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TWPMLWPASVPSECPPNYWHTPAPSAKCEPEQAAVAPIAAAKPMITWLQSAAEQTTTQAEAHRQAMASTP GMAVITENHITQAILATINFFGINMAPIAFTEAGDFICMRTQTALAMNSYQAETLLNTAFQKLEPMAAIL NPSSYSPPSALTSQVNQFTQMISGFSAALPSTQVLQQTVGQVAELARPMQQVKSLFTSIDSTGVYTSAQR GDTESAHRIGLFGASTLSSHPLVGITGTTTDTRLLCAESLPSASGSLAWTPLMTQFQLIDKSIAPEPRQR VMLPPWAAGSPGHNAQDGGTT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_00051 | - | - | 100% (302) | PPE-family protein |
| M. leprae Br4923 | MLBr_01991 | PPE | 1e-10 | 33.90% (118) | PPE-family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 1e-09 | 35.42% (96) | PPE-family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3903 | PPE68 | 5e-51 | 44.86% (292) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0768 | - | 2e-22 | 28.25% (315) | PPE protein |
| M. tuberculosis H37Rv | Rv3873 | PPE68 | 5e-51 | 44.86% (292) | PPE family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 1e-16 | 36.23% (138) | PPE-family protein |
| M. marinum M | MMAR_5448 | - | 6e-48 | 44.53% (265) | PPE family protein |
| M. avium 104 | MAV_0118 | - | 7e-12 | 41.49% (94) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0064 | - | 4e-27 | 28.43% (313) | PPE family protein |
| M. thermoresistible (build 8) | TH_4447 | - | 1e-24 | 30.29% (307) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_4853 | - | 3e-13 | 34.29% (140) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0077 | - | 6e-25 | 29.84% (315) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0768|M.gilvum_PYR-GCK MANIGIPVPPSWVAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
Mvan_0077|M.vanbaalenii_PYR-1 MATIGIPIPPIWGAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
TH_4447|M.thermoresistible__bu ---------MFWHAMPPEVNTSRLMAGAGTAPMLQAAAGWEAFAISLETQ
MSMEG_0064|M.smegmatis_MC2_155 ----------MWIALPPEINTARLMVGAGPAPMLQAAAGWEGLAVLLETQ
Mb3903|M.bovis_AF2122/97 ---------MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQ
Rv3873|M.tuberculosis_H37Rv ---------MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQ
MMAR_5448|M.marinum_M ---------MLWHAMPPELNTARLMAGAGPAPMLAAAAGWEALAAALDAQ
MLBr_00051|M.leprae_Br4923 --------------------MTWPMLWPASVPSECPPNYWHTPAPSAKCE
MAB_0669|M.abscessus_ATCC_1997 ------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNNYANT
MUL_4853|M.ulcerans_Agy99 ------------MAIPPEVHSALLSAGQGPGSLLAAAAQWQELSAQYSAA
MAV_0118|M.avium_104 ------MTAPVWMALPPEVHSTLLSSGPGPGPLLAAAATWTGLSTQYDSA
: .. . .. * .
Mflv_0768|M.gilvum_PYR-GCK ADELASSLA-SLSQNWQGMASERAVTAAMPMVLWLRMLSLQAHKRALQAS
Mvan_0077|M.vanbaalenii_PYR-1 ADELAASLA-TLSQMWQGTASERAVMATMPMVMWLRMLSLQAQKRAAQAS
TH_4447|M.thermoresistible__bu ADELAGSLA-ALAGAWTGGASERAIAAITPMIVWLRTVSAQAHKRSAQAL
MSMEG_0064|M.smegmatis_MC2_155 AAELAAALT-NLTSVWTGAASERAVAATMPMITWLQTTAAQAQKRALQAS
Mb3903|M.bovis_AF2122/97 AVELTARLN-SLGEAWTGGGSDKALAAATPMVVWLQTASTQAKTRAMQAT
Rv3873|M.tuberculosis_H37Rv AVELTARLN-SLGEAWTGGGSDKALAAATPMVVWLQTASTQAKTRAMQAT
MMAR_5448|M.marinum_M AVELTARLN-SLGEAWTGGGSEKALAAALPMVTWLQTASTQAKTRGLQAG
MLBr_00051|M.leprae_Br4923 PEQAAVAP----------------IAAAKPMITWLQSAAEQTTT------
MAB_0669|M.abscessus_ATCC_1997 AVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIAAQHE
MUL_4853|M.ulcerans_Agy99 VVELTQLLAEVQATSWQGYAAHQWLAAHGPYLIWLEQAAIDSSVTAAQHR
MAV_0118|M.avium_104 ATELTAVLTGSMP-VWDGPTADRYVAAHMPYLAWLQLAGALSAEAAAQHQ
: : : * * : **. . :
Mflv_0768|M.gilvum_PYR-GCK AQASSWTVAATGTPQLPEIELNHVTNATLHATNFLGVNGIPIALNEADY-
Mvan_0077|M.vanbaalenii_PYR-1 AQATAWASAATSTPQLPEIETNHITNAVLNATNFLGVNTVPIAVNEADY-
TH_4447|M.thermoresistible__bu AQAAAYSTAMATTPPLAEIEQNHITRAVLHATNFLGINTVPIGINEMDYF
MSMEG_0064|M.smegmatis_MC2_155 AQASSYSLALATTPPLPEIEQNHITHGVLEATNFLGINTVPIALNEMDYF
Mb3903|M.bovis_AF2122/97 AQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYF
Rv3873|M.tuberculosis_H37Rv AQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYF
MMAR_5448|M.marinum_M AQAAAYMQAMATTPSLPEIFANHITNVILNATNFFGINTVPIAFNEMDYF
MLBr_00051|M.leprae_Br4923 -QAEAHRQAMASTPGMAVITENHITQAILATINFFGINMAPIAFTEAGDF
MAB_0669|M.abscessus_ATCC_1997 TTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIALNEADY-
MUL_4853|M.ulcerans_Agy99 IAAAGYSSAVAAMPTLAELAANHAIHGVLVVTNFFGINAIPIALNEADY-
MAV_0118|M.avium_104 GVATAYTAALAAMPTLPELAANHATHAALVATNFFGVNTIPIAVNEADY-
* . * : * :. : ** . * **:*:* **...* .
Mflv_0768|M.gilvum_PYR-GCK IRMWNQAAAVMTAYETETVLNTTFEPVAPPKPIAVPPGSEAAFAGAM---
Mvan_0077|M.vanbaalenii_PYR-1 IRMWNQAAAVMTGYETETILNSTFEPVAPPKPITVFGSTQAAMATAI---
TH_4447|M.thermoresistible__bu VRMWNQAAGAMDVYQAETAMNILFEPIMPMKPIVIPGVGEAAVAGAL---
MSMEG_0064|M.smegmatis_MC2_155 VRMWNQAAGAMDVYHAETTVNLLFEPIMPMKPIVLPGVGETTAAAAL---
Mb3903|M.bovis_AF2122/97 IRMWNQAALAMEVYQAETAVNTLFEKLEPMASILDPGASQST--------
Rv3873|M.tuberculosis_H37Rv IRMWNQAALAMEVYQAETAVNTLFEKLEPMASILDPGASQST--------
MMAR_5448|M.marinum_M VRMWNQAALAMDVYQAETTANTLFEQLEPMTSILDPATAQSMPT------
MLBr_00051|M.leprae_Br4923 ICMRTQTALAMNSYQAETLLNTAFQKLEPMAAILNPSSYSPPS-------
MAB_0669|M.abscessus_ATCC_1997 VRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPGGEARSDQ-----
MUL_4853|M.ulcerans_Agy99 VRMWVQAAETMTTYQAVSEVAAAAVPPTPPAPSILRPGGGSQAAA-----
MAV_0118|M.avium_104 ARMWTQAATTMTTYQATTEAVQMTSVAGSGTGGKAGSGSGSGTGAGTGTG
* *:* .* *.: : .
Mflv_0768|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0077|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4447|M.thermoresistible__bu --------------------------------------------------
MSMEG_0064|M.smegmatis_MC2_155 --------------------------------------------------
Mb3903|M.bovis_AF2122/97 --------------------------------------------------
Rv3873|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5448|M.marinum_M --------------------------------------------------
MLBr_00051|M.leprae_Br4923 --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 ------------------SDVPG----------------SPDQIMKMLQG
MUL_4853|M.ulcerans_Agy99 ------------------SGIGS----------------WIGQLLRDILS
MAV_0118|M.avium_104 TGTGTGTGTGTGTGTGAGSGTGGGTGAGGGGGTGSFQLPTPEEIWEMLFG
Mflv_0768|M.gilvum_PYR-GCK --------SGAVPGAGEAVMRNAIISKVSSTAKLDTANQIAG--------
Mvan_0077|M.vanbaalenii_PYR-1 --------GSAAPGIASAAARNATFTKVSVVGKLDEVNQKAG--------
TH_4447|M.thermoresistible__bu --------GKAAAMAPAAAARDLVFAKVSAQATVESAALQAGRAVA----
MSMEG_0064|M.smegmatis_MC2_155 --------AQTAPRVAEGVMRNAVIEGVSAIATIESVGLAAG--------
Mb3903|M.bovis_AF2122/97 -----------------------------TNPIFGMPSPGSS--------
Rv3873|M.tuberculosis_H37Rv -----------------------------TNPIFGMPSPGSS--------
MMAR_5448|M.marinum_M ----------------------------SSTPLLDMASQVTG--------
MLBr_00051|M.leprae_Br4923 ----------------------------ALTSQVNQFTQMIS--------
MAB_0669|M.abscessus_ATCC_1997 ---------------FQQWFEKMG-FNPATSAVLAVIMLFLYDLL-----
MUL_4853|M.ulcerans_Agy99 F-------LADPYKYFLEFFQRMG-FSPAVAVILAIIALQLYDFL-----
MAV_0118|M.avium_104 PDGEQIPGQGQPNWSPSEYLQNLGNFFNGNAQAVAWLQQNLSGLLNPSQF
.
Mflv_0768|M.gilvum_PYR-GCK -----------------------------------------------RAE
Mvan_0077|M.vanbaalenii_PYR-1 -----------------------------------------------HAE
TH_4447|M.thermoresistible__bu ----------------------------------------QGNMAAQRAE
MSMEG_0064|M.smegmatis_MC2_155 -----------------------------------------------HAA
Mb3903|M.bovis_AF2122/97 --------------------------------------------------
Rv3873|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5448|M.marinum_M --------------------------------------------------
MLBr_00051|M.leprae_Br4923 --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 -----WYPYYASY---------------LLPFLIPA-----------LSG
MUL_4853|M.ulcerans_Agy99 -----WYPYYASYGLL------------LLPFFTPA-----------LSA
MAV_0118|M.avium_104 PALINYFIAWQTYRIINWTIRTLRFILQELPLLLQVGLSLSITSLGGLAG
Mflv_0768|M.gilvum_PYR-GCK GTLRGVVDRAGSHAEKSQGLEQAPQ----QGMQMGMQMASQLGSTLGQMP
Mvan_0077|M.vanbaalenii_PYR-1 GLLQQAADSGRSQAEQGQLLQQAPQ----QGMQMGMQMASQLGSTLGQLP
TH_4447|M.thermoresistible__bu GTVQKTENLAHQSATRSE--PQQLQ----QGVQMGMQMGSQLGSTLAQLP
MSMEG_0064|M.smegmatis_MC2_155 AQANFAEQRGQGAAQKGENAGQEAGRESGKNMQQGMQMVMQMGSQAAQAP
Mb3903|M.bovis_AF2122/97 ------------------------------------TPVGQLPPAATQTL
Rv3873|M.tuberculosis_H37Rv ------------------------------------TPVGQLPPAATQTL
MMAR_5448|M.marinum_M ------------------------------------IPSSELQQTATQ--
MLBr_00051|M.leprae_Br4923 ----------------------------------GFSAALPSTQVLQQTV
MAB_0669|M.abscessus_ATCC_1997 LSGLAALMHLRPAAPGPVPAAALSPGDRPIRRPTQHVEPNLAALPLPTSS
MUL_4853|M.ulcerans_Agy99 LSVLSALAYLANRTP--ITAPVAAPAERSVADLAG-PQPVVGLTPAASAF
MAV_0118|M.avium_104 LAGLAGLAGLAAPASAPAPAAMPQPAGMGAQPPVVSAAPAMAPMAPTSPV
Mflv_0768|M.gilvum_PYR-GCK QQMMQGVTQPFQQLTQPLQQMSSLFGGM--MNGD-----K-GAQIGMVGA
Mvan_0077|M.vanbaalenii_PYR-1 QQMMQGVTQPFQQLTQPLQQMSSLFGQMGGLGGD-----R-GAQIGMLGA
TH_4447|M.thermoresistible__bu QQAGQMISQPMQQLTAPLQQVSSVFGQMGGMGSG-----D-SAQIGLIGA
MSMEG_0064|M.smegmatis_MC2_155 AQLASMFQSGVQTMTQPLQQATQMVSQFASMGGS-----ERAMQVGLMGA
Mb3903|M.bovis_AF2122/97 GQLGEMSG-PMQQLTQPLQQVTSLFSQVGGTGGGNP-ADEEAAQMGLLGT
Rv3873|M.tuberculosis_H37Rv GQLGEMSG-PMQQLTQPLQQVTSLFSQVGGTGGGNP-ADEEAAQMGLLGT
MMAR_5448|M.marinum_M --VAEASG-PMQQLAQPAQQMTSAFSNTGSSGNG---ADEEGFRMGLLGA
MLBr_00051|M.leprae_Br4923 GQVAELAR-PMQQVKSLFTSIDSTGVYTSAQRGD----TESAHRIGLFGA
MAB_0669|M.abscessus_ATCC_1997 VVPSGGSSVPVSTPTAPAHTVSSVPAPSAAISYAIPGLVPPGVSFGPKST
MUL_4853|M.ulcerans_Agy99 APPSPQATSPAPSAPSPAPTGS--PPSSPAISYAVLGPAPPGVSSGPGAT
MAV_0118|M.avium_104 APATSAVSTPAPVASAIAPPATPPVPPAPVTGAEGFGYMVGSFGLGMDSK
. * .
Mflv_0768|M.gilvum_PYR-GCK TPFSNHPAIGGTGPATGSGLVRAASLPGAGGSAPQTPLMSNLVGSGLQPT
Mvan_0077|M.vanbaalenii_PYR-1 TPFSNHPAIGGSGAATGAGLVRAASLPGAGGTAARTPLMSNLVGSGLQPT
TH_4447|M.thermoresistible__bu SPFSNHPLAGGSGPATGAGLVRAASLPGLGGTSPTTSLISNLLG-HQNPT
MSMEG_0064|M.smegmatis_MC2_155 SPFSNHPMLGGSGPSTGAGLVRAMSLPGAGGTAPRTPLLSNLLG----IS
Mb3903|M.bovis_AF2122/97 SPLSNHPLAGGSGPSAGAGLLRAESLPGAGGSLTRTPLMSQLIE---KPV
Rv3873|M.tuberculosis_H37Rv SPLSNHPLAGGSGPSAGAGLLRAESLPGAGGSLTRTPLMSQLIE---KPV
MMAR_5448|M.marinum_M GALSNHPLAGGSGPTTGAGLLRGESLPGAGGTLTRTPLISELVE---KPM
MLBr_00051|M.leprae_Br4923 STLSSHPLVGITGTTTDTRLLCAESLPSASGSLAWTPLMTQFQL------
MAB_0669|M.abscessus_ATCC_1997 EKS-SESAVDTVAAVAAARGAVAAQ--ARRRLRGKNKAEAGGRRHEYLEE
MUL_4853|M.ulcerans_Agy99 TGA-AATATDTTRPAAPA-ALSSSR--AGRRKRSKNRVGVRGYRDEFLQE
MAV_0118|M.avium_104 AQTRARSALAAGRPAASSAGAAAVEQEQGRTRRRPRSVIDPGYRYEFIEG
. . : : .
Mflv_0768|M.gilvum_PYR-GCK -SPVAVGAGAGPGAGVGLAPVGTGGGMGAGGPMGMFGQRGKSGGNKPGLN
Mvan_0077|M.vanbaalenii_PYR-1 VSAVAVGAGAGAGAGAGLAPVGAGSGMGGGGPMGMLGQRGKSGGNKPGLN
TH_4447|M.thermoresistible__bu AAPAPTGAVAG-GAGTGPAPIG-GGGMG--APMAAMGQNQKSGGSKSGLK
MSMEG_0064|M.smegmatis_MC2_155 GEMKAAPAGAGSAAAGGLAPVGAGAGGGAGAPVAHAGQNSKSGGKKDGLV
Mb3903|M.bovis_AF2122/97 APSVMPAAAAGSSATGGAAPVGAGA-------MGQGAQS--GGSTRPGLV
Rv3873|M.tuberculosis_H37Rv APSVMPAAAAGSSATGGAAPVGAGA-------MGQGAQS--GGSTRPGLV
MMAR_5448|M.marinum_M GPSVQPAAAAGSSASSGAAPVGAGG-------MGAGAGAGAGGSSRPGMA
MLBr_00051|M.leprae_Br4923 ---IDKSIAPEPRQRVMLPPWAAGS----------PGHNAQDGGTT----
MAB_0669|M.abscessus_ATCC_1997 TAGMGATATAD---VPAYAATGRGTGPLG--FAGTAP-AAASTHVAATVR
MUL_4853|M.ulcerans_Agy99 PATMDSPIDAPGTAEPAPSPSSQGAGPLG--LTGTA--ASHDGAAAGMVR
MAV_0118|M.avium_104 DDEVVAVASAA---QDRYRPSDSGGSIQG--FAGTLPKSGVRASGLNTLA
. . *
Mflv_0768|M.gilvum_PYR-GCK APAPLDHDLGEDEDEEW-----------
Mvan_0077|M.vanbaalenii_PYR-1 APAPLEHDLSEDDDDDW-----------
TH_4447|M.thermoresistible__bu APAPLVQDLSEDEGDDW-----------
MSMEG_0064|M.smegmatis_MC2_155 APTPLTYDLSEDEDDEW-----------
Mb3903|M.bovis_AF2122/97 APAPLAQEREEDDEDDWDEEDDW-----
Rv3873|M.tuberculosis_H37Rv APAPLAQEREEDDEDDWDEEDDW-----
MMAR_5448|M.marinum_M APATLTQERDEADEDDWDDEDDW-----
MLBr_00051|M.leprae_Br4923 ----------------------------
MAB_0669|M.abscessus_ATCC_1997 LSSDEARQVIPMLPSTWDADGGDQN---
MUL_4853|M.ulcerans_Agy99 LSSHGTSTAVPLLPATWTNDSEGRPEGE
MAV_0118|M.avium_104 GNESGDGARIPMLPESWDGP--------