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GQPTVLISGAGVAGTSLAHWLTEYGYRAVVVETAPTLRLGGQTVDLRGAGRDVVTRMGLLDEMRARSLDQ RGIAWVRGNGRRRAEMPVDAFDGNGMVSALEILRGDLVEVLYNATSARAEYRFGTRITEIDSSGATLSDG TRVDADLIVGADGPHSSVRRMVFGPEEQYVTLLGGYNAWFTAPDTAGLDGWYLMYQVPGLNASMRPSHDP ALCKAGLAFRSGPVDYDRRDPATQLALLNTHFAGAGWHCADLLAAAAVADDFYFDAFLQVHMPTLSRGPV TLVGDAGYCASPLSGMGTSLALVGAYVLAGELGPADMFAHAKLGLALSRYESTMRPYIERCQDLPTGIDG YLPKSALDITIYTQVMKWMQRWPIRSYAARKWFTTADAIQLPSYPAAQNKR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3039 | - | - | 100% (402) | monooxygenase |
| M. smegmatis MC2 155 | MSMEG_3318 | - | 2e-54 | 37.78% (352) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_5719 | - | 1e-47 | 36.21% (406) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0590c | - | 9e-45 | 35.98% (353) | hypothetical protein Mb0590c |
| M. gilvum PYR-GCK | Mflv_2621 | - | 6e-10 | 26.15% (348) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv1260 | - | 9e-64 | 41.86% (344) | hypothetical protein Rv1260 |
| M. leprae Br4923 | MLBr_02276 | - | 6e-07 | 24.88% (426) | putative FAD-linked oxidoreductase |
| M. abscessus ATCC 19977 | MAB_0649c | - | 4e-66 | 37.22% (395) | putative monooxygenase |
| M. marinum M | MMAR_2185 | - | 1e-152 | 67.25% (403) | oxidoreductase |
| M. avium 104 | MAV_1408 | - | 2e-63 | 41.91% (346) | hypothetical protein MAV_1408 |
| M. thermoresistible (build 8) | TH_0968 | - | 1e-05 | 29.07% (172) | 3-(3-hydroxy-phenyl)propionate hydroxylase |
| M. ulcerans Agy99 | MUL_1770 | - | 1e-152 | 67.25% (403) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_3960 | - | 3e-14 | 28.53% (319) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2621|M.gilvum_PYR-GCK ----MSARISVIGAGISGLAAAVALERAGHHVSVIEQRTDTGAG-SGISL
Mvan_3960|M.vanbaalenii_PYR-1 ----MPAHTIVIGAGIAGLATAVALRRVGHDVTVIEQRTDLTSG-AGISI
MMAR_2185|M.marinum_M ---MAKPIVLISGAGIAGPALAFWLTHSGYQVVVTELADDIRPGGQTVDL
MUL_1770|M.ulcerans_Agy99 ---MAKPIVLISGAGIAGPALAFWLTHSGYQVVVTELADDIRPGGQTVDL
MSMEG_3039|M.smegmatis_MC2_155 ---MGQPTVLISGAGVAGTSLAHWLTEYGYRAVVVETAPTLRLGGQTVDL
MAB_0649c|M.abscessus_ATCC_199 ---MSR-EILISGGGIAGPALAYWLVQEGHSVTIVERAATVRNGGQAVDF
Rv1260|M.tuberculosis_H37Rv -----MKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLRPGGQAIDV
MAV_1408|M.avium_104 -----MSDVLVSGASVAGTAAAFWLGRHGHSVTVVERHRGPRPGGQAIDV
Mb0590c|M.bovis_AF2122/97 ------MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYMIDF
TH_0968|M.thermoresistible__bu --MTERVDVVIVGAGPSGLTLANILGLQGVRTLVVEERDTLIDYPRGVGL
MLBr_02276|M.leprae_Br4923 MRVETSADVVVVGAGPAGSAAATWAARAGNDVIVIDSVCFPRDKACGDGL
: *.. :* : * * : : ..
Mflv_2621|M.gilvum_PYR-GCK WPNALAALDQIGLGDSVRDAGGRVTAGAIRWRDGTWVRRPSVR----RIV
Mvan_3960|M.vanbaalenii_PYR-1 WPNALAALDQIGLGDNVRQAGGRVTAGAIRWRDGTWLRRPSAQ----RIV
MMAR_2185|M.marinum_M RGAGRLVIERMGLLEQMRQRSLRQRGIAWIRADGRRRAEMPVE----AFH
MUL_1770|M.ulcerans_Agy99 RGAGRLVIERMGLLEQMRQRSLRQRGIAWIRADGRRRAEMPVE----AFH
MSMEG_3039|M.smegmatis_MC2_155 RGAGRDVVTRMGLLDEMRARSLDQRGIAWVRGNGRRRAEMPVD----AFD
MAB_0649c|M.abscessus_ATCC_199 RGPSIDVLDKMGVLDAVRAQATHMGSLVMVDADGKEIARFPSE----VIS
Rv1260|M.tuberculosis_H37Rv RGPALDVLERMGLLAAAQEHKTRIRGASFVDRDGNELFRDTES---TPTG
MAV_1408|M.avium_104 RGPALGVLERMGLLAAAAKRRTQIRGSSVVDRDGNELSRDTEAAISGPTG
Mb0590c|M.bovis_AF2122/97 WGVGYQVAKRMGITDQIAAAGYHMEHVRSVGPTGKVKADLGVD----VFR
TH_0968|M.thermoresistible__bu DDEALRTFQSIGLVDRILPHTVPNQILRFFDAKRRLLAEMAPPDARFGWP
MLBr_02276|M.leprae_Br4923 TPRAVAELKRLGLDDWLNTR-IRHRGLRMSGFGGEVEVDWPGP----SFP
. :*:
Mflv_2621|M.gilvum_PYR-GCK DALGEPLVVVRRSRLTDIL-REALPAG-TVRTGLAATRVSVGASSVRITL
Mvan_3960|M.vanbaalenii_PYR-1 HALGEPLVVVRRSALTEIL-LDALPPD-TVQTGLSATALSIAAATARVTL
MMAR_2185|M.marinum_M GNGPVSELEILRGDLAAVL-YRATAAGTDYRFGTRITDLAPSGDAVQARL
MUL_1770|M.ulcerans_Agy99 GNGPVSELEILRGDLAAVL-YRATAAGTDYRFGTRITDLAPSGDAVQARL
MSMEG_3039|M.smegmatis_MC2_155 GNGMVSALEILRGDLVEVL-YNATSARAEYRFGTRITEIDSSG----ATL
MAB_0649c|M.abscessus_ATCC_199 G-----ELEILWGDLARIL-HEAVREHVVFRFADSITGVRDDGAKVTVSF
Rv1260|M.tuberculosis_H37Rv GPVNSPDIELLRDDLVELL-YGATQPSVEYLFDDSISTLQDDGDSVRVTF
MAV_1408|M.avium_104 GPIEGPDIELLRDDLVELL-YGASQWTAEYLFDDTITALDDRGAAVRVSF
Mb0590c|M.bovis_AF2122/97 RMVGDDFTSLPRGDLAAAI-YTTIEDQVETIFDDSIATIDEHRDGVRLTF
TH_0968|M.thermoresistible__bu KRNGFVQPMVDAELYAGLDRFDHVEVRFGHRMQNCVEASDAGEDGVTVEF
MLBr_02276|M.leprae_Br4923 STSSAVPRLELDDRIRKVA--ENSGARMLLGTKAVSVYHDSSRRAASVTL
:
Mflv_2621|M.gilvum_PYR-GCK SDGE-VRESDAVVGADGVNSVLARTLNGP---LRTRYVGYTAWRGIAAHP
Mvan_3960|M.vanbaalenii_PYR-1 SDGR-TREADAVVGADGVNSMVARALNGP---LPSRYVGYTAWRGVAAYR
MMAR_2185|M.marinum_M SDGT-TVRADLVVGADGPHSGVRRLAFGPEEQFARPLGGYNAWFSAPDTV
MUL_1770|M.ulcerans_Agy99 SDGT-TVRADLVVGADGPHSGVRRLAFGPEEQFARPLGGYNAWFSAPDTV
MSMEG_3039|M.smegmatis_MC2_155 SDGT-RVDADLIVGADGPHSSVRRMVFGPEEQYVTLLGGYNAWFTAPDTA
MAB_0649c|M.abscessus_ATCC_199 SRSA-PESYDLLIGADGVHSGVRALTFGPEHEFVTQLGQYFTFFAMDNHL
Rv1260|M.tuberculosis_H37Rv ERAA-AREFDLVIGADGLHSNVRRLVFGPEEQFVKRLGTHAAIFTVPNFL
MAV_1408|M.avium_104 ERAA-PRDFDLVIGADGLHSNVRRLVFGPEDEFIERLGTHAAIFTVPNFL
Mb0590c|M.bovis_AF2122/97 ERTA-PRDFDLVIGADGLHSNVRRLVFGPERDFEHYLGCKVAACVVDGYR
TH_0968|M.thermoresistible__bu ADGHPPVRASYVVGCDGGRSTTRRLMGVSFDGTTSSTRWLVVDVANDPLG
MLBr_02276|M.leprae_Br4923 ADGT-EVGCRQLIIADGARSPLGRKLGRSWHQKTVYGVAARGYLTTPRSD
:: .** .* .
Mflv_2621|M.gilvum_PYR-GCK -LDP----ELGGETLGPGTQVGHVPLGPDHTYWFATERTAEGGSAPGGEH
Mvan_3960|M.vanbaalenii_PYR-1 -LDP----ALAGETMSAGTEVGHVPLGPDHTYWFATERTREGSRSAGGEH
MMAR_2185|M.marinum_M GLNGWYLMYQAPGGLNASMRPSHDPATAKAGLAFRSAPIRYDRGDLDAQR
MUL_1770|M.ulcerans_Agy99 GLNGWYLMYQAPGGLNASMRPSHDPATAKAGLAFRSAPIRYDRGDLDAQR
MSMEG_3039|M.smegmatis_MC2_155 GLDGWYLMYQVPG-LNASMRPSHDPALCKAGLAFRSGPVDYDRRDPATQL
MAB_0649c|M.abscessus_ATCC_199 GLDHQTVGFREGT-RGVGIQATAPDAPARGSLSFSDDHLEFDYRDVEGNK
Rv1260|M.tuberculosis_H37Rv ELDYWQTWHYGDS-TMAGVYSARNNTEARAALAFMDTELRIDYRDTEAQF
MAV_1408|M.avium_104 GLDYWQMWHYGDS-TMAGVYSARDNAEARAMLGFMDAELRLDYRDTEAQF
Mb0590c|M.bovis_AF2122/97 PRDERSYVLYNTVDRQLARFALRG----DRTMFLFVFRAEHDNPGVAPK-
TH_0968|M.thermoresistible__bu ---------HPNSEVGADPARPYVSISIAHGIRRFEFMIHPHETDAEVDD
MLBr_02276|M.leprae_Br4923 DLWLTSHLELRSPDGAVLPGYGWIFPLGNGEVNIGVGALSTSKRPADLAL
Mflv_2621|M.gilvum_PYR-GCK AYLTAKVADWADPIPRLVATTDPGDLLRNDLYDRARAARWSDGRAVLIGD
Mvan_3960|M.vanbaalenii_PYR-1 AYLTAKLAGWADPIPALLASTDPADVLRNDLYDRAQPRDWSRGPAVIVGD
MMAR_2185|M.marinum_M DLLAARFAGAGWQSDALIAAAREADDFYLDAIVQIHLDAWSRGRVTLVGD
MUL_1770|M.ulcerans_Agy99 DLLAACFAGAGWQSDALIAAAREADDFYLDAIVQIHLDAWSRGRVTLVGD
MSMEG_3039|M.smegmatis_MC2_155 ALLNTHFAGAGWHCADLLAAAAVADDFYFDAFLQVHMPTLSRGPVTLVGD
MAB_0649c|M.abscessus_ATCC_199 KLFSERFTGFGWETPAVLRALSVTAEPYFDSLCQVHLDTYSRGRVCLLGD
Rv1260|M.tuberculosis_H37Rv AELQRRMAEDGWVRAQLLHYMRSAPDFYFDEMSQILMDRWSRGRVALVGD
MAV_1408|M.avium_104 AELERRMAGEGWVRPQLLEYMRTAPDFYFDEMSQIKMDRWSRGRVALVGD
Mb0590c|M.bovis_AF2122/97 DELRDQFGDVGWESRDILAALDDVEDLYFDVVSQIRMDRWSRGRVLLIGD
TH_0968|M.thermoresistible__bu PAFVRRMLGRRIPYPERVDMIR----YRVYTHHSRIAGSFRKGRLLLAGD
MLBr_02276|M.leprae_Br4923 RSLISYYTDLRRHEWGFSGQPRAVSSALLPMGGAVSG--VAGPNWMLIGD
: : **
Mflv_2621|M.gilvum_PYR-GCK AAHPMRPHLGQGGCQGIEDAAILARFLELAD-----------------DV
Mvan_3960|M.vanbaalenii_PYR-1 AAHPMRPHLGQGGCQGLEDAAILARFVGLSP-----------------DL
MMAR_2185|M.marinum_M AGYCASPLSGMGTSLALVGAYVLAGELGPAHG----------DGIDEAAL
MUL_1770|M.ulcerans_Agy99 AGYCASPLSGMGTSLALVGAYVLAGELGPAHG----------DGIDEAAL
MSMEG_3039|M.smegmatis_MC2_155 AGYCASPLSGMGTSLALVGAYVLAGELGPA------------DMFAHAKL
MAB_0649c|M.abscessus_ATCC_199 AAWCASPRSGMGTSLAIVGAYVLAHELRSA----------------QGDF
Rv1260|M.tuberculosis_H37Rv AGYCCSPLSGQGTSVALLGAYILAGELKAAG----------------DDY
MAV_1408|M.avium_104 AGYCCSPLSGQGTSVALLGAYILAGELKAAG----------------EDH
Mb0590c|M.bovis_AF2122/97 AAGCISLLGGEGTGLAITEAYVLAGELARAG----------------GDH
TH_0968|M.thermoresistible__bu AAHLMPVWQGQGYNSGIRDAANLGWKLAAVVNGHAHDALLDTYDLERREH
MLBr_02276|M.leprae_Br4923 AAACVNPLNGEGIDYGLETGRLAAELLDLRDLS----------YVWPSLL
*. * * .: . . :
Mflv_2621|M.gilvum_PYR-GCK PTAFER-FEAFRKPRVGMLVREAQTLGRIVNVRPAVLSG--LAGRATALI
Mvan_3960|M.vanbaalenii_PYR-1 PAAFDR-FGAFRRRRVRPLVRESAAIGRIVNLRPAFLSG--VASRASALI
MMAR_2185|M.marinum_M AAALAR-YETVLRPYVANCQDLPNSIDRFLPMSESEIRSNAAAMKYMQRW
MUL_1770|M.ulcerans_Agy99 AAALAR-YETVLRPYVANCQDLPNSIDRFLPMSESEIRSNAAAMKYMQRW
MSMEG_3039|M.smegmatis_MC2_155 GLALSR-YESTMRPYIERCQDLPTGIDGYLPKSALDITIYTQVMKWMQRW
MAB_0649c|M.abscessus_ATCC_199 SIAFAR-FHTLMAPYAARCQRLALDALKIGEADSPWATGLRRLGLWSLRL
Rv1260|M.tuberculosis_H37Rv QLGFAN-YHAEFHGFVERNQWLVSDN---IPGGAP--------------I
MAV_1408|M.avium_104 EAGFAN-YHREFADYVQRNQWLVVDN---IPGGAP--------------I
Mb0590c|M.bovis_AF2122/97 RRAFDA-YEKRLRPFIEGKQASAAKFIWFFRHPNP-----------IRPV
TH_0968|M.thermoresistible__bu ARAMID-LSTMVGRVISPTNRRVAALRDRLIHAASVVPTLKRYVLEMRFK
MLBr_02276|M.leprae_Br4923 QQHYGRGFSVARRLALLLTFKRCLPAIGPSAMRSTSLITIAVRVMANLVT
Mflv_2621|M.gilvum_PYR-GCK PERMVTAHLAWIAAGSAFVLPTAADLAR----------------------
Mvan_3960|M.vanbaalenii_PYR-1 PEWAVASHLASIAAGSAFILPTAGDVGG----------------------
MMAR_2185|M.marinum_M P-FRFFAERKWFTIAESIELPRYPRLP-----------------------
MUL_1770|M.ulcerans_Agy99 P-FRFFAERKWFTIAESIELPRYPRLP-----------------------
MSMEG_3039|M.smegmatis_MC2_155 P-IRSYAARKWFTTADAIQLPSYPAAQNKR--------------------
MAB_0649c|M.abscessus_ATCC_199 PGIRQLVARQALKVGRSFALPAYD--------------------------
Rv1260|M.tuberculosis_H37Rv P------QEEFERIVHSITIKDY---------------------------
MAV_1408|M.avium_104 P------QEVFERIVASITLKDY---------------------------
Mb0590c|M.bovis_AF2122/97 VSQRCDAHDELRPAGDAVRRQRA---------------------------
TH_0968|M.thermoresistible__bu PMPRYLQGAVYHGGPRSKSSPTGTLFIQPRVDTRDAENVLLDDVLGPGFA
MLBr_02276|M.leprae_Br4923 DDDADWVARVWRSGGWASWLVDRRPPFS----------------------
:
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3960|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_2185|M.marinum_M --------------------------------------------------
MUL_1770|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_3039|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0649c|M.abscessus_ATCC_199 --------------------------------------------------
Rv1260|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1408|M.avium_104 --------------------------------------------------
Mb0590c|M.bovis_AF2122/97 --------------------------------------------------
TH_0968|M.thermoresistible__bu VLCWSNNLRAVLGEDAFSHWKSLGATFVEARPITQLHWPGHDDPDVVVVG
MLBr_02276|M.leprae_Br4923 --------------------------------------------------
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3960|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_2185|M.marinum_M --------------------------------------------------
MUL_1770|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_3039|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0649c|M.abscessus_ATCC_199 --------------------------------------------------
Rv1260|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1408|M.avium_104 --------------------------------------------------
Mb0590c|M.bovis_AF2122/97 --------------------------------------------------
TH_0968|M.thermoresistible__bu DRTGALKGWFDVHTDSVLFLRPDRCIAAACIAQRAPETSAALSEVMCLTQ
MLBr_02276|M.leprae_Br4923 --------------------------------------------------
Mflv_2621|M.gilvum_PYR-GCK ----------------------------
Mvan_3960|M.vanbaalenii_PYR-1 ----------------------------
MMAR_2185|M.marinum_M ----------------------------
MUL_1770|M.ulcerans_Agy99 ----------------------------
MSMEG_3039|M.smegmatis_MC2_155 ----------------------------
MAB_0649c|M.abscessus_ATCC_199 ----------------------------
Rv1260|M.tuberculosis_H37Rv ----------------------------
MAV_1408|M.avium_104 ----------------------------
Mb0590c|M.bovis_AF2122/97 ----------------------------
TH_0968|M.thermoresistible__bu GGGNGAASPVLHVAQSAAEPSGTATRST
MLBr_02276|M.leprae_Br4923 ----------------------------