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VGVQKVLISGASVAGLTTAYWLEQQGYSVTIVERHPGLRPGGQAIDVRGPALTVLDRMGILDAARDRKTG IRGASVVDRDGNELSQDTESTPTGGPIDSPNIELLRDDLIELLYGTIQSTTEFIFDDSIATLQDDGAAVE VTFVRSGTRTFDFLIGADGLHSNVRRKVFGPEEQFIKRLGTYAAIFTVPNFLELDYWQKWHYGDNTMAGV YSARDNSEARAALGFMDTELQIDYRDTEAQFAELERRMIEDGWVRAQLLHYMRSAPDFYFDEMAQIVMDS WSKGRVALVGDAAYCCSPLSGQGTSVAVLGAYILAGELAAAGNDYQRGFANYHAEFSGFVERNQWLVTDN IPGGEPIPEEAFERIVNSLELEDYRQG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4180 | - | - | 100% (378) | oxidoreductase |
| M. marinum M | MMAR_2185 | - | 2e-63 | 41.12% (321) | oxidoreductase |
| M. marinum M | MMAR_4675 | - | 3e-63 | 41.40% (343) | membrane-associated oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1290 | - | 1e-120 | 78.46% (260) | hypothetical protein Mb1290 |
| M. gilvum PYR-GCK | Mflv_2621 | - | 4e-12 | 24.34% (341) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv1260 | - | 1e-180 | 80.11% (372) | hypothetical protein Rv1260 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0649c | - | 9e-75 | 40.91% (352) | putative monooxygenase |
| M. avium 104 | MAV_1408 | - | 1e-165 | 75.00% (372) | hypothetical protein MAV_1408 |
| M. smegmatis MC2 155 | MSMEG_3039 | - | 2e-61 | 39.94% (353) | monooxygenase |
| M. thermoresistible (build 8) | TH_2800 | - | 1e-08 | 25.15% (342) | PUTATIVE putative monooxygenase, FAD-binding |
| M. ulcerans Agy99 | MUL_4482 | - | 0.0 | 98.94% (378) | hypothetical protein MUL_4482 |
| M. vanbaalenii PYR-1 | Mvan_3960 | - | 3e-13 | 26.50% (317) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2621|M.gilvum_PYR-GCK ----MSARISVIGAGISGLAAAVALERAGHHVSVIEQRTDTGAG-SGISL
Mvan_3960|M.vanbaalenii_PYR-1 ----MPAHTIVIGAGIAGLATAVALRRVGHDVTVIEQRTDLTSG-AGISI
MMAR_4180|M.marinum_M --MVGVQKVLISGASVAGLTTAYWLEQQGYSVTIVERHPGLRPGGQAIDV
MUL_4482|M.ulcerans_Agy99 --MVGVQKVLISGASVAGLTTAYWLEQQGYSVTIVERHPGLRPGGQAIDV
Mb1290|M.bovis_AF2122/97 -----MKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLRPGGQAIDV
Rv1260|M.tuberculosis_H37Rv -----MKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLRPGGQAIDV
MAV_1408|M.avium_104 -----MSDVLVSGASVAGTAAAFWLGRHGHSVTVVERHRGPRPGGQAIDV
MAB_0649c|M.abscessus_ATCC_199 ----MSREILISGGGIAGPALAYWLVQEGHSVTIVERAATVRNGGQAVDF
MSMEG_3039|M.smegmatis_MC2_155 ---MGQPTVLISGAGVAGTSLAHWLTEYGYRAVVVETAPTLRLGGQTVDL
TH_2800|M.thermoresistible__bu VSGPEQAPVLIVGAGPAGLATAYVLGRNGIPSVVCDQHSGIHPHPRAHVI
: *.. :* : * * . * : : .
Mflv_2621|M.gilvum_PYR-GCK WPNALAALDQIGLGDSVRDAGGRVTAGAIRWRDGTWVRRPSVR----RIV
Mvan_3960|M.vanbaalenii_PYR-1 WPNALAALDQIGLGDNVRQAGGRVTAGAIRWRDGTWLRRPSAQ----RIV
MMAR_4180|M.marinum_M RGPALTVLDRMGILDAARDRKTGIRGASVVDRDGNELSQDTES---TPTG
MUL_4482|M.ulcerans_Agy99 RGPALTVLDRMGILDAARDRKTGIRGASVVDRDGNELSRDTES---TPTG
Mb1290|M.bovis_AF2122/97 RGPALDVLERMGLLAAAQEHKTRIRGASFVDRDGNELFRDTES---TPTG
Rv1260|M.tuberculosis_H37Rv RGPALDVLERMGLLAAAQEHKTRIRGASFVDRDGNELFRDTES---TPTG
MAV_1408|M.avium_104 RGPALGVLERMGLLAAAAKRRTQIRGSSVVDRDGNELSRDTEAAISGPTG
MAB_0649c|M.abscessus_ATCC_199 RGPSIDVLDKMGVLDAVRAQATHMGSLVMVDADGKEIAR---------FP
MSMEG_3039|M.smegmatis_MC2_155 RGAGRDVVTRMGLLDEMRARSLDQRGIAWVRGNGRRRAEMPVD----AFD
TH_2800|M.thermoresistible__bu NTRSMELFRSWGIADAIARDEQAFDAGAGVRIVWKHSVSGEELGCIDLLD
. . *: .
Mflv_2621|M.gilvum_PYR-GCK DALGEPL----------VVVRRSRLTDILREALPA-GTVRTGLAATRVSV
Mvan_3960|M.vanbaalenii_PYR-1 HALGEPL----------VVVRRSALTEILLDALPP-DTVQTGLSATALSI
MMAR_4180|M.marinum_M GPIDSPN----------IELLRDDLIELLYGTIQSTTEFIFDDSIATLQD
MUL_4482|M.ulcerans_Agy99 GPIDSPN----------IELLRDDLIELLDGTIQSTTEFIFDDSIATLQD
Mb1290|M.bovis_AF2122/97 GPVNSPD----------IELLRDDLVELLYGATQPSVEYLFDDSISTLQD
Rv1260|M.tuberculosis_H37Rv GPVNSPD----------IELLRDDLVELLYGATQPSVEYLFDDSISTLQD
MAV_1408|M.avium_104 GPIEGPD----------IELLRDDLVELLYGASQWTAEYLFDDTITALDD
MAB_0649c|M.abscessus_ATCC_199 SEVISGE----------LEILWGDLARILHEAVREHVVFRFADSITGVRD
MSMEG_3039|M.smegmatis_MC2_155 GNGMVSA----------LEILRGDLVEVLYNATSARAEYRFGTRITEIDS
TH_2800|M.thermoresistible__bu APVESIERRRAASPVGLISCPQDRIQRLMVDAVLRQGMSRIDYDTRVVEI
: . : :: : :
Mflv_2621|M.gilvum_PYR-GCK GASSVRITLSDGEVRE-----SDAVVGADGVNSVLARTLNGP-------L
Mvan_3960|M.vanbaalenii_PYR-1 AAATARVTLSDGRTRE-----ADAVVGADGVNSMVARALNGP-------L
MMAR_4180|M.marinum_M DGAAVEVTFVRSGTRT-----FDFLIGADGLHSNVRRKVFGPEEQFIKRL
MUL_4482|M.ulcerans_Agy99 DGAAVEVTFVRSGTRT-----FDFLIGADGLHSNVRRKVFGPEEQFIKRL
Mb1290|M.bovis_AF2122/97 DGDSVRVTFERAAARE-----FDLVIGADGLHSNVRRLVFGPEEQFVKRL
Rv1260|M.tuberculosis_H37Rv DGDSVRVTFERAAARE-----FDLVIGADGLHSNVRRLVFGPEEQFVKRL
MAV_1408|M.avium_104 RGAAVRVSFERAAPRD-----FDLVIGADGLHSNVRRLVFGPEDEFIERL
MAB_0649c|M.abscessus_ATCC_199 DGAKVTVSFSRSAPES-----YDLLIGADGVHSGVRALTFGPEHEFVTQL
MSMEG_3039|M.smegmatis_MC2_155 SG----ATLSDGTRVD-----ADLIVGADGPHSSVRRMVFGPEEQYVTLL
TH_2800|M.thermoresistible__bu TDAATGVEVTAESRGKPRRFRADYVVNAEGAGGRLR-SALGIEMDGIPFI
. * ::.*:* . : * :
Mflv_2621|M.gilvum_PYR-GCK RTRYVGYTAWRGIAAHPLDPELGGETLGPGTQVGHVPLG-PDHTYWFATE
Mvan_3960|M.vanbaalenii_PYR-1 PSRYVGYTAWRGVAAYRLDPALAGETMSAGTEVGHVPLG-PDHTYWFATE
MMAR_4180|M.marinum_M GTYAAIFTVPNFLELDYWQKWHYGDNTMAGVYSARDNSE-ARAALGFMDT
MUL_4482|M.ulcerans_Agy99 GTYAAIFTVPNFLELDYWQKWHYGDNTMAGVYSARDNSE-ARAALGFMDT
Mb1290|M.bovis_AF2122/97 GTHAAIFTVPNFLELDYWQTWHYGDSTMAGVYSARNNTE-ARAALAFMDT
Rv1260|M.tuberculosis_H37Rv GTHAAIFTVPNFLELDYWQTWHYGDSTMAGVYSARNNTE-ARAALAFMDT
MAV_1408|M.avium_104 GTHAAIFTVPNFLGLDYWQMWHYGDSTMAGVYSARDNAE-ARAMLGFMDA
MAB_0649c|M.abscessus_ATCC_199 GQYFTFFAMDNHLGLDHQTVGFREGTRGVGIQATAPDAP-ARGSLSFSDD
MSMEG_3039|M.smegmatis_MC2_155 GGYNAWFTAPDTAGLDGWYLMYQVPGLNASMRPSHDPAL-CKAGLAFRSG
TH_2800|M.thermoresistible__bu ADQVTSYFHADLSEWTGERPPLLQWIINTDVQGTFIAMGQNRWTFTIGFG
. : . :
Mflv_2621|M.gilvum_PYR-GCK RTAEGGSAPGGEHAYLTAKVADWADPIPRLVATTDPGDLLRNDLYDRARA
Mvan_3960|M.vanbaalenii_PYR-1 RTREGSRSAGGEHAYLTAKLAGWADPIPALLASTDPADVLRNDLYDRAQP
MMAR_4180|M.marinum_M ELQIDYRDTEAQFAELERRMIEDGWVRAQLLHYMRSAPDFYFDEMAQIVM
MUL_4482|M.ulcerans_Agy99 ELQIDYRDTEAQFAELERRMIEDGWVRAQLLHYMRSAPDFYFDEMAQIVM
Mb1290|M.bovis_AF2122/97 ELRIDYRDTEAQFAELQRRMAEDGWVRAQLLHYIAAH---------RISI
Rv1260|M.tuberculosis_H37Rv ELRIDYRDTEAQFAELQRRMAEDGWVRAQLLHYMRSAPDFYFDEMSQILM
MAV_1408|M.avium_104 ELRLDYRDTEAQFAELERRMAGEGWVRPQLLEYMRTAPDFYFDEMSQIKM
MAB_0649c|M.abscessus_ATCC_199 HLEFDYRDVEGNKKLFSERFTGFGWETPAVLRALSVTAEPYFDSLCQVHL
MSMEG_3039|M.smegmatis_MC2_155 PVDYDRRDPATQLALLNTHFAGAGWHCADLLAAAAVADDFYFDAFLQVHM
TH_2800|M.thermoresistible__bu ATDEARRALDPQRCVELIRLAIGPAGSDVDIDFRSAG----SWTLCATTA
: :. :
Mflv_2621|M.gilvum_PYR-GCK ARWSDGRAVLIGDAAHPMRPHLGQGGCQGIEDAAILARFLELAD-----D
Mvan_3960|M.vanbaalenii_PYR-1 RDWSRGPAVIVGDAAHPMRPHLGQGGCQGLEDAAILARFVGLSP-----D
MMAR_4180|M.marinum_M DSWSKGRVALVGDAAYCCSPLSGQGTSVAVLGAYILAGELAAAG----ND
MUL_4482|M.ulcerans_Agy99 DSWAKGRVALVGDAAYCCSPLSGQGTSVAVLGAYILAGELAAAG----ND
Mb1290|M.bovis_AF2122/97 STKCRRS-------------------------------------------
Rv1260|M.tuberculosis_H37Rv DRWSRGRVALVGDAGYCCSPLSGQGTSVALLGAYILAGELKAAG----DD
MAV_1408|M.avium_104 DRWSRGRVALVGDAGYCCSPLSGQGTSVALLGAYILAGELKAAG----ED
MAB_0649c|M.abscessus_ATCC_199 DTYSRGRVCLLGDAAWCASPRSGMGTSLAIVGAYVLAHELRSAQ----GD
MSMEG_3039|M.smegmatis_MC2_155 PTLSRGPVTLVGDAGYCASPLSGMGTSLALVGAYVLAGELGPADMFAHAK
TH_2800|M.thermoresistible__bu RTYRAGRVFLVGDAAHQFPPTGGFGMNTGLADADNLGWKLAAVLHG--WA
Mflv_2621|M.gilvum_PYR-GCK VPTAFERFEAFRKPRVGMLVREAQTLGRIVNVRPAVLSG--LAGRATALI
Mvan_3960|M.vanbaalenii_PYR-1 LPAAFDRFGAFRRRRVRPLVRESAAIGRIVNLRPAFLSG--VASRASALI
MMAR_4180|M.marinum_M YQRGFANYHAEFSGFVERNQWLVTDN-----------------------I
MUL_4482|M.ulcerans_Agy99 YQRGFANYHAEFSGFGERNQWLVTDN-----------------------I
Mb1290|M.bovis_AF2122/97 --------------------------------------------------
Rv1260|M.tuberculosis_H37Rv YQLGFANYHAEFHGFVERNQWLVSDN-----------------------I
MAV_1408|M.avium_104 HEAGFANYHREFADYVQRNQWLVVDN-----------------------I
MAB_0649c|M.abscessus_ATCC_199 FSIAFARFHTLMAPYAARCQRLALDALKIGEADSPWATGLRRLGLWSLRL
MSMEG_3039|M.smegmatis_MC2_155 LGLALSRYESTMRPYIERCQDLPTGIDG-YLPKSALDITIYTQVMKWMQR
TH_2800|M.thermoresistible__bu DEELLDTYESERRPVALANSEFSVTNALKMASTGIGPTGPQFAAELESDD
Mflv_2621|M.gilvum_PYR-GCK PERMVTA-------------HLAWIAAGSAFVLPTAADLAR---------
Mvan_3960|M.vanbaalenii_PYR-1 PEWAVAS-------------HLASIAAGSAFILPTAGDVGG---------
MMAR_4180|M.marinum_M PGGEPIP-------------EEAFERIVNSLELEDYRQG-----------
MUL_4482|M.ulcerans_Agy99 PGGEPIP-------------EEAFERIVNSLELEDYRQG-----------
Mb1290|M.bovis_AF2122/97 --------------------------------------------------
Rv1260|M.tuberculosis_H37Rv PGGAPIP-------------QEEFERIVHSITIKDY--------------
MAV_1408|M.avium_104 PGGAPIP-------------QEVFERIVASITLKDY--------------
MAB_0649c|M.abscessus_ATCC_199 PGIRQLV-------------ARQALKVGRSFALPAYD-------------
MSMEG_3039|M.smegmatis_MC2_155 WPIRSYA-------------ARKWFTTADAIQLPSYPAAQNKR-------
TH_2800|M.thermoresistible__bu PSVAAAVRDRIRNAIPEQRPHFDHLELEIGYVYPGDASDGDPVSTPVVGG
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3960|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4180|M.marinum_M --------------------------------------------------
MUL_4482|M.ulcerans_Agy99 --------------------------------------------------
Mb1290|M.bovis_AF2122/97 --------------------------------------------------
Rv1260|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1408|M.avium_104 --------------------------------------------------
MAB_0649c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3039|M.smegmatis_MC2_155 --------------------------------------------------
TH_2800|M.thermoresistible__bu RLPHRWITRITPGQGTASTLDLLGDGFTLLTGPAGAAWTAGVRDVAVPVR
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3960|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4180|M.marinum_M --------------------------------------------------
MUL_4482|M.ulcerans_Agy99 --------------------------------------------------
Mb1290|M.bovis_AF2122/97 --------------------------------------------------
Rv1260|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1408|M.avium_104 --------------------------------------------------
MAB_0649c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3039|M.smegmatis_MC2_155 --------------------------------------------------
TH_2800|M.thermoresistible__bu TLTAGVDFAFTGPSDTTFLADDGAVLVRPDGHIAWIATHLPADPAAELTS
Mflv_2621|M.gilvum_PYR-GCK ----------------------
Mvan_3960|M.vanbaalenii_PYR-1 ----------------------
MMAR_4180|M.marinum_M ----------------------
MUL_4482|M.ulcerans_Agy99 ----------------------
Mb1290|M.bovis_AF2122/97 ----------------------
Rv1260|M.tuberculosis_H37Rv ----------------------
MAV_1408|M.avium_104 ----------------------
MAB_0649c|M.abscessus_ATCC_199 ----------------------
MSMEG_3039|M.smegmatis_MC2_155 ----------------------
TH_2800|M.thermoresistible__bu ALRGVHLSADAARSASGQGASR