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ANIGIPVPPSWVAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQADELASSLASLSQNWQGMASE RAVTAAMPMVLWLRMLSLQAHKRALQASAQASSWTVAATGTPQLPEIELNHVTNATLHATNFLGVNGIPI ALNEADYIRMWNQAAAVMTAYETETVLNTTFEPVAPPKPIAVPPGSEAAFAGAMSGAVPGAGEAVMRNAI ISKVSSTAKLDTANQIAGRAEGTLRGVVDRAGSHAEKSQGLEQAPQQGMQMGMQMASQLGSTLGQMPQQM MQGVTQPFQQLTQPLQQMSSLFGGMMNGDKGAQIGMVGATPFSNHPAIGGTGPATGSGLVRAASLPGAGG SAPQTPLMSNLVGSGLQPTSPVAVGAGAGPGAGVGLAPVGTGGGMGAGGPMGMFGQRGKSGGNKPGLNAP APLDHDLGEDEDEEW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0768 | - | - | 100% (436) | PPE protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 4e-35 | 38.78% (196) | PPE protein |
| M. gilvum PYR-GCK | Mflv_0757 | - | 6e-10 | 24.94% (429) | hypothetical protein Mflv_0757 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3903 | PPE68 | 4e-82 | 42.25% (426) | PPE family protein |
| M. tuberculosis H37Rv | Rv3873 | PPE68 | 4e-82 | 42.25% (426) | PPE family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 3e-27 | 35.23% (176) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2230c | - | 1e-34 | 38.79% (214) | PPE family protein |
| M. marinum M | MMAR_5448 | - | 1e-81 | 42.36% (432) | PPE family protein |
| M. avium 104 | MAV_4872 | - | 6e-38 | 30.95% (433) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0064 | - | 1e-125 | 53.69% (434) | PPE family protein |
| M. thermoresistible (build 8) | TH_4447 | - | 1e-134 | 57.95% (440) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1202 | - | 2e-36 | 28.57% (427) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0077 | - | 0.0 | 78.36% (439) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3903|M.bovis_AF2122/97 ---------MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQ
Rv3873|M.tuberculosis_H37Rv ---------MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQ
MMAR_5448|M.marinum_M ---------MLWHAMPPELNTARLMAGAGPAPMLAAAAGWEALAAALDAQ
Mflv_0768|M.gilvum_PYR-GCK MANIGIPVPPSWVAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
Mvan_0077|M.vanbaalenii_PYR-1 MATIGIPIPPIWGAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
TH_4447|M.thermoresistible__bu ---------MFWHAMPPEVNTSRLMAGAGTAPMLQAAAGWEAFAISLETQ
MSMEG_0064|M.smegmatis_MC2_155 ----------MWIALPPEINTARLMVGAGPAPMLQAAAGWEGLAVLLETQ
MAV_4872|M.avium_104 ------MTAPVWMAFAPEVHSTLLSSGPGPAGLLSAAASWTSLSETYASA
MUL_1202|M.ulcerans_Agy99 ----------MWFTSPPEVHSALLSSGPGPASLLSGAAAWAGLSTEYASV
MLBr_01828|M.leprae_Br4923 ------MSAPIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSLSSVYAEM
MAB_2230c|M.abscessus_ATCC_199 ------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSVQYTTA
* : .**:::: * *.*. :* .* * ::
Mb3903|M.bovis_AF2122/97 AVELTARLNSLG-EAWTGGGSDKALAAATPMVVWLQTASTQAKTRAMQAT
Rv3873|M.tuberculosis_H37Rv AVELTARLNSLG-EAWTGGGSDKALAAATPMVVWLQTASTQAKTRAMQAT
MMAR_5448|M.marinum_M AVELTARLNSLG-EAWTGGGSEKALAAALPMVTWLQTASTQAKTRGLQAG
Mflv_0768|M.gilvum_PYR-GCK ADELASSLASLS-QNWQGMASERAVTAAMPMVLWLRMLSLQAHKRALQAS
Mvan_0077|M.vanbaalenii_PYR-1 ADELAASLATLS-QMWQGTASERAVMATMPMVMWLRMLSLQAQKRAAQAS
TH_4447|M.thermoresistible__bu ADELAGSLAALA-GAWTGGASERAIAAITPMIVWLRTVSAQAHKRSAQAL
MSMEG_0064|M.smegmatis_MC2_155 AAELAAALTNLT-SVWTGAASERAVAATMPMITWLQTTAAQAQKRALQAS
MAV_4872|M.avium_104 AAELSATLAAAQSDAWQGPSAERYVAAHAPYLAWLERASANSAAVAAQQE
MUL_1202|M.ulcerans_Agy99 ADELMGVLAAVQGGAWEGLSAELYVAAHVPYLMWLMRASATSAQAAAQHE
MLBr_01828|M.leprae_Br4923 ADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSAVMAAHYE
MAB_2230c|M.abscessus_ATCC_199 ATELTQLLAATGSGSWQGPSAAQYVASHAPYLAWLTQQSAMSATNAVLHE
* ** * * * .: : : * : ** : : .
Mb3903|M.bovis_AF2122/97 AQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYF
Rv3873|M.tuberculosis_H37Rv AQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYF
MMAR_5448|M.marinum_M AQAAAYMQAMATTPSLPEIFANHITNVILNATNFFGINTVPIAFNEMDYF
Mflv_0768|M.gilvum_PYR-GCK AQASSWTVAATGTPQLPEIELNHVTNATLHATNFLGVNGIPIALNEADY-
Mvan_0077|M.vanbaalenii_PYR-1 AQATAWASAATSTPQLPEIETNHITNAVLNATNFLGVNTVPIAVNEADY-
TH_4447|M.thermoresistible__bu AQAAAYSTAMATTPPLAEIEQNHITRAVLHATNFLGINTVPIGINEMDYF
MSMEG_0064|M.smegmatis_MC2_155 AQASSYSLALATTPPLPEIEQNHITHGVLEATNFLGINTVPIALNEMDYF
MAV_4872|M.avium_104 TAAAAYTAALAAMPTLPELAGNHATHAALVATNFFGVNTIPIAVNEADY-
MUL_1202|M.ulcerans_Agy99 AAAAAYTTALAAMPTMPELAANHVIHGVLMATNFFGINTIPIAANEADY-
MLBr_01828|M.leprae_Br4923 TMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIARNEIDY-
MAB_2230c|M.abscessus_ATCC_199 TSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNEADY-
: *::: : : * :.*: *: . * :***:*:* :**. .* **
Mb3903|M.bovis_AF2122/97 IRMWNQAALAMEVYQAETAVNTLFEKLEPMASILDPGASQST--------
Rv3873|M.tuberculosis_H37Rv IRMWNQAALAMEVYQAETAVNTLFEKLEPMASILDPGASQST--------
MMAR_5448|M.marinum_M VRMWNQAALAMDVYQAETTANTLFEQLEPMTSILDPATAQSMPT------
Mflv_0768|M.gilvum_PYR-GCK IRMWNQAAAVMTAYETETVLNTTFEPVAPPKPIAVPPGSEAAFAGAMS--
Mvan_0077|M.vanbaalenii_PYR-1 IRMWNQAAAVMTGYETETILNSTFEPVAPPKPITVFGSTQAAMATAIG--
TH_4447|M.thermoresistible__bu VRMWNQAAGAMDVYQAETAMNILFEPIMPMKPIVIPGVGEAAVAGALG--
MSMEG_0064|M.smegmatis_MC2_155 VRMWNQAAGAMDVYHAETTVNLLFEPIMPMKPIVLPGVGETTAAAALA--
MAV_4872|M.avium_104 ARMWVQAATTMSTYQAVAGTAVAAAPQTDPAPPIVNSTSSDGSDSDDS--
MUL_1202|M.ulcerans_Agy99 VRMWIQAATTMSTYQAVSAAAVASTPPSTPAPRILAAPAAAHDHDHDH--
MLBr_01828|M.leprae_Br4923 VRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASSDQPSPT
MAB_2230c|M.abscessus_ATCC_199 IRMWIQAATTMGVYQGVSTAAVTSVAPTPPAPTIMAPGGEMSRMSADM--
*** :** .* *. : .
Mb3903|M.bovis_AF2122/97 --------------------------------------------------
Rv3873|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5448|M.marinum_M --------------------------------------------------
Mflv_0768|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0077|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4447|M.thermoresistible__bu --------------------------------------------------
MSMEG_0064|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4872|M.avium_104 GDD-----------------------------GGIVDN------------
MUL_1202|M.ulcerans_Agy99 GGDPTPIDYFVAEVLRIISGGRIIWDPAEGTVNGIPYD------------
MLBr_01828|M.leprae_Br4923 APSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGMFSGFDP
MAB_2230c|M.abscessus_ATCC_199 --------------------------------SGMAAQ------------
Mb3903|M.bovis_AF2122/97 --------------------TNPIFGMPSPGSSTPVG-------------
Rv3873|M.tuberculosis_H37Rv --------------------TNPIFGMPSPGSSTPVG-------------
MMAR_5448|M.marinum_M -------------------SSTPLLDMASQVTGIPSS-------------
Mflv_0768|M.gilvum_PYR-GCK ---------GAVPGAGEAVMRNAIISKVSSTAKLDTANQIAG--------
Mvan_0077|M.vanbaalenii_PYR-1 ---------SAAPGIASAAARNATFTKVSVVGKLDEVNQKAG--------
TH_4447|M.thermoresistible__bu ---------KAAAMAPAAAARDLVFAKVSAQATVESAALQAGR-------
MSMEG_0064|M.smegmatis_MC2_155 ---------QTAPRVAEGVMRNAVIEGVSAIATIESVGLAAG--------
MAV_4872|M.avium_104 ---------DGGNPYQLSWWVNRFLEIFQTIGRDLEEFPEN--------P
MUL_1202|M.ulcerans_Agy99 ---------DYVNAAQPIWWLVRALEFGQDFQTFIKELFTN--------P
MLBr_01828|M.leprae_Br4923 WLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIGADLAAAFA
MAB_2230c|M.abscessus_ATCC_199 -----------AQAAESGMALDDSESFFDKLMRQIQEFFSD--------P
.
Mb3903|M.bovis_AF2122/97 --------------------------------------------------
Rv3873|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5448|M.marinum_M --------------------------------------------------
Mflv_0768|M.gilvum_PYR-GCK -------------RAEGTLRGVVDRAGSHAEKSQGLEQAPQ---------
Mvan_0077|M.vanbaalenii_PYR-1 -------------HAEGLLQQAADSGRSQAEQGQLLQQAPQ---------
TH_4447|M.thermoresistible__bu ---AVAQGNMAAQRAEGTVQKTENLAHQSATRSE--PQQLQ---------
MSMEG_0064|M.smegmatis_MC2_155 -------------HAAAQANFAEQRGQGAAQKGENAGQEAGRES------
MAV_4872|M.avium_104 SAALTQLLRDIWLLIVDEIGHA--IEAFQAFAPQIAAFSLA---------
MUL_1202|M.ulcerans_Agy99 IGAIEFMVELVLFDWPTHIAQI--IQALAQ-SPQLLAVALGGV-------
MLBr_01828|M.leprae_Br4923 SGNPVTIGFTLLFTTIEAIGTI--ITDTIALVKTMIEQSFVLLPMILPLL
MAB_2230c|M.abscessus_ATCC_199 LGTLQKILQDFMRNPLEALVAWGPLLFFIAYEAFFIPFGFTFWG------
Mb3903|M.bovis_AF2122/97 -------------------QLPPAATQTLGQLGEMSG-PMQQLTQPLQQV
Rv3873|M.tuberculosis_H37Rv -------------------QLPPAATQTLGQLGEMSG-PMQQLTQPLQQV
MMAR_5448|M.marinum_M -------------------ELQQTATQ----VAEASG-PMQQLAQPAQQM
Mflv_0768|M.gilvum_PYR-GCK --------QGMQMGMQMASQLGSTLGQMPQQMMQGVTQPFQQLTQPLQQM
Mvan_0077|M.vanbaalenii_PYR-1 --------QGMQMGMQMASQLGSTLGQLPQQMMQGVTQPFQQLTQPLQQM
TH_4447|M.thermoresistible__bu --------QGVQMGMQMGSQLGSTLAQLPQQAGQMISQPMQQLTAPLQQV
MSMEG_0064|M.smegmatis_MC2_155 -------GKNMQQGMQMVMQMGSQAAQAPAQLASMFQSGVQTMTQPLQQA
MAV_4872|M.avium_104 ------LPAGAAAGLAGLSGLAAIQKAAPLPALPAAPPPQPSSMPAVVAG
MUL_1202|M.ulcerans_Agy99 -----VANLGAISGLAGLSGLAGLHSAA----LPAAIAPIAPPMPPGVAL
MLBr_01828|M.leprae_Br4923 TAPLAVATAGAAGSFAGLSELAGLVGVAP-PGLPSAPP--VAAVAPVVPP
MAB_2230c|M.abscessus_ATCC_199 -----VMLSAPLWLPLLLVGLAQLVNPVP--VEADAPADEPAPQQARVER
: .
Mb3903|M.bovis_AF2122/97 TSLFSQVGGTGGGNPADEEAAQMGLLGTSPLSN---HPLAGGSGPSAGAG
Rv3873|M.tuberculosis_H37Rv TSLFSQVGGTGGGNPADEEAAQMGLLGTSPLSN---HPLAGGSGPSAGAG
MMAR_5448|M.marinum_M TSAFSNTGSSGNG--ADEEGFRMGLLGAGALSN---HPLAGGSGPTTGAG
Mflv_0768|M.gilvum_PYR-GCK SSLFGGM--MNGD----K-GAQIGMVGATPFSN---HPAIGGTGPATGSG
Mvan_0077|M.vanbaalenii_PYR-1 SSLFGQMGGLGGD----R-GAQIGMLGATPFSN---HPAIGGSGAATGAG
TH_4447|M.thermoresistible__bu SSVFGQMGGMGSG----D-SAQIGLIGASPFSN---HPLAGGSGPATGAG
MSMEG_0064|M.smegmatis_MC2_155 TQMVSQFASMGGS----ERAMQVGLMGASPFSN---HPMLGGSGPSTGAG
MAV_4872|M.avium_104 PAMGAAAVAAPAPASAGAPAPASATVTASGAA----PPPPSGIGGTAYPY
MUL_1202|M.ulcerans_Agy99 APTVAASVAAPTPPSA--PPSAASTVANAAPP----PPPAPAAAGFGFPF
MLBr_01828|M.leprae_Br4923 SMPTLASIPTPTPMPAP-AASTAPVVTPPGPPPVTAPPSVTGAGVESFGY
MAB_2230c|M.abscessus_ATCC_199 SSPQQQPFAMGG-MPGGGGAPATPANAPATPAN---APASPAAAAATPAY
. . * . .
Mb3903|M.bovis_AF2122/97 LLRAESLPGAGGSLTRTPLMSQLIE---KPVAPSVMPAAAAGSSATGG--
Rv3873|M.tuberculosis_H37Rv LLRAESLPGAGGSLTRTPLMSQLIE---KPVAPSVMPAAAAGSSATGG--
MMAR_5448|M.marinum_M LLRGESLPGAGGTLTRTPLISELVE---KPMGPSVQPAAAAGSSASSG--
Mflv_0768|M.gilvum_PYR-GCK LVRAASLPGAGGSAPQTPLMSNLVGSGLQPT-SPVAVGAGAGPGAGVG--
Mvan_0077|M.vanbaalenii_PYR-1 LVRAASLPGAGGTAARTPLMSNLVGSGLQPTVSAVAVGAGAGAGAGAG--
TH_4447|M.thermoresistible__bu LVRAASLPGLGGTSPTTSLISNLLG-HQNPTAAPAPTGAVAG-GAGTG--
MSMEG_0064|M.smegmatis_MC2_155 LVRAMSLPGAGGTAPRTPLLSNLLG----ISGEMKAAPAGAGSAAAGG--
MAV_4872|M.avium_104 LIGG-PTIGSGTGMGSGAQRKASEPDPAAAAAPAGASAS-ERARARRRRR
MUL_1202|M.ulcerans_Agy99 VVGGGPGIGYGEGMSASAAASARRKAPEPDSAALAAAAA-VREEARRRRR
MLBr_01828|M.leprae_Br4923 LVGRLPSTARGV-VGTSVRQQSSAPDR-IEAPDAAATPQ-EQARSRWRRR
MAB_2230c|M.abscessus_ATCC_199 MVYAVQEDPPAARFGPTLNEGSGAKAPAAGISAAAAAAASARSRARRKRG
:: . :
Mb3903|M.bovis_AF2122/97 --------------------------------AAPVGAGA-------MGQ
Rv3873|M.tuberculosis_H37Rv --------------------------------AAPVGAGA-------MGQ
MMAR_5448|M.marinum_M --------------------------------AAPVGAGG-------MGA
Mflv_0768|M.gilvum_PYR-GCK --------------------------------LAPVGTGGGMGAGGPMGM
Mvan_0077|M.vanbaalenii_PYR-1 --------------------------------LAPVGAGSGMGGGGPMGM
TH_4447|M.thermoresistible__bu --------------------------------PAPIG-GGGMG--APMAA
MSMEG_0064|M.smegmatis_MC2_155 --------------------------------LAPVGAGAGGGAGAPVAH
MAV_4872|M.avium_104 AAMKDRYRGYEFMDVEPDAGPE-PET---DSVTASDRGAGPLGFAGTAP-
MUL_1202|M.ulcerans_Agy99 KRKTERGYGEEFMDVEVDPDWGGPLD---DEPVASTQGAGRLGFAGTVH-
MLBr_01828|M.leprae_Br4923 AKVTP-------FDSSGSPNPK-------AAPTASDQGAGTLGLAGTAR-
MAB_2230c|M.abscessus_ATCC_199 ARIKDPAPQFMDMNSPVDPDFSEPATRHTAGVGASGRGAGQLGFAGTLPR
*. ..
Mb3903|M.bovis_AF2122/97 GAQS--GGSTRPGLVAPAPLAQEREEDDEDDWDEEDDW------------
Rv3873|M.tuberculosis_H37Rv GAQS--GGSTRPGLVAPAPLAQEREEDDEDDWDEEDDW------------
MMAR_5448|M.marinum_M GAGAGAGGSSRPGMAAPATLTQERDEADEDDWDDEDDW------------
Mflv_0768|M.gilvum_PYR-GCK FGQRGKSGGNKPGLNAPAPLDHDLGEDEDEEW------------------
Mvan_0077|M.vanbaalenii_PYR-1 LGQRGKSGGNKPGLNAPAPLEHDLSEDDDDDW------------------
TH_4447|M.thermoresistible__bu MGQNQKSGGSKSGLKAPAPLVQDLSEDEGDDW------------------
MSMEG_0064|M.smegmatis_MC2_155 AGQNSKSGGKKDGLVAPTPLTYDLSEDEDDEW------------------
MAV_4872|M.avium_104 SAP-AQATGLAT-LAGDEFGTGPSMPMVPGNWTGE---------------
MUL_1202|M.ulcerans_Agy99 SESAATAAGLTT-LVADEFGGGPKMPMLPGTWDTDSDAPSD---------
MLBr_01828|M.leprae_Br4923 QASSGPATGLVT-LSNGTFSDSPRAPMLPRTWGADPTFCYNAADIGPAGG
MAB_2230c|M.abscessus_ATCC_199 TTSTTSAAGLIEREAASEMDGTRTVPMLPTSWGTDPEPDPDRAPSVPAPD
. . *
Mb3903|M.bovis_AF2122/97 ------------
Rv3873|M.tuberculosis_H37Rv ------------
MMAR_5448|M.marinum_M ------------
Mflv_0768|M.gilvum_PYR-GCK ------------
Mvan_0077|M.vanbaalenii_PYR-1 ------------
TH_4447|M.thermoresistible__bu ------------
MSMEG_0064|M.smegmatis_MC2_155 ------------
MAV_4872|M.avium_104 ------------
MUL_1202|M.ulcerans_Agy99 ------------
MLBr_01828|M.leprae_Br4923 WDDE--------
MAB_2230c|M.abscessus_ATCC_199 EDWPPGERGAST