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MTAPLWMASAPEAHSALLSAGPGPGSLLAAAQTWTELSAEYLAVAEELTAILTGVQAGAWDGPSAQCCIA AYLPYLSWLMQASADSAATAAAHQAAATAYTGALAAMPTLGELAANHATHAVLVATNFFGLNTIPIALNE VDYVRMWIQAATTMSVYQAVAADALLAVPRTPPAPVIIKPGADAAAQFASAVVQAVAETPIQRLLLELAT LVGAEFINVFELIVGIVVLSTYGLKLPLLALLDFLTGHFSVALSLLWNYAMLWFGFVVPPALQIVFDPLL VVAAVIEWILGGGAALGSVGALDANLAAGLALAAVAAAPVADAAVGSLGVLTSAAAVTAAAAAAPGQGVG LVGFAATMPNPTTLPAGGLVTVGGADPCAGARVPMLPASWVALG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1154 | - | - | 100% (394) | PPE family protein |
| M. ulcerans Agy99 | MUL_1208 | - | 3e-74 | 44.39% (401) | PPE family protein |
| M. ulcerans Agy99 | MUL_1202 | - | 8e-65 | 41.04% (402) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3047c | PPE47 | 4e-86 | 46.28% (430) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 3e-73 | 44.62% (390) | PPE protein |
| M. tuberculosis H37Rv | Rv3018c | PPE46 | 2e-84 | 44.70% (434) | PPE family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 1e-55 | 37.77% (421) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 6e-69 | 41.11% (377) | PPE family protein |
| M. marinum M | MMAR_0491 | - | 0.0 | 98.73% (393) | PPE family protein |
| M. avium 104 | MAV_4867 | - | 2e-75 | 45.50% (400) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 5e-74 | 43.80% (395) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 2e-68 | 63.27% (196) | PUTATIVE PPE protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 3e-71 | 43.60% (406) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_1154|M.ulcerans_Agy99 ----------MTA---PLWMASAPEAHSALLSAGPGPGSLLAAAQTWTEL
MMAR_0491|M.marinum_M ----------MTA---PLWMASAPEVHSALLSAGPGPGSLLAAAQTWTEL
Mb3047c|M.bovis_AF2122/97 ----------MTA---PVWLASPPEVHSALLSAGPGPGSLQAAAAGWSAL
Rv3018c|M.tuberculosis_H37Rv ----------MTA---PVWLASPPEVHSALLSAGPGPGSLQAAAAGWSAL
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTS---PVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSL
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSS---PVWMALPPEVHSALLSSGPGPGSMLAAAATWQSL
MSMEG_0619|M.smegmatis_MC2_155 ----------MTA---PIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSL
TH_3569|M.thermoresistible__bu ---------MMTA---PIWMALPPEVHSALLSSGPGPGSLLAAASAWHAL
MAB_4783|M.abscessus_ATCC_1997 ----------MTA---PVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSL
MAV_4867|M.avium_104 ----------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSL
MLBr_01828|M.leprae_Br4923 ----------MSA---PIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSL
::: *:*:* .**.**::** ***.*.: .*. * *
MUL_1154|M.ulcerans_Agy99 SAEYLAVAEELTAILTGVQAGAWDGPSAQCCIAAYLPYLSWLMQASADSA
MMAR_0491|M.marinum_M SAEYLAVAEELTAILTGVQAGAWDGPSAQCCIAAYVPYLSWLMQASADSA
Mb3047c|M.bovis_AF2122/97 SAEYAAVAQELSAVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSA
Rv3018c|M.tuberculosis_H37Rv SAEYAAVAQELSVVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSA
Mflv_0325|M.gilvum_PYR-GCK SAEYASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSA
Mvan_0415|M.vanbaalenii_PYR-1 SAEYAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGA
MSMEG_0619|M.smegmatis_MC2_155 SAEYAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSA
TH_3569|M.thermoresistible__bu SAEYASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSA
MAB_4783|M.abscessus_ATCC_1997 STEYSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSA
MAV_4867|M.avium_104 SAQYATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSA
MLBr_01828|M.leprae_Br4923 SSVYAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSA
*: * * ** : . . *:* :: *: **: ** : *. .*
MUL_1154|M.ulcerans_Agy99 ATAAAHQAAATAYTGALAAMPTLGELAANHATHAVLVATNFFGLNTIPIA
MMAR_0491|M.marinum_M ATAAAHQAAATAYTGALAAMPTLGELAANHATHAVLVATNFFGLNTIPIA
Mb3047c|M.bovis_AF2122/97 AAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIA
Rv3018c|M.tuberculosis_H37Rv AAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIA
Mflv_0325|M.gilvum_PYR-GCK ATAVQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIA
Mvan_0415|M.vanbaalenii_PYR-1 AAAAQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIA
MSMEG_0619|M.smegmatis_MC2_155 AAAVQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIA
TH_3569|M.thermoresistible__bu ATAGRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIA
MAB_4783|M.abscessus_ATCC_1997 GVAAQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIA
MAV_4867|M.avium_104 GAAAQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIA
MLBr_01828|M.leprae_Br4923 VMAAHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIA
* :. *:.* :** ***: **: *: * .*: ***:*:******
MUL_1154|M.ulcerans_Agy99 LNEVDYVRMWIQAATTMSVYQAVAADALLAVPRTPPAPVIIKPGADAAA-
MMAR_0491|M.marinum_M LNEVDYVRMWIQAATTMSVYQAVAADALLAVPRTPPAPVIIKPGADAAA-
Mb3047c|M.bovis_AF2122/97 LNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASN
Rv3018c|M.tuberculosis_H37Rv LNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASN
Mflv_0325|M.gilvum_PYR-GCK LNEADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGR
Mvan_0415|M.vanbaalenii_PYR-1 MTEADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGR
MSMEG_0619|M.smegmatis_MC2_155 LNEADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGS
TH_3569|M.thermoresistible__bu LNEADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAAD
MAB_4783|M.abscessus_ATCC_1997 VNEADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAAR
MAV_4867|M.avium_104 VNEADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPG-GEANN
MLBr_01828|M.leprae_Br4923 RNEIDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASS
.* ** ***::** *..*: * : :.* : .** :: .. *
MUL_1154|M.ulcerans_Agy99 QFASA----------------------------VVQAVAETPIQRLLLEL
MMAR_0491|M.marinum_M QFASA----------------------------VVQAVAETPIQRLLLEL
Mb3047c|M.bovis_AF2122/97 AVAAA----------------------------TITPFPFGELAKFLEMA
Rv3018c|M.tuberculosis_H37Rv AVAAA----------------------------TITPFPWHEIVQFLEET
Mflv_0325|M.gilvum_PYR-GCK AAADMSAFAA--------------------QPMAAQAGAAFDVSNIIADI
Mvan_0415|M.vanbaalenii_PYR-1 AAADVTAFAA--------------------QAQAAEAGSALDLSNIIADL
MSMEG_0619|M.smegmatis_MC2_155 ASASVQQMSA--------------------QATAAESGSSLDLSSIISDL
TH_3569|M.thermoresistible__bu AMATTQQIGS--------------------QATAADSGTALNLSDLIANL
MAB_4783|M.abscessus_ATCC_1997 TAA---------------------------QDATKPPPIVPDPNDPIEML
MAV_4867|M.avium_104 LAAN-----------------------------AAQNSS----GDWWQNF
MLBr_01828|M.leprae_Br4923 DQPSPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGM
. .
MUL_1154|M.ulcerans_Agy99 ATLVG-----------AE--------------FINVFELIVGIVVLSTYG
MMAR_0491|M.marinum_M ATLVG-----------AE--------------FINVFELIVGIVVLSTYG
Mb3047c|M.bovis_AF2122/97 AQAFTEVGELIMKSAEAW--------------AVGFVELITGLVNFEPWL
Rv3018c|M.tuberculosis_H37Rv FAAYDQYLSALLSELPAV--------------AWVWFQLFVDILGFNIIG
Mflv_0325|M.gilvum_PYR-GCK IRLYGEVLRFLFEPIFNF--------------LRDPIGNTFALITDFLTN
Mvan_0415|M.vanbaalenii_PYR-1 IRAYGELLRFLFEPIFDF--------------LRDPLGNTIKLITDFLTN
MSMEG_0619|M.smegmatis_MC2_155 LNQYLQGVPGGQ-AILDF--------------LKDPLGNLGRLLTDFMTN
TH_3569|M.thermoresistible__bu LQYYQDYLDQLFGPIVDF--------------LRDPIGNLFQLIDDFLTN
MAB_4783|M.abscessus_ATCC_1997 LKNSQHFL-GMYRALKGL--------------ITDPVGTIVRIIIDFSTN
MAV_4867|M.avium_104 IQQLSQFF-----------------------------QNIQKMLQDFWAN
MLBr_01828|M.leprae_Br4923 FSGFDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIGAD
.
MUL_1154|M.ulcerans_Agy99 LKLPLL----ALLDFLTGHFS-VALSLLWN----YAMLWFGFVVP---PA
MMAR_0491|M.marinum_M LKLPLL----ALLDFLTGHFS-VALSLLWN----YAMLWFGFVVL---PA
Mb3047c|M.bovis_AF2122/97 VLTGMIDMFFATVGFALGVFV-LVPLLEFAVVLELAILSIGWIISNIFGA
Rv3018c|M.tuberculosis_H37Rv FIITLASNAQLLTEFAINASY-VAVGLLYAIAGVIDIV-VEWVIGNLFGV
Mflv_0325|M.gilvum_PYR-GCK PVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLPLLATTLAIVAGVGQ
Mvan_0415|M.vanbaalenii_PYR-1 PAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPLVATTLAIVLGVGA
MSMEG_0619|M.smegmatis_MC2_155 PAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPFLIPALAALGITGL
TH_3569|M.thermoresistible__bu PAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPVLIPLAITLGVAGL
MAB_4783|M.abscessus_ATCC_1997 PAAAIVTWTPLFYVFAYAATFAVMGTPIYAAIMGP---AAGISIPLAITL
MAV_4867|M.avium_104 LPAFLAANGPLLFFVAYQVFFNAVGWPTWGAILTAP---FLLPLLLGIGL
MLBr_01828|M.leprae_Br4923 LAAAFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPMI
: .
MUL_1154|M.ulcerans_Agy99 LQIVFDPLL--VVAAVIEWILG----------------------------
MMAR_0491|M.marinum_M LQIVFDPLL--VVAAVIEWILG----------------------------
Mb3047c|M.bovis_AF2122/97 IPVLAGPLLGALAAAVVPGVAGVT--------------------------
Rv3018c|M.tuberculosis_H37Rv VPLLGGPLLGALAAAVVPGVAGLA--------------------------
Mflv_0325|M.gilvum_PYR-GCK HLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIA
Mvan_0415|M.vanbaalenii_PYR-1 YLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAAT
MSMEG_0619|M.smegmatis_MC2_155 VLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVGISPAGVPGSAATA
TH_3569|M.thermoresistible__bu VMIADQAQP-----PAEEAAPEEDVAAP-------------------VRA
MAB_4783|M.abscessus_ATCC_1997 ASLSQMPEAPPVDAPAETVPARIDQPHAVAMGGAPAPTASTAAP--TPTT
MAV_4867|M.avium_104 SSLLAAPAEIAPVAAPAAITPVLASNKPPTLPAAVALAPSVATPAGAPAS
MLBr_01828|M.leprae_Br4923 LPLLTAPLAVATAGAAGSFAGLSELAGLVGVAPPGLPSAPPVAAVAPVVP
: .
MUL_1154|M.ulcerans_Agy99 -GGAALGSVGALDANLAAGLALAAV-------------------------
MMAR_0491|M.marinum_M -GGAALGSVGALGANLAAGLALPAV-------------------------
Mb3047c|M.bovis_AF2122/97 -GLAGLAAVPAVGAAAGAPAALVG--------------------------
Rv3018c|M.tuberculosis_H37Rv -GVAGLAALPAVGAAAGAPAALVG--------------------------
Mflv_0325|M.gilvum_PYR-GCK ANTVSAGSPPAPGAPAAAAATFVPYVVAGRDPYEGFSPTVRDS-------
Mvan_0415|M.vanbaalenii_PYR-1 VGTVATGTAPAPGAPAAATASFVPYAVAGRDPGTGFSPTVRDS-------
MSMEG_0619|M.smegmatis_MC2_155 AAPAPAPAGTTVAAPAPAAATFVPYAVANRDPGEGFTPTLGNK-------
TH_3569|M.thermoresistible__bu EPQNPLPLTXXX--------------------------------------
MAB_4783|M.abscessus_ATCC_1997 TSPATPGSAPAP-TPPPAGAEGLGYAVRGDGPGFGFGPTIGAS-------
MAV_4867|M.avium_104 TVAAGSGAAAAP-GPAAAAGNFAYLVAFGGDPDTGVGPTLSGR-------
MLBr_01828|M.leprae_Br4923 PSMPTLASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPSVTGAGVESFGY
MUL_1154|M.ulcerans_Agy99 ----AAAPVADAAVGSLGVLTS----------------------------
MMAR_0491|M.marinum_M ----AAAPVADAAVGSLGVLTS----------------------------
Mb3047c|M.bovis_AF2122/97 ----SVAPVSGGVVSPQARLVSAVEP------------------------
Rv3018c|M.tuberculosis_H37Rv ----SVAPVSGGVVSPQARLVSAVEP------------------------
Mflv_0325|M.gilvum_PYR-GCK --TGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADAYADYE
Mvan_0415|M.vanbaalenii_PYR-1 --TSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADAYADYE
MSMEG_0619|M.smegmatis_MC2_155 --SQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADAYMDYE
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 --TGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRGYRHEYATMD
MAV_4867|M.avium_104 --GGAKAPAATIPAAGAAAPARAEARARRRRRAALHDYSDEFLDMDSGFG
MLBr_01828|M.leprae_Br4923 LVGRLPSTARGVVGTSVRQQSSAPDRIEAPDAAATPQEQARSRWRRRAKV
MUL_1154|M.ulcerans_Agy99 ------AAAVTAAAAAAPGQGVGLVGFAATMPNPTT-LPAGGLVTVGGAD
MMAR_0491|M.marinum_M ------AAAVTAAAAAAPGQGVGLVGFAATMPNPTT-LPAGGLVTVGGAD
Mb3047c|M.bovis_AF2122/97 ------APASTSVSVLASDRGAGALGFVGTAGKESVGQPAG--LTVLADE
Rv3018c|M.tuberculosis_H37Rv ------APASTSVSVLASDRGAGALGFVGTAGKESVGQPAG--LTVLADE
Mflv_0325|M.gilvum_PYR-GCK ELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRG-DEQAGG-LTTLAGDS
Mvan_0415|M.vanbaalenii_PYR-1 PEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRD-AAQAGG-LTTLPGDP
MSMEG_0619|M.smegmatis_MC2_155 E-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRH-DVTAAG-LTTLTGDT
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 DHTPTGP--QDPVTAVASGTGAGRLGFAGVHTATTAVEATG-LSTLDGDA
MAV_4867|M.avium_104 VPPDYGAEEELAA-AVASGQGAGTLGFAGTQQRRKAFQAAG-LTKLADDD
MLBr_01828|M.leprae_Br4923 TPFDSSGSPNPKAAPTASDQGAGTLGLAGTARQASSGPATG-LVTLSNGT
MUL_1154|M.ulcerans_Agy99 PCAGARVPMLPASW----VALG-----------------
MMAR_0491|M.marinum_M PCAGARVPMLPASW----VALA-----------------
Mb3047c|M.bovis_AF2122/97 FGDGAPVPMLPGSWGPDLVGVAGDGGLVSV---------
Rv3018c|M.tuberculosis_H37Rv FGDGAPVPMLPGSWGPDLVGVAGDGGLVSV---------
Mflv_0325|M.gilvum_PYR-GCK FGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 FGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 FDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu ---------------------------------------
MAB_4783|M.abscessus_ATCC_1997 EN--RTIPMLPGTWDVTDDDR------------------
MAV_4867|M.avium_104 FGGSPRMPMVPGTWEQDTQNG-------AHPTEPGKGG-
MLBr_01828|M.leprae_Br4923 FSDSPRAPMLPRTWGADPTFCYNAADIGPAGGWDDE---