agy99 IGNTIKIIIAFLTNPLQAIITYGPLLFALSYQIFFNLVGWPTWALILSSP
MAV_4867|M.avium_104 ---IQKMLQDFWANLPAFLAANGPLLFFVAYQVFFNAVGWPTWGAILTAP
Mflv_0325|M.gilvum_PYR-GCK IGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLP
Mvan_0415|M.vanbaalenii_PYR-1 LGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLP
MSMEG_0619|M.smegmatis_MC2_155 LGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASP
TH_3569|M.thermoresistible__bu IGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASP
MAB_4783|M.abscessus_ATCC_1997 VGTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAATFAVMGTPIYAAIMGPA
MLBr_01991|M.leprae_Br4923 YKYFLRFFQRLGFRPAIAVVLA---IIALQLYDFLWYPYYASYGMLLLP-
:: : . : : . : ::
Mb0294|M.bovis_AF2122/97 FLLPAGLGLGLAAIAFLPIVLAP--AVIPPASTPLAAAAVAAGSVWPAVS
Rv0286|M.tuberculosis_H37Rv FLLPAGLGLGLAAIAFLPIVLAP--AVIPPASTPLAAAAVAAGSVWPAVS
MMAR_0545|M.marinum_M FLLPAALGLALSAIAFTPIQIA---AEVPAAAAPLAAAAVTAKSVFPAAS
MUL_1208|M.ulcerans_Agy99 FLLPAALGLALSAIAFTPIQIA---AEVPAAAAPLAAAAVTAKSVFPAAS
MAV_4867|M.avium_104 FLLPLLLGIGLSSLLAAPAEIAP--VAAPAAITPVLASNKPP-TLPAAVA
Mflv_0325|M.gilvum_PYR-GCK LLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPA
Mvan_0415|M.vanbaalenii_PYR-1 LVATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAI
MSMEG_0619|M.smegmatis_MC2_155 FLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAV
TH_3569|M.thermoresistible__bu VLIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP--------
MAB_4783|M.abscessus_ATCC_1997 AGISIPLAITLASLSQMPEAPP---VDAPAETVP--ARIDQPHAVAMGGA
MLBr_01991|M.leprae_Br4923 FFAPALSVLGTLSVLWNGQLSAG-----LPPNPAGSHPDNNAGPRIHVGV
. : . . .
Mb0294|M.bovis_AF2122/97 MAVTGAGTAGAATPAAGAAPSAGAAPAPAAPATASFAYAVGGSGDWGPSL
Rv0286|M.tuberculosis_H37Rv MAVTGAGTAGAATPAAGAAPSAGAAPAPAAPATASFAYAVGGSGDWGPSL
MMAR_0545|M.marinum_M LASPGTGSAGAPASGAGAGAPGSAPPGPAAPAPASFLYAVGGSGDWGPSL
MUL_1208|M.ulcerans_Agy99 LASPGTGSAGAPASGAGAGAPGTAPPGPGAPAPASFLYAVGGSGDWGPSL
MAV_4867|M.avium_104 LAPSVATPAGAPASTVAAGSGAAAAPGP-AAAAGNFAYLVAFGGDPDTGV
Mflv_0325|M.gilvum_PYR-GCK TMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDPYEGF
Mvan_0415|M.vanbaalenii_PYR-1 AVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDPGTGF
MSMEG_0619|M.smegmatis_MC2_155 GISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDPGEGF
TH_3569|M.thermoresistible__bu -----------VRAEPQNPLPLTXXX------------------------
MAB_4783|M.abscessus_ATCC_1997 PAPTASTAAPTPTTTSPATPGSAPAPTPPPAGAEGLGYAVRGDG-PGFGF
MLBr_01991|M.leprae_Br4923 APPASATSSGNSYTSNSAPSTSASATTDNPLSSPSIRYAIPGLSPPEVSS
.
Mb0294|M.bovis_AF2122/97 GPTVGGRGGIKAPAATVPAAAAAAATRGQSRARRRRRS----ELRDYGDE
Rv0286|M.tuberculosis_H37Rv GPTVGGRGGIKAPAATVPAAAAAAATRGQSRARRRRRS----ELRDYGDE
MMAR_0545|M.marinum_M GPTVGGRSGAKAPAATIPAAGAAAASRASARSRRRRRT----EMRDYGDE
MUL_1208|M.ulcerans_Agy99 GPTVGGRSGAKAPAVTIPAAGAAAASRASARSRRRRRT----EMRDYGDE
MAV_4867|M.avium_104 GPTLSGRGGAKAPAATIPAAGAAAPARAEARARRRRRA----ALHDYSDE
Mflv_0325|M.gilvum_PYR-GCK SPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADA
Mvan_0415|M.vanbaalenii_PYR-1 SPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADA
MSMEG_0619|M.smegmatis_MC2_155 TPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADA
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 GPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRGYRHE
MLBr_01991|M.leprae_Br4923 GPKAGTKSPDTATN-TIGITAAARTNSPSARAHRKRGNKTRGGARGYRYE
Mb0294|M.bovis_AF2122/97 FLDMDS----DSGFGPSTGDHGAQASERGAGTLGFAGTATKERRVRAVGL
Rv0286|M.tuberculosis_H37Rv FLDMDS----DSGFGPSTGDHGAQASERGAGTLGFAGTATKERRVRAVGL
MMAR_0545|M.marinum_M FLDMDA----NGVTGPAATDDAARASERGAGQFGFAGTVSTEAVLQAAGL
MUL_1208|M.ulcerans_Agy99 FLDMDA----NGVTGPAATDDAARASERGAGQFGFAGTVSTEAVLQAAGL
MAV_4867|M.avium_104 FLDMDSGFGVPPDYGAEEELAAAVASGQGAGTLGFAGTQQRRKAFQAAGL
Mflv_0325|M.gilvum_PYR-GCK YADYEEL---PDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGD-EQAGGL
Mvan_0415|M.vanbaalenii_PYR-1 YADYEPE---PDDEPPVRQEPRIAATERGAGPMGFAGTVSRDA-AQAGGL
MSMEG_0619|M.smegmatis_MC2_155 YMDYEE----PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHD-VTAAGL
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 YATMDD-----HTPTGPQDPVTAVASGTGAGRLGFAGVHTATTAVEATGL
MLBr_01991|M.leprae_Br4923 FVEGTATMADTVDAPDHSEPTSHTISNHSAGPIGFAGTVPTTA-------
Mb0294|M.bovis_AF2122/97 TALAGDEFGNGPRMPMVPGTWEQGSNEPEAPDGSGRGGGDGLPHDSK-
Rv0286|M.tuberculosis_H37Rv TALAGDEFGNGPRMPMVPGTWEQGSNEPEAPDGSGRGGGDGLPHDSK-
MMAR_0545|M.marinum_M TELAVDEFGNGPRMPMVPGSWDS----PQE------GREDGLQSE---
MUL_1208|M.ulcerans_Agy99 TELAVDEFGNGPRMPMVPGSWDS----PQE------GREDGLQSE---
MAV_4867|M.avium_104 TKLADDDFGGSPRMPMVPGTWEQD---TQN------GAHPTEPGKGG-
Mflv_0325|M.gilvum_PYR-GCK TTLAGDSFGGGPREPMLPGTWDPD--ATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 TTLPGDPFGGGPKAPMLPGTWDPD--TEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 TTLTGDTFDDRPVTPMLPGTWDGD--ENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu ------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 STLDGD--AENRTIPMLPGTWDVT--------------DDDR------
MLBr_01991|M.leprae_Br4923 STPTGMAASTSSSVPLLPTTWITG-------------TSETAVHE---